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1.
Article in Chinese | WPRIM | ID: wpr-920997

ABSTRACT

OBJECTIVE@#To compare the clinical therapeutic effect on diarrhea-predominant irritable bowel syndrome (IBS-D) of spleen deficiency and damp excess among fire needling therapy with filiform needle combined with acupoint application therapy, simple acupoint application therapy and pinaverium bromide tablets, and explore the mechanism on the improvements in IBS-D.@*METHODS@#A total of 150 patients with IBS-D of spleen deficiency and damp excess were randomized into a combined treatment group (50 cases, 14 cases dropped off), an acupoint application group (50 cases, 16 cases dropped off ) and a western medication group (50 cases, 13 cases dropped off ). In the western medication group, pinaverium bromide tablets were prescribed for oral administration, 50 mg per time, three times a day. In the acupoint application group, the herbal plaster of @*RESULTS@#Except the score for abdominal pain in the acupoint application group and the scores for abdominal pain and abdominal distention in the western medication group after 7 days of treatment, the scores for abdominal pain, abdominal distention, defecation frequency, stool form and incomplete bowel movement after 7 and 28 days of treatment were all reduced as compared with those before treatment in each group separately (@*CONCLUSION@#The combined treatment with the fire needling therapy with filiform needle and the acupoint application therapy effectively relieves the clinical symptoms, improves the quality of life and strengthens the immunity in the patients with IBS-D. The therapeutic effect of this combined regimen is better than either simple acupoint application therapy or the oral medication of pinaverium bromide. The mechanism may be related to the regulation of the levels of T lymphocyte subsets and the modulation of the expressions of 5-HT3R and 5-HT4R mRNA in colon tissue.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Diarrhea/therapy , Humans , Irritable Bowel Syndrome/therapy , Quality of Life , Spleen , Treatment Outcome
2.
Article in Chinese | WPRIM | ID: wpr-887494

ABSTRACT

OBJECTIVE@#To explore the bidirectional regulation of acupuncture based on a subgroup analysis of multicenter randomized controlled trial of acupuncture with @*METHODS@#A total of 519 patients were included in the analysis, including 137 patients with constipation type irritable bowel syndrome (IBS-C) (92 cases in the acupuncture group and 45 cases in the polyethylene glycol [PEG] group), and 382 patients with diarrhea type irritable bowel syndrome (IBS-D) (252 cases in the acupuncture group and 130 cases in the pinaverium group). The patients in the acupuncture group were given acupuncture at Baihui (GV 20), Yintang (GV 29), Tianshu (ST 25), Shangjuxu (ST 37), Zusanli (ST 36), Sanyinjiao (SP 6) and Taichong (LR 3) once every other day, 3 times a week. The patients in the PEG group received polyethylene glycol 4000 powder orally, and the pinaverium group received pinaverium bromide tablets orally. All were treated for 6 weeks. The IBS symptom severity score (IBS-SSS) was assessed at baseline, treatment period (2, 4, 6 weeks of treatment) and 12 weeks of follow-up, and the IBS quality of life (IBS-QOL) score was evaluated at the baseline period, 6 weeks of treatment and 12 weeks of follow-up.@*RESULTS@#The total IBS-SSS scores of the two groups of IBS-C patients at 2, 4, 6 weeks of treatment and follow-up of 12 weeks were lower than those in the baseline period (@*CONCLUSION@#Acupuncture with


Subject(s)
Acupuncture Points , Acupuncture Therapy , Diarrhea , Humans , Irritable Bowel Syndrome/therapy , Quality of Life , Treatment Outcome
3.
Chinese Medical Journal ; (24): 1396-1401, 2021.
Article in English | WPRIM | ID: wpr-878181

ABSTRACT

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease worldwide. Current guidelines of IBS are mostly based on the western populations and expected to vary in different communities. China has a large population and a vast literature is available on IBS. Due to linguistic variations in the literature, the studies are not widely known and their conclusions thus remain largely obscured to the western medical literature. In this article, we reviewed the published literatures on the investigations of IBS epidemiology, diagnosis, and management in the Chinese population and emphasized the different findings gleaned from the western publications. The detailed literature review will benefit understanding of and promote future study on IBS.


