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Article in English | WPRIM (Western Pacific) | ID: wprim-811118


BACKGROUND: In drug therapy for patients with arthritis, a naproxen/esomeprazole combination drug may be a tolerable choice because it can minimize gastrointestinal and cardiovascular adverse effects. The aim of this study was to investigate the changes in quality of life (QOL), medication adherence, and satisfaction after switch from the existing drug to the combination drug. In addition, we analyzed the correlation between the above-mentioned variables and the stratified demographic and medical data of the patients.METHODS: A prospective, noninterventional, observational study was conducted in 30 hospitals between May 2014 and July 2016. In total, 2,308 patients with osteoarthritis, 99 patients with rheumatoid arthritis, and 76 patients with ankylosing spondylitis were enrolled. Demographic information (age, sex, body mass index [BMI], alcohol consumption, and smoking) and medical information (type of arthritis, duration of disease, and comorbidities) were collected via a self-administered questionnaire. Patients were observed for more than three months after switching to the combination drug. Data on the QOL (EuroQoL 5-Dimension questionnaire [EQ-5D questionnaire]), medication adherence (Morisky Medication Adherence Scale [MMAS]), and satisfaction were collected at the first and last visits.RESULTS: A total of 2,483 patients enrolled at 30 hospitals completed the questionnaire. After the switch to the combination drug, the mean EQ-5D score improved from 0.72 ± 0.17 to 0.79 ± 0.14 (p < 0.001), and significant improvement was associated with female sex (p = 0.016), shorter disease duration (p < 0.001), and absence of comorbidities (p < 0.001). The mean MMAS score was 6.38 ± 1.77, indicating medium adherence. Satisfaction was significantly higher in female patients (p < 0.001), in patients with a shorter disease duration (p < 0.001), osteoarthritis (p = 0.003), and no comorbidities (p < 0.001). Serious drug-related adverse effects did not occur.CONCLUSIONS: The overall QOL was improved with medium adherence after the switch to the combination drug. On the basis of the analysis of stratified data, sex, age, drinking, smoking, disease duration, comorbidities, and BMI might be associated with QOL, satisfaction, and adherence.

Alcohol Drinking , Arthritis , Arthritis, Rheumatoid , Body Mass Index , Comorbidity , Drinking , Drug Therapy , Female , Humans , Medication Adherence , Naproxen , Observational Study , Osteoarthritis , Prospective Studies , Quality of Life , Smoke , Smoking , Spondylitis, Ankylosing
Article in English | WPRIM (Western Pacific) | ID: wprim-811066


PURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone propionate/formoterol treatment using a pressurized metered-dose inhaler [p-MDI group] vs. fluticasone propionate/salmeterol treatment using a dry powder inhaler [DPI group]) in older asthmatics.METHODS: We conducted a 12-week, randomized, open-label, parallel-designed trial in older patients (over 55 years old) with moderate-to-severe asthma, and compared the efficacy and safety for asthma control between the 2 groups. Subgroup analyses on disease duration and air trapping were performed. Clinical parameters, including changes in lung function parameters, inhaler technique and adherence, were compared with monitoring adverse reactions between the 2 groups.RESULTS: A total of 68 patients underwent randomization, and 63 (30 in the p-MDI group and 33 in the DPI group) completed this study. The p-MDI group was non-inferior to the DPI group with regard to the rate of well-controlled asthma (53.3% vs. 45.5%, P < 0.001; a predefined non-inferiority limit of 17%). In subgroup analyses, the proportion of patients who did not reach well-controlled asthma in the p-MDI group was non-inferior to that in the DPI group; the difference was 12.7% among those with a longer disease duration (≥ 15 years) and 17.5% among those with higher air-trapping (RV/TLC ≥ 45%), respectively (a predefined non-inferiority limit of 17%, P < 0.001). No significant differences were observed in lung function parameters, inhalation techniques, adherence and adverse reactions between the 2 groups.CONCLUSION: These results suggest that the p-MDI group may be comparable to the DPI group in the management of older asthmatics in aspects of efficacy and safety.

