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Rev. Hosp. Clin. Univ. Chile ; 33(1): 51-62, 2022. tab, ilus
Article in Spanish | LILACS | ID: biblio-1401534


Patients with SARS-Cov-2 infection and lung cancer have an unfavorable prognosis, characterized by higher rates of respiratory failure, use of invasive mechanical ventilation and higher mortality rates. Due to similarities in affected organs in Covid-19 and lung cancer, the radiological accurate diagnosis has become a challenge for physicians. Radiologic findings of lung cancer, such as parenchymal consolidation, spiculation and microlobulations are not specific. Imaging findings of Covid-19 in patients with lung cancer consist of multiple patchy multifocal bilateral ground-glass opacities and consolidations, being hardly distinguishable from an underlying lung malignancy. Differential radiological diagnosis in patients with lung cancer and Covid-19 must include pneumonitis and lung toxicity caused by chemotherapy, target therapies and radiotherapy. Follow-up and simulation tomography in radiotherapy have become an unexpected ally in the early detection of Covid-19 in asymptomatic stages in lung cancer patients. Patients with lung cancer should have particular considerations due to their high risk and the adverse effects of systemic therapies and radiotherapy. (AU)

Humans , Male , Female , COVID-19/diagnostic imaging , Lung Neoplasms/diagnostic imaging , COVID-19/complications , COVID-19/radiotherapy , Lung Neoplasms/complications , Lung Neoplasms/radiotherapy
Chinese Journal of Lung Cancer ; (12): 272-277, 2022.
Article in Chinese | WPRIM | ID: wpr-928802


In recent years, with the widespread use of immunodepressant agents, Pneumocystis jirovecii pneumonia (PJP) has been significantly found in non-human immunodeficiency virus (HIV) patients, such as those with malignancies, post-transplantation and autoimmune diseases. Although the risk factors and management of PJP have been extensively studied in the hematologic tumor and post-transplant populations, the research on real tumor cases is insufficient. Lung cancer has been the most common tumor with the highest number of incidence and death worldwide, and the prognosis of lung cancer patients infected with PJP is poor in clinical practice. By reviewing the previous studies, this paper summarized the epidemiology and clinical manifestations of PJP in lung cancer patients, the risk factors and possible mechanisms of PJP infection in lung cancer patients, diagnosis and prevention, and other research progresses to provide reference for clinical application.

Humans , Incidence , Lung Neoplasms/complications , Pneumocystis carinii , Pneumonia, Pneumocystis/diagnosis , Risk Factors
Rev. medica electron ; 43(1): 2942-2953,
Article in Spanish | LILACS, CUMED | ID: biblio-1156786


RESUMEN La COVID 19 es una enfermedad pandémica producida por el virus SARS-CoV-2, tiene dentro de los grupos vulnerables al cáncer de pulmón por presentar una inmunodepresión adquirida por los tratamientos oncoespecíficos administrados y esto conlleva a una mayor exposición a complicaciones si se contrae esta terrible infección que azota al mundo en la actualidad. El objetivo fue exponer los riesgos y complicaciones que tienen los pacientes con cáncer de pulmón que reciben tratamientos oncoespecíficos si se infectan con el SARS-COV-2. Se realizó una revisión sistemática de los principales artículos publicados en inglés y en español por autores cubanos y extranjeros en revistas de alto impacto a nivel mundial, información reportada por la Organización Mundial de la Salud, la red de Infomed y el Ministerio de Salud Pública de Cuba. Se concluyó que los pacientes con cáncer de pulmón no presentan un riesgo superior a la población general para contraer la COVID 19, sí existe cierta evidencia de que estos pacientes puedan sufrir una infección más grave si la adquieren (AU).

SUMMARY COVID-19 is a pandemic disease produced by SARS-CoV-2 virus; the group of patients with lung cancer is vulnerable to this disease because of presenting an acquired immune depression due to administered oncospecific treatments, leading to higher exposition to complications if the patient gets this terrible disease striking worldwide nowadays. The objective of this review was exposing the risk and complications affronted by patients suffering lung cancer with oncospecific treatment if they get infected by SARS-CoV-2. The authors carried out a systematic review of the main articles published in Spanish and English by Cuban and foreign authors in high impact journals around the world, information reported by the World Health Organization, INFOMED and the Ministry of Public Health of Cuba. It was concluded that patients with lung cancer are not at a higher risk of catching COVID-19 than general population; it does exist certain evidence of that these patients could suffer a more serious infection if they get the disease (AU).