Subject(s)
China/epidemiology , Gastrointestinal Diseases , Humans , Irritable Bowel Syndrome/therapy
4.
Article in Chinese | WPRIM | ID: wpr-877622

ABSTRACT

OBJECTIVE@#To compare the curative effect on diarrhea-predominant irritable bowel syndrome (IBS-D) between acupuncture for regulating @*METHODS@#A total of 231 patients with IBS-D were randomized into an acupuncture group (154 cases) and a western medication group (77 cases) at the ratio of 2 to 1. In the acupuncture group, acupuncture was applied to acupoint regimen for regulating @*RESULTS@#After treatment and in follow-up, the total scores of IBS-SSS in the patients of the two groups were all reduced as compared with those before treatment (@*CONCLUSION@#Acupuncture for regulating


Subject(s)
Acupuncture Therapy , Diarrhea/therapy , Humans , Irritable Bowel Syndrome/therapy , Quality of Life , Serotonin Plasma Membrane Transport Proteins/genetics , Spleen , Treatment Outcome
6.
Evid. actual. práct. ambul ; 23(1): e002045, 2020. tab
Article in Spanish | LILACS | ID: biblio-1103172

ABSTRACT

Una mujer de 36 años, diagnosticada con síndrome de intestino irritable a predominio de diarrea (SII-D) acude a la consulta médica. Ella pregunta si el uso de probióticos sería útil para controlar los episodios de diarrea, ya que los fármacos con los que está siendo tratada no le resultan eficaces. Se realizó una búsqueda bibliográfica con el objetivo de en contrar evidencia en respuesta a su consulta, tras la cual se seleccionaron dos ensayos clínicos y una revisión sistemática. Se evidenciaron diversos resultados en cuanto al uso de probióticos en el SII-D y se discutieron los riesgos y beneficios del tratamiento, así como las implicancias en la vida de la paciente. (AU)


A 36-year-old woman diagnosed with diarrhea predominant irritable bowel syndrome (D-IBS) goes to meet the doctor. She raises whether the use of probiotics would be useful for controlling diarrhea episodes, since the drugs which she is being treated with, are not effective. A bibliographic search was conducted with the objective of finding evidence in response toher query. Two clinical trials and a systematic review were found. Variable results were found regarding the use of probioticsin D-IBS. The risks and benefits of the treatment were discussed, as well as the implications in the patient's lifestyle. (AU)


Subject(s)
Humans , Female , Adult , Probiotics/therapeutic use , Irritable Bowel Syndrome/therapy , Diarrhea/therapy , Parasympatholytics/therapeutic use , Quality of Life , Review Literature as Topic , Abdominal Pain/therapy , Cholestyramine Resin/therapeutic use , Clinical Trials as Topic , Probiotics/administration & dosage , Probiotics/adverse effects , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/etiology , Diarrhea/complications , Duration of Therapy , Gastrointestinal Motility/immunology , Intestinal Mucosa/immunology , Loperamide/therapeutic use , Antidepressive Agents/therapeutic use
8.
Brasília; Fiocruz Brasília;Instituto de Saúde de São Paulo; dez. 3, 2019. 34 p.
Non-conventional in Portuguese | ColecionaSUS, LILACS, ColecionaSUS, MTYCI, PIE | ID: biblio-1118203