Airway Management , Asthma , Dry Powder Inhalers , Fluticasone , Humans , Inhalation , Lung , Medication Adherence , Metered Dose Inhalers , Nebulizers and Vaporizers , Random Allocation
Article in English | WPRIM (Western Pacific) | ID: wprim-811064


PURPOSE: Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is indispensable. This study aimed to investigate the clinical characteristics and outcomes of such patients.METHODS: A retrospective study was conducted on patients hospitalized for asthma exacerbation in 29 hospitals of 29 regions in mainland China during the period 2013 to 2014. Demographic features, pre-admission conditions, exacerbation details, and outcomes were summarized. Risk factors for exacerbation severity were analyzed.RESULTS: There were 3,240 asthmatic patients included in this study (57.7% females, 42.3% males). Only 28.0% used daily controller medications; 1,287 (39.7%) patients were not currently on inhaled corticosteroids. Acute upper airway infection was the most common trigger of exacerbation (42.3%). Patients with severe to life-threatening exacerbation tended to have a longer disease course, a smoking history, and had comorbidities such as hypertension, chronic obstructive pulmonary disease (COPD), and food allergy. The multivariate analysis showed that smoking history, comorbidities of hypertension, COPD, and food allergy were independent risk factors for more severe exacerbation. The number of patients hospitalized for asthma exacerbation varied with seasons, peaking in March and September. Eight patients died during the study period (mortality 0.25%).CONCLUSIONS: Despite enhanced education on asthma self-management in China during recent years, few patients were using daily controller medications before the onset of their exacerbation, indicating that more educational efforts and considerations are needed. The findings of this study may improve our understanding of hospital admission for asthma exacerbation in mainland China and provide evidence for decision-making.

Adrenal Cortex Hormones , Asthma , China , Comorbidity , Disease Progression , Education , Female , Food Hypersensitivity , Hospitalization , Humans , Hypertension , Inpatients , Medication Adherence , Mortality , Multivariate Analysis , Pulmonary Disease, Chronic Obstructive , Retrospective Studies , Risk Factors , Seasons , Self Care , Smoke , Smoking
REVISA (Online) ; 9(2): 199-211, 2020.
Article in Portuguese | LILACS (Americas) | ID: biblio-1099641


Objetivo: Avaliar autogestão de medicamentos em idosos, por meio de um aplicativo. Método: Pesquisa aplicada, transversal e mista, realizada com 15 idosos com idade igual a 69,45 (DP=6,55). As coletas ocorreram pré e após 60 dias de uso do aplicativo, sendo avaliados por meio do MEEM, questionário de pré-uso, questionário pós-uso e questionário sobre aspectos relativos à usabilidade do aplicativo. Para análise dos dados quantitativos, utilizaram-se análises descritivas do SPSS e, para os dados qualitativos, utilizou-se o software IRaMuTeQ. Resultados: Quanto à categorização da amostra, majoritariamente do sexo feminino (66,66%) e com baixa usabilidade (59,04). Os dados qualitativos no momento préuso apresentaram sete classes e a prevalência das palavras "Tomar" e "Medicamento". No momento pós-uso, foram observadas outras sete classes e a prevalência das palavras "Não" e "Aplicativo", indicando dificuldades no uso. Conclusão: Sugere-se que haja mais estudos que abordem questões relativas à interatividade, sobretudo acessibilidade e usabilidade, de forma a subsidiar a concepção e a construção de melhores aplicativos voltados para o público idoso.

Objective: To evaluate a self-administered drug in elderly, by an application. Method: Applied, cross and mixed research, performed with 15 elderly people with age equal to 69.45 (SD = 6.55). The collections occurred before and after 60 days of use of the application, being evaluated through the MMSE, pre-use questionnaire, post-use questionnaire and questionnaire on aspects related to the usability of the application. To analyze the quantitative data, SPSS descriptive analyzes were used, and for the qualitative data the software IRaMuTeQ was used. Results: Regarding the categorization of the sample, mostly female (66.66%) and with low usability (59.04). Qualitative data at the pre-use time presented seven classes and the prevalence of the words "take" and "Medication". At the post-use point, seven other classes and the prevalence of the words "No" and "Application" were observed, indicating difficulty in use. Conclusion: It is suggested that there be more studies that address issues related to interactivity, especially accessibility and usability, in order to subsidize the design and construction of better applications aimed at the elderly public.

