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Braz. dent. j ; 32(4): 83-95, July-Aug. 2021. tab, graf
Article in English | LILACS, BBO | ID: biblio-1345517


Abstract This study evaluated the bone repair in surgical defects of rats treated with hyaluronic acid (HA) associated or not with Hevea brasiliensis fraction protein (F-1). Bone defect were created in 15 albino Wistar rats divided into 3 groups (n=5): Control group (1) - blood clot; HA group (2) - 0.5% hyaluronic acid; HAF1 group (3) - 0.1% F-1 protein fraction dissolved in 0.5% hyaluronic acid. After 4 weeks, the animals were euthanized and the bone repair was evaluated through histomorphometric analysis, zymography and immunohistochemistry. The neoformed bone area did not show a significant difference (p = 0.757), but there was a tendency for bone trabeculation to increase in the groups HA and HAF1. For immunohistochemically analysis, there was a difference in vascular endothelial growth factor (VEGF) labeling (p = 0.023), being higher in the groups HA and HAF1 than the control group. No significant difference in bone sialoprotein (BSP) (p = 0.681), osteocalcin (p = 0.954), however, significant difference in platelet endothelial cell adhesion molecule-1 (CD-31) (p = 0.040), with HAF1 group being significantly lower than the control. For zymographic analysis, there was no significant difference for metalloproteinase-2 (MMP-2) (p = 0.068), but there was a tendency to increase MMP-2 in the HA group. Despite the influence on angiogenic factors and the apparent tendency for greater trabeculation in the HA and HAF1 groups, there was no significant difference in the area of ​​newly formed bone tissue in the analyzed period.

Resumo Este estudo avaliou o reparo ósseo em defeitos cirúrgicos de ratos tratados com ácido hialurônico (AH) associado ou não à fração proteica de Hevea brasiliensis (F-1). Foram criados defeitos ósseos em 15 ratos albinos Wistar divididos em 3 grupos (n = 5): Grupo controle (1) - coágulo sanguíneo; Grupo HA (2) - ácido hialurônico 0,5%; Grupo HAF1 (3) - fração proteica F-1 0,1% dissolvida em ácido hialurônico a 0,5%. Após 4 semanas, os animais foram submetidos à eutanásia e o reparo ósseo avaliado por meio de análise histomorfométrica, zimografia e imunohistoquímica. A área óssea neoformada não apresentou diferença significativa (p = 0,757), mas houve tendência de aumento da trabeculação óssea nos grupos HA e HAF1. Para a análise imunoistoquímica, houve diferença na marcação do fator de crescimento endotelial vascular (VEGF) (p = 0,023), sendo maior nos grupos HA e HAF1 do que no grupo controle. Nenhuma diferença significativa na sialoproteína óssea (BSP) (p = 0,681), osteocalcina (p = 0,954), no entanto, diferenças significativas foram encontradas para a molécula de adesão de células endoteliais plaquetárias-1 (CD-31) (p = 0,040), com o grupo HAF1 sendo significativamente inferior ao controle. Para a análise zimográfica, não houve diferença significativa para metaloproteinase-2 (MMP-2) (p = 0,068), mas houve tendência de aumento da MMP-2 no grupo HA. Apesar da influência sobre os fatores angiogênicos e da aparente tendência de maior trabeculação nos grupos HA e HAF1, não houve diferença significativa na área de tecido ósseo neoformado no período analisado.

Animals , Rats , Hyaluronic Acid , Latex , Bone Regeneration , Matrix Metalloproteinase 2 , Vascular Endothelial Growth Factor A
Int. braz. j. urol ; 47(2): 322-332, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1154465