ABSTRACT

O yoga caracteriza-se como uma prática integrativa de origem oriental que combina posições corporais, técnicas de respiração, meditação e relaxamento. É indicada no tratamento de sistemas musculoesquelético, endócrino, respiratório, além de outros agravos à saúde, e estimula as funções cognitivas. Qual a eficácia/efetividade e a segurança do yoga para tratamento da dor aguda ou crônica em população adulta? As buscas foram realizadas nas bases de dados Pubmed, HSE-Health Systems Evidence, Epistemonikos, Portal Regional da BVS, HE-Health Evidence e Embase, em 27 de setembro de2019. Foram incluídas revisões sistemáticas (RS), com ou sem metanálises, publicadas em inglês, espanhol e português, e que que avaliavam o yoga no tratamento de dor crônica e aguda na população adulta e/ou idosa. Não houve restrição em relação ao ano de publicação. As estratégias de busca foram utilizadas com base na combinação de palavras-chave estruturadas a partir do acrônimo PICOS, usando os termos MeSH no Pubmed e DeCS na BVS, adaptando-os ao HSE, Epistemonikos, HE e Embase. A qualidade metodológica das revisões sistemáticas selecionadas foi avaliada segundo a ferramenta Assessing the Methodological Quality of Systematic Reviews(AMSTAR 2). De 693 artigos identificados, dez revisões sistemáticas foram selecionadas, oito delas com meta-análises. Com relação à qualidade metodológica, três revisões foram consideradas de qualidade moderada, duas de baixa qualidade e cinco de qualidade criticamente baixa. Na lombalgia crônica, a prática de yoga, quando comparada a atividades passivas, cuidado habitual, educação, atendimento médico padrão, controle de atenção, lista de espera, sem exercícios físicos, mostrou ser eficaz na diminuição da dor em curto, médio e longo prazos. Os resultados são mais consistentes com relação aos efeitos em curto e médio prazos. Na comparação de yoga com exercícios físicos as evidências resultam de poucos estudos e são controversas, mostrando benefício em curto e médio prazos no controle de lombalgia ou diferenças estatisticamente não significantes. Yoga, em comparação a intervenções passivas, sem exercícios físicos, mostrou ser benéfico também para melhorar quadros de incapacidade específica relacionada à lombalgia, em curto, médio e longo prazos. Além disso, houve melhora clínica dos casos de lombalgia a favor de yoga em curto e médio prazos. Na dor cervical crônica, as revisões mostraram evidências de efeitos benéficos de yoga para redução da dor quando comparado a cuidados habituais ou exercícios, entretanto não houve diferença com pilates ou medicina complementar e alternativa Da mesma forma, yoga mostrou-se superior a cuidados habituais e exercícios na redução da incapacidade relacionada dor cervical. A qualidade de vida e o humor melhoraram com yoga em relação a cuidados habituais. Yoga parece trazer benefícios também para pessoas com quadros de dor relacionados a osteoartrite e artrite reumatoide, fibromialgia, síndromes do túnel do carpo e do intestino irritável. No entanto, os resultados são menos consistentes. Com relação à segurança da prática de yoga, as evidências mostraram eventos adversos em geral sem gravidade. E quando comparado a exercícios não houve diferença no relato de eventos adversos. As revisões sistemáticas apresentaram resultados favoráveis à prática de yoga em relação aos cuidados habituais, particularmente nos casos de dor lombar e cervical. Há menos evidências acerca da superioridade do yoga em comparação a intervenções ativas. Em outras situações estudadas, como a dor associada a fibromialgia, osteoartrite, artrite reumatoide, síndromes do túnel do carpo e do intestino irritável, as evidências são menos consistentes. É importante ressaltar que as revisões sistemáticas incluídas nesta revisão rápida foram consideradas de baixa confiança na avaliação com a ferramenta AMSTAR 2. Além disso, os resultados têm como base estudos primários com amostras pequenas, com heterogeneidade na aplicação das intervenções, e considerável risco de viés. Isso remete à necessidade de se realizar ensaios clínicos, bem como revisões sistemáticas, com melhor qualidade metodológica


Subject(s)
Humans , Adult , Middle Aged , Aged , Yoga , Acute Pain/therapy , Chronic Pain/therapy , Osteoarthritis/therapy , Arthritis, Rheumatoid/therapy , Carpal Tunnel Syndrome/therapy , Fibromyalgia/therapy , Treatment Outcome , Low Back Pain/therapy , Neck Pain/therapy , Irritable Bowel Syndrome/therapy
9.
Säo Paulo med. j ; 137(1): 82-91, Jan.-Feb. 2019. tab
Article in English | LILACS | ID: biblio-1004735

