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1.
Arch. argent. pediatr ; 119(3): e193-e201, Junio 2021. tab, ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1223310

ABSTRACT

Se describen como desafíos actuales en mucopolisacaridosis I la necesidad de una clasificación adecuada, vinculándola a las indicaciones terapéuticas; el diagnóstico temprano desde la pesquisa neonatal, sus ventajas y dificultades hasta la sospecha clínica de las formas grave y atenuada; el cuidado de la patología espinal y oftalmológica, desde el diagnóstico, el seguimiento y el tratamiento; las reacciones alérgicas por terapia de reemplazo enzimático, su diagnóstico y tratamiento. Por último, la transición hacia el cuidado adulto


Here we describe the current challenges of mucopolysaccharidosis type I: the need for an adequate classification, establishing its relationship to therapeutic indications; an early diagnosis, from neonatal screening, its advantages and barriers, to clinical suspicion of severe and attenuated forms; spinal and eye disease care, from diagnosis to follow-up and treatment; allergic reactions caused by enzyme replacement therapy, their diagnosis and treatment. And lastly, transition to adult care


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Mucopolysaccharidosis I/diagnosis , Mucopolysaccharidosis I/therapy , Neonatal Screening , Mucopolysaccharidosis I/classification , Eye Diseases/diagnosis , Eye Diseases/therapy , Transition to Adult Care , Hypersensitivity/diagnosis , Hypersensitivity/therapy
2.
Article in Chinese | WPRIM | ID: wpr-877552

ABSTRACT

According to the etiology, allergic diseases are related to wind and heat; according to the pathogenesis, most of allergic diseases are


Subject(s)
Acupuncture Points , Acupuncture Therapy , Hot Temperature , Humans , Hypersensitivity/therapy , Meridians
3.
RELAMPA, Rev. Lat.-Am. Marcapasso Arritm ; 29(3): f:123-l:126, jul.-set. 2016. ilus
Article in Portuguese | LILACS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-831511

ABSTRACT

Cardiopathia fantastica é o termo utilizado para a variante cardíaca da síndrome de Munchausen, condição na qual o paciente busca atendimento médico repetidamente por doenças factícias. Relatamos um caso de síncope induzida por administração inadequada de fármacos cronotrópicos negativos, que resultou em implante de marcapasso definitivo, seguido de reações cutâneas sobre a loja do marcapasso. O acompanhamento da paciente mostrou que as alterações cutâneas eram lesões factícias (Dermatitis artefacta). Apresentamos também uma breve revisão sobre as reações alérgicas a dispositivos cardíacos eletrônicos implantáveis, abrangendo sua fisiopatologia e alternativas terapêuticas disponíveis.


Cardiopathia fantastica is the cardiac variant of Munchausen syndrome, a condition where patients repeatedly seek medical consultation for factitious diseases. We report a case of syncope induced by an inadequate administration of negative chronotropic drugs, which resulted in permanent pacemaker implantation, followed by the appearance of cutaneous reactions over the pacemaker pocket. This patient´s follow-up showed that the cutaneous disease consisted of factitious lesions (Dermatitis artefacta). We also present a brief review on allergic reactions to cardiac implantable electronic devices, including its pathophysiology and available therapeutic strategies.


Subject(s)
Humans , Female , Adult , Pacemaker, Artificial , Diagnosis , Hypersensitivity/physiopathology , Hypersensitivity/therapy , Munchausen Syndrome/diagnosis , Electrocardiography/methods
6.
Indian J Dermatol Venereol Leprol ; 2013 Mar-Apr; 79(2): 151-164
Article in English | IMSEAR | ID: sea-147423

