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An. bras. dermatol ; 96(3): 352-354, May-June 2021. graf
Article in English | LILACS | ID: biblio-1285072


Abstract Cutaneous leishmaniasis is characterized by ulcers with raised edges and a granular bottom, mainly on the lower limbs. This is a case report of a male patient with an ulcer on the left plantar region. The diagnosis was confirmed by positive PCR for L. braziliensis and the presence of amastigotes of Leishmania sp. in the histopathological examination. After treatment with Glucantime, the patient showed full healing of the ulcer. The unusual location of the ulceration calls attention to atypical presentations of leishmaniasis, and the importance of histopathological examination and PCR, leading to the appropriate diagnosis and treatment.

Humans , Male , Leishmania braziliensis , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/drug therapy , Foot Ulcer , Leishmania , Ulcer , Meglumine Antimoniate
Rev. Soc. Bras. Med. Trop ; 54: e00472020, 2021. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS, SES-SP | ID: biblio-1143886


Abstract INTRODUCTION: The objective of this study was to evaluate the performance of filter paper (FP) for lesion scraping collection in a polymerase chain reaction (PCR) for cutaneous leishmaniasis (CL) diagnosis. METHODS: Lesion scrapings from 48 patients were collected and analyzed for PCR. RESULTS: PCR with FP detected up to three Leishmania braziliensis promastigotes. Considering the direct search by microscopy or PCR of samples collected in STE buffer as standards, the sensitivity of PCR with FP was 100%. CONCLUSIONS: FP can be useful for CL diagnosis in remote regions, allowing high sensitivity in the detection of the parasite by PCR.

Humans , Leishmania braziliensis/genetics , Leishmaniasis, Cutaneous/diagnosis , Polymerase Chain Reaction , DNA, Protozoan/genetics , Sensitivity and Specificity , Microscopy
Rev. Soc. Bras. Med. Trop ; 54: e0514-2020, 2021. tab, graf
Article in English | LILACS | ID: biblio-1155581


Abstract A 31-year-old male patient developed an ulcer on the glans penis that evolved for three months without healing. We diagnosed it as leishmaniasis using polymerase chain reaction. No immunosuppression or associated diseases were observed. The patient was treated with meglumine antimoniate that cured the lesion in a month post-treatment. Here, we report this case of cutaneous leishmaniasis lesion at the unusual location of glans penis in an immunocompetent individual. The lesion likely developed due to the bite of a vector, highlighting the need for considering cutaneous leishmaniasis among differential diagnosis of sexually transmitted diseases in areas endemic for leishmaniasis.

Humans , Male , Adult , Organometallic Compounds/therapeutic use , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/drug therapy , Antiprotozoal Agents/therapeutic use , Brazil , Polymerase Chain Reaction , Meglumine Antimoniate/therapeutic use , Genitalia , Meglumine/therapeutic use
Rev. Soc. Bras. Med. Trop ; 54: e0772-2020, 2021. graf
Article in English | LILACS | ID: biblio-1155577


Abstract Leishmaniasis is a tropical infectious disease caused by Leishmania spp. protozoa and is transmitted by insects from the Phlebotominae subfamily. It can manifest as cutaneous leishmaniasis, a painless ulcer that can develop into a more serious systemic affliction as the protozoa spreads lymphatically or hematogenously, depending on the host's immunity. In this case series, the authors present a rare form of genital mucocutaneous leishmaniasis, with consideration of epidemiologic characteristics, clinical presentation, differential diagnosis, and treatments offered.

