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1.
Arch. argent. pediatr ; 119(1): 44-50, feb. 2021. tab, ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1147085

ABSTRACT

Objetivo. Determinar la adherencia de pacientes oncológicos pediátricos a la medicación oral del mantenimiento y conocer sus creencias sobre la medicación.Población y métodos. Durante 2018-19, se recogió información de padres, adolescentes y oncólogos en seis hospitales públicos pediátricos de la Argentina. Se administraron cuestionarios de adherencia (Simplified Medication Adherence Questionnaire) y de creencias sobre la medicación (Beliefs About Medicines Questionnaire). Se consideró adherente a quien refirió tomar la medicación sin saltear dosis y respetando el tiempo de ayuno.Resultados. N = 203 pacientes. La adherencia informada por los padres fue del 75 %; la estimada por los oncólogos, del 82 %, y la referida por adolescentes, del 45 %. Las variables que mostraron asociación con la adherencia fueron solvencia económica, diagnóstico, hospital tratante, cantidad de hijos a cargo, tratamientos oncológicos realizados y existencia de obstáculos en el cumplimiento. Esta muestra no percibía los medicamentos como dañinos, pero consideró que se los utilizaba abusivamente. La mayoría percibía la necesidad de tomar la medicación antineoplásica para mantener/recuperar la salud, pero también expresó preocupaciones. La percepción sobre la medicación fue similar entre los padres y los adolescentes, y no se asoció con el nivel de adherencia.Conclusiones. La adherencia informada por los padres en esta muestra fue del 75 %. Los padres y los pacientes percibían la medicación como necesaria y manifestaron preocupaciones vinculadas al tratamiento


Objective. To determine the adherence to oral maintenance medication among pediatric cancer patients and know their beliefs about medications.Population and methods. Information was obtained from parents, adolescents, and oncologists from six public children's hospitals of Argentina during 2018 and 2019. Questionnaires on adherence (Simplified Medication Adherence Questionnaire) and beliefs about medication (Beliefs About Medicines Questionnaire) were administered. Patients were considered adherent if they referred taking their medication without missing a dose and complying with fasting time.Results. N = 203 patients. Parent-reported adherence was 75 %; adherence estimated by oncologists, 82 %; and that referred by adolescents, 45 %. The outcome measures associated with adherence were financial solvency, diagnosis, treating hospital, number of children under the care of the caregiver, cancer treatments received, and presence of barriers in compliance. Sample subjects did not perceive medications as harmful, but considered they were overused. Most subjects perceived the necessity to take antineoplastic agents to maintain or recover their health, but also expressed their concerns. The perception about medication was similar between parents and adolescents, and was not associated with the level of adherence.Conclusions. In this sample, parent-reported adherence was 75 %. Parents and patients perceived a necessity for medication and expressed their concerns about treatment.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Medication Adherence , Treatment Adherence and Compliance , Antineoplastic Agents , Leukemia , Surveys and Questionnaires , Maintenance
2.
San Salvador; MINSAL; ene. 11, 2021. 17 p. graf.
Non-conventional in Spanish | LILACS, BISSAL | ID: biblio-1147073

ABSTRACT

La conservación y el mantenimiento de los bienes institucionales relacionados a infraestructura, instalaciones, equipo, mobiliario y otros, forma parte de las áreas más importantes en apoyo a los procesos institucionales claves, ya que de su funcionamiento óptimo depende en mucho la producción de servicios de salud y la calidad de esa producción


The conservation and maintenance of institutional assets related to infrastructure, facilities, equipment, furniture and others, is part of the most important areas in support of key institutional processes, since the production of services depends largely on their optimal functioning. health and the quality of that production


Subject(s)
Health Infrastructure , Maintenance , Manuals as Topic
3.
Article in English | LILACS, INDEXPSI | ID: biblio-1346625

ABSTRACT

Abstract Research on retirement have traditionally been centered on the individual perspective of the phenomenon. This qualitative study aimed at understanding the relational dynamics in meaningful social networks during the retirement process, as perceived by members of retirees' networks. Nine people indicated by retirees as members of their social networks (spouses, siblings, friends, and former coworkers) participated in this study. Data collection was performed through the Focus Group technique, and field notes were recorded. Data organization and analysis were based on the Grounded Theory and aided by the Atlas.ti software - Mac version 1.6.0. Results show that retirement triggers a recursive process to break, maintain, or redevelop bonds, with repercussions on the relational issues and proposals among the network of retirees. The study data suggest that the relational dimension greatly affects the retirees' experience as well as their relational network.


Resumo As pesquisas sobre aposentadoria, tradicionalmente, centraram-se na ótica individual desse fenômeno. Este estudo qualitativo teve por objetivo compreender a dinâmica relacional das redes sociais significativas no processo de aposentadoria, na perspectiva de membros das redes de aposentados. Participaram 09 pessoas indicadas por aposentados como membros de suas redes (cônjuges, irmão, amigos e ex-colegas de trabalho). Para a coleta de dados utilizou-se a técnica de Grupo Focal e foram efetivados registros em diário de campo. A organização e a análise dos dados fundamentou-se na Grounded Theory e contou com o auxílio do software Atlas.ti versão 1.6.0 para Mac. Os resultados evidenciaram que a aposentadoria desencadeia um processo recursivo de ruptura, manutenção e/ou reconstrução de vínculos, produzindo repercussões nas propostas relacionais entre os membros da rede dos aposentados. Os dados deste estudo sugerem que a dimensão relacional afeta decididamente as experiências tanto do aposentado quanto da rede configurada em torno dele.


