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1.
Oncología (Ecuador) ; 31(3): 251-259, 30-diciembre-2021.
Article in Spanish | LILACS | ID: biblio-1352471

ABSTRACT

Introducción: La neoplasia de células dendríticas plasmocitoides blásticas (NCDPB) es una patología agresiva y representa menos del 1% de neoplasias hematológicas, se caracteriza por lesiones cutáneas nodulares violáceas sin evidencia de adenopatías en la mayoría de casos. Estudios observacionales demuestran que el Protocolo de quimioterapia Hyper-CVAD y la consolidación con tras-plante de células progenitoras hematopoyéticas se han asociado con una mayor supervivencia general. Caso Clínico: mujer de 82 años con antecedentes de Diabetes Mellitus tipo con cinco meses de lesiones hiperpigmentadas, elevadas, induradas, violáceas no dolorosas en mejilla, brazos, tórax anterior y posterior y piernas. Evolución: En citometría de flujo se determinó un fenotipo compatible con células patológicas (5.86%) con CD123++, HLADR+++, NG2++, CD56+++, CD4++, que sugiere una NCDPB. La biopsia de médula ósea presentó infiltración. PET CT posterior a terapia corticoide: no evidencia enfermedad tumoral macroscópica metabólicamente activa. Se inicia tratamiento con Dexametasona, con lo que las lesiones cutáneas disminuyeron en un 80%. Se inició Quimioterapia Protocolo CHOP like, ha recibido 6 ciclos hasta octubre del 2021, actualmente en remisión completa. Conclusión: En el presente caso el curso clínico de la NCDPB no fue agresivo hasta el momento del cierre del caso presentando disminución del 80% de las lesiones.


Introduction: blast plasmacytoid dendritic cell neoplasia (BPDCN) is an aggressive pathology and represents less than 1% of hematological neoplasms, it is characterized by violaceous nodular skin lesions without evidence of adenopathy in most cases. Observational studies show that the Hyper-CVAD chemotherapy protocol and consolidation with transplantation of hematopoietic progenitor cells have been associated with greater overall survival. Clinical case: a 82-year-old woman with a history of type Diabetes Mellitus with five months of hyperpigmented, raised, indurated, non-painful violaceous lesions on the cheek, arms, anterior and posterior thorax and legs. Evolution: Flow cytometry determined a phenotype compatible with pathological cells (5.86%) with CD123 ++, HLADR +++, NG2 ++, CD56 +++, CD4 ++, which suggests a BPDCN. The bone marrow biopsy showed infiltration. PET CT after corticosteroid therapy: there is no evidence of metabolically active macroscopic tumor disease. Dexamethasone treatment was started, with which skin lesions decreased by 80%. The CHOP-like Chemotherapy Protocol was started, she has received 6 cycles until October 2021, currently in complete remission. Conclusion: In the present case, the clinical course of NCDPB was not aggressive until the moment of closure of the case, presenting a decrease of 80% of the lesions.


Subject(s)
Humans , Female , Aged, 80 and over , Case Reports , Lymphoma, T-Cell, Cutaneous , Dendritic Cell Sarcoma, Interdigitating , Dendritic Cells , Lymphoma
2.
Arq. bras. med. vet. zootec. (Online) ; 73(3): 747-751, May-June 2021. tab
Article in English | ID: biblio-1278348

ABSTRACT

Marcadores sorológicos são rotineiramente utilizados na prática clínica para o estadiamento de linfomas e para a determinação de seu prognóstico em humanos. No entanto, pouco se sabe sobre sua utilização em cães, mesmo os linfomas sendo neoplasias com alta prevalência nessa espécie. No presente estudo, as concentrações séricas do receptor solúvel de interleucina-2 (sIL-2R) e do antígeno do câncer 125 (CA 125) foram mensurados em 10 cães saudáveis e em 15 cães com linfoma cutâneo, utilizando-se o kit ELISA canino e a leitura em um Stat Fax modelo 2100 (sIL-2R), bem como o kit ELISA humano e a leitura pelo ELISYS UNO humano (CA 125). Os resultados mostraram que não houve diferença significativa (P<0,05) nas concentrações dos marcadores entre os grupos. Além disso, os resultados não apontaram significância clínica no estadiamento tumoral e estabelecimento do prognóstico em cães diagnosticados com linfoma cutâneo.(AU)


Subject(s)
Animals , Dogs , Biomarkers/blood , Receptors, Interleukin-2/blood , CA-125 Antigen/blood , Lymphoma/veterinary , Prognosis , Skin Neoplasms/veterinary
3.
Rev. colomb. cir ; 36(3): 514-519, 20210000.
Article in Spanish | LILACS | ID: biblio-1254383