ABSTRACT Purpose: We assessed the efficacy and safety of a single injection of three bulking agents over the short- and long-term follow-ups in rabbits. Dermal and preputial matrices were compared with Deflux (DxHA) injection. Material and methods: Twenty-four rabbits were divided into three groups. Group I (n=8) underwent the injection of a lyophilized dermal matrix (LDM) beneath the seromuscular layer of the bladder wall. Rabbits in group II (n=8) were injected with lyophilized preputial matrix (LPM). Rabbits of group III (n=8) were injected with DxHA as the control group. They were followed up for 1 and 6 months after the injection. Subcutaneous injection of all bulking agents was also performed in nude mice. Biopsies were stained with LCA (leukocyte common antibody), CD68, CD31, and CD34. Scanning electron microscopy (SEM) and MTT assay were also performed. Results: Immunohistochemistry staining with CD68 and LCA revealed higher inflammation grade in LDM as compared with LPM and DxHA. Fibrosis grade was also higher in LDM both in short- and long-term follow-ups. However, no significant difference was detected in CD31 and CD34 staining between control and experimental groups. SEM analysis showed that the particle size of LPM was more similar to DxHA. MTT assay revealed that cell proliferation was similar in DxHA, LDM, and LPM. In-vivo assay in nude mice model showed more promising results in LPM as compared with LDM. Conclusion: The long-term results demonstrated that LPM was more similar to Deflux with the least local tissue reaction, inflammation, and fibrosis grade.

Animals , Dextrans , Hyaluronic Acid , Rabbits , Urinary Bladder , Injections , Mice , Mice, Nude
Clinics ; 76: e1987, 2021. tab
Article in English | LILACS | ID: biblio-1249589


OBJECTIVES: This study aims to compare the clinical efficacy of an integrated approach to prevent and treat the recurrence of moderate-to-severe intrauterine adhesions (IUA) after hysteroscopic transcervical resection of adhesion (TCRA). METHODS: The study included a total of 70 patients with moderate-to-severe IUAs who underwent TCRA. Patients were randomly divided into two groups: treatment group (n=35) and control group n=35). In the treatment group, patients underwent balloon uterine stent placement and artificial cycle as well as received intrauterine perfusion of Danshen injection and oral Chinese medicine. In the control group, patients underwent balloon uterine stent placement and artificial cycle as well as received hyaluronic acid sodium and intrauterine device (IUD). Follow-up was performed after treatment of uterine cavity, menstruation and pregnancy. RESULTS: After 3 months of treatment, we observed a significantly lower rate of intrauterine re-adhesion (45.71% versus 77.14%, p=0.044) and significantly higher clinical efficiency (82.86% versus 77.14%, p=0.025) in the treatment group than those in the control group. After 6 months of treatment, we observed a significantly higher clinical efficiency in the treatment group than that in the control group (88.57% versus 68.57%, p=0.039). During the follow-up period, the pregnancy rate was 45.71% and 37.14% in the treatment group and control group, respectively, although the difference was not statistically significant (p=0.628). CONCLUSIONS: After surgical management of IUA, the integrated treatment combining a uterus stent placement and artificial cycle with Danshen injection and oral Chinese medicine can improve the condition of menstruation, and prevent and treat recurrence of IUA.

Humans , Female , Pregnancy , Uterine Diseases/surgery , Uterine Diseases/prevention & control , Intrauterine Devices , Hysteroscopy , Tissue Adhesions/prevention & control , Hyaluronic Acid/therapeutic use
Frontiers of Medicine ; (4): 292-301, 2021.
Article in English | WPRIM | ID: wpr-880958


The high- and the low-molecular weight hyaluronic acids (HMW-HA and LMW-HA, respectively) showed different biological activities in inflammation. However, the role of LMW-HA in inflammatory response is controversial. In this study, we aimed to investigate the effect of bioactive hyaluronan (B-HA) on lipopolysaccharide (LPS)-induced inflammatory responses in human macrophages and mice. B-HA was produced from HA treated with glycosylated recombinant human hyaluronidase PH20. Human THP-1 cells were induced to differentiate into macrophages. THP-1-derived macrophages were treated with B-HA, LPS, or B-HA + LPS. The mRNA expression and the production of inflammatory cytokines were determined using quantitative real-time PCR and enzyme-linked immunosorbent assay. The phosphorylation levels of proteins in the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and IRF-3 signaling pathways were measured using Western blot. The in vivo efficacy of B-HA was assessed in a mouse model of LPS-induced inflammation. Results showed that B-HA inhibited the expression of TNF-α, IL-6, IL-1, and IFN-β, and enhanced the expression of the antiinflammatory cytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and in vivo. B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65, IKKα/β, IκBα, JNK1/2, ERK1/2, p38, and IRF-3. In conclusion, our results demonstrated that the B-HA attenuated the LPS-stimulated inflammatory response by inhibiting the activation of the TLR4 signaling pathway. B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease.