Resumen La investigación sobre la jubilación se ha centrado tradicionalmente en la perspectiva individual del fenómeno. Este estudio cualitativo tuvo como objetivo comprender la dinámica relacional de las redes sociales en el proceso de jubilación, desde la perspectiva de los miembros de las redes de jubilados. Participaron 09 personas nombradas por jubilados como miembros de sus redes. Los datos fueron recolectados usando la técnica de grupo focal y registro de diario de campo. La organización y el análisis de los datos se basaron en la teoría fundamentada y fueron respaldados por el software Atlas.ti versión 1.6.0 para Mac. Los resultados mostraron que la jubilación desencadena un proceso recursivo de ruptura, mantenimiento y/o reconstrucción de enlaces, produciendo repercusiones en la propuesta relacional entre los integrantes de la red. Los datos de este estudio sugieren que la dimensión relacional incide decisivamente en las vivencias tanto del jubilado como de su red social.


Subject(s)
Humans , Retirement , Work , Focus Groups , Social Networking , Social Interaction , Maintenance
4.
Rev. Fundac. Juan Jose Carraro ; 24(44): 54-63, 2021.
Article in Spanish | LILACS | ID: biblio-1223712

ABSTRACT

La periodontitis es una enfermedad inflamatoria, crónica que afecta a los tejidos de soporte de los dientes y puede repercutir en la salud general, afectando la calidad de vida del paciente. La enfermedad de Alzheimer es una condición neurodegenerativa y progresiva que va disminuyendo la memoria, el lenguaje y aprendizaje de los pacientes. El objetivo de la investigación es realizar una revisión bibliográfica para comprender la posible vinculación entre la periodontitis y el Alzheimer. Los microorganismos periodontopatógenos producen una respuesta inflamatoria que, por vía sistémica, puede desencadenar un mecanismo inflamatorio dentro del sistema nervioso central. La respuesta del hospedero es liberar gran cantidad de moléculas proinflamatorias que comprometen la barrera hematoencefálica sobreestimulando a las células microgliales, esto conduce a la destrucción de neuronas vitales y al mantenimiento de la inflamación crónica que contribuye a la progresión del Alzheimer. Por otra parte, la periodontitis puede favorecer la formación de placas ateromatosas que afectan la integridad vascular siendo éste un factor a considerar en el desarrollo de la patología cerebrovascular. A pesar que son pocos los estudios clínicos experimentales, ya se puede sugerir la correlación entre ambas enfermedades (AU)


Periodontitis is a chronic inflammatory disease that affects the supporting tissues of teeth, affecting the systemic health and quality of life of the patient. Alzheimer's disease is a neurodegenerative and progressive condition that decreases memory, speech and learning of patients. The objective of this literature review was to report the possible link between periodontitis and Alzheimer's disease. Periodontopathogens produce an inflammatory response that, systemically, can trigger an inflammatory mechanism within the central nervous system. Due to this attack, the host releases a great quantity of proinflammatory molecules that compromise the blood-brain barrier by over- stimulation microglial cells, this produces destruction of vital neurons and maintenance the chronic inflammation in CNS and that contribute to the progression of Alzheimer's disease. On the other hand, periodontitis can favor the formation of atheromatous plaques that affect vascular integrity, being a factor to consider in the development of the cerebrovascular disease. Although there are few experimental clinical studies, the correlation between both diseases can already be suggested (AU)


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Periodontitis/complications , Periodontitis/prevention & control , Alzheimer Disease/etiology , Cerebrovascular Disorders , Chronic Disease , Inflammation Mediators/physiology , Dental Plaque/prevention & control , Maintenance
5.
Article in Chinese | WPRIM | ID: wpr-879805

ABSTRACT

OBJECTIVE@#To study the clinical effect of an additional maintenance dose (5 mg/kg) of caffeine citrate injection at 1 hour before ventilator weaning in improving the success rate of ventilator weaning in preterm infants (gestational age ≤32 weeks) with respiratory distress syndrome (RDS) on mechanical ventilation.@*METHODS@#A total of 338 preterm infants with RDS (gestational age of ≤32 weeks) who were admitted to the Neonatal Intensive Care Unit of Xiamen Maternal and Child Health Hospital from January 2017 to December 2019 and treated with mechanical ventilation were enrolled. They were randomly divided into an observation group and a routine group, with 169 infants in each group. Both groups received early routine treatment with caffeine. The infants in the observation group received an additional maintenance dose of caffeine citrate injection at 1 hour before ventilator weaning. The two groups were compared in terms of reintubation rate and number of apnea episodes within 48 hours after ventilator weaning, changes in blood gas parameters, blood glucose, heart rate, and mean blood pressure at 2 hours after ventilator weaning, and incidence rates of major complications during hospitalization.@*RESULTS@#Compared with the routine group, the observation group had significantly lower reintubation rate (@*CONCLUSIONS@#An additional maintenance dose of caffeine citrate injection at 1 hour before ventilator weaning is safe and effective in improving the success rate of ventilator weaning in preterm infants with RDS and thus holds promise for clinical application.


