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1.
Säo Paulo med. j ; 140(2): 310-319, Jan.-Feb. 2022. tab
Article in English | LILACS | ID: biblio-1366053

ABSTRACT

ABSTRACT BACKGROUND: Teleradiology consists of electronic transmission of radiological images from one location to another, including between countries, for interpretation and/or consultation. It is one of the most successful applications of telemedicine. Combining this methodology with ultrasound (called telesonography) can accelerate the process of making diagnoses. Despite this rationale, the quality of the evidence about the effectiveness and accuracy of teleradiology remains unknown. OBJECTIVE: To review the literature on the evidence that exists regarding use of telemedicine for ultrasound in situations of synchronous transmission. DESIGN AND SETTING: Narrative review conducted within the evidence-based health program at a federal university in São Paulo (SP), Brazil. METHODS: A search of the literature was carried out in April 2020, in the online databases MEDLINE, EMBASE, Cochrane Library, Tripdatabase, CINAHL and LILACS, for original publications in all languages. The reference lists of the studies included and the main reviews on the subject were also evaluated. RESULTS: We included ten studies that assessed procedures performed by different healthcare professionals, always with a doctor experienced in ultrasound as a distant mentor. Among these, only one study assessed disease diagnoses in relation to real patients. CONCLUSIONS: Despite the promising position of telesonography within telemedicine, no studies with reasonable methodological quality have yet been conducted to demonstrate its effectiveness.


Subject(s)
Telemedicine , Brazil , MEDLINE , Ultrasonography
2.
São Paulo; s.n; s.n; 2022. 189 p. tab, graf.
Thesis in Portuguese | LILACS | ID: biblio-1380163

ABSTRACT

A fibrilação atrial (FA) não valvar é a arritmia cardíaca mais comum em adultos, principalmente na população idosa. Para o tratamento da FA, recomenda-se a utilização de guias de prática clínica (GPCs), que são documentos que apresentam as melhores e mais atualizadas evidências para o tratamento dos pacientes acometidos por essa arritmia. Todavia, o processo de desenvolvimento dos GPCs requer recursos humanos, financeiros e tempo. Assim, a adaptação dos referidos documentos é uma opção para reduzir a duplicação de esforços e possibilitar sua adequação para uso local. O objetivo deste trabalho foi elaborar uma matriz de recomendações farmacológicas para subsidiar o processo de adaptação de GPCs utilizados no tratamento da fibrilação atrial não valvar. Para tanto, aplicou-se o método ADAPTE: revisão sistematizada de GPCs, avaliação e seleção dos GPCs de qualidade e elaboração da matriz. Foram considerados elegíveis 26 GPCs com recomendações farmacológicas para assistência primária da fibrilação atrial não valvar em adultos, publicados em inglês, espanhol ou português no período de abril de 2014 a abril de 2019 e indexados às bases de referência: MEDLINE, Embase, Cochrane Library e em 12 bases de dados específicas. A qualidade dos GPCs, foi avaliada pela aplicação do instrumento Appraisal of Guidelines for Research & Evaluarion II (AGREE II), sendo considerados de alta qualidade aqueles que apresentaram nota igual ou superior a 60 % no domínio Rigor de desenvolvimento. Todas as etapas foram realizadas por, pelo menos, 2 avaliadores e em caso de discrepância, um terceiro avaliador participou do processo. Dos 26 GPCs avaliados apenas 7 (26,9%) foram considerados de alta qualidade. A maioria dos GPCs utiliza o escore CHA2DS2-VASc, que indica a profilaxia tromboembólica em pacientes com FA não valvar a partir da pontuação 1 (fator de risco não sexual) e sugere a anticoagulação com anticoagulantes de ação direta. Houve pouca ênfase à complexidade da profilaxia de eventos tromboembólicos em idosos. Esta matriz visa contribuir para que sejam realizadas discussões e adaptações de GPCs destinado ao tratamento da FA não valvar com ênfase nas demandas e necessidades locais


Non-valvular atrial fibrillation (AF) is the most common cardiac arrhythmia in adults, especially in the elderly population. For the treatment of AF, the use of clinical practice guidelines (CPGs) is recommended, which are documents that present the best and most up-to-date evidence for the treatment of patients who are affected by this arrhythmia. However, the CPGs development process requires human, financial and time resources. However, the adaptation of documents is an option to reduce the duplication of efforts and make it possible to adapt them for any local use. The objective of this work was to elaborate a matrix of pharmacological treatment to support the process of adaptation of CPGs used in the treatment of non-valvular atrial fibrillation. Therefore, the ADAPTE method was applied: systematic review of CPGs, evaluation and selection of quality CPGs and matrix definition. Twenty-six CPGs were considered eligible with pharmacological recommendations for primary care of non-valvular atrial fibrillation valid in adults, published in English, Spanish or Portuguese from April 2014 to April 2019 and indexed to the following reference databases: MEDLINE, Embase, Cochrane Library and in 12 specific databases. The quality of the CPGs was assessed by applying the Assessment of Guidelines for Research and Assessment II (AGREE II) instrument, being considered of high those who had a grade equal to or greater than 60% in the domain Rigour of development. All steps were performed by a least 2 evaluators and in case of discrepancy, a third evaluator participated in the process. Of the 26 CPGs evaluated, only 7 (26.9%) were considered to be of high quality. Most CPGs use the CHA2DS2-VASc score, which indicates thromboembolic prophylaxis in patients with non-valvular AF from score 1 (non-sexual risk factor), and suggest anticoagulation with direct-acting anticoagulants. There was little emphasis on the complexity of prophylaxis for thromboembolic events in the elderly. This matrix aims to contribute to discussion and adaptations of CPGs for the treatment of non-valvar AF with the emphasis on local demands and needs


Subject(s)
Atrial Fibrillation/drug therapy , Practice Guidelines as Topic , Evidence-Based Medicine/classification , Disease Prevention , Systematic Reviews as Topic , Patients/classification , Primary Health Care/statistics & numerical data , World Health Organization , Risk Factors , MEDLINE , Total Quality Management/classification , Health Services Needs and Demand/classification , Libraries/classification
3.
Rev. méd. hondur ; 89(2): 142-147, jul.-dic. 2021.
Article in Spanish | LILACS, BIMENA | ID: biblio-1367317

