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Arq. bras. med. vet. zootec. (Online) ; 72(4): 1277-1285, July-Aug. 2020. tab, ilus
Article in Portuguese | ID: biblio-1131473


Foram padronizados os graus de lesões dos sacos aéreos em perus com aerossaculite, associadas com a presença de isolados de enterobactérias nesses órgãos. Um total de 110 amostras de sacos aéreos de perus machos com aerossaculite foi coletado para o estudo. Durante o processo de abate, as amostras foram coletadas por meio de swabs e submetidas a três métodos de armazenamento (imediato, congelado ou pré-incubado após congelamento) para posterior comparação das suas eficiências de isolamento. Os gêneros da família Enterobacteriaceae foram identificados pelas séries bioquímicas EPM, MILi e citrato de Simmons. O crescimento bacteriano ocorreu em 43,64% das amostras. Neste estudo, quatro padrões de lesões de aerossaculite foram identificados de acordo com as características patológicas dos sacos aéreos. Os principais gêneros de enterobactérias identificadas foram: Escherichia coli, Citrobacter, Proteus, Edwardsiella, Morganella, Kluyvera, Salmonella e Klebsiella. Foi observado que os graus padronizados como 3 e 4 apresentaram maior variedade de gêneros bacterianos. O armazenamento imediato apresentou maior porcentagem de positividade, 41,82%, no entanto o pré-incubado após congelamento se apresentou mais eficaz em relação à quantidade de colônias.(AU)

The degrees of air sac lesions in turkeys with airsacculitis were standardized, associated with the presence of Enterobacteriaceae isolated from these organs. A total of 110 samples of air sacs from male turkeys with airsacculitis were collected and analyzed. During the slaughtering process, the sample collection was done using swabs and submitted to three storage methods (immediate, frozen, or pre incubated after freezing) for further comparison of their isolated efficiency. The bacterial genera of the family Enterobacteriaceae were identified biochemical series EPM, MILi and Simmons citrate. Bacterial growth occurred in 43.64% of samples. In this study, four patterns of aerossaculitis lesions were identified according to the pathological characteristics of air sacs. The frequencies of the Enterobacteriaceae isolated identified in the samples were: Escherichia coli, Citrobacter, Proteus, Edwardsiella, Morganell, Kluyvera, Salmonella and Klebsiella. Otherwise, it was observed that the levels already standardized as level three and four showed higher variety of genus. The immediate storage showed higher percentage of positivity at 41.82%, however, the pre incubated after freezing showed more efficiency in relation to the quantity of colonies.(AU)

Animals , Turkeys , Air Sacs/microbiology , Enterobacteriaceae/isolation & purification , Enterobacteriaceae Infections/veterinary , Proteus , Salmonella , Citrobacter , Edwardsiella , Morganella , Kluyvera , Escherichia coli , Klebsiella
Rev. Assoc. Med. Bras. (1992) ; 66(6): 824-829, June 2020. tab
Article in English | LILACS, SES-SP | ID: biblio-1136280