ABSTRACT

ABSTRACT BACKGROUND: Irritable bowel syndrome (IBS) is a clinical disorder associated with high socioeconomic burden. Despite its importance, management of IBS remains difficult and several interventions have been hypothesized as beneficial for this condition. This study identified and summarized all Cochrane systematic reviews (SRs) about the effects of interventions for managing IBS patients. DESIGN AND SETTING: Review of systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). METHODS: Review of Cochrane SRs addressing interventions for IBS. RESULTS: We included six SRs assessing acupuncture, bulking agents, antispasmodics, antidepressants, herbal medicines, homeopathy, hypnotherapy and psychological therapy for IBS. The certainty of evidence ranged from unknown to moderate, mainly due to imprecision in the estimates and high risk of bias from the primary studies included. There was moderate certainty of evidence that acupuncture had no important benefit regarding improvement of symptoms and quality of life, compared with sham acupuncture. There was also very low certainty of evidence that homeopathic asafoetida, used alone or in association with nux, was better than placebo regarding self-reported overall improvement. CONCLUSION: There was moderate certainty of evidence that acupuncture had no important benefit regarding improvement of symptoms and quality of life. Further well-designed and well-conducted randomized clinical trials are needed in order to reduce the uncertainties regarding the most commonly used interventions for patients with IBS.


Subject(s)
Humans , Disease Management , Irritable Bowel Syndrome/therapy , Systematic Reviews as Topic , Psychotherapy/methods , Treatment Outcome , Evidence-Based Medicine , Irritable Bowel Syndrome/psychology
11.
Govaresh. 2018; 22 (4): 224-231
in Persian | IMEMR | ID: emr-192472

ABSTRACT

Background: The aim of this study was to evaluate the psychological characteristics of negative affect, social inhibition, and ambiguity tolerance in prediction of quality of life in patients suffering from irritable bowel syndrome [IBS]


Materials and Methods: In this cross-sectional study, 62 patients suffering from IBS who were referred to the Digestion Clinic of Shadid Beheshti Hospital in Qom city were selected with available sampling method. For data gathering, quality of life questionnaire in irritable bowel syndrome [IBS QOL], D personality type scale [DS - 14], and ambiguity tolerance questionnaire were used Lin. Research data were analyzed using Pearson correlation and regression tests


Results: This study showed that psychological characteristics of negative affect, social inhibition and ambiguity tolerance are factors prediction of quality of life in IBS suffering


Conclusion: For the recovery of the quality of life in patients suffering from IBS, appropriate interventions, training, counseling, and referral to psychologist to make positive changes in the mentioned psychological factors are recommended


Subject(s)
Humans , Irritable Bowel Syndrome/therapy , Psychology , Quality of Life , Cross-Sectional Studies
12.
Rev. colomb. gastroenterol ; 30(supl.1): 43-56, oct.-dic. 2015. ilus
Article in Spanish | LILACS, BIGG | ID: lil-776326

ABSTRACT

Objetivo: diseñar una guía de práctica clínica para disminuir la variabilidad injustificada en el diagnóstico y tratamiento de los pacientes mayores de 18 años con síndrome de intestino irritable en Colombia mediante un diagnóstico orientado y unas pautas terapéuticas establecidas. Materiales y métodos: el equipo multidisciplinario que conformó el presente Grupo Desarrollador contó con apoyo de la Asociación Colombiana de Gastroenterología, el Grupo Cochrane ITS y el Instituto de Investigaciones Clínicas de la Universidad Nacional de Colombia. Se desarrollaron preguntas clínicas relevantes y se realizó la búsqueda de guías nacionales e internacionales en bases de datos especializadas. Las guías existentes fueron evaluadas en términos de calidad y aplicabilidad; ninguna de ellas cumplió el criterio de adaptación, por lo que se decidió desarrollar una guía de novo. El Grupo Cochrane realizó la búsqueda sistemática de la literatura. Las tablas de evidencia y recomendaciones fueron realizadas usando la metodología GRADE. Resultados: se desarrolló una guía de práctica clínica basada en la evidencia para el diagnóstico y tratamiento farmacológico de los pacientes mayores de 18 años con síndrome de intestino irritable en Colombia. Conclusiones: se establecieron los criterios clínicos y signos de alarma, las pruebas diagnósticas y las aproximaciones terapéuticas de acuerdo con el síntoma predominante en los pacientes con síndrome de intestino irritable en Colombia.