ABSTRACT

Introducción. El linfoma puede afectar el tracto gastrointestinal de manera primaria o secundaria, y representa hasta el 2 % de todas las neoplasias malignas del intestino delgado y colon. El tracto gastrointestinal es la ubicación extraganglionar primaria más común en el linfoma no Hodgkin. Métodos. Se realizó una búsqueda de la literatura en las principales bases de datos académicas, con revisión de textos publicados sobre el tema en los últimos 5 años. Discusión. La presentación clínica del linfoma con compromiso gastrointestinal es inespecífica y, hasta en la mitad de los pacientes, se puede presentar de manera inicial con complicaciones que requieran manejo quirúrgico. Entre las principales se encuentran la perforación intestinal, el sangrado digestivo y la obstrucción intestinal


Introduction. Lymphoma can affect the gastrointestinal tract, primarily or secondarily, and accounts for up to 2% of all malignant neoplasms of the small intestine and colon. The gastrointestinal tract is the most common primary extranodal location in non-Hodgkin lymphoma. Methods. A literature search performed in the main academic databases, with a review of texts published on the subject in the last 5 years.Discussion. The clinical presentation of lymphoma with gastrointestinal involvement is nonspecific and, in up to half of the patients, it can present initially with complications that require surgical management. Among the main ones are intestinal perforation, digestive bleeding and intestinal obstruction.


Subject(s)
Humans , Gastrointestinal Neoplasms , Lymphoma , Gastrointestinal Tract , Intestinal Obstruction , Intestinal Perforation , Intussusception
4.
Chinese Journal of Oncology ; (12): 163-166, 2021.
Article in Chinese | WPRIM | ID: wpr-877500

ABSTRACT

The pathological classification and clinical manifestations of lymphoma are complex, and there are many difficult cases. Therefore, the cooperation of different disciplines is needed in the process of diagnosis and treatment. Multi-disciplinary treatment (MDT) strategy can reduce the misdiagnosis and mistreatment, shorten the waiting time, promote the standardization and individualization of treatment, and improve the treatment outcome. In order to promote the development of MDT strategy for lymphoma in China, China Anti-Cancer Association Lymphoma Committee, Chinese Association for Clinical Oncologists and Medical Oncology Branch of Chinese International Exchange and Promotion Association for Medical and Health care co-organized the national experts committee to formulate "Clinical Practice Guideline for Multi-disciplinary Treatment Strategy of Lymphoma in China" .


Subject(s)
China , Humans , Lymphoma/therapy , Medical Oncology , Treatment Outcome
5.
Rev. ANACEM (Impresa) ; 15(1): 18-25, 2021. graf, tab
Article in Spanish | LILACS | ID: biblio-1248003

ABSTRACT

INTRODUCTION: Before the start of the GES program in 2002, mortality was 128.2 deaths per million children under 15 years of age (RENCI). This public program managed to ensure the opportunity for diagnosis and treatment in children under 15 years of age and those less than 25 years of age who recur. Objective: To assess how GES has impacted on in-hospital mortality and lethality between1997and 2016. Methods: Retrospective case control study of 28,997 hospital discharges and 12,434 deaths analyzed using Prais-Weinstein time series between the years 1997 to 2016. They prepared contingency tables with data on: hospital discharges, age, sex and forecasts for 2001 and 2016. Fisher's p <0.05 test was used. Results: For the PreGes period an increase of 1.8% in the male crude mortality rate was observed, while for the Post Ges period an increase was observed with a breaking point at the end of 2008, with an increase of 11.04% compared to the PreGes period. An unexpected increase in the female mortality rate was observed. The odd's ratios associated with sex (higher mortality inmen than in women)0.816CI-0.679- 0.982; p <0.05; OR'S age 1,047 (0.981 per year) IC-1.044-1.051; p <0.0001 FORECAST (FONASA-1.942 IC 1.304-2.89 / ISAPRE = 2.186; IC = 1.267-3.773 p <0.005); Hospitalization days = 1.031 confirmed our research hypothesis 1.026-1.035 p <0.0001. Conclusion: This study found that there are statistically significant differences regarding hospital discharges between the public-private system, in relation to mortality andincreasein sustained crudemalemortality between the years1997 to 2016


INTRODUCCIÓN: Antes del inicio del programa GESen2002, la mortalidad era 128,2 muertes por millón de niños menores de 15 años (RENCI). Este programa público logró asegurar la oportunidad de diagnóstico y tratamiento en menores de15 años y aquellos menores de25añosque recidivan. Objetivo: Evaluar cómo el GES ha impactado en la mortalidad y letalidad intrahospitalaria entre1997a2016. Métodos: Estudio retrospectivo de control de casos en 28.997 egresos hospitalarios y 12.434 defunciones analizadas mediante series temporales de Prais-Weinstein entre los años 1997 a 2016. Se prepararon tablas de contingencia con datos sobre: egresos hospitalarios, edad, sexo y previsiones para2001y 2016.Se utilizóla prueba p <0.05de Fisher. Resultados: Se observó para el período PreGES un incremento de 1.8% en la tasa mortalidad cruda masculina, mientras que para el período Post GES se observó un incremento con punto de quiebre a fines del año 2008, con incremento del 11,04% respecto al período PreGES. Se observó incremento no sostenido en la tasa mortalidad femenina. Los odd's ratios asociados al sexo (mayor mortalidad en hombres que en mujeres) 0.816 IC-0.679-0.982; p <0,05; OR'S edad 1,047 (0.981 por año) IC-1.044-1.051; p<0.0001 PREVISIÓN (FONASA-1.942 IC 1.304-2.89 / ISAPRE =2.186; IC= 1,267-3,773 p<0.005); Días de Hospitalización=1,031 confirmó nuestra hipótesis de investigación 1,026-1,035 p<0.0001. Conclusión: Este estudio encontró que hay diferencias estadísticamente significativas respecto egresos hospitalarios entre el sistema público privado, en relación con la mortalidad e incremento en la mortalidad cruda masculina sostenida entre los años 1997 a 2016. acción en la función auditiva mediante audiometría tonal.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Leukemia , Hospital Mortality , Hematologic Neoplasms/mortality , Hospitals/statistics & numerical data , Chile/epidemiology , Retrospective Studies , Risk Factors , Models, Statistical , Lymphoma
6.
Med. lab ; 25(3): 593-603, 2021. tabs
Article in Spanish | LILACS | ID: biblio-1343483