Animals , Leishmaniasis, Mucocutaneous/diagnosis , Leishmaniasis, Cutaneous/diagnosis , Leishmania , Ulcer , Diagnosis, Differential , Genitalia
Rev. Soc. Bras. Med. Trop ; 54: e0305-2020, 2021. graf
Article in English | LILACS | ID: biblio-1155563


Abstract Cutaneous leishmaniasis (CL) involves several differential diagnoses as it lacks a gold standard diagnostic test. Its diagnosis is easier in endemic regions; however, many cases come from travelers to endemic areas. A 22-year-old patient, who had recently visited Oaxaca, Mexico, developed two asymptomatic ulcers weeks later on the left auricle and the nose. Leishmania mexicana was identified using polymerase chain reaction. The patient was treated with imiquimod 5% cream three times/week, providing favorable results after 12 weeks, without relapse 2 months after therapy. To our knowledge, this is the first case of CL due to L. mexicana effectively treated with imiquimod.

Humans , Young Adult , Leishmania mexicana , Leishmaniasis, Mucocutaneous , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/drug therapy , Imiquimod , Mexico
An. bras. dermatol ; 95(5): 641-644, Sept.-Oct. 2020. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130931


Abstract Genital lesions are an unusual presentation of American cutaneous leishmaniasis. Conditions such as disseminated cutaneous leishmaniasis and HIV infection may be associated with genital involvement. The authors present five cases of American cutaneous leishmaniasis with genital lesions and discuss the clinical and epidemiological aspects observed in this case series.

Humans , Leishmania braziliensis , Leishmaniasis, Mucocutaneous , HIV Infections , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , United States , Genitalia
Rev. Soc. Bras. Med. Trop ; 53: e20200083, 2020. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS, SES-SP | ID: biblio-1143876


Abstract INTRODUCTION: Brazil has a high number of cases of American cutaneous leishmaniasis (ACL) in the north and northeast regions. Therefore, continuous surveillance of environmental and socioeconomic factors in endemic areas is needed to develop strategic control measures. This study aimed to describe the clinical and epidemiological profiles of patients with ACL. METHODS: All patients were from the states of Amazonas and Pernambuco, and examinations were carried out between 2015 and 2018. All patients had a clinical and epidemiological history compatible with ACL after positive diagnostic tests. Information obtained from medical records included gender, employment activity, level of education, age, and number and sites of lesions. RESULTS: A total of 213 patients were included, of whom 30.98% were female and 69.02% were male. The main employment activity was agriculture (27.56%). The most common level of education was elementary (62.42%). The average age was approximately 39 years. The majority of the patients presented only with one lesion (54.87%), and legs/feet were the most commonly affected area (48.25%), followed by the arms/hands (44.75%). CONCLUSIONS: These data demonstrated that irrespective of the patients' places of origin, interventions need to be focused on men of economically productive age, in view of the high risk of exposure to the vector in this group. Education activities need to be directed to farmers about the importance of protection against ACL vectors during work. Such information must also be directed to employers as a way of implementing and maintaining appropriate working conditions and stepping up vector control.

Humans , Male , Female , Adult , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , Socioeconomic Factors , United States , Brazil/epidemiology , Disease Vectors , Educational Status
Rev. Soc. Bras. Med. Trop ; 53: e20200255, 2020. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS, SES-SP | ID: biblio-1143862


Abstract INTRODUCTION: In the Belém Metropolitan Region (BMR), Pará State, Brazil, American cutaneous leishmaniasis (ACL) is endemic; however, very little is known regarding its causative agents. Therefore, we used our standard diagnostic approach combined with an RNA polymerase II largest subunit (RNAPOIILS)-polymerase chain reaction (PCR) followed by analysis of restriction fragment length polymorphism (PCR-RFLP) to identify Leishmania spp. ACL agents in this region. METHODS: Thirty-two Leishmania spp. isolates from patients with ACL in the BMR during 1995-2018 were analyzed. Leishmania spp. DNA samples were amplified using the primers RPOR2/RPOF2, and the 615-bp PCR products were subjected to enzymatic digestion using TspRI and HgaI endonucleases. RESULTS: ACL etiological agents in the BMR comprised Leishmania (Viannia) lindenbergi (43.7%) followed by Leishmania (Viannia) lainsoni (34.4%), Leishmania (Leishmania) amazonensis (12.5%), and Leishmania (Viannia) braziliensis (9.4%). CONCLUSIONS: To our knowledge, the results of the study revealed for the first time that L. (V.) lindenbergi and L. (V.) lainsoni are the main ACL agents in BMR.