Subject(s)
Caffeine , Humans , Infant , Infant, Newborn , Infant, Premature , Maintenance , Prospective Studies , Respiratory Distress Syndrome, Newborn/therapy , Ventilator Weaning
6.
Chinese Journal of Stomatology ; (12): 127-135, 2021.
Article in Chinese | WPRIM | ID: wpr-879313

ABSTRACT

Periodontal disease is the main cause of tooth loss in adults, and it is also one of the major factors affecting oral and general health. In the process of diagnosing and treating the oral diseases, many subspecialties of stomatology will involve in the maintenance of periodontal tissue health. The Chinese Stomatological Association organized a number of experts in related disciplines to thrash out the present expert consensus in order to enhance the awareness of dental clinicians to maintain the health of periodontal tissues and to standardize the procedures of diagnosis and treatment. The clinicians' abilities in prevention and treatment of oral diseases will be hopefully elevated if the clinicians, especially in such disciplines as prosthodontics, orthodontics, oral implantology, operative dentistry and endodontics, can early recognize and identify the periodontal disease and the damage degree of periodontal tissues, adopt the appropriate intervention measures and predict the prognosis scientifically.


Subject(s)
Adult , China , Consensus , Humans , Maintenance , Oral Medicine , Periodontal Diseases/prevention & control
7.
São Paulo; s.n; s.n; 2020. 133 p. tab, graf.
Thesis in Portuguese | LILACS | ID: biblio-1292693

ABSTRACT

A regulação da fosforilação/desfosforilação das proteínas é o eixo central de muitas cascatas de sinalização. A fosfatase DUSP3, constituída apenas por um único domínio catalítico, desempenha papéis fundamentais na proliferação e senescência celular. Nas células HeLa, submetidas ao estresse genotóxico, o DUSP3 interage fisicamente com as proteínas HNRNPC, mas o efeito dessa função molecular ainda é desconhecido. Aqui demostramos que a ausência de DUPS3 mantem a proteína HNRNPC1/C2 num estado hiperfosforilado. Para entender melhor o envolvimento da interação DUSP3-HNRNPC nas funções biológicas da HNRNPC1/C2, foram estudadas células de fibroblasto deficientes de DUSP3. Foi analisado o efeito da deficiência de DUSP3 na biogênese dos ribossomos através do ensaio de perfil de polirribossomos e quantificação dos rRNAs com RT-qPCR. Os resultados mostraram que a deficiência de DUSP3 não afeta a maturação das subunidades ribossômicas, mas teria um impacto na transcrição dos pré-rRNAs e no acumulo das espécies 47S/45S. A expressado de genes contendo sequencias IRES foi analisado através do RT-qPCR e sua tradução ao longo do ciclo e em condições de estresse. Da expressão, não existe nenhuma diferença nos níveis de transcrição dos genes c-myc e xiap nas células normais e deficientes de DUSP3 em condições basais. Embora a síntese destas proteínas é maior nas células deficientes, mantendo um nível maior de tradução ao longo de todo o ciclo. Sob condições de estresse, esta duas proteínas sempre mantem uma maior expressão nas células Knockdown para DUSP3. Neste trabalho também foi estabelecido a presença de DUSP3 nos complexos da subunidade 40S, através do analise das frações obtidas do ensaio de polirribossomos e interação in vitro (Co-IP). A presença de DUSP3 nas subunidades 40S, os monossomas 80S e polissomos poderia ser através da interação direta com proteínas que possuem um domínio RRM e seria dependente dos complexos formados pelas proteínas e seus RNAs alvos. Aqui mostramos a interação in vitro de DUSP3 com a proteína PABP (com quatro domínios RRM), proteína que tem um papel importante na manutenção da taxa global de tradução, esta interação é enfraquecida na ausência de RNAs. A deficiência de DUSP3 também teria um impacto na interação das proteínas HNRNPC1/C2 e P53 in vitro. A ausência de DUSP3 diminui a interação HNRNPC-P53 através da hiperfosforilação da proteina HNRNPC1/C2. A perda desta interação, aumentaria os níveis da proteína P53 na célula deficiente de DUSP3 e poderia gerar parada no ciclo celular. Através de ensaios de imunofluorescência, se observo uma maior taxa de transcrição global na célula deficiente de DUSP3. Por fim, aqui demostramos que a interação direta de DUSP3 e HNRNPC1/C2 vai permitir a regulação das funções biológicas desta proteína, e a ausência de DUSP3 vai ter efeitos pleiotrópicos na homeostase da célula