Animals , Cytokines , Hyaluronic Acid , Lipopolysaccharides , Mice , NF-kappa B/metabolism , Signal Transduction , Toll-Like Receptor 4
Article in Chinese | WPRIM | ID: wpr-879456


OBJECTIVE@#To compare clinical effects of compound betamethasone and compound betamethasone with hyaluronic acid in treating moderate-severe knee osteoarthritis (KOA).@*METHODS@#A prospective randomized controlled study was conducted in 116 patients with unilateral moderate-severe KOA patients from February 2017 to November 2017 and divided into observation group and control group, 58 patients in each group. In observation group, there were 15 males and 43 females aged from 45 to 80 years old with an average of (66.45±6.31) years old;according to Kellgren-Lawrence(K-L) classification, 42 patients were type Ⅲ and 16 patients were type Ⅳ;the courses of disease ranged from 4 to 8 years with an average of (5.25±2.21) years;the patients were treated by injecting 1 ml compound betamethasone into knee joint. In control group, there were 13 males and 45 females aged from 45 to 80 years old with an average of (64.89±6.41) years old;according to K-L classification, 43 patients were type Ⅲ and 15 patients were type Ⅳ;the courses of disease ranged from 4 to 10 years with an average of (5.41±2.35) years;the patients were treated by knee joint injection of 4 ml hyaluronic acid and 1 ml compound betamethasone. Visual analog scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC) were used to evaluate clinical effects before treatment and 1 week, 1, month, 3 and 6 months after treatment.@*RESULTS@#Totally 55 patients in observation group were followed up for 6 months, and 3 patients were quit at 3 months after treatment for poor efficacy. Totally 56 patients in control group were followed up for 6 months, and 2 patients were withdrew from the follow-up on the first and third month respectively for poor efficacy. There were no statistical difference in VAS and WOMAC between two groups before treatment and different time points after treatment (@*CONCLUSION@#For patients with moderate-severe KOA, there is no significant difference in therapeutic effect between compound betamethasone injection and compound betamethasone combined with hyaluronic acid injection, and long-term effect of two methods is not good.

Betamethasone , Child , Child, Preschool , Female , Humans , Hyaluronic Acid , Injections, Intra-Articular , Male , Osteoarthritis, Knee/drug therapy , Prospective Studies , Treatment Outcome
Rev. argent. reumatolg. (En línea) ; 31(4): 40-43, dic. 2020. ilus, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1288210


El síndrome autoinmune/inflamatorio inducido por adyuvantes (ASIA) es una condición en la cual la exposición a un adyuvante lleva a una respuesta inmune aberrante dando como resultado signos y síntomas de enfermedades autoinmunes. Se presenta el caso de una paciente con artritis y púrpura palpable luego de inyección labial de ácido hialurónico.

Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) is a condition in which exposure to an adjuvant leads to an aberrant immune response resulting in signs and symptoms of autoimmune diseases. We present the case of a patient with arthritis and palpable purpura after hyaluronic acid lip injection.

Vasculitis , Autoimmune Diseases , Adjuvants, Pharmaceutic , Hyaluronic Acid
Rev. colomb. reumatol ; 27(3): 215-217, jul.-set. 2020. tab
Article in Spanish | LILACS | ID: biblio-1251661


RESUMEN Se presenta un caso de artritis séptica de rodilla por Pseudomonas stutzeri, bacilo gramnegativo aerobio ampliamente distribuido en la naturaleza y que rara vez ocasiona infecciones graves en el ser humano. Se trata de una mujer de 84 arios, hemodializada, que desarrolla una artritis séptica de rodilla derecha tras una inflitración con ácido hialurónico y que evoluciona favorablemente tras terapia antibiótica. Se debe tener en cuenta esta etiología cuando hay antecedentes de invasión local de la articulación y en estados de inmunosupresión tal y como sucede en nuestra paciente.

A B S T R A C T A case is presented of septic knee arthritis caused by Pseudomonas stutzeri, which is an aerobic gram-negative bacillus widely distributed in nature and rarely causes serious infections in humans. The patient is an 84-year-old woman on haemodialysis, who developed a septic arthritis of the right knee after a hyaluronic acid injection. There was a favourable outcome after antibiotic therapy. This aetiology should be taken into account when there is a history of local invasion of the joint and in states of immunosuppression, as occurred in this patient.