ABSTRACT

Las urgencias oncológicas son un reto para el clínico. El síndrome de vena cava superior es una emergencia hemato-oncológica en pediatría, el cual se define como la obstrucción intrínseca o extrínseca de la vena cava superior. La clínica más frecuente en pediatría es la aparición de circulación colateral, edema en esclavina y cianosis facial. El diagnóstico es clínico y debe hacerse lo menos invasivamente posible y de una manera rápida, para iniciar cuanto antes su manejo. Los linfomas, el uso prolongado de catéter venoso central y la cirugía cardiovascular en cardiopatías congénitas, son las principales etiologías. En algunas ocasiones, puede ser necesario un tratamiento empírico para salvar la vida del paciente, mediante el uso de esteroides y radioterapia. El objetivo del presente artículo es revisar y actualizar los aspectos más importantes sobre la etiología, las manifestaciones clínicas, el diagnóstico y el tratamiento del síndrome de vena cava superior en pediatría


Oncological emergencies are a challenge for the clinician. The superior vena cava syndrome is a hemato-oncological emergency in pediatrics; it is defined as an intrinsic or extrinsic obstruction of the superior vena cava. The most frequent clinical manifestations in children are the appearance of collateral circulation, edema in the body and facial cyanosis. The diagnosis is clinical and should been done as little invasively as possible and without delay to start its management as soon as possible. Lymphomas, prolonged use of a central venous catheter, and cardiovascular surgery in congenital heart disease are the main etiologies. In some cases, empirical treatment may be necessary to save the patient's life, through the use of steroids and radiotherapy. The aim of this article is to review and update the most important aspects of the etiology, clinical manifestations, diagnosis and treatment of the superior vena cava syndrome in pediatrics


Subject(s)
Superior Vena Cava Syndrome , Pediatrics , Critical Care , Lymphoma , Medical Oncology , Neoplasms
7.
Rev. ANACEM (Impresa) ; 15(1): 49-54, 2021. ilus
Article in Spanish | LILACS | ID: biblio-1281435

ABSTRACT

INTRODUCCIÓN: Los tumores de mediastino constituyen una entidad clínica poco frecuente, generalmente asintomática. Se pueden desarrollar desde estructuras que se ubican en el compartimento anterior, medio y posterior, siendo la primera, la ubicación más usual. En los adultos, timomas y linfomas (Hodgkin y no Hodgkin) son las masas más comunes del mediastino anterior, junto al bocio endotorácico y los teratomas; todas en su conjunto son conocidas como las "4 T del Mediastino Anterior". Casos clínicos: Se exponen tres casos clínicos de tumores de mediastino anterior, intervenidos en nuestro centro. Discusión: Las masas mediastínicas constituyen una entidad clínica infrecuente. La tomografía computada de tórax con y sin contraste intravenoso es utilizada para evaluar estas anormalidades descubiertas radiográficamente. El diagnóstico definitivo generalmente requiere una muestra de tejido que se obtiene mediante biopsia antes del tratamiento o como parte de una resección terapéutica planificada de toda la masa. En Chile, existen pocos trabajos recientes que muestren las características clínicas de pacientes que presentan timomas o linfomas; es por esto que se hace importante la presentación de estos casos que constituyen un aporte al conocimiento nacional.


INTRODUCTION: Mediastinal tumours constitute a clinical entity infrequent, generally asymptomatic. It can develop from structures localized on anterior compartment, middle and posterior, where structure localized on anterior compartment is usual. Adults tend to have thymomas and lymphomas more common in anterior mediastinal within intrathoracic goiter and teratomas. They are known as a "4T of anterior mediastinal mass". Clinical cases: Three clinical cases of anterior mediastinal tumours are exposed in our centre. Discussion: Mediastinal mass constitutes a clinical entity infrequent. The computed Tomography of the thorax with intravenous contrast and without intravenous contrast are used to evaluate abnormalities discover by radiography. The final diagnosis requires a fabric sample which is obtained by a biopsy before the treatment or as a part of a planned therapeutic recession. In Chile exist a few recently studies that shows clinical characteristics of patients which presents thymus and lymphomas as a result is important to present this kind of cases due to these cases constitute to the national knowledge.


