Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 11 de 11
Filter
1.
An. bras. dermatol ; 92(1): 104-106, Jan.-Feb. 2017. graf
Article in English | LILACS | ID: biblio-838022

ABSTRACT

Abstract: Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism. The association of psoriasis with hyperuricemia can trigger the onset of gouty arthritis, and pose a greater risk of developing other inflammatory comorbidities. Therefore, it is important to periodically investigate uric acid levels in order to treat changes triggered by hyperuricemia.


Subject(s)
Humans , Male , Middle Aged , Psoriasis/complications , Hyperuricemia/etiology , Gout/etiology , Chronic Disease , Gout/pathology
2.
Rev. bras. reumatol ; 56(6): 471-477, Nov.-Dec. 2016. tab
Article in English | LILACS | ID: biblio-830079

ABSTRACT

ABSTRACT Objectives: To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. Methods: This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was completed for all the participants and the medical records were reviewed regarding the occurrence of arterial or venous thrombotic events, stroke, seizure, depression, headache, psychosis, and peripheral neuropathy. In addition blood samples were drawn to obtain serum uric acid, triglyceride (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and total cholesterol levels. Results: Hyperuricemia (serum uric acid ≥6 mg/dl for women and ≥7 mg/dl for men) was detected in 16.1% of SLE patients and was significantly associated with the occurrence of stroke (OR, 2.38; 95%CI, 1.2-7.24), and peripheral neuropathy (OR, 3.49; 95% CI, 1.52-12.23), independent of hypertension and hyperlipidemia. Hyperuricemia was also significantly associated with hypertension (OR, 7.76; 95% CI, 2.72-15.76), hyperlipidemia (OR, 5.05; 95% CI, 1.59-11.32), and history of arterial thrombosis (OR, 4.95; 95% CI, 1.98-15.34), independent of age and body mass index. Conclusions: Hyperuricemia in SLE patients is independently associated with the occurrence of stroke and peripheral neuropathy. It is also independently associated with hypertension, hyperlipidemia, and history of arterial thrombosis, which are the major stroke and myocardial infarction risk factors in SLE patients.


RESUMO Objetivos: Avaliar a associação entre a hiperuricemia e diferentes manifestações neuropsiquiátricas e os fatores de risco para AVE em pacientes com lúpus eritematoso sistêmico (LES). Métodos: Este estudo foi feito em 204 pacientes com LES que foram internados em um centro de referência de atenção terciária. Todos os participantes preencheram um questionário padronizado e os prontuários médicos foram analisados quanto à ocorrência de eventos trombóticos arteriais ou venosos, acidente vascular encefálico, convulsão, depressão, cefaleia, psicose e neuropatia periférica. Além disso, foram coletadas amostras de sangue para se mensurarem os níveis de ácido úrico, triglicerídeos (TG), lipoproteínas de alta densidade (HDL), lipoproteínas de baixa densidade (LDL) e colesterol total do sangue. Resultados: A hiperuricemia (ácido úrico sérico ≥ 6 mg/dL para mulheres e ≥ 7 mg/dL para homens) foi detectada em 16,1% dos pacientes com LES e esteve significativamente associada à ocorrência de AVE (OR, 2,38; IC 95%, 1,2-7,24) e neuropatia periférica (OR, 3,49; IC 95%, 1,52-12,23), independentemente da hipertensão arterial e da hiperlipidemia. A hiperuricemia também esteve significativamente associada à hipertensão arterial (OR, 7,76; IC 95%, 2,72-15,76), hiperlipidemia (OR, 5,05; IC 95%, 1,59-11,32) e história de trombose arterial (OR, 4,95; 95% CI, 1,98-15,34), independentemente da idade e do índice de massa corporal. Conclusões: A hiperuricemia em pacientes com LES está independentemente associada à ocorrência de acidente vascular encefálico e neuropatia periférica. Também está independentemente associada à hipertensão, hiperlipidemia e história de trombose arterial, que são os principais fatores de risco para acidente vascular encefálico e infarto agudo do miocárdio em pacientes com LES.