inglêsProtein phosphorylation/dephosphorylation regulation is a central axis of many signaling cascades. DUSP3 phosphatase, consisting only of a single catalytic domain, plays key roles in cell proliferation and senescence. In HeLa cells subjected to genotoxic stress, DUSP3 physically interacts with HNRNPC proteins, but the effect of this molecular function is still unknown. Here we demonstrate that the absence of DUPS3 keeps the HNRNPC1/C2 proteins in a hyperphosphorylated state. To better understand the involvement of DUSP3- HNRNPC interaction on the biological functions of HNRNPC1/C2, DUSP3 deficient fibroblast cells were studied. The effect of DUSP3 deficiency on ribosome biogenesis was analyzed by polyribosome profile assay and RT-qPCR for rRNA quantification. The results showed that DUSP3 deficiency does not affect ribosomal subunit maturation, but would have an impact on transcription of pre-rRNAs and accumulation of 47S / 45S species. The expression of genes containing IRES sequences was analyzed by RT-qPCR and their translation throughout the cycle and under stress conditions. From expression, there is no difference in transcriptional levels of c-myc and xiap genes in normal and DUSP3 deficient cells under basal conditions. Although, the synthesis of these proteins is higher in deficient cells and these maintain a higher level of translation throughout the cell cycle. Under stress conditions, these two proteins always maintain higher expression in Knockdown cells for DUSP3. In this work, the presence of DUSP3 in the 40S ribosomal subunit complexes was also established by analyzing the fractions obtained from the polyribosome assay and in vitro interaction (CoIP). The presence of DUSP3 in the 40S subunits, 80S monosomes and polysomes could be through direct interaction with proteins that have an RRM domain and would be dependent on the complexes formed by the proteins and their target RNAs. Here we show the in vitro interaction of DUSP3 with PABP protein (with four RRM domains), a protein that plays an important role in maintaining the overall translation rate, this interaction is weakened in the absence of RNAs. DUSP3 deficiency would also have an impact on the interaction of HNRNPC1/C2 and P53 proteins in vitro. The absence of DUSP3 decreases HNRNPC-P53 interaction through hyperphosphorylation of the HNRNPC1/C2 proteins. Loss of this interaction would increase P53 protein levels in the DUSP3 deficient cell and could lead to cell cycle arrest. Through immunofluorescence assays, a higher overall transcription rate is observed in the DUSP3 deficient cell. Finally, we demonstrate that the direct interaction of DUSP3 and HNRNPC1/C2 will allow the regulation of the biological functions of this protein, and the absence of DUSP3 will have pleiotropic effects on cell homeostasis


Subject(s)
DNA Damage , Cell Cycle , Cells , Genes, myc , Origin of Life , Maintenance , Phosphorylation , Polyribosomes , Cell Cycle Checkpoints , Fibroblasts , Homeostasis
8.
São Paulo; s.n; s.n; 2020. 75 p. graf, tab.
Thesis in Portuguese | LILACS | ID: biblio-1290802

ABSTRACT

O kombucha é uma bebida fermentada tradicional, originária da China, preparada pela fermentação de chá preto adoçado com cultura mista de bactérias e leveduras chamada Simbiotic Culture of Bacteria and Yeast (SCOBY). Tem sido alegado que o mesmo possui propriedades funcionais, tais como recuperação ou manutenção de peso corporal, atividade antihiperglicêmica, entre outras. Por não existirem estudos suficientes que as comprovem, este trabalho teve por objetivo avaliar a influência do consumo de kombucha como tratamento alternativo para amenizar e/ou retardar sintomas e complicações do Diabetes Mellitus e identificar as possíveis modificações metabólicas, morfológicas e imunológicas ocorridas em camundongos com diabetes tipo 1. De acordo com os resultados obtidos, observou-se que, apesar de ter havido recuperação de massa corpórea próxima daquela que se tinha antes da indução da diabetes, esse efeito não foi exclusivo do kombucha e, embora a influência no controle glicêmico tenha sido maior nos camundongos normoglicêmicos que diabéticos, acredita-se que a administração por um período prolongado pudesse indicar melhores resultados, uma vez que as avaliações histológicas e morfométricas do intestino demonstraram resultados satisfatórios quanto ao aumento da superfície de mucosa e diminuição do infiltrado inflamatório, favorecendo a modulação imunológica. Logo, considera-se necessária a realização de mais trabalhos para comprovação da capacidade funcional do kombucha e elucidação de sua eficácia enquanto tratamento exclusivo e/ou complementar do diabetes


Kombucha is a traditional Chinese fermented beverage prepared by fermenting sweetened black tea with mixed bacterial and yeast culture called Simbiotic Culture of Bacteria and Yeast (SCOBY). It has been claimed that it has functional properties such as body weight recovery or maintenance, antihyperglycemic activity, among others. Because there are not enough studies to prove them, this study aimed to evaluate the influence of kombucha consumption as an alternative treatment to alleviate and/or delay symptoms and complications of Diabetes Mellitus and to identify possible metabolic, morphological and immunological changes in mice with type 1 diabetes. According to the results obtained, it was observed that, although there was a recovery of body mass close to the one obtained before diabetes induction, this effect was not unique to kombucha, and although the influence on glycemic control was greater in normoglycemic rather than diabetic mice, it is believed that administration over a prolonged period could indicate better results, since histological and morphometric evaluations of the intestine showed satisfactory results in terms of mucosal surface enlargement and decreased inflammatory infiltrate, favoring immune modulation. . Therefore, further work is considered necessary to prove the functional capacity of kombucha and to elucidate its effectiveness as an exclusive and / or complementary treatment of diabetes


Subject(s)
Animals , Mice , Diabetes Mellitus, Type 1/diagnosis , Kombucha Tea/analysis , Efficacy/classification , Diabetes Complications/complications , Functional Food/analysis , Fermented Foods and Beverages/adverse effects , Hypoglycemic Agents , Inflammation/prevention & control , Maintenance
9.
São Paulo; s.n; 2020. 76 p.
Thesis in Portuguese | LILACS | ID: biblio-1146487

