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1.
Diagn. tratamento ; 26(2): 65-72, abr.-jun. 2021. tab, ilus
Article in Portuguese | LILACS | ID: biblio-1280726

ABSTRACT

O lúpus eritematoso é uma doença autoimune complexa que afeta diversos órgãos. A pele é o segundo local mais acometido e as manifestações cutâneas são divididas em específicas e não específicas. As primeiras possuem em comum o achado histopatológico de dermatite de interface com degeneração vacuolar da camada basal e infiltrado linfocitário na junção dermoepidérmica e são subdivididas em agudas, subagudas e crônicas. As manifestações não específicas compõem um grupo heterogêneo de condições que frequentemente está associado ao lúpus eritematoso sistêmico. O conhecimento e a interpretação adequada de tais manifestações é importante, pois, além da relevância diagnóstica, as lesões cutâneas nos dão informações prognósticas. Portanto, é imprescindível que o clínico conheça as principais manifestações cutâneas do lúpus eritematoso para a melhor condução desses pacientes.


Subject(s)
Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Discoid , Panniculitis, Lupus Erythematosus , Dermatology , Lupus Erythematosus, Systemic
2.
Rev. chil. reumatol ; 36(1): 24-30, 2020. tab, ilus
Article in Spanish | LILACS | ID: biblio-1282370

ABSTRACT

l lupus eritematoso es una afección que se conoce desde antiguo, referida en especial al compromiso cutáneo, pero ha sido mejor definida desde principios del siglo XIX, constituyéndose como una enfermedad sistémica con una base autoinmune. Mecanismos patogénicos inmunogenéticos desempeñan un papel en la susceptibilidad a la enfermedad, sobre la que actuarían variaciones hormonales y factores ambientales. De esta interacción deriva la producción de múltiples anormalidades inmunológicas, cuya acción sobre los tejidos da origen a la expresión clínica de la enfermedad. La relación entre el compromiso cutáneo, en especial crónico discoide, y sistémico, ha sido un factor de polémica, importante de dilucidar por el significado terapéutico y de pronóstico para el enfermo. De esta revisión se puede concluir que las diferentes manifestaciones del lupus constituyen una misma enfermedad, pero probablemente factores etiopatogénicos genéticos, hormonales y ambientales marcan la diferencia.


Lupus erythematosus is a condition that has been known since ancient times, especially referring to skin involvement, but has been better defined since the beginning of the 19th century, constituting itself as a systemic disease with an autoimmune basis. Immunogenetic pathogenic mechanisms play a role in disease susceptibility, on which hormonal variations and environmental factors would act. From this interaction derives the production of multiple immunological abnormalities, whose action on the tissues gives rise to the clinical expression of the disease. The relationship between cutaneous involvement, especially chronic discoid, and systemic, has been a controversial factor, important to elucidate due to its therapeutic and prognostic significance for the patient. From this review it can be concluded that the different manifestations of lupus constitute the same disease, but genetics, hormonal and environmental etiopathogenic factors probably make the difference.


Subject(s)
Humans , Lupus Erythematosus, Cutaneous/pathology , Lupus Erythematosus, Systemic , Lupus Erythematosus, Cutaneous/classification , Dermatitis/etiology
4.
Arq. bras. oftalmol ; 82(4): 345-353, July-Aug. 2019. graf
Article in English | LILACS | ID: biblio-1019411

ABSTRACT

ABSTRACT Cicatricial ectropion may be a consequence of certain systemic diseases as well as the result of drug use. Our goal here was to research the different causes of this condition as reported in the literature, including more recently suspected etiologies. A detailed PubMed literature search indicated many different etiologies were associated with cicatricial ectropion development, from severe cases of systemic diseases, such as ichthyosis and lupus erythematosus, to reversible scenarios secondary to anti-glaucomatous drug use. More recently reported connections include periorbital necrotizing fasciitis, frontal osteomyelitis, and antineoplastic agents. Indeed, cicatricial ectropion may be highly symptomatic; being able to determine its real etiology is imperative to managing patients properly. In this investigation, we felt that an explicitly multidisciplinary approach was essential, especially for cases associated with systemic conditions.