Objetivo: evaluar el autocontrol de los medicamentos en los ancianos, utilizando una aplicación. Método: Investigación aplicada, transversal y mixta, realizada con 15 personas mayores de 69,45 años (DE = 6,55). Las recolecciones se realizaron antes y después de 60 días de uso de la aplicación, y se evaluaron mediante el MMSE, el cuestionario previo al uso, el cuestionario posterior al uso y el cuestionario sobre aspectos relacionados con la usabilidad de la aplicación. Para el análisis de los datos cuantitativos, se utilizaron análisis descriptivos del SPSS y, para los datos cualitativos, se utilizó el software IRaMuTeQ. Resultados: Respecto a la categorización de la muestra, mayoritariamente femenina (66,66%) y con baja usabilidad (59,04). Los datos cualitativos en el momento previo al uso presentaron siete clases y la prevalencia de las palabras "Tomar" y "Medicamento". En el momento posterior al uso, se observaron otras siete clases y la prevalencia de las palabras "No" y "Aplicación", lo que indica dificultades de uso. Conclusión: Se sugiere que haya más estudios que aborden temas relacionados con la interactividad, especialmente la accesibilidad y la usabilidad, para apoyar el diseño y la construcción de mejores aplicaciones dirigidas a las personas mayores.

Aged , Medication Adherence
Rev. Esc. Enferm. USP ; 54: e003538, 2020. tab, graf
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-1091965


Abstract Objective: To evaluate the effectiveness of home visits in a group of children and adolescents with severe asthma by using the inhalation technique score and adherence rates to drug treatment. Method: A 12-month randomized controlled trial involving patients aged between three and 17 years under regular follow-up treatment at a pediatric pulmonology outpatient clinic of a university hospital in southeastern Brazil. A group of patients received only outpatient consultations and the other group received home visits from nurses in addition to outpatient consultations. The differences between groups were analyzed through the outcomes of inhalation technique scores and treatment adherence rate. Results: Participation of 29 patients. In the intervention group, there was a statistically significant increase in inhalation technique scores (p<0.05) and elimination of critical errors between the first and the second evaluation, and results were maintained in the third evaluation. In the control group, there were no significant changes in inhalation technique scores. Rates of adherence to drug treatment in both groups did not rise. Conclusion: Home visits were effective for improving inhalation technique scores in patients with severe asthma. Brazilian Registry of Clinical Trials: RBR-8GZWZP.

Resumen Objetivo: Evaluar la efectividad de la visita domiciliaria en un grupo de niños y adolescentes con asma severa, utilizando el score de la técnica inhalatoria y las tasas de adhesión al tratamiento medicamentoso. Método: Estudio experimental randomizado controlado, con duración de 12 meses, que incluyó a pacientes con edades entre tres y 17 años, acompañados regularmente en un ambulatorio de neumología pediátrica de un hospital universitario de la región Sureste de Brasil. Un grupo de pacientes recibió solo consultas ambulatorias y el otro grupo, además de las consultas ambulatorias, recibió visitas de la enfermera en el hogar. Fueron analizadas las diferencias entre los grupos en los resultados: scores de la técnica inhalatoria y tasa de adhesión al tratamiento. Resultados: Participaron 29 pacientes. En el grupo intervención, hubo aumento estadísticamente significativo de los scores de la técnica inhalatoria (p<0,05) y eliminación de errores críticos de la primera a la segunda evaluación, resultados que se mantuvieron en la tercera. No hubo modificaciones significativas en la técnica inhalatoria del grupo de control. Las tasas de adhesión al tratamiento medicamentoso en ambos grupos no se elevaron. Conclusión: La visita domiciliaria fue eficaz en mejorar los scores de técnica inhalatoria en pacientes con asma severa. Registro Brasileño de Ensayos Clínicos: RBR-8GZWZP

