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1.
Rev. cuba. endocrinol ; 32(1): e271, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1289386

ABSTRACT

Introducción: El síndrome de ovario poliquístico se asocia con frecuencia a alteraciones cardiometabólicas; y su asociación con el fenotipo hipertrigliceridemia-obesidad abdominal ha sido poco estudiada en Cuba. Objetivo: Identificar la frecuencia del fenotipo hipertrigliceridemia-obesidad abdominal en mujeres de edad mediana con síndrome de ovario poliquístico y su asociación con la resistencia a la insulina, trastornos del metabolismo de la glucosa y ateroesclerosis subclínica. Método: Estudio descriptivo, transversal, en 30 mujeres. Se tomaron variables clínicas: edad, peso, talla, índice de masa corporal, circunferencia de cintura y cadera, índice cintura/cadera, tensión arterial, además de concentraciones de glucosa, insulina, colesterol total, triglicéridos, HDL-c y LDL-c, e índice HOMA-IR. La aterosclerosis subclínica se evaluó por doppler carotideo y ecocardiograma (hipertrofia ventricular izquierda y grasa epicárdica). El fenotipo hipertrigliceridemia-obesidad abdominal se definió como triglicéridos elevados (≥ 1,7 mmol/L) y circunferencia de la cintura ≥ 80 cm. Resultados: La frecuencia del fenotipo hipertrigliceridemia-obesidad abdominal fue 43,3 por ciento (13/30). Los valores medios de circunferencia abdominal, tensión arterial, así como de glucemia (p < 0,003), insulinemia (p = 0,028), triglicéridos (p < 0,0001), e índice HOMA-IR (p = 0,012) fueron más elevados en el grupo de mujeres con esa condición. A pesar de no haber diferencias significativas la frecuencia de mujeres con incremento del grosor íntima-media carotídeo y de grasa epicárdica fue superior en aquellas con el fenotipo. Conclusiones: La presencia del fenotipo hipertrigliceridemia-obesidad abdominal es frecuente en mujeres con síndrome de ovario poliquístico, y se asocia con alteraciones del metabolismo de la glucosa y la resistencia a la insulina. Este pudiera ser utilizado en la práctica clínica como un marcador de riesgo para alteraciones cardiometabólicas(AU)


Introduction: The polycystic ovary syndrome is frequently associated to cardiometabolic alterations; and its relation with the hypertriglyceridemic waist phenotype has been poorly studied in Cuba. Objective: Identify the frequency of the hypertriglyceridemic waist phenotype in middle age women with polycystic ovary syndrome and its association with insulin resistance, disorders in the glucose metabolism and subclinical atherosclerosis. Methods: Descriptive, cross-sectional study in 30 women. As clinical variables there were used: age, weight, size, body mass index, waist-hip circumference, waist/hip index, blood pressure; glucose, insulin, total cholesterol, triglycerides, HDL-c and LDL-c concentrations, and HOMA-IR index. Subclinical atherosclerosis was assessed by a carotid doppler and an echocardiogram (left ventricular hypertrophy and epicardial fat). The hypertriglyceridemic waist phenotype was defined as high triglycerides levels (≥ 1.7 mmol/L) and CC ≥ 80 cm. Results: The frequency of the hypertriglyceridemic waist phenotype was 43.3 percent (13/30). The mean values of abdominal circumference, blood pressure, as well as glycemia (p < 0.003), insulinaemia (p = 0.028), triglycerides (p < 0.0001), and HOMA-IR index (p = 0.012) were higher in the group of women with that condition. Although there were not significant differences, the frequency of women with increase of the carotid intima-media thickness and epicardical fat was higher in those with the phenotype. Conclusions: The presence of the hypertriglyceridemic waist phenotype is frequent in women with the polycystic ovary syndrome, and it is associated with alterations of the glucose metabolism and insulin resistance. This can be used in the clinical practice as a marker of risk for cardiometabolic alterations(AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Polycystic Ovary Syndrome/diagnosis , Hypertriglyceridemia/diagnosis , Obesity, Abdominal/etiology , Insulin Resistance , Body Mass Index , Epidemiology, Descriptive , Cross-Sectional Studies
2.
Autops. Case Rep ; 11: e2021243, 2021. tab, graf
Article in English | LILACS | ID: biblio-1285402

ABSTRACT

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome resulting from a hyperactivated immune system. Diverse patient profiles and clinical presentations often result in misdiagnosis. This article describes the varied clinical presentations and autopsy findings in three patients with this entity. The etiopathogenesis of HLH, its disparate and confounding clinical features, the diagnostic criteria, and management principles are also briefly reviewed.


Subject(s)
Humans , Male , Adult , Middle Aged , Lymphohistiocytosis, Hemophagocytic/pathology , Autopsy , Hypertriglyceridemia , Macrophage Activation Syndrome , Ferritins , Immune System
3.
Rev. colomb. gastroenterol ; 35(4): 522-526, dic. 2020. graf
Article in Spanish | LILACS | ID: biblio-1156334

ABSTRACT

Resumen La pancreatitis aguda se considera un proceso inflamatorio del páncreas, el cual resulta de la activación de enzimas digestivas liberadas por esta glándula. Esta entidad patológica está asociada con múltiples etiologías. Caso: varón de 37 años de edad con cuadro de dolor abdominal en hipogastrio irradiado a la espalda. En el examen físico se encontró taquicárdico, hipertenso, con dolor abdominal a la palpación profunda sin signos de irritación peritoneal. Los paraclínicos mostraban una elevación de los reactantes de fase aguda y amilasa pancreática, los estudios imagenológicos mostraban signos de pancreatitis aguda. Discusión: la pancreatitis asociada con hipertrigliceridemia se presenta entre el 0,5 % al 1 % de los casos. La tríada inicial del manejo es dieta absoluta, hidratación intravenosa y analgésicos. En el caso de la hipertrigliceridemia, se puede manejar con hipolipemiantes orales o, en caso de niveles mayores de 1000 mg/dL, se puede usar el recambio plasmático, el cual tiene buena efectividad y disminuye los valores a rangos de normalidad en el 80 % de los casos con la primera sesión.