ABSTRACT

El propósito de esta revisión fue analizar la literatura existente con el fin de identificar los principales aspectos de la en- fermedad ocasionada por el SARS-CoV-2, así como su impacto en la salud mental del adulto mayor y su relación con la mortalidad en esta población en riesgo. Se revisó la información a partir de artículos de revistas electrónicas a través de las bases de datos Pubmed, Medline, Scopus y Google Scholar para el período julio 2020 a junio 2021. Entre los aspectos relevantes se encontró da- tos alarmantes, los pacientes con comorbilidades en este grupo de edad tenían 6 veces más probabilidad de ser hospitalizados y 12 veces más probabilidad de morir que una persona sin comorbili - dades. La salud mental es un importante factor en esta pandemia, se ha demostrado deterioro en estado general y enfermedades mentales debido a la ansiedad y aislamiento social secundario a la pandemia en este grupo...(AU)


Subject(s)
Humans , Aged , Aged, 80 and over , Adult/psychology , SARS-CoV-2 , COVID-19/diagnosis , Mental Health , MEDLINE , Periodical
4.
Arq. Asma, Alerg. Imunol ; 5(3): 213-222, jul.set.2021. ilus
Article in Spanish | LILACS | ID: biblio-1399208

ABSTRACT

El propósito de este trabajo fue revisar la literatura científica que evalúa la eficacia y seguridad de las monoterapias de fexofenadina y montelukast, la terapia combinada (fija o en asociación) de montelukast - fexofenadina, así como de montelukast con otros antihistamínicos de segunda generación en el tratamiento de la rinitis alérgica. Se realizó una estrategia de búsqueda bibliográfica de múltiples etapas, en donde se identificaron estudios basados en ensayos clínicos y estudios no aleatorizados (ensayo controlado no aleatorizado, controlado antes-después, de series de tiempo interrumpidas, con controles históricos, de cohorte, de casos y controles, estudio transversal, y series de casos) en pacientes con rinitis alérgica, en las bases de datos MEDLINE/ PubMed, Scopus, Web of Science, Biblioteca Cochrane, Redalyc y Colección BVS y debido a la cantidad de resultados obtenidos se incluyó la búsqueda en Hinari. Con base en esta revisión se concluye que las combinaciones de antihistamínicos de segunda generación y antagonistas de leucotrienos y, en particular, la combinación fija de fexofenadina ­ montelukast es eficaz, segura y favorece la adherencia al tratamiento, y a largo plazo también ayuda a alcanzar el objetivo terapéutico.


The purpose of this work was to review the scientific literature that evaluates the efficacy and safety of monotherapies of fexofenadine and montelukast, the combined therapy (fixed-dose or separate drug combinations) of montelukast-fexofenadine, as well as the use of montelukast together with other second-generation antihistamines in the treatment of allergic rhinitis. A multistage literature search strategy was designed, including clinical trials and non-randomized studies (non-randomized controlled trial, controlled before-after study, interrupted time series study, historical control study, cohort study, case-control study, crosssectional study, and case series) evaluating patients with allergic rhinitis. The databases MEDLINE/PubMed, Scopus, Web of Science, Cochrane Library, Redalyc, BVS Collection, and, due to the number of results obtained, Hinari were included. Based on this review, the conclusion is that the combinations of secondgeneration antihistamines with leukotriene antagonists and, in particular, the fixed combination of fexofenadine-montelukast are effective, safe and promote treatment adherence. In the long term, they also help achieve therapeutic goals.


Subject(s)
Humans , Safety , Efficacy , Combined Modality Therapy , Leukotriene Antagonists , Rhinitis, Allergic , Histamine Antagonists , Patients , Therapeutics , MEDLINE
5.
Rev. colomb. psiquiatr ; 50(1): 34-38, Jan.-Mar. 2021. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1251630

ABSTRACT

RESUMEN Introducción: El conocimiento de la frecuencia de comportamientos zoofílicos en la población general es escaso. Objetivo: Revisar casos, series de casos y estudios de prevalencia de zoofilia en adultos de la población general. Métodos: Se realizó una revisión en las bases de datos de MEDLINE, a través de PubMed, Scopus y la Biblioteca Virtual en Salud de publicaciones desde enero de 2000 hasta diciembre de 2017. Resultados: Se revisaron 13 trabajos (10 informes de casos, 2 series de casos y 1 estudio transversal). Entre los casos se describió a 12 pacientes; las series de casos sumaron a 1.556 personas y el estudio transversal incluyó a 1.015 participantes e informó de una prevalencia de comportamientos zoofílicos del 2%. Conclusiones: Es escasa la información sobre la prevalencia de comportamientos zoofílicos en la población general. Es probable que internet permita investigar mejor estos comportamientos en los próximos años.


ABSTRACT Background: Information about the frequency of zoophilic behaviour in the general population is scarce. Objective: To review cases, case series and prevalence studies of zoophilia in adults in the general population. Methods: A review of publications was carried out in MEDLINE via PubMed, Scopus and the Biblioteca Virtual en Salud [Virtual Health Library] ranging from January 2000 to December 2017. Results: Thirteen papers were reviewed (ten case reports, two case series and one cross-sectional study). Twelve patients were described, the case series totalled 1,556 people and the cross-sectional study included 1,015 participants and reported a prevalence of zoophilic behaviour of 2%. Conclusions: Information on the prevalence of zoophilic behaviour in the general population is limited. The Internet will probably be a valuable tool for further investigating these behaviours in coming years.


Subject(s)
Humans , Male , Female , Sexual Dysfunctions, Psychological , Libraries, Digital , Population , Volition , Cross-Sectional Studies , MEDLINE , Internet , PubMed , Methods
6.
Rev. colomb. psiquiatr ; 49(3): 187-193, jul.-set. 2020. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1149825

ABSTRACT

RESUMEN Introducción: El síndrome de Cotard es de rara aparición en la clínica psiquiátrica. Debido a esto, la información actual se basa principalmente en reportes y series de casos. Objetivo: Analizar las características psicopatológicas y la agrupación de los síntomas de los casos de síndrome de Cotard reportados en la literatura médica. Métodos: Se realizó en la base de datos MEDLINE/PubMed una búsqueda sistemática de la literatura de todos los casos de síndrome de Cotard reportados desde 2005 hasta enero de 2018. Se recolectaron variables demográficas y las características clínicas de cada caso. Se realizó un análisis factorial exploratorio de los síntomas. Resultados: La búsqueda identificó 86 artículos, de los cuales 69 eran potencialmente relevantes. Luego de la revisión de los textos completos, se seleccionaron 55 artículos para la revisión sistemática, entre los cuales se hallaron 69 casos. En el grupo de más edad con síndrome de Cotard fueron más frecuentes los diagnósticos de depresión mayor (p < 0,001) y trastorno mental orgánico (p = 0,004). El análisis factorial exploratorio arrojó 3 factores: depresión psicótica, en la que se incluye a los pacientes con delirios de culpa (0,721), ideas suicidas (0,685), delirios de condena (0,662), delirio nihilista del cuerpo (0,642), depresión (0,522) y delirios hipocondriacos (0,535); delirante-alucinatorio, con pacientes que sufrían delirio de inmortalidad (0,566), alucinaciones visuales (0,545) y delirio nihilista de la existencia (0,451), y mixto, con pacientes que sufrían delirio nihilista de los conceptos (0,702), ansiedad (0,573) y alucinaciones auditivas (0,560). Conclusiones: La psicopatología del síndrome de Cotard es más compleja que la simple asociación con el delirio de estar muerto, ya que abarca una estructura factorial organizada en 3 factores.