Resumo Objetivo: Avaliar a eficácia da visita domiciliar, em um grupo de crianças e adolescentes com asma grave, utilizando o escore da técnica inalatória e as taxas de adesão ao tratamento medicamentoso. Método: Estudo experimental randomizado controlado, com duração de 12 meses, envolvendo pacientes, com idades entre três e 17 anos, acompanhados regularmente em um ambulatório de pneumologia pediátrica de um hospital universitário da região Sudeste do Brasil. Um grupo de pacientes recebeu apenas consultas ambulatoriais e o outro grupo, além das consultas ambulatoriais, recebeu visitas da enfermeira no domicílio. Foram analisadas as diferenças entre os grupos nos desfechos: escores da técnica inalatória e taxa de adesão ao tratamento. Resultados: Participaram 29 pacientes. No grupo-intervenção, houve aumento estatisticamente significante dos escores da técnica inalatória (p<0,05) e eliminação de erros críticos da primeira para a segunda avaliação, resultados que foram mantidos na terceira. Não houve alterações significativas na técnica inalatória do grupo-controle. As taxas de adesão ao tratamento medicamentoso em ambos os grupos não se elevaram. Conclusão: A visita domiciliar foi eficaz em melhorar os escores de técnica inalatória em pacientes com asma grave. Registro Brasileiro de Ensaios Clínicos: RBR-8GZWZP.

Humans , Child, Preschool , Child , Adolescent , Asthma/drug therapy , Asthma/therapy , Inhalation , Medication Adherence , House Calls
Evid. actual. práct. ambul ; 22(3): e002021, nov. 2019.
Article in Spanish | LILACS (Americas) | ID: biblio-1047108


Una joven de 23 años con asma leve intermitente se presenta a la consulta médica. Se plantea cuál es la mejor alternativa para su tratamiento: el uso de broncodilatadores de acción corta a demanda (SABA, por sus iniciales en inglés) o de broncodilatadores de acción rápida en asociación con corticoides inhalatorios (ICS/FABA, por sus iniciales en inglés) a demanda. Tras revisar la bibliografía se encontraron una revisión sistemática y dos ensayos clínicos que indican que los ICS/FABA serían superiores a los SABA; sin embargo este efecto fue solamente estudiado en casos de asma persistente.Es importante discutir estos hallazgos con los pacientes, junto a sus implicancias económicas, incorporando sus valores y preferencias a la hora de tomar una decisión terapéutica. (AU)

A 23-year-old woman with mild intermittent asthma comes to the doctor's office. The best alternative for treatment is considered: the use of short-acting bronchodilators on demand (SABA) or fast-acting bronchodilators in association with inhaled corticosteroids (ICS/FABA) on demand. After a literature search, a systematic review and two clinical trials werefound, which indicate that the ICS/FABA would be superior to the SABA; however, this effect was only studied in cases of persistent asthma. It is important to discuss these findings with the patients, alongside with their economic implications,incorporating their values and preferences when making a therapeutic decision.

Humans , Female , Infant , Adult , Young Adult , Asthma/drug therapy , Bronchodilator Agents/therapeutic use , Asthma/diagnosis , Asthma/etiology , Asthma/epidemiology , Signs and Symptoms, Respiratory , Socioeconomic Factors , Bronchodilator Agents/administration & dosage , Bronchiolitis , Respiratory Sounds , Adrenal Cortex Hormones/therapeutic use , Cough , Decision Making , Dyspnea , Medication Adherence
Arch. Clin. Psychiatry (Impr.) ; 46(4): 85-88, July-Aug. 2019. tab
Article in English | LILACS (Americas) | ID: biblio-1019344


Abstract Background Impact of illness may vary with the medication adherence which in turn may vary with the attitude towards drugs. There is a paucity of research examining relationships between these variables. Objective To study the levels of drug attitude, adherence and its relationship with the impact of illness. Methods A total of 279 participants with mental illness in remission were assessed with socio-demographic and clinical proforma, scales like Hogan Drug Attitude Inventory (DAI), Impact of Illness Scale (IIS), and Morisky Medication Adherence Scale (MMAS) were used. Result Mean score on DAI, IIS, and MMAS were 2.38 (SD = 4.6), 25.88 (SD = 6.6), and 5.04 (SD = 2.2) respectively. On linear regression analysis (R2 = .122, DF = 2, F = 17.598, p < .001) IIS Score was statistically significant but negatively associated with the score of MMAS (p < .05) and DAI (p < .05). Discussion Impact of illness has an inverse relationship with the level of drug attitude and medication adherence. Improving drug attitude and adherence may buffer the impact of illness.