Subject(s)
Humans , Male , Female , Uric Acid/blood , Cholesterol/blood , Hyperuricemia/etiology , Hyperuricemia/psychology , Lupus Erythematosus, Systemic/complications , Risk Factors , Peripheral Nervous System Diseases/etiology , Peripheral Nervous System Diseases/epidemiology , Stroke/etiology , Stroke/epidemiology , Cholesterol, HDL/blood
3.
Indian J Cancer ; 2014 Apr-Jun; 51(2): 180-183
Article in English | IMSEAR | ID: sea-154333

ABSTRACT

BACKGROUND: Patients with hematological malignancies that are highly proliferative and have high tumor burden are at high risk of developing hyperuricemia and tumor lysis syndrome (TLS), spontaneously and while undergoing chemotherapy. AIM: To assess the safety and efficacy of a new generic formulation of recombinant rasburicase in prevention and treatment of malignancy‑associated hyperuricemia. MATERIALS AND METHODS: An open‑label, multicenter, phase‑III study was conducted on 100 eligible patients with high risk for TLS. Rasburicase was administered 0.2 mg/kg intravenously over 30 min, daily, for 4 days. The outcome measures were percentage of reduction in plasma uric acid at 4 h after rasburicase, plasma uric acid area under the curve (AUC)0-96 h and incidence of adverse events. RESULTS: Eighty eight patients completed the study period of 10 days. After rasburicase administration, there was a 75.3 ± 28.5% of reduction in plasma uric acid at 4 h as compared to baseline. The plasma uric acid AUC0-96 h was 259.9 ± 215.5 mg/dL h. Safety of rasburicase was assessed on the basis of changes in vitals, hematological, and biochemical parameters from baseline to termination. Except for the plasma uric acid level, there was no significant difference in any of the parameters. Mild to moderate adverse events were reported in 29 patients. Three patients had serious adverse events (SAEs) unrelated to rasburicase. CONCLUSIONS: These results demonstrated that recombinant rasburicase that is indigenously developed is effective for prevention and management of hyperuricemia in patients who are at high risk of developing TLS.


Subject(s)
Adult , Aged , Area Under Curve , Child , Female , Gout Suppressants/therapeutic use , Hematologic Neoplasms/complications , Humans , Hyperuricemia/drug therapy , Hyperuricemia/etiology , India , Male , Middle Aged , ROC Curve , Tumor Lysis Syndrome/prevention & control , Urate Oxidase/therapeutic use , Uric Acid/blood , Young Adult
4.
J. pediatr. (Rio J.) ; 89(4): 412-418, ju.-ago. 2013. tab
Article in Portuguese | LILACS | ID: lil-684142

ABSTRACT

OBJETIVO: Verificar a relação entre a concentração de ácido úrico sérico de acordo com a presença ou não de esteatose hepática não alcoólica e/ou síndrome metabólica (SM) em crianças e adolescentes com sobrepeso ou obesidade. MÉTODOS: Estudo transversal desenvolvido no período de abril/2009 a março/2010, incluindo 129 crianças e adolescentes atendidos no Centro de Obesidade Infantil. Foi realizada antropometria, aferição da pressão arterial, dosagem dos exames laboratoriais e o diagnóstico de esteatose hepática por exame ultrassonográfico. Para o diagnóstico de SM, foram utilizados os critérios da National Cholesterol Education Program/Adult Treatment Panel III adaptados para faixa etária. Para avaliação da associação do ácido úrico com os grupos, foi realizado o teste do Qui-quadrado ou Fisher, adotando-se o intervalo de confiança de 95%. Para comparação de médias, utilizou-se o ANOVA One Way. Para o ajuste das variáveis foi utilizada a regressão logística múltipla. Os dados foram processados no SPSS versão 17. RESULTADOS: Níveis elevados de ácido úrico associaram-se significativamente à adolescência, SM e pressão arterial sistólica. O maior quartil de ácido úrico apresentou valores médios significativamente mais elevados de índice de massa corpórea, circunferência abdominal, pressão arterial sistólica, pressão arterial diastólica, triglicerídeos, colesterol total e HOMA-IR, e menor média do colesterol HDL. No modelo final só permaneceram associadas aos níveis de ácido úrico a faixa etária e a presença de síndrome metabólica. CONCLUSÕES: Níveis elevados de ácido úrico estiveram associados à síndrome metabólica e à adolescência, o que não foi observado com a esteatose hepática.