SUMMARY OBJECTIVE To describe the concentration of total and specific IgG antibodies anti-Streptococcus B, anti-lipopolysaccharide of Klebsiella spp, and anti-lipopolysaccharide of Pseudomonas spp in the umbilical cord of newborn(NB) twins and to analyze the association between neonatal infection and antibody concentration in the umbilical cord blood. METHODS A prospective cross-sectional study of a cohort of NB twins admitted during the period of 20 months. Patients with malformations and mothers with infection were excluded. Variables analyzed: gestational age(GA); birth weight(BW); antibody concentrations in umbilical cord blood; infection episodes. We used the paired Student t-test, Spearman correlation, and generalized estimation equation. RESULTS 57 pairs of twins were included, 4 excluded, making the sample of 110 newborns. GA=36±1.65weeks and BW=2304.8±460g(mean±SD). Antibody concentrations in twins(mean±SD): total IgG=835.71±190.73mg/dL, anti-StreptococcusB IgG=250.66±295.1 AU/mL, anti-lipopolysaccharide of Pseudomonas spp IgG=280.04±498.66 AU/mL and anti-lipopolysaccharide of Klebsiella spp IgG=504.75±933.93 AU/mL. There was a positive correlation between maternal antibody levels and those observed in newborns(p <0.005). The transplacental transfer of maternal total IgG and anti-LPS Pseudomonas IgG antibodies was significantly lower at NB GA <34 weeks(p <0.05). Five newborns were diagnosed with an infection. Infants with infection had significantly lower total IgG concentration(p <0.05). CONCLUSION This study showed a positive correlation between maternal and newborn antibodies levels. In infants younger than 34 weeks there is less transfer of total IgG and anti-LPS Pseudomonas IgG. The highest incidence of infection in the newborn group who had significantly lower total IgG serum antibodies reinforces the importance of anti-infectious protection afforded by passive immunity transferred from the mother.

RESUMO OBJETIVOS Descrever o título de anticorpos IgG total e específico anti-Streptococcus B, anti-lipopolissacarídeos(LPS) de Klebsiella e Pseudomonas no cordão umbilical em gêmeos e analisar a possível associação entre os títulos desses anticorpos e a ocorrência de infecção. MÉTODOS Estudo prospectivo transversal de uma coorte de recém-nascidos (RN) gemelares em 20 meses. Excluídos: malformação, infecção congênita ou materna. Variáveis estudadas: idade gestacional(IG); peso de nascimento(PN); título de anticorpos e episódios de infecção. Foram utilizados testes t-Student pareado, correlação de Spearman e equações de estimação generalizadas. RESULTADOS Elegíveis 59 pares de gêmeos, excluídos 4 e incluídos 55 pares (n=110RN). A IG foi 36±1,65semanas e o PN foi 2304,8±460g (média±DP). Concentrações de anticorpos dos RN(média±DP): IgG total=835,71±190,73 mg/dL, IgG anti-Streptococcus B=295,1±250,66 UA/mL, IgG anti-LPS Pseudomonas=280,04±498,66 UA/mL e IgG anti-LPS Klebsiella=504,75± 933,93UA/mL. Houve correlação positiva entre níveis de anticorpos maternos e aqueles observados nos RN (p<0,005). A transferência transplacentária de anticorpos maternos IgG total e IgG anti-LPS Pseudomonas foi significativamente menor em RN IG < 34semanas (p<0,05). Foram diagnosticados 5 RN com infecção. Os RN que apresentaram infecção tinham concentração de IgG total significativamente menor (p<0,05). CONCLUSÕES Na população estudada existe correlação entre os anticorpos maternos e os níveis de anticorpos no RN. Nos gêmeos menores que 34 semanas há menor transferência de IgG total e IgG anti-LPS Pseudomonas. Nos RN com infecção a concentração de IgG total é significativamente menor, o que demonstra a maior vulnerabilidade e risco de infecção dessa população e a importância da imunidade passiva transferida pela placenta.

Humans , Infant, Newborn , Infant , Pseudomonas Infections/blood , Streptococcal Infections/blood , Immunoglobulin G/blood , Klebsiella , Pseudomonas , Cross-Sectional Studies , Prospective Studies , Immunity, Maternally-Acquired , Infections
Article in English | WPRIM | ID: wpr-762470