RESUMO O ectrópio cicatricial pode ser uma consequência de certas doenças sistêmicas, bem como o resultado do uso de drogas. Nosso objetivo aqui foi pesquisar as diferentes causas desta condição, conforme relatado na literatura, incluindo mais recentemente suspeitas de etiologias. Uma pesquisa bibliográfica detalhada do PubMed indicou que muitas etiologias diferentes estavam associadas ao desenvolvimento do ectrópio cicatricial, desde casos graves de doenças sistêmicas, como ictiose e lúpus eritematoso, até cenários reversíveis secundários ao uso de drogas antiglaucomatosas. Conexões relatadas mais recentemente incluem fasceíte necrosante periorbitária, osteomielite frontal e agentes antineoplásicos. De fato, o ectrópio cicatricial pode ser altamente sintomático; ser capaz de determinar sua etiologia real é imperativo para o manejo adequado dos pacientes. Nesta investigação, sentimos que uma abordagem explicitamente multidisciplinar era essencial, especialmente para casos associados a doenças sistêmicas.


Subject(s)
Humans , Cicatrix/etiology , Cicatrix/pathology , Ectropion/etiology , Ectropion/pathology , Lupus Erythematosus, Cutaneous/complications , Arthritis, Psoriatic/complications , Eyelids/pathology , Ichthyosis/complications
5.
Braz. dent. sci ; 22(4): 506-512, 2019. tab
Article in English | LILACS, BBO | ID: biblio-1024474

ABSTRACT

Introduction: Systemic lupus erythematosus is an autoimmune disease that affects multiple organs. It is well known that lupus patients have higher risk of osteoporosis, but if the disease affects mandibular cortical bone and alveolar bone is not fully established. Objective: The objective of this study was to evaluate periodontal disease defects and mandibular osteoporotic alterations in patients with lupus as compared to healthy patients using panoramic radiographs. Material and Methods: The panoramic radiographs of 72 patients with lupus and 360 healthy patients were evaluated for the presence of bone loss secondary to periodontal disease, classified as horizontal and vertical bone loss. We also assessed mandibular osteoporotic alterations by using the mandibular cortical index. Logistic regression analysis was applied to estimate the risk of mandibular osteoporotic alterations as well as horizontal and vertical bone loss in patients with lupus as compared to healthy patients. Results: There were no statistically significant differences between groups in the presence of horizontal bone defects and mandibular cortical indexes. However, patients with lupus demonstrated that patients with lupus were 2.17 more likely to present vertical bone loss than healthy patients. Conclusions: Patients with lupus might have higher risk of vertical bone loss than healthy patients due to pathophysiology of their disease. Further larger prospective studies should be performed to confirm our findings (AU)


Introdução: Os lúpus eritematoso sistêmico é uma doença autoimune que afeta múltiplos órgãos. Pacientes com lúpus têm maior risco de osteoporose, mas é necessário elucidar-se como a doença afeta o esqueleto maxilo-mandibular. Objetivo: O objetivo deste estudo foi avaliar defeitos ósseos por doença periodontal e alterações osteoporóticas mandibulares em pacientes com lúpus, em comparação com pacientes saudáveis, utilizando-se radiografias panorâmicas. Material e Métodos: As radiografias panorâmicas de 72 pacientes com lúpus e 360 pacientes saudáveis foram avaliadas quanto à presença de defeitos ósseos verticais e horizontais por doença periodontal. Foram também avaliadas as alterações osteoporóticas da mandíbula por meio do índice da cortical mandibular. A regressão logística foi aplicada para estimar o risco de alterações osteoporóticas mandibulares, bem como a perda óssea horizontal e vertical em pacientes com lúpus, em comparação com pacientes saudáveis. Resultados: Não houveram diferenças estatisticamente significantes entre os grupos no tocante à presença de defeitos ósseos horizontais quanto à redução da densidade mineral óssea aferida por meio do índice da cortical mandibular. No entanto, pacientes com lúpus apresentaram 2,17 mais risco à perda óssea vertical do que pacientes saudáveis. Conclusões: Pacientes com lúpus podem ter maior risco de apresentar defeito ósseo vertical do que pacientes saudáveis devido à fisiopatologia de sua doença. Novos estudos prospectivos devem ser realizados para confirmar estes achados (AU)