OBJECTIVE: To investigate the association between serum uric acid concentration according to the presence or absence of non-alcoholic fatty liver disease (NAFLD) and/or metabolic syndrome (MS) in overweight or obese children and adolescents. METHODS: This was a cross-sectional study conducted from April of 2009 to March of 2010, including 129 children and adolescents treated at the Center for Childhood Obesity. Anthropometric data, blood pressure measurements, and laboratory test results were obtained, and NAFLD diagnosis was made by ultrasound. The diagnosis of MS was made using the criteria of the National Cholesterol Education Program/Adult Treatment Panel III, adapted to age range. The chi-squared test or or Fisher's test were used to evaluate the association of uric acid with the groups, with a 95% confidence interval. One way analysis of variance (ANOVA) was used for comparison of means. Multiple logistic regression was used for adjustment of variables. The data were analyzed with the Statistical Package for Social Sciences (SPSS), release 17. RESULTS: High levels of uric acid were significantly associated with adolescence, MS, and systolic blood pressure. The highest quartile of uric acid showed significantly higher values of body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, and homeostatic model assessment index (HOMA-IR), and lower mean values of HDL cholesterol. In the final model, only age range and the presence of MS remained associated with uric acid levels. CONCLUSIONS: High levels of uric acid were associated with MS and adolescence, which was not observed with NAFLD.


Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Male , Fatty Liver/blood , Metabolic Syndrome/blood , Metabolic Syndrome/complications , Overweight/complications , Uric Acid/blood , Body Mass Index , Blood Pressure/physiology , Brazil/epidemiology , Fatty Liver/complications , Fatty Liver/epidemiology , Hyperuricemia/etiology , Metabolic Syndrome/epidemiology , Obesity/complications , Obesity/epidemiology , Overweight/blood , Overweight/epidemiology , Prevalence , Risk Factors
5.
Article in English | WPRIM | ID: wpr-159655

ABSTRACT

There have been many studies between serum uric acid (UA) and chronic kidney disease (CKD). However, as far as we know, little research has been done to examine the prospective association between serum UA and development of CKD in Korean men. This prospective cohort study was performed using 18,778 men who participated in a health checkup program both on January, 2005 and on December, 2009. CKD was defined as an estimated glomerular filtration rate or = 7.0 mg/dL) to those with normouricemia ( < 7.0 mg/dL) was 1.96 (1.28-2.99). Elevated serum UA levels were independently associated with increased likelihood for the development of CKD in Korean men (IRB number: KBC10034).


Subject(s)
Adult , Age Factors , Alcohol Drinking , Asians , Blood Pressure , Body Mass Index , Cohort Studies , Follow-Up Studies , Glomerular Filtration Rate , Humans , Hyperuricemia/etiology , Insulin Resistance , Logistic Models , Male , Middle Aged , Odds Ratio , Prospective Studies , Renal Insufficiency, Chronic/blood , Republic of Korea , Smoking , Triglycerides/blood , Uric Acid/blood
6.
Article in English | IMSEAR | ID: sea-143636

ABSTRACT

Glycogen storage diseases (GSD) are inherited autosomal recessive disorder.Type-IGSD(Von Gierkes disease) is due to glucose- 6-phosphatase defect, which mainly affects liver and is life threatening if not treated. The main features are fasting hypoglycemia, lactic acidosis, hyperuricemia and hyperlipidemia. Here we present a case of six month female baby who presented with fever, abdominal distension and on investigation biochemical parameters were suggestive of type-I GSD.