Subject(s)
Humans , Male , Adult , Middle Aged , Thymoma/diagnostic imaging , Lymphoma/diagnostic imaging , Mediastinal Neoplasms/diagnostic imaging , Hodgkin Disease , Thoracotomy , Tomography, X-Ray Computed , Hospitals, Public , Lymphoma/therapy , Mediastinal Neoplasms/surgery
8.
Article in English | WPRIM | ID: wpr-880694

ABSTRACT

Lymphoma is one of the most common malignant tumor of the hematologic system. The genome instability is not only an important molecular basis for the development of lymphoma, but also has important value in the diagnosis and prognosis of lymphoma. There are 2 types of genome instability: Microsatellite instability (MSI/MIN) at gene level and chromosomal instability at chromosome level. Through the study on genes associated with lymphoma, the unstable genes associated with lymphoma could be found, meanwhile the mechanism of its occurrence and development of lymphoma could be explored, and the important basis of molecular biology could also be provided in the field of current hot lymphoma precision medical research.


Subject(s)
Genomic Instability , Humans , Lymphoma/genetics , Microsatellite Instability , Microsatellite Repeats , Neoplasms
9.
Journal of Experimental Hematology ; (6): 1007-1010, 2021.
Article in Chinese | WPRIM | ID: wpr-880184

ABSTRACT

Cancer cell lines are an indispensable tool in the cancer research. Since the first human cell line, HeLa was established in the 1950s, thousands of cancer cell lines have been established, including 637 characterized leukemia-lymphoma cell lines. The probability to successfully establish cancer cell lines is a low by traditional methods, and the addition of regulatory factors is often required. However, a novel "conditional reprogramming" technology can improve this situction. The establishment and description of a new cell line should be consistent with international guidelines. Cancer cell lines are mainly used in the research of tumor pathogenesis and drug development. Scientists have developed many kinds of cell line panels which can be used for the high-throughput screening of anticancer drugs. Mycoplasma contamination and/or cross-contamination from other cells should be avoided during the use of cell lines. The establishment of a cell model passport database can prevent those misidentifications. In this review, the types, establishment and usage of leukemia-lymphoma cell lines as well as points of attention when using them are summarized briefly.


Subject(s)
Cell Line , Humans , Leukemia , Lymphocytes , Lymphoma
10.
Article in Chinese | WPRIM | ID: wpr-880145

ABSTRACT

OBJECTIVE@#To analyze the influence of bone marrow involvement (BMI) in patients with malignant lymphoma (ML) on laboratory indexes, and evaluate the laboratory markers that can be used to predict/diagnose BMI.@*METHODS@#The clinical characteristics and laboratory indexes of 137 ML patients were analyzed retrospectively, from which the indexes of BMI in ML patients was studied. The logistic regression analysis and receiver operating curve (ROC) were used to evaluate independent risk factors and predictors of BMI diagnosis in ML patients.@*RESULTS@#Compared with non-BMI group, the red blood cell distribution width, C-reactive protein, erythrocyte sedimentation rate, D-dimer, lactate dehydrogenase, alkaline phosphatase, β@*CONCLUSION@#PLT and sIL2R show good diagnostic value for ML patients with BMI.


Subject(s)
Bone Marrow , Humans , Laboratories , Lymphoma , Prognosis , Retrospective Studies
11.
Article in Chinese | WPRIM | ID: wpr-880101

ABSTRACT

OBJECTIVE@#To investigate the effect of 2-methoxyestradiol (2-ME2) to lymphoma Raji cells and its mechanism.@*METHODS@#Different concentrations of 2-ME2 were used to treat lymphoma Raji cells. CCK8 method was used to detect the effect of 2-ME2 to proliferation of Raji cells. Flow cytometry FITC/PI double labeling method was used to detect early apoptosis of the cells. Western blotting was used to detect the effect of 2-ME2 to the expression of BCL-2, Bax, Caspase-3 and C-myc proteins in Raji cells.@*RESULTS@#2-ME2 significantly inhibited the proliferation of Raji cells. The inhibition rate increased with the increasing of drug concentration, and increased significantly with the prolongation of drug treatment time (r=0.9215). Flow cytometry FITC/PI double staining showed that the apoptotic rate of 2.5 μmol/L 2-ME2 treatment group was (33.79±1.63) %, while the apoptosis rate of the 48 h group was (51.90±2.72) %, and that of the control group was (7.08±0.36) %. After treated with 2.5 μmol/L 2-ME2 for 12 h, the expression of Bax protein was up-regulated, BCL-2 protein was down-regulated, caspase-3 protein expression was up-regulated, and C-myc protein expression was down-regulated, all of them showed a time-dependent relationship.@*CONCLUSION@#2-ME2 shows obvious inhibitory effect on lymphoma Raji cells in a dose- and time-dependent manner. Its mechanism of treatment on lymphoma Raji cells may be related to up-regulation of Bax/BCL-2 ratio and activation of Caspase-3 to induce apoptosis in cancer cells. Down-regulation of C-myc protein expression also participates in the apoptotic process.


