Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 20
Filter
Add filters








Year range
1.
Article in Chinese | WPRIM | ID: wpr-880441

ABSTRACT

Coagulometer, known as blood coagulation analyzer, is a product that can provide accurate test results for medical diagnosis and treatment analysis by detecting a series of items closely related to thrombosis and hemostasis in coagulation reaction. On the basis of previous traditional methods, and with our deep understanding about the principles of hemagglutination detection, we propose a hemagglutination detection method by using the dual-magnetic circuit beads method. Then, the corresponding hemagglutination detection module is designed. The coagulation time of plasma can be measured by detecting the movement of the magnetic beads when the magnetic field intensity is appropriate. The activated partial thromboplastin time(APTT) of plasma is tested when the most suitable magnetic field intensity is found. The results preliminarily show that this blood coagulation test method is valid and the corresponding test module has a potential value in business.


Subject(s)
Blood Coagulation , Blood Coagulation Tests , Magnetic Phenomena , Magnetics , Partial Thromboplastin Time
2.
Article in Chinese | WPRIM | ID: wpr-880418

ABSTRACT

The magnetic anchoring lung nodule positioning device is composed of a target magnet, an anchor magnet, a coaxial puncture needle and a puncture navigation template, through these, a new type of accurate positioning technology for small pulmonary nodules is derived. The device inserts the target magnet into the both sides nearby the lung nodule under the guidance of CT. Helped by the mutual attraction of the two target magnets, they can be fixed in the lung tissue, avoiding the movement in the lung, and accurately positioning the target lung nodule before surgery. In thoracoscopic surgery, the anchor magnet and the target magnet attract each other to achieve the purpose of positioning the target nodule. The device uses the characteristics of non-contact suction of magnetic materials biomedical engineering technology, eliminating the previous procedure of direct interaction with the positioning marks, finally achieves the target of precise positioning of lung nodules and rapid surgical removal.


Subject(s)
Humans , Lung , Lung Neoplasms , Magnetic Phenomena , Magnets , Solitary Pulmonary Nodule , Thoracic Surgery, Video-Assisted , Tomography, X-Ray Computed
3.
Article in Chinese | WPRIM | ID: wpr-880416

ABSTRACT

OBJECTIVE@#In the context of coronavirus disease 2019 (COVID-19) pandemic, the subject was designed to develop a new tracheal intubation device based on magnetic navigation technology to improve the success rate of tracheal intubation and reduce the risk of occupational exposure of medical staff.@*METHODS@#The new tracheal intubation device was designed with the uniqueness of the magnetic field environment and magnetic steering of magnetic navigation technology. And preliminary magnetic navigation tracheal intubation experiments were performed on the tracheal intubation simulator.@*RESULTS@#Magnetic navigation tracheal intubation can successfully implement tracheal intubation, and the time required is lower than that of traditional laryngoscopy.@*CONCLUSIONS@#The tracheal intubation based on magnetic navigation technology is feasible, with high efficiency and easy operation. That is expected to be widely used for tracheal intubation during treatment of patients outside the hospital in the future. At the same time, magnetic navigation endotracheal intubation technology will be the key technology for the development of endotracheal intubation robots.


Subject(s)
COVID-19/therapy , Equipment Design , Feasibility Studies , Humans , Intubation, Intratracheal , Magnetic Phenomena , SARS-CoV-2 , Technology
4.
Article in Chinese | WPRIM | ID: wpr-879269

ABSTRACT

As a noninvasive neuromodulation technique, transcranial magnetic stimulation (TMS) is widely used in the clinical treatment of neurological and psychiatric diseases, but the mechanism of its action is still unclear. The purpose of this paper is to investigate the effects of different frequencies of magnetic stimulation (MS) on neuronal excitability and voltage-gated potassium channels in the


Subject(s)
Action Potentials , Animals , Magnetic Phenomena , Mental Disorders , Mice , Neurons , Patch-Clamp Techniques , Potassium Channels, Voltage-Gated
5.
Chinese Acupuncture & Moxibustion ; (12): 1159-1163, 2020.
Article in Chinese | WPRIM | ID: wpr-877579

ABSTRACT

OBJECTIVE@#To observe effect of magnetic beads auricular point sticking therapy on intrapartum fever in primipara with epidural labor analgesia and explore its possible mechanism.@*METHODS@#A total of 160 primipara were randomly divided into an observation group (80 cases, 12 cases dropped off ) and a control group (80 cases, 15 cases dropped off ). The primipara in the control group received epidural labor analgesia. In the observation group, 15 min after epidural labor analgesia was performed, magnetic beads auricular point sticking therapy was given at shenmen (TF@*RESULTS@#There was no significant difference in tympanic temperature in the observation group at each time point (@*CONCLUSION@#Magnetic beads auricular point sticking therapy can reduce the amount of anesthetics, decrease the effect of epidural analgesia on primipara's body temperature regulation and labor progress, and lower the incidence of fever during labor analgesia by regulating the level of inflammatory response in the primipara.