Objective: To design a clinical practice guideline to reduce unwarranted variation in the diagnosis and treatment of patients over 18 years old with irritable bowel syndrome in Colombia through targeted diagnosis and a treatment guidelines established. Materials and Methods: This guide was developed by a multidisciplinary team with the support of the Colombian Association of Gastroenterology, Cochrane STI Group and Clinical Research Institute of the Universidad Nacional de Colombia. Relevant clinical questions were developed and the search for national and international guidelines in databases was performed. Existing guidelines were evaluated quality and applicability. No guideline met the criteria for adaptation, so the group decided to develop the guideline de novo. Systematic literature searches were conducted by the Cochrane Group. The tables of evidence and recommendations were made based on the GRADE methodology. Results: An evidence-based Clinical Practice Guidelines for the diagnosis and treatment of irritable bowel syndrome in patients over 18 years old was developed for the Colombian context. Conclusions: the clinical criteria and warning signs, diagnostic tests and therapeutic approaches were established in accordance with the predominant symptom in patients with irritable bowel syndrome in Colombia.


Subject(s)
Humans , Adult , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/therapy
13.
Arq. gastroenterol ; 52(4): 331-338, Oct.-Dec. 2015. graf
Article in English | LILACS | ID: lil-771916

ABSTRACT

Irritable bowel syndrome is a common, chronic relapsing gastrointestinal disorder that affects 7%-22% of the population worldwide. According to Rome III Criteria, the disorder is defined by the coexistence of abdominal discomfort or pain associated with an alteration in bowel habits. Its pathophysiology is not completely understood but, in addition to some important abnormalities, the disturbed intestinal microbiota has also been described supported by several strands of evidence. The treatment of irritable bowel syndrome is based upon several therapeutic approaches but few have been successful or without adverse events and more recently the gut microbiota and the use of probiotics have emerged as a factor to be considered. Probiotics are live micro-organisms which when consumed in adequate amounts confer a health benefit to the host, such as Lactic bacteria among others. An important scientific rationale has emerged for the use of probiotics in irritable bowel syndrome, although the data regarding different species are still limited. Not all probiotics are beneficial: it is important to select the specific strain which should be supported by good evidence base. The mechanisms of action of probiotics are described and the main strains are quoted.


A síndrome do intestino irritável é uma enfermidade crônica recidivante, que afeta 7%-22% da população mundial. Segundo os denominados Critérios de Roma III, a síndrome do intestino irritável é definida pela coexistência de dor ou desconforto abdominal associados à alteração do hábito intestinal. A fisiopatologia não é completamente esclarecida mas, além algumas importantes alterações descritas, alterações na microbiota intestinal têm tambem sido relatadas, suportadas por diferentes graus de evidência. O tratamento da síndrome do intestino irritável é baseado em diversas abordagens terapêuticas, mas, poucas tem resultados efetivamente satisfatórios ou sem a ocorrência de eventos adversos. Mais recentemente, a microbiota intestinal e o uso de probióticos têm sido considerados como fatores importantes a serem considerados. Probióticos são microrganismos vivos que, quando consumidos em quantidades adequadas, contribuem para a saúde do hospedeiro, como por exemplo, Lactobacillus acidophilus, dentre outras. Importantes justificativas científicas têm sido citadas sobre o uso de probióticos na síndrome do intestino irritável, embora sejam ainda limitados dados sobre as diferentes espécies bacterianas constituintes dos probióticos. Não todos os probióticos são benéficos nesse caso: é importante selecionar as cepas específicas as quais devem ser suportadas por evidências científicas satisfatórias. Os mecanismos de ação dos probióticos são descritos e citadas as principais cepas.


Subject(s)
Humans , Gastrointestinal Microbiome , Irritable Bowel Syndrome/therapy , Probiotics/therapeutic use , Intestinal Mucosa/microbiology , Irritable Bowel Syndrome/physiopathology
14.
Ciênc. saúde coletiva ; 20(4): 1207-1216, 04/2015.
Article in English | LILACS | ID: lil-744874

ABSTRACT

The main goal of this study is to understand and analyse the perspective of dockworkers on health and labour at the Railway Dry Port of the Municipality of Uruguaiana in the State of Rio Grande do Sul (RS), Brazil. Sixteen dockworkers participated in the study under the methodological approach of qualitative research. The fieldwork was conducted through individual interviews by applying a semi-structured research script with open-ended questions. For the data analysis, the "discourse analysis" method was adopted, leading to the definition of five thematic categories of interpretation. From the perspective of dockworkers, dock work differs in both the weight of toil, which is hard and intense, and the sense of satisfaction regarding the collaborative and collective aspect of labour, emphasising the human side of labour. Several reports on work accidents and the identification of hazards that may be avoided by implementing changes in the organisation and work conditions were also noted.