Humans , Female , Aged, 80 and over , Arthritis, Infectious , Pseudomonas stutzeri , Therapeutics , Causality , Hyaluronic Acid , Joints , Knee
An. Fac. Cienc. Méd. (Asunción) ; 53(2): 153-156, 20200800.
Article in Spanish | LILACS | ID: biblio-1119711


El manejo de heridas complejas con compromiso de la dermis en la mano es un desafío para los cirujanos; el uso de sustitutos dérmicos en la actualidad se presenta como una posibilidad de obtener una cicatriz estética y funcionalmente adecuada. Presentamos un caso manejado en nuestro centro con excelentes resultados funcionales y estéticos.

The management of complex wounds with involvement of the dermis in the hand is a challenge for surgeons; The use of dermal substitutes at present is presented as a possibility of obtaining an aesthetically and functionally adequate scar. We present a case handled in our center with excellent functional and aesthetic results.

Hand/anatomy & histology , Hyaluronic Acid
s.l; RedARETS; feb. 2020.
Non-conventional in Spanish | LILACS, BRISA | ID: biblio-1095215


TECNOLOGÍA EVALUADA: Inyección peritendinosa de ácido hialurônico. GUIAS DE PRÁCTICA CLÍNICA: No se encontraron guias de práctica clínica que evalúen la recomendación incluida en la pregunta de investigación. BUSQUEDA BIBLIOGRÁFICA: Terminología: Medical Subject Headings (MeSH). Estrategia en Medline. Estrategia epistemonikos. Estrategia Cochrane library. RESULTADOS: Desenlace: Reducción del dolor 3 a 6 semanas. Desenlace: mejoría funcional a las 6 semanas. I2 mayor al 90%. Diferencias en intervenciones y pacientes. Evaluado para lesiones tendinosas sin ruptura en general del manguito de los rotadores. Ausencia de estudios pequeños con resultados negativos. Estudios registrados en clinical trials. gov no publicados.

Humans , Tendinopathy/drug therapy , Hyaluronic Acid/therapeutic use , Technology Assessment, Biomedical , Cost-Benefit Analysis
Rev. cuba. reumatol ; 22(supl.1): e857,
Article in Spanish | LILACS, CUMED | ID: biblio-1280388


La osteoartritis se considera una de las principales causas de discapacidad funcional. Es una enfermedad crónica y degenerativa que presenta un pico de incidencia en personas mayores de 60 años. El propósito de este trabajo es mostrar los avances en la terapia de pacientes con osteoartritis basada en ácido hialurónico para pacientes con osteoartritis. El ácido hialurónico posee funciones en la articulación que abarcan la lubricación, servir como relleno de espacio para permitir que la articulación permanezca abierta y la regulación de actividades celulares como la unión de proteínas. Cada vez hay más pruebas de que, dentro del espectro de derivados disponibles del ácido hialurónico, la eficacia de los productos de ácido hialurónico con un alto peso molecular es superior a la eficacia de los derivados con un bajo peso molecular. Aprovechando el control espacial de ciertos tipos de hidrogeles de ácido hialurónico, se están desarrollando sistemas de microdispositivos que pueden encapsular células madre embrionarias viables y luego recuperarlas mediante interrupción mecánica. Estas células madre podrían usarse para el tratamiento de enfermedades como la osteoartritis. El ácido hialurónico es un fármaco que puede para ayudar a reducir los efectos secundarios de la osteoartritis(AU)

Osteoarthritis is considered one of the main causes of functional disability. Osteoarthritis conceptualized as a chronic and degenerative disease that presents a peak incidence in people older than 60 years. To show advances in hyaluronic acid-based therapy for patients with osteoarthritis. Hyaluronic acid has functions in the joint that include lubrication, which serves as a filling of space to allow the joint to remain open and the regulation of cellular activities such as protein binding. Hyaluronic acid is a potential drug to help reduce the side effects of osteoarthritis(AU)

Humans , Middle Aged , Aged , Osteoarthritis/therapy , Hyaluronic Acid/therapeutic use
Adv Rheumatol ; 60: 26, 2020. tab, graf
Article in English | LILACS | ID: biblio-1130806