Subject(s)
Analgesia, Epidural , Analgesia, Obstetrical , Analgesics , Cesarean Section , Female , Humans , Labor, Obstetric , Magnetic Phenomena , Pregnancy
6.
Article in Chinese | WPRIM | ID: wpr-781252

ABSTRACT

OBJECTIVE@#To construct a magnetic and catalytic hairpin assembly-based platform for detection of dual membrane proteins on exosomes.@*METHODS@#Exosomes in supernatant of breast cancer MDA-MB-231 cell culture were separated, purified and characterized. Super-resolution imaging and Western blotting were performed to confirm the expression of the membrane protein CD63 on the exosomes. Polyacrylamide gel electrophoresis was used to verify the combination of Apt-T and exosomes. Fluorescence experiments were carried out to test the feasibility of CHA nucleic acid sequence, optimize the reaction conditions, and determine the specificity of the detection platform.@*RESULTS@#Super-resolution imaging and Western blotting showed that breast cancer MDA-MB-231 cell-derived exosomes expressed abundant membrane protein CD63. Polyacrylamide gel electrophoresis indicated that Apt-T could recognize and bind to exosomes. The results of specificity test showed that the signal-to-noise ratio of the detection platform was 1.10±0.01 for detecting normal human breast epithelial cell-derived exosomes, and was 2.09±0.08 for breast cancer cell-derived exosomes.@*CONCLUSIONS@#Magnetic and catalytic hairpin assembly-based detection platform allows simultaneous detection of two membrane proteins expressed on exosomes and identification of the expressions of membrane proteins on exosomes from different sources.


Subject(s)
Blotting, Western , Exosomes , Humans , Magnetic Phenomena , Membrane Proteins , Sensitivity and Specificity
7.
Article in Chinese | WPRIM | ID: wpr-310288

ABSTRACT

<p><b>OBJECTIVE</b>In order to accurately reconstruct the acoustic source image, the application of transducer's receiving characteristics in magneto-acoustic tomography with magnetic induction (MAT-MI) is studied.</p><p><b>METHODS</b>The conductivity phantom model is built, and the magnetic acoustic signals are simulated and the acoustic sources are reconstructed according to the transducer's receiving characteristics.</p><p><b>RESULTS</b>The reconstructed image of acoustic source is consistent with the topographic shape and size of the phantom model.</p><p><b>CONCLUSION</b>MAT-MI based on the transducer's characteristics lays the foundation for further study.</p>


Subject(s)
Acoustics , Magnetic Phenomena , Magnetics , Tomography , Transducers
8.
Article in Chinese | WPRIM | ID: wpr-329180

ABSTRACT

<p><b>OBJECTIVE</b>To establish a method for detecting 3 common toxigenic molds (Aspergillus, Penicillium, and Fusarium) based on non-modified magnetic beads coupled with multiple real-time PCR (NMB-multiple qPCR).</p><p><b>METHODS</b>The primers and genus-specific probes were designed based on the rDNA sequences to develop a multiple real-time PCR using non-modified magnetic bead to enrichment of fungal spores. The sensitivity, specificity and repeatability of this assay were evaluated.</p><p><b>RESULTS</b>The detection limit of this assay for spiked samples was 10(4) CFU/g, demonstrating a 10-fold greater detection sensitivity of this assay than that of real-time PCR. The NMB-multiple qPCR assay also showed good specificity and reproducibility and yielded comparable results with those by traditional colony counting method for spiked samples (P>0.05).</p><p><b>CONCLUSION</b>NMB-multiple qPCR assay we established allows rapid and sensitive detection of common mycotoxigenic fungi in paprika.</p>


Subject(s)
Aspergillus , Capsicum , Microbiology , DNA Primers , Food Contamination , Food Microbiology , Fungi , Fusarium , Magnetic Phenomena , Penicillium , Real-Time Polymerase Chain Reaction , Methods , Reproducibility of Results , Sensitivity and Specificity
9.
Article in Chinese | WPRIM | ID: wpr-359605