Abstract Introduction: Acute pancreatitis is considered an inflammatory process of the pancreas, which results from the activation of digestive enzymes released by this gland. This pathological entity is associated with multiple etiologies. Case: 37-year-old male with hypogastrium pain irradiated to the back. On physical examination, the patient was tachycardic, hypertensive, with abdominal pain on deep palpation without signs of peritoneal irritation. Laboratory tests showed an elevation of acute phase reactants and pancreatic amylase, and imaging studies showed signs of acute pancreatitis. Discussion: Pancreatitis associated with hypertriglyceridemia occurs in 0.5 to 1% of cases. The initial management triad is a clear liquid diet, intravenous hydration, and analgesics. Hypertriglyceridemia can be managed with oral hypolipidemic drugs. When levels are higher than 1 000 mg/dL, plasma exchange can be used due to its good effectiveness, decreasing the values to normal ranges in 80% of the cases with the first session.


Subject(s)
Humans , Male , Adult , Pancreatitis , Hypertriglyceridemia , Abdominal Pain
4.
Acta bioquím. clín. latinoam ; 54(3): 267-277, set. 2020. graf, tab
Article in Spanish | LILACS | ID: biblio-1130601

ABSTRACT

Diversos estudios evidencian la asociación entre los niveles elevados del colesterol de LDL (cLDL) y el riesgo de desarrollar enfermedad cardiovascular aterosclerótica. Con el objetivo de comparar los valores de cLDL obtenidos mediante la medición directa y los valores estimados por las ecuaciones de Friedewald tradicional, modificada y de regresión, se valoró el cLDL de 4.621 pacientes mediante el ensayo directo en el autoanalizador ADVIA 1800. Dichos resultados se agruparon en los estados de normolipemia, hipercolesterolemia, hiperlipemia mixta e hipertrigliceridemia y se establecieron diferencias de estimación con las mencionadas fórmulas en el total de la muestra y en los niveles de decisión clínica para el cLDL. Las tres fórmulas presentaron correlación significativa con el método directo en la totalidad de la muestra; sin embargo, cuando los niveles de triglicéridos de las muestras superaron los 200 mg/dL, la diferencia entre la fórmula de Friedewald y el método directo resultó -11,94%, y llegó a -19,13% para el nivel de triglicéridos mayor de 400 mg/dL. Por otro lado, las ecuaciones de Friedewald modificada y de regresión se vieron afectadas en menor cuantía por el nivel de triglicéridos. Las fórmulas de regresión y de Friedewald modificada se constituyen como alternativas razonables para estimar el cLDL y presentan buena concordancia con el método directo, incluso en niveles altos de colesterol y triglicéridos.


Several studies show the association between high LDL cholesterol (LDLc) levels and the risk of developing atherosclerotic cardiovascular disease. In order to compare the LDLc values obtained by direct measurement and the values estimated by the traditional, modified and regression Friedewald equations, the LDLc of 4,621 patients was assessed by means of the direct test in the ADVIA 1800 autoanalyzer.These results were grouped into the states of normolipemia, hypercholesterolemia, mixed hyperlipemia and hypertriglyceridemia, establishing differences in estimation with the aforementioned formulas in the total sample and in clinical decision levels for LDLc. The three formulas showed a significant correlation with the direct method in the entire sample; however, when the triglyceride levels of the samples exceeded 200 mg/dL, the difference between Friedewald's formula and the direct method was -11.94% reaching -19,13% for the triglyceride level greater than 400 mg/dL, while the modified Friedewald and regression equations were affected to a lesser extent by the triglyceride level. Regression and modified Friedewald formulas are constituted as reasonable alternatives to estimate LDLc and have good agreement with the direct method, even at high cholesterol and triglyceride levels.


Varios estudos evidenciam a associacao entre niveis elevados do colesterol LDL (cLDL) e o risco de desenvolver doenca cardiovascular aterosclerotica. Visando comparar os valores de cLDL obtidos atraves da medicao direta e os valores estimados pelas equacoes de Friedewald tradicional, modificada e de regressao, o cLDL de 4.621 pacientes foi avaliado por meio do teste direto no analisador automatico ADVIA 1800. Tais resultados foram agrupados nos estados de normolipemia, hipercolesterolemia, hiperlipemia mista e hipertrigliceridemia, estabelecendo-se diferencas na estimativa com as formulas mencionadas no total da amostra e nos niveis de decisao clinica para cLDL. As tres formulas apresentaram correlacao significativa com o metodo direto em toda a amostra, no entanto, quando os niveis de triglicerideos das amostras excederam 200 mg/dL, a diferenca entre a formula de Friedewald e o metodo direto foi de -11,94% atingindo -19,13% para o nivel de triglicerideos superior a 400 mg/dL. Por outra parte, as equacoes de Friedewald modificada e de regressao foram afetadas em menor grau pelo nivel de triglicerideos. As formulas de regressao e de Friedewald modificada se constituem como alternativas razoaveis para estimar o cLDL, e apresentam boa concordancia com o metodo direto, mesmo em niveis elevados de colesterol e triglicerideos.


Subject(s)
Triglycerides , Hypertriglyceridemia , Cholesterol , Hypercholesterolemia , Hyperlipidemias , Hyperlipoproteinemia Type V , Cholesterol, LDL , Cholesterol, LDL/blood , Patients , Association , Cardiovascular Diseases , Disease , Risk , Minors , Methods
5.
Rev. colomb. gastroenterol ; 35(2): 226-231, abr.-jun. 2020. tab
Article in Spanish | LILACS | ID: biblio-1126313

ABSTRACT

Resumen Introducción: la pancreatitis aguda es una entidad de alta incidencia e impacto a nivel mundial. Presenta múltiples causas dentro de las cuales las más frecuentes son la obstrucción de la vía biliar, el consumo de alcohol y, en tercer orden, la hipertrigliceridemia. Esta última se entiende como aquellos niveles séricos de triglicéridos >1000 mg/dL. Dicho escenario representa entre el 1 y el 7 % del total de los casos. Metodología: presentamos un caso de pancreatitis aguda secundaria a hipertrigliceridemia severa, manejada con plasmaféresis. Se realiza una revisión de la literatura sobre las condiciones, indicaciones y ventajas de esta estrategia terapéutica. Conclusiones: en casos escogidos, la plasmaféresis es una estrategia de manejo segura y efectiva en el tratamiento de pacientes con pancreatitis aguda secundaria a hipertrigliceridemia severa.