ABSTRACT Introduction: Cotard's syndrome is a rare psychiatric condition. As a result, current information is mainly based on reports and case series. Objective: To analyse the psychopathological characteristics and the grouping of the symptoms of the Cotard's syndrome cases reported in the medical literature. Methods: A systematic review of the literature of all reported cases of Cotard's syndrome from 2005 to January 2018 was performed in the MEDLINE/PubMed database. Demographic variables and clinical characteristics of each case were collected. An exploratory factor analysis of the symptoms was performed. Results: The search identified 86 articles, of which 69 were potentially relevant. After reviewing the full texts, 55 articles were selected for the systematic review, in which we found 69 cases. We found that the diagnosis of major depression (P < 0.001) and organic mental disorder (P =0.004) were more frequent in the older group with Cotard's syndrome. An exploratory factor analysis extracted 3 factors: psychotic depression, in which it includes patients with delusions of guilt (0.721), suicidal ideas (0.685), delusions of damnation (0.662), nihilistic delusions of the body (0.642), depression (0.522), and hypochondriacal delusions (0.535); delusive-hallucinatory, with patients who presented delusions of immortality (0.566), visual hallucinations (0.545) and nihilistic delusions of existence (0.451), and mixed, with patients who presented nihilistic delusions of concepts (0.702), anxiety (0.573), and auditory hallucinations (0.560). Conclusions: The psychopathology of Cotard's syndrome is more complex than the simple association with the delusion of being dead, since it encompasses a factorial structure organised into 3 factors.


Subject(s)
Humans , Male , Female , Psychopathology , Syndrome , Factor Analysis, Statistical , Mental Disorders , Anxiety , MEDLINE , Neurocognitive Disorders , Delirium , Delusions , Depression , Suicidal Ideation , Hallucinations
7.
Rev. cuba. angiol. cir. vasc ; 21(2): e131, mayo.-ago. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126381

ABSTRACT

Introducción: La Revista Cubana de Angiología y Cirugía Vascular tiene como misión contribuir al desarrollo de la especialidad, mediante la publicación de artículos científicos nacionales y extranjeros de alta calidad. Objetivo: Evaluar la visibilidad de la Revista Cubana de Angiología y Cirugía Vascular en el período 2014-2018. Métodos: Se realizó un estudio descriptivo, observacional y retrospectivo sobre la visibilidad alcanzada en el período 2014-2018. La muestra estuvo constituida por todos los tipos de artículos publicados en la Revista Cubana de Angiología y Cirugía Vascular en la etapa estudiada y se tomó como referencia la base de datos SciELO regional. Resultados: La Revista Cubana de Angiología y Cirugía Vascular entre 2014 y 2018 publicó un total de 110 trabajos científicos con una frecuencia semestral. Los años 2015 y 2017 fueron los de mayor cantidad de publicaciones, mientras que en 2014 y 2018 se contribuyó, con más publicaciones, con otras revistas cubanas. Los artículos originales resultaron la modalidad que más aportó con un total de 45, equivalente a un 40,9 por ciento. Conclusiones: La revista podría mejorar su visibilidad si se indexara en más bases de datos como Scopus y Medline, y se introdujera en redes sociales científicas como LinkedIn y Research Gate(AU)


Introduction: The Revista Cubana de Angiología y Cirugía Vascular [Cuban Journal of Angiology and Vascular Surgery] has the mission of contributing to the development of the specialty, by publishing high-quality national and foreign scientific articles. Objective: To assess the visibility of the Cuban Journal of Angiology and Vascular Surgery in the period from 2014 to 2018. Methods: A descriptive, observational and retrospective study was carried out about the visibility achieved in the period from 2014 to 2018. The sample consisted of all the types of articles published in the Cuban Journal of Angiology and Vascular Surgery during the stage studied. The regional database SciELO was used as a reference. Results: The Cuban Journal of Angiology and Vascular Surgery, between 2014 and 2018, published a total of 110 scientific papers in a biannual frequency. The years 2015 and 2017 were the ones with the greatest amounts of publications, while, in 2014 and 2018, other Cuban journals were contributed with more publications. Original articles are the modality that contributed the most, with a total of 45, accounting for 40.9 percent. Conclusions: The journal could improve its visibility if it were indexed in more databases, such as Scopus and Medline, and if it were introduced in scientific social media, such as LinkedIn and Research Gate(AU)


Subject(s)
Humans , Periodicals as Topic , Total Quality Management , Social Networking , MEDLINE
8.
Arq. Asma, Alerg. Imunol ; 4(2): 172-180, abr.jun.2020. ilus
Article in Portuguese | LILACS | ID: biblio-1381903

ABSTRACT

Compreender os mecanismos imunopatológicos envolvidos na evolução da COVID-19 é um desafio para a ciência mundial. A observação da existência de formas clínicas diferentes da doença, podendo ocorrer desde manifestações leves até formas graves, demonstra a complexidade da resposta imune desenvolvida frente à infecção pelo SARS-CoV-2. Nesta revisão da literatura, utilizamos as bases de dados PubMed, MEDLINE, LILACS, SciELO a partir de dezembro de 2019, quando surgiram os primeiros casos da doença. A relação entre as diferentes formas clínicas da COVID-19 com o desenvolvimento da resposta imune foi amplamente discutida. As diferenças da evolução da COVID-19 em crianças e idosos foram avaliadas focalizando aspectos da resposta imune que podem conferir prognóstico favorável ou risco de desenvolvimento de formas clínicas graves. Particularidades da infecção pelo SARS-CoV-2 em pacientes com imunossupressão e em portadores de asma foram analisadas. Os mecanismos imunopatológicos envolvidos no desenvolvimento das formas graves da COVID-19 foram abordados com ênfase no fenômeno "tempestade de citocinas".