Subject(s)
Humans , Osteoporosis , Periodontal Diseases , Lupus Erythematosus, Cutaneous , Radiography, Panoramic , Bone Density , Lupus Erythematosus, Systemic
6.
Rev. chil. reumatol ; 35(4): 158-160, 2019. ilus
Article in Spanish | LILACS | ID: biblio-1282356

ABSTRACT

El mayor acceso a las terapias biológicas para el tratamiento de múltiples enfer-medades autoinmune trae consigo el mayor riesgo de padecer eventos adversos relacionados al uso de estos2,4. Presentamos un caso clínico de una paciente con diagnóstico de artritis reumatoide en tratamiento con ANTI TNF


The greater access to biological therapies for the treatment of multiple autoim-mune diseases brings with it the greatest risk of suffering adverse events related to the use of these (2,4). We present a clinical case of a patient diagnosed with rheumatoid arthritis in treatment with ANTI TNF


Subject(s)
Humans , Female , Middle Aged , Lupus Erythematosus, Cutaneous/etiology , Tumor Necrosis Factor Inhibitors/adverse effects , Arthritis, Rheumatoid/complications , Autoimmune Diseases/therapy
9.
Biociencias ; 13(1): [123-136], 2018. fig
Article in Spanish | LILACS, COLNAL | ID: biblio-969993

ABSTRACT

El lupus eritematoso sistémico (LES) esuna enfermedad de tipo autoinmune en donde existen múltiples factores que inducen una respuesta inmunológica no controlada en un individuo que genéticamente está predispuesto, presentándose una variedad de manifestaciones clínicas que muchas veces se convierten en un verdadero reto diagnóstico y terapéutico como es el caso de sus presentaciones en piel. Describiremos a continuación un caso de un paciente género masculino con diagnostico LES con lesiones cutáneas extensas severas con diagnóstico clínico yhistopatológico sugestivo de lupus ampolloso refractarias a tratamiento estándar con corticoterapia e inmunomoduladores con evolución tórpida en su curso, que requiere posteriormente inicio de terapia biológica con Belimumab observándose una remisión clínica significativa de las lesiones y contribuyendo además a disminuir las dosis de corticoides utilizadas desde su ingreso . Se revisaránaspectos en relación del LES en hombres en lo que refiere a epidemiologia, manifestaciones cutáneas, hallazgos histopatológicos, diagnóstico diferencial y opciones terapéuticas actuales.


Systemic lupus erythematosus (SLE) is an autoimmune disease in which multiple factors induce an uncontrolled immune response in an individual who is genetically predisposed, presenting a variety of clinical manifestations that often become a real diagnostic challenge and Therapeutic as in the case of their skin presentations. We will now describe a case of a malepatient with a SLE diagnosis with severe extensive skin lesions with clinical and histopathological diagnosis suggestive of blistering lupus refractory to standard treatment with corticosteroid therapy and immunomodulators with a morphologic evolution in their course, which then requires the initiation of biological therapy with Belimumab observed a significant clinical remission of the lesions and also contributing to decrease the doses of corticosteroids used since their entry. We will review aspects related to SLE in men in terms of epidemiology, cutaneous manifestations, histopathological findings, differential diagnosis and current therapeutic options


Subject(s)
Humans , Lupus Erythematosus, Cutaneous , Lupus Coagulation Inhibitor , Dermatology
10.
Med. interna (Caracas) ; 34(1): 36-42, 2018. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1008252

ABSTRACT

: relacionar el uso de hidroxicloroquina con la presencia de retinopatía en pacientes reumatológicos. Métodos: se realizó un estudio retrospectivo y descriptivo, de revisión de historias clínicas de pacientes reumatológicos en tratamiento con hidroxicloroquina. Se seleccionaron aquellos con evaluación oftalmológica previa al inicio del tratamiento y estudios como la OCT-SD. Se recolectaron variables clínico epidemiológicas, cálculo de dosis diaria y acumulada del fármaco, y duración del tratamiento. Resultados: se revisaron 150 historias, de las cuales 47 cumplieron con los criterios de inclusión; 44 (93,6%) eran del género femenino y 3 (6,4%) del género masculino. La edad promedio fue de 47 ± 14 años. La hipertensión arterial fue la comorbilidad más frecuente. La patología reumatológica más frecuente fue el Lupus (53,2%). La dosis diaria de hidroxicloroquina fue ≤ 6,5 mg/kg/día en los 47 pacientes; el tiempo promedio de consumo fue de 5 años; y la dosis acumulada promedio fue de 498,5 ± 503,68 gramos. Se detectó toxicidad retiniana en 18 pacientes (38,3%), de los cuales: 17(36,2%) tuvo daño precoz y 1 (2,1%) daño moderado. Se observó relación estadística significativa entre toxicidad retiniana y dosis acumulada menores a 1.000 gramos (p= 0,032) y un tiempo de consumo mayor o igual a 5 años (p = 0,045) Conclusiones: las alteraciones iniciales en las capas externas de la retina ayudan a la detección precoz de toxicidad retiniana por hidroxicloroquina, siendo la OCT-SD un método sensible y fácil de realizar en la práctica clínica(AU)


