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1.
J. Health Biol. Sci. (Online) ; 10(1): 1-7, 01/jan./2022.
Article in Portuguese | LILACS | ID: biblio-1361634

ABSTRACT

Objetivo: aplicar a modelagem logística da primeira onda da COVID-19, com índice nos países com 20 maiores Produto Interno Bruto (PIB). Métodos: foi utilizada a modelagem matemática de crescimento logístico, considerando os seguintes parâmetros: número cumulativo de casos (C), tamanho final da epidemia na onda única de um surto (K), taxa intrínseca de crescimento (y) e tempo de inflexão (τ). Resultados: o Brasil apresentou maior número de casos e mortalidade, e os Estados Unidos da América (EUA) maior número de casos absolutos. A Coreia do Sul evidenciou o menor ponto de inflexão de 15,3 dias, enquanto o maior foi da Indonésia, com 213,9 dias. Na análise entre o ponto de inflexão e casos acumulados (/100 mil habitantes), observou-se correlação positiva moderada significativa (r=0,629 e p=0,003); (r=0,532 e p=0,016). Conclusão: o reconhecimento do comportamento de uma epidemia por meio da modelagem matemática torna possível determinar a propagação de uma epidemia, visto que, com a possibilidade de captar a dinâmica de uma epidemia, torna-se possível prever a necessidade de medidas públicas antecipadas e, consequentemente, diminuição da mortalidade global.


Objective: to apply logistic modeling of the first wave of COVID-19 in countries with the 20 highest Gross Domestic Product (GDP). Methods: logistic growth mathematical modeling was used, considering the following parameters: cumulative number of cases (C), the final size of the epidemic in the single wave of an outbreak (K), intrinsic growth rate (y), and inflection time (τ). Results: Brazil showed the highest number of cases and mortality, and the United States of America (USA) had the highest number of absolute cases. South Korea showed the lowest inflection point of 15.3 days, while the highest infection point was Indonesia, with 213.9 days. In the analysis between the inflection point and cumulative cases (/100,000 population), a moderate significant positive correlation was observed (r=0.629 and p=0.003); (r=0.532 and p=0.016). Conclusion: the recognition of the behavior of an epidemic through mathematical modeling makes it possible to determine the spread of an epidemic, since, with the possibility of capturing the dynamics of an epidemic, it becomes possible to predict the need for anticipated public measures and, consequently, decrease in overall mortality.


Subject(s)
COVID-19 , Logistic Models , Gross Domestic Product , Epidemics
2.
Rev. Ciênc. Plur ; 8(3): 28522, out. 2022. tab, graf
Article in Portuguese | LILACS, BBO | ID: biblio-1399323

ABSTRACT

Introdução: Assim como observado no cenário nacional, o município de Mossoró apresentou altas taxas de letalidade nos primeiros meses de pandemia. Todavia, o conhecimento epidemiológico em torno da COVID-19 no município tem ocorrido, sobretudo, através de documentos institucionais das Secretarias de Saúde. Desse modo, a finalidade deste estudo é fornecer evidências que permitam ampliar a compreensão da ocorrência da doença em nível local, ofertar dados e informações que venham a subsidiar as políticas públicas de saúde municipais e gerar hipóteses sobre a morbimortalidade da doença para futuras investigações científicas. Objetivo: Analisar o perfil epidemiológico dos casos internados e confirmados de COVID-19 no município de Mossoró no estado do Rio Grande do Norte/Brasil. Metodologia: Estudo observacional transversal, baseado em dados secundários de casos internados de COVID-19 registrados no Sistema Único de Saúde entre março e outubro de 2020.Resultados:Foram incluídos na amostra 664 pacientes, dos quais 46,5% evoluíram para óbito. Entre as internações, 63,1% resultaram em internações em unidades de terapia intensiva. Observamos diferenças estatísticas significativas entre 'admissão na unidade de terapia intensiva e evolução para óbito' e 'faixa etária e evolução para óbito' e, maior risco entre idosos acima de 60 anos, com comorbidades, dispneia e saturação de O2 <95%. A necessidade de suporte ventilatório invasivo foi considerada fator predisponente para óbito. O risco de internação na unidade de terapia intensiva foi maior entre as idosas. Conclusões: A hospitalização e o óbito de pacientes com COVID-19foram maiores em pacientes idosos com comorbidades (AU).


Introduction:As observed in the national scenario, the city of Mossoró showed high lethality rates in the first months of the pandemic. However, the epidemiological knowledge around COVID-19 in the municipality has occurred mostly through institutional documents from the Health Secretariats. Thus, the purpose of this study is to provide evidence to broaden the understanding of the occurrence of the disease at the local level, provide data and information that will support municipal health public policies and generate hypotheses about the morbidity and mortality of the disease for future scientific investigations. Objective: To analyze the epidemiological profile of hospitalized and confirmed cases of COVID-19 in the municipality of Mossoró in the state of Rio Grande do Norte/Brazil. Methodology:This is a cross-sectional and observational study, based on secondary data from the hospitalized COVID-19 cases recorded in the Unified Health System (Sistema Unificado de Saúde, SUS) between March and October 2020. Results:664 patients were included in the sample, of which 46.5% evolved to death. Among hospitalizations, 63.1% resulted in intensive care units admissions. We observed significant differences between intensive care unit admission and evolution to death' and 'age group and evolution to death' and, higher risk among elderly individuals over 60 years, with comorbidities, dyspnea and O2 saturation<95%. Need for invasive ventilatory support was considered a predisposing factor for death. The risk of intensive care unit admission was higher among eldery women.Conclusions:Hospitalization and death of patients with COVID-19 were higher in elderly patients with comorbidities (AU).


Introducción: Como se observó en el escenario nacional, el municipio de Mossoró presentó altas tasas de letalidad en los primeros meses de la pandemia. Sin embargo, el conocimiento epidemiológico en torno al COVID-19 en el municipio se ha dado principalmente a través dedocumentos institucionales de las Secretarías de Salud. Por lo tanto, el objetivo de este estudio es proporcionar evidencias para ampliar el conocimiento de la ocurrencia de la enfermedad en el ámbito local, proporcionar datos e informaciones que apoyen las políticas públicas municipales de salud y generar hipótesis sobre la morbilidad y mortalidad de la enfermedad para futuras investigaciones científicas. Objetivo: Analizar el perfil epidemiológico de los casos hospitalizados y confirmados de COVID-19 en el municipio de Mossoró en el estado de Rio Grande do Norte/Brasil.Metodología: Se trata de un estudio transversal y observacional, basado en datos secundarios de los casos hospitalizados de COVID-19 registrados en el Sistema Unificado de Salud (SUS) entre marzo y octubre de 2020. Resultados: La muestra incluyó 664 pacientes, de los cuales el 46,5% falleció. Entre los ingresos, el 63,1% resultaron en ingresos en la unidad de cuidados intensivos. Se observaron diferencias estadísticas significativas entre el "ingreso en la unidad de cuidados intensivos y la evolución hasta la muerte" y el "grupo de edad y la evolución hasta la muerte", y un mayor riesgo entre los pacientes mayores de 60 años, con comorbilidades, disnea y saturación de O2 <95%. La necesidad de soporte ventilatorio invasivo se consideró un factor predisponente para la muerte. El riesgo de ingreso en la unidad de cuidados intensivos fue mayor entre las mujeres de edad avanzada. Conclusiones: La hospitalización y la muerte de los pacientes con COVID-19 fueron mayores en los pacientes de edad avanzada con comorbilidades (AU).