ABSTRACT

This study was aimed to improve the sensitivity of magnetic induction phase shift detection system for cerebral hemorrhage. In the study, a cerebral hemorrhage model with 13 rabbits was established by injection of autologous blood and the cerebral hemorrhage was detected by utilizing magnetic induction phase shift spectroscopy (MIPSS) detection method under the feature band. Sixty five groups of phase shift spectroscopy data were obtained. According to the characteristics of cerebral hemorrhage phase shift spectroscopy under the feature hand, an effective method, B-F distribution, to diagnose the severity of cerebral hemorrhage was designed. The results showed that using MIPSS detection method under feature band, the phase shift obviously growed with increase of injection volume of autologous blood, and the phase shift induced by a 3-mL injection reached -7.750 3 degrees ± 1.420 4 degrees. B-F distribution could effectively diagnose the severity of cerebral hemorrhage. It can be concluded that the sensitivity of the cerebral hemorrhage magnetic induction detection system is improved by one order of magnitude with the MIPSS detection method under the feature band.


Subject(s)
Animals , Cerebral Hemorrhage , Diagnosis , Magnetic Phenomena , Magnetics , Rabbits , Spectrum Analysis , Methods
10.
Article in Chinese | WPRIM | ID: wpr-259672

ABSTRACT

Magnetic induction hyperthermia becomes a very important tumor treatment method at present. In order to ensure a successful operation, doctors should make hyperthermia treatment planning before surgery. Based on Integration Healthcare Enterprise (IHE) framework and Digital Imaging and Communications in Medcine (DICOM) standard, we proposed and carried out a network workflow integrated with modern medical information systems for the dissemination of information in magnetic induction hyperthermia like accurate accessing patient information and radiology image data, storing processed images, sharing and verifying hyperthermia reports. The results proved that our system could not only improve the efficiency of magnetic induction hyperthermia treatment planning, but also save medical resources and reduce labor costs.


Subject(s)
Humans , Hyperthermia, Induced , Image Processing, Computer-Assisted , Magnetic Phenomena , Neoplasms , Therapeutics , Radiology Information Systems , Systems Integration
11.
Journal of Biomedical Engineering ; (6): 1050-1056, 2014.
Article in Chinese | WPRIM | ID: wpr-234460

ABSTRACT

The purpose of this paper is to report the research and design of control system of magnetic coupling centrifugal blood pump in our laboratory, and to briefly describe the structure of the magnetic coupling centrifugal blood pump and principles of the body circulation model. The performance of blood pump is not only related to materials and structure, but also depends on the control algorithm. We studied the algorithm about motor current double-loop control for brushless DC motor. In order to make the algorithm adjust parameter change in different situations, we used the self-tuning fuzzy PI control algorithm and gave the details about how to design fuzzy rules. We mainly used Matlab Simulink to simulate the motor control system to test the performance of algorithm, and briefly introduced how to implement these algorithms in hardware system. Finally, by building the platform and conducting experiments, we proved that self-tuning fuzzy PI control algorithm could greatly improve both dynamic and static performance of blood pump and make the motor speed and the blood pump flow stable and adjustable.


Subject(s)
Algorithms , Assisted Circulation , Fuzzy Logic , Heart-Assist Devices , Magnetic Phenomena , Magnetics
12.
Article in Chinese | WPRIM | ID: wpr-315898

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the root length of posterior teeth after palatal expansion by magnetic expansion appliance.</p><p><b>METHODS</b>A total of 32 patients who accepted palatal expansion with magnetic expansion appliance were enrolled in the study. Pretreatment and post-treatment cone-beam computed tomography (CBCT) images were obtained. A paired t test was used to evaluate the length change, and a group t test was used to compare the tooth lengths of developing and developed teeth.</p><p><b>RESULTS</b>Anchorage teeth showed greater root resorption than non-anchorage teeth, whereas the developed posterior teeth showed reduced resorption. Moreover, the mesial buccal roots of the first molar and first premolar were reduced. No resorption was found in the developing teeth group.</p><p><b>CONCLUSION</b>The magnetic palatal expansion can reduce the root length, particularly of developed root. The developing root of anchorage teeth show greater tolerance to resorption than the developed root. Early palatal expansion treatment with magnetic expansion appliance can reduce the risk of root resorption.</p>


Subject(s)
Bicuspid , Cone-Beam Computed Tomography , Humans , Magnetic Phenomena , Molar , Palatal Expansion Technique , Root Resorption
13.
Article in Chinese | WPRIM | ID: wpr-352148

ABSTRACT

This article summarizes biological detection techniques based on magnetic signal of magnetic nanoparticles and the research progress of these techniques in biomedicine. Biological detection based on magnetic nanoparticles is faster, more accurate and more convenient compared to traditional optical techniques and causes much attention. It can be classified into giant magneto resistive biosensor (GMR), magnetic relaxation switch (based on T2 relaxation time), AC susceptibility (based on Brownian relaxation) and magnetic lateral flow immunoassay. These techniques can be combined with nanotechnology, microfluidics, immunoassay and bio-chips and have wide application prospects in clinical diagnosis, biological detection, environmental monitoring and food security areas.