To establish the relationship between the use of hydroxychloroquine and retinopathies in rheumatologic patients. Methods: This is a retrospective, descriptive study of the medical charts of rheumatologic patients' who were receiving hydroxychloroquine. We selected patients previously seen in ophthalmologic services, and ophthalmologic coherence tomography (SD OCT) had been realized. We collected clinical and epidemiologic variables such as daily doses, accumulated doses and prescription duration. Results: we selected 47 medical charts; the female gender is 44 and three gender male. Mean age was 47 +14 years.Hypertension was the most frequent comorbidity.Lupus was the most frequent rheumatologic illness.Hydroxychloroquine daily dose was < 6.5 mg/Kg/day and treatment`s mean duration was 5 years; average accumulated dosage was 498.5 + 503.68 grs. We established retinal toxicity in 18 patients (38.3%), in which 17 (36.2%) had early damage, and 1(2.1%) had moderated damage. There was a statistical correlation between retinal toxicity and accumulated doses of less than 1.000 grs. (p: 0.032) as well as with time of use > 5 years (p:0.045) Conclusions: Early alterations of retinal superficial layers help in the detection of early retinal toxicity due to hydroxychloroquine use. OCTSD is a feasible and sensible study in daily medical practice(AU)


Subject(s)
Humans , Male , Female , Lupus Erythematosus, Cutaneous/drug therapy , Rheumatic Diseases/drug therapy , Hydroxychloroquine/administration & dosage , Hydroxychloroquine/adverse effects , Hypertension/physiopathology , Hypertensive Retinopathy , Internal Medicine
12.
Cambios rev. méd ; 16(1): 65-72, ene. - 2017. ilus
Article in Spanish | LILACS | ID: biblio-1000023

ABSTRACT

Introducción: El lupus eritematoso infantil incluye las distintas variedades de lupus eritematoso del adulto y además una forma exclusiva de la edad pediátrica: el lupus neonatal. Aunque el lupus eritematoso sistémico, subagudo y discoide pediátricos comparten las características esenciales de las formas correspondientes en los adultos, presentan algunas peculiaridades. Casos: Describimos cinco casos clínicos de lupus infantil, de distintos tipos, dos casos del subtipo discoide, dos subagudos y un ampollar. Discusión: Entre las diferencias más importantes cabe destacar que en el lupus sistémico infantil es más frecuente encontrar nefropatía, fiebre y linfadenopatías al inicio de la enfermedad que en adultos. Durante el desarrollo de la enfermedad es más común el exantema malar. El lupus subagudo es excepcional en la infancia.


Introduction: Systemic lupus erythematosus in children includes adult different varieties plus and exclusive pediatric presentation, neonatal lupus. Case: We describe five cases of SLE in children, two cases of discoid subtype, two subacute and one blistering. Discusion: Although pediatric systemic lupus erythematosus discoid and subacute share the essential features of the corresponding forms in adults, they also have some peculiarities. Among the most frequent are nephropathy, fever and lymphadenopathy at the onset of the disease, whereas, during the development of the disease malar rash is quite common.