Humans , Leishmania braziliensis/genetics , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , Leishmania/genetics , United States , Brazil/epidemiology , Leishmaniasis, Cutaneous
Rev. Soc. Bras. Med. Trop ; 53: e20200006, 2020. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS, SES-SP | ID: biblio-1136892


Abstract INTRODUCTION: We diagnose cases of cutaneous leishmaniasis (CL) among indigenous peoples of the state of Roraima, Brazil, and discuss some aspects of its epidemiology. METHODS: Skin imprints, and lesion exudate samples collected on filter paper were examined using parasitological and molecular techniques, respectively. RESULTS: Of 30 indigenous individuals, representing several ethnic groups, with suspected cases of CL, 27 (90%) tested positive for Leishmania spp. by PCR, and 21 (70%) by parasitological microscopy. CONCLUSIONS: Cutaneous leishmaniasis is indistinctly present among indigenous peoples from different regions of the state of Roraima. Individuals from seven of the ten existing ethnic groups in the state tested positive for CL, demonstrating the need for further investigation of the disease among these ethnic groups.

Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Young Adult , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , Leishmania/genetics , Brazil/epidemiology , Polymerase Chain Reaction , Indigenous Peoples , Middle Aged
Rev. Soc. Bras. Med. Trop ; 53: e20190380, 2020. graf
Article in English | LILACS | ID: biblio-1057262


Abstract Tegumentary leishmaniasis (TL) diagnosis is challenging due to the lack of a gold standard diagnostic tool. The diagnosis is significantly harder in regions where visceral leishmaniasis (VL) is also prevalent since immunological tests may present cross-reactivity. A cirrhotic patient from an endemic Brazilian region for TL and VL presented with atypical cutaneous lesions, a usual clinico-laboratory feature of VL (including a positive rk39 test result), but he was diagnosed with TL histopathologically; VL was ruled out by necropsy. Physicians working in co-prevalent areas should be aware of atypical features, unusual clinical course, and unexpected laboratory findings of leishmaniasis.

Humans , Male , Leishmaniasis, Cutaneous/pathology , Leishmaniasis, Visceral/diagnosis , Liver Cirrhosis/complications , Leishmaniasis, Cutaneous/complications , Leishmaniasis, Cutaneous/diagnosis , Fatal Outcome , Diagnosis, Differential , Middle Aged
Rev. chil. infectol ; 36(6): 707-715, dic. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1058102


Resumen Introducción: La leishmaniasis es una enfermedad infecciosa que presenta una elevada prevalencia e incidencia mundial, causando alrededor de 70.000 muertes anuales. Objetivo: Determinar el perfil clínico y epidemiológico de los casos de leishmaniasis tegumentaria en la Provincia de Ambo, Departamento de Huánuco, Perú, durante el período: años 2000 a 2017. Métodos: Se realizó un estudio descriptivo, observacional, retrospectivo y transversal de base poblacional. Resultados: Se identificaron 1.312 pacientes confirmados de leishmaniasis tegumentaria. La forma clínica cutánea tuvo una mayor prevalencia en comparación a la muco-cutánea (83,2 vs 16,7%). La infección en el género masculino tuvo mayor predominio frente al femenino (53,3 vs 46,6%). La mayor tasa de incidencia anual reportada fue de 412,67/100.000 habts. durante el año 2000 mientras que la menor registrada fue en el 2015 con 24,45/100.000 habts. El Distrito de Ambo fue el más afectado con la forma clínica cutánea (43,1%) y la muco-cutánea (38,2%) de la enfermedad. El principal método diagnóstico para ambas formas clínicas fue el examen microscópico directo (82,0 vs 81,0%) y la terapia más utilizada fue con estibogluconato de sodio (85,6 vs 78,6%). Se reportó falla al tratamiento de 25% para ambas presentaciones clínicas. Conclusiones: Las condiciones eco-ambientales de esta zona del Perú han permitido el establecimiento de la leishmaniasis tegumentaria; mostrando tendencias similares a las comunicadas en la literatura mundial. Sin embargo, se necesitan más investigaciones que expliquen el comportamiento epidemiológico de esta enfermedad y permitan crear modelos de predicción epidemiológica para un control adecuado y oportuno.