Understanding the immunopathological mechanisms involved in the evolution of COVID-19 is a challenge for science worldwide. The observed existence of several clinical forms of the disease with mild to severe manifestations demonstrates the complexity of the immune response to SARS-CoV-2 infection. In this literature review, we searched the PubMed, MEDLINE, LILACS, SciELO databases for studies published after December 2019, when the first cases of the disease were described. The relationship between the different clinical forms of COVID-19 and the development of immune response was widely discussed. The differences in the evolution of COVID-19 in children and elderly were evaluated focusing aspects of the immune response that may confer favorable prognosis or risk of developing severe clinical forms. Particularities of SARS-CoV-2 infection in patients with immunosuppression and in asthma patients were analyzed. The immunopathological mechanisms involved in the development of severe forms of COVID-19 were addressed, with emphasis on the cytokine storm phenomenon.


Subject(s)
Humans , SARS-CoV-2 , COVID-19 , Immunity , Patients , Asthma , MEDLINE , Immunosuppression Therapy , PubMed , Cytokine Release Syndrome
9.
Psicol. ciênc. prof ; 40: e180896, jan.-maio 2020.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1128954

ABSTRACT

Atualmente, aponta-se que a prevalência de crianças diagnosticadas com Transtorno do Espectro Autista é de uma criança para cada sessenta e oito. Diante disso, aventa-se a possibilidade de uma epidemia. Este trabalho tem como objetivo tecer considerações a respeito do aumento de crianças diagnosticadas com Transtorno do Espectro Autista contemporaneamente. A partir de uma investigação teórica, procurou-se conjecturar hipóteses para esse fenômeno e suas devidas implicações para a prática clínica do psicólogo. Foram realizadas pesquisas em bases de dados como PubMed, Medline e Biblioteca Virtual em Saúde ­ Psicologia Brasil. Os dados epidemiológicos encontrados apontaram para um aumento significativo do diagnóstico nos últimos anos, o que provocou uma questão sobre essa possível epidemia. Esses achados nos fizeram supor que tal aumento se edifique pela articulação entre as perspectivas psiquiátrica e social. A discussão dessa hipótese sustenta, então, que a prática do psicólogo diante da demanda referente ao sofrimento na infância deve ser pautada por um posicionamento ético e por uma clínica atenta ao cuidado...(AU)


Currently, estimates point to the prevalence of children diagnosed with Autism Spectrum Disorder (ASD) of one child every sixty-eight. The possibility of an epidemic is considered. This study makes some considerations about the increase in children diagnosed with ASD in the last decades. As a theoretical investigation, we thought of hypotheses for this phenomenon and its implications for the psychology clinical practice and searched databases such as Pubmed, Medline and BVS-PSI. The epidemiological data found indicated a significant increase in diagnosis in recent years, which raised a question about this possible epidemic. These findings have led us to suppose that such an increase is built by the articulation between the psychiatric and social perspectives. Our hypothesis holds that the psychologist's practice for suffering in childhood should be guided by an ethical stance and a clinic attentive to care...(AU)


Currently, estimates point to the prevalence of children diagnosed with Autism Spectrum Disorder (ASD) of one child every sixty-eight. The possibility of an epidemic is considered. This study makes some considerations about the increase in children diagnosed with ASD in the last decades. As a theoretical investigation, we thought of hypotheses for this phenomenon and its implications for the psychology clinical practice and searched databases such as Pubmed, Medline and BVS-PSI. The epidemiological data found indicated a significant increase in diagnosis in recent years, which raised a question about this possible epidemic. These findings have led us to suppose that such an increase is built by the articulation between the psychiatric and social perspectives. Our hypothesis holds that the psychologist's practice for suffering in childhood should be guided by an ethical stance and a clinic attentive to care...(AU)


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Psychology , Child , MEDLINE , PubMed , Libraries, Digital , Diagnosis , Epidemics , Autism Spectrum Disorder
10.
Arq. Asma, Alerg. Imunol ; 4(1): 72-77, jan.mar.2020. ilus
Article in Portuguese | LILACS | ID: biblio-1381787

ABSTRACT

O objetivo deste trabalho é fazer uma revisão atual do tratamento de alguns tipos de câncer com imunoterapia e inibidores do checkpoint imunológico. As fontes de dados incluíram artigos originais, revisões e publicações indexados nos bancos de dados PubMed, MEDLINE, LILACS, SciELO e publicações online nos últimos 20 anos. Os checkpoints imunológicos normalmente impedem o organismo de montar uma resposta imune contra células normais. Alguns tipos de câncer podem adquirir estes checkpoints de tal forma que estas células tumorais não são reconhecidas pelo sistema imune, e isto impede que ele seja ativado. A inibição dos checkpoints imunológicos pode melhorar a sobrevida de pacientes com malignidades avançadas. Isto inclui melanoma maligno, carcinoma renal, linfoma e câncer pulmonar de células não pequenas. Uma extraordinária quantidade de investigações pré-clínicas e clínicas estão explorando o potencial terapêutico das moléculas coestimulatórias positivas e negativas. Aqui, nós revisamos o estado atual do nosso conhecimento dos mecanismos co-estimulatórios da célula T e a inibição dos checkpoints, primariamente do CTLA-4 e do PD-1.


This paper aims to review current treatment of some types of cancer with immunotherapy and immune checkpoint inhibitors. Data sources included original articles, reviews and related texts published over the past 20 years in PubMed, MEDLINE, LILACS and SciELO databases and other online publications. Immune checkpoints normally prevent the body from developing an immune response against healthy cells. Some types of cancer may acquire these checkpoints so that the tumor cells are not recognized by the immune system, preventing it from being activated. Immune checkpoint inhibitors may improve the survival of some patients with advanced malignant tumors, including malignant melanoma, renal cell carcinoma, lymphoma and non-small cell lung cancer. An extraordinary amount of preclinical and clinical investigation is exploring the therapeutic potential of negative and positive costimulatory molecules. Herein, we review the current status of our understanding of T-cell costimulatory mechanisms and checkpoint inhibitors, primarily of CTLA-4 and PD-1.