Abstract Introduction: Globally, acute pancreatitis has a high incidence and a large. Among its numerous causes, the most frequent are obstructions of the bile duct, alcohol consumption and hypertriglyceridemia (triglyceride serum levels higher than 1000 mg/dL). Hypertriglyceridemia accounts for 1% to 7% of the total cases. Methodology: We present a case of acute pancreatitis secondary to severe hypertriglyceridemia which was managed with plasmapheresis. We include a review of the literature on the conditions, indications and advantages of this therapeutic strategy. Conclusions: In selected cases, plasmapheresis is a safe and effective management strategy for patients with acute pancreatitis secondary to severe hypertriglyceridemia.


Subject(s)
Humans , Male , Adult , Pancreatitis , Therapeutics , Hypertriglyceridemia , Plasmapheresis , Incidence , Literature
6.
Demetra (Rio J.) ; 15(1): 48609, jan.- mar.2020. tab
Article in English, Portuguese | LILACS | ID: biblio-1363097

ABSTRACT

Objetivo: Este artigo investiga a prevalência de cintura hipertrigliceridêmica em bancários e sua associação com fatores socioeconômicos, laborais, comportamentais, antropométricos e de condições de saúde. Método: trata-se de um estudo transversal com 525 bancários. Para avaliação do fenótipo cintura hipertrigliceridêmica foi considerada a associação de circunferência da cintura e hipertrigliceridemia. Resultados: A investigação resultou em uma prevalência de fenótipo de 19,4%, sendo maior em homens, pessoas em idades avançadas, que vivem maritalmente e que trabalham na agência há mais de cinco anos. O fenótipo também se associou ao excesso de peso, HDL-c (high density lipoprotein) baixo, hiperlipidemia mista, elevada relação triglicerídeos/HDL-c e hipertensão arterial. Ter mais de 50 anos e estar acima do peso aumentava as chances de os bancários apresentarem o fenótipo. Ser do sexo feminino e ter níveis adequados de HDL-c mostraram-se fatores de proteção contra o fenótipo. Conclusão: A prevalência de cintura hipertrigliceridêmica entre bancários é alta e associa-se principalmente ao excesso de peso e perfil lipídico desfavorável desta população. (AU)


Objective: This paper investigates the prevalence of hypertriglyceridemic waist in bank workers and its association with socioeconomic, labor, behavioral, anthropometric and health condition factors. Method: This is a cross-sectional study based on information from 525 bank workers. To investigate the hypertriglyceridemic waist phenotype, it was necessary to consider the association between waist circumference and high levels of serum triglycerides. Results: The investigation resulted in a phenotype prevalence of 19.4%, being higher in men, elderly, married and working in the bank for more than five years. The phenotype was also associated with overweight, low HDL-c (high-density lipoprotein), mixed hyperlipidemia, high triglyceride/HDL-c ratio and arterial hypertension. Being over 50 years of age and being overweight increased the chances of the bankers presenting the phenotype. Being female and having adequate levels of HDL-c were shown to be protective factors against the phenotype. Conclusion: The prevalence of hypertriglyceridemic waist is high and is associated mainly with the excess weight and unfavorable lipid profile of this population. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Phenotype , Waist Circumference , Hypertriglyceridemic Waist , Socioeconomic Factors , Hypertriglyceridemia , Health Status , Overweight , Hyperlipidemias , Cholesterol, HDL , Occupational Groups
7.
Rev. cuba. salud pública ; 46(1): e1849, ene.-mar. 2020. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1126828

ABSTRACT

Introducción: La hipertrigliceridemia es una forma de dislipidemia frecuentemente asociada con enfermedad ateroesclerótica. La obesidad se encuentra entre los factores de riesgo implicados en la aceleración del proceso ateroesclerótico. El desorden fisiopatológico provocado por el tejido adiposo disfuncionante es causa de afectaciones cardiovasculares, endocrinometabólicas y neoplásicas. Objetivo: Identificar la relación entre la presencia de hipertrigliceridemia con la circunferencia de la cintura en adultos mayores, a partir de la evaluación del índice de masa corporal, cintura-cadera y la presencia de hipertrigliceridemia, según la edad y el sexo. Métodos: Estudio descriptivo transversal realizado entre 2015-2017, con una muestra de 386 adultos de ambos sexos. La recogida de datos se realizó según el modelo de recolección del dato primario del Centro de Investigación y Referencias de Aterosclerosis de La Habana. El análisis de los datos se realizó con el programa SPSS v16- y las técnicas de Chi-Square. Resultados: La edad media de la muestra fue de 55,5 años y el 70,6 por ciento eran mujeres. El 57 por ciento presentaba hipertrigliceridemia y el 63,4 por ciento un índice de masa corporal aumentado, un 37,8 por ciento de personas con sobrepeso y un 26,5 por ciento con obesidad. El índice de masa corporal fue superior en mujeres perimenopáusicas, en las que tuvieron el predominio de cintura hipertrigliceridémica. Se observó un incremento de obesidad abdominal con la edad. Conclusiones: Los factores de riesgo cardiovascular, así como, la asociación existente entre los triglicéridos y la medida de la circunferencia de cintura, requiere una valoración sistemática por sexo y edad. La consulta de enfermería de la Atención Primaria es un lugar ideal para promover estrategias de intervención para monitorizar el riesgo clínico cardiovascular a través de los diferentes parámetros antropométricos(AU)