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Health Profile , Pandemics/statistics & numerical data , COVID-19/transmission , Health Policy , Hospitalization/statistics & numerical data , Brazil/epidemiology , Chi-Square Distribution , Logistic Models , Indicators of Morbidity and Mortality , Cross-Sectional Studies/methods
3.
Bol. malariol. salud ambient ; 62(1): 8-15, jun, 2022. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1379267

ABSTRACT

Introducción: La malaria es una de las enfermedades infecciosas más importantes y para tratarla además de medicamentos, la población emplea plantas medicinales. El objetivo fue establecer los factores asociados a malaria y las plantas empleadas para su tratamiento en habitantes de Corozal. Método: Se aplicó una encuesta con preguntas sociodemográficas, de la vivienda, de conocimiento y de actitudes y las plantas medicinales empleadas para tratarla. Resultados: El 48% emplean plantas medicinales solas o con medicamentos, siendo el Gliricidia sepium (matarratón) y el Acmella oppositifolia (yuyo) las plantas más empleadas. En el 48% de las casas ha habido malaria. Por regresión logística se estableció que la malaria se asoció con conocer cómo se adquiere, consultar al médico tradicional y tener más de 15 años en Corozal. Conclusiones: Las plantas que la población de este estudio reportan no muestran evidencia científica como antimalaricos. Es importante una mayor presencia de las autoridades de salud y su trabajo conjunto con el médico tradicional para lograr estrategias más efectivas(AU)


Introduction: Malaria is one of the most important infectious disease and to treat it in addition to medicines the population uses medicinal plants. The objective was to establish the factors associated with malaria and the plants used for its treatment in inhabitants of Corozal. Method: A survey was applied with sociodemographic questions about housing, knowledge and attitudes, in addition to the medicinal plants used to treat it. Results: 48% use medicinal plants alone or with medicines, Gliricidia sepium (rat poisson) and Acmella oppositifolia (Opposite-leaf Spotflower) are the most used. In 48% of the homes there has been malaria. By logistic regression it was established that malaria was associated with knowing how it is acquired, consulting the traditional doctor and living in Corozal for more than 15 years. Conclusions: The plants that the population of this study report usimg do not show scientific evidence antimalarials. A greater presence of health authorities and their joint work with the traditional doctor for more effective strategies is important(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Plants, Medicinal , Health Knowledge, Attitudes, Practice , Malaria , Antimalarials/therapeutic use , Logistic Models , Colombia/epidemiology
4.
Bol. malariol. salud ambient ; 62(1): 32-38, jun, 2022. tab, ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1379293

ABSTRACT

Hay dos tipos principales de tejido adiposo; el subcutáneo, que es menos activo metabólicamente, y el tejido adiposo visceral, que secreta constantemente citocinas inflamatorias y está relacionado a enfermedades metabólicas y cardiovasculares. Nuestro objetivo fue identificar la asociación entre el exceso de grasa visceral y la severidad de enfermedad en pacientes con COVID-19. Se realizó un estudio observacional analítico que incluyó a pacientes con COVID-19 admitidos al Hospital Carrión de Huancayo, Perú. Se utilizó la balanza de bioimpedancia para cuantificar la composición corporal, la variable dependiente fue la severidad de enfermedad. Se utilizó el análisis de regresión logística para determinar la asociación de la grasa visceral y otros parámetros antropométricos con severidad de enfermedad. Se analizaron a 120 personas con COVID-19, la edad promedio fue 50 años, el sexo masculino fue 60%. De acuerdo a los valores de la composición corporal emitidos por el equipo de bioimpedancia: La grasa visceral > 15Kg (OR 7,31; p = 0,001); la grasa corporal total > 35% (OR 5,58; p = 0,009) y el exceso de peso > 20Kg (OR 6,96; p = 0,011) fueron los parámetros asociados a enfermedad severa por COVID-19. La relación positiva entre el perímetro abdominal y la cantidad de grasa visceral fue significativo (p = 0,01). En la composición corporal, el exceso de grasa visceral es el mayor parámetro asociado a enfermedad severa por COVID-19(AU)


There are two main types of adipose tissue; the subcutaneous, which is less metabolically active, and the visceral adipose tissue, which constantly secretes inflammatory cytokines and is related to metabolic and cardiovascular diseases. Our objetive was to identify the association between the excess of visceral fat and disease severity in COVID-19 patients. An analytical observational study was carried out which included patients with COVID-19 admitted to the Carrión Hospital in Huancayo, Peru. The bioimpedance balance was used to quantify the body composition; the dependent variable was the severity of the disease. A logistic regression analysis was used to determine the association of visceral fat and other anthropometric parameters with the severity of the disease. Out of 120 people with COVID-19 were analyzed, the average age was 50 years, the male sex was 60%. According to the body composition values issued by the bioimpedance team: Visceral fat> 15Kg (OR 7.31; p = 0.001); Total body fat> 35% (OR 5.58; p = 0.009) and excess weight> 20Kg (OR 6.96; p = 0.011) were the parameters associated with severe disease due to COVID-19. The positive relationship between abdominal circumference and the amount of visceral fat was significant (p = 0.01). In body composition, excess visceral fat is the main parameter associated with severe COVID-19 disease(AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Aged , Aged, 80 and over , Respiratory Distress Syndrome, Newborn/epidemiology , Intra-Abdominal Fat/physiopathology , COVID-19/physiopathology , COVID-19/epidemiology , Obesity/physiopathology , Peru/epidemiology , Severity of Illness Index , Body Mass Index , Logistic Models , Regression Analysis , Hospitals
5.
Rev. méd. hondur ; 90(1): 44-52, ene.-jun. 2022. tab.
Article in Spanish | LILACS, BIMENA | ID: biblio-1393228

ABSTRACT

La pandemia de la COVID-19 continúa reportando casos y fallecimientos a nivel mundial y nacional. La vacuna contra COVID-19, ha logrado contener la propagación de la enfermedad, sin embargo, todavía no tiene una aceptación total. Objetivo: Determinar el nivel de conocimiento, actitudes y aceptabilidad de la vacuna contra la COVID-19 y factores asociados, en estudiantes de la Universidad Nacional Autónoma de Honduras (UNAH) en año 2021. Métodos: Estudio observacional, transversal, descriptivo con análisis de asociación. La población de estudio fueron los estudiantes de la UNAH. Resultados: Un total de 1,417 estudiantes participaron, de los cuales el 52.3% (741) no estaban vacunados contra la COVID-19. Se encontró que el 93.5% (693/741) aceptaría aplicarse la vacuna. Se realizó una regresión logística binaria múltiple reportando que, el grupo de edad de 40 a 44 años tendrían mayor posibilidad de no aceptabilidad de la vacuna (OR=17, IC95% 2.462-120.661; p=0.004). Con respecto a los factores psicosociales se encontró que, la norma subjetiva y el control conductual inadecuado conllevaría a mayor posibilidad de no aceptación de la vacuna. (OR=11.4, IC95% 3.605- 36.664; p=0.000) y (OR=4.6, IC95% 1.678-12.281; p=0.003), respectivamente. Finalmente, la actitud social y la percepción de riesgo inadecuado implicaría no aceptar la vacuna (OR=13, IC95% 5.683-30.322; p=0.000) y (OR=6, IC95% 2.189- 15.159; p=0.000), respectivamente. Discusión: Según los resultados de este estudio, los estudiantes que no aceptaron vacunarse tuvieron influencia en su entorno familiar, social y de su propia capacidad para decidir, sumado a una percepción de riesgo inadecuada por una influencia directa en los mismos...(AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , COVID-19 Vaccines/immunology , COVID-19/prevention & control , Students , Logistic Models
6.
Int. j. morphol ; 40(3): 774-780, jun. 2022. ilus, tab
Article in English | LILACS-Express | LILACS | ID: biblio-1385678