Background: Leishmaniasis is an infectious disease with a high prevalence and worldwide incidence, causing around 70,000 deaths per year. Aim: To determine the clinical and epidemiological profile of cases of tegumentary leishmaniasis in the Province of Ambo, Department of Huánuco, Peru, during the period from 2000 to 2017. Methods: A descriptive, observational, retrospective and cross-sectional study was conducted population base. Results: We identified 1,312 confirmed cases of tegumentary leishmaniasis, the cutaneous clinical form had a higher prevalence compared to mucocutaneous (83.2 vs 16.7%). The infection in the masculine gender had greater predominance in front of the feminine one (53.3 vs 46.6%). The highest reported annual incidence rate was 412.67/ 100,000 inhabitants during the year 2000 while the lowest registered was in 2015 with 24.45/ 100,000 inhabitants. The Ambo district was the most affected in the clinical cutaneous form (43.1%) as mucocutaneous (38.2%) of the disease. The main diagnostic method for both clinical forms was microscopy (82.0 vs 81.0%) and the most used therapy was sodium stibogluconate (85.6 vs 78.6%). Failure to treatment was reported in 25% for both presentations clinics. Conclusions: The eco-environmental conditions of this area of Peru have allowed the establishment of tegumentary leishmaniasis; showing trends similar to world literature. However, more research is needed to explain the epidemiological behavior of this disease that allows the creation of epidemiological prediction models for timely and adequate control.

Humans , Leishmaniasis , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , Peru/epidemiology , Incidence , Cross-Sectional Studies , Retrospective Studies
Med. leg. Costa Rica ; 36(2): 82-94, sep.-dic. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1040448


Resumen La Leishmaniasis es un complejo de enfermedades causadas por un grupo heterogéneo protozoos pertenecientes al género Leishmania sp. Se transmite a los humanos a través de vectores, que en nuestro país corresponden a mosquitos. En Costa Rica la provincia de Limón presenta la mayor cantidad de casos, concentrándose principalmente en el cantón de Talamanca. Existen 3 formas clínicas, centrándose esta revisión en la forma cutánea de la infección. A pesar del número importante de casos que ocurren cada año en el país, el manejo de la enfermedad así como las distintas opciones terapéuticas no se encuentran difundidas entre los médicos de atención primaria. Se cuenta con algunas guías internacionales como las de la IDSA o la OMS, sin embargo no todas las opciones terapéuticas son accesibles para todos los médicos, aún más en la Seguridad Social. La presente revisión contempla la clínica, el diagnóstico y el tratamiento de Leishmaniasis cutánea con un enfoque desde la realidad costarricense.

Abstract Leishmaniasis is a complex of diseases caused by a heterogeneous group of protozoa belonging to the genus Leishmania sp. It is transmitted to humans through vectors, which in our country corresponds to mosquitoes. In Costa Rica, the province of Limón has the highest number of cases, concentrating mainly in the canton of Talamanca. There are 3 clinical forms, focusing this review on the cutaneous infection. Despite the significant number of cases that occur every year in the country, the management of the disease and the therapeutic options are not widespread among primary care physicians. There are some international guidelines such as those from the IDSA or the WHO; however, we do not have all the therapeutic options available to all doctors, even more so in the Social Security. The present review contemplates the clinical facts, diagnosis and treatment of cutaneous leishmaniasis with a focus from the Costa Rican reality.