Subject(s)
Child , Pathology , Pediatrics , Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Discoid , Lupus Erythematosus, Systemic , Skin , Joints , Kidney , Lung , Membranes , Nervous System
13.
Article in Korean | WPRIM | ID: wpr-165087

ABSTRACT

Acute cutaneous lupus erythematosus (ACLE) on the face is a usual pattern of presentation. However, it can rarely present with a generalized distribution. A hyperacute form of ACLE can mimic Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN). A 33-year-old man presented with erythematous eroded papules and patches on his head, neck, and upper chest over 2 months. Moreover, he showed hemorrhagic crusted erosions on his lips, and buccal and nasal mucosa, in addition to conjunctival injection. A skin biopsy from his cheek showed a mild degree of vacuolar alteration, thickening of the basement membrane, perivascular and periadnexal lymphohistiocytic infiltration, and stromal mucin deposition. Direct immunofluorescence (DIF) demonstrated IgG and IgM deposits along the basement membrane zone. Laboratory investigations demonstrated pancytopenia, positive antinuclear antibody (ANA), anti-double stranded DNA (anti-dsDNA), and anti-Ro antibodies. The patient was diagnosed with systemic lupus erythematosus (SLE) based on clinical, histological, and laboratory markers of autoimmune disease. We report a rare case of SLE presenting as SJS.


Subject(s)
Adult , Antibodies , Antibodies, Antinuclear , Autoimmune Diseases , Basement Membrane , Biomarkers , Biopsy , Cheek , Cytochrome P-450 CYP1A1 , DNA , Fluorescent Antibody Technique, Direct , Head , Humans , Immunoglobulin G , Immunoglobulin M , Lip , Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Systemic , Mucins , Nasal Mucosa , Neck , Necrosis , Pancytopenia , Skin , Stevens-Johnson Syndrome , Thorax
14.
Rev. méd. (La Paz) ; 23(2): 29-33, 2017. ilus
Article in Spanish | LILACS, LIBOCS | ID: biblio-902429

ABSTRACT

El Lupus Eritematosos Sistémico es el paradigma del síndrome autoinmune sistémico, cuya etiología está lejos de ser aclarada, aunque el conocimiento de su patogenia ha avanzado en estos últimos años inexorablemente, como el de los secretos más ocultos del funcionamiento del sistema autoinmune. Es mucho más frecuente en mujeres (10:1) y suele presentarse en la adolescencia tardía y a los 50 años, también es más frecuente y grave en algunos grupos étnicos, en especial afroamericanos e hispanos; su carácter crónico, su gran variedad clínica, sus episodios de activaciones y remisiones, la presencia de numerosos anticuerpos y la respuesta al tratamiento inmunosupresor son muestra de su naturaleza autoinmune. Presentamos el caso de un paciente de sexo masculino, de 38 años de edad, de origen hispano, que debutó con serositis, y que respondió de forma adecuada al tratamiento inmunosupresor instaurado.


Systemic Lupus Erythematosus is the paradigm of systemic autoimmune syndrome, whose etiologyis farfrom being clarified, although the knowledge of its pathogenesis has inexorably advanced in recent years, such as the most hidden secrets of the functioning of the autoimmune system. It is much more common in women (10: 1) and usually occurs in late adolescence and at age 50, is also more frequent and severe in some ethnic groups, especially African American and Hispanic; its chronic nature, its great clinical variety, its episodes of activation and remission, the presence of numerous antibodies and the response to immunosuppressive treatment are indicative of its autoimmune nature. We present the case of a 38-year-old male patient of Hispanic origin, who debuted with serositis, and who responded adequately to the immunosuppressive treatment instituted.


Subject(s)
Male , Adult , Lupus Erythematosus, Systemic/pathology , Signs and Symptoms , Lupus Erythematosus, Cutaneous/diagnostic imaging , Panniculitis, Lupus Erythematosus/immunology
15.
An. bras. dermatol ; 91(5,supl.1): 87-89, Sept.-Oct. 2016. graf
Article in English | LILACS | ID: biblio-837963

ABSTRACT

Abstract Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression. Histopathology reveals perivascular and periannexal lymphohistiocytic infiltrates in the papillary and reticular dermis and interstitial mucin deposition. Treatment is based on photoprotection, topical corticosteroids and antimalarials. We report two cases of lupus tumidus, which deserve attention for their low frequency in the literature, in addition to their relevance as a differential diagnosis among dermatologic disorders.