ABSTRACT

SUMMARY: The aim of this study is to contribute to sex determination studies from the scapula in the Turkish population and compare with previous studies. This study was performed with 200 scapulae (100 males and 100 females). The age range of the patients was between 18-93 years old. Computed tomography scans were used and length of glenoid cavity (LGC), breadth of glenoid cavity (BGC), depth of glenoid cavity (DGC), perimeter (PM) and volume (VL) were measured. Randomly selected 20 scapulae were measured three times for examine the intra-rater reliability from those measurements. Gender logistic regression analysis was conducted to find the significant variables at sex determination from the scapula. The most effective parameter in determining sex from scapula was found to be VL (88.5%). The effects of LGC, PM, BGC and DGC at sex determination from scapula were found to be 83%, 82.5%, 79.5%, 66%, respectively. The combination of VL and PM (89.5%) was found to be the most effective combination at sex determination from the scapula. The intraclass correlation values of all measurements were found to be at high reliability. According to the literature, PM and DGC along with the VL in Turkish population, were not used previously for sex determination from the scapula. A combination of the VL and PM was found to be the most effective parameters at sex determination from scapula in the Turkish population. There are few studies on the sex determination from scapula in the Turkish population. This study will guide anthropologists, forensic scientists and anatomists at sex determination studies from scapula and surgeons by morphometrically in clinical situations related to the scapula.


RESUMEN: El objetivo de este estudio fue contribuir a la determinación del sexo a partir de la escápula en la población turca y comparar con estudios previos. Esta investigación se realizó con 200 escápulas (100 hombres y 100 mujeres). El rango de edad de los pacientes estaba entre de 18 años y 93 años. Escaner de tomografía computada se usó para medir en la cavidad glenoidea los siguientes parámetros: longitud (LCG), ancho (ACG), profundidad (PCG), perímetro (PG) y volumen (VCG). Se midieron 20 escápulas seleccionadas tres veces al azar para examinar la confiabilidad intraevaluador de estas mediciones. Se realizó un análisis de regresión logística de género para encontrar las variables significativas en la determinación del sexo a partir de la escápula. El parámetro más eficaz para determinar el sexo a partir de la escápula resultó ser VCG (88,5%). Los efectos de LCG, PG, ACG y PCG en la determinación del sexo a partir de la escápula fueron del 83 %, 82,5 %, 79,5 % y 66 %, respectivamente. La combinación de VCG y PG (89,5%) resultó ser la combinación más efectiva en la determinación del sexo a partir de la escápula. Se encontró que los valores de correlación intraclase de todas las mediciones tenían una alta confiabilidad. De acuerdo con la literatura, PG y PCG junto con el VCG en la población turca, no se han utilizado previamente para la determinación del sexo a partir de la escápula. Se determinó que una combinación de VCG y PG son los parámetros más efectivos en la determinación del sexo a partir de la escápula. Existe escasa información sobre la determinación del sexo a partir de la escápula en la población turca. Este estudio guiará a los antropólogos, forenses y anatomistas en los estudios de determinación del sexo de la escápula y sera útil para los cirujanos en situaciones clínicas relacionadas con la escápula.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Tomography, X-Ray Computed , Sex Determination by Skeleton , Glenoid Cavity/anatomy & histology , Glenoid Cavity/diagnostic imaging , Scapula/anatomy & histology , Scapula/diagnostic imaging , Turkey , Logistic Models
7.
J. bras. psiquiatr ; 71(2): 83-91, abr.-jun. 2022. tab
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1386078

ABSTRACT

OBJETIVO: O objetivo deste estudo foi avaliar a prevalência de comportamento suicida (ideação, plano e tentativa) nos últimos 12 meses e ao longo da vida e fatores associados entre alunos de Medicina da Universidade Federal do Rio de Janeiro (UFRJ). MÉTODOS: Um estudo seccional foi desenvolvido em uma amostra representativa e aleatória (n = 324) de 1.217 estudantes de Medicina da UFRJ entre abril e novembro de 2019. Os dados foram coletados por cinco pesquisadores em uma entrevista presencial com 296 alunos (taxa de participação de 91,4%), usando um questionário do Estudo Multicêntrico de Intervenção no Comportamento Suicida para avaliar o comportamento suicida, o PHQ-9 (Questionário de Saúde do Paciente-9) para avaliar o episódio depressivo maior e o ASSIST (Teste de Triagem do Envolvimento com Substâncias) para aferir o uso e abuso de substâncias. Para a avaliação das associações, utilizou-se o modelo de regressão logística. RESULTADOS: As prevalências nos últimos 12 meses foram de 18,9% (IC de 95%: 14,9-23,8) para ideação, 6,1% (IC de 95%: 3,9-9,4) para plano e 1,7% (IC de 95%: 0,7- 4,1) para tentativa de suicídio. As prevalências ao longo da vida foram de 27,7% (IC de 95%: 22,9-33,0) para ideação, 12,5% (IC de 95%: 9,2-16,7) para plano e 5,7% (IC de 95%: 3,6-9,0) para tentativa de suicídio. Os resultados encontrados foram maiores que os achados dos estudos nacionais. O episódio depressivo maior e o tratamento psicológico atual foram associados ao comportamento suicida na análise final. CONCLUSÕES: A associação com tratamento em saúde mental e episódio depressivo maior sugere que as universidades deveriam implementar programas para a prevenção do comportamento suicida.


OBJECTIVE: The aim of this paper is to analyze the lifetime and past 12-month prevalence rates of suicidal behavior (suicidal ideation, suicide plans and suicidal attempt) and associated factors among medical students at the Federal University of Rio de Janeiro. METHODS: Sectional study was applied to a representative and random set (n = 324) of 1,217 medical students between April and November of 2019. The data were collected by five researchers through in-person interviews with 296 of 324 volunteers (participation rate of 91.4%), using the Multisite Intervention Study on Suicidal Behavior interview to assess suicidal behavior, the PHQ-9 (Patient Health Questionnaire-9) to assess major depressive episode, and ASSIST (Alcohol, Smoking and Substance Involvement Screening Test) to assess substance use and abuse. A logistic regression model was used to calculate associations. RESULTS: The rates of past-12 month were found to be 18.9% (CI 95%: 14.9-23.8) for ideation, 6.1% (CI 95%: 3.9-9.4) for suicide plans and 1.7% (CI 95%: 0.7-4.1) for suicidal attempts. The lifetime prevalence rates were 27.7% (CI 95%: 22,9-33,0) for suicidal ideation, 12.5% (CI 95%: 9.2-16.7) for plans and 5.7% (CI 95%: 3.6-9.0) for suicidal attempts. These rates are higher than the measured results among medical students in Brazil. The factors associated in the final analysis were the major depressive episode and current psychological treatment. CONCLUSIONS: The association between mental health treatment and major depressive episode suggest that the universities should implement suicidal behavior prevention programs.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Students, Medical/psychology , Suicide, Attempted/statistics & numerical data , Suicidal Ideation , Logistic Models , Prevalence , Surveys and Questionnaires , Risk Factors , Depressive Disorder, Major/epidemiology , Sociodemographic Factors
8.
ABCS health sci ; 47: e022204, 06 abr. 2022. ilus, tab
Article in English | LILACS | ID: biblio-1363533