Abstract Background: Injection of Hylan G-F20 (HY) into joints may provoke local flares, which mechanisms may involve reaction to protein contaminants. We have previously developed a protein-free saline-soluble galactomannan derived from guar gum (GM) that displays both analgesia and chondroprotection in experimental osteoarthritis (OA). We now demonstrate that both GM and Hylan G-F20 (HY) promote mild synovitis with cytokine release after intra-articular injection. Methods: Mice received 100 μg/25 μL GM or HY or saline into the knees. Joint pain was evaluated using von Frey test; cell influx, interleukin (IL)-1, IL-6, and CXCL-1 (pg/mL) levels were assessed in joint lavage at 6 h. Synovia were excised for histopathology. Results: Neither GM nor HY after being given into mice knee joints induced pain albeit promoting mild cell influx into joint washings as well as mild synovitis at histology, with no damage to the underlying cartilage. HY but not GM promoted IL-1 release into mice joints. Both compounds induced IL-6 and CXCL-1 release. Conclusion: Intra-articular injection of HY or GM promote acute transient synovitis whilst not provoking detectable significant joint damage. Local administration of these polysaccharides induces acute intra-articular release of inflammatory cytokines, which may account for joint flares following viscosupplementation.(AU)

Animals , Mice , Osteoarthritis/physiopathology , Polysaccharides/administration & dosage , Viscosupplementation/instrumentation , Hyaluronic Acid/administration & dosage
Braz. arch. biol. technol ; 63: e20190386, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132204


Abstract The aims of this work were to produce hyaluronic acid (HA) by Streptococcus zooepidemicus ATCC 39920 in a low cost sugarcane molasses fermentation medium and to employ the produced HA to obtain films blends based on polyvinyl alcohol (PVA). The films were produced using solution casting method and they were characterized according to their microstructure, mechanical and barrier properties. HA was added in different concentrations (0, 5, 10 and 15% (w/w)), and glycerol was used as a plasticizer (25 g/100 g solids). All formulations resulted in easily manipulated films with good appearance. The addition of HA on PVA films increased their thermal stability, solubility, swelling index, water vapor permeability and elongation. Microbial HA sample combined with PVA showed to be a promising material to biomedical application, and an addition between 5 and 10% (w/w) was sufficient to improve PVA films properties.

Animals , Polyvinyl Alcohol , Molasses , Streptococcus equi/metabolism , Hyaluronic Acid/biosynthesis , Plasticizers , Biotechnology
Braz. j. med. biol. res ; 53(8): e9886, 2020. tab
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1132547


The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Therapy efficacy was evaluated based on the ulcer size and pain score before versus 7 days after either therapy. The paired t-test, chi-squared test, and independent t-test were utilized for statistical analyses. There was no significant difference in ulcer size or pain score between the HA and dexamethasone groups, on day 1 or day 7. Both treatments were tolerated well and no side effects were reported. No significant differences in body temperature, respiration rate, pulse, or systolic/diastolic blood pressure were observed between the start (day 1) and end of treatment (day 7), for either treatment. HA and dexamethasone showed similar efficacy in reducing ulcer size and pain scores, and were tolerated equally well in children with RAU. Future high-quality studies with larger numbers of patients are needed to confirm our findings.

Humans , Male , Female , Child , Stomatitis, Aphthous/drug therapy , Dexamethasone/therapeutic use , Adjuvants, Immunologic/therapeutic use , Hyaluronic Acid/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Pain , Recurrence , Retrospective Studies
Rev. clín. periodoncia implantol. rehabil. oral (Impr.) ; 12(3): 151-153, Dec. 2019. tab, ilus
Article in Spanish | LILACS | ID: biblio-1058331


RESUMEN: El objetivo de este trabajo es evaluar el efecto de remodelación y relleno mediante aplicación de ácido hialurónico en papilas gingivales de sector estético con defectos de triángulo negro en un paciente tratado periodontalmente. Se inyectaron 0.15 ml de gel de ácido hialurónico dividido en 3 sesiones. Clínicamente se observó aumento de volumen y aumento de dimensiones verticales y horizontales en las papilas, mejorando así los parámetros estéticos. Como conclusión la aplicación de ácido hialurónico es efectiva en la remodelación y relleno en pérdidas de papila clase I de Nordland y Tarnow.