ABSTRACT

Insects are a class of living creatures within the arthropods. Insect bite reactions are commonly seen in clinical practice. The present review touches upon the medically important insects and their places in the classification, the sparse literature on the epidemiology of insect bites in India, and different variables influencing the susceptibility of an individual to insect bites. Clinical features of mosquito bites, hypersensitivity to mosquito bites Epstein-Barr virus NK (HMB-EBV-NK) disease, eruptive pseudoangiomatosis, Skeeter syndrome, papular pruritic eruption of HIV/AIDS, and clinical features produced by bed bugs, Mexican chicken bugs, assassin bugs, kissing bugs, fleas, black flies, Blandford flies, louse flies, tsetse flies, midges, and thrips are discussed. Brief account is presented of the immunogenic components of mosquito and bed bug saliva. Papular urticaria is discussed including its epidemiology, the 5 stages of skin reaction, the SCRATCH principle as an aid in diagnosis, and the recent evidence supporting participation of types I, III, and IV hypersensitivity reactions in its causation is summarized. Recent developments in the treatment of pediculosis capitis including spinosad 0.9% suspension, benzyl alcohol 5% lotion, dimethicone 4% lotion, isopropyl myristate 50% rinse, and other suffocants are discussed within the context of evidence derived from randomized controlled trials and key findings of a recent systematic review. We also touch upon a non-chemical treatment of head lice and the ineffectiveness of egg-loosening products. Knockdown resistance (kdr) as the genetic mechanism making the lice nerves insensitive to permethrin is discussed along with the surprising contrary clinical evidence from Europe about efficacy of permethrin in children with head lice carrying kdr-like gene. The review also presents a brief account of insects as vectors of diseases and ends with discussion of prevention of insect bites and some serious adverse effects of mosquito coil smoke.


Subject(s)
Animals , Bedbugs , Culicidae , Diptera , Humans , Hypersensitivity/diagnosis , Hypersensitivity/epidemiology , Hypersensitivity/therapy , Insect Bites and Stings/diagnosis , Insect Bites and Stings/epidemiology , Insect Bites and Stings/therapy , Pediculus , Randomized Controlled Trials as Topic/methods
8.
Belo Horizonte; s.n; 2012. 119 p. ilus, tab.
Thesis in English, Portuguese | LILACS | ID: lil-681530

ABSTRACT

Este estudo teve como objetivo identificar em uma população de pacientes ortodônticos aqueles que são alérgicos ao níquel, bem como verificar se existem diferenças entre esses indivíduos, considerando especificamente a condição gengival e sanguínea em caráter longitudinal, através da utilização de braquetes convencionais e níquel free no tratamento ortodôntico. A população do estudo foi composta por 80 pacientes, de ambos os gêneros, faixa etária 10 anos e 8 meses a 43 anos e 1 mês. Para diagnóstico da alergia ao níquel, foram realizados testes de contato 1 mês antes do início do tratamento. Quarenta e dois pacientes apresentaram alergia e foram divididos de forma randomizada em 2 grupos...


Subject(s)
Humans , Male , Female , Orthodontic Appliances , Hypersensitivity/diagnosis , Hypersensitivity/therapy , Nickel/adverse effects
10.
Cusco; s.n; 2011. 105 p. tab, graf, ilus.
Thesis in Spanish | LILACS, MTYCI | ID: biblio-880347

ABSTRACT

El presente trabajo abordó la evaluación del efecto inhibitorio sobre la respuesta alérgica del extracto metanótico de Cosmos peucedanifofius (panti) y la determinación de la toxicidad aguda de esta especie. Objetivo: Evaluar el efecto inhibitorio sobre la respuesta alérgica del extracto metanólico de Cosmos peucedanifolius (panti) y determinar la toxicidad aguda. Metodología: Para evaluar el efecto sobre la respuesta alérgica se realizó un estudio cuasi experimental de series cronologías con repetición del estímulo y diseño con un grupo control, realizando las siguientes pruebas: Edema plantar inducido por OVA (ovoalbúmina), Reacción cutánea inducida por Histamina en ratas albinas y Prueba de Anafilaxia Pasiva Cutánea para determinar lgE específica. Y con el objetivo de demostrar la probable toxicidad aguda se usó, un estudio cuasi experimental con pre prueba y post prueba teniendo en cuenta el Método de Lorke. Resultados: Se observó que a dosis de 800mg/Kg existió una inhibición muy buena sobre la inflamación alérgica inducida por Ovoalbúmina de 52 % similar al del fármaco patrón lndometacina. En el ensayo de la evaluación de la reacción cutánea inducida por histamina en ratas albinas se obtuvo buenos resultados a dosis de 400 y 800 mg/kg obteniéndose un buen porcentaje de Inhibición. Finalmente a dosis de 400 mg/Kg se observó una inhibición en la producción de lgE especifica mostrándose de mejor manera a una dilución de e 1/256. En cuanto a la determinación de la toxicidad aguda mediante la prueba de Lorke se determinó que el extracto metanólico de Cosmos peucedanifolius (panti), es poco toxica. Conclusiones: Los resultados de esta investigación constituyen parte de la base experimental pre clínica necesaria para la realización de ensayos clínicos controlados en inmunopatologías como la artritis reumatoide o el asma bronquial entre otras enfermedades relacionadas a la respuesta alérgica.