Humans , Risk Factors , Coronavirus Infections/etiology , Immune System/physiopathology , Lung Neoplasms/complications , Coronavirus Infections/diagnosis , Database , Drug Therapy , Immunotherapy , Lung Neoplasms/drug therapy
Article in Chinese | WPRIM | ID: wpr-878712


Remitting seronegative symmetrical synovitis with pitting edema(RS3PE),the inflammatory arthritis attacking mainly elderly males,is characterized by symmetrical synovitis with pitting edema of the dorsum of hands and feet and the absence of rheumatoid factor.RS3PE commonly accompanies malignant tumor,infections and other diseases.Here we report a case of RS3PE associated with lung malignancy and review other six cases to summarize the clinical features,treatment and prognosis.

Aged , Edema/etiology , Humans , Lung Neoplasms/complications , Male , Syndrome , Synovitis/drug therapy
Rev. bras. cir. cardiovasc ; 35(5): 841-843, Sept.-Oct. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1137322


Abstract Cardiac rhythm disorders are common in many patients with cancer. The management of synchronous long-standing persistent atrial fibrillation and pulmonary lesions remains a serious surgical dilemma due to the lack of clinical data and surgical guidelines. To the best of our knowledge, this is the first described case of simultaneous thoracoscopic pulmonary segmentectomy and left atrial posterior wall and pulmonary vein isolation combined with left atrial appendage resection in a patient with early-stage primary lung cancer and long-standing persistent atrial fibrillation.

Humans , Female , Aged , Atrial Fibrillation/surgery , Atrial Fibrillation/complications , Catheter Ablation/methods , Adenocarcinoma, Mucinous/surgery , Adenocarcinoma, Mucinous/complications , Adenocarcinoma, Mucinous/diagnostic imaging , Pneumonectomy/methods , Pulmonary Veins/surgery , Thoracoscopy , Tomography, X-Ray Computed , Treatment Outcome , Atrial Appendage/surgery , Heart Atria/surgery , Lung Neoplasms/surgery , Lung Neoplasms/complications , Lung Neoplasms/diagnostic imaging
An. bras. dermatol ; 95(1): 67-70, Jan.-Feb. 2020. graf
Article in English | LILACS | ID: biblio-1088720


Abstract Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. We here describe the case of a 70-year-old man who presented with asthenia, weight loss, dry cough and total body erythema with desquamation over the past month. A chest computed tomography scan showed a nodular lesion, which was finally diagnosed as a squamous cell lung carcinoma. To our knowledge, as an erythroderma presentation, only 13 cases have been reported in the literature. This case report demonstrates the need to search for a neoplasm in patients presenting with erythroderma, particularly in the presence of accompanying debilitating symptoms.

Humans , Male , Aged , Dermatitis, Exfoliative/pathology , Neoplasms, Squamous Cell/pathology , Lung Neoplasms/pathology , Paraneoplastic Syndromes/pathology , Biopsy , Tomography, X-Ray Computed , Dermatitis, Exfoliative/etiology , Neoplasms, Squamous Cell/complications , Erythema/pathology , Lung Neoplasms/complications
Clinics ; 75: e2060, 2020. tab
Article in English | LILACS | ID: biblio-1133346


New cases of the novel coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continue to rise worldwide following the declaration of a pandemic by the World Health Organization (WHO). The current pandemic has completely altered the workflow of health services worldwide. However, even during this critical period, patients with other diseases, like cancer, need to be properly treated. A few reports have shown that mortality due to SARS-CoV-2 is higher in elderly patients and those with other active comorbidities, including cancer. Patients with lung cancer are at risk of pulmonary complications from COVID-19, and as such, the risk/benefit ratio of local and systemic anticancer treatment has to be considered. For each patient, several factors, including age, comorbidities, and immunosuppression, as well as the number of hospital visits for treatment, can influence this risk. The number of cases is rising exponentially in Brazil, and it is important to consider the local characteristics when approaching the pandemic. In this regard, the Brazilian Thoracic Oncology Group has developed recommendations to guide decisions in lung cancer treatment during the SARS-CoV-2 pandemic. Due to the scarcity of relevant data, discussions based on disease stage, evaluation of surgical treatment, radiotherapy techniques, systemic therapy, follow-up, and supportive care were carried out, and specific suggestions issued. All recommendations seek to reduce contagion risk by decreasing the number of medical visits and hospitalization, and in the case of immunosuppression, by adapting treatment schemes when possible. This statement should be adjusted according to the reality of each service, and can be revised as new data become available.