O objetivo principal deste artigo é conhecer e analisar a visão dos trabalhadores da estiva sobre a saúde e o trabalho no Porto Seco Ferroviário, do Município de Uruguaiana, no Estado do Rio Grande do Sul. Participaram do estudo dezesseis estivadores sob a perspectiva metodológica da pesquisa qualitativa. O trabalho de campo ocorreu mediante a realização de entrevistas individuais, por meio da aplicação de um roteiro de pesquisa semiestruturado com perguntas abertas. Quanto à análise dos dados, foi adotada a técnica de "análise do discurso", chegando-se à definição de cinco categorias temáticas de interpretação. Constatou-se que, na perspectiva dos trabalhadores, o trabalho na estiva se distingue tanto pelo peso da labuta, árdua e intensa, quanto pelo sentido de satisfação no tocante ao aspecto colaborativo e coletivo do trabalho, enfatizando o lado humano do labor. Observaram-se ainda muitos relatos sobre acidentes de trabalho e a identificação de riscos que podem ser evitados mediante a implementação de mudanças na organização e nas condições de trabalho.


Subject(s)
Humans , Abdominal Pain/therapy , Irritable Bowel Syndrome/therapy , Manipulation, Osteopathic/methods , Abdominal Pain/etiology , Irritable Bowel Syndrome/complications
15.
Gastroenterol. latinoam ; 26(1): 9-16, ene.-mar. 2015. tab
Article in Spanish | LILACS | ID: lil-766827

ABSTRACT

Irritable bowel syndrome (IBS) is a psychosomatic disease whose prevalence has increased considerably in recent years. IBS tends to present comorbidity with other psychopathological conditions such as anxiety, phobias, hypochondria and depression, which makes the medical and psychotherapeutic treatment more complex. There is little empirical evidence on psychotherapeutic treatments to help patients cope with these symptoms. The purpose if this study is to describe the narratives of patients with IBS and explore the role that these narratives play in the establishment and persistence of the disease. Two female IBS-patients were selected and an in depth interview was conducted. The dialogue was transcribed and data were analyzed using the biographical approach. The results show that patients have high levels of alexithymia, operational thinking and difficulties in emotional expression; confirming the main features of psychosomatic personality. It is proposed to define specific psychotherapeutic approaches for each patient according to their personality inferred through their narratives, rather than a unified approved technique for all patients with this disease...


El síndrome de intestino irritable (SII) es una enfermedad psicosomática cuya prevalencia ha aumentado considerablemente en los últimos años. Tiende a presentar comorbilidad con otros cuadros psicopatológicos como la ansiedad, fobias, hipocondría y depresión, lo cual otorga mayor complejidad al tratamiento médico y psicoterapéutico. Existe escasa evidencia empírica sobre tratamientos psicoterapéuticos que ayuden a estos pacientes a lidiar con la sintomatología. El presente trabajo tuvo por objetivo describir las narrativas de pacientes que padecen SII y explorar el rol que cumplen estas narrativas en la constitución y mantenimiento de la enfermedad. Se seleccionaron dos pacientes de sexo femenino con diagnóstico médico de SII y se realizó una entrevista en profundidad. El diálogo fue transcrito a texto y los datos fueron analizados desde el enfoque biográfico. Los resultados muestran que las pacientes padecen altos niveles de alexitimia, pensamiento operatorio y dificultades en la expresión emocional; confirmando las principales características de la personalidad psicosomática. Se propone definir abordajes psicoterapéutico específicos a cada paciente de acuerdo a su personalidad inferida a través de sus narrativas, más que una técnica homologada unificada para todos los pacientes que padecen esta enfermedad...