Subject(s)
Animals , Rats , Asteraceae/toxicity , Hypersensitivity/therapy , Plant Extracts , Phytochemicals
11.
Arch. méd. Camaguey ; 14(3)mayo-jun. 2010. tab
Article in Spanish | LILACS | ID: lil-577907

ABSTRACT

Fundamento: la Inmunoterapia ha sido motivo de controversia y discusión desde que se empezó a utilizar. Las inyecciones pueden desencadenar eventos adversos menores y las reacciones sistémicas son poco frecuentes. Objetivo: evaluar el comportamiento del tratamiento con vacunas antialérgicas en el servicio de alergología del hospital universitario Manuel Ascunce Domenech. Método: se realizó un estudio descriptivo en pacientes alérgicos que acudieron a la consulta de alergología del Hospital Universitario Manuel Ascunce Domenech. Constituyeron el universo los ciento cincuenta pacientes atendidos en este servicio en el período de estudio, la muestra se conformó por cien pacientes que hicieron cambio de vacunas. La información se almacenó en una base de datos confeccionada mediante el programa Excel del Office XP. El procesamiento de los datos incluyó el cálculo de medidas descriptivas para variables cualitativas como las frecuencias absolutas y porcentajes. El procesamiento de la información se realizó mediante el paquete estadístico SPSS versión 6.0. Resultados: se reportaron reacciones adversas en un 17 por ciento entre los diez y ocho a cuarenta y dos años. Las vacunas alergénicas que en su composición tenían extractos de ácaros del Biocen estandarizados, fueron las que dieron reacciones. Las manifestaciones locales fueron roncha, eritema y exacerbación de la enfermedad. Conclusiones: es mayoritario el uso de esquema convencional hasta ahora. En todas las reacciones adversas las vacunas utilizaron ácaros en su composición y no existió reacción sistémica fatal en el estudio.


Background: Immunotherapy has been reason of controversy and discussion since it began to use. Injections may trigger smaller adverse events and systemic reactions are not very frequent. Objective: to evaluate the behavior of the treatment with antiallergic vaccines in the service of allergology of the university hospital Manuel Ascunce Domenech. Method: a descriptive study in allergic patients attended at the consultation of allergology of the University Hospital Manuel Ascunce Domenech was carried out. The universe was constituted by one-hundred fifty patients assisted in this service in the period of study; the sample was conformed to one-hundred patients that made change of vaccines. The information was stored in a database made by means of the Excel program of the Office XP. Data processing included the calculation of descriptive measures for qualitative variables as the absolute frequencies and percentages. The information processing was carried out by means of the statistical package SPSS version 6.0. Results: adverse reactions were reported in 17 percent among the ten and eight to forty-two years. The allergenic vaccines that had mite extracts in its composition of the standardized Biocen, were the ones that gave reactions. Local manifestations were wheal, erythema and exacerbation of the disease. Conclusions: it is majority the use of conventional outline up to now. All adverse reactions of vaccines used mites in its composition and fatal systemic reaction did not exist in the study.


Subject(s)
Humans , Adult , Hypersensitivity/therapy , Immunotherapy , Immunotherapy, Active , Vaccines/therapeutic use , Epidemiology, Descriptive
14.
Säo Paulo med. j ; 128(1): 30-37, Jan. 2010. graf, tab
Article in English | LILACS | ID: lil-547391

ABSTRACT

CONTEXT AND OBJECTIVE: The only effective treatment for patients who have severe reactions after Hymenoptera stings is venom immunotherapy. The aim of this study was to review the literature to assess the effects of venom immunotherapy among patients presenting severe reactions after Hymenoptera stings. DESIGN AND SETTING: Randomized controlled trials in the worldwide literature were reviewed. The manuscript was produced in the Discipline of Allergy and Clinical Immunology, Universidade de São Paulo (USP). METHODS: Randomized controlled trials involving venom immunotherapy versus placebo or only patient follow-up were evaluated. The risk of systemic reactions after specific immunotherapy was evaluated by calculating odds ratios (OR) and their 95 percent confidence intervals. RESULTS: 2,273 abstracts were identified by the keywords search. Only four studies were included in this review. The chi-square test for heterogeneity showed that two studies were homogeneous and could be included in a meta-analysis. By combining the two studies, the odds ratio became significant: 0.29 (0.10-0.87). However, analysis on the severity of the reactions after immunotherapy showed that the benefits may not be so significant because the reactions were mostly similar to or milder than the original reaction. CONCLUSIONS: Specific immunotherapy should be recommended for adults and children with moderate to severe reactions, but there is no need to prescribe it for children with skin reactions alone, especially if the exposure is very sporadic. On the other hand, the risk-benefit relation should always be assessed in each case.