Subject(s)
Glucose-6-Phosphatase , Glycogen Storage Disease Type I/diagnosis , Humans , Hypoglycemia/etiology , Hyperlipidemias/etiology , Hyperuricemia/etiology
7.
Arq. bras. cardiol ; 98(1): 13-21, jan. 2012. graf, tab
Article in Portuguese | LILACS | ID: lil-613414

ABSTRACT

FUNDAMENTO: Não há dados relativos à epidemiologia da hiperuricemia em estudos brasileiros de base populacional. OBJETIVO: Investigar a distribuição de ácido úrico sérico e sua relação com variáveis demográficas e cardiovasculares. MÉTODOS: Estudamos 1.346 indivíduos. A hiperuricemia foi definida como > 6,8 e > 5,4 mg/dL para homens e mulheres, respectivamente. A síndrome metabólica (SM) foi definida utilizando-se os critérios NCEP ATP III. RESULTADOS: A prevalência de hiperuricemia foi de 13,2 por cento. A associação de ácido úrico sérico (AUS) com fatores de risco cardiovasculares foi específica para o gênero: em mulheres, maiores níveis de AUS estiveram associados com IMC elevado, mesmo após ajustes da pressão arterial sistólica para idade (PAS). Em homens, a relação do AUS com o colesterol HDL esteve mediada pelo IMC, enquanto em mulheres, o AUS mostrou-se semelhante e dependente do IMC, independentemente dos níveis glicose e presença de hipertensão. Nos homens, os triglicerídeos, a circunferência abdominal (CA) e a PAS explicaram 11 por cento, 4 por cento e 1 por cento da variabilidade do AUS, respectivamente. Nas mulheres, a circunferência abdominal e os triglicerídeos explicaram 9 por cento e 1 por cento da variabilidade de AUS, respectivamente. Em comparação com o primeiro quartil, homens e mulheres no quarto quartil apresentavam 3,29 e 4,18 vezes mais de aumento de risco de SM, respectivamente. As mulheres apresentaram uma prevalência quase três vezes maior de diabetes melito. Homens normotensos com MS apresentaram maiores níveis de AUS, independente do IMC. CONCLUSÃO: Nossos resultados parecem justificar a necessidade de uma avaliação baseada no gênero em relação à associação do AUS com fatores de risco cardiovasculares, que se mostraram mais acentuados em mulheres. A SM esteve positivamente associada com AUS elevado, independentemente do gênero. A obesidade abdominal e a hipertrigliceridemia foram os principais fatores associados com a hiperuricemia mesmo em indivíduos normotensos, o que pode adicionar maior risco para a hipertensão.


BACKGROUND: There is no data concerning the epidemiology of hyperuricemia in Brazilian population-based studies. OBJECTIVE: To investigate the distribution of serum uric acid and its relationship with demographics and cardiovascular variables. MEHTODS: We studied 1,346 individuals. Hyperuricemia was defined as > 6.8 and > 5.4 mg/dL for men and women, respectively. Metabolic syndrome (MS) was defined with NCEP ATP III criteria. RESULTS: The prevalence of hyperuricemia was 13.2 percent. The association of serum uric acid (SUA) with cardiovascular risk factors was gender-specific: in women, higher SUA was associated with increasing BMI, even after adjustments for age-systolic blood pressure (SBP). In men, the relationship of SUA with HDLc was mediated by BMI, whereas in women, SUA was similar and dependent on BMI, regardless of glucose levels and presence of hypertension. In men, triglycerides, waist circumference (WC) and SBP explained 11 percent, 4 percent and 1 percent of SUA variability, respectively. In women, WC and triglycerides explained 9 percent and 1 percent of SUA variability, respectively. Compared to the first quartile, men and women in the fourth quartile had a 3.29 fold and 4.18 fold increase of MS risk, respectively. Women had almost three fold higher prevalence of diabetes mellitus. Normotensive men with MS presented higher SUA, regardless of BMI. CONCLUSION: Our results seem to justify the need for gender-based evaluation regarding the association of SUA with cardiovascular risk factors, which was more pronounced in women. MS was positively associated with increasing SUA, regardless of gender. Abdominal obesity and hypertriglyceridemia were the main factors associated with hyperuricemia even in normotensive individuals, which may add a higher risk for hypertension.