Introduction: Hypertriglyceridemia is a form of dyslipidemia frequently associated with the atherosclerotic disease. Obesity is among the risk factors involved in the acceleration of the atherosclerotic process. The pathophysiologic disorder caused by the dysfuncional adipose tissue is the cause of cardiovascular, endocrinometabolic and neoplastic diseases. Objective: To identify the relationship between the presence of hypertriglyceridemia and waist circumference in older adults from the assessment of the body mass index, waist-hip ratio and the presence of hypertriglyceridemia, according to age and gender. Methods: Descriptive, cross-sectional study conducted from 2015 to 2017, with a sample of 386 adults of both sexes. Data collection was performed according to the model of primary data collection of the Center for Research and of Atherosclerosis References of Havana. The data analysis was performed with the SPSS v16- software and the Chi-Square techniques. Results: The average age of the sample was 55.5 years and 70.6 percent were women. The 57 percent had hypertriglyceridemia and 63.4 percent an increased body mass index; 37.8 percent of the people had overweight and 26.5 percent had obesity. Body mass index was higher in perimenopausal women, who had a predominance of hypertriglyceridemic waist. It was noticed an increase of the abdominal obesity with aging. Conclusions: The cardiovascular risk factors as well as the association between triglycerides and the measure of waist circumference require a systematic assessment by sex and age. The nursing consultation in Primary Care is an ideal place to promote intervention strategies to monitor the cardiovascular clinical risk through the different anthropometric parameters(AU)


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Primary Health Care , Hypertriglyceridemia/epidemiology , Obesity, Abdominal/epidemiology , Obesity/epidemiology , Chi-Square Distribution , Epidemiology, Descriptive , Cross-Sectional Studies
8.
Article in English | WPRIM | ID: wpr-811146

ABSTRACT

BACKGROUND: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia.METHODS: This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment.RESULTS: After 8 weeks of treatment, the percent changes from baseline in TG (−29.8% vs. 3.6%, P<0.001) and non-HDL-C (−10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n=103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P<0.001). The incidence of adverse events did not differ between the two groups.CONCLUSION: The addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia.


Subject(s)
Adult , Atorvastatin , Cholesterol , Cholesterol, LDL , Dyslipidemias , Fasting , Fatty Acids, Omega-3 , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Hypertriglyceridemia , Incidence , Lipoproteins , Triglycerides
9.
Article in English | WPRIM | ID: wpr-811140

ABSTRACT

BACKGROUND: Soybean food consumption has been considered as a possible way to lower incidence of cardiometabolic syndrome (CMS) among Asians. However, results from studies investigating its efficacy on CMS in Asians have been inconsistent.METHODS: We analyzed the association between soybean intake frequency and prevalence of CMS based on data from the Korea National Health and Nutrition Examination Survey 2007 to 2011. Data of 9,287 women aged 20 to 64 years were analyzed. Food frequency questionnaire was used to assess soybean food consumption frequency. General linear model and multivariable logistic regression model were used to examine the association of soybean intake quintile with CMS and its risk factors. Least square means of metabolic factors mostly showed no significant relevance except liver indexes.RESULTS: Compared to participants in the 1st quintile (<2 times/week of soybean food), odds ratios (OR) for CMS and abdominal obesity (AO) in the 4th quintile (8.5 times/week<soybean food≤17 times/week) were 0.73 (95% confidence interval [CI], 0.57 to 0.95) and 0.72 (95% CI, 0.58 to 0.90), respectively. After excluding Tofu products, ORs of CMS, AO, high blood pressure, and hypertriglyceridemia were lower than those without excluding Tofu products. However, results still did not show significant inverse linear trend across frequency quintiles.CONCLUSION: Our findings suggest that soybean intake of 8.5 to 17 times/week was inversely associated with CMS in Korean women. The relation between soybean intake >17 times/week and CMS varied depending on soybean food items.


Subject(s)
Asian Continental Ancestry Group , Diabetes Mellitus , Eating , Female , Humans , Hypertension , Hypertriglyceridemia , Incidence , Korea , Linear Models , Liver , Logistic Models , Nutrition Surveys , Obesity, Abdominal , Odds Ratio , Prevalence , Risk Factors , Soy Foods , Soybeans
10.
Article in Chinese | WPRIM | ID: wpr-828902

ABSTRACT

OBJECTIVE@#To investigate the triglyceride (TG)-lowering effects of PCSK9 inhibitor in patients with in different baseline triglyceride levels.@*METHODS@#Between February, 2019 and March, 2020, a total of 59 patients were treated with PCSK9 inhibitor (Evolocumab) in 5 hospitals, including Nanfang Hospital, Guangdong Provincial People's Hospital, First Affiliated Hospital of Sun Yat-sen University, Foshan Nanhai District People's Hospital and Yulin First People's Hospital. According to baseline triglyceride levels, the patients were divided into normal TG group (< 1.70 mmol/L, =24), mild hypertriglyceridemia group (1.70-2.29 mmol/L, =11), moderate hypertriglyceridemia group (2.30-5.63 mmol/L, =13), and severe hypertriglyceridemia group (≥5.64 mmol/L, =11), and the changes in TG level after the treatment were compared among the 4 groups.@*RESULTS@#In the groups with normal and mildly elevated baseline TG level, the patients did not show significant changes in TG levels after the treatment. In patients with moderately and severely elevated baseline TG levels, treatment with PCSK9 inhibitor significantly reduced their TG levels ( < 0.005).@*CONCLUSIONS@#PCSK9 inhibitor has a significant TG-lowering effect in patients with moderate to severe hypertriglyceridemia but not in patients with only mildly elevated baseline TG level.


Subject(s)
Humans , Hypertriglyceridemia , Hypolipidemic Agents , Proprotein Convertase 9 , Triglycerides
11.
Rev. cuba. reumatol ; 21(3): e106, sept.-dic. 2019. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1093832