Subject(s)
2-Methoxyestradiol , Apoptosis , Caspase 3/metabolism , Cell Line, Tumor , Cell Proliferation , Humans , Lymphoma , Proto-Oncogene Proteins c-bcl-2/metabolism , Up-Regulation , bcl-2-Associated X Protein
12.
Rev. colomb. reumatol ; 27(4): 298-302, oct.-dic. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1289334

ABSTRACT

RESUMEN La combinación de sarcoidosis y linfoma (síndrome sarcoidosis-linfoma) es una asociación poco frecuente pero reconocida en el ámbito clínico. Algunas manifestaciones pueden ser comunes entre estas entidades, por lo que es un reto para el clínico diferenciar cada enfermedad por separado o si coexisten en un mismo individuo. En este último escenario, ni las manifestaciones clínicas ni los parámetros de laboratorio son específicos, por lo que es necesario un análisis minucioso de cada caso, apoyado de laboratorios, imágenes e histopatología para llegar a un diagnóstico certero. Se presentan 2 casos de síndrome sarcoidosis-linfoma y se analizan los aspectos clave en el diagnóstico de esta forma clínica.


ABSTRACT The combination of sarcoidosis and lymphoma (sarcoidosis-lymphoma syndrome) is a rare but recognised clinical condition. Some manifestations may be common among these conditions, making it a challenge for the clinician to differentiate each disease separately, or if they coexist in the same individual. In this latter scenario, neither the clinical manifestations nor the laboratory parameters are specific, so a meticulous analysis of each case is necessary, supported by laboratory and imaging tests, and histopathology in order to obtain an accurate diagnosis. Two cases of sarcoidosis-lymphoma syndrome are presented, and an analysis is presented on the key aspects in the diagnosis of this clinical condition.


Subject(s)
Humans , Male , Female , Adult , Sarcoidosis , Lymphoma , Signs and Symptoms , Syndrome , Disease , Diagnosis , Reference Parameters
14.
Rev. cuba. hematol. inmunol. hemoter ; 36(4): e1244, oct.-dic. 2020. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289418

ABSTRACT

Introducción: La citometría de flujo es una técnica de avanzada, objetiva y altamente sensible que permite el análisis y la cuantificación simultánea de múltiples parámetros celulares, muy utilizada en el estudio de la leucemia linfoide crónica, entidad caracterizada como un trastorno proliferativo maligno de linfocitos de aspecto maduro e incompetentes. Objetivo: Describir la estrategia de diagnóstico del inmunofenotipaje por citometría de flujo de la leucemia linfoide crónica. Métodos: Se analizó una muestra de médula ósea para la citometría de flujo de un paciente con sospecha clínica y morfológica de la leucemia linfoide crónica. El inmunofenotipaje celular se realizó con el empleo de anticuerpos monoclonales dirigidos contra los antígenos de diferenciación linfoides B y T. Se procedió a la lectura de la muestra en un citómetro GALLIOS, Beckman Coulter y los datos obtenidos se analizaron con el empleo del programa informático Kaluza. Resultados: Los antígenos con expresión positiva fueron el CD19 (99,94 por ciento), CD20 (81,56 por ciento), CD5 (80,25 por ciento), así como la coexpresión de CD5+/CD19+ (96,56 por ciento), CD5+/CD20+ (80,56 por ciento), CD19+/CD20+ (84,86 por ciento), CD23 (62,65 por ciento), CD49d (65,18 por ciento), CD38 (52,17 por ciento). Se encontró monoclonalidad de la cadena ligera k en un 44,27 por ciento. La expresión de los antígenos CD3, CD4, CD8y CD25 resultó negativa. Conclusiones: La estrategia diagnóstica propuesta permitió identificar los antígenos más frecuentemente expresados en pacientes con leucemia linfoide crónica, así como la coexpresión de los mismos y la monoclonalidad de la cadena k, los cuales son marcadores celulares que permiten realizar el diagnóstico inmunofenotípico de la leucemia linfoide crónica, por citometría de flujo(AU)


Introduction: Flow cytometry is an advanced, objective, highly sensitive technique for the simultaneous analysis and quantification of multiple cellular parameters. This technique is very common in the study of chronic lymphocytic leukemia, a condition defined as a malignant proliferative disorder of mature, incompetent lymphocytes. Objective: Describe the diagnostic strategy for flow cytometry immunophenotyping of chronic lymphocytic leukemia. Methods: Flow cytometry testing was performed of a bone marrow sample taken from a patient with clinical and morphological suspicion of chronic lymphocytic leukemia. Cell immunophenotyping was based on monoclonal antibodies targeted against lymphoid differentiation antigens B and T. The sample was read in a GALLIOS Beckman Coulter cytometer, and the data obtained were analyzed with the software Kaluza. Results: Antigens with a positive expression were CD19 (99.94 percent), CD20 (81.56 percent), CD5 (80.25 percent), as well as the co-expression of CD5+/CD19+ (96.56 percent), CD5+/CD20+ (80.56 percent), CD19+/CD20+ (84.86 percent), CD23 (62.65 percent), CD49d (65.18 percent), CD38 (52.17 percent). Monoclonality of the k light chain was present in 44.27 percent. Expression of antigens CD3, CD4, CD8 and CD25 was found to be negative. Conclusions: The diagnostic strategy proposed made it possible to identify the antigens most frequently expressed in patients with chronic lymphocytic leukemia, as well as their co-expression and the monoclonality of the k chain, all of which are cell markers allowing flow cytometry-based immunophenotypical diagnosis of chronic lymphocytic leukemia(AU)


