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1.
An. bras. dermatol ; 96(6): 762-764, Nov.-Dec. 2021. graf
Article in English | LILACS | ID: biblio-1355644

ABSTRACT

Abstract Lobomycosis is a chronic granulomatous infection caused by the yeast Lacazia loboi, typically found in tropical and subtropical geographical areas. Transmission occurs through traumatic inoculation into the skin, especially in exposed areas, of men who work in contact with the soil. Lesions are restricted to the skin and subcutaneous tissue, with a keloid-like appearance in most cases. The occurrence of squamous cell carcinoma on skin lesions with a long evolution is well known; however, there are scarce reports of lobomycosis that developed into squamous cell carcinoma. The authors report a patient from the Brazilian Amazon region, with lobomycosis and carcinomatous degeneration, with an unfavorable outcome, due to late diagnosis.


Subject(s)
Humans , Male , Lacazia , Lobomycosis/pathology , Keloid/pathology , Skin/pathology , Brazil
2.
An. bras. dermatol ; 96(6): 759-761, Nov.-Dec. 2021. graf
Article in English | LILACS | ID: biblio-1355639

ABSTRACT

Abstract Histoid leprosy is a rare form of multibacillary leprosy, characterized by the presence of papules, plaques, or nodules whose appearance is keloid-like, skin colored, or erythematous. Fusiform cells are the main histopathological feature. Due to the fact that it can simulate other dermatological lesions, for example, dermatofibroma and neurofibroma, it constitutes a diagnostic challenge for clinicians and pathologists. It is a bacilliferous form of leprosy, and it plays an important role in disease transmission. A case of a patient with histoid leprosy living in the Northeast Region of Brazil is reported.


Subject(s)
Humans , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/pathology , Leprosy, Multibacillary/diagnosis , Leprosy, Multibacillary/pathology , Leprosy, Multibacillary/drug therapy , Keloid/pathology , Leprosy/pathology , Neoplasms , Skin/pathology
3.
An. bras. dermatol ; 95(3): 386-389, May-June 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130883

ABSTRACT

Abstract We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.


Subject(s)
Humans , Male , Aged , Lobomycosis/diagnosis , Lobomycosis/pathology , Keloid/diagnosis , Keloid/pathology , Leg Dermatoses/diagnosis , Leg Dermatoses/pathology , Biopsy , Dermis/microbiology , Dermis/pathology
5.
An. bras. dermatol ; 93(2): 279-281, Mar.-Apr. 2018. graf
Article in English | LILACS | ID: biblio-887199

ABSTRACT

Abstract: Lobomycosis or lacaziosis is a chronic granulomatous fungal infection caused by Lacazia loboi. Most cases are restricted to tropical regions. Transmission is believed to occur through traumatic inoculation in the skin, mainly in exposed areas. It is characterized by keloid-like nodules. There are only a few hundred cases reported. The differential diagnoses include many skin conditions, and treatment is difficult. The reported case, initially diagnosed as keloid, proved to be refractory to surgical treatment alone. It was subsequently approached with extensive surgery, cryotherapy every three months and a combination of itraconazole and clofazimine for two years. No signs of clinical and histopathological activity were detected during follow-up.


Subject(s)
Humans , Male , Adult , Ear Diseases/pathology , Ear Diseases/therapy , Lobomycosis/pathology , Lobomycosis/therapy , Keloid/pathology , Biopsy , Treatment Outcome , Clofazimine/therapeutic use , Itraconazole/therapeutic use , Cryotherapy/methods , Diagnosis, Differential , Ear Diseases/diagnosis , Lobomycosis/diagnosis , Keloid/diagnosis , Antifungal Agents/therapeutic use
6.
Clinics ; 69(8): 565-573, 8/2014. graf
Article in English | LILACS | ID: lil-718189

ABSTRACT

Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability. The current review will focus on the definition of hypertrophic scars, distinguishing them from keloids and on the various methods for treating hypertrophic scarring that have been described in the literature, including treatments with clearly proven efficiency and therapies with doubtful benefits. Numerous methods have been described for the treatment of abnormal scars, but to date, the optimal treatment method has not been established. This review will explore the differences between different types of nonsurgical management of hypertrophic scars, focusing on the indications, uses, mechanisms of action, associations and efficacies of the following therapies: silicone, pressure garments, onion extract, intralesional corticoid injections and bleomycin. .