ABSTRACT

O crescimento populacional no mundo, junto com o aumento desenfreado dos grandes centros urbanos, com condições precárias de saneamento e infraestrutura, favorecem o desenvolvimento e a proliferação de algumas espécies de mosquitos. O comportamento e fácil adaptação de Ae.aegypti favoreceram sua dispersão pelos mais diferentes tipos de ambientes, sendo encontrado principalmente no intra e peridomicílio, onde há elevada presença humana, abrigos e criadouros potenciais. As fêmeas possuem hábito alimentar diurno, sendo os picos de maior atividade no amanhecer e durante o crepúsculo vespertino. Entretanto, podem picar o homem e outros animais a qualquer hora do dia, pois são muito oportunistas. No Brasil, a grande importância de Ae. aegypti se dá ao fato de ser considerado o principal vetor da febre amarela urbana, dengue, chikungunya e Zika. Já o mosquito Culex quinquefasciatus geralmente está relacionado em áreas de saneamento precário, próximo às zonas periféricas. As fêmeas também são hematófagas e estão associadas aos locais de habitações humanas, onde encontram abrigo, criadouros e fontes de alimentação. Possuem hábitos noturnos e crepusculares e, eventualmente, podem picar durante o dia. A presença deste mosquito na área urbana gera desconforto ao ser humano, causando irritação e diminuição da qualidade de vida, devido ao incômodo causado pelas picadas e perturbação noturna. Além disso, algumas áreas infestadas por Cx. quinquefasciatus são propícias a problemas relacionados com saúde pública, pois esse mosquito é considerado vetor de agentes patogênicos, como a filaríase bancroftiana, causada pelo verme Wuchereria bancrofti. A manutenção de insetos em laboratório, assim como outros animais, possibilita entender melhor sua biologia, dinâmica de populações, desenvolvimento das espécies e melhores condições para confinamento e reprodução. Procedimentos de alimentação, reprodução e acondicionamento de mosquitos são alguns dos principais elementos para o desenvolvimento de colônias em larga escala em laboratório, além das condições ambientais, como temperatura, umidade e fotoperíodo. Formas imaturas de Ae. aegypti e Cx. quinquefasciatus podem ser mantidas para desenvolvimento nos mais variados tipos de recipientes. A manutenção de mosquitos adultos em laboratório é realizada através do confinamento destes insetos em gaiolas teladas, que podem variar de tamanho e material. A fonte alimentar para machos e fêmeas adultas de mosquitos se dá a partir de soluções açucaradas. Para reprodução de mosquitos em laboratório é essencial o fornecimento de alimentação sanguínea para fêmeas adultas, pois somente dessa forma haverá a maturação dos ovos. Alimentadores artificiais vêm sendo desenvolvidos e utilizados constantemente em procedimentos para manutenção de mosquitos em laboratório, sendo alguns mais complexos e outros mais simples. Estes alimentadores, normalmente, são compostos por um ou mais reservatórios sanguíneos, onde é estocado o volume de sangue para alimentação das colônias de insetos. Geralmente, estes reservatórios são cobertos por membranas finas que facilitam a penetração e alimentação dos mosquitos. Nesta revisão, foi observado que a maioria das técnicas para alimentação sanguínea artificial de mosquito, apresentaram bons resultados em relação a taxa de alimentação, fecundidade e sobrevivência dos insetos, sendo assim, uma boa alternativa para manutenção de colônias de Ae.aegypti e Cx.quinquefasciatus em laboratório.


The population increase in the world, with the increase in large urban areas, with poor sanitation and infrastructure conditions, favor the development and proliferation of some species of mosquitos. The behavior and easy adaptation of Ae. aegypti favored its dispersion in the most different types of environments, being found mainly within and around the home, where there is a high human presence, shelters and potential breeding sites. Females have diurnal eating habits, with the highest activity peaks at dawn and during evening twilight. However, they can bite man and other animals at any time of the day, as they are very opportunistic. In Brazil, the great importance of Ae. aegypti is due to the fact that it is considered the main vector of urban yellow fever, dengue, chikungunya and Zika. The Culex quinquefasciatus mosquito is generally found in areas of poor sanitation, near to peripheral areas. Females are also hematophagous and are associated with human habitation sites, where they find shelter, breeding grounds and source of food. They have nocturnal and twilight habits and, eventually, they can bite during the day. The presence of this mosquito in the urban area generates discomfort to humans, causing irritation and decreased quality of life, due to the discomfort caused by the bites and night disturbance. In addition, some areas infested by Cx. quinquefasciatus are conducive to problems related to public health, as this mosquito is considered a vector of pathogens, such as bancroftian phyliasis, caused by the Wuchereria bancrofti worm. The maintenance of insects in the laboratory, as well as other animals, makes it possible to better understand their biology, population dynamics, species development and the best conditions for confinement and reproduction. Procedures for feeding, breeding and conditioning mosquitos are some of the main elements for the development of large-scale colonies in the laboratory, in addition to environmental conditions such as temperature, whet and photoperiod. Immature forms of Ae. aegypti and Cx. quinquefasciatus can be kept for development in the most varied types of containers. The maintenance of adult mosquitoes in the laboratory is carried out by confining these insects in screened cages, which can vary in size and material. The food source for adult male and female mosquitoes is from sugary solutions. For reproduction of mosquitoes in the laboratory, it is essential to provide blood supply to adult females, as only in this way will the eggs mature. Artificial feeders have been developed and used constantly in procedures for maintenance mosquitos in the laboratory, some of which are more complex and others simpler. These feeders are usually composed of one or more blood reservoirs, where the volume of blood is stored to feed insect colonies. Generally, these depot are covered by thin membranes that facilitate the penetration and feeding of mosquitoes. In this review, it was observed that most techniques for artificial mosquito blood feeding, showed good results in relation to the feeding rate, fertility and survival of insects, this offer a good option for maintenance colonies of Ae.aegypti and Cx. quinquefasciatus in laboratory.