ABSTRACT: The objective of this work is to evaluate the effect of remodeling and filling through the application of hyaluronic acid in gingival papilla in the aesthetic sector with black triangle defects, in a periodontally- treated patient. In 3 portioned sessions, 0.15 ml of hyaluronic acid gel was injected. Clinically, an increase in volume was observed, and vertical and horizontal dimensions in the papilla increased too, thus improving aesthetic parameters. In conclusion, the application of hyaluronic acid is effective in the remodeling and filling in losses of class I papilla (Nordland and Tarnow classification).

Humans , Female , Adult , Dental Papilla , Esthetics, Dental , Gingiva , Hyaluronic Acid
Article in English | LILACS | ID: biblio-1058333


ABSTRACT: Background: Hyaluronic acid is a treatment option for this deficiency gingival papilla, since it aims to increase tissue volume in the region of loss of interdental papilla, minimally invasive. Aim this study was to describe the application of Hyaluronic acid in a deficient gingival papilla. Case report: Patient presented absence of interdental papilla in the maxillary arch around upper anterior teeth. A comprehensive exam was performed, plus 2D photographs taken with a professional camera coupled to a device for image standardization, and an intraoral scanning with the OMNICAM scanner. Three applications of Hyaluronic acid were performed to fill the black spaces, at an interval of four weeks. The patient was followed-up for three months, and the recovery of papilla was observed. Conclusion: The Hyaluronic acid as gingival filling material can be considered as a treatment option for augmenting interdental papilla in aesthetic area.

Humans , Female , Middle Aged , Esthetics, Dental , Gingiva , Hyaluronic Acid
Arq. bras. oftalmol ; 82(6): 511-513, Nov.-Dec. 2019. graf
Article in English | LILACS | ID: biblio-1038696


ABSTRACT Facial filler injection for soft-tissue augmentation, wrinkle reduction, and rejuvenation has recently become increasingly popular. This procedure is well accepted and widely performed because of its safety and excellent outcomes. However, complications may occur even in the most skilled hands. A 36-year-old female presented with immediate loss of vision in her right eye following the periocular injection of cosmetic hyaluronic acid facial filler into the glabellar region. The visual loss was accompanied by weakness of her left arm. Blindness may complicate cosmetic facial filler injection. The treating physician should have a firm knowledge of the facial vascular anatomy, and the patient should be aware of the potential blinding complications associated with facial filler injection.

RESUMO A injeção de preenchimento facial para o aumento de tecido mole, redução de rugas e rejuvenescimento tornou-se recentemente3 cada vez mais popular. Este procedimento é bem aceito e amplamente realizado devido à sua segurança e excelentes resultados. Porém, complicações podem ocorrer mesmo nas mãos mais habilidosas. Uma mulher de 36 anos apresentou perda da visão no seu olho direito imediatamente após uma injeção periocular de preenchimento facial à base de ácido hialurônico cosmético na região glabelar. A perda visual foi acompanhada de fraqueza no braço esquerdo. A cegueira pode ser uma complicação da injeção de preenchimento facial para fins cosméticos. O médico deve ter um sólido conhecimento da anatomia vascular da face e o paciente deve estar ciente das possíveis complicações associadas à injeção de preenchimento facial.

Humans , Female , Adult , Blindness/chemically induced , Face , Dermal Fillers/adverse effects , Hyaluronic Acid/adverse effects , Retinal Detachment/chemically induced , Injections, Intradermal/adverse effects , Cosmetic Techniques/adverse effects
Rev. bras. ortop ; 54(5): 549-555, Sept.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057930


