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An. bras. dermatol ; 95(3): 307-313, May-June 2020. tab, graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130882


Abstract Background: Clinical and histological features may overlap between lichen planopilaris-associated and discoid lupus erythematosus-associated scarring alopecia. Objectives: The aim of this study was to demonstrate the cutaneous infiltration of plasmacytoid dendritic cells and to compare their distribution pattern in discoid lupus erythematosus and lichen planopilaris. Methods: Twenty-four cases of discoid lupus erythematosus and 30 cases of lichen planopilaris were examined for immunostaining of the CD123 marker. The percentage and distribution pattern of plasmacytoid dendritic cells and the presence of the plasmacytoid dendritic cells clusters were evaluted in the samples. Results: The number of plasmacytoid dendritic cells was higher in the discoid lupus erythematosus specimens. Aggregations of 10 cells or more (large cluster) were observed in half of the discoid lupus erythematosus specimens and only 2 lichen planopilaris, with 50% sensitivity and 93% specificity for differentiating discoid lupus erythematosus from lichen planopilaris. Study limitations: Incidence and prevalence of discoid lupus erythematosus-associated scarring alopecia in the scalp are low, so the samples size of our study was small. Conclusions: We suggest that a plasmacytoid dendritic cells cluster of 10 cells or more is highly specific for distinguishing discoid lupus erythematosus from lichen planopilaris. It also appears that CD123 immunolabeling is valuable in both active and late stages of the disease.

Humans , Male , Female , Adult , Dendritic Cells/pathology , Lupus Erythematosus, Discoid/pathology , Interleukin-3 Receptor alpha Subunit/immunology , Lichen Planus/pathology , Reference Values , Staining and Labeling , Immunohistochemistry , Biomarkers , Retrospective Studies , Alopecia/pathology , Middle Aged
An. bras. dermatol ; 93(2): 274-276, Mar.-Apr. 2018. graf
Article in English | LILACS | ID: biblio-887172


Abstract: Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Frontal fibrosing alopecia is characterized by frontotemporal hairline recession and eybrow loss. Histophatologically, it cannot be differentiated from lichen planopilaris.It is controversial whether frontal fibrosing alopecia is a subtype of lichen planopilaris.. A pacient with chronic lichenoid lupus erythematosus is described with clinical, histophatological and dermoscopic features of frontal fibrosing alopecia.We have not been able to find in the literature cases of frontal fibrosing alopecia as a clinical manifestation of lupus.

Humans , Female , Middle Aged , Lupus Erythematosus, Discoid/complications , Lupus Erythematosus, Discoid/pathology , Alopecia/complications , Alopecia/pathology , Scalp/pathology , Biopsy , Fibrosis/pathology , Lichenoid Eruptions/pathology , Dermoscopy
An. bras. dermatol ; 91(5,supl.1): 14-16, Sept.-Oct. 2016. graf
Article in English | LILACS | ID: biblio-837955


Abstract Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases.

Humans , Female , Middle Aged , Sjogren's Syndrome/complications , Alopecia/complications , Fibrosis , Lupus Erythematosus, Discoid/complications , Lupus Erythematosus, Discoid/pathology , Hair Follicle/pathology , Dermis/pathology , Alopecia/immunology , Alopecia/pathology , Lichen Planus/immunology , Lichen Planus/pathology
An. bras. dermatol ; 91(5,supl.1): 122-124, Sept.-Oct. 2016. graf
Article in English | LILACS | ID: biblio-837945


Abstract A 40-year-old female patient with a 5-year history of systemic lupus erythematosus was referred to our policlinic with complaints of erythema, atrophy, and telangiectasia on the upper eyelids for 8 months. No associated mucocutaneous lesion was present. Biopsy taken by our ophthalmology department revealed discoid lupus erythematosus. Topical tacrolimus was augmented to the systemic therapeutic regimen of the patient, which consisted of continuous antimalarial treatment and intermittent corticosteroid drugs. We observed no remission in spite of the 6-month supervised therapy. Periorbital discoid lupus erythematosus is very unusual and should be considered in the differential diagnosis of erythematous lesions of the periorbital area..

Humans , Female , Adult , Lupus Erythematosus, Discoid/pathology , Eyelid Diseases/pathology , Lupus Erythematosus, Systemic/pathology , Biopsy , Tacrolimus/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Rare Diseases , Eyelids/pathology , Immunosuppressive Agents/therapeutic use
An. bras. dermatol ; 90(3,supl.1): 200-202, May-June 2015. ilus
Article in English | LILACS | ID: lil-755732



We present the rare case of a 47-year-old patient, suffering from cheilitis granulomatosa and lupus erythematosus discoid: this association is really exceptional because only once reported in English literature. In addition, the treatment of cheilitis granulomatosa is a challenge for the dermatologist: the gold standard, represented by steroids, is in fact designed as a short-time option. Our report confi rms the good efficacy of methotrexate as a steroid-sparing agent.