Subject(s)
Bottle Feeding , Aedes , Culex , Laboratories , Culicidae , Maintenance
10.
Article in English | WPRIM | ID: wpr-881506

ABSTRACT

@#BACKGROUND: Quality systematic reviews (SRs) are essential in the practice of evidence-based dermatology. We assessed the methodologic quality of SRs in dermatology from the Philippines. METHODS: We searched databases (MEDLINE, CDSR, PROSPERO, HERDIN; from inception until June 30, 2019), and secondary sources. We included SRs, authored by Filipino primary authors, which included clinical trials on any intervention for the treatment or prevention of a dermatologic disease or for maintenance of healthy skin, hair or nails. Two reviewers independently extracted data and appraised the methodological quality of each included SR using the AMSTAR 2. The 16-item AMSTAR 2 has 7 critical items and 9 non-critical items. The number of critical items mainly determine the overall confidence in the results of the review. Descriptive analysis using means and standard deviation for continuous data, and frequency and percentage distribution for categorical data were employed. RESULTS: Twenty SRs were included in this review, and were mostly published in the 2010s. Majority of SRs had three authors, who belonged to a single institution, with at least one dermatologist. The most common topic was infections and both oral and topical interventions were used. Majority had 5 included studies in the SRs, with a median number of 425 participants. The median number of critical flaws in the included SRs was 4.5, and non-critical flaws, 5. Overall confidence was critically low in majority (19/20 ) of included reviews, with only one review rated as low. CONCLUSION: The methodologic quality of the dermatology SRs from the Philippines based on the AMSTAR 2 tool was poor with a rating of critically low in majority. There is a need to improve quality of conduct and reporting through dissemination of the reporting guidelines such as the PRISMA


Subject(s)
Humans , Nails , Philippines , Dermatologists , Dermatology , Data Management , Data Collection , Publications , Maintenance , Reference Standards
11.
Article in Chinese | WPRIM | ID: wpr-828184

ABSTRACT

This paper introduces a fast repair methods of Versa HD volume-modulated accelerator's high voltage circuit fault:the key points test method. To identify five key points:①Enter maintenance mode to check for AFC deviation; ② The magnetron waveform MI and PFN waveform PFN V are detected on the maintenance terminal board; ③ Detect thyratron waveform; ④ Check the supply voltage of thyratron; ⑤ HT PSU 600 V DC test 600 V normal or not. The waveform or voltage is also measured to efficiently narrow the fault range to find out the cause of the fault, quickly remove the fault.


Subject(s)
Maintenance
12.
Article in Chinese | WPRIM | ID: wpr-772522

ABSTRACT

OBJECTIVE@#Aiming at the different characteristics of the various stages of medical equipment life cycle in hospital, research on the targeted and meticulous management mode.@*METHODS@#Divides the whole life cycle of medical equipment in hospital into four phases, which are the selection demonstration period, purchase acceptance period, maintenance period, and retirement disposal period, and comparison with human fetal period, infant stage, adult stage and old age.@*RESULTS@#With the meticulous management mode, the service quality of medical equipment in hospital has been improved, and the service benefits have been enhanced.@*CONCLUSIONS@#According to the respective characteristics of different stages, the corresponding meticulous management mode is implemented to make the management more scientific and standardized, and the operation is safer and more reliable, which escorts the whole life cycle of medical equipment in hospital.


Subject(s)
Equipment and Supplies, Hospital , Hospitals , Humans , Maintenance , Materials Management, Hospital
13.
Article in Chinese | WPRIM | ID: wpr-772521

ABSTRACT

In order to improve the quality of medical equipment after-sales service quality and improve the quality of medical equipment maintenance, this paper discusses the establishment of an evaluation index system to evaluate the quality of ultrasonic diagnostic equipment. From the three aspects of maintenance results, maintenance process and maintenance coverage, the quality of the post-maintenance quality of hospital ultrasound diagnostic equipment manufacturers is objectively evaluated.


Subject(s)
Commerce , Diagnostic Equipment , Equipment and Supplies, Hospital , Maintenance , Materials Management, Hospital
14.
Biosci. j. (Online) ; 34(3): 810-817, mai/jun. 2018.
Article in English | LILACS | ID: biblio-967009