Subject(s)
Humans , Cicatrix, Hypertrophic/therapy , Keloid/therapy , Wound Healing , Bleomycin/therapeutic use , Injections, Intralesional , Cicatrix, Hypertrophic/etiology , Cicatrix, Hypertrophic/pathology , Adrenal Cortex Hormones/therapeutic use , Silicone Gels/therapeutic use , Gravity Suits , Keloid/pathology
7.
An. bras. dermatol ; 88(6,supl.1): 75-77, Nov-Dec/2013. graf
Article in English | LILACS | ID: lil-696834

ABSTRACT

Nodular sclerosis is a rare form of presentation related to both systemic and localized forms of scleroderma. We describe the case of a patient with nodular sclerosis in order to alert the medical community to recognize this entity.


Esclerose nodular é uma forma de apresentação cutânea rara relacionada tanto com a forma sistêmica como com a forma localizada da esclerodermia. Descrevemos aqui o caso de uma paciente esta forma nodular de esclerose, no sentido de alertar a comunidade médica para o reconhecimento dessa entidade.


Subject(s)
Adult , Female , Humans , Keloid/pathology , Scleroderma, Systemic/pathology , Biopsy , Skin/pathology
8.
An. bras. dermatol ; 88(3): 387-394, jun. 2013. tab, graf
Article in English | LILACS | ID: lil-676233

ABSTRACT

While treatment of keloids and hypertrophic scars normally shows modest results, we found that treatment with bleomycin was more promising. The present study was divided into two parts. In the first part the aim was to show the results using a combination of bleomycin and triamcinolone acetonide per cm2 (BTA). In the second part the objective was to determine the response to both drugs in large keloids that were divided into 1 cm2 squares, treating each square with the dose previously used. In the first part of the study, the clinical response of 37 keloids ranging from 0.3 to 1.8 cm2 treated with BTA were followed up over a period of 1- 2 years. 0.375 IU bleomycin and 4 mg triamcinolone acetonide were injected every 3 months. In the second part of the study we reviewed the clinical response in six patients with large keloids. The monthly dose administered never exceeded 3 IU of bleomycin. The first study showed 36 keloids (97.29%) softening after the first dose. In the second study, 5 showed different responses (the response was complete in the four smaller keloids). The largest keloid needed 9 doses to achieve an improvement of 70%. In conclusion, combined treatment with 0.375 IU of bleomycin and 4mg of triamcinolone acetonide to 1 cm2 was considered to be an acceptable procedure for the treatment of keloids. The best results were obtained in keloids over 1 cm2 or when divided into 1 cm2 square areas. Larger series need to be performed in order to confirm these results..


Enquanto normalmente o tratamento de queloides e cicatrizes hipertróficas mostra resultados moderados, o tratamento com bleomicina revelou resultados mais promissores. Este estudo foi dividido em duas partes. Na primeira parte, o objetivo foi mostrar os resultados da utilização de uma combinação de bleomicina e acetonido de triancinolona por cm2 (BAT). Na segunda parte, o objetivo foi determinar a resposta aos dois medicamentos em queloides grandes, que foram divididos em quadrados de 1 cm2, tratando cada quadrado com a dose utilizada anteriormente. Na primeira parte do estudo, a resposta clínica de 37 queloides de 0,3 to 1,8 cm2 tratados com BAT foi monitorada por um período de 1 a 2 anos. Injeções de 0,375 UI de bleomicina e 4 mg de acetonido de triancinolona foram aplicadas a cada 3 meses. Na segunda parte do estudo, revisamos a resposta clínica em 6 pacientes com queloides grandes. A dose mensal administrada nunca excedeu 3 UI de bleomicina. O primeiro estudo mostrou que 36 queloides (97,29%) amoleceram após a primeira dose. No segundo estudo, 5 mostraram diferentes respostas (a resposta foi completa nos quatro queloides menores). O queloide maior necessitou de 9 doses para apresentar melhora de 70%. Concluindo, o tratamento combinado com 0,375 UI de bleomicina e 4 mg de acetonido de triancinolona por cm2foi considerado um procedimento aceitável para o tratamento de queloides. Os melhores resultados foram obtidos em queloides com mais de 1 cm2 ou divididos em áreas de 1cm2. Estudos mais amplos deveriam ser realizados, para confirmar esses resultados.