CONTEXTO E OBJETIVO: O único tratamento eficaz para pacientes que têm reações graves após ferroada de Hymenoptera é a imunoterapia com veneno. O objetivo deste estudo foi rever a literatura para avaliar os efeitos da imunoterapia com veneno em pacientes com reações graves após ferroada de Hymenoptera. TIPO DE ESTUDO E LOCAL: Foram revisados na literatura mundial ensaios clínicos controlados e aleatórios. O manuscrito foi realizado na Disciplina de Alergia e Imunologia Clínica, Universidade de São Paulo (USP). MÉTODOS: Ensaios clínicos controlados e aleatórios envolvendo imunoterapia com veneno de Hymenoptera versus placebo ou apenas acompanhamento dos pacientes foram avaliados. Realizada imunoterapia específica, o risco de reações sistêmicas foi avaliado através de cálculo do "odds ratio" e intervalo de confiança de 95 por cento. RESULTADOS: 2.273 resumos foram identificados na busca pelas palavras chave. Apenas quatro estudos foram incluídos nesta revisão. O teste qui-quadrado de heterogeneidade mostrou que dois estudos foram homogêneos e puderam ser incluídos na metanálise. Ao combinar os dois estudos, o "odds ratio" passou a ser significativo: 0.29 (0.10-0.87). Entretanto, ao analisar a gravidade das reações ocorridas após a imunoterapia, observou-se que os benefícios podem não ser tão relevantes, pois as reações foram, na grande maioria, ou mais leves ou semelhantes à reação original. CONCLUSÕES: A imunoterapia específica deve ser recomendada para adultos e crianças com reações moderadas a graves, porém não há necessidade de prescrevê-la para as crianças apenas com reações cutâneas, especialmente se a exposição é muito esporádica. No outro lado, a relação risco-benefício deve ser sempre avaliada em cada caso.


Subject(s)
Humans , Animals , Arthropod Venoms/therapeutic use , Hymenoptera/immunology , Hypersensitivity/therapy , Immunotherapy/methods , Arthropod Venoms/immunology , Bee Venoms/immunology , Bee Venoms/therapeutic use , Chi-Square Distribution , Hypersensitivity/immunology , Insect Bites and Stings/immunology , Insect Bites and Stings/therapy , Odds Ratio , Treatment Outcome , Wasp Venoms/immunology , Wasp Venoms/therapeutic use
15.
Alerg. inmunol. clin ; 27(3/4): 54-57, 2009.
Article in Spanish | LILACS | ID: lil-614169

ABSTRACT

Objetivos: evaluar la eficacia de la inmunoterapia alergeno especifica (IT)en el tratamiento del asma y la rinitis alérgica de niños y adultos, mediante el examen de diferentes metanálisis (MTA) realizados hasta la actualidad.


Subject(s)
Humans , Male , Female , Child , Adult , Allergy and Immunology , Desensitization, Immunologic/methods , Respiratory Tract Diseases/immunology , Hypersensitivity , Hypersensitivity/therapy , Immunotherapy/methods
16.
Acta toxicol. argent ; 16(2): 27-32, dic. 2008. ilus, tab
Article in Spanish | LILACS | ID: lil-564747

ABSTRACT

Menos del 5% de las 20.000 especies estimadas de abejas son sociales y, por lo tanto, pueden producirse ataques masivos o generarse situaciones de riesgo al enjambrar o construir panalescerca o en el interior de domicilios. El veneno de abejas está constituido por una mezcla de substancias con proteínas, siendo las principales enzimas, péptidos y aminas biogénicas. Estas proteínas poseen acciones farmacológicas y alergénicas capaces de provocar cuadros de envenenamiento en el humano y en animales. Se describe el caso clínico de un agricultor que sufrió picaduras por más de 500 abejas con desenlace fatal. Además, se realiza una breve revisión de la literatura sobre el tema.