Humans , Aged , Pneumonia, Viral/prevention & control , Coronavirus Infections/prevention & control , Coronavirus , Pandemics/prevention & control , Patient Care/standards , Lung Neoplasms/therapy , Pneumonia, Viral/transmission , Pneumonia, Viral/epidemiology , Pneumonia, Viral/virology , Societies, Medical , Brazil , Practice Guidelines as Topic , Coronavirus Infections/transmission , Coronavirus Infections/epidemiology , Coronavirus Infections/virology , Resource Allocation/economics , Resource Allocation/organization & administration , Betacoronavirus , SARS-CoV-2 , COVID-19 , Lung Neoplasms/complications
Medicina (B.Aires) ; 79(5): 411-414, oct. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1056742


El hipertiroidismo es una condición relativamente frecuente con múltiples etiologías. La más común es la enfermedad de Graves, seguida del bocio multinodular y el adenoma tóxico. La asociación entre hipertiroidismo y cáncer es infrecuente en la práctica clínica. Presentamos el caso de un varón de 42 años con síntomas de hipertiroidismo de dos meses de evolución. Al examen físico se constató una marcada hepatomegalia de consistencia duro pétrea. El examen de testículos se reveló normal. Se llevó a cabo el diagnóstico de hipertiroidismo a través del dosaje hormonal. Los estudios por imágenes mostraron la presencia de múltiples lesiones sólidas compatibles con metástasis hepáticas. Luego de descartar las causas habituales de hipertiroidismo y las neoplasias primarias de la glándula tiroides, se consideró la posibilidad de mimetismo molecular a través de la producción ectópica de gonadotrofina coriónica humana. Se obtuvieron valores críticamente elevados de esta hormona y en un segundo tiempo se confirmó el diagnóstico histológico de coriocarcinoma a través de una biopsia hepática. Consideramos que el reconocimiento de este mecanismo poco frecuente de hipertiroidismo, puede ser una clave diagnóstica para arribar rápidamente al diagnóstico correcto, particularmente en los tumores extragonadales.

Hyperthyroidism is a relatively frequent condition with multiple causes. The most common cause is Graves' disease; followed by hyperthyroid multinodular goiter and toxic adenoma. Association between hyperthyroidism and cancer is infrequent in daily practice. We present the case of a 42-year-old man who developed severe symptoms of hyperthyroidism within a period of two months. Physical examination revealed significant hepatomegaly. Testicular examination proved normal. Imaging studies showed the presence of multiple hepatic solid lesions consistent with metastases. After discarding the most common causes of hyperthyroidism and primary thyroid gland neoplasm, the possibility of molecular mimicry was considered through human chorionic gonadotrophin production. Critical high values of this hormone were found and choriocarcinoma histological diagnosis was confirmed through a liver biopsy. We consider that the recognition of this rare mechanism of hyperthyroidism may be a clue permitting a faster diagnosis, particularly when extragonadal tumors are present.

Humans , Male , Adult , Choriocarcinoma, Non-gestational/complications , Hyperthyroidism/etiology , Brain Neoplasms/complications , Brain Neoplasms/pathology , Thyrotropin/blood , Tomography, X-Ray Computed , Fatal Outcome , Choriocarcinoma, Non-gestational/pathology , Chorionic Gonadotropin/blood , Hyperthyroidism/pathology , Liver Neoplasms/complications , Liver Neoplasms/pathology , Lung Neoplasms/complications , Lung Neoplasms/pathology
Autops. Case Rep ; 9(3): e2019110, July-Sept. 2019. tab, ilus
Article in English | LILACS | ID: biblio-1017374