Humans , Protozoan Infections , Leishmaniasis , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , Costa Rica
Rev. bras. anal. clin ; 51(2): 127-131, 20191011. ilus
Article in Portuguese | LILACS | ID: biblio-1024908


Objetivo: Analisar biópsias de pele de pacientes com suspeita de hanseníase e LTA atendidos no serviço de dermatologia de um hospital público de Recife-PE. Métodos: Trata-se de um estudo de caráter retrospectivo, transversal, descritivo, qualitativo no qual foram analisadas biópsias de pele de pacientes com suspeita de hanseníase e/ou LTA, atendidos no serviço de dermatologia do Hospital das Clínicas, Recife-PE, no período de janeiro de 2016 a abril de 2018. Resultados: Um total de 46 pacientes com suspeita de hanseníase e/ou LTA foi atendido, as idades variaram entre 13 a 90 anos, 22 pacientes eram do sexo feminino e 24 do sexo masculino. Dentre esses 46 pacientes, havia 25 (54%) com suspeita de leishmaniose, sendo 10 (40%) confirmados com positividade para Leishmania braziliensis pela PCR, e 12 (26%) confirmados para hanseníase. Conclusão: A análise histopatológica contribuiu para confirmação e diagnóstico diferencial entre hanseníase e leishmaniose tegumentar, além de auxiliar na diferenciação com outras doenças de características clínicas semelhantes.

Objective: To analyze the skin biopsies of patients with suspicion of leprosy and LTA treated at the dermatology department of a public hospital in Recife-PE. Methods: This was a cross-sectional, descriptive and qualitative retrospective study of skin biopsies of patients with suspected leprosy and/or ACL, treated at the dermatology department of the Hospital das Clínicas, Recife, period from January 2016 to April 2018. Results: A total of 46 patients with suspected leprosy and/or LTA were attended, ages ranged from 13 to 90 years, 22 were female and 24 were male. Among these 46 patients, 25 (54%) with suspected leishmaniasis, with 10 (40%) confirmed positive for Leishmania braziliensis by PCR, and 12 (26%) confirmed for leprosy. Conclusion: The histopathological analysis contributed for confirmation and differential diagnosis of leprosis and cutaneous leishmaniasis, moreover it served to help in the differentiation of other diseases with similar clinical characteristics

Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Biopsy , Leishmaniasis, Cutaneous/diagnosis , Diagnosis, Differential , Leprosy/diagnosis
Medicina (B.Aires) ; 79(4): 287-290, ago. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1040524


La histoplasmosis y la leishmaniasis son enfermedades olvidadas, endémicas en Argentina, y generalmente se asocian a inmunocompromiso. Presentamos el caso de un varón de 16 años, inmunocompetente, con histoplasmosis del sistema nervioso central y leishmaniasis cutánea. Inicialmente, el paciente presentó una lesión en la pierna de un mes de evolución seguida de paraparesia leve, diagnosticada como un proceso de desmielinización mediante estudios de imágenes. El cuadro fue tratado con altas dosis de corticoides y en 72 horas evolucionó a paraparesia grave con lesiones nodulares en las vértebras cervicales, observadas en las imágenes de resonancia magnética nuclear. Se aisló Histoplasma capsulatum de líquido cefalorraquídeo, genotípicamente identificado como perteneciente a la especie filogenética LamB. El paciente recibió tratamiento intravenoso con anfotericina B deoxicolato durante 30 días y posteriormente fluconazol e itraconazol oral durante un año. A los tres meses de iniciado el tratamiento con antifúngicos se reactivó la lesión de la pierna y en el examen directo se observaron amastigotes de Leishmania. La leishmaniasis cutánea fue tratada con antimoniato de meglumina intramuscular. La respuesta clínica al tratamiento de ambas enfermedades fue favorable.