ABSTRACT

INTRODUCTION: Kidney transplantation (KT) is the renal replacement therapy (RRT) of choice for patients with chronic kidney disease (CKD). However, not every KT is successful and some patients persist on RRT. OBJECTIVE: To model a logistic regression with pre- and post-KT risk covariates capable of predicting secondary allograft dysfunction in need of RRT or reaching stage V of CKD until the first six months post-KT. METHODS: Cohort with KT recipients from Northeastern Brazil. Medical records of KT performed between 2011-2018 were analyzed. KT-recipients with insufficient data or who abandoned follow-up were excluded. The covariables analyzed were: demographic; infectious; pre- and post-KT comorbidities; panel reactive-antibodies; number of HLA mismatches; acute rejection episodes mediated by T-cell (ACR) or antibodies (AAR) six months after KT; and laboratory tests six months after KT. RESULTS: Covariates with higher risk for the analyzed outcomes six months after KT were: elderly KT recipients (OR:1.41; CI95%:1.01-1.99), time between onset of RRT and KT (ΔT-RRT&KT)>10years (OR:3.54; CI95%:1.27-9.87), diabetes mellitus (DM) pre-KT (OR:3.35; CI95%:1.51-7.46), pyelonephritis (OR:2.45; CI95%:1.24-4.84), polyomavirus nephropathy (OR:4.99; CI95%:1.87-13.3), AAS (OR:4.82; CI95%:1.35-17.2), 24h-proteinuria ≥300mg/24h (OR:5.05; CI95%:2.00-12.7) and serum calcium (Ca) <8.5mg/dL (OR:4.72; CI95%:2.00-11.1). The multivariate model presented an accuracy of 88.1% and the mean variance inflation factor is 1.81. CONCLUSION: Elderly-recipients, ΔT-RRT&KT>10 years, pre-KT DM, and post-KT aggressions until six months (pyelonephritis, polyomavirus nephropathy, ABMR, 24h-proteinuria≥300mg/24h, and Ca<8.5mg/dL) are associated with high predictive power for secondary allograft dysfunction in need of RRT or reaching CKD stage V until the first six months post-KT.


INTRODUÇÃO: Transplante renal (TR) é a terapia renal substitutiva (TRS) de escolha para pacientes com doença renal crônica (DRC). Entretanto, nem todo TR é bem-sucedido e alguns pacientes persistem em TRS. OBJETIVO: Modelar uma regressão logística com covariáveis de risco pré e pós-TR preditora da disfunção secundária do aloenxerto com necessidade de TRS ou alcance ao estágio V da DRC até os primeiros seis meses pós-TR. MÉTODOS: Coorte com receptores transplantados realizado em hospital no Nordeste brasileiro. Analisou-se registros médicos dos TR realizados entre 2011-2018. Receptores com dados insuficientes ou que abandonaram seguimento foram excluídos. Foram analisadas covariáveis: demográficas; infecciosas; comorbidades pré e pós-TR; painel de reatividade; incompatibilidades de HLA; episódios de rejeições agudas mediadas por células-T ou por anticorpos; exames laboratoriais seis meses pós-TR. RESULTADOS: Receptores idosos (OR:1,41; IC95%:1,01-1,99), tempo entre início da TRS e TR (∆T-TRS&TR)>10 anos (OR:3,54; IC95%:1,27-9,87), diabetes mellitus (DM) pré-TR (OR:3,35; IC95%:1,51-7,46), pielonefrite (OR:2,45; IC95%:1,24-4,84), nefropatia por poliomavírus (OR:4,99; IC95%:1,87-13,3), RAMA (OR:4,82; IC95%:1,35-17,2), proteinúria de 24h (Pt24h) ≥300mg/24h (OR:5,05; IC95%:2,00-12,7) e cálcio sérico (Ca)<8,5mg/dL (OR:4,72; IC95%:2,00-11,1) foram identificadas como covariáveis de maior risco para os desfechos analisados até seis meses pós-TR. O modelo multivariado apresentou acurácia de 88,1% e fator de inflação da variância médio de 1,81. CONCLUSÃO: Receptores idosos, ∆T-TRS&TR>10anos, DM pré-TR e agressões até seis meses pós-TR (pielonefrite, nefropatia por poliomavírus, RAMA, Pt24h≥300mg/24h e Ca<8,5mg/dL), apresentam alto poder preditivo para disfunção secundária do aloenxerto com necessidade de TRS ou alcance ao estágio V da DRC até os primeiros seis meses pós-TR.


Subject(s)
Humans , Male , Female , Risk Factors , Kidney Transplantation , Renal Insufficiency, Chronic , Allografts , Proteinuria , Pyelonephritis , Logistic Models , Retrospective Studies , Renal Dialysis , Immunosuppression Therapy , BK Virus , Disease Progression , Hypocalcemia
9.
Int. j. cardiovasc. sci. (Impr.) ; 35(2): 230-242, Mar.-Apr. 2022. tab, graf
Article in English | LILACS | ID: biblio-1364972

ABSTRACT

Abstract Background Cardiovascular diseases (CVDs) are the main cause of morbidity and mortality in Brazil. Objective To provide population-based data on prevalence and factors associated with CVD risk factors. Methods Individuals aged ≥20 years from two editions of the cross-sectional Health Survey of São Paulo focusing on Nutrition (ISA-Nutrition), performed in Sao Paulo city in 2008 (n=590) and 2015 (n=610), were evaluated for: obesity, central obesity, waist/height ratio, high blood pressure (HBP), dyslipidemia, diabetes, and number of CVD risk factors ≥3. Prevalence was estimated according to complex survey procedures. Factors associated with cardiovascular risk factors were assessed using logistic regression, with statistical significance of p<0.05. Results Obesity and older age were associated with higher odds of all cardiovascular risk factors investigated, except for dyslipidemia. HBP was positively associated with being Black/Brown and negatively associated with being physicaly active in leisure time. Women were more likely to have increased adiposity indicators and three or more cardiovascular risk factors than men. Those with higher education had lower chances of having diabetes, HBP and dyslipidemia, and those with higher income had higher chances of having three or more risk factors. Former smokers had higher odds of diabetes, obesity, and high waist/height ratio, and smokers had higher odds of high non-HDL cholesterol levels. From 2008 to 2015, there was an increase (p<0.001) in the prevalence of diabetes (6.9% to 17.3%), HBP (31.9% to 41.8%), dyslipidemia (51.3% to 67.6%), and number of CVD risk factors ≥3 (18.9% to 34.1%). Conclusion This study shows increasing prevalence of CVD risk factors in adult population in Sao Paulo and may support the definition of target groups and priority actions on CVD prevention and treatment.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Young Adult , Cardiovascular Diseases/epidemiology , Cardiometabolic Risk Factors , Brazil , Logistic Models , Odds Ratio , Prevalence , Cross-Sectional Studies , Health Surveys , Morbidity , Age Factors , Diabetes Mellitus/epidemiology , Age and Sex Distribution , Dyslipidemias/epidemiology , Waist-Height Ratio , Hypertension/epidemiology , Obesity/epidemiology
10.
Actual. SIDA. infectol ; 30(108): 7-16, 20220000. graf, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1363203

ABSTRACT

Las infecciones de piel y partes blandas (IPPB) en niños son una de las principales causas de prescripción de antimicrobianos. El objetivo del estudio fue describir las características clínicas y microbiológicas de las IPPB ambulatorias de niños asistidos en dos hospitales zonales. Se realizó un estudio prospectivo entre el 1/11/2017 y el 1/11/2018. Se incluyeron pacientes entre 1 mes y 15 años internados en dos hospitales. Se evaluó: edad, sexo, localidad, factores predisponentes, tipo de IPPB, muestras biológicas realizadas, aislamiento microbiológico, tratamiento empírico indicado y evolución del cuadro. Se realizó antibiograma y determinación genética. Se calculó chi2, IC95, OR; α=5%. N= 94. 58,7% masculinos. 12 pacientes <1 año, 85 >1 año (promedio de edad 4 años, 1-15). El 36% de Tandil y 63,8% de Florencio Varela. El 59,6% corresponden a IPPB purulentas. Se aislaron microorganismos en un 59,6%. Los aislamientos principales: SAMR (40,4%), SAMS (7,4%), S. agalactiae (2,1%) y S. pyogenes (2,1%). El 100% de SAMR son portadores de gen mecA y SCCmec tipo IV, sin multirresistencia. No hubo diferencia estadística entre los factores de riesgo evaluados para el desarrollo de IPPB por SAMR. El 52,1% de los niños recibió tratamiento antibiótico combinado, siendo la más indicada TMS-SMX + CLI en 36 eventos. (38,3%). La evolución fue favorable: no hubo diferencia significativa entre el subgrupo que se aisló SAMR y el que no se aisló SAMR; 91,9% (34/37) y 92,6% (50/54) correspondientemente (chi2: 0,01; p= 0,97 IC95: 0,26-3,88). El principal agente etiológico fue SAMRco, debiendo adecuar los tratamientos a este microorganismo.