Subject(s)
Adult , Female , Humans , Male , Young Adult , Anti-Inflammatory Agents/administration & dosage , Antibiotics, Antineoplastic/administration & dosage , Bleomycin/administration & dosage , Cicatrix, Hypertrophic/drug therapy , Keloid/drug therapy , Triamcinolone Acetonide/administration & dosage , Drug Therapy, Combination , Follow-Up Studies , Injections, Intralesional , Keloid/pathology , Photography , Skin Pigmentation , Treatment Outcome
9.
Acta cir. bras ; 26(1): 25-30, jan.-fev. 2011. ilus, tab
Article in English | LILACS | ID: lil-572230

ABSTRACT

Purpose: To quantify keloid fibroblasts after irradiation with 470nm blue LED, in vitro. Methods: Fibroblasts from keloid and adjacent skin have been obtained from 6 patients. Cells have been cultivated and maintained in DMEM culture medium. In Petri dishes, they were irradiated with energy doses of 6J, 12J and 18J. After 24 h, counting was done by the average of the triplicates for each sample. Results: There were no significant differences in the number of irradiated keloid fibroblasts at the studied doses (p=0.261). In adjacent skin fibroblasts, differences were observed (p=0.025) concerning the doses of 18 J and 6 J (p=0.03). Conclusions: There was a reduction in the number of adjacent skin fibroblasts irradiated with 470nm blue LED at the energy dose of 18 J compared to the ones irradiated at the energy dose of 6 J. There were no changes in keloid fibroblasts counting at any of the doses applied, 24 h after irradiation.


Objetivo: Quantificar fibroblastos de quelóide após irradiação com LED azul de 470nm, in vitro. Métodos: Foram obtidos fibroblastos de quelóide e pele adjacente, de seis pacientes. As células foram cultivadas e mantidas em meio de cultura DMEM. Em placas de Petri, receberam irradiação com doses de energia de 6J, 12J e 18J. Após 24 horas a contagem foi feita pela média da triplicata para cada amostra. Resultados: Não houve diferença na quantidade de fibroblastos de quelóide irradiados nas doses estudadas (p=0,261). Observou-se diferença nos fibroblastos de pele adjacente (p=0,025), com relação às doses de 18 J e 6 J (p=0,03). Conclusões: Houve redução dos fibroblastos de pele adjacente irradiados com LED azul de 470 nm na dose de energia de 18 J em relação à dose de 6 J. Não houve alteração na quantidade de fibroblastos de quelóide nas doses aplicadas após 24 horas da irradiação.


Subject(s)
Adult , Female , Humans , Middle Aged , Fibroblasts/radiation effects , Keloid/pathology , Lasers, Semiconductor/therapeutic use , Cell Count , Cells, Cultured , Fibroblasts/cytology , Radiation Dosage , Skin/cytology
10.
New Egyptian Journal of Medicine [The]. 2009; 41 (4): 364-370
in English | IMEMR | ID: emr-111495

ABSTRACT

To evaluate the effect ofcolchicine local infiltration in the treatment of keloids. Prospective study. National Hepatology and Tropical Medicine Research Institute [NHTMRI]. In a clinical trial, 14 cases with keloids were treated by local infiltration ofcolchicine. The results were evaluated objectively and subjectively. Lesional biopsy was obtained before and after treatment and examined by light microscopy. Marked reduction of the size of the lesions and decrease of such complaints as itching and erythema were noted. Favorable results were obtained according to the patients in 83.4% and according to the opinion of the medical examiner in 91.7% of cases. Systemic complications of colchicine absorption, i.e. nausea, did not occur in any patient. Histopathological examination of the lesions after colchicine infiltration reveled marked reduction in the density of collagen bundles, which are widely dispersed through out the dermis. intralesional infiltration of colchicine is safe and effective treatment, of keloids


Subject(s)
Humans , Male , Female , Colchicine , Injections, Intralesional/methods , Keloid/pathology , Treatment Outcome
11.
Indian J Dermatol Venereol Leprol ; 2007 Sep-Oct; 73(5): 336-9
Article in English | IMSEAR | ID: sea-52460

ABSTRACT

Keloids are the result of excessive fibroblast proliferation and then over-abundant collagen deposition. There is no method able to guarantee absolute success in the therapeutic approach to keloids. Our case report involves a female patient with six lesions treated with a 32P-patch brachyradiotherapy. Pre-treatment and adjuvant treatment of the lesions were performed with thiomucase, 5-fluoruracil, procaine and triamcinolone. Taking into account the activity contained in each of the patches and the total radiation dose to be administered according to clinical practice, dosimetric calculations were done for each lesion. Separate silicone patches with chromic [32P]phosphate were designed for each lesion based on these calculations. Total remission was achieved in three treated lesions. The other lesions did not achieve total remission yet, but their sizes are diminishing. The differences observed in treatment outcome may be related with lesion features, adjuvant treatments and/or treatment schedule.