Humans , Male , Middle Aged , Dermatologic Agents/therapeutic use , Lupus Erythematosus, Discoid/drug therapy , Melkersson-Rosenthal Syndrome/drug therapy , Methotrexate/therapeutic use , Biopsy , Dermis/pathology , Lip/pathology , Lupus Erythematosus, Discoid/pathology , Melkersson-Rosenthal Syndrome/pathology , Treatment Outcome
JPAD-Journal of Pakistan Association of Dermatologists. 2014; 24 (1): 15-20
in English | IMEMR | ID: emr-157635


To document the frequency of cutaneous manifestation of systemic lupus erythematosus [SLE]. It was a case-series collected from Dermatology Department and all four Medical Units of Bahawal-Victoria Teaching Hospital of Quaid-e-Azam Medical, Bahawalpur. A total of 100 patients with diagnosis of SLE and fulfilling the inclusion criteria were included in the study. All the patients were evaluated for the cutaneous manifestations of SLE. All the information was collected in a specially designed proforma and analyzed with the help of SPSS version 10. The mean age of the patients was 25.97 +/- 4.64 years. 92% patients were female and 8% were male. Out of 100 patients, 85% patient presented with cutaneous manifestations. Photosensitivity was seen in 40 [40%] patients, discoid rash in 35 [35%], malar rash in 25 [25%], and oral ulcers in 24 [24%]. SLE is predominantly seen among female patients of young age. Photosensitivity is most common presentation, followed by discoid rash

Humans , Male , Female , Skin Diseases/epidemiology , Skin Diseases, Vascular/etiology , Photosensitivity Disorders/etiology , Lupus Erythematosus, Discoid/pathology , Hospitals, Teaching , Oral Ulcer/etiology
An. bras. dermatol ; 86(4,supl.1): 89-91, jul,-ago. 2011. ilus
Article in Portuguese | LILACS | ID: lil-604130


Lúpus eritematoso cutâneo crônico é doença autoimune, com apresentações polimorfas que podem, eventualmente, mimetizar outras condições clínicas, causando dificuldade diagnóstica. Quadro acneiforme, com comedões e lesões atróficas pontuadas (pitting scars) pode constituir apresentação atípica do lúpus eritematoso cutâneo discóide.

Chronic cutaneous lupus erythematosus is a polymorphous autoimmune disease which may mimic some other clinical conditions, causing diagnostic difficulties. Acneiform lesions, including comedones and pitting scars are occasionally atypical presentations of cutaneous discoid lupus erythematosus.

Adult , Female , Humans , Facial Dermatoses/pathology , Lupus Erythematosus, Discoid/pathology , Anti-Bacterial Agents/therapeutic use , Chronic Disease , Facial Dermatoses/drug therapy , Hydroxychloroquine/therapeutic use , Lupus Erythematosus, Discoid/drug therapy , Tetracycline/therapeutic use
An. bras. dermatol ; 86(3): 553-556, maio-jun. 2011. ilus
Article in Portuguese | LILACS | ID: lil-592151


O lúpus eritematoso crônico discoide linear é manifestação rara da doença lúpica cutânea, em que lesões eritêmato-atrófico-discrômicas dispõem-se nas linhas de Blaschko. Descrevemos o caso de um menino de 15 anos, com dois anos de história de lesões discoides eritêmato-atróficas, hipo e hiperpigmentadas, dispostas nas linhas de Blaschko do membro superior direito. O exame histopatológico revelou atrofia da epiderme, hiperqueratose, rolhas córneas, espessamento da zona da membrana basal, infiltrado inflamatório crônico perianexial e perivascular superficial e profundo, depósito de mucina na derme, confirmando o diagnóstico. Há, no total, 14 casos descritos dessa variante que se inicia frequentemente na infância e que não apresenta predomínio quanto ao sexo. As lesões ocorrem preferencialmente na face. Não há relatos de associação com doença sistêmica.