ABSTRACT

Introducción: la artritis reumatoide es una enfermedad sistémica, de etiología desconocida, caracterizada por provocar inflamación crónica, cursa con manifestaciones articulares, extrarticulares y comportamiento clínico variable. Objetivo: caracterizar los factores de riesgo para la aparición de aterosclerosis en pacientes con artritis reumatoide e identificar su relación con el tiempo de diagnóstico, actividad inflamatoria y tratamiento. Método: se realizó estudio descriptivo transversal, en pacientes con artritis reumatoide atendidos en el Centro de Reumatología del Hospital Docente Clínico Quirúrgico 10 de Octubre entre febrero 2016 y junio 2017. Resultados: la mayor frecuencia fue para el sexo femenino, el rango etario 45-54 años. Se observó placa ateromatosa en 37.2 por ciento y engrosamiento complejo íntima media en el 15.4 por ciento. Los factores de riesgo que mostraron asociación con la presencia de placa fueron: hipertrigliceridemia (p= 0.000), hipercolesterolemia (p= 0.000), Diabetes Mellitus (p= 0.027) y los niveles elevados de proteína C Reactiva (p= 0.003). Conclusiones: los factores de riesgo tradicionales que presentaron significación estadística fueron la hipercolesterolemia, hipertrigliceridemia y la Diabetes Mellitus. La presencia de más de un factor elevó la frecuencia de alteraciones en el eco doppler; existió asociación entre la elevación de los niveles de PCR y la presencia de alteraciones del eco doppler. Se constató en aquellos pacientes con alteraciones eco doppler carotídeo relación con el tiempo de evolución, actividad de la enfermedad y dosis acumulada de esteroides(AU)


Introduction: rheumatoid arthritis is a systemic disease, of unknown etiology, characterized by chronic inflammation; It presents with joint, extra-articular manifestations and variable clinical behavior. Objective: to characterize the risk factors for the appearance of atherosclerosis in patients with rheumatoid arthritis and to identify their relationship with the time of diagnosis, inflammatory activity and treatment. Method: a cross-sectional, descriptive study was conducted in patients with rheumatoid arthritis treated at the Rheumatology Center of the Surgical Clinical Teaching Hospital 10 de Octubre in the period between February 2016 and June 2017. Results: the highest frequency was for the female sex, the age range 45-54 years. Atheromatous plaque was observed in 37.2 percent and intimal complex thickening in 15.4 percent. The risk factors that showed association with the presence of plaque were: hypertriglyceridemia (p= 0.000), hypercholesterolemia (p= 0.000), Diabetes Mellitus (p= 0.027) and high levels of C-reactive protein (p= 0.003) Conclusions: the traditional risk factors that presented statistical significance were hypercholesterolemia, hypertriglyceridemia and Diabetes Mellitus. The presence of more than one traditional risk factor increased the frequency of alterations in Doppler echo; There was an association between the elevation of C-Reactive Protein levels and the presence of Doppler echo alterations. It was found in those patients with carotid echo Doppler alterations, relationship with the time of evolution, activity of the disease and cumulative dose of steroids(AU)


Subject(s)
Humans , Arthritis, Rheumatoid/complications , C-Reactive Protein/analysis , Hypertriglyceridemia/complications , Polymerase Chain Reaction/methods , Diabetes Mellitus/diagnosis , Atherosclerosis/complications , Hypercholesterolemia/complications , Epidemiology, Descriptive , Cross-Sectional Studies , Risk Factors
12.
Rev. cuba. angiol. cir. vasc ; 20(3): e56, jul.-dic. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1093136

ABSTRACT

Introducción: El perfil lipídico mínimo está relacionado con la enfermedad vascular de tipo aterosclerótica, pero se desconoce cuál es el tipo de perfil más frecuente en los adultos y el tipo de riesgo que representan para la enfermedad vascular periférica de los miembros inferiores. Objetivo: Determinar si el perfil lipídico mínimo sirve para diagnosticar el riesgo de enfermedad vascular periférica de los miembros inferiores. Métodos: Se trabajó con 533 muestra sanguíneas de personas adultas de diferentes municipios de la provincia La Habana. Se cuantificaron las concentraciones de colesterol total y de triglicéridos. Se calculó la media y la desviación estándar. Se diagnosticó y clasificó la hiperlipemia, se identificó el riesgo de enfermedad vascular periférica de los miembros inferiores y su asociación con la hiperlipemia. Se trabajó con un nivel de confiabilidad del 95 por ciento (a=0,05). Resultados: Los perfiles lipídicos mínimos más frecuentes fueron: el hipercolesterolemia leve (46,0 por ciento) y la hipertrigliceridemia (22,6 por ciento). El 53,8 por ciento presentó riesgo de enfermedad vascular periférica de los miembros inferiores entre potencial (24,8 por ciento) y alto (29,0 por ciento). Existió una asociación entre la hiperlipemia y la presencia de enfermedades vasculares periféricas de los miembros inferiores (chi cuadrada= 120,4; p= 0,00000). Se detectó que el 50 por ciento de las personas requería de un tratamiento hipolipemiante. Conclusión: El perfil lipídico mínimo sirve para diagnosticar el tipo de riesgo de enfermedad vascular periférica de los miembros inferiores. Se observó una fuerte asociación de dicha enfermedad con la presencia de hiperlipemia(AU)


Introduction: The minimum lipid profile is related to atherosclerotic vascular disease, but it is not known what is the most common type in adults and the kind of risk it represent for peripheral vascular disease of the lower limbs. Objective: To determine if the minimum lipid profile is used to diagnose the risk of peripheral vascular disease of the lower limbs. Methods: It was carried out a study with 533 blood sample of adults from different municipalities in Havana province. Concentrations of total cholesterol and triglycerides were quantified. Average and standard deviation were calculated. Hyperlipidemia was diagnosed and classified, the risk of peripheral vascular disease of the lower limbs and the association of the latter with hyperlipidemia were identified. The level of reliability used was of 95 percent (a= 0.05). Results: The most common minimum lipid profiles were: mild hypercholesterolemia (46 percent) and hypertriglyceridemia (22.6 percent). 53.8 percent presented a risk of peripheral vascular disease of the lower limbs between potential (24.8 percent) and high (29 percent). There was a relation between the hyperlipidemia and the presence of peripheral vascular diseases of the lower limbs (chi-cudrada= 120.4, p= 0.00000). It was detected that 50 percent of the people required a hypolipidemic treatment. Conclusion: The minimum lipid profile is used to diagnose the risk's type of peripheral vascular disease of the lower limbs, observing a strong relation of the latter with the presence of hyperlipidemia(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Vascular Diseases , Peripheral Vascular Diseases , Lower Extremity , Hypercholesterolemia , Triglycerides , Hypertriglyceridemia , Hyperlipidemias
13.
Cambios rev. méd ; 18(2): 13-17, 2019/12/27. tabs.
Article in Spanish | LILACS | ID: biblio-1097601