Histoplasmosis and leishmaniasis are neglected and endemic diseases in Argentina, and generally are found associated with immunosuppression. We report the case of an immunocompetent 16-years-old man with simultaneous occurrence of central nervous system histoplasmosis and cutaneous leishmaniasis. Upon admission, the patient showed a one-month old skin lesion in a leg and mild paraparesis. Imaging studies detected thickening and edema in the spinal cord and the cerebrospinal fluid analysis was within normal range. The case was diagnosed as a demyelinating disorder and treated with high-dose short-term steroids. Seventy-two hours later the patient showed severe paraparesis and nuclear magnetic resonance imaging revealed nodular lesions in the spinal cord. Histoplasma capsulatum belonging to the phylogenetic species LamB was isolated from cerebrospinal fluid samples. The patient received intravenous antifungal therapy with amphotericin B for 30 days, followed by oral fluconazole and itraconazole for one year. Three months after initiation of antifungal treatment, the cutaneous lesion recrudesced and Leishmania amastigotes were observed on microscopic examination. The cutaneous leishmaniasis was treated with intramuscular meglumine antimoniate. The patient´s outcome was favorable after treatment for both diseases.

Humans , Male , Adolescent , Leishmaniasis, Cutaneous/complications , Central Nervous System Fungal Infections/complications , Histoplasmosis/complications , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/drug therapy , Central Nervous System Fungal Infections/diagnosis , Central Nervous System Fungal Infections/drug therapy , Histoplasmosis/diagnosis , Histoplasmosis/drug therapy , Immunocompetence , Anti-Bacterial Agents/administration & dosage , Antifungal Agents/administration & dosage
Rev. bras. parasitol. vet ; 28(2): 194-202, Apr.-June 2019. tab
Article in English | LILACS | ID: biblio-1013740


Abstract The aim of this study was to compare molecular tests used to diagnose Leishmania spp. in dogs with different stages of infection. Blood and conjunctival swab (CS) samples from dogs classified in four clinical stages were subjected to different PCR protocols (13A/13B, MC1/MC2, LITSR/L5.8S and LEISH-1/LEISH-2 primers). To the study, 22.3% (48/215) of dogs were classified as without clinical signs, 67.5% (145/215) stage I (mild disease), 7.0% (15/215) stage II (moderate disease) and 3.2% (7/215) stage III (severe disease). The results showed that in blood samples, 13A/13B detected a significant higher number of positive dogs in stage I (25/145) and in total (42/215) (p≤0.05). However, when CS samples were tested, no difference was observed (p>0.05). On the other hand, in blood samples, MC1/MC2 detected significantly fewer positive dogs classified as without clinical signs (0/48), in stage I (0/145) and in total (1/215) (p≤0.05). Likewise, in CS samples, this primers showed also lower detection (1/215) (p≤0.05). So than, we can conclude that PCR on blood samples with 13A/13B primers has greater capacity to detect positive dogs, mainly at the initial of clinical disease than do other primers and MC1/MC2 are not a good choice to detect Leishmania infantum infection in dogs.

Resumo O objetivo deste estudo foi comparar testes moleculares usados para diagnosticar Leishmania spp., em cães apresentando diferentes estágios de infecção. Amostras de sangue e suabe conjuntival (SC) de cães classificados em quatro estágios clínicos foram submetidas a diferentes PCRs (primers 13A/13B, MC1/MC2, LITSR/L5.8S e LEISH-1/LEISH-2). Para o estudo, 22,3% (48/215) dos cães foram classificados como sem sinais clínicos, 67,5% (145/215) estágio I (doença leve), 7,0% (15/215) estágio II (doença moderada) e 3,2% (7/215) estágio III (doença grave). Os resultados mostraram que, em amostras de sangue, 13A/13B detectou número significativamente maior de cães positivos no estágio I (25/145) e no total (42/215) (p≤0,05). No entanto, quando as amostras de SC foram testadas, nenhuma diferença foi observada (p>0,05). Por outro lado, no sangue, MC1/MC2 detectou significativamente menos cães positivos sem sinais clínicos (0/48), em estágio I (0/145) e no total (1/215) (p≤0,05). Da mesma forma, em amostras de SC, MC1/MC2 também apresentou menor detecção (1/215) (p≤0,05). Assim, a PCR em amostras de sangue com 13A/13B tem maior capacidade de detectar cães positivos, principalmente no início da doença do que outros primers, e o par de primers MC1/MC2 não é uma boa escolha para detectar infecção por Leishmania infantum em cães.