Subject(s)
Humans , Female , Middle Aged , Skin/pathology , Lupus Erythematosus, Cutaneous/pathology , Biopsy , Lupus Erythematosus, Cutaneous/drug therapy , Prednisone/therapeutic use , Chloroquine/therapeutic use , Treatment Outcome , Glucocorticoids/therapeutic use , Mucins , Antimalarials/therapeutic use
16.
Rev. colomb. reumatol ; 23(3): 195-199, jul.-set. 2016. ilus, tab
Article in Spanish | LILACS | ID: biblio-960210

ABSTRACT

El síndrome de Gardner-Diamond o púrpura psicógena es una vasculopatía de presunto origen autoinmune que se caracteriza por una reacción cutánea localizada, asociada a situaciones de estrés emocional. Se presenta el caso de una paciente con lesiones equimóticas, dolorosas y de aparición intermitente, relacionadas con diversos eventos estresores, que habían sido manejadas como manifestación de lupus


Gardner-Diamond syndrome or psychogenic purpura is an vasculopathy characterized by a localized cutaneous reaction, associated with episodes of emotional stress or mental illness as trigger factors. A case of a female patient with multiple, intermittent, nodular, ecchymotic and painful lesions related to various stressing events that was treated as lupus is reported below


Subject(s)
Humans , Lupus Erythematosus, Cutaneous , Diagnosis, Differential
17.
An. bras. dermatol ; 91(4): 510-513, July-Aug. 2016. graf
Article in English | LILACS | ID: lil-792435

ABSTRACT

Abstract: Chronic cutaneous lupus erythematosus in a linear configuration is rare, particularly in children, demonstrating similar incidence in both genders, no photo-sensitivity and lower probability of progression to systemic disease. We describe the case of a 9-year-old girl who presented erythematous papules with central atrophy on the upper and lower right limbs, asymptomatic and following the lines of Blaschko, since age four. Histological examination showed atrophy of the epidermis with aggression from epidermal-dermal interface and periadnexal and perivascular lymphocytic inflammatory infiltrate. Laboratory tests showed ANA in a titer of 1:320, in a dense and fine speckled pattern. Due to the rarity of presentation and location of the disease, this case is reported here.


Subject(s)
Humans , Female , Child , Lupus Erythematosus, Cutaneous/pathology , Epidermis/pathology , Atrophy , Biopsy
18.
Arch. pediatr. Urug ; 87(1): 22-27, mar. 2016. tab
Article in Spanish | LILACS | ID: lil-780102

ABSTRACT

Introducción: estudios recientes enfatizan la importancia de examinar el efecto del nivel socioeconómico sobre el desarrollo psicomotor infantil, en tal sentido las investigaciones informan que el nivel económico y el ambiente sociocultural en que se desenvuelve el niño son fundamentales para favorecer un normal desarrollo en la infancia Objetivos: proponer un modelo estadístico para predecir el puntaje de desarrollo psicomotor de niños y niñas de 4 a 5 años de edad en función del nivel socioeconómico. Metodología: se evaluó el desarrollo psicomotor a una muestra de 228 niños y niñas por medio de la aplicación de la batería TEPSI. Para determinar el nivel socioeconómico se aplicó una encuesta sociodemográfica a los padres y apoderados. Se efectuó un análisis correlacional bivariado no paramétrico, además se realizaron pruebas ANOVA de un factor, finalmente para modelar se efectuó un análisis de regresión múltiple. Resultados: los resultados reportaron que el nivel educacional del jefe de hogar y el ingreso per cápita correlacionan significativamente con el desarrollo psicomotor. Conclusiones: en cuanto a los modelos, se informa que fue posible diseñar tres modelos. El primero permite predecir un 4,2% del puntaje en el desarrollo psicomotor en función de la variable ingreso per cápita. El segundo modelo es capaz de predecir en un 11% el puntaje del lenguaje en base al variable ingreso per cápita. Por último, el tercer modelo, con bajo valor predictor (2,2%), permite predecir el puntaje de la coordinación en función del nivel educacional del jefe de hogar.