Subject(s)
Biosensing Techniques , Methods , Immunoassay , Methods , Magnetic Phenomena , Nanoparticles , Chemistry , Nanotechnology , Point-of-Care Systems
14.
Article in Chinese | WPRIM | ID: wpr-342951

ABSTRACT

Magnetic Particle Imaging (MPI) is a new medical imaging tool, which was born at the beginning of the 21st century. Compared with traditional imaging techniques, the preliminary research indicates that MPI shows higher sensitivity, resolution and imaging speed. This article presents the principle of MPI, its recent development from three different perspectives is introduced.


Subject(s)
Diagnostic Imaging , Magnetic Phenomena , Magnetic Resonance Imaging , Methods , Molecular Imaging
15.
Article in Chinese | WPRIM | ID: wpr-241913

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the influence of class III forces in craniofacial morphology and sutural histology in Rhesus monkeys.</p><p><b>METHODS</b>Six male Rhesus monkeys in mixed dentition were employed in this study, two as 90-day experimental group, two as 45-day experimental group and the other two as control respectively. The experimental monkeys were casted magnetic orthopedic appliance-III (MOA-III), the control monkeys received no treatment. Intraoral photographs, casts and cephalometric radiographs of each animal were obtained at the beginning and at the end of the experiment. Fluorescent and haematoxylin-eosin staining were used to observe the histological changes in craniofacial sutures. RESULTS; In experimental groups, the maxillomandibular relationship changed more significantly in 90-day experimental group than 45-day experimental animals. But changes were scarcely noted in the control. The bony depositions of the sutures were distinctly found during the experimental period, especially in zygomaticomaxillary, transverse palatine, pterygopalatine and zygomaticotemporal sutures.</p><p><b>CONCLUSION</b>This study indicates that this kind of magnetic appliance could cause skeletal and dental changes of maxilla and mandible, and change the arrangement of connective tissues in craniofacial sutures, and lead to significant new bone deposition in craniofacial sutures.</p>


Subject(s)
Animals , Cephalometry , Macaca mulatta , Magnetic Phenomena , Male , Mandible , Maxilla , Skull
16.
Article in Chinese | WPRIM | ID: wpr-242967

ABSTRACT

<p><b>OBJECTIVE</b>To explore the clinical effect of combined application of magnetic attachments and extracoronal attachments in prosthodontics.</p><p><b>METHODS</b>Twenty-two cases of dentition defect with isolated residual root or residual crown were selected. All the cases accepted the restorative treatment combined magnetic attachments with extracoronal attachments. The clinical effect of dentures and the condition of abutment teeth were evaluated by chief complaint of patients and clinical examination. The follow-up time ranged from 2 years to 4 years.</p><p><b>RESULTS</b>Satisfactory functional, stable and esthetic results of dentures were achieved for all the cases. And there was no abutment loosening and no secondary caries. Alveolar bone loss around abutment occurred in 1 case, gingivitis of abutments appeared in 5 cases. Chewing pain occurred in 1 case and unstable state of dentures appeared in 5 cases after the use of denture for 2 years. The dentures of above-mentioned cases were used normally after symptomatic treatment.</p><p><b>CONCLUSION</b>The combined application of magnetic attachments and extracoronal attachments in prosthodontics is an effective treatment option for cases of dentition defect with isolated residual root or residual crown.</p>


Subject(s)
Crowns , Dental Abutments , Dental Caries , Denture Design , Denture Retention , Denture, Partial, Removable , Humans , Magnetic Phenomena
17.
Article in Chinese | WPRIM | ID: wpr-348060