Subject(s)
Humans , Flow Cytometry/methods , Lymphoma/diagnosis
15.
Rev. bras. ciênc. saúde ; 24(3): 465-474, set. 25, 2020. tab
Article in Portuguese | LILACS, ColecionaSUS, CONASS, SES-MA | ID: biblio-1179431

ABSTRACT

Objetivo: Avaliar o perfil nutricional de pacientes onco-hematológicos internados em um hospital especializado em câncer em São Luís - MA. Metodologia: Estudo transversal, retrospectivo, analítico, com coleta de dados secundária, envolvendo pacientes com idade mínima de 18 anos, de ambos os gêneros e que tenham sido submetidos a pelo menos uma ASG-PPP (Avaliação Subjetiva Global Produzida Pelo Paciente). Os dados foram coletados em registros do Serviço de Nutrição e Dietética do hospital. Analisaram-se dados demográficos (gênero e idade), clínicos (diagnóstico) e nutricionais: Índice de massa corporal (IMC), circunferên-cia braquial (CB), prega cutânea tricipital (PCT), circunferência muscular do braço (CMB) e ASG-PPP. As análises foram realizadas no programa estatístico Stata® 13.0. O nível de significância utilizado para os testes foi de p<0,05. Resultados: Foram avaliados 330 pacientes, onde foi constatado que 67,58% eram de adultos e 32,42% de idosos, com maior frequência do sexo masculino, com 60,30%. Ocorreu maior incidência de leucemia (58,48%), seguidos de linfomas (24,85%), mieloma múltiplo (13,33%) e síndrome mielodisplásica (3,3%). Na avaliação do estado nutricional os resultados mostraram que a ASG-PPP detectou maior número de pacientes com algum grau de desnutrição do que outros indicadores (93,94%), seguido pela PCT (65,76%), CMB (53,64%), CB (45,45%) e IMC (14,87%). De acordo com o IMC, foi encontrado maior incidência de eutrofia, correspondendo a 57,27% da amostra. Conclu-são: Diante do que foi encontrado, destaca-se que a desnutrição é um aspecto de extrema importância a ser considerado no tratamento de pacientes onco-hematológicos, visto que pode interferir diretamente no prognóstico da doença. (AU)


Objective: To evaluate the nutritional profile of onco-hematological patients admitted to a specialized cancer hospital in São Luís - MA. Methodology: Cross-sectional, retrospective, analytical study, with secondary data collection, involving patients aged at least 18 years, of both genders and having undergone at least one ASG-PPP (Subjective Global Assessment Produced by the Patient). Data were collected from records of the Hospital's Nutrition and Dietetics Service. Demographic (gender and age), clinical (diagnostic) and nutritional: Body Mass Index (BMI), Brachial Circumference (CB), Tricipital Skinfold (PCT), Muscular Arm Circumference (CMB) and ASG-PPP data were analyzed. The analyses were performed using the Stata® 13.0 statistical program. The level of significance used for the tests was p<0.05. Results: 330 patients were evaluated, in which it was found that 67.58% are adults and 32.42% are elderly, with a higher frequency of males with 60.30%. There was a higher incidence of Leukemia (58.48%), followed by Lymphomas (24.85%), Multiple Myeloma (13.33%) and Myelodysplastic Syndrome (3.3%). In the assessment of nutritional status, the results showed that ASG-PPP detected a greater number of patients with some degree of malnutrition than other indicators (93.94%), followed by PCT (65.76%), CMB (53.64%), CB (45.45%) and BMI (14.87%). According to the BMI, a higher incidence of eutrophy was found, which corresponds to 57.27% of the sample. Conclusion: In view of what was found, it is highlighted that malnutrition is an extremely important aspect to be considered in the treatment of onco-hematological patients, since it can directly interfere in the prognosis of the disease. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Myelodysplastic Syndromes , Leukemia , Body Mass Index , Nutritional Status , Morbidity , Malnutrition , Diagnosis , Nutritional Sciences , Lymphoma , Neoplasms , Patients , Therapeutics , Cancer Care Facilities , Records , Demographic Data , Public-Private Sector Partnerships
16.
Rev. colomb. reumatol ; 27(3): 224-229, jul.-set. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1251663

ABSTRACT

RESUMEN Los síndromes paraneoplásicos neurológicos se presentan en menos del 1% de los tumores sólidos y son infrecuentes en linfomas. Se asocian a tumores con alta actividad biológica y condicionan deterioro funcional y discapacidad. La dermatomiositis se asocia a cáncer, por tanto obliga al estudio de neoplasias ocultas; su diagnóstico como síndrome paraneoplásico se establece con criterios específicos. El pronóstico funcional depende del diagnóstico oportuno, control del cáncer y de la regulación de la respuesta inmunológica. Se presenta el caso de una mujer de 65 años con dermatomiositis en el curso de un linfoma B marginal variante convencional de primario cutáneo.