Subject(s)
Humans , Adult , Female , Middle Aged , Affective Symptoms , Psychophysiologic Disorders , Irritable Bowel Syndrome/psychology , Psychotherapy , Irritable Bowel Syndrome/therapy
16.
Acta gastroenterol. latinoam ; 43(4): 321-34, 2013 Dec.
Article in Spanish | LILACS, BINACIS | ID: biblio-1157393

ABSTRACT

Irritable bowel syndrome is a highly prevalent condition responsible for almost one third of visits to the gastroenterologist and huge expenses for diagnosis, treatment and loss of working days. A unique pathophysiologic mechanism has not been elucidated yet and several possibilities have been proposed such as senso-perception and motor disturbances, the effect of stress and anxiety, serotonin receptor failures, activation of abnormal brain areas and pain modulation differences, among others. The absence of a biological marker has led the investigators to consider this syndrome as an exclusion diagnostic condition, once the organic diseases have been discarded The changes in gut microbiota have recently raised great interest among gastroenterologists. The study of the small intestinal bowel overgrowth syndrome, the effect of antibiotics upon the flora, the recognition of post-infectious irritable bowel syndrome and the action of probiotics, together with the effect of malabsortion of diet carbohydrates have brought some new light in our knowledge. The present update will focus on the published evidence about the subject, bearing in mind that the mechanisms elicited here are only suitable for a subgroup of patients.


Subject(s)
Irritable Bowel Syndrome , Anti-Bacterial Agents/therapeutic use , Humans , Intestine, Small/physiopathology , Intestine, Small/microbiology , Intestinal Mucosa/physiopathology , Intestinal Mucosa/microbiology , Probiotics/therapeutic use , Irritable Bowel Syndrome/physiopathology , Irritable Bowel Syndrome/microbiology , Irritable Bowel Syndrome/therapy
17.
Rev. gastroenterol. Perú ; 32(4): 387-393, oct.-dic. 2012. ilus, tab
Article in Spanish | LIPECS, LILACS, LIPECS | ID: lil-692407

ABSTRACT

El Sindrome de Intestino Irritable (SII), es un transtorno funcional muy común y causa frecuente de consulta en gastroenterología, su fisiopatología es multifactorial y se caracteriza por dolor abdominal, distensión y alteración de los hábitos defecatorios, su terapia es básicamente sintomática (loperamida, antiespasmódicos, antidepresivos,etc).Recientemente se ha incorporado al tratamiento, el uso de probióticos que podrían mejorar su sintomatología. POBLACIÓN Y MÉTODO: Ensayo Clínico doble ciego aleatorizado simple, multicentrico que incluyó pacientes con diagnóstico de SII basado en criterios de Roma III. A estos se les administró Bromuro de Pinaverio mas placebo o Bromuro de Pinaverio mas Probiótico. La intensidad de los síntomas y el efecto del tratamiento fue valorado de acuerdo a Score de Francis antes y al final del tratamiento. Los cálculos fueron hechos con el programa SPSS 12.0.IC 95% RESULTADO. Se evaluaron 51 pacientes con promedio de edad de 43 años, mayoritariamente mestizos, 75%(38) casados y 55%(28) del sexo femenino, se encontró diferencias significativas en 4 variables de comparación: Dolor abdominal, Severidad del dolor, Días de dolor, y el Score total al final del tratamiento. CONCLUSIONES Los Probióticos utilizados como suplemento son efectivos en mejorar la sintomatología del SII.


Background: Irritable bowel syndrome (IBS) is a very common functional condition and a frequent cause of consultation in gastroenterology. With a multifactorial pathophysiology IBS is characterized by abdominal pain, distension and altered bowel habits. Loperamide, antispasmodics and antidepressants are symptomatic relievers of this disorder. Recently probiotics were incorporated to therapy, and could improve the symptomatology. Methods: multicenter randomized placebo-controlled trial that included IBS patients, diagnosed with Rome III criteria. The patients were given pinaverium bromure and placebo or pinaverium bromure and probiotics for 3 weeks. The intensity of symptoms and the effect of therapy were evaluated with the Francis Score, before and after the treatment. Statistics were done with SPSS 12.0 (C.I 95%). Results: 51 patients were evaluated, with an average age of 43 years old, mostly mestizo, 75% (38) married and 55% (28) female. There were statistical differences in four variables: abdominal pain, intensity of pain, days of pain and total score at the end of therapy. Conclusions: Probiotics used as supplement are effective in improving symptomatology of IBS.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Irritable Bowel Syndrome/therapy , Probiotics/therapeutic use , Combined Modality Therapy , Double-Blind Method , Drug Administration Schedule , Follow-Up Studies , Lactobacillus acidophilus , Morpholines/therapeutic use , Parasympatholytics/therapeutic use , Prospective Studies , Severity of Illness Index , Treatment Outcome
18.
Diagn. tratamento ; 17(2)abr. 2012.
Article in Portuguese | LILACS | ID: lil-646024