Active surveillance culture (ASC) can help detect hidden reservoirs, but the routine use of ASC for extended spectrum β-lactamase-producing Enterobacteriaceae is controversial in an endemic situation. We aimed to determine the prevalence and risk factors of extended spectrum β-lactamase-producing Klebsiella pneumoniae (EBSL-Kpn) colonization among intensive care unit (ICU)-admitted patients. Prospective screening of ESBL-Kpn colonization was performed for ICU-admitted patients within 48 hours for two months. A perirectal swab sample was inoculated on MacConkey agar supplemented with 2 µg/mL ceftazidime. ESBL genotype was determined by PCR-sequencing, and clonal relatedness was evaluated by pulsed-field gel electrophoresis (PFGE). The risk factors of ESBL-Kpn colonization were evaluated. The ESBL-Kpn colonization rate among the 281 patients at ICU admission was 6.4% (18/281), and bla(CTX-M-15) was detected in all isolates. ESBL producers also showed resistance to fluoroquinolone (38.9%, 7/18). All isolates had the same ESBL genotype (bla(CTX-M-15)) and a highly clustered PFGE pattern, suggesting cross-transmission without a documented outbreak. In univariate analysis, the risk factor for ESBL-Kpn colonization over the control was the length of hospital stay (odds ratio=1.062; P=0.019). Routine use of ASC could help control endemic ESBL–Kpn for ICU patients.

Agar , Ceftazidime , Colon , Critical Care , Electrophoresis, Gel, Pulsed-Field , Enterobacteriaceae , Genotype , Humans , Intensive Care Units , Klebsiella pneumoniae , Klebsiella , Length of Stay , Mass Screening , Prevalence , Prospective Studies , Risk Factors
Article in English | WPRIM | ID: wpr-762460


BACKGROUND: Carbapenem-resistant K. pneumoniae 2297, isolated from a patient treated with tigecycline for pneumonia, developed tigecycline resistance, in contrast to carbapenem-resistant isolate 1215, which was collected four months prior to the 2297 isolate. Mechanisms underlying tigecycline resistance were elucidated for the clinical isolates. METHODS: The tigecycline minimum inhibitory concentration (MIC) was determined using the broth microdilution method, with or without phenylalanine-arginine β-naphthylamide (PABN), and whole-genome sequencing was carried out by single-molecule real-time sequencing. The expression levels of the genes acrA, oqxA, ramA, rarA, and rpoB were determined by reverse-transcription quantitative PCR. RESULTS: Both isolates presented identical antibiograms, except for tigecycline, which showed an MIC of 0.5 mg/L in 1215 and 2 mg/L in 2297. The addition of PABN to tigecycline-resistant 2297 caused a four-fold decrease in the tigecycline MIC to 0.5 mg/L, although acrA expression (encoding the AcrAB efflux pump) was upregulated by 2.5 fold and ramA expression (encoding the pump activator RamA) was upregulated by 1.4 fold. We identified a 6,096-bp fragment insertion flanking direct TATAT repeats that disrupted the romA gene located upstream of ramA in the chromosome of K. pneumoniae 2297; the insertion led the ramA gene promoter replacement resulting in stronger activation of the gene. CONCLUSIONS: The K. pneumoniae isolate developed tigecycline resistance during tigecycline treatment. It was related to the overexpression of the AcrAB resistance-nodulation-cell division efflux system due to promoter replacement.

Humans , Klebsiella pneumoniae , Klebsiella , Methods , Microbial Sensitivity Tests , Pneumonia , Polymerase Chain Reaction , Rome
Pesqui. vet. bras ; 39(10): 796-801, Oct. 2019. tab
Article in English | ID: biblio-1056903


Respiratory diseases are among the most important diseases in sheep flocks. Herein was studied the bacterial etiology of respiratory disease and the clinical signs of 99 female and male sheep breed in the states of São Paulo (SP) and Rio de Janeiro (RJ), Brazil. After physical examination of animals, tracheobronchial flushing samples were obtained. The usual bacteria and Mycoplasma spp. were searched, as well as their association with the clinical status and clinical signs of sheep with respiratory disease. The main observed signs were: tachypnea (75%), increase of rectal temperature (09.4%), mucopurulent/purulent nasal discharge (21.9%), cough (25%), dyspnea (31.2%), changes of lung sounds at auscultation (87.5%) and chest percussion (28.1%) in pneumonic sheep. Non-fermenting gram-negative bacteria and Bacillus sp. were the most isolated bacteria. Microorganisms of the Mollicutes class were molecularly (PCR) detected in 33.3% of the animals. In addition, the specific detection of M. mycoides subsp. capri was described for the first time in sheep from the state of São Paulo, Brazil.(AU)