Subject(s)
Humans , Carcinoma, Renal Cell , T-Lymphocytes , Carcinoma, Non-Small-Cell Lung , Immune Checkpoint Inhibitors , Immunotherapy , Lymphoma , Melanoma , Patients , Survival , Therapeutics , Cells , MEDLINE , PubMed , Immune System , Immunity , Neoplasms
11.
Arq. Asma, Alerg. Imunol ; 3(3): 275-282, jul.set.2019. ilus
Article in Portuguese | LILACS | ID: biblio-1381257

ABSTRACT

O objetivo deste artigo foi avaliar a prevalência e fatores de risco para sibilância recorrente e asma em lactentes. Foi realizada pesquisa de artigos originais, revisões, consensos indexados e publicações on-line, nos últimos 15 anos, nos bancos de dados PubMed, MEDLINE, LILACS e SciELO. Conhecer a prevalência de sibilância recorrente e os fatores a ela associados é imprescindível, visto a sibilância recorrente ser uma das principais manifestações clínicas da asma na infância, sendo inclusive considerada por alguns autores como sinônimo desta doença, somado ao fato de que alguns dos fatores associados à sibilância no primeiro ano de vida também o são ao desenvolvimento de asma em crianças e adolescentes. A realização e aprofundamento de pesquisas sobre a sibilância e a asma na infância se fazem necessárias, e podem colaborar com a implantação de políticas públicas de saúde e programas educacionais objetivando o diagnóstico precoce de asma, e a adoção de medidas preventivas que favoreçam seu controle e evolução.


The objective of this study was to evaluate the prevalence and risk factors of recurrent wheezing and asthma in infants. MEDLINE (via PubMed), LILACS, and SciELO databases were searched for original articles, reviews, indexed guidelines, and online resources published in the past 15 years. It is essential to know the prevalence of recurrent wheezing and its associated factors, since recurrent wheezing is one of the main clinical manifestations of childhood asthma, being considered by some authors a synonym of this disease. Also, some factors associated with wheezing in the first year of life may influence the development of asthma in children and adolescents. Further research on wheezing and asthma in childhood is needed and may contribute to the implementation of public health policies and educational programs aimed at the early diagnosis of asthma and to the adoption of preventive measures to improve asthma control and reduce disease burden.


Subject(s)
Humans , Infant , Asthma , Respiratory Sounds , Signs and Symptoms , Prevalence , Risk Factors , MEDLINE , PubMed , Early Diagnosis , LILACS
12.
Rev. colomb. cardiol ; 26(4): 185-197, jul.-ago. 2019. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1092925

ABSTRACT

Resumen Introducción: La falla cardiaca asociada a deficiencia de hierro se relaciona directamente con disminución de parámetros funcionales y, por ende, con deterioro de la calidad de vida y pobre pronóstico de los pacientes que la padecen. Se ha encontrado que la corrección de la deficiencia de hierro mejora a corto plazo la clase funcional y otros parámetros de la enfermedad. Objetivo: Evaluar la eficacia y la seguridad del uso de hierro en el tratamiento de la falla cardiaca. Métodos: De seleccionaron ensayos clínicos que evaluaran el uso de hierro en administración intravenosa u oral vs. placebo en el contexto de pacientes con falla cardíaca y a su vez se eligieron pacientes que concomitantemente sufrieran anemia ferropénica. En la búsqueda se incluyeron bases de datos como MEDLINE (PubMed), Embase, Cochrane Central Register of Clinical trials (CENTRAL), LILACS y WPRIM. Resultados: De 10.729 títulos obtenidos 6 fueron elegibles con 835 pacientes, de los cuales 520 fueron tratados con terapia férrica y 315 con placebo o terapia convencional de falla cardiaca. Debido a la heterogeneidad de los resultados no fue posible hacer un metaanálisis. Conclusión: Se identificó mejoría significativa en múltiples parámetros evaluados, tales como el test de caminata de 6 minutos, clase funcional de la New York Heart Association, consumo máximo de oxígeno (VO2 máx.) y valoración global subjetiva. Por consiguiente, la terapia férrica es una opción segura y eficaz en el manejo de pacientes con falla cardiaca ya que mejora significativamente su capacidad funcional, calidad de vida y múltiples parámetros paraclínicos.


Abstract Introduction: Heart failure combined with iron deficiency is directly related with the reduction in functional parameters and, as consequence, with a deterioration in the quality of life and poor prognosis in the patients that suffer from it. It has been found that correction of the iron deficiency improves the functional class and other parameters of the disease in the short-term. Objective: To evaluate the efficacy and safety of the use of iron in the treatment of heart failure. Methods: Clinical trials were selected that evaluated the use of administering intravenous or oral iron vs. placebo in the context of patients with cardiac failure and at the same time, patients were selected that concomitantly suffered from iron deficiency anaemia. The search was made in data bases such as MEDLINE (PubMed), Embase, Cochrane Central Register of Clinical trials (CENTRAL), LILACS and WPRIM. Results: Of the 10,729 articles obtained, only 6 were eligible with 835 patients, of which 520 were treated with iron therapy and 315 with a placebo or conventional heart failure therapy. Due to the heterogeneity of the results, it was not possible to perform a meta-analysis. Conclusion: A significant improvement was identified in several of the parameters evaluated, such as the 6-minute walk test, the New York Heart Association functional class, maximum oxygen uptake (VO2 max.), and an overall subjective evaluation. This showed that iron therapy is a safe and effective option in the management of patients with heart failure since there was a significant improvement in their functional capacity, quality of life, and several para-clinical parameters.


Subject(s)
Humans , Male , Aged , Heart Failure , Quality of Life , MEDLINE , Anemia, Iron-Deficiency , PubMed , LILACS
13.
Rev. colomb. psiquiatr ; 48(2): 105-126, ene.-jun. 2019. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1042854

ABSTRACT

RESUMEN Introducción: La transferencia del conocimiento (KT) corresponde no solo a una serie de accio nes finales en áreas de divulgación, sino a la identificación de estrategias para la realización de este proceso. Objetivo: Evaluar la efectividad de estrategias de KT en lenguaje audiovisual comparadas con otros lenguajes para mejorar los desenlaces en salud de la población general. Métodos: Se realizó una búsqueda en MEDLINE, CENTRAL, PsycARTICLES, WHO International Clinical Trials Registry Platform, EMBASE y LILACS. Resultados: Se incluyeron 63 estudios; se observó gran variabilidad en las poblaciones de estudio, así como en los lenguajes comparados con el lenguaje audiovisual y los instru mentos de medición. Los estudios tienen alto riesgo de sesgo y la calidad de la evidencia identificada no permite llegar a una conclusión respecto a la efectividad de los lenguajes evaluados en KT. Conclusiones: Se identifican diferentes lenguajes que pueden emplearse para transferir cono cimientos. Se evidencia que el conocimiento y los efectos producidos por la intervención disminuyen a medida que avanza el tiempo, independientemente del tipo de lenguaje empleado. Por lo tanto, es el tiempo es un punto importante a tener en cuenta en este tipo de intervenciones.