Skin and soft tissue infections (SSIs) in children are one of the main causes of antimicrobial prescription. The aim of the study was to describe the clinical and microbiological characteristics of outpatient SSIs in children attended in two hospitals. A prospective study was conducted between 11/1/2017 and 11/1/2018. Patients between 1 month and 15 years old, hospitalized were included. We evaluated: age, sex, locality, predisposing factors, type of IPPB, biological samples taken, microbiological isolation, empirical treatment indicated and evolution of the condition. An antibiogram and genetic determination were performed. Chi2, CI95, OR; α=5% were calculated. N= 94. 58.7% male. 12 patients <1 year, 85 >1 year (mean age 4 years, 1-15). 36% were from Tandil and 63.8% from Florencio Varela. 59.6% corresponded to purulent SSIs. The diagnostic yield was 59.6%. Main isolates: MRSA (40.4%), MSSA (7.4%), S. agalactiae (2.1%) and S. pyogenes (2.1%). 100% of MRSA carried the mecA gene and SCCmec type IV, with no multidrug resistance. There was no statistical difference between the risk factors evaluated. 52.1% of children received combined antibiotic treatment, the most indicated being TMS-SMX + CLI in 36 events. (38,3%). Evolution was favorable: there was no significant difference between the subgroup that isolated MRSA and the subgroup that did not isolate MRSA; 91.9% (34/37) and 92.6% (50/54) respectively (chi2: 0.01; p= 0.97 CI95: 0.26-3.88). The main etiological agent was MRSA, and treatments should be adapted to this microorganism


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Skin Diseases, Infectious/microbiology , Staphylococcal Infections/microbiology , Staphylococcus aureus/isolation & purification , Soft Tissue Infections/microbiology , Skin Diseases, Infectious/drug therapy , Staphylococcus aureus/genetics , Logistic Models , Prospective Studies , Risk Factors , Soft Tissue Infections/drug therapy , Drug Therapy, Combination , Methicillin-Resistant Staphylococcus aureus/isolation & purification , Methicillin-Resistant Staphylococcus aureus/genetics , Anti-Bacterial Agents/therapeutic use
11.
Rev. ABENO ; 22(2): 1563, jan. 2022. tab
Article in English | LILACS, BBO | ID: biblio-1391323

ABSTRACT

This study aimed to measure the levels of depression, anxiety and stress among dental students during the COVID-19 pandemic and distance learning.This cross-sectional questionnaire-based survey was conducted at a Brazilian school of Dentistry, between July and August, 2020. The participants were surveyed using the adapted and validated version of Depression, Anxiety, and Stress Scale (DASS-21) questionnaire. The Fisher's exact test and bivariate logistic regression analysis were performed to analyze the data, using SPSS software. A total of 120 dental students (response rate of 87.60%) participated in the study; 75.8% of them were female and the mean age was 23.35 years old (± 6.07). Most students were single (85%), studied full time (68.3%) and had no employment (70.8%). Some level of depression, anxiety and stress was observed in 64.2%, 67.5% and 61.7% of the students, respectively. The severity of the depression, the anxiety and the stress was significantly associated (p < 0.05) with the student's gender, fear of contracting COVID-19 and with thecondition of having a family member who has already had COVID-19. Female students, students who were fear of contracting COVID-19 and who had a familiar or a friend diagnosed with COVID-19 presented more chances of developing a high level of depression, anxiety or stress.We concluded thatdental students had high levels of depression, anxiety and stress during the COVID-19 pandemic and distance learning. This study suggests that the mental health of dental students should be carefully monitored during theCOVID-19 pandemic (AU).


Este estudo teve como objetivo mensurar os níveis de depressão, ansiedade e estresse entre estudantes de Odontologia durante a pandemia da COVID-19 e o ensino à distância. Esta pesquisa transversal, realizada por meio de um questionário on-line, foi realizada em uma Faculdade de Odontologia do Brasil, entre julho e agosto de 2020. Os participantes foram avaliados por meio da versão adaptada e validada do questionário Escala de Depressão, Ansiedade e Estresse (DASS-21). Para análise dos dados foram realizados o Teste Exato de Fisher e a Análise de Regressão Logística Bivariada, por meio do software SPSS. Participaram do estudo 120 estudantes de odontologia (taxa de resposta de 87.60%). Destes, 75.8% deles eram do sexo feminino e a média de idade foi de 23,35 anos (± 6,07). A maioria dos alunos era solteira (85,0%), estudava em tempo integral (68,3%) e não tinha vínculo empregatício (70,8%). Algum nível de depressão, ansiedade e estresse foi observado em 64,2%, 67,5% e 61,7% dos alunos, respectivamente. As gravidades da depressão, da ansiedade e do estresse estiveram significativamente associadas (p <0.05) ao sexo do aluno, ao medo de contrair a COVID-19 e à condição de ter um membro da família que já teve a COVID-19. Estudantes do sexo feminino, estudantes com medo de contrair a COVID-19 e que tiveram um familiar ou amigo com diagnóstico de COVID-19 apresentaram maiores chances de desenvolver um alto nível de depressão, ansiedade ou estresse. Concluímos que os estudantes de odontologia apresentaram altos níveis de depressão, ansiedade e estresse durante a pandemia da COVID-19 e o ensino à distância. Este estudo sugere que a saúde mental dos estudantes de odontologia deve ser monitorada cuidadosamente durante a pandemia da COVID-19 (AU).


Subject(s)
Humans , Male , Female , Adolescent , Adult , Stress, Psychological/psychology , Students, Dental/psychology , Mental Health , Education, Distance/methods , COVID-19/transmission , Logistic Models , Cross-Sectional Studies/methods , Surveys and Questionnaires
12.
Rev. ABENO ; 22(2): 1741, jan. 2022. tab
Article in English | LILACS, BBO | ID: biblio-1396725

ABSTRACT

The aim this study was to evaluate the association between the use of dental services and the sociodemographic characteristics and perceptions of oral health of pregnant women living in amunicipality of southern Brazil. The instrument used in this cross-sectional study was a questionnaire composed of questions about sociodemographic characteristics, perceptions of oral health and access to dental services, administered to 102 pregnant women during prenatal care. Descriptive analyses of the variables were performed, along with multivariate analyses for the estimation in a logistic regression model. The mean age of the women was 29±6.2 years. The area of residence, first pregnancy, and the perception that pregnancy impairs oral health and causes weakening of teeth remained significant predictors of dental consultation. The chances of not having had a dental appointment were significantly higher for pregnant women who lived in the countryside, by more than three times; those who believed that pregnancy damages teeth, more than five times; and those teeth were weakened during this period, more than eight times. Furthermore, not being the first pregnancy was a protective factor for not having dental appointment.Women who are pregnant for the first time, living in rural areas and with misperceptions about dental conditions during pregnancy, did not consult during pregnancy (AU).