Subject(s)
Aged, 80 and over , Brachytherapy/methods , Cicatrix, Hypertrophic/pathology , Female , Humans , Keloid/pathology , Phosphorus Radioisotopes/therapeutic use , Radiation Dosage , Skin/pathology
12.
Acta cir. bras ; 20(3): 200-212, May-June 2005. ilus, tab, graf
Article in English | LILACS | ID: lil-414383

ABSTRACT

OBJETIVO: Investigar a integração do transplante heterólogo de quelóide na bolsa jugal do hamster (Mesocricetus auratus). MÉTODOS: A amostragem consiste de 18 hamsters machos, heterogênicos, com 10 a 14 semanas de idade. Fragmentos de quelóide foram obtidos de cicatrizes queloidianas da região mamária de paciente adulta parda. Cada hamster foi enxertado em ambas as bolsas com fragmentos de quelóide, totalizando 36 fragmentos enxertados. Os animais foram distribuídos em 6 grupos para exame dos fragmentos enxertados, com 5, 12, 21, 42, 84 e 168 dias. Uma avaliação macroscópica é realizada comparando a bolsa contendo o fragmento enxertado em cada período com a mesma bolsa no pós-operatório imediato, mediante a comparação de fotografias padronizadas. À microscopia, considera-se a presença de vasos sangüíneos no tecido conjuntivo do fragmento enxertado como critério de integração do mesmo. Outros eventos, como secreção de queratina, presença de infiltrados celulares e aspecto do epitélio e das fibras colágenas do quelóide, também são observados. RESULTADOS: A macroscopia revela intensa vascularização na bolsa até 12 dias de enxertia, e a presença constante de pigmentação castanho-escura nos fragmentos de quelóide enxertados. Na microscopia constata-se a integração dos fragmentos de quelóide pela presença de capilares sangüíneos no tecido conjuntivo. Observa-se, também, a presença de intenso infiltrado celular do tipo inflamatório até 12 dias, a permanência do epitélio do quelóide até 21 dias, e o aparecimento de melanócitos a partir de 42 dias. CONCLUSÃO: A bolsa jugal do hamster representa, a priori, modelo experimental para investigação do quelóide.


Subject(s)
Animals , Female , Humans , Male , Keloid/pathology , Connective Tissue/blood supply , Transplantation, Heterologous/pathology , Cheek/blood supply , Cheek/surgery , Disease Models, Animal , Mesocricetus , Connective Tissue/pathology , Transplantation, Heterologous/methods
13.
Rev. Inst. Med. Trop. Säo Paulo ; 42(5): 239-243, Sept.-Oct. 2000. ilus
Article in English | SES-SP, LILACS, SES-SP, SESSP-ILSLPROD, SES-SP, SESSP-ILSLACERVO, SES-SP | ID: lil-270223

ABSTRACT

In a previous study, the authors inoculated Swiss mice with Lacazia loboi (L. loboi) and succeeded in maintaining a granulomatous infiltrate and viable fungal cells up to one year and six months after inoculation. Considering the experimental work on paracoccidioidomycosis, 0.03 ml of a fungal suspension obtained from a biopsy of a Jorge Lobo's Disease patient were inoculated into both hind foot pads of 32 six week-old BALB/c mice of both sexes. The animals were sacrificed 1, 4, 7 and 10 months post inoculation. The suspension contained 1.3 x 10(6) fungi/ml and presented 38 percent viability. Seven months after inoculation, most of the animals presented profuse infiltrates consisting of isolated histiocytes, foreign body and Langhans' giant cells and a large number of fungi, most of them viable. Emergence of macroscopic lesions was observed during the 8th month. Based on fungal count, viability index before and after inoculation, presence of macroscopic lesions and histopathological findings similar to the findings in humans, the authors believe that BALB/c mice may be a good experimental model to study Jorge Lobo's Disease, mainly regarding therapeutic evaluation