Less than 5% of the estimated 20,000 species of bees are social, and therefore massive attacks might occur or situations of risk could be generated when swarming to build hives near or inside homes. Bee venom consists of a mixture of substances, mainly protein enzymes, peptides and biogenic amines, these proteins have pharmacological actions and allergens can induce boxes poisoning in humans and animals. We describe the case of a farmer who suffered more than 500 stings by bees with a fatal outcome. In addition, a brief review of the literature is presented.


Subject(s)
Humans , Male , Animals , Aged , Anaphylaxis/complications , Anaphylaxis/physiopathology , Anaphylaxis/chemically induced , Bees , Insect Bites and Stings/mortality , Bee Venoms/poisoning , Hypotension , Hymenoptera/immunology , Hypersensitivity/etiology , Hypersensitivity/therapy
17.
IJI-Iranian Journal of Immunology. 2008; 5 (1): 1-24
in English | IMEMR | ID: emr-86742

ABSTRACT

The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy whether by subcutaneous injection of allergen extract or by oral/sublingual routes modifies peripheral and mucosal T[H]2 responses in favour of T[H]1 responses and augments IL-10 synthesis by T[Regs] both locally and by peripheral T cells. Recent researches into the cellular and molecular basis of allergic reactions have advanced our understanding of the mechanisms involved in allergic diseases. They have also helped the development of innovative approaches that are likely to further improve the control of allergic responses in the future. Novel approaches to immunotherapy that are currently being explored include the use of peptide-based allergen preparations, which do not bind IgE and therefore do not activate mast cells, but reduce both T[H]1 and T[H]2-cytokine synthesis, while increasing levels of IL-10. Alternative strategies include the use of adjuvants, such as nucleotide immunostimulatory sequences derived from bacteria CpG or monophosphoryl lipid A that potentiate T[H]1 responses. Blocking the effects of IgE using anti-IgE such as omalizumab, a recombinant humanized monoclonal antibody that selectively binds to IgE, has been shown to be a useful strategy in the treatment of allergic asthma and rhinitis. The combination of anti-IgE-monoclonal antibody omalizumab with allergen immunotherapy has proved beneficial for the treatment of allergic diseases, offering improved efficacy, limited adverse effects, and potential immune-modifying effects. This combination may also accelerate the rapidity by which immunotherapy induces T[Reg] cells. If allergic diseases are due to a lack of allergen-specific T[Reg] cells, then effective therapies should target the induction and the development of T[Reg] cells producing cytokines such as IL-10


Subject(s)
Humans , Allergens , Hypersensitivity/therapy , Immunoglobulin E , Rhinitis/therapy , Disease Management , Mast Cells , Basophils , Cytokines , Antibody Formation , Immunotherapy
19.
J. appl. oral sci ; 12(4): 267-272, Oct.-Dec. 2004. tab, graf
Article in English | LILACS, BBO | ID: lil-392975

ABSTRACT

A hiperestesia dentinária trata-se de uma condição dolorosa bastante prevalente nas populações mundiais. Várias são as modalidades de tratamento para tal condição, entre elas, os lasers de baixa potência. A proposta deste estudo foi a de verificar a efetividade do laser de diodo de Arseniato de Gálio-Alumínio no tratamento desta condição dolorosa, utilizando-se um placebo como controle. MATERIAIS E MÉTODOS: Foram selecionados 32 pacientes, 22 do sexo feminino e 10 do sexo masculino, com idades entre 20-52 anos. Os 32 pacientes foram distribuídos de maneira aleatória em dois grupos, um tratado e outro controle, um total de 68 dentes compôs a amostra, sendo que 35 compuseram o grupo tratado, e 33 o grupo controle. O grupo tratado foi submetido a seis sessões sucessivas de irradiações em intervalos de 48 a 72 horas, o grupo controle recebeu como placebo aplicações de luz do fotopolimerizador. RESULTADOS: observou-se redução significativa na sensação dolorosa entre a fase inicial e após as seis sessões de tratamento com laser, porém tal redução, também pode ser observada para o grupo controle, submetido ao placebo. CONCLUSAO: a terapia com laser de baixa potência de AsGaAl induz redução estatisticamente significante da sensação dolorosa, após cada uma das aplicações, e entre o início e o final do tratamento, embora não tenha havido, diferença estaticamente significante, ao final do tratamento e após a avaliação mediata dos resultados (após 6 semanas) entre o grupo tratado (laser) e o grupo controle (placebo); dificultando a mensuração real da efetividade do laser e do efeito placebo.


Subject(s)
Hyperesthesia/therapy , Lasers , Hypersensitivity/therapy , Dentin Sensitivity/therapy
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