Linear chronic discoid lupus erythematosus is a rare manifestation of cutaneous lupus in which erythematous, atrophic, dyschromic lesions are located along the lines of Blaschko. This report describes the case of a 15-year old boy with a 2-year history of discoid, erythematous, hyper and hypopigmented lesions with central atrophy, situated along the lines of Blaschko on his right arm. Histopathology showed epidermal atrophy, hyperkeratosis, follicular plugging, thickening of the basement membrane zone, and superficial and deep chronic perivascular and periadnexal inflammatory infiltrate, with dermal mucin deposit, thus confirming diagnosis. A total of 14 cases have been described of this variant, the onset of which is often in childhood. There is no difference in incidence between genders. Lesions most commonly develop on the face. There have been no reports of any association with systemic disease.

Adolescent , Humans , Male , Lupus Erythematosus, Discoid/pathology , Chronic Disease
Clinics ; 63(6): 747-752, 2008. ilus, tab
Article in English | LILACS | ID: lil-497904


BACKGROUND: Scarring alopecias are classified into primary and secondary types according to the initial site of inflammation. In primary scarring alopecias, the hair follicle is the main target of destruction; the term secondary cicatricial alopecia implies that follicular destruction is not the primary pathologic event. AIMS: To review the histopathologic diagnoses of cases of cicatricial alopecia in order to classify them according to the North American Hair Research Society. PATIENTS AND METHODS: Patients with biopsy specimens diagnosed as cicatricial alopecia seen from 2000 to 2005 at the Dermatologic Department of Hospital das Clinicas, São Paulo University Medical School had hematoxylin and eosin, Periodic acid-Schiff and Weigert stained slides reevaluated and sub-typed into different primary cicatricial alopecias. RESULTS: Thirty-eight cases of primary cicatricial alopecias were reclassified as: chronic cutaneous lupus (17), lichen planus pilaris (4), pseudopelade of Brocq (12), folliculitis decalvans (3), dissecting folliculitis (1), and non-specific scarring alopecia (1). In our cases, the methods employed allowed an accurate diagnosis in 12 of 13 cases (92.3 percent) previously classified as non-specific cicatricial alopecias. CONCLUSIONS: Even in the late, pauci or non-inflammatory phases, an approach with systematic evaluation of a constellation of criteria in routine hematoxylin and eosin stain, Periodic acid-Schiff and Weigert stain allowed for a more accurate diagnosis of cicatricial alopecias.

Adult , Aged , Female , Humans , Male , Middle Aged , Alopecia/pathology , Cicatrix/pathology , Folliculitis/pathology , Lichen Planus/pathology , Lupus Erythematosus, Discoid/pathology , Alopecia/classification , Biopsy , Hospitals, University
Arch. argent. dermatol ; 49(1): 33-6, ene.-feb. 1999. ilus
Article in Spanish | LILACS | ID: lil-235172


Se describe un caso de lupus eritematoso discoide que comenzó en la infancia. El lupus eritematoso discoide es infrecuente en la edad infantil y se ha estimado que menos del 2 por ciento de los pacientes desarrollan la enfermedad antes de los 10 años. El trastorno es similar al lupus discoide del adulto, pero aparentemente presenta un riesgo elevado de progresar a lupus eritematoso sistémico

Humans , Male , Child , Lupus Erythematosus, Discoid/diagnosis , Autoimmune Diseases , Lupus Erythematosus, Cutaneous/classification , Lupus Erythematosus, Discoid/drug therapy , Lupus Erythematosus, Discoid/pathology
Gulf Journal of Dermatology and Venereology [The]. 1999; 6 (1): 58
in English | IMEMR | ID: emr-50776
Dermatología (Santiago de Chile) ; 10(4): 255-8, 1994. ilus
Article in Spanish | LILACS | ID: lil-144199


Diversas enfermedades cutáneas se caracterizan por alteraciones localizadas preferentemente en la zona de membrana basal. Estas dermatosis se han hereditarias y adquiridas. Se pueden encontrar cambios ultraestructurales en la membrana basal, muchos de los cuales serían causados por fenómenos autoinmunes. Múltiples investigaciones han permitido aclarar la morfogénesis de las lesiones clínicamente visibles que afectan esta zona en particular. En la presente revisión se realiza una puesta al día de la última información de la literatura sobre estas interesantes enfermedades

Humans , Basement Membrane/ultrastructure , Skin Diseases/pathology , Dermatitis Herpetiformis/pathology , Epidermolysis Bullosa Acquisita/pathology , Epidermolysis Bullosa, Junctional/pathology , Epidermolysis Bullosa Dystrophica/pathology , Epidermolysis Bullosa Simplex/pathology , Lupus Erythematosus, Discoid/pathology , Pemphigoid, Benign Mucous Membrane/pathology , Pemphigoid, Bullous/pathology