A doença respiratória é uma das doenças mais importantes em rebanhos ovinos. Esta pesquisa teve como objetivo determinar a etiologia bacteriana da doença respiratória e sua relação com sinais clínicos em ovinos criados nos estados de São Paulo e Rio de Janeiro, Brasil. Noventa e nove ovelhas machos e fêmeas dos Estados de São Paulo (SP) e Rio de Janeiro (RJ) foram estudadas. Após o exame físico, amostras de lavagem traqueobrônquica foram obtidas. A presença de bactérias aeróbias e Mycoplasmaspp. foram estudados, assim como a associação entre os microrganismos e estado clínico e sinais clínicos de doença respiratória em ovinos. As principais manifestações clínicas observadas foram: taquipneia (75%), alta temperatura retal (09,4%), secreção nasal mucopurulenta/purulenta (21,9%), tosse (25%), dispneia (31,2%), sons pulmonares alterados na ausculta (87,5%) e na percussão torácica (28,1%) em ovelhas pneumônicas. Bactérias gram-negativas não fermentadoras e Bacillus sp. foram as bactérias mais isoladas. Microrganismos da classe Mollicutes foram detectados molecularmente (PCR) em 33,3% dos ovinos. Além disso, descreve-se pela primeira vez no estado de São Paulo, Brasil, a detecção do M. mycoides subsp. capri na espécie ovina utilizando a reação de polimerase em cadeia.(AU)

Animals , Pasteurella Infections/veterinary , Pneumonia/etiology , Pneumonia/veterinary , Sheep , Mycoplasma Infections/veterinary , Sheep Diseases/microbiology , Bacillus/isolation & purification , Pasteurella/isolation & purification , Klebsiella/isolation & purification , Mycoplasma/isolation & purification
Article in Korean | WPRIM | ID: wpr-770028


Klebsiella pneumoniae causes that liver abscess mostly, also spread to pneumonia, meningitis, urinary tract infections. Septic arthritis caused by K. pneumoniae is a quite rare and has not been reported in Korea. Therefore, the authors report a case of the septic arthritis in the knee joint caused by K. pneumoniae in a patient with type 2 diabetes mellitus and osteoarthritis of the knee that successfully treated by early detection and arthroscopic synovectomy.

Arthritis , Arthritis, Infectious , Diabetes Mellitus, Type 2 , Humans , Klebsiella pneumoniae , Klebsiella , Knee Joint , Knee , Korea , Liver Abscess , Meningitis , Osteoarthritis , Pneumonia , Urinary Tract Infections
Article in English | WPRIM | ID: wpr-764945


BACKGROUND: This study aimed to identify the predictors and build a prediction score for community-onset bloodstream infections (CO-BSIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella species. METHODS: All CO-BSIs caused by E. coli and Klebsiella species from 2012 to 2015 were grouped into derivation (BSIs from 2012 to 2014) and validation (BSIs in 2015) cohorts. A prediction score was built using the coefficients of the multivariate logistic regression model from the derivation cohort. RESULTS: The study included 886 CO-BSIs (594 and 292 in the derivation and validation cohorts, respectively). The independent predictors of CO-BSIs caused by ESBL-producing E. coli and Klebsiella species included: 1) identification of ESBL-producing microorganisms from any clinical culture within one year of admission, 2) beta-lactam or fluoroquinolone treatment within 30 days (with 2 or more courses within 90 days; with 1 course within 90 days), 3) hospitalization within one year, 4) the presence of an indwelling urinary catheter at the time of admission. The area under the curve (AUC) of the clinical prediction score was 0.72 (95% confidence interval [CI], 0.68–0.77). In the validation cohort, the AUC was 0.70 (95% CI, 0.63–0.77). CONCLUSIONS: The results of this study suggest a simple and easy-to-use scoring system to predict CO-BSIs caused by ESBL-producing E. coli and Klebsiella species.