Humans , Male , Female , Adult , Middle Aged , Medication Adherence/psychology , Mental Disorders/drug therapy , Cross-Sectional Studies , Sickness Impact Profile , Disease-Free Survival , India
Rev. pesqui. cuid. fundam. (Online) ; 11(4): 962-967, jul.-set. 2019. tab
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-1005814


Objetivos: Descrever as características dos casos de abandono do tratamento de tuberculose em pacientes que desenvolveram tuberculose multirresistente (TBMR). Métodos: Estudo descritivo de abordagem quantitativa, desenvolvido em uma instituição terciária de referência para tratamento de TBMR localizada na cidade do Rio de Janeiro. Foi utilizado instrumento estruturado com informações de quarenta prontuários entre os meses de agosto a dezembro de 2016. A análise dos dados foi realizada por meio do software SPSS. Resultados: Dos pacientes estudados, 35% abandonaram tratamento anterior de tuberculose. Conclusão e implicação para a prática: É necessária a identificação precoce de pacientes que apresentam maior risco para abandono do tratamento, bem como a criação de um modelo de assistência voltado ao perfil dos usuários que abandonam o tratamento, com uma prática participativa, com grupos educativos que promovam ações preventivas, identificando e estudando estratégias para a superação de barreiras ligadas à realidade de vida individual e coletiva

Objective: To describe the characteristics of cases of tuberculosis treatment abandonment in patients who developed MDR-TB. Methods: a descriptive study of a quantitative approach developed in a tertiary referral institution for the treatment of MDR-TB, located in the city of Rio de Janeiro. A structured instrument was used with information from forty medical records between August and December 2016. Data analysis was performed using SPSS software. Results: Of the patients studied, 35% abandoned previous treatment of tuberculosis. Conclusion and implication for the practice: early identification of patients who are at greater risk for treatment abandonment is required, as well as the creation of a model of assistance aimed at the profile of users who abandon treatment, with a participatory practice with educational groups That promote preventive actions, identifying, studying strategies for overcoming barriers linked to reality, individual and collective life

Objetivos: Describir las características de los casos de abandono del tratamiento de tuberculosis en pacientes que desarrollaron TBMR. Métodos: estudio descriptivo de abordaje cuantitativo, desarrollado en una institución terciaria de referencia para tratamiento de TBMR, ubicado en la ciudad de Río de Janeiro. Se utilizó instrumento estructurado con informaciones de cuarenta prontuarios entre los meses de agosto a diciembre de 2016. El análisis de los datos fue realizado a través del software SPSS. Resultados: de los pacientes estudiados, el 35% abandonó el tratamiento anterior de la tuberculosis.Conclusión e implicación para la práctica: es necesaria la identificación precoz de pacientes que presentan mayor riesgo para el abandono del tratamiento, así como la creación de un modelo de asistencia orientado al perfil de los usuarios que abandonan el tratamiento, con una práctica participativa, con grupos educativos Que promuevan acciones preventivas, identificando, estudiando estrategias para la superación de barreras ligadas a la realidad, de vida individual y colectiva

Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Patient Dropouts/statistics & numerical data , Tuberculosis, Multidrug-Resistant/drug therapy , Tuberculosis, Multidrug-Resistant/therapy , Medication Adherence/statistics & numerical data
Medicina (Ribeiräo Preto) ; 52(3)jul.-set. 2019.
Article in Portuguese | LILACS (Americas) | ID: biblio-1025540


RESUMO Modelo de estudo: Trata-se de um estudo do tipo observacional, descritivo e transversal. Objetivo: Avaliar o comportamento de adesão ao tratamento antirretroviral de pessoas convivendo com HIV/aids que participam de um Grupo de Adesão. Métodos: O questionário foi respondido por 15 pacientes maiores de 18 anos, independente do sexo, com diagnóstico confirmado de AIDS que participam de um Grupo de Adesão em um serviço de dispensação de antirretrovirais, e que após receberem informações pertinentes ao estudo, aceitaram participar voluntariamente, por meio da assinatura do Termo de Consentimento Livre e Esclarecido. Resultado: A maioria dos participantes era do sexo masculino, acima de 40 anos (73,3%) e 26,6% eram economicamente ativos. Quanto à sexualidade, 80% dos entrevistados declararam ser heterossexual. Quanto à escolaridade, 60% não havia completado o ensino médio. O tempo de diagnóstico da doença predominante foi entre 10 e 16 anos, sendo que 46,6% referiram possuir outros problemas de saúde, como toxoplasmose, herpes, tuberculose e leishmaniose. A análise do questionário de adesão mostrou que 33,3% possuía uma boa adesão ao tratamento antirretroviral. Entre as interações droga-droga identificadas, 44,4% ocorreram entre os antirretrovirais. Conclusão: A partir da realização deste estudo foi possível concluir que 66,66% dos entrevistados relataram que em algum momento houve uma descontinuidade do tratamento, revelando uma dificuldade na manutenção do uso dos antirretrovirais em indivíduos convivendo com HIV/AIDS. No contexto da farmacoepidemiologia antirretroviral, as potenciais interações medicamentosas identificadas neste estudo foram eventos que afetam a resposta terapêutica levando a toxicidade (AU)