ABSTRACT

The ICU is a highly complex sector, and among the wide range of interventions performed in the intensive care patient, we highlight the use of the central venous catheter (CVC). Maintaining the CVC requires knowledge and ability to ensure safe and long-lasting vascular access. However, during the permanence time of the device, some complications related to the catheter material, caliber, puncture site, dressing used, type of medication administered and length of stay may occur. Knowing the possible complications that occur with the catheter during its stay and the outcome of these complications favors the health professional in the elaboration of prevention strategies. Therefore, this research aims to elucidate the occurrence of non-elective removal, the main complications and outcomes related to the use of CVC in clients hospitalized in the ICU. This is a descriptive, observational, prospective study with a quantitative approach. The study was carried out in a teaching hospital in Uberaba-MG, from March to August 2016. The population of the study consisted of CVCs inserted in clients hospitalized in the ICUs. As a result, 75 (38.3%) catheters presented complications, being the outcome of 55 (73.3%) non-elective removal when the complication was discovered. The other 121 (61.7%) catheters had the outcome of removal on discharge from the client to the ward 59 (48.7%), death of the client 25 (20.6%), discharge from the client to the ward with the device (Risk benefit) 27 (22.3%) and removal at the physician's discretion 10 (8.2%). The permanence time of the device was 7.65. The greater the number of complications the catheter presented, the greater the chances of catheter loss (63.4). This study emphasizes the importance of conducting other studies that may contribute to the reduction of complications resulting from the use of CVC, and emphasize that complications demand higher expenses for the health system and increase the risk of infection of clients hospitalized in the ICU.


A UTI é um setor de alta complexidade, dentre a vasta gama de intervenções realizadas no cliente dentro da terapia intensiva destacamos o uso do cateter venoso central (CVC). A manutenção do CVC exige conhecimento e habilidade para garantir um acesso vascular seguro e duradouro. No entanto, durante o tempo de permanência do dispositivo algumas complicações relacionadas ao material do cateter, calibre, local de punção, curativo utilizado, tipo de medicamento administrado e tempo de permanência podem acontecer. Conhecer as possíveis complicações que ocorrem com o cateter durante a sua permanência e o desfecho dessas complicações favorece o profissional de saúde na elaboração de estratégias de prevenção. Diante disso, essa pesquisa tem por objetivo elucidar a ocorrência de retirada não eletiva, as principais complicações e os desfechos relacionados à utilização do CVC nos clientes internados na UTI. Trata-se de um estudo descritivo, observacional, prospectivo, com abordagem quantitativa. A pesquisa foi desenvolvida em um Hospital de ensino de Uberaba-MG no período de março a agosto de 2016. A população do estudo foi constituída por CVC inseridos em clientes internados nas UTI's. Como resultado 75 (38,3%) cateteres apresentaram complicações, onde o desfecho de 55 (73,3%) foi à retirada não eletiva frente à descoberta da complicação. Os outros 121 (61,7%) cateteres tiveram como desfecho a retirada na alta do cliente para enfermaria 59 (48,7%), o óbito do cliente 25 (20,6%), a alta do cliente para enfermaria com o dispositivo (risco benefício) 27 (22,3%) e a retirada a critério médico 10 (8,2%). O tempo de permanência do dispositivo foi de 7,65. Quanto maior foi o número de complicações que o cateter apresentou, maiores foram às chances de perda do cateter (63,4). Este estudo vem destacar a importância da realização de outras pesquisas que possam contribuir para redução de complicações advindas do uso do CVC, e ressaltar que as complicações demandam maiores gastos para o sistema de saúde e aumentam os riscos de infecção dos clientes internados na UTI.


Subject(s)
Device Removal , Central Venous Catheters , Intensive Care Units , Maintenance
15.
Braz. arch. biol. technol ; 61(spe): e18000440, 2018. tab
Article in English | LILACS | ID: biblio-974146

ABSTRACT

ABSTRACT The growing use of Photovoltaic Solar Energy in Brazil, both in power plants and in distributed generation systems, brings with it a series of practical and technical questions that are not limited to the design and project of the systems. Environmental factors and resources related to the use, operation, maintenance, decommissioning and final disposal of the equipment and components that constitute them, should be taken into consideration, so that these systems maintain an adequate performance during their lifespan granting the safety for users, properties and avoid negative environmental impacts. Within the concept of Risk Analysis within the Life Cycle of these systems, the present study addresses a perspective of the growth of the use of Solar Photovoltaic Energy in Brazil and the risks and impacts resulting from the lack of information on how good practices for a maintenance of its facilities, its performance, safety and sustainability of Photovoltaic Solar Power Generation Systems.


Subject(s)
Solar Energy , Photovoltaic Energy , Brazil , Reproducibility of Results , Maintenance
16.
Article in English | WPRIM | ID: wpr-149849

ABSTRACT

Sildenafil relaxes vascular smooth muscle cells and is used to treat pulmonary artery hypertension as well as erectile dysfunction. However, the effectiveness of sildenafil on skeletal muscle and the benefit of its clinical use have been controversial, and most studies focus primarily on tissues and organs from disease models without cellular examination. Here, the effects of sildenafil on skeletal muscle at the cellular level were examined using mouse primary skeletal myoblasts (the proliferative form of skeletal muscle stem cells) and myotubes, along with single-cell Ca2+ imaging experiments and cellular and biochemical studies. The proliferation of skeletal myoblasts was enhanced by sildenafil in a dose-independent manner. In skeletal myotubes, sildenafil enhanced the activity of ryanodine receptor 1, an internal Ca2+ channel, and Ca2+ movement that promotes skeletal muscle contraction, possibly due to an increase in the resting cytosolic Ca2+ level and a unique microscopic shape in the myotube membranes. Therefore, these results suggest that the maintenance ability of skeletal muscle mass and the contractility of skeletal muscle could be improved by sildenafil by enhancing the proliferation of skeletal myoblasts and increasing the Ca2+ availability of skeletal myotubes, respectively.