Undifferentiated pleomorphic sarcoma (UPS) is a high-grade pleomorphic neoplasm with no identifiable line(s) of differentiation using currently available diagnostic techniques. Therefore, it is essentially a diagnosis of exclusion, which requires generous tissue sampling, adequate contextually interpreted immunohistochemistry, and relevant molecular studies. UPS is a common soft tissue sarcoma (historically one of the entities referred to as malignant fibrous histiocytoma (MFH)), which can develop in various organs, but lung involvement is usually due to metastasis. Primary Pulmonary UPS (PPUPS) is exceptionally rare and here we present a 66-year-old man who presented with anemia and weight loss, found to have a 17 cm right lung mass with invasion to the chest wall and diaphragm. Extensive sampling and immunohistochemistry studies failed to reveal any line of differentiation. Upon exclusion of a possible extrapulmonary origin, a diagnosis of PPUPS was rendered. In addition, we reviewed all 84 previously reported cases of PPUPS/PPMFH in the literature since 1979 and summarized the clinical information.

Humans , Male , Aged , Sarcoma/complications , Lung Neoplasms/complications , Soft Tissue Neoplasms
Salud pública Méx ; 61(3): 286-291, may.-jun. 2019. tab
Article in English | LILACS | ID: biblio-1094466


Abstract: Objective: To describe the epidemiological studies about the relationship between lung cancer (LC) and pulmonary tuberculosis (Tb) and its possible molecular mechanisms. Materials and methods: We reviewed research databases in search of publications that included keywords LC and Tb. Results: It has been proposed that chronic inflammation in the lungs due to Tb could cause clastogenic activity in the DNA of bronchial epithelium. Another possibility is lateral gene transfer; since Mycobacterium tuberculosis (MTb) is an intracellular organism, bacterial DNA could integrate to bronchial epithelial cells inducing neoplastic transformation. Conclusions: There are epidemiological reports, particularly from Asian countries, which confirm a relationship between LC and Tb. MTb could play an active role in cellular transformation and it is important to elucidate the mechanism involved.

Resumen: Objetivo: Describir los estudios que documentan la relación entre el cáncer de pulmón (CP) y la tuberculosis pulmonar (Tb) y sus posibles mecanismos moleculares. Material y métodos: Se revisaron bases de datos de publicaciones, usando como palabras clave CP y Tb. Resultados: Se ha propuesto que la inflamación crónica en el pulmón provocada por la Tb podría producir actividad clastogénica. Otra posibilidad es la transferencia lateral de genes; Mycobacterium tuberculosis (MTb) es un organismo intracelular facultativo cuyo DNA podría integrarse al material genético del epitelio bronquial induciendo transformación neoplásica. Conclusión: Existen evidencias epidemiológicas, particularmente en países asiáticos, que documentan la relación entre CP y Tb. MTb podría desempeñar un papel activo en la transformación neoplásica cuyo mecanismo debe de ser elucidado.

Humans , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/epidemiology , Lung Neoplasms/complications , Lung Neoplasms/epidemiology
Arch. endocrinol. metab. (Online) ; 63(2): 175-181, Mar.-Apr. 2019. tab, graf
Article in English | LILACS | ID: biblio-1001221


SUMMARY Cushing's syndrome (CS) is an uncommon condition that leads to high morbidity and mortality. The majority of endogenous CS is caused by excessive ACTH secretion, mainly due to a pituitary tumor - the so-called Cushing's disease (CD) - followed by ectopic ACTH syndrome (EAS), an extra-pituitary tumor that produces ACTH; adrenal causes of CS are even rarer. Several methods are used to differentiate the two main etiologies: specific laboratory tests and imaging procedures, and bilateral inferior petrosal sinus sampling (BIPSS) for ACTH determination; however, identification of the source of ACTH overproduction is often a challenge. We report the case of a 28-year-old woman with clinical and laboratory findings consistent with ACTH-dependent CS. All tests were mostly definite, but several confounding factors provoked an extended delay in identifying the origin of ACTH secretion, prompting a worsening of her clinical condition, with difficulty controlling hyperglycemia, hypokalemia, and hypertension. During this period, clinical treatment was decisive, and measurement of morning salivary cortisol was a differential for monitoring cortisol levels. This report shows that clinical reasoning, experience and use of recent methods of nuclear medicine were decisive for the elucidation of the case.