ABSTRACT Background: Knowledge translation (KT) not only encompasses a series of final actions in areas of dissemination, but also the identification of strategies for the implementation of this process. Objective: To evaluate the effectiveness of KT strategies in audiovisual language compared with other languages to improve health outcomes in the general population. Methods: We performed a search in MEDLINE, CENTRAL, PsycARTICLES, the WHO Interna tional Clinical Trials Registry Platform, EMBASE and LILACS. Results: We included 63 studies encompassing a broad range of study populations, languages that were compared to audiovisual language and measurement scales for outcomes. These studies presented a high risk of bias and the quality of evidence was not sufficient to draw conclusions about the effectiveness of the evaluated languages for knowledge translation. Conclusions: We identified different languages that could be used in knowledge translation. The knowledge and the effects produced as a result of the strategy diminish as time pro gresses, regardless of the type of language used. This is an important point to consider when implementing this type of strategy.


Subject(s)
Humans , Pregnancy , Infant , Adolescent , Adult , Effectiveness , Knowledge , Registries , MEDLINE , Health Strategies , Total Quality Management , Translational Research, Biomedical , LILACS , Methods
14.
Arq. Asma, Alerg. Imunol ; 3(2): 111-122, abr.jun.2019. ilus
Article in Portuguese | LILACS | ID: biblio-1381175

ABSTRACT

A deficiência de anticorpos específicos antipolissacarídeos é um dos erros inatos da imunidade predominantemente de anticorpos, destacando-se entre os defeitos mais frequentes. É caracterizada por uma permanência de imaturidade da resposta imunológica a antígenos polissacarídeos, estando normais linfócitos B, classes e subclasses de imunoglobulinas. O paciente apresenta maior suscetibilidade a infecções por bactérias encapsuladas, especialmente Streptococcus pneumoniae e Haemophilus influenzae. As principais manifestações clínicas são otites, sinusites, traqueobronquites e pneumonias de repetição; pode haver meningite pneumocócica e septicemia. A investigação é feita por titulação de anticorpos antipolissacarídeos antes e após a aplicação da vacina pneumocócica não conjugada. Até dois anos, há imaturidade fisiológica desse setor da imunidade, por isso, o diagnóstico não pode ser feito antes desta idade. O tratamento, além de antibiótico precoce em vigência de quadros infecciosos, inclui antibióticos profiláticos, aplicação de vacina conjugada com proteínas e/ou reposição de imunoglobulina humana endovenosa ou subcutânea. O diagnóstico e o tratamento precoce melhoram a qualidade de vida do paciente, diminuindo o risco de sequelas e até de óbito por infecção, e quando não são precoces, é possível que haja sequelas como bronquiectasias, hipoacusia ou danos neurológicos.


Specific polysaccharide antibody deficiency is an inborn error of immunity predominantly affecting antibodies, being one of the most frequent primary immunodeficiencies of childhood. It is characterized by persistent immaturity of the immune response to polysaccharide antigens, with normal levels of B lymphocytes, immunoglobulin classes and subclasses. Patients are more susceptible to infections by encapsulated bacteria, especially Streptococcus pneumoniae and Haemophilus influenzae. The main clinical manifestations are recurrent otitis, sinusitis, tracheobronchitis and pneumonia; there may be pneumococcal meningitis and septicemia. The investigation is done by dosages of polysaccharide antibodies before and after unconjugated pneumococcal vaccination. As this area of immunity is physiologically immature until two years of age, diagnosis cannot be made earlier. Treatment, in addition to antibiotics as soon as infections are detected, includes prophylactic antibiotic therapy, use of pneumococcal vaccine conjugated to protein and/or replacement of intravenous or subcutaneous human immunoglobulin. Early diagnosis and treatment improve patients' quality of life, reducing the risk of sequelae and even death from infection, while lack of early measures can lead to sequelae such as bronchiectasis, hearing loss and neurological damage.


Subject(s)
Humans , Polysaccharides , Streptococcus pneumoniae , B-Lymphocytes , Haemophilus influenzae , Pneumococcal Vaccines , Antibodies , Otitis , Patients , Pneumonia , Quality of Life , Signs and Symptoms , Sinusitis , Therapeutics , Bacterial Infections , Bronchiectasis , Immunoglobulin G , Immunoglobulins , MEDLINE , Immunoglobulins, Intravenous , Sepsis , Death , Early Diagnosis , LILACS , Immunity , Anti-Bacterial Agents , Antigens
15.
Arq. Asma, Alerg. Imunol ; 3(2): 123-132, abr.jun.2019. ilus
Article in Portuguese | LILACS | ID: biblio-1381179

ABSTRACT

Na última década, avanços consideráveis na compreensão da patogênese da dermatite atópica têm pavimentado a via de um número de novos tratamentos. A melhora da imunoterapia subcutânea com alérgenos e a introdução da imunoterapia sublingual deram lugar à prospecção de sua aplicação para adultos e crianças portadoras de dermatite atópica. Esta revisão apresenta resultados das pesquisas científicas, análises sistemáticas e metanálises que confirmam a eficácia clínica da imunoterapia com alérgenos para pacientes com dermatite atópica de curso moderado ou grave, que apresentam sensibilização a aeroalérgenos. Apresentamos também novas informações de como usar os bioterapêuticos que estão levando a tentativas mais eficazes de tratamento. A esperança é de que estes novos biológicos ou antagonistas de pequenas moléculas, que têm alta especificidade para as moléculas-alvo, possam diminuir os efeitos indesejáveis causados pelos agentes imunossupressivos sem um alvo específico, como os observados pelas drogas de ampla ação biológica. Com o desenvolvimento e subsequentemente com a aprovação dos bioterapêuticos pelas agências reguladoras, nós começamos a ver uma revolução clínica e terapêutica no tratamento da dermatite atópica. As fontes de dados incluíram artigos originais, revisões e publicações indexados nos bancos de dados PubMed, MEDLINE, LILACS, SciELO e publicações on-line nos últimos 15 anos. Como resultado, uma nova era no tratamento de pacientes com doenças crônicas graves está em andamento na nossa especialidade. O uso de imunoterapia subcutânea, imunoterapia sublingual e bioterapêuticos para dermatite atópica prometem grande precisão e efetividade na medicina personalizada.