Animals , Dogs , Leishmaniasis, Cutaneous/veterinary , Dog Diseases/diagnosis , Leishmaniasis, Visceral/veterinary , Severity of Illness Index , Brazil/epidemiology , DNA, Protozoan/genetics , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology , Leishmania infantum/genetics , Dog Diseases/epidemiology , Real-Time Polymerase Chain Reaction/veterinary , Leishmaniasis, Visceral/diagnosis , Leishmaniasis, Visceral/epidemiology
Mali méd. (En ligne) ; 34(2): 12-17, 2019. ilus
Article in French | AIM, AIM | ID: biblio-1265738


De nombreux cas de leishmaniose cutanée sont observés lors des consultations hospitalières à Nouakchott. L'objectif de notre étude est de recueillir tous les cas de leishmanioses cutanées à Nouakchott et d'en étudier les caractéristiques épidémiologiques et clinico-biologiques. Méthode : Il s'agit d'une étude multicentrique descriptive prospective réalisée dans 2 services hospitaliers spécialisés de Nouakchott du 1er septembre 2016 à la fin du mois d'octobre 2017. Tous les patients présentant des lésions suspectes de leishmaniose cutanée durant cette période ont été retenus. Un prélèvement cutané à visée parasitologique, une PCR et une histologie ont été effectués aux patients. Résultats : Vingt et un patients sur 9000 consultants ont été diagnostiqués durant la période d'étude, avec un âge moyen de 23 ans (variant de 3 à 70 ans). Une prédominance masculine a été notée avec un sexe ratio de 2/1. Les localisations les plus fréquentes sont les parties découvertes du corps (les 4 membres). La forme ulcéro-crouteuse est rencontrée dans 2/3 des cas. L. major est plus fréquemment identifiée (61,9 %) suivi de L infantum dans 23,8% des cas. L'Antimoniate de Meglume a été administré par voie intralésionnelle chez 57,1% des patients. A Nouakchott, la Leishmaniose cutanée n'est pas rare. Les cas observés sont liés à une origine ou un séjour dans les régions du Sud

Leishmaniasis, Cutaneous , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/epidemiology
Rev. Soc. Bras. Med. Trop ; 51(6): 837-842, Nov.-Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-1041496


Abstract INTRODUCTION This study characterized the clinico-epidemiological profile of American cutaneous leishmaniasis (ACL) cases in Barbalha, Ceará State, Brazil. METHODS Medical records of 363 patients visiting Federal University of Cariri between 2009 and 2014 were analyzed. RESULTS ACL was more prevalent in men with low education level from rural zones. The main presentation was a single ulcer, mainly in the lower limbs, and 49.8% also presented lymphadenomegaly. The annual incidence ranged from 2.83 to 22.60 per 10,000 inhabitants. CONCLUSIONS: The rates observed in this study indicate the importance of additional research to contribute to the control of this endemic disease.

Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Young Adult , Leishmaniasis, Cutaneous/epidemiology , Rural Population , Socioeconomic Factors , Brazil/epidemiology , Incidence , Prevalence , Retrospective Studies , Leishmaniasis, Cutaneous/diagnosis , Middle Aged