O objetivo do estudo foi avaliar a associação entre a utilização de serviços odontológicos e as características sociodemográficas e percepções sobre saúde bucal de gestantes residentes em um município do Sul do Brasil. O instrumento utilizado no estudo transversal foi um questionário composto por questões sobre características sociodemográficas, percepções de saúde bucal e acesso a serviços odontológicos, aplicado a 102 gestantes durante o pré-natal. Foram realizadas análises descritivas multivariadas das variáveis em modelo de regressão logística. A média de idade das mulheres foi de 29±6,2 anos. A zona de residência, a primeira gravidez e a percepção de que a gravidez prejudica a saúde bucal e causa enfraquecimento dos dentes permaneceram como preditores significativos da consulta odontológica. As chances de não ter feito consulta odontológica foram significativamente maiores para as gestantes residentes na zona rural em mais de três vezes; as que acreditavam que a gravidez danifica os dentes em mais de cinco vezes; e que os dentes enfraqueceram nesse período mais de oito vezes. Além disso, não ser a primeira gravidez foi fator de proteção para a consulta odontológica. Mulheres grávidas pela primeira vez, residentes na zona rural e com percepções equivocadas sobre as condições odontológicas durante a gestação, não utilizaram o serviço odontológico durante a gestação (AU).


Subject(s)
Humans , Male , Female , Pregnancy , Adolescent , Adult , Middle Aged , Prenatal Care , Oral Health , Dental Care , Pregnant Women , Social Perception , Logistic Models , Rural Areas , Cross-Sectional Studies/methods , Multivariate Analysis , Surveys and Questionnaires
13.
Cad. Saúde Pública (Online) ; 38(6): e00290321, 2022. tab
Article in English | LILACS | ID: biblio-1374852

ABSTRACT

Despite the drastic decrease in the incidence of Chagas disease in Brazil, past cases still greatly impact health services in the country. Thus, this study aimed to characterize Chagas disease cases regarding their cardiac staging and death prognosis and, based on that, to propose primary healthcare (PHC) case follow-ups. This is a cross-sectional study based on secondary data from the medical records of patients with chronic Chagas cardiomyopathy (CCC). A logistic regression was applied to estimate crude and adjusted odds ratios (OR). A total of 433 medical records were evaluated. More severe CCC cases were associated with a greater number of hospitalizations (OR = 3.41; 95%CI: 1.59-7.30) and longer hospitalization (OR = 3.15; 95%CI: 1.79-5.53). Cases with a higher risk of death were associated with a higher number of hospitalizations (OR = 1.92; 95%CI: 1.09-3.37), longer hospital stays (OR = 2.04; 95%CI: 1.30-3.18), and visits to the outpatient clinic (OR = 2.18; 95%CI: 1.39-3.41) and the emergency department of the assessed hospital (OR = 3.12; 95%CI: 1.27-7.66). Analyzing the medical records at two moments, 72.9% of the cases remained in the stages in which they were initially evaluated. Overall, 44.4% of cases were classified as mild to moderate risk of death and 68.3% as low ones. The cases classified in the most severe stages of CCC and with high or intermediate risk of death were associated with greater hospital dependence. However, most cases were classified as milder forms of the disease, with a low risk of death and clinical stability. These findings aim to promote the role of PHC as a protagonist in the longitudinal follow-up of CCC cases in Brazil.


Apesar da diminuição importante na incidência da doença de Chagas no Brasil, as infecções ocorridas no passado ainda têm um impacto grande sobre os serviços de saúde no país. Portanto, o estudo buscou caracterizar os casos de doença de Chagas quanto ao estadiamento cardíaco e prognóstico de morte, e com base nisso, propor o seguimento dos casos na atenção primária à saúde (APS). O estudo transversal usou dados secundários dos prontuários de pacientes com cardiomiopatia chagásica crônica (CCC). Foi aplicada a regressão logística para estimar os odds ratios (OR) brutos e ajustados. Foram avaliados 433 prontuários médicos. Casos mais graves de CCC estavam associados com número maior de hospitalizações (OR = 3,41; IC95%: 1,59-7,30) e tempo de internação (OR = 3,15; IC95%: 1,79-5,53). Os casos com risco maior de morte estavam associados com número maior de hospitalizações (OR = 1,92; IC95%: 1,09-3,37), tempo de internação (OR = 2,04; IC95%: 1,30-3,18) e visitas aos ambulatórios (OR = 2,18; IC95%: 1,39-3,41) e serviços de emergência (OR = 3,12; IC95%: 1,27-7,66). Ao analisar os prontuários em dois momentos, 72,9% dos casos permaneceram nos estágios inicialmente avaliados. No total, 44,4% dos casos foram classificados como formas leves a moderadas e 68,3% como risco baixo de morte. Os casos classificados nos estágios mais graves de CCC e com risco de morte alto ou intermediário estavam associados com maior dependência hospitalar. Entretanto, a maioria dos casos foram classificados como formas mais leves da doença, clinicamente estáveis e com baixo risco de morte. Os achados apoiam a promoção do papel da APS como protagonista no seguimento longitudinal dos casos de CCC no Brasil.


A pesar de la drástica disminución de la incidencia de la enfermedad de Chagas en Brasil, los casos infectados en el pasado siguen teniendo un gran impacto en los servicios de salud del país. Por lo tanto, este estudio tuvo como objetivo caracterizar los casos de enfermedad de Chagas en lo que se refiere al estadio cardíaco y al pronóstico de muerte y, con base en eso, proponer el seguimiento de los casos por parte de la atención primaria de salud (APS). Se trata de un estudio transversal basado en datos secundarios de las historias clínicas de los pacientes con miocardiopatía chagásica crónica (MCC). Se aplicó la regresión logística para estimar las odds ratio (OR) crudas y ajustadas. Se evaluaron 433 historias clínicas. Los casos de MCC más graves se asociaron a un mayor número de hospitalizaciones (OR = 3,41; IC95%: 1,59-7,30) y días de hospitalización (OR = 3,15; IC95%: 1,79-5,53). Los casos con mayor riesgo de muerte se asociaron a un mayor número de hospitalizaciones (OR = 1,92; IC95%: 1,09-3,37), días de hospitalización (OR = 2,04; IC95%: 1,30-3,18), y las visitas a los ambulatorios (OR = 2,18; IC95%: 1,39-3,41) y al servicio de urgencias (OR = 3,12; IC95%: 1,27-7,66). Analizando las historias clínicas en dos momentos, el 72,9% de los casos permanecieron en los estadios en los que fueron evaluados inicialmente. En general, el 44,4% de los casos fueron clasificados como formas leves o moderadas y el 68,3% como de bajo riesgo de muerte. Los casos clasificados en los estadios más graves de la MCC y con riesgo de muerte alto o intermedio se asociaron a una mayor dependencia hospitalaria. Sin embargo, la mayoría de los casos fueron clasificados como formas más leves de la enfermedad, con bajo riesgo de muerte y clínicamente estables. Estos resultados pretenden promover el papel de la APS como protagonista en el seguimiento longitudinal de los casos de MCC en Brasil.