ABSTRACT Neurological paraneoplastic syndromes occur in less than 1% of solid tumours and are uncommon in lymphomas. They are related to tumours with high biological activity and cause functional impairment and disability. Dermatomyositis is associated with cancer, and requires the study of hidden neoplasms. Its diagnosis as a paraneoplastic syndrome is established with specific criteria. Functional prognosis depends on early diagnosis, cancer control, and regulation of the immune response. The case is presented of a 65 year-old woman with dermatomyositis during the course of a conventional variant of a primary cutaneous B marginal lymphoma.


Subject(s)
Humans , Female , Middle Aged , Dermatomyositis , Lymphoma , Paraneoplastic Syndromes , Diagnosis , Neoplasms
17.
Rev. méd. panacea ; 9(2): 90-97, mayo-ago. 2020. ilus, tab, graf
Article in Spanish | LILACS, LIPECS | ID: biblio-1121163

ABSTRACT

Los linfomas son el conjunto de enfermedades neoplásicas de los linfocitos. El diagnóstico se fundamenta en la anamnesis, examen físico, biopsia ganglionar y estudios imagenológicos que permiten valorar la enfermedad para su estadiación y tratamiento. Objetivo: Caracterizar a partir de indicadores clínico-histo-imagenológico en casos con linfomas de localización mediastinal atendidos en el Instituto Nacional de Oncología y Radiobiología de Septiembre de 2017 a Diciembre de 2019. Materiales y métodos: Se realizó un estudio preliminar, descriptivo, prospectivo en una población de 167 casos y una muestra de 43 pacientes con linfomas de localización mediastinal. Se estudiaron las variables: sexo, edad, índice de masa corporal, síntomas y signos, tipo de tumor, subtipo histológico, estadiación por criterios de Ann-Arbor, tamaño ganglionar y localización mediastinal. Resultados: El pico de incidencia se observó entre los 25-35 años. La mayor cantidad de casos presentaron sobrepeso (n=10; 23,3%). Predominaron los Linfomas de Hodgkin (n=31; 71,8%) subtipo Esclerosis Nodular (n=22; 51,2%) con estadio IA (LH=14; 32,6%). El tamaño promedio de los ganglios fue de 25,1±17,3 mm. En todos los niveles de la anatomía mediastínica se observaron lesiones ganglionares, a predominio del mediastino superior. Otras características predominantes observadas por TC incluyeron ganglios hipodensos homogéneos (n=34; 79,07%), realce postcontraste con captación homogénea (n=24; 55,81), invasión de estructuras vecinas (n=18; 41,8%) y densidades entre 32-108 UH. Conclusiones: En la valoración de los indicadores imagenológicos por tomografía computarizada contrastada se detectan cambios morfológicos, al tomar como criterio fundamental la afectación ganglionar y el tamaño de las adenopatías en el diagnóstico, estadiamiento y reevaluación de casos con linfomas. (AU)


Lymphomas are the group of neoplastic diseases of lymphocytes. The diagnosis is based on the anamnesis, physical examination, lymph node biopsy and imaging studies that allow the disease to be assessed for its statistics and treatment. Objective: To characterize, with clinical-histological-imaging indicators, cases with lymphomas of mediastinal location treated at the National Institute of Oncology and Radiobiology from September 2017 to December 2019. Materials and methods: A preliminary, descriptive, prospective study was conducted in a population of 167 cases and a sample of 43 patients with lymphomas of mediastinal location. Variables were studied: sex, age, body mass index, symptoms and signs, tumor type, histological subtype, statistics by Ann-Arbor criteria, lymph node size and mediastinal location. Results: The peak incidence was recorded between 25-35 years. The highest number of specific cases of overweight (n = 10; 23.3%). Hodgkin lymphomas (n = 31, 71.8%), Nodular sclerosis subtype (n = 22, 51.2%) with stage IA (LH = 14, 32.6%) predominated. The average size of the nodes was 25.1 ± 17.3 mm. Nodal lesions were observed at all levels of the mediastinal anatomy, a predominance of the upper mediastinum. Other predominant features observed by CT include homogeneous hypodense nodes (n = 34; 79.07%), post-contrast enhancement with homogeneous uptake (n = 24; 55.81), invasion of neighboring structures (n = 18; 41.8%) and densities between 32-108 UH. Conclusions: Morphological changes were detected in the evaluation of the imaging indicators by contrast computed tomography, taking lymph node involvement and the size of lymphadenopathy as a fundamental criterion in the diagnosis, staging and reevaluation of cases with lymphomas. (AU)