Humans , Female , Adult , ACTH Syndrome, Ectopic/diagnosis , Carcinoma, Neuroendocrine/diagnostic imaging , Lung Neoplasms/diagnostic imaging , Saliva/metabolism , ACTH Syndrome, Ectopic/etiology , Hydrocortisone/blood , Petrosal Sinus Sampling , Carcinoma, Neuroendocrine/complications , Carcinoma, Neuroendocrine/diagnosis , Adrenocorticotropic Hormone/blood , Diagnosis, Differential , Positron Emission Tomography Computed Tomography , Lung Neoplasms/complications , Lung Neoplasms/diagnosis
Rev. chil. enferm. respir ; 35(1): 58-62, mar. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1003647


Introducción: La linfangioleiomiomatosis Pulmonar (LAM) es una rara y progresiva enfermedad; caracterizada por proliferación excesiva de células musculares lisas a partir de vasos linfáticos, sanguíneos y vías aéreas. En conjunto al anormal crecimiento celular descrito, se aprecia degeneración quística difusa del parénquima pulmonar, lo que puede reflejarse desde cuadros completamente asintomáticos hasta el deterioro severo del intercambio gaseoso con insuficiencia respiratoria fulminante. Descripción del caso: Paciente femenino de 41 años de edad, con cuadro clínico consistente en tos seca ocasional, asociada a dolor leve de características pleuríticas en 'puntada de costado ' derecha. Ante la no mejoría clínica, se indica estudio imagenológico donde se demuestra neumotorax espontáneo derecho. En estudio tomográfico se aprecian además lesiones pulmonares quísticas. El estudio anátomo-patológico demuestra cambios estructurales que se reportan compatibles con LAM. Conclusión: Dada la simplicidad de los síntomas con que la LAM puede debutar, su confirmación diagnóstica se genera en fases avanzadas de la enfermedad, cuando el daño pulmonar importante conlleva a la aparición de factores clínicos con mayor repercusión sobre el estado general de los pacientes por lo que la realización de estudios imagenológicos tempranos gana vital importancia.

Introduction: Pulmonary lymphangioleiomyomatosis (LAM) is a rare and progressive disease; characterized by airway, lymphatic and blood vessels-smooth muscle cells excessive proliferation. Added to the abnormal cell growth, parenchymal cystic degeneration is present, which can be reflected initially as a asymptomatic course and can progress to severe gaseous exchange deterioration and fulminating respiratory insufficiency. Case description: A 41-year-old female patient with a clinical course consisting of occasional dry cough, associated with mild pleuritic pain on the right side of thorax. As no improvement was achieved, thoracic imaging study was performed, where a right pneumothorax was found. Tomography images showed multiple lung cystic lesions. Anatomopathological study reports structural changes compatible with LAM. Conclusion: Given the simplicity of the symptoms that LAM can debut with, its diagnostic confirmation is generated in advanced stages of the disease, when the important pulmonary damage leads to the appearance of clinical factors with greater impact on the general state of patients so early thoracic imaging studies gain vital importance.

Humans , Female , Adult , Lymphangioleiomyomatosis/diagnosis , Lymphangioleiomyomatosis/therapy , Lung Neoplasms/diagnosis , Lung Neoplasms/therapy , Pneumothorax/etiology , Spirometry , Radiography, Thoracic , Tomography, X-Ray Computed , Lymphangioleiomyomatosis/complications , Sirolimus/therapeutic use , Cysts/etiology , Lung Neoplasms/complications
Säo Paulo med. j ; 137(1): 100-103, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-1004736


ABSTRACT CONTEXT: Non-islet-cell-tumor-induced hypoglycemia (NICTH) is caused on rare occasions by secretion of insulin from tumor cells that are reported to have a single tissue origin. CASE REPORT: A 67-year-old male patient had cardia adenocarcinoma and concomitant lung adenocarcinoma with extensive metastases and repeated episodes of intractable hypoglycemia. Immunohistochemical staining for insulin showed that lung adenocarcinoma stained positive and gastric cardia adenocarcinoma stained weakly positive. These results indicate that tumor cells of different tissue origins co-secreted insulin. CONCLUSIONS: This is the first report on intractable hypoglycemia due to co-secretion of insulin from two kinds of primary tumor cells in a single patient.