RFUNDAMENTO: No existen datos relativos a la epidemiología de la hiperuricemia en los estudios brasileros de base poblacional. OBJETIVO: Investigar la distribución del ácido úrico sérico y su relación con las variables demográficas y cardiovasculares. MÉTODOS: Estudiamos 1.346 individuos. La hiperuricemia se definió como > 6,8 y > 5,4 mg/dL para hombres y mujeres, respectivamente. El síndrome metabólico (SM) fue definido utilizando los criterios NCEP ATP III. RESULTADOS: La prevalencia de hiperuricemia fue de un 13,2 por ciento. La asociación del ácido úrico sérico (AUS), con los factores de riesgo cardiovasculares fue específica para el género: en las mujeres, mayores niveles de AUS estuvieron asociados con un IMC elevado, incluso después de los ajustes para la presión arterial sistólica (PAS) y edad . En los hombres, la relación del AUS con el colesterol HDL fue mediada por el IMC, mientras que en las mujeres, el AUS demostró ser parecido y dependiente del IMC, independientemente de los niveles de glucosa y de la presencia de hipertensión. En los hombres, los triglicéridos, la circunferencia abdominal (CA) y la PAS, explicaron el 11 por ciento, 4 por ciento y el 1 por ciento de la variabilidad del AUS, respectivamente. En las mujeres, la circunferencia abdominal y los triglicéridos explicaron el 9 por ciento y el 1 por ciento de la variabilidad de AUS, respectivamente. En comparación con el primer cuartil, los hombres y las mujeres, en el cuarto cuartil, tenían 3,29 y 4,18 veces más aumento de riesgo de SM, respectivamente. Las mujeres tenían una prevalencia casi tres veces mayor de diabetes mellitus. Los hombres normotensos con MS tenían mayores niveles de AUS, independiente del IMC. CONCLUSIONES: Nuestros resultados parecen justificar la necesidad de una evaluación con base en el género, respecto de la asociación del AUS con los factores de riesgo cardiovasculares, que demostraron ser más acentuados en las mujeres. La SM estuvo positivamente asociada con el AUS elevado, independientemente del género. La obesidad abdominal y la hipertrigliceridemia fueron los principales factores asociados con la hiperuricemia incluso en los individuos normotensos, lo que puede añadirle un riesgo mayor a la hipertensión.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Hypertension/diagnosis , Hypertriglyceridemia/complications , Hyperuricemia/epidemiology , Obesity, Abdominal/complications , Uric Acid/blood , Body Mass Index , Biomarkers/blood , Brazil/epidemiology , Epidemiologic Methods , Hypertension/epidemiology , Hypertension/etiology , Hyperuricemia/etiology , Metabolic Syndrome/epidemiology , Reference Values , Sex Distribution , Sex Factors
8.
Rev. chil. pediatr ; 82(4): 344-350, ago. 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-608838

ABSTRACT

Tumor lysis syndrome is a metabolic emergency resulting from the rapid and massive destruction of tumor cells, spontaneously or secondary to cytolytic therapy for cancer. This results in a huge imbalance of internal environment by releasing large amounts of intracellular contents into the interstitial and intravascular space, with serious clinical consequences or even death. The pediatric population is especially at risk of tumor lysis syndrome because it has a high rate of fast-growing tumors, such as those of hematologic origin. Proper recognition of the risk factors that can cause this syndrome, as well as specific prevention and treatment has substantially decreased complications and improved survival in these patients.