Area Under Curve , beta-Lactamases , Cohort Studies , Escherichia coli , Escherichia , Hospitalization , Klebsiella , Logistic Models , Urinary Catheters
Article in Korean | WPRIM | ID: wpr-766913


PURPOSE: To investigate the clinical features and prognosis associated with endogenous endophthalmitis (EE) in western Gyeongsangnam-do over an 11-year period. METHODS: This study was a retrospective review of the medical records of 24 patients (33 eyes) who presented with endogenous endophthalmitis at the Gyeongsang National University Hospital from 2007 to 2017. RESULTS: The mean age of onset was 63.2 years, and 58.3% of the patients were men. Bilateral involvement was observed in nine patients (37.5%). Liver abscess (30.3%) and urinary tract infection (24.2%) were the most common extraocular sources of infection. Positive culture result was noted in 72.7% of the patients. The most common causative agents were gram-negative organisms (45.8%); the most commonly isolated microorganism was Klebsiella pneumoniae. Vitreous tapping and intravitreal antibiotic injection were performed in all patients; pars plana vitrectomy with intravitreal injection of antibiotics was performed in 12 eyes (36.4%). Enucleation and evisceration were performed in six eyes (18.2%). Initial visual acuity worse than hand motion was associated with a significantly worse visual outcome (p = 0.001). CONCLUSIONS: In our study, EE showed a poor visual prognosis, irrespective of treatment. Poor initial visual acuity was predictive of poor visual outcome. Liver abscess and urinary tract infections were common extraocular sources of EE and K. pneumoniae was the most common causative organism.

Age of Onset , Anti-Bacterial Agents , Endophthalmitis , Hand , Humans , Intravitreal Injections , Klebsiella , Klebsiella pneumoniae , Liver Abscess , Male , Medical Records , Pneumonia , Prognosis , Retrospective Studies , Urinary Tract Infections , Visual Acuity , Vitrectomy
Article in Spanish | LILACS | ID: biblio-1150791


El género Klebsiella tiene importancia en hospitales y sanatorios por su tendencia a causar brotes. Una característica sobresaliente es la resistencia natural y/o adquirida a antimicrobianos. Según la red WHONET - Argentina, existe circulación de Klebsiella en nosocomios, particularmente en salas de terapia intensiva. En este trabajo se evaluó la presencia de Klebsiella spp. en 1233 pacientes de un sanatorio de la ciudad de Resistencia (Chaco), durante el período 2015 ­ 2017. La detección de la bacteria se realizó por cultivo y la sensibilidad se determinó por difusión en agar. Se detectó Klebsiella en 5.6% (69) de las muestras y multirresistencia en 84% de los aislamientos. Se concluye que existe circulación de Klebsiella en la institución, debe ser correctamente identificada y establecido su nivel de resistencia. Esto es fundamental para disminuir los fracasos terapéuticos

The Klebsiella genus is important in hospitals and sanatoriums because of its tendency to cause outbreaks. An outstanding characteristic is the natural and / or acquired resistance to antimicrobials. According to the WHONET-Argentina network, there is Klebsiella circulation in hospitals, particularly in intensive care rooms. In this work, we searched Klebsiella spp. in 1233 patients from a sanatorium in the city of Resistencia (Chaco), during the period 2015 - 2017. The detection of the bacteria was carried out by culture and the sensitivity was determined by agar diffusion. Klebsiella was detected in 5.6% (69) of the samples and multiresistance in 84% of the isolates. It is concluded that there is Klebsiella circulation in the institution, it must be correctly identified and its level of resistance established. This is essential to reduce therapeutic failures