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the biologic effects of simulating static magnetic field of magnetic attachment on human periodontal ligament fibroblasts (HPDLF).</p><p><b>METHODS</b>HPDLF were cultured in vitro and exposed to simulating static magnetic fields of magnetic attachments for 4 days with magnetic flux density of 12.5, 125 and 250 mT respectively, while the control group free of additional static magnetic field was also set up. The activities of cellular alkaline phosphatase (ALP) and superoxide dismutase (SOD) were measured with a spectrophotometer, and cell cycle was analyzed by flow cytometry.</p><p><b>RESULTS</b>An increase were detected, induced by 250 mT static magnetic field exposure for 4 days in terms of activity of ALP in HPDLF, as compared with the control group (P < 0.05). However, no corresponding effects were found in activity measurements of SOD (P > 0.05). Also there were no statistical differences observed on cell cycle distribution (P > 0.05) or cell proliferation index (P > 0.05) under such static magnetic fields.</p><p><b>CONCLUSION</b>The static magnetic fields of magnetic attachment used in this study have improved the activity of ALP, and do little inference to the activity of SOD and the cell cycle distribution.</p>


Subject(s)
Alkaline Phosphatase , Biological Products , Cell Proliferation , Fibroblasts , Humans , Magnetic Fields , Magnetic Phenomena , Magnetics , Periodontal Ligament
18.
Article in Chinese | WPRIM | ID: wpr-348026

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of the static magnetic field (SMF) generated by dental magnetic attachments on osteoblastic proliferations, cell cycle distribution, and apoptosis ratio.</p><p><b>METHODS</b>By simulating those of the closed-field, the closure process and the open-field Magnedisc 800 magnetic attachments respectively, the in vitro cultured rat osteoblasts were exposed continuously to 12.5, 125, 250 mT SMF. The effects of the SMF on the proliferation of the cells were examined. MTT colorimetry test was performed to detect the effect of the SMF on the vitalities of cells. Flow cytometry was utilized to analyze the cell cycles and cell apoptosis rates.</p><p><b>RESULTS</b>The SMF exposure didn't change the vital osteoblasts number, the cell cycle distribution and proliferation activities of osteoblasts. The cell apoptosis situation were not observed statistical differences.</p><p><b>CONCLUSION</b>No matter the closed-field, the closure process and the open-field magnetic attachments respectively, continuous simulating SMF-stimulation of magnetic attachments couldn't change osteoblasts proliferation activity, cell cycle distribution, and apoptosis ratio.</p>


Subject(s)
Animals , Apoptosis , Cell Cycle , Cell Proliferation , Electromagnetic Fields , Magnetic Fields , Magnetic Phenomena , Magnetics , Osteoblasts , Rats
19.
Article in Chinese | WPRIM | ID: wpr-288940

ABSTRACT

<p><b>OBJECTIVE</b>This study was intended to design a kind of resisting part dint of device in order to preventing the base plate break while being subjected to the dint when partial base plate dint concentrates because of the increase of the magnetic attachment to the original movable artificial teeth.</p><p><b>METHODS</b>Ten patients who should increase magnetic attachment was adopted in the study, and we increased a kind of new designed partial cast base plate on the original base plate using laser welding technique, then designed magnetic attachment and artificial teeth.</p><p><b>RESULTS</b>None of ten sufferers appeared the phenomenon of the break of the base plate.</p><p><b>CONCLUSION</b>The application of the laser welding technique can prevent the break of the base plate when partial dint increase because of the increase of the magnetic attachments.</p>


Subject(s)
Dental Soldering , Humans , Lasers , Magnetic Phenomena , Magnetics , Welding
20.
Article in Chinese | WPRIM | ID: wpr-300255

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate treatment outcomes of mandibular complete denture supported by two endosteal magnetic-attachment implants in edentulous patients with severe mandibular alveolar ridge absorption.</p><p><b>METHODS</b>Eight edentulous patients with severe mandibular alveolar ridge absorption were chosen. Each of them was treated with a complete denture supported by two CDIC implants. The implants were inserted at the areas of two the first premolars respectively. After five months, two magnets were adhered to the inside of the complete dentures. Retention, masticatory efficiency and maximal masticatory force were measured before and after the magnets were adhered and six months later.</p><p><b>RESULTS</b>Statistical analysis revealed that retention, masticatory efficiency and maximal masticatory force were all increased after the magnets were adhered (P < 0.01) and six months later (P < 0.01).</p><p><b>CONCLUSION</b>Retention, maximal masticatory force and masticatory efficiency were significantly increased after the endosteal magnetic attachment implants were applied. It is concluded that mandibular complete denture supported by two endosteal magnetic attachment implants is an effective method for severe alveolar ridge absorption cases.</p>


Subject(s)
Alveolar Process , Dental Prosthesis, Implant-Supported , Denture, Complete , Denture, Overlay , Female , Humans , Magnetic Phenomena , Male , Mandible , Mastication , Middle Aged , Mouth, Edentulous , Patient Satisfaction
SELECTION OF CITATIONS
SEARCH DETAIL