El síndrome de lisis tumoral es una emergencia metabólica derivada de la rápida y masiva destrucción de células tumorales en forma espontánea o secundaria a terapia citolítica del cáncer. Esta situación produce un enorme desequilibrio del medio interno al liberarse grandes cantidades de contenido intracelular al espacio intersticial e intravascular, con consecuencias clínicas serias e incluso mortales. La población pediátrica está especialmente expuesta a sufrir síndrome de lisis tumoral ya que presenta una tasa elevada de tumores de rápido crecimiento, como son los de orígenes hematológicos. El adecuado reconocimiento de los factores de riesgo que pueden causar este síndrome, así como su prevención y tratamiento específicos han disminuido sustancialmente las complicaciones y mejorado la sobrevida de estos pacientes.


Subject(s)
Humans , Child , Tumor Lysis Syndrome/physiopathology , Tumor Lysis Syndrome/therapy , Allopurinol/therapeutic use , Hyperuricemia/etiology , Hyperuricemia/drug therapy , Renal Insufficiency, Chronic/physiopathology , Renal Replacement Therapy , Risk Factors , Tumor Lysis Syndrome/prevention & control , Tumor Lysis Syndrome/drug therapy , Urate Oxidase/therapeutic use
9.
International Journal of Occupational and Environmental Medicine. 2010; 1 (4): 182-190
in English | IMEMR | ID: emr-117835

ABSTRACT

The presence of hyperuricemia and renal function impairment, especially in the absence of urate stone formation is strongly suggestive of lead nephropathy. The evaluation of this association is essential in areas where lead exposure is still prevalent and uncontrolled. To determine the relationship between serum uric acid and renal function indices in lead-exposed workers. A cross-sectional study of 190 adults with occupational lead exposure and 80 adults [comparison group], matched for age and sex was performed in Port Harcourt, South-south Nigeria. Blood lead was used as the biomarker of lead exposure while serum urea, serum creatinine, urine albumin [using urine albumin:creatinine ratio], estimated glomerular filtration rate [GFR] and serum uric acid were the renal function indices measured. Occupationally lead-exposed subjects had a significantly [p = 0.008] higher mean_SD blood lead levels [50.37 +/- 24.58 M9/dL] than the comparison group [41.40 +/- 26.85]. The mean_SD serum urea [8.6 +/- 2.3 mg/dL], creatinine [1.0 +/- 0.2 mg/dL] and serum uric acid [4.6 +/- 1.2 mg/dL] were significantly [p < 0.01] higher in the study subjects than the comparison group [7.6 +/- 2.4, 0.9 +/- 0.2, and 3.9 +/- 1.1 mg/dL, respectively]. The mean +/- SD creatinine clearance was significantly [p = 0.002] lower in the study subjects than the comparison group [98.9 +/- 21.3 vs. 108.2 +/- 25.2 mL/min/1.72 m[2]]. Serum uric acid level correlated positively with serum creatinine [r = 0.134] and negatively with GFR [r = 0.151]. People with occupational lead exposure are at risk of developing hyperuricemia and renal impairment


Subject(s)
Humans , Male , Female , Adult , Adolescent , Middle Aged , Lead Poisoning/blood , Occupational Exposure/adverse effects , Uric Acid/blood , Kidney Function Tests , Renal Insufficiency/etiology , Cross-Sectional Studies , Hyperuricemia/etiology
10.
Rev. bras. nutr. clín ; 24(1): 29-32, jan.-mar. 2009.
Article in Portuguese | LILACS | ID: lil-600427