Subject(s)
Animals , Male , Female , Mice , Paracoccidioides/growth & development , Blastomycosis/microbiology , Keloid/microbiology , Time Factors , Blastomycosis/pathology , Colony Count, Microbial , Cell Survival , Disease Models, Animal , Keloid/pathology , Mice, Inbred BALB C
14.
HU rev ; 25/26(3/1): 203-20, set. 1999-abr. 2000. ilus
Article in Portuguese | LILACS | ID: lil-296293
16.
Folia dermatol. peru ; 10(4): 35-9, dic. 1999.
Article in Spanish | LILACS | ID: lil-289489

ABSTRACT

Este artículo hace un resumen sobre la patogenia de los queloides a fin de acercarnos a su manejo racional. Los próximos avances en la terapia de los queloides apuntan más hacia un manejo inmunológico que la excisión o terapia intralesionar que hoy practicamos. El tiempo nos dirá si el interferón o algún agente similar harán realidad la expectativa que nuestros pacientes esperan. Los queloides constituyen todo un desafío que tienen 4 características igualmente importantes: molestia, tamaño, color y disfunción. Debemos abordar todos estos aspectos con el paciente antes de iniciar un plan terapéutico, para asegurar que el tratamiento que nosotros consideramos como óptimo, es considerado así también por el paciente. Dado que la terapia aún está lejos de ser perfecta y sin complicaciones, el paciente debe estar preparado para afrontar un tratamiento que ha de ser largo.


Subject(s)
Humans , Adrenal Cortex Hormones , Collagen , Fibroblasts , Interferons , Keloid/pathology , Keloid/surgery , Keloid/therapy , Steroids
18.
Dermatol. rev. mex ; 36(1): 35-8, ene.-feb. 1992. ilus, tab
Article in Spanish | LILACS | ID: lil-117389

ABSTRACT

El queloide es un tipo de cicatrización de interés para la medicina general y particularmente para la cirugía. Este tipo de cicatrización es un fenómeno persistente, antiestético y algunas veces incapacitante; su manejo es difícil y el resultado con frecuencia es decepcionante para el paciente. Consideramos que toda información acerca de la cicatriz queloide nos hará entender mejor esta entidad. Abordamos los aspectos generales del queloide, incluyendo su historia, factores coadyuvantes, fisiopatología, aspectos clínicos, evolución, diagnóstico diferencial, histología y tratamiento.


Subject(s)
Humans , Keloid , Keloid/pathology , Keloid/physiopathology , Keloid/therapy , Mexico , Precipitating Factors
19.
Zagazig Medical Association Journal. 1991; 4 (1): 27-43
in English | IMEMR | ID: emr-22581

ABSTRACT

The development of keloid is an unavoidable problem, so there is a need for a simple, safe and efficient procedure which serves as a reliable and standard method for treatment of keloid scars. eighteen patients with 20 lesions without or with recurrence, after trials of steroid or surgical therapy alone, underwent a combined regimen of intralesional dissection and steroid injections therapy. All cases were closed primarily except 6 who needed full thickness skin grafting. immediate postoperative complication were managed satisfactorily by conservative treatment. Follow-up preiod for 22 months showed good prognosis in all cases except in one lesion which recurred [5% per lesion and 5.6% per patient] and is still under subsequent steroid therapy up to date. We can consider the simple, safe and efficient combination of surgical and steroid therapy as the reliable, routine and standard method for treatment of keloids and their recurrence with very low rates of associated side effects


Subject(s)
Keloid/pathology , Steroids , Skin/injuries
20.
An. bras. dermatol ; 60(supl 1): 217-24, set. 1985. ilus, tab
Article in Portuguese | LILACS | ID: lil-2213

ABSTRACT

Fragmentos de tecido queloidiano foram estudados a nível de microscopia óptica e com o uso de técnicas gerais de coloraçäo, como hematoxilina-eosina e tricrômico de Gomori e de técnicas seletivas para revelar fibras do sistema elástico, tais como hematoxilina férrica e resorcina-fucsina, esta última precedida ou näo de oxidaçäo pela oxona. Vinte e seis fragmentos foram obtidos de 23 lesöes distintas. Quatro eram conseqüentes de foliculites, sete de acne, cinco de queimaduras, cinco de cirurgias e duas eram cicatrizes "espontâneas". Foi identificada em 24 fragmentos a presença de fibras oxitalânicas distribuídas difusamente e em quantidade variável por toda a área da lesäo examinada


Subject(s)
Humans , Wound Healing , Keloid/pathology , Elastic Tissue/pathology
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