Introduction: recent studies emphasize the importance of examining the effect of socioeconomic status on child psychomotor development. In this sense, research conducted reports that the level of economic and cultural environment child operate in, are crucial for facilitating their normal development. Objectives: the study proposes a statistical model to predict the psychomotor development score of children from 4 to 5 years of age depending on the socio-economic level. Methodology: psychomotor development was evaluated in a sample made up of 228 boys and girls through the application of the psychomotor development test (TEPSI). A demographic survey was applied to parents and guardians to determine their socio-economic level. A non-parametric bivariate correlational analysis was performed, and a single factor ANOVA tests were carried out. Last, a multiple regression analysis was made for modelling purposes. Results: the results reported that the educational level of the head of household and the per capita income is significantly correlated with the psychomotor development. Conclusions: as to models, the possibility of designing three models is reported. The first one allows predicting 4.2 % of the psychomotor development score based on the per capita income variable. The second model is able to predict 11% of the language score based on the per capita income variable. Last, the third model, with low predictive value (2.2 %), enables predicting the coordination score, based on the educational level of the head of household.


Subject(s)
Humans , Male , Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Cutaneous/pathology , Infant, Newborn, Diseases/diagnosis
19.
Arch. pediatr. Urug ; 87(1): 28-32, mar. 2016. ilus
Article in Spanish | LILACS | ID: lil-780103

ABSTRACT

El lupus eritematoso neonatal (LEN) es una enfermedad muy poco frecuente que se presenta en el recién nacido, dada por el pasaje transplacentario de autoanticuerpos anti Ro/SSA, anti La/SSB y U1-RNP. Las principales manifestaciones clínicas son dermatológicas y cardíacas, pudiendo además presentar manifestaciones hepáticas, hematológicas y/o neurológicas. Presentamos un caso clínico de un lactante de 3 meses al que se le realizó diagnóstico de LEN en base a la presencia de lesiones cutáneas y hallazgos histopatológicos e inmunológicos compatibles, no se acompañó de manifestaciones sistémicas y presentó una muy buena evolución posterior. El interés del caso es mostrar una patología poco frecuente que suele presentarse con lesiones cutáneas características, destacando que el pronóstico estará determinado por el compromiso cardíaco y que permite en muchos casos realizar diagnóstico materno de una enfermedad autoinmune asintomática.


Neonatal lupus erythematosus (LEN) is a rare disease that occurs in the newborn given by the transplacental passage of maternal Anti-Ro/SSA, Anti-La/SSB and Anti-U1-RNP autoantibodies. The main clinical manifestations are dermatologic and cardiac, it may also have hepatic, hematologic or/and neurological ones. The study reports a case of a three month infant who is diagnosed with LEN, based on the presence of consistent findings of skin lesions and histopathology and immunology compatible findings. In this case, it was not accompanied by systemic manifestations evolution was a favorable one. The case is relevant since it presents an unusual condition that is usually accompanied by characteristic skin lesions, where prognosis is determined by cardiac involvement. In many cases, this enables maternal diagnosis of an asymptomatic autoimmune disease.


Subject(s)
Humans , Male , Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Cutaneous/pathology , Infant, Newborn, Diseases/diagnosis
20.
Article in Korean | WPRIM | ID: wpr-134781

ABSTRACT

Neonatal lupus erythematosus (NLE) is a rare autoimmune disease that has a clinical spectrum of cutaneous, cardiac, and systemic abnormalities in neonates. It is caused by transplacental passage of maternal anti-Ro and/or anti-La autoantibodies, which result in skin lesions such as subacute cutaneous lupus erythematosus, congenital heart block, and liver function and hematologic abnormalities. We report a case of NLE in a 31-day-old female infant who was born to a clinically asymptomatic mother with anti-SSA/Ro and anti-SSB/La antibodies. The baby presented with multiple erythematous patches and annular plaques on the face and trunk. The skin biopsy showed slight follicular plugging, focal hydropic degeneration of the basal epidermis and mild edema, telangiectasia, and perivascular and interstitial lymphohistiocytic infiltration in the upper dermis. Her serological tests were positive for antinuclear antibody (ANA), anti-SSA/Ro, and anti-SSB/La. These findings are consistent with NLE. The mother also had a positive autoantibody profile for ANA, anti-SSA/Ro, and anti-SSB/La without clinical symptoms.


Subject(s)
Antibodies , Antibodies, Antinuclear , Autoantibodies , Autoimmune Diseases , Biopsy , Dermis , Edema , Epidermis , Female , Heart Block , Humans , Infant , Infant, Newborn , Liver , Lupus Erythematosus, Cutaneous , Mothers , Serologic Tests , Skin , Telangiectasis
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