ABSTRACT

Gota é uma desordem metabólica associada a alterações no metabolismo do ácido úrico e hiperuricemia. A incidência de hiperuricemia e de gota tem aumentado no mundo todo e está frequentemente associada aos fatores de risco da síndrome metabólica. A terapia nutricional consiste no consumo de alimentos pobres em purina, proteína de origem animal e frutos do mar; aumento no consumo de frutas, hortaliças, leite e derivados; adequada hidratação, e restrição de bebidas alcóolicas. A presença de hiperuricemia deve permitir a oportunidade de modificar ou corrigir suas causas, por meio de uma intervenção nutricional individualizada, e deve servir como incentivo para a implementação de estratégias modificadoras de estilo de vida, incluindo a prevenção da obesidade, intolerância à glicose, hipercolesterolemia e hipertensão arterial.


La gota es un trastorno metabólico asociado con cambios en el metabolismo del ácido úrico e hiperuricemia. La incidencia de la hiperuricemia y la gota se ha incrementado en todo el mundo y se asocia frecuentemente a los factores de riesgo del síndrome metabólico. El tratamiento nutricional es el uso de alimentos bajos en purinas, proteínas de origen animal y productos del mar, el mayor consumo de frutas, verduras, productos lácteos, una hidratación adecuada, y el alcohol restricción. La presencia de hiperuricemia debe permitir la oportunidad de cambiar o corregir sus causas, a través de una intervención nutricional individualizado, y deben servir como incentivo para la implementación de estrategias para modificar el estilo de vida, incluida la prevención de la obesidad, intolerancia a la glucosa, la hipercolesterolemia y la hipertensión.


Gout is a metabolic disorder associated with changes in uric acid metabolism and hyperuricemia. The incidence of hyperuricemia and gout has increased worldwide and is frequently associated risk factors of metabolic syndrome. Nutritional therapy is the use of low-purine foods, animal protein and seafood, increased consumption of fruits, vegetables, dairy products, adequate hydration, and restricting alcohol. The presence of hyperuricemia should allow the opportunity to change or correct their causes, through an individualized nutrition intervention, and should serve as incentive for the implementation of strategies for modifying lifestyle, including the prevention of obesity, glucose intolerance, hypercholesterolemia and hypertension.


Subject(s)
Humans , Gout/diet therapy , Gout/metabolism , Hyperuricemia/diet therapy , Hyperuricemia/etiology , Hyperuricemia/metabolism , Nutrition Therapy
11.
Bol. Hosp. Viña del Mar ; 62(4): 222-229, dic. 2006. graf
Article in Spanish | LILACS | ID: lil-455720

ABSTRACT

El mieloma múltiple es una neoplasia de las células plasmáticas que ha permanecido incurable y que tiene como complicaciones la destrucción ósea, la falla renal, la hipercalcemia y la hiperuricemia. El objetivo principal del trabajo fue establecer un factor pronóstico de sobrevida de acuerdo al perfil temporal de presentación de la fractura en hueso patológico. De un total de 96 casos, se revisaron retrospectivamente 79 pacientes diagnosticados como mieloma múltiple de alta masa celular en el Hospital Dr. Gustavo Fricke, entre enero del 1996 y septiembre del 2005. Se encontró una sobrevida promedio de 25 meses y una distribución de la patología según el sexo de 1:1. Sin embargo, los hombres tuvieron la mitad de sobrevida que las mujeres. Así también se encontró que un tercio de los pacientes presentó la fractura o falta renal como debut del mieloma, teniendo una sobrevida significativamente menor.


Subject(s)
Male , Adult , Humans , Female , Middle Aged , Fractures, Bone/etiology , Fractures, Bone/pathology , Renal Insufficiency/etiology , Multiple Myeloma/complications , Multiple Myeloma/mortality , Age Distribution , Age Factors , Anemia/etiology , Chile , Epidemiology, Descriptive , Hypercalcemia/etiology , Hyperuricemia/etiology , Prognosis , Retrospective Studies , Sex Distribution , Survival Rate
SELECTION OF CITATIONS
SEARCH DETAIL