Subject(s)
Humans , Chagas Cardiomyopathy/epidemiology , Chagas Disease/epidemiology , Primary Health Care , Brazil/epidemiology , Logistic Models , Cross-Sectional Studies
14.
Article in English | LILACS, INDEXPSI | ID: biblio-1394492

ABSTRACT

Abstract Item Response Theory represents one of the major advances in the field of developing valid and reliable measures in psychology. Among the main models used in this perspective are the Rasch model and the logistic models. These parametric models, however, are not suitable for all applications in psychology, since a substantial number of databases in psychology do not satisfy the assumptions of these models: unidimensionality; latent monotonicity; local independence; and, for some models, non-intersecting functions. Given this framework, the objective of this study was to present the theoretical and practical foundations of Mokken Scale Analysis (MSA). We present some historical issues involving the development of MSA, in addition to the main characteristics and assumptions of the two models used in this perspective. After exemplifying a MSA application, limitations and final considerations are presented, supporting the decision-making process for researchers who come to use MSA.


Resumo A Teoria de Resposta ao Item representa um dos principais avanços para a construção de medidas válidas e confiáveis em psicologia. Entre os principais modelos utilizados nessa perspectiva estão o modelo de Rasch e os modelos logísticos. Esses modelos paramétricos, no entanto, não podem ser utilizados em todas as aplicações em psicologia, uma vez que um número substancial dos bancos de dados em psicologia não satisfaz os pressupostos desses modelos: unidimensionalidade; monotonicidade latente; independência local; e, para alguns modelos, não-interseção de funções. Dessa forma, o objetivo deste estudo foi apresentar os fundamentos teóricos e práticos da Análise de Escala de Mokken (AEM). São apresentadas questões históricas envolvendo o desenvolvimento da AEM, além das principais características e pressupostos dos dois modelos usados nessa perspectiva. Após exemplificação de uma AEM, limitações e considerações finais são apresentadas, apoiando o processo de tomada decisão para pesquisadores que venham a usar a AEM.


Resumen La Teoría de Respuesta al Ítem representa uno de los mayores avances en el campo del desarrollo de medidas válidas en psicología. Entre los principales modelos utilizados en esta perspectiva se encuentran los modelos logísticos. Estos modelos no son adecuados para todas las aplicaciones en psicología, ya que algunas bases de datos en psicología no satisfacen las suposiciones de estos modelos: unidimensionalidad; monotonicidad latente; e independencia local; y, para algunos modelos, funciones que no se interceptan. Teniendo en cuenta este marco, el objetivo de este estudio fue presentar los fundamentos teóricos y prácticos del Análisis de la Escala de Mokken (AEM). Presentamos algunas cuestiones históricas relacionadas con el desarrollo de AEM, además de las principales características y suposiciones de los dos modelos utilizados en esta perspectiva. Después de ejemplificar un AEM, se presentan las limitaciones y consideraciones finales, apoyando o procesando la tomada de decisión para investigadores que van a usar el AEM.


Subject(s)
Weights and Measures , Logistic Models , Statistics, Nonparametric
15.
Article in English | LILACS, BBO | ID: biblio-1386799

ABSTRACT

Abstract Objective: To evaluate the barriers to access and oral health care faced by children and adolescents with Cerebral Palsy (CP) according to their motor impairment through the perception of caregivers. Material and Methods: A case series study was carried out at three health institutions in Pernambuco, Brazil. The study sample consisted of 94 caregivers of 5-to-18-year-old patients with CP, according to GMFCS (The Gross Motor Function Classification System). Data were collected using a semi-structured form to evaluate the barriers to access and analyzed statistically by the chi-square and Fisher exact tests, adopting a 5% level of significance. In addition, binary logistic regression was performed to determine the weight of the variables in explaining the outcome variable. Results: There were major difficulties involving transportation (p=0.04) and structural accessibility to dental services (p<0.01) among children and adolescents with severe CP. In addition, the more severe the CP, the greater the difficulty of accessibility (OR=4.09,) and the lower the income (OR=8.80), the greater the motor impairment. Conclusion: Despite the availability of access to dental services, low-income families have more severe CP patients, contributing to the daily difficulties already faced by them in oral health care.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Social Perception , Cerebral Palsy/pathology , Oral Health , Caregivers , Dental Care for Disabled , Epidemiologic Studies , Logistic Models , Surveys and Questionnaires , Statistics, Nonparametric , Disabled Children , Observational Studies as Topic
16.
Pesqui. bras. odontopediatria clín. integr ; 22: e200246, 2022. tab, graf
Article in English | LILACS, BBO | ID: biblio-1386808

ABSTRACT

Abstract Objective: To assess the influence of the COVID-19 pandemic on levels of anxiety, stress, and orofacial pain in individuals with and without TMD. Material and Methods: In this cross-sectional study, the participants were divided into two groups (n=10, each) experimental group (EG) TMD patients and control group (CG), without TMD. The presence of TMD was confirmed using the RDC/TMD. The Beck Anxiety Scale (BAI), Perceived Stress Scale (PSS), and Oral Analog Scale were used for assessment. The Beck Anxiety Scale is composed of 21 multiple-choice questions describing symptoms of anxiety, while the PSS is a measure that evaluates life situations as stressful. An Oral Analogue Scale was applied to each individual to quantify orofacial pain, with 0 (zero) without pain and 10 (ten) being the worst pain ever felt. The comparison between groups was performed using the Mann-Whitney test. Logistic regression was used to verify TMD dependence in relation to BAI and PSS-10. Quantitative variables were correlated with each other by Pearson's correlation coefficient. The level of significance considered for all tests was 5%. Results: The association was statistically significant (p≤0.05) for BAI and PSS with a TMD. Conclusion: Although the COVID 19 pandemic has had a psychological impact on the general population, patients with TMD have higher levels of anxiety and stress than the control group.


Subject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Aged , Anxiety/psychology , Stress, Psychological/psychology , Temporomandibular Joint Disorders/pathology , Risk Factors , COVID-19/transmission , Social Isolation/psychology , Logistic Models , Cross-Sectional Studies/methods , Surveys and Questionnaires , Statistics, Nonparametric
17.
Article in Chinese | WPRIM | ID: wpr-940988

ABSTRACT

OBJECTIVE@#To select variables related to mortality risk of stroke patients in intensive care unit (ICU) through long short-term memory (LSTM) with attention mechanisms and Logistic regression with L1 norm, and to construct mortality risk prediction model based on conventional Logistic regression with important variables selected from the two models and to evaluate the model performance.@*METHODS@#Medical Information Mart for Intensive Care (MIMIC)-Ⅳ database was retrospectively analyzed and the patients who were primarily diagnosed with stroke were selected as study population. The outcome was defined as whether the patient died in hospital after admission. Candidate predictors included demogra-phic information, complications, laboratory tests and vital signs in the initial 48 h after ICU admission. The data were randomly divided into a training set and a test set for ten times at a ratio of 8 ∶2. In training sets, LSTM with attention mechanisms and Logistic regression with L1 norm were constructed to select important variables. In the test sets, the mean importance of variables of ten times was used as a reference to pick out the top 10 variables in each of the two models, and then these variables were included in conventional Logistic regression to build the final prediction model. Model evaluation was based on the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy. And the model performance was compared with the forward Logistic regression model which hadn't conducted variable selection previously.@*RESULTS@#A total of 2 755 patients with 2 979 ICU admission records were included in the analysis, of which 526 recorded deaths. The AUC of Logistic regression model with L1 norm was statistically better than that of LSTM with attention mechanisms (0.819±0.031 vs. 0.760±0.018, P < 0.001). Age, blood glucose, and blood urea nitrogen were at the top ten important variables in both of the two models. AUC, sensitivity, specificity, and accuracy of Logistic regression models were 0.85, 85.98%, 71.74% and 74.26%, respectively. And the final prediction model was superior to forward Logistic regression model.@*CONCLUSION@#The variables selected by Logistic regression with L1 norm and LSTM with attention mechanisms had good prediction performance, which showed important implications on the mortality prediction of stroke patients in ICU.