ABSTRACT

INTRODUCCIÓN. El hipotiroidismo e hipertiroidismo, constituyen patologías tiroideas, que si no reciben tratamiento apropiado llegan a provocar alteraciones sistémicas, siendo una de las principales las cardiovasculares. OBJETIVO. Conocer la influencia que tiene el hipotiroidismo e hipertiroidismo como factores de riesgo para el desarrollo de enfermedad cardiovascular. MATERIALES Y MÉTODOS. Estudio retrospectivo de enfoque cuantitati-vo; desarrollado en una población y muestra conocida de 111 pacientes, que acudieron al Servicio de Endocrinología del Hospital Manuel Ygnacio Monteros Valdivieso de la ciudad de Loja, atendidos en el año 2015. RESULTADOS. Predominó el sexo femenino, con un 20,72% (23; 69) en el grupo etario de 61 a 70 años de las pacientes hipotiroideas; y las de 51 a 60 años en 5,40% (6; 11) de las hipertiroideas. De acuerdo a los parámetros que pue-den condicionar mayor riesgo cardiovascular, el sobrepeso y obesidad presentaron una mayor frecuencia para hipotiroidismo en 67,70% (65; 111) e hipertiroidismo en un 66,67% (10; 111). El riesgo bajo cardiovascular prevaleció en 75,00% (72; 96) de la población hipo-tiroidea y 93,33% (14; 15) de la hipertiroidea. La hipertensión arterial fue la patología car-diovascular diagnosticada con mayor frecuencia sobre todo en los pacientes hipotiroideos representado por el 14,58% (14; 19). CONCLUSIÓN. Estas patologías, de no controlarse pudieran condicionar en la población de estudio un mayor riesgo cardiovascular.


INTRODUCTION. Hypothyroidism and hyperthyroidism, constitute thyroid pathologies, that if they do not received appropriate treatment, cause systematic alterations, treatment, cause systematic cardiovascular diseases being one of the main ones. OBJECTIVE. Know the influence of hypothyroidism and hyperthyroidism as risk factors for the development of cardiovascular disease. MATERIALS AND METHODS. Retrospective study of quantitative approach; developed in a population and known sample of 111 patients, who went to the Endocrinology Service of the Manuel Ygnacio Monteros Valdivieso Hospital in the city of Loja, attended in 2015. RESULTS. The female sex predominated, with 20,72% (23; 69) in the age group predominated 61 to 70 years of age in 5,40% (6; 11) of hyperthyroids. According to the parameters that may condition higher cardiovascular risk, overweight and obesity presented a higher frequency for hypothyroidism in 67,70% (65; 111) and hyperthyroidism in 66,67% (10; 111). Low cardiovascular risk prevailed in 75,00% (72; 96) of the hypothyroid population and 93,33% (14; 15) of the hyperthyroid population. Arterial hypertension was the most frequently diagnosed cardiovascular disease, especially in hypothyroid patients by 14,58% (14; 19). CONCLUSION. These pathologies, if not controlled, could condition a higher cardiovascular risk in the study population.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Cardiovascular Diseases , Body Mass Index , Risk Factors , Essential Hypertension , Hyperthyroidism , Hypothyroidism , Thyroid Diseases , Hypertriglyceridemia , Overweight , Hypercholesterolemia , Obesity
15.
Salud pública Méx ; 61(5): 619-628, sep.-oct. 2019. tab
Article in English | LILACS | ID: biblio-1127325

ABSTRACT

Abstract: Objective: Evaluate association of dietary patterns with metabolic syndrome (MetS) and metabolic markers. Materials and methods: 654 adolescents from Guadalajara, Jalisco, participated in a cross-sectional study. Diet was evaluated using a food frequency questionnaire; 24 food groups were integrated, and dietary patterns were derived using cluster analysis. MetS was defined according to International Diabetes Federation (IDF), Cook and colleagues, Ford and colleagues, and de Ferranti and colleagues criteria. Results: Dietary patterns identified were: "DP1", "DP2", and "DP3". Among males, "DP3" was associated with MetS (Cook and collaborators) (OR, 12.14; 95%CI, 1.66-89.05), hypertriglyceridemia (OR, 3.89; 95%CI, 1.01-15.07), and insulin resistance (OR, 6.66; 95%CI, 1.12-39.70). "DP2" was associated with abdominal obesity (OR, 5.11; 95%CI, 1.57-16.66). Conclusions: "DP3" entertained a greater risk of MetS, hypertriglyceridemia, and insulin resistance, while "DP2" possessed a greater risk of abdominal obesity among adolescent males.


Resumen: Objetivo: Evaluar la asociación de patrones dietarios (PD) con síndrome metabólico (SM) y marcadores metabólicos. Material y métodos: Estudio transversal con 654 adolescentes. Dieta evaluada con el cuestionario "frecuencia de consumos de alimentos"; se identificaron 24 grupos de alimentos, para obtener PD mediante análisis de conglomerados. SM se definió según los criterios: Federación de Diabetes Internacional (IDF), Cook y colaboradores, Ford y colaboradores y Ferranti y colaboradores. Resultados: Se identificaron tres PD: "PD1", "PD2" y "PD3". En hombres, "PD3" se asoció con SM (Cook y colaboradores) (RM, 12.14; IC95%, 1.66-89.05), hipertrigliceridemia (RM, 3.89; IC95%, 1.01-15.07) y resistencia a insulina (RM, 6.66; IC95%, 1.12-39.70). El patrón "PD2" se asoció con obesidad abdominal (RM, 5.11; IC95%, 1.57-16.66). Conclusiones: El patrón "PD3" aumenta el riesgo de SM, hipertrigliceridemia y resistencia a insulina y el "PD2" el riesgo de obesidad abdominal en adolescentes hombres.