Humans , Male , Aged , Stomach Neoplasms/complications , Cardia , Adenocarcinoma/complications , Hypoglycemia/etiology , Lung Neoplasms/complications , Stomach Neoplasms/diagnosis , Immunohistochemistry , Adenocarcinoma/diagnosis , Fatal Outcome , Positron Emission Tomography Computed Tomography , Lung Neoplasms/diagnosis
Rev. medica electron ; 41(1): 130-141, ene.-feb. 2019. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-991331


RESUMEN Introducción: en las últimas tres décadas, las enfermedades cardiovasculares y las neoplasias malignas han pasado a ser los principales problemas de salud en Cuba como consecuencia de la constante mejoría de los niveles de salud, la prevención de las enfermedades transmisibles, y el incremento de la esperanza de vida al nacer; entre ellas se destaca el cáncer de pulmón como el tumor primario que con mayor incidencia causa compromiso cerebral metastásico. Objetivo: analizar el comportamiento de las metástasis cerebrales en pacientes con cáncer de pulmón. Materiales y métodos: se realizó un estudio descriptivo y retrospectivo en 96 pacientes con diagnóstico cito-histológico de cáncer de pulmón y metástasis cerebral, atendidos en la consulta externa del Centro Oncológico Provincial de Matanzas, entre enero del 2013 y diciembre del 2016. Se obtuvieron los datos clínicos-demográficos a partir de las historias clínicas individuales de los enfermos y el documento de Reporte de Cáncer. Resultados: la mayor incidencia de cáncer de pulmón corresponde a las personas entre 45 y 64 años de edad; comportándose de forma similar para el género masculino como para el femenino, aunque el primero con un mayor número de casos y el color de la piel predominante para ambos sexos fue la blanca. En tanto las metástasis cerebrales son más comunes de la quinta a la séptima década de la vida. Conclusiones: la metástasis cerebral aparece desde edades tempranas hasta la tercera edad y el mayor porcentaje fue diagnosticado a inicio de la enfermedad constituyendo esto un factor de riesgo importante.

ABSTRACT Introduction: in the last three decades, cardiovascular diseases and malignant neoplasms have become the main health problem in Cuba as a consequence of the steady improvement of the health levels, the prevention of the communicable diseases, and the increase of the life expectancy at birth; among them lung cancer stands out as the primary tumor that more frequently causes metastatic brain compromise. Objective: to analyze the behavior of brain metastases in patients with lung cancer. Materials and methods: a retrospective and descriptive study was carried out in 96 patients with cyto-histological diagnosis of lung cancer and brain metastases, who attended the external consultation of the Provincial Oncologic Center of Matanzas, from January 2013 to December 2016. Clinic-demographic data were obtained from the patients´ individual clinical reports and the Cancer Report document. Results: the highest incidence of lung cancer corresponds to people aged 45-64 years; it behaves very similar both in male and in female genders, thought the first one shows more quantity of cases; white color skin predominated in both sexes. As for the brain metastases, they are more common from the fifth to the seventh decade of life. Conclusions: brain metastasis appears from early ages and up to the elder age; the highest percent was diagnosed at the beginning of the disease, being this an important risk factor.

Humans , Brain Neoplasms/etiology , Brain Neoplasms/epidemiology , Lung Neoplasms/complications , Lung Neoplasms/diagnosis , Lung Neoplasms/pathology , Lung Neoplasms/epidemiology , Neoplasm Metastasis , Survival Analysis , Epidemiology, Descriptive , Survival Rate , Retrospective Studies
An. bras. dermatol ; 93(6): 887-889, Nov.-Dec. 2018. graf
Article in English | LILACS | ID: biblio-973640


Abstract: Nodular vasculitis is an uncommon type of panniculitis. It was firstly associated to the infection by Mycobacterium tuberculosis and named erythema induratum of Bazin, however nowadays it has been associated with several other underlying disorders and it is better described as nodular vasculitis. Concerning its relationship with malignant conditions, there is only one reported case, in association with metastatic colon adenocarcinoma. We report a case of nodular vasculitis as the first manifestation of lung adenocarcinoma. To the best of our knowledge, this is the first reported association of both diseases.