ABSTRACT

Introdução: A alcachofra é uma planta utilizada na culinária e dita com diversas propriedades medicinais.Objetivo: Verificar evidências do uso da alcachofra no tratamento de doenças.Métodos: Busca sistematizada da literatura por meio eletrônico, incluindo estudos que avaliem o uso da alcachofra namedicina.Resultados: Uma revisão sistemática mostrou resultados favoráveis a alcachofra na redução do colesterol total[intervalo de confiança (IC) de 0,40 a 0,79] e do LDL-colesterol (IC de 0,34 a 0,78). Dois ensaios clínicos randomizadoschegaram à mesma conclusão. Um estudo clínico mostrou benefício do uso da alcachofra em pacientes com síndromedo intestino irritável e outro mostrou que ela pode ser útil nas dispepsias funcionais. Um ensaio clínico constatou oaumento da atividade antioxidante total em remadores submetidos ao estresse físico e suplementados com alcachofra.Em todos os estudos não há ocorrência de efeitos adversos.Conclusão: Os estudos encontrados mostram evidências de uma ação benéfica da alcachofra nas hiperliproteinemias e nadispepsia funcional. Como sua eficácia é dose-dependente, não se pode depender apenas da ingestão de alcachofra por meioda alimentação. Os dislipidêmicos e dispépticos funcionais terão que se utilizar dos extratos vendidos comercialmente.


Subject(s)
Humans , Male , Female , Adult , Antioxidants/therapeutic use , Cynara scolymus , Dyslipidemias/therapy , Dyspepsia/therapy , Irritable Bowel Syndrome/therapy
19.
Journal of Kerman University of Medical Sciences. 2012; 19 (1): 94-103
in Persian | IMEMR | ID: emr-137408

ABSTRACT

Psychological treatment and the efficacy of drug therapy are considered to be useful in quality of life and symptoms of patients with irritable bowel syndrome. The aim of this study was to examine the effects of cognitive-behavior therapy associated with drug therapy in comparison to drug therapy alone on the quality of life and symptoms of IBS patients with diarrhea predominance. This study was a randomized clinical trial on 64 IBS patients. The patients were selected according to Rome-Hi criteria, and were divided into the two groups. Bowel Symptoms Severity and Frequency Scale [BSS-FS] and Quality Of Life [QOL-IBS] were used for evaluation of patients' symptoms. The first group underwent cognitive-behavior therapy with medication therapy, and the second group only received medication. Data were analyzed using analysis of multiple covariances [MANCOVA]. The two groups showed significant difference in the QOL-IBS in post treatment and follow-up stages [P<0/05]. There were significant differences in the severity and frequency of IBS symptoms between the two groups after the study period [P < 0.05]. However, no significant difference was observed at follow-up stage between the two groups [P > 0.05]. Cognitive-behavior therapy associated with drug therapy can be useful in IBS patients with diarrhea predominance. However, stopping this treatment may lead to recurrence of the symptoms


Subject(s)
Humans , Cognitive Behavioral Therapy/methods , Irritable Bowel Syndrome/therapy , Irritable Bowel Syndrome/drug therapy , Treatment Outcome , Evaluation Studies as Topic , Quality of Life
20.
Pediatr. mod ; 47(5)set.-out. 2011.
Article in Portuguese | LILACS | ID: lil-602411

ABSTRACT

A autora atualiza, de forma prática, os conhecimentos modernos sobre duas patologias frequentes na infância, a diarreia funcional e a síndrome do intestino irritável.O trabalho revê o histórico e a sinonímia das mesmas, trata de sua etiopatogenia, aspectos clínicos e diagnóstico, diagnóstico diferencial e tratamento.No capítulo referente à terapêutica apresenta a conduta atual, tanto dietética como medicamentosa, ressaltando as controvérsias ainda existentes a respeito.


Subject(s)
Humans , Male , Female , Child , Diarrhea/diagnosis , Diarrhea/etiology , Diarrhea/therapy , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/etiology , Irritable Bowel Syndrome/therapy
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