Subject(s)
Humans , Male , Female , Adolescent , Metabolic Syndrome/etiology , Feeding Behavior , Energy Intake , Insulin Resistance , Hypertriglyceridemia/etiology , Logistic Models , Odds Ratio , Sex Factors , Cross-Sectional Studies , Obesity, Abdominal/etiology , Fast Foods/adverse effects , Pediatric Obesity/epidemiology , Portion Size , Food/classification
16.
Gac. méd. Méx ; 155(5): 500-503, Sep.-Oct. 2019. graf
Article in English | LILACS | ID: biblio-1286550

ABSTRACT

The metabolic syndrome describes a group of signs that increase the likelihood for developing type 2 diabetes mellitus, cardiovascular diseases and some types of cancer. The action of insulin depends on its binding to membrane receptors on its target cells. We wonder if blood insulin could travel bound to proteins and if, in the presence of hyperinsulinemia, a soluble insulin receptor might be generated. We used young adult Wistar rats (which have no predisposition to obesity or diabetes), whose drinking water was added 20 % of sugar and that were fed a standard diet ad libitum for two and six months. They were compared with control rats under the same conditions, but that had running water for consumption. At two months, the rats developed central obesity, moderate hypertension, high triglyceride levels, hyperinsulinemia, glucose intolerance and insulin resistance, i.e., metabolic syndrome. Electrophoresis of the rats’ plasma proteins was performed, followed by Western Blot (WB) for insulin and for the outer portion of the insulin receptor. The bands corresponding to insulin and to the receptor external part were at the same molecular weight level, 25-fold higher than that of free insulin. We demonstrated that insulin, both in control animals and in those with hyperinsulinemia, travels bound to the receptor outer portion (ectodomain), which we called soluble insulin receptor, and that is released al higher amounts in response to plasma insulin increase; in rats with metabolic syndrome and hyperinsulinemia, plasma levels are much higher than in controls. Soluble insulin receptor increase in blood might be an early sign of metabolic syndrome.


Subject(s)
Humans , Animals , Rats , Insulin Resistance/physiology , Receptor, Insulin/metabolism , Metabolic Syndrome/etiology , Hyperinsulinism/metabolism , Insulin/metabolism , Hypertriglyceridemia/etiology , Rats, Wistar , Glucose Intolerance/etiology , Metabolic Syndrome/metabolism , Diabetes Mellitus, Type 2/etiology , Disease Models, Animal , Obesity, Abdominal/etiology , Hypertension/etiology , Insulin/blood
17.
Prensa méd. argent ; 105(7): 385-391, agosto 2019. tab, graf
Article in Spanish | LILACS, BINACIS | ID: biblio-1022101

ABSTRACT

Introducción: Estudio observacional, prospectivo, abierto, multicéntrico. Se evaluaron 117 pacientes reclutados en 16 centros. Se incluyeron pacientes mayores de 18 años, con hipertrigliceridemia mayor a 200 mg/dl (asociado o no a dislipidemia mixta) que ya estén recibiendo ácido fenofíbrico 105 mg/día desde hace por lo menos 8 y no más de 12 semanas. El cronograma de visitas consistió en una visita inicial (entre 8 a 12 semanas de iniciado el tratamiento con ácido fenofíbrico) y una visita final (8 semanas después de la visita inicial). Resultados: La efectividad fue evaluada a partir de valores de laboratorio y su respuesta al tratamiento, (descenso de niveles séricos de triglicéridos principalmente y descenso de niveles séricos de LDL, y ascenso de niveles séricos de HDL), comparando valores basales y controles de laboratorio en la visita inicial y final. Efectividad: 106 pacientes evaluables. Triglicéridos: Basal: 368,44 ± 165,39 mg/dl; Día 60: 246,30 ± 171,43 mg/dl; Día 120: 180,92 ± 130,59 mg/dl. Anova: p<0,05. LDL: Basal: 144,24 ± 42,33 mg/dl; Día 60: 121,73 ± 38,24 mg/dl; Día 120: 116,08 ±39,81 mg/dl. Anova: p < 0,05. HDL: Basal 41,58 ± 14,09 mg/dl; Día 60: 43,74 ±13,78 mg/dl; Día 120: 46,43 ± 16,09 mg/dl. Anova: p: <0,05. Seguridad: 117 pacientes evaluables. Eventos adversos: 9 pacientes (7,69%) Conclusiones: En nuestro grupo de pacientes evaluados, la administración de 105 mg de Acido Fenofíbrico al día resultó efectiva para disminuir los valores séricos de Triglicéridos y LDL, además de aumentar el HDL. El perfil de seguridad fue aceptable (AU)


Introduction: Observational, prospective, open, multicenter clinical study. One hundred and seventeen (117) patients were recruited from 16 sites. Inclusion criteria: both sexes patients elder than 18 years old with bypertriglyceridemia values higher than 200 mg/dl (related or not to mixed dylipidemia), who had to be taking 105 mg/day of fenofibric acid sinde - at least - 8 weeks and no more than 12 weeks. Study schedule: Baseline visit between 8 and 12 weeks after fenofibric acid strting tretment. Last clinical trial visit: 8 weeks after the baseline one. Results: Effectiveness was evaluated considering laboratory clinical values achieved after treatment. It means: as primary outome it was considerd lower triglycerides serum levels and, as a secondary one, lower LDL and higher HDL serum levels. Laboratory values were compared between the ones from baseline visit and the ones from last visit. Effectiveness: 106 evaluable patients. Triglycerides: Baseline: 368,44 ± 165,39 mg/dl: Day 60: 246,30 ±171,43 mg/dl. Day 120: 180,92 ± 130,59 mg/dl. Anova: p< 0.05. LDL: Baseline: 144,24 ± 42,33 mg/dl: Day 60: 121,73 ± 38,24 mg/dl; Day 120: 116,08 ± 39,81 mg/dl. Anova: p<0,05. HDL: Baseline: 41,58 ± 14,09 mg/dl: Day 60: 43,74 ± 13,78 mg/dl. Day 120: 46,43 ± 16.09 mg/dl. Anova: p<0.05. Safety: 117 evaluable patients: Adverse Events: 9 patients (7,69%). Conclusion: The administration of 105 mg/day of fenofibric acid to the evaluable patients recruited for this clinical study, showed to be effective not only to decrease triglycerides and LDL serum levels, but also to increase HDL, cholesterol values. Patient safety was acceptaable (AU)


Subject(s)
Humans , Fenofibrate , Hypertriglyceridemia , Prospective Studies , Treatment Outcome , Dyslipidemias , Observational Study
18.
J. bras. nefrol ; 41(1): 142-144, Jan.-Mar. 2019. graf
Article in English | LILACS | ID: biblio-1002417

ABSTRACT

ABSTRACT Atheroembolic renal disease (AERD) is a kidney manifestation of atherosclerosis as a systemic disease. AERD is defined as a renal impairment secondary to embolization of cholesterol crystals with consequent occlusion of renal vascularization. The current case report describes one patient with multiple risk factors but without any inciting event history who presents a very atypical clinical course of a severe and massive atheroembolic disease that developed spontaneously and silently.