Humans , Bacteria/isolation & purification , Bacterial Infections/diagnosis , Disease Outbreaks , Hospitals , Klebsiella , Nursing Homes , Patients
Rev. epidemiol. controle infecç ; 9(2): 129-133, 2019. ilus
Article in Portuguese | LILACS | ID: biblio-1021767


Justificativa e Objetivos: Bactérias produtoras de betalactamase de espectro ampliado (ESBL) são crescentes, sobretudo, pelo uso rotineiro de antibióticos. Causam principalmente, infecções urinárias e de feridas operatórias e, caracterizam-se pela resistência às cefalosporinas de terceira geração, aztreonam e associação de cefalosporinas com ácido clavulânico. Este estudo teve como objetivo conhecer a frequência de Escherichia coli ESBL e Klebsiella spp. ESBL através da análise fenotípica. Métodos: Teste de sensibilidade in vitro por aproximação de discos (CLSI), de bactérias isoladas de meios biológicos dos pacientes atendidos no HUGV entre 2017 e 2018. Resultados: 34,66% eram Escherichia coli ESBL e 46,80% Klebsiella spp. ESBL, totalizando 39,34% de amostras ESBL. Dos meios biológicos predominaram ESBL na: urina (56,25%) e feridas cirúrgicas (22,91%). Clínicas com maior ocorrência de ESBL: médica e cirúrgica. Conclusão: Os índices de ESBL no HUGV estão próximos ou até mais altos do que em algumas regiões do país. Consoante a literatura revisada, predomina a Escherichia coli nos isolados e há mais Klebisella spp. ESBL do que Escherichia coli ESBL.(AU)

Background and Objectives: Extended-spectrum beta-lactamase (ESBL) producing bacteria are increasingly present, above all, by the routine use of antibiotics. They mainly cause urinary and operative wound infections and are characterized by resistance to third- -generation cephalosporins, aztreonam and the association of cephalosporins with clavulanic acid. This study has objective to know the frequency of ESBL Escherichia coli and Klebsiella spp., through phenotype. Methods: In vitro sensitivity test by disk approximation (CLSI) of the bacteria isolated from biological materials of patients attended in HUGV between 2017 and 2018 and analysis in Microsoft Office Excel software, v. 2016, for calculation of frequencies. Results: 34.66% were Escherichia coli ESBL and 46.80% Klebsiella spp. ESBL totaling 39.34% ESBL samples. Of the biological media ESBL were predominant in: urine (56.25%) and surgical wounds (22.91%). Clinics with greater occurrence of ESBL: medical and surgical. Conclusion: The ESBL indices in the HUGV are close or even higher than in some regions of the country. According to the revised literature, Escherichia coli predominates in isolated and there is more Klebisella spp. ESBL than Escherichia coli ESBL.(AU)

Justificación y objetivos: Las bacterias productoras de betalactamasa de espectro extendido (ESBL) están cada vez más presentes, sobre todo, por el uso rutinario de antibióticos, causan principalmente infecciones urinarias y de heridas operativas y se caracterizan por la resistencia a las cefalosporinas de tercera generación, aztreonam y asociación de cefalosporinas. Este estudio tiene como objetivo determinar la prevalencia de Escherichia coli y Klebsiella sp. ESBL, a través de análisis fenotípico. Métodos: Prueba de sensibilidad in vitro por aproximación de discos (CLSI) de bacterias aisladas de medios biológicos de los pacientes atendidos en el HUGV entre 2017 y 2018, y análisis en el software Microsoft Office Excel, v. 2016, para cálculos de frecuencia. Resultados: 34,66% eran Escherichia coli ESBL y 46,80% Klebsiella spp. ESBL, totalizando 39,34% de muestras ESBL. De los medios biológicos predominaron ESBL en: orina (56,25%) y heridas quirúrgicas (22,91%). Clínicas con mayor ocurrencia de ESBL: médica y quirúrgica. Conclusión: Los índices de ESBL en HUGV son cercanos o incluso más altos que en algunas regiones del país. Según la literatura revisada, Escherichia coli predomina en los aislados y hay más Klebisella spp. ESBL que Escherichia coli ESBL.(AU)