Subject(s)
Critical Care , Humans , Intensive Care Units , Logistic Models , Memory, Short-Term , Prognosis , ROC Curve , Retrospective Studies , Stroke
18.
Article in Chinese | WPRIM | ID: wpr-935755

ABSTRACT

Objective: To understand the relationship between female breast cancer and occupational risk factors in Beijing, and provide scientific basis for the formulation of prevention strategies and measures. Methods: From June to December 2019, A 1: 1 case-control study was adopted, eight medical institutions in Beijing were selected as the research objects. Patients with breast cancer diagnosed by medical institutions were selected as case group and non breast cancer patients in the same medical institution as control group. A total of 973 subjects were included, including 495 in the case group and 478 in the control group. A one-to-one survey was conducted using a questionnaire uniformly compiled by the Beijing Centers for Disease Control and Prevention. The survey content mainly includes basic demographic characteristics and occupational risk factors. The Trait Coping Style Questionnaire (TCSQ) was used to investigate the corresponding methods, including two aspects: positive coping and negative coping. First, chi square test or Wilcoxon rank sum test were used for univariate analysis. Then Lasso regression was used to screen the risk factors of breast cancer. Finally, the risk factors were screened by multivariate logistic regression analysis. Results: Education lovel was 49.64%, body mass index (BMI) was 18.4~23.9 kg/m(2), accounting for 48.82%, marital status ws 84.48%. Compared with no night shift history, there was a significant increase in risk of breast cancer at night shift history (OR=1.70, 95% CI: 1.25~2.30, P<0.05) . Compared with most of the sitting posture and sometimes standing, the risk of breast cancer was increased, and the difference was statistically significant (OR=2.01, 95%CI: 1.40~2.90, P<0.05) . Conclusion: In the occupation risk factors, night shift work and working posture are related to the incidence of breast cancer in women, establishing a good schedule and avoiding long standing can effectively prevent and reduce the occurrence of breast cancer.


Subject(s)
Beijing , Breast Neoplasms/epidemiology , Case-Control Studies , Female , Humans , Logistic Models , Risk Factors
19.
Article in Chinese | WPRIM | ID: wpr-935354

ABSTRACT

Objective: To investigate the influencing factors of HBV intrauterine transmission and their interaction effects by integrating logistic regression model and Chi-squared automatic interaction detector (CHAID) decision tree model. Methods: A total of 689 pairs of HBsAg-positive mothers and their neonates in the obstetrics department of the Third People's Hospital of Taiyuan from 2007 to 2013 were enrolled, and the basic information of mothers and their neonates were obtained by questionnaire survey and medical record review, such as the general demographic characteristics, gestational week and delivery mode. HBV DNA and HBV serological markers of the mothers and newborns were detected by fluorescence quantitative PCR and electrochemiluminescence immunoassay respectively. The CHAID decision tree model and unconditional logistic regression analysis were used to explore the factors influencing HBV intrauterine transmission in neonates of HBsAg-positive mothers. Results: Among the 689 neonates, the incidence of HBV intrauterine transmission was 11.47% (79/689). After adjusted for confounding factors, the first and second logistic multivariate analysis showed that cesarean delivery was a protective factor for HBV intrauterine transmission (OR=0.25, 95%CI: 0.14-0.43; OR=0.27, 95%CI: 0.15-0.46); both models indicated that maternal HBeAg positivity and HBV DNA load ≥2×105 IU/ml before delivery were risk factors of HBV intrauterine transmission (OR=3.89, 95%CI: 2.32-6.51; OR=3.48, 95%CI: 2.12-5.71), respectively. The CHAID decision tree model screened three significant factors influencing HBV intrauterine transmission, the most significant one was maternal HBeAg status, followed by delivery mode and maternal HBV DNA load. There were interactions between maternal HBeAg status and delivery modes, as well as delivery mode and maternal HBV DNA load before delivery. The rate of HBV intrauterine transmission in newborns of HBeAg-positive mothers by vaginal delivery increased from 19.08% to 29.37%; among HBeAg-positive mothers with HBV DNA ≥2×105 IU/ml, the rate of HBV intrauterine transmission increased to 33.33% in the newborns by vaginal delivery. Conclusions: Maternal HBeAg positivity,maternal HBV DNA ≥2×105 IU/ml and vaginal delivery could be risk factors for HBV intrauterine transmission in newborns. Interaction effects were found between maternal HBeAg positivity and vaginal delivery, as well as vaginal delivery and high maternal HBV DNA load. Logistic regression model and the CHAID decision tree model can be used in conjunction to identify the high-risk populations and develop preventive strategies accurately.


Subject(s)
DNA, Viral/genetics , Decision Trees , Female , Hepatitis B Surface Antigens , Hepatitis B e Antigens , Hepatitis B virus/genetics , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical , Logistic Models , Mothers , Pregnancy , Pregnancy Complications, Infectious/epidemiology
20.
Article in Chinese | WPRIM | ID: wpr-935348

ABSTRACT

Objective: To analyze the migration of the HIV/AIDS cases and related factors in Liangshan Yi autonomous prefecture (Liangshan). Methods: According to HIV/AIDS Comprehensive Response Information Management System of China Information System for Disease Control and Prevention, a total of 28 772 HIV/AIDS cases who had follow-up records in Liangshan in 2020 were included in the survey. The migration of the HIV/AIDS cases was described and the related factors were analyzed using multiple logistic regression models, and the migration destinations of the HIV/AIDS cases were mapped. Results: Among the 28 772 HIV/AIDS cases, 20.89% (6 010/28 772) had migration in 2020. Multivariate logistic regression analysis showed that among the HIV/AIDS cases, the migration related factors included being aged 15-24 years (compared with being aged 0-14 years, OR=2.74, 95%CI:2.04-3.69) and ethnic group (compared with Han ethnic group, OR=2.44, 95%CI:2.19-2.72), having education level of junior high school (compared with having education level of primary school or below, OR=1.25, 95%CI:1.14-1.38), being unmarried (compared with being married, OR=1.29, 95%CI:1.20-1.39), being engaged in business services (compared with being engaged in farming, OR=1.96, 95%CI:1.31-2.92), receiving antiviral treatment <1 year (compared with receiving antiviral treatment >3 years, OR=1.42, 95%CI:1.26-1.61), having recent CD4+T lymphocytes (CD4) counts >500 cells/μl (compared with having recent CD4 counts <200 cells/μl, OR=1.15, 95%CI:1.03-1.29). The geographical distribution maps showed that among all cities in Sichuan, Xichang (13.26%, 797/6 010) and Chengdu (10.12%,608/6 010) were the main migration destinations of the HIV/AIDS cases, and the provinces outside Sichuan where the HIV/AIDS cases would like to migrate to were mainly Guangdong (18.19%, 1 093/6 010) and Zhejiang provinces (7.67%, 461/6 010) in 2020. The HIV/AIDS cases who migrated where Liangshan, within Sichuan province, and to other provinces accounted for 27.67% (1 663/6 010), 15.34% (922/6 010) and 56.99% (3 425/6 010), respectively. Conclusions: More attention should be paid to the mobility characteristics and the classification management of HIV/AIDS cases according to their characteristics in Liangshan. Timely access to information on changes in the place of work and residence of HIV/AIDS cases should be warranted when they have migration. Good referrals and management for mobility of HIV/AIDS cases in different places should be made to reduce loss to follow-up and improving interventions.


Subject(s)
Acquired Immunodeficiency Syndrome/epidemiology , Adolescent , Adult , Child , Child, Preschool , China/epidemiology , Ethnicity , HIV Infections/epidemiology , Humans , Infant , Infant, Newborn , Logistic Models , Marriage , Young Adult
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