RESUMO A doença renal ateroembólica (DRAE) é uma manifestação renal da aterosclerose enquanto patologia sistêmica. A DRAE é definida como uma disfunção renal secundária à embolização de cristais de colesterol seguida da oclusão da vascularização renal. O presente relato descreve o caso de um paciente com vários fatores de risco, porém sem um evento precipitante, que se apresentou com um curso clínico bastante atípico de doença ateroembólica grave de evolução espontânea e silenciosa.


Subject(s)
Humans , Male , Aged , Renal Insufficiency/diagnostic imaging , Atherosclerosis/complications , Dyslipidemias/complications , Hypertension/complications , Biopsy , Platelet Aggregation Inhibitors/therapeutic use , Hypertriglyceridemia , Aspirin/therapeutic use , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Creatinine/blood , Diabetes Mellitus, Type 2/complications , Diabetic Nephropathies/etiology , Renal Insufficiency/etiology , /therapeutic use , Hypercholesterolemia , Kidney/pathology , Microscopy , Anti-Inflammatory Agents/therapeutic use
19.
Rev. chil. nutr ; 46(1): 32-38, feb. 2019. tab
Article in English | LILACS | ID: biblio-985391

ABSTRACT

ABSTRACT There is a high prevalence of dyslipidemia in adolescence. The aim of this study was to determine the lipid profile of adolescents and associated factors. We conducted a cross-sectional study with male and female adolescents from public and private schools in Teresina, aged 14 to 19 years. Body mass index (BMI) z-score was obtained and adjusted for age, in addition to waist circumference (WC) percentile values. Lipid profile was determined by enzymatic colorimetric method; LDL-C was calculated. The statistical tests Mann-Whitney U, Student's t, and odds ratio were used. The sample was comprised of 327 adolescents with a mean age of 16.5 years, 59.6% were female and 65.7% from public schools. The prevalence of dyslipidemia was 85.6%, especially hypoalphalipoproteinemia. TG levels were significantly higher and HDL levels were lower among participants who attended public schools (P< 0.05). BMI and WC were associated with dyslipidemia; a higher mean BMI and overweight was observed in girls with dyslipidemia. In the adjusted regression, being from a public school increased the odds for low HDL-C and dyslipidemia, while overall higher BMI and abdominal excess weight represented a risk for higher triglycerides. Thus, overweight increased the chances of hypertriglyceridemia and studying in a public school increased the odds for dyslipidemia and hypoalphalipoproteinemia.


RESUMEN Las dislipidemias tienen una elevada prevalencia en la adolescencia. Nuestro objetivo fue determinar el perfil lipídico de adolescentes y sus factores asociados. Realizamos un estudio transversal que abarcó adolescentes de escuelas públicas y privadas de Teresina, con edad entre 14 y 19 años, de los dos sexos. El índice de masa corporal (escore-z, IMC-Z) se obtuvo conforme a la edad, y la circunferencia de la cintura (CC) en percentil. La determinación del perfil lipídico se realizó por método enzimático colorimétrico; LDL-C fue calculado. Las pruebas estadísticas Mann-Whitney U, T de Student y odds ratio fueran utilizadas. La muestra comprendió 327 adolescentes con edad media de 16,5 años, siendo 59,6% del sexo femenino y el 65,7% de escuelas públicas. La prevalencia de dislipidemia fue 85,6%, destacándose la hipo-alfa-lipoproteinemia. Los niveles de TC fueron significativamente mayores y los de HDL menores en las escuelas públicas (P< 0,05). Al asociar IMC y CC con dislipidemia, se observó mayores valores medios de IMC en las niñas con dislipidemia y sobrepeso. En la regresión ajustada, ser de escuela pública aumentó las posibilidades de bajo HDL-C y dislipidemia, mientras que el exceso de peso global y abdominal fueron factores de riesgo de cambios en los triglicéridos. Así, el exceso de peso elevó las posibilidades de hipertrigliceridemia, y estudiar en escuela pública elevó las posibilidades de dislipidemia e hipo-alfa-lipoproteinemia.


Subject(s)
Humans , Hypertriglyceridemia , Adolescent , Dyslipidemias , Obesity, Abdominal , Obesity , Nutritional Status
20.
Article in English | WPRIM | ID: wpr-764990

ABSTRACT

BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences exist. METHODS: This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. RESULTS: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P < 0.001); however, symptomatic GERD showed predominance in women (6.2% vs. 2.5%, P < 0.001). Although the prevalence of RE gradually increased with the duration of menopause stratified by decade (P = 0.007), that of symptomatic GERD rapidly increased across the menopausal transit in women. Apart from common risk factors of obesity and current smoking for RE, over 70 years of age in women and hiatal hernia and hypertriglyceridemia in men were significant risk factors. In symptomatic GERD, high somatization was a common risk factor. Excessive alcohol drinking was a significant risk factor in men, but not in women. CONCLUSION: This study showed a predominance of RE in men, but a predominance of symptomatic GERD in women. In women, dynamic increase in the prevalence of GERD is closely related to the menopause conditions and its duration. There are specific risk factors for RE and symptomatic GERD according to gender differences.


Subject(s)
Alcohol Drinking , Cohort Studies , Esophagitis, Peptic , Female , Gastroesophageal Reflux , Hernia, Hiatal , Humans , Hypertriglyceridemia , Life Style , Male , Mass Screening , Menopause , Obesity , Prevalence , Risk Factors , Smoke , Smoking
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