Humans , Phenotype , Cross Infection , Escherichia coli , Klebsiella
Article in English | WPRIM | ID: wpr-764235


We investigated the effect of toxin-antitoxin (TA) systems in bla(CTX-M-15)-bearing plasmids of Klebsiella pneumoniae on persister formation. The persister formation rate was notably high in transconjugants in plasmids bearing TA system than the transconjugants in plasmids bearing no TA systems. Activation of relA and spoT expression was higher in transconjugants with plasmids bearing TA systems. Thus, TA systems in plasmids may contribute to the maintenance of bla(CTX-M-15)-bearing plasmids and host survival via persister formation.

Klebsiella pneumoniae , Klebsiella , Plasmids
Article in English | WPRIM | ID: wpr-760850


Pyogenic liver abscess (PLA) can be caused by bacteria entering the liver via the portal vein or primary bacteremia, or it can be cryptogenic. Recently, Klebsiella pneumoniae has been increasingly found as a PLA pathogen. PLA due to this bacterium often leads to formation of extrahepatic abscesses. The treatment of choice is dual therapy with insertion of percutaneous catheter drainage and antibiotic therapy. We report 2 cases of PLA due to K. pneumoniae in immunocompetent children. We successfully treated patient 1 with percutaneous catheter drainage for 18 days and 6-week course of antibiotic therapy. Patient 2 was treated with percutaneous needle aspiration and antibiotic therapy for the same period. In both patients, the PLAs showed the ultrasound-confirmed resolutions after the dual therapy.

Abscess , Anti-Bacterial Agents , Bacteremia , Bacteria , Catheters , Child , Drainage , Humans , Immunocompetence , Klebsiella pneumoniae , Klebsiella , Liver , Liver Abscess, Pyogenic , Needles , Pneumonia , Portal Vein
Article in English | WPRIM | ID: wpr-714239


Nowadays, Klebsiella oxytoca is described as a causative organism for antibiotic-associated hemorrhagic colitis (AAHC). Here we report two cases of pediatric AAHC, from which K. oxytoca was cultured after starting amoxicillin-clavulanate or amoxicillin treatment. The patients developed severe abdominal pain and a large amount of bloody diarrhea. K. oxytoca was obtained in intestinal fluid culture of a boy through the colonoscopy. On the other hand, colonic tissue culture and intestinal fluid culture were negative of the other patient. K. oxytoca was detected in stool culture when he was admitted. These cases showed characteristic endoscopic findings of segmental hemorrhagic colitis, and both boys recovered spontaneously within 2–3 days after they stopped taking the antibiotics. Therefore, in children who develop relatively large amount of bloody diarrhea after antibiotic treatment, we should consider AAHC caused by K. oxytoca.

Abdominal Pain , Amoxicillin , Anti-Bacterial Agents , Child , Colitis , Colon , Colonoscopy , Diarrhea , Hand , Humans , Klebsiella oxytoca , Klebsiella , Male
Article in English | WPRIM | ID: wpr-713308


The thyroid is resistant to infection due to its anatomical and physiological characteristics. We present a rare case of invasive liver abscess with metastatic thyroid abscess and endogenous endophthalmitis in a previously healthy 55-year-old female patient without diabetes or other medical illness. This report raises an important question of the virulence of Klebsiella pneumoniae as an increasingly common causative agent of liver abscess.

Abscess , Endophthalmitis , Female , Humans , Klebsiella pneumoniae , Klebsiella , Liver Abscess , Liver , Middle Aged , Thyroid Gland , Virulence