Abstract Objective To evaluate the clinical and radiological benefits of intra-articular exogenous hyaluronic acid for the treatment of chondral patellar injury. Method Randomized clinical trial with 70 patients divided into 2 groups: those submitted to physical therapy for 3 months, and those submitted to physical therapy associated with the intra-articular administration of 2 mL of hyaluronic acid for the same period, who had anterior knee pain and patellar cartilage injury of grades II or III with no significant bone abnormalities. The functional scores and the characteristics of the physical and imaging exams were evaluated before and 3 and 6 months after the treatment. Result The average age of the patients was 32 ± 7.6 years. Patients from the hyaluronic acid group had better Kujala et al and Lysholm scores, and lower pain scores after 3 and 6 months of treatment when compared to the control group. The incidence of positive Clarke maneuver was lower in the treated group, but there was no difference in the magnetic resonance imaging classification. Conclusion Patients with patellar chondropathy of grades II or III treated with hyaluronic acid and physical therapy had less pain (visual analogue scale, VAS), and better functional results in the Lysholm and Kujala et al questionnaires after 3 and 6 months of treatment compared to patients undergoing physical therapy alone. In addition, the number of cases with a negative Clarke maneuver was larger in the treated group after 6 months of treatment.

Resumo Objetivo Avaliar os benefícios clínicos e radiológicos do uso do ácido hialurônico exógeno intra-articular para o tratamento da lesão condral da patela. Método Ensaio clínico randomizado com 70 pacientes divididos em dois grupos: o de tratamento fisioterápico por 3 meses, e o de tratamento fisioterápico associado à aplicação de 2 ml de ácido hialurônico intra-articular pelo mesmo período, composto por pacientes com dor na região anterior do joelho e lesão de graus II ou III da cartilagem da patela, sem anormalidades ósseas significativas. Foram avaliados os escores funcionais e as características do exame físico e de imagem antes, e após 3 e 6 meses de tratamento. Resultado A idade média dos pacientes foi de 32 ± 7,6 anos. Os pacientes do grupo submetido à aplicação de acido hialurônico apresentaram melhores escores de Kujala et al e de Lysholm, e menor pontuação de dor após 3 e 6 meses de tratamento quando comparados ao grupo controle. A manobra de Clarke positiva foi menor no grupo em que foi feita a aplicação do ácido, mas não houve diferença na classificação da imagem obtida pela ressonância magnética. Conclusão Pacientes com condropatia patelar de graus II ou III do joelho tratados com ácido hialurônico e fisioterapia apresentaram menos dor (escala visual analógica, EVA), e melhores resultados funcionais nos questionários de Lysholm e de Kujala et al após 3 e 6 meses de tratamento quando comparados com os pacientes submetidos apenas à fisioterapia. Além disso, estes pacientes apresentaram manobra de Clarke negativa em maior número após 6 meses de tratamento.

Humans , Male , Female , Adolescent , Adult , Middle Aged , Pain , Patella , Cartilage Diseases , Extravehicular Activity , Chondrocytes , Hyaluronic Acid
J. oral res. (Impresa) ; 8(supl.1): 28-31, ago. 9, 2019. tab
Article in English | LILACS | ID: biblio-1141503


Surgical extraction of impacted lower wisdom teeth is a frequent minor intraoral surgical process. It is regularly linked with aching and postoperative consequences as pain and swelling. The aim of this study is to evaluate the efficacy of two methods in reducing swelling and pain subsequent to the removal of impacted wisdom teeth. This randomized study incorporated 20 patients with impacted wisdom teeth of different surgical complexity. Topical hyaluronic acid gel 2g/2ml with aloe vera (Kin®Care) was given to the patients to be applied to the surgical area three times a day, or diclofenac sodium tablet 50mg (Voltaren®) to be taken every eight hours, for one week. Swelling was estimated using a strip gauge technique, and pain with a visual analogue scale. Evaluations were made on day one of surgical treatment and on 72hrs and one week later. Statistically no significant differences were identified regarding the swelling and pain values between the two treatment groups on the third and seventh day after surgery. Hyaluronic acid gel was as efficient as diclofenac tablets in reducing the two parameters. The use of hyaluronic acid may be advantageous in medically compromised patient such as those with hypertension, chronic asthma, gastric ulcers or in those with any contraindications to using non-steroidal anti-inflammatory drugs, or in pregnant patients to reduce pain and swelling subsequent to impacted wisdom teeth surgery.

Humans , Male , Female , Adolescent , Adult , Young Adult , Pain, Postoperative , Tooth Extraction , Diclofenac/administration & dosage , Cicatrix/drug therapy , Hyaluronic Acid/administration & dosage , Anti-Inflammatory Agents/administration & dosage , Molar, Third