In the past decade, considerable advances in our understanding of the pathogenesis of atopic dermatitis have paved the way for a number of new treatments. The improvement of subcutaneous allergen immunotherapy and the introduction of sublingual immunotherapy provided prospects of their administration both for adults and children suffering from atopic dermatitis. This review includes results of scientific studies, systematic reviews and metaanalyses that confirm the clinical efficacy of allergen immunotherapy for patients with moderate and severe atopic dermatitis who are sensitive to aeroallergens. Also, new information on how the use of biotherapeutics is leading to more effective approaches to treatment is presented. Hopefully these new biologicals or small molecule antagonists, which have high specificity for their target molecules, will decrease the undesirable off-target effects commonly observed with current immunosuppressive agents that are characterized by broad biological actions. With the development and subsequent regulatory approval of biotherapeutic agents, a clinical and therapeutic revolution has begun in the treatment of atopic dermatitis. Data sources included original articles, reviews and related texts published over the past 15 years, retrieved from PubMed, MEDLINE, LILACS and SciELO databases and other online publications. As a result, a new era in the treatment of patients with severe chronic diseases has been observed in our specialty. The use of subcutaneous allergen immunotherapy, sublingual immunotherapy and biotherapeutics for atopic dermatitis promises greater precision and effectiveness in a personalized medicine.


Subject(s)
Humans , Dermatitis, Atopic , Precision Medicine , Sublingual Immunotherapy , Immunotherapy , Patients , Therapeutics , Biological Products , Allergens , MEDLINE , Sensitivity and Specificity , Desensitization, Immunologic , Treatment Outcome , PubMed , LILACS , Antibodies, Monoclonal
16.
Arq. Asma, Alerg. Imunol ; 3(2): 139-142, abr.jun.2019. ilus
Article in Portuguese | LILACS | ID: biblio-1381184

ABSTRACT

Metilclorotiazolinona e metilisotiazolinona (MCI/MI) são os ingredientes ativos no Kathon CG®, um conservante de cosméticos no mercado desde os anos 80. Eles aparecem numa mistura de conservantes na proporção de 3:1. Metilisotiazolinona (MI) isolada tinha sido aprovada como conservante desde 2005, uma vez que foi considerada menos sensibilizante comparado à porção clorada. Entretanto, ela tem sido usada numa concentração muito maior para ser efetiva, e isso tem causado a atual epidemia de alergia a essa substância. O objetivo dessa revisão foi examinar o atual surto de casos de alergia de contato a metilisotiazolinona (MI) no mundo, um fenômeno que tem sido observado em vários países, inclusive no Brasil. As fontes de dados incluíram os principais artigos originais e revisões indexadas nos bancos de dados PubMed, MEDLINE, LILACS e SciELO que foram publicadas nos últimos anos. Os resultados mostram elevado grau de positividade de testes de contato tanto à associação MCI/MI quanto à MI isolada, e significativo aumento da prevalência de alergia a esta substância nos últimos anos. Em conclusão, alertamos que devemos estar atentos a esse importante conservante. Salientamos que a associação MCI/MI nos testes pode não diagnosticar casos de alergia à MI. Apesar dessa substância isolada não se encontrar na bateria padrão brasileira, a pesquisa de sua sensibilidade é fundamental.


Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are the active ingredients in Kathon CG®, a cosmetic preservative available in the market since the 80s. MCI and MI are mixed in a ratio 3:1. MI alone was approved for use as a preservative in 2005, as it was considered a less sensitizing agent compared to chlorine. However, it has been used at a much higher concentration to be effective and this has caused the current epidemic of allergy to this substance. This review aimed to examine the current outbreak of cases of contact allergy to MI observed in several countries, including Brazil. Data sources were major original articles and reviews indexed in PubMed, MEDLINE, LILACS and SciELO databases and published in recent years. The results showed a high rate of positive tests for allergy both to MCI/MI combination and to MI alone, as well as a significant increase in the prevalence of allergy to this substance in recent years. In conclusion, this common preservative requires attention. Importantly, MCI/MI combination tests may not diagnose cases of allergy to MI alone. Although this substance is not found alone in the Brazilian standard battery, research on its sensitivity is essential.


Subject(s)
Humans , Cosmetics , Dermatitis, Contact , Hypersensitivity , Tinea , Prevalence , MEDLINE , Sensitivity and Specificity , LILACS
18.
Rev. colomb. anestesiol ; 47(1): 49-56, Jan.-Mar. 2019. tab, graf
Article in English | LILACS, COLNAL | ID: biblio-985434

ABSTRACT

Abstract Introduction: Heart failure is a chronic, progressive, prevalent disease, with a high impact on health systems and on the quality of life of patients and families. Dyspnea is a common symptom and management with opioids has been proposed. Objective: To conduct a systematic review of the literature pertaining to the use of opioids for the management of dyspnea in patients with stable chronic heart failure, functional class New York Heart Association (NYHA) II, III, or IV. Materials and methods: A systematic review was conducted in the MEDLINE, Embase, Cochrane, OVID, LILACS, and PROSPERO databases of articles published in 5 languages between January 1, 1995 and July 31, 2018. Studies describing the administration of any type of opioid for the management of dyspnea in patients with stable chronic heart failure NYHA II, III, or IV were included. Results: Four clinical trials were obtained for the final analysis with a total number of 70 patients, describing opioid administration for the management of dyspnea in patients with stable chronic heart failure, NYHA II, III, or IV. Conclusion: In adult patients with compensated chronic heart failure under optimum treatment, there is low-quality evidence that shows benefit with the use of opioids for the management of dyspnea. For a stronger recommendation, controlled, randomized studies with a larger number of subjects are required.