Subject(s)
Animals , Cytosol , Erectile Dysfunction , Hypertension , Maintenance , Male , Membranes , Mice , Muscle Fibers, Skeletal , Muscle, Skeletal , Muscle, Smooth, Vascular , Myoblasts, Skeletal , Pulmonary Artery , Ryanodine Receptor Calcium Release Channel , Sildenafil Citrate
17.
Rev. bras. ativ. fís. saúde ; 20(1): 57-64, jan. 2015. tab
Article in Portuguese | LILACS | ID: biblio-223

ABSTRACT

Objetivou-se analisar a autoeficácia (AE) para a prática de atividade física de idosos iniciantes em um programa de exercícios físicos (PEF). O PEF foi oferecido no contexto comunitário de Florianópolis - SC, durante três meses (três vezes/semana; 60 min/sessão) e foi conduzido por profissionais de Educação Física vinculados à rede de Atenção Primária à Saúde. Participaram do estudo 51 idosos (41 mulheres). A coleta de dados foi realizada por meio de questionários e envolveu variáveis sociodemográficas, percepção do estado de saúde e autoeficácia. Foram considerados "permanecentes" todos os idosos que participaram do PEF até o seu término e, "não permanecentes" aqueles que em algum momento deixaram de participar. Teste Qui-Quadrado ou Exato de Fisher foram utilizados para a comparação dos resultados, adotando nível de significância de 5%. Os principais resultados revelam que há diferenças da AE para a caminhada entre idosos permanecentes e não permanecentes do PEF (p=0,02), sendo superior entre os permanecentes. Além disso, a maioria dos avaliados percebe que o estado de saúde não dificulta a prática de AF. Os resultados obtidos sugerem que a AE contribuiu para a permanência de idosos no PEF e, dessa forma, sua avaliação no início de intervenções torna-se uma ferramenta importante no sentindo de desenvolver estratégias que auxiliem os participantes a incrementarem a percepção da AE.


The aim of this study was to analyze the self-efficacy (AE) for physical activity among elderly beginners in a physical exercise program (PEP). The PEP was offered in the community of Florianópolis - SC, during three months (three sessions per week, 60 min per session) and was conducted by physical education professionals affiliated with the Primary Care Network. The study included 51 elderly (41 women). Data collection was conducted through questionnaires and involved sociodemographic variables, perceived health status and AE. All elderly who participated in the PEP to its end were considered "persevering"; those who at some point stopped were considered "not persevering". Chi-square or Fisher's exact test were used to compare the results, adopting a significance level of 5%. The main results reveal that are differences of AE for the walk between "persevering" and "not persevering" elderly on PEP (p = 0.02), being higher among "persevering". Additionally, most of the participants evaluated perceive that the practice of AF is not prevented by state of health. The results suggest that SE contributed to the participants permanence in PEP and thus its evaluation in early intervention becomes an important tool in developing strategies that aid participants to increase the perception of AE.


Subject(s)
Humans , Male , Female , Aged , Adoption , Aged , Maintenance , Self Efficacy
18.
Article in Chinese | WPRIM | ID: wpr-310285

ABSTRACT

A Web-based technology system was put forward aiming at the actual problems of the long maintenance cycle and the difficulties of the maintenance and repairing of medical equipments. Based on analysis of platform system structure and function, using the key technologies such as search engine, BBS, knowledge base and etc, a platform for medical equipment service technician to use by online or offline was designed. The platform provides users with knowledge services and interactive services, enabling users to get a more ideal solution.


Subject(s)
Equipment and Supplies , Internet , Knowledge Bases , Maintenance
19.
Article in Chinese | WPRIM | ID: wpr-265634

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the effect of HIS hospital management system in medical equipment.</p><p><b>METHODS</b>From April 2012 to 2013 in our hospital 5 100 sets of medical equipment as the control group, another 2013 in our hospital from April 2014 may 100 sets of medical equipment as the study group, comparative analysis of two groups of medical equipment scrap rate, usage, maintenance score and the score of benefit etc.</p><p><b>RESULTS</b>Control group and taken to hospital information system, his research group equipment scrap rate, there was a significant difference, the research group of equipment maintenance score and efficiency scores were higher than those of the control group (P < 0.05), the study group of equipment maintenance score and efficiency scores were higher than those of the control group.</p><p><b>CONCLUSION</b>HIS hospital management system for medical equipment management has positive clinical application value, can effectively improve the use of medical equipment, it is worth to draw and promote.</p>


Subject(s)
Equipment and Supplies, Hospital , Hospital Administration , Hospital Information Systems , Maintenance
20.
Article in Chinese | WPRIM | ID: wpr-265610

ABSTRACT

Due to the high technology and the complexity of medical equipment, as well as to the safety and effectiveness, it determines the high requirements of the medical equipment maintenance work. This paper introduces some basic methods of medical instrument maintenance, including fault tree analysis, node method and exclusive method which are the three important methods in the medical equipment maintenance, through using these three methods for the instruments that have circuit drawings, hardware breakdown maintenance can be done easily. And this paper introduces the processing methods of some special fault conditions, in order to reduce little detours in meeting the same problems. Learning is very important for stuff just engaged in this area.


Subject(s)
Equipment and Supplies, Hospital , Reference Standards , Maintenance , Methods , Safety
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