Subject(s)
Humans , Male , Female , Adult , Tomography, X-Ray Computed , Lymph Node Excision , Lymphoma/diagnostic imaging , Mediastinal Neoplasms/diagnostic imaging , Epidemiology, Descriptive , Prospective Studies
18.
Arq. bras. med. vet. zootec. (Online) ; 72(3): 754-760, May-June, 2020. ilus, tab
Article in English | ID: biblio-1129169

ABSTRACT

A captive 7-year-old male bush dog (Speothos venaticus) was diagnosed with lymphoma affecting the kidneys, adrenal glands, liver, and spleen. The animal developed renal failure and was euthanized due to poor prognosis. Grossly, both kidneys were enlarged with multiple nodules. Histologically, the neoplasm was an infiltrative and poorly demarcated round cell tumor. Two morphologically distinct cell populations were observed, smaller cells with a lymphocytic morphology, and another population of larger and pleomorphic cells. Most of the smaller cell population, approximately 40% of the population within the neoplasm, were CD3 positive. Neoplastic cells were CD45, CD11d, and granzime B positive, and negative for CD20, CD79a, PAX5, CD163, and myeloperoxidase. This is the first reported case of lymphoma in a bush dog. This report demonstrated the suitability of several cell surface markers for differential diagnosis of round cell tumors in this species.(AU)


Um cachorro-do-mato-vinagre (Speothos venaticus), de sete anos de idade, mantido em cativeiro, foi diagnosticado com linfoma que havia afetado os rins, as adrenais, o fígado e o baço. O animal desenvolveu insuficiência renal e foi submetido à eutanásia devido ao prognóstico desfavorável. Macroscopicamente, ambos os rins estavam aumentados de tamanho, com múltiplos nódulos. Histologicamente, a neoplasia era infiltrativa, pobremente delimitada e constituída por células redondas. Duas populações distintas foram observadas: células pequenas com morfologia linfocítica e células grandes e pleomórficas. A maior parte da população de células pequenas, correspondendo a aproximadamente 40% da população celular na neoplasia, foi positiva para CD3. As células neoplásicas foram positivas para CD45, CD11d e granzima B e negativas para CD20, CD79a, PAX5, CD163 e mieloperoxidase. Este é o primeiro caso de linfoma em um cachorro-do-mato-vinagre. Tal relado demonstra a utilidade de vários marcadores de superfície celular para o diagnóstico diferencial de tumores de células redondas nessa espécie.(AU)


Subject(s)
Animals , Male , Dogs , Extranodal Extension , Lymphoma/veterinary , Immunohistochemistry/veterinary , Renal Insufficiency/veterinary , Animals, Wild
19.
Rev. argent. reumatolg. (En línea) ; 31(2): 37-40, jun. 2020. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1143930

ABSTRACT

Presentamos los casos clínicos de tres pacientes adultos jóvenes de origen boliviano, que fueron hospitalizados en salas de clínica médica de un hospital de tercer nivel por manifestaciones de la vía aérea superior y lesiones de las estructuras de la línea media. Reumatología evaluó la posibilidad del diagnóstico de Vasculitis asociada a ANCA, la cual es un diagnóstico diferencial de la entidad conocida como "lesión destructiva de la línea media". En todos los casos se arribó al diagnóstico definitivo de Linfoma T luego de un exhaustivo estudio histopatológico.


We present clinical cases of three Bolivian young adults who were hospitalized in the medical clinic rooms of a third level hospital for upper airway manifestation and lesions of the midline structures. Rheumatology service evaluated the diagnosis of ANCA associated Vasculitis, which is a differential diagnosis of the entity known as midline destructive lesion. In all cases, the final diagnosis of T lymphoma was reached after an exhaustive histopathological study.


Subject(s)
Humans , Granulomatosis with Polyangiitis , Rheumatology , Vasculitis , Lymphoma
20.
Rev. argent. reumatolg. (En línea) ; 31(2): 45-50, jun. 2020. ilus, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1143932

ABSTRACT

El síndrome sarcoidosis-linfoma es una entidad clínica a la cual se puede llegar de distintas formas a su diagnóstico. Algunas de las mismas suelen ser atípicas. Para estos casos complejos, la tomografía por emisión de positrones (PET) combinado con un escáner de tomografía computarizada de rayos X (CT), (PET-CT) es definitorio para llegar posteriormente a la biopsia. Se presenta un caso clínico de nuestro grupo que da lugar a la revisión/puesta al día correspondiente.


Sarcoidosis-lymphoma syndrome is a clinical entity that can be diagnosed in different ways. Some of them are atypical. For these complex cases, positron emission tomography (PET) combined with an X-ray computed tomography (CT) scanner (PET-CT) is definitive for subsequent biopsy. A clinical case of our group is presented, which leads to the corresponding revision/update.


Subject(s)
Humans , Sarcoidosis , Biopsy , Positron Emission Tomography Computed Tomography , Lymphoma
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