Resumen Introducción: La insuficiencia cardiaca es una enfermedad crónica, progresiva, prevalente, con un alto impacto en los sistemas de salud y en la calidad de vida de los pacientes y sus familias, la disnea es un síntoma común y se ha planteado el uso de opioides para su control. Objetivo: Revisión sistemática de la literatura sobre el uso de opioides en el manejo de la disnea en pacientes con insuficiencia cardiaca crónica estable con clase funcional NYHA II, III o IV. Materiales y métodos: Se realizó una revisión sistemática de los artículos encontrados en las bases de datos MEDLINE, Embase, Cochrane, OVID, LILACS, PROSPERO a partir del 1 de enero del 1995 hasta el 31 de julio del 2018, publicados en cinco idiomas. Se incluyeron aquellos estudios en los cuales se describe la administración de cualquier tipo de opioide para el manejo de la disnea en pacientes con insuficiencia cardiaca crónica estable, NYHA II, III o IV. Resultados: Se incluyeron cuatro ensayos clínicos para el análisis final, con un numero total de 70 pacientes, en los cuales se describe la administración de opioides para el manejo de la disnea en pacientes con insuficiencia cardiaca crónica estable, NYHA II, III, o IV. Conclusiones: En pacientes adultos con insuficiencia cardiaca crónica compensada en tratamiento óptimo, existe evidencia de baja calidad que muestra beneficio para el manejo de la disnea con opioides, deben realizarse estudios aleatorizados controlados con una cantidad de individuos mayor para poder generar una recomendación más fuerte.


Subject(s)
Humans , Quality of Life , Heart Failure , Analgesics, Opioid , Review Literature as Topic , MEDLINE , Alkalies , LILACS
19.
Arq. ciências saúde UNIPAR ; 23(1): 41-47, jan-abr. 2019.
Article in Portuguese | LILACS | ID: biblio-979973

ABSTRACT

O câncer possui inúmeras implicações epidemiológicas, sociais e econômicas para o paciente e sua família. Diante desse panorama, é crescente a necessidade de profissionais qualificados para desenvolverem a assistência aos pacientes com câncer, dentre os quais se encontra o enfermeiro. Assim, este estudo teve como objetivo conhecer o que tem sido produzido por enfermeiros brasileiros sobre enfermagem e oncologia. Trata-se de uma revisão narrativa da literatura. O levantamento bibliográfico foi realizado em dezembro de 2016 na base de dados Medical Literature Analysis and Retrieval System Online ­ MEDLINE, por meio da estratégia de busca "Enfermagem" AND "Oncologia". Inicialmente, foram encontrados 2.245 estudos, dos quais 14 compuseram o corpus da revisão. Os estudos sobre enfermagem e oncologia versavam sobre o manuseio da dor, terapias complementares, saúde do homem, cuidados paliativos e assistência domiciliar e oncologia pediátrica. Sendo o envelhecimento um fator para o desenvolvimento do câncer, nenhum artigo falou sobre o câncer no paciente idoso o que demonstra uma lacuna quanto à abordagem da temática com essa população.


Cancer has numerous epidemiological, social and economic implications for both the patient and his family. Given this scenario, there is a growing need for qualified professionals to provide care for cancer patients, nurses included. Thus, this study aimed at understanding the production of Brazilian nurses regarding nursing and oncology. This is a narrative literature review, with a bibliographic survey performed in December 2016 in the Medical Literature Analysis and Retrieval System Online database ­ MEDLINE using the search criteria "Nursing" AND "Oncology". Initially, a total of 2.245 studies were found, from which 14 were included in the corpus of the review. Nursing and oncology studies addressed pain management, complementary therapies, human health, palliative and home care, as well as pediatric oncology. Since aging is a relevant factor for the development of cancer, no article addressed the topic of cancer in the elderly, which shows a gap regarding the thematic approach concerning that population.


Subject(s)
Nurse's Role , Medical Oncology/education , Neoplasms/nursing , Nursing Care , Palliative Care , Complementary Therapies/nursing , MEDLINE , Men's Health , Pain Management/nursing , Home Care Services , Nurse-Patient Relations , Nurses
20.
Arq. ciências saúde UNIPAR ; 23(1): 57-64, jan-abr. 2019.
Article in Portuguese | LILACS | ID: biblio-979976

ABSTRACT

A presente pesquisa é de natureza bibliográfica, compreendida como uma revisão sistemática da literatura. Tem como questão principal: "Qual é o estado da arte no que tange a temática do plágio na produção científica da área da saúde no Brasil?". Considera que o plágio, apesar de se agravar na era da informação, existe há muito tempo e que este, quando se prolifera no fazer científico, nas publicações e passa despercebido por avaliadores, acarreta prejuízos financeiros, ético-morais e desprestígio da ciência. Uma forma de verificar como estão avançando as discussões e observar a apropriação desse tema pela comunidade científica brasileira dá-se mediante a apreciação de artigos sobre plágio publicados nos periódicos indexados em bases de dados. Este trabalho objetivou delinear o cenário da produção científica acerca do plágio na área da saúde a partir de artigos indexados em periódicos científicos brasileiros entre os anos de 2010 a 2015. A revisão sistemática da literatura foi realizada nos bancos de dados eletrônicos LILACS, MEDLINE e ColecionaSUS, utilizando-se palavra-chave para capturar os artigos. Após aplicação dos critérios de inclusão e exclusão, foram selecionadas 14 publicações. Verificou-se que a discussão sobre o plágio é ainda incipiente no Brasil. O plágio é visto como um assunto complexo que necessita de enfrentamento, com ações educativas desde a formação inicial, com corresponsabilização da sociedade e pesquisadores. Verificou-se que ainda há lacunas na produção científica brasileira.


This is a bibliographic research, understood as a systematic literature review. It attempts to answer the main question: "What is the state of the art regarding the topic of plagiarism in the scientific production in the health area in Brazil?". It considers that plagiarism, although worsened in the information age, has existed for a long time. And when it proliferates in the scientific work and publications, going unnoticed by evaluators, results in financial losses, damaging both ethical and moral prestige of the sciences. One way to check the advancement in the discussions and observe the appropriation of this issue by the Brazilian scientific community is through the appreciation of articles regarding plagiarism published in database-indexed journals. This study aimed to outline the scientific production scenario regarding plagiarism in health from articles indexed in Brazilian scientific journals between 2010 and 2015. A systematic literature review was conducted in the electronic databases LILACS, MEDLINE and ColecionaSUS using keyword to capture the articles. After the application of inclusion and exclusion criteria, a total of 14 publications were selected. It could be observed that the discussion regarding plagiarism is still incipient in Brazil. Plagiarism is seen as a complex issue that requires actions to be taken, including educational activities from the initial training, with co-responsibility of the society and researchers. It was also observed that gaps still exist in the Brazilian scientific production.


Subject(s)
Catchment Area, Health/statistics & numerical data , Plagiarism , Scientific and Technical Activities , Scientific and Technical Publications , MEDLINE/statistics & numerical data , Copyright/ethics , Scientific Publication Ethics , LILACS/statistics & numerical data
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