Humans , Female , Middle Aged , Adenocarcinoma/complications , Erythema Induratum/etiology , Lung Neoplasms/complications , Adenocarcinoma/diagnosis , Erythema Induratum/pathology , Fatal Outcome , Lung Neoplasms/diagnosis
Rev. chil. cardiol ; 37(3): 201-205, dic. 2018. ilus
Article in Spanish | LILACS | ID: biblio-978001


Resumen: Se presenta el caso de un hombre de 61 años, portador de un cáncer pulmonar en quien lesiones de aspecto embólico llevan al diagnóstico de Endocarditis marántica (no infecciosa). Se describen las características clínicas del paciente, los métodos diagnósticos incluyendo imágenes ecocardiográficas y la confirmación necrópsica.

Abstracts: A 61-year-old male with skin lesions suggesting embolic phenomena, was thoroughly investigated and a final diagnosis of marantic (non-infectious) endocarditis was established. Clinical characteristics and diagnostic investigation through laboratory test and images sustained the diagnosis. The use of transesophageal echocardiography is emphasized. This was finally confirmed by findings at necropsy.

Humans , Male , Middle Aged , Adenocarcinoma, Papillary/complications , Endocarditis, Non-Infective/etiology , Endocarditis, Non-Infective/diagnostic imaging , Lung Neoplasms/complications , Magnetic Resonance Imaging , Adenocarcinoma, Papillary/diagnostic imaging , Tomography, X-Ray Computed , Fatal Outcome , Echocardiography, Transesophageal , Embolism/etiology , Lung Neoplasms/diagnostic imaging
Rev. bras. cir. cardiovasc ; 33(5): 483-489, Sept.-Oct. 2018. tab
Article in English | LILACS | ID: biblio-977450


Abstract Introduction: Optimal surgical approach for the treatment of resectable lung cancer accompanied by coronary artery disease (CAD) remains a contentious issue. In this study, we present our cases that were operated simultaneously for concurrent lung cancer and CAD. Methods: Simultaneous off-pump coronary artery bypass surgery (OPCABG) and lung resection were performed on 10 patients in our clinic due to lung cancer accompanied by CAD. Demographic features of patients, operation data and postoperative results were evaluated retrospectively. Results: Mean patient age was 63.3 years (range 55-74). All patients were male. Six cases of squamous cell carcinoma, three of adenocarcinoma and one case of large cell carcinoma were diagnosed. Six patients had single-vessel CAD and 4 had two-vessel CAD. Three patients underwent OPCABG at first and then lung resection. The types of resections were one right pneumonectomy, three right upper lobectomies, one right lower lobectomy, three left upper lobectomies, and two left lower lobectomies. Reoperation was performed in one patient due to hemorrhage. One patient developed intraoperative contralateral tension pneumothorax. One patient died due to acute respiratory distress syndrome at the early postoperative period. Conclusion: Simultaneous surgery is a safe and reliable option in the treatment of selected patients with concurrent CAD and operable lung cancer.

Humans , Male , Middle Aged , Aged , Pneumonectomy , Coronary Artery Disease/surgery , Coronary Artery Bypass, Off-Pump , Lung Neoplasms/surgery , Coronary Artery Disease/complications , Retrospective Studies , Treatment Outcome , Length of Stay , Lung Neoplasms/complications
Autops. Case Rep ; 8(3): e2018035, July-Sept. 2018. ilus
Article in English | LILACS | ID: biblio-911896


Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Its outcome may be poor or even fatal due to the high rate of recurrence and eventual spread to the entire respiratory tract. Pulmonary invasion is reported to occur in 3.3% of patients with RRP, and malignant transformation in 0.5% of patients. We report the case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation. Analysis of the papilloma and carcinomatous tissues revealed the presence of HPV type 11, which is associated with rapid and aggressive progression. We discussed the case on the basis of a literature review on pulmonary invasion, malignant transformation, and HPV 11 aggressiveness.

Humans , Female , Adult , Carcinoma, Squamous Cell/complications , Lung Neoplasms/complications , Papillomavirus Infections/complications , Autopsy , Carcinoma, Squamous Cell/pathology , Fatal Outcome , Human papillomavirus 11 , Papilloma/complications