Study design: This is an observational, descriptive, and cross-sectional study. Objective: Evaluating the adher-ence behavior to the antiretroviral treatment of people living with HIV/Aids who participate in an Adherence Group. Methods: The questionnaire was answered by 15 patients older than 18 years of age, regardless of sex, with a confirmed diagnosis of AIDS participating in an Adherence Group at an antiretroviral dispensing service, who, after receiving information related to the study, agreed to participate voluntarily, by singing the Written Informed Consent Form. Results: The majority of the participants were male, over 40 years old (73.3%) and 26.6% were economically active. Regarding sexuality, 80% of the interviewees stated that they were heterosexual. As for schooling, 60% had not finished high school. The time of diagnosis of the disease predominant was between 10 and 16 years, and 46.6% reported having other health problems, like toxoplasmosis, herpes, tuberculosis, and leishmaniasis. The analysis of the adherence questionnaire showed that 33.3% had good adherence to antiretroviral treatment. Among the drug-drug interactions identified, 44.4% occurred among antirretrovirals. Conclusion: Based on this study, it was possible to conclude that 66,66% at some point there was a discontinuation of treatment, revealing a difficulty in maintaining antiretroviral use in individuals living with HIV/aids. In the scenario of antiretroviral pharmacoepidemiology, the po-tential drug interactions identified in this study were events that affect the therapeutic response leading to toxicity (AU)

Humans , Male , Female , Adult , HIV Infections , Acquired Immunodeficiency Syndrome , Pharmacoepidemiology , Anti-HIV Agents , Medication Adherence
J. bras. nefrol ; 41(2): 224-230, Apr.-June 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1012538


Abstract Introduction: Hyperphosphatemia is a serious consequence of chronic kidney disease and has been associated with an increased risk for cardiovascular disease. Controlling serum phosphorus levels in patients on dialysis is a challenge for the clinicians and implies, in most cases, the use of phosphate binders (PB). Part of the reason for this challenge is poor adherence to treatment because of the high pill burden in this patient group. Objective: To assess the real-world effectiveness of sucroferric oxyhydroxide (SO) in controlling serum phosphorus levels and determine the associated pill burden. Methods: A multicenter, quantitative, retrospective, before-after study was conducted with patients receiving online hemodiafiltration. Patients who switched to SO as a part of routine care were included in the study. PB treatment, number of pills, serum phosphorus levels, and intravenous iron medication and dosage were collected monthly during the six months of treatment with either PB or SO. Results: A total of 42 patients were included in the study. After switching from a PB to SO, the prescribed pills/day was reduced 67% from 6 pills/day to 2 pills/day (p < 0.001) and the frequency of pill intake was lowered from 3 times/day to 2 times/day (p < 0.001). During the treatment with SO, the proportion of patients with serum phosphorus ≤ 5.5 mg/dL increased from 33.3% at baseline to 45% after six months of treatment. Conclusion: During the six-month follow-up with SO, serum phosphorus levels were controlled with one third of the pills/day compared to other PB.

Resumo Introdução: A hiperfosfatemia é uma grave consequência da doença renal crônica associada a risco aumentado de doença cardiovascular. O controle dos níveis séricos de fósforo dos pacientes em diálise é um desafio que requer, na maioria dos casos, o uso de quelantes de fosfato (QF). Parte da dificuldade se deve à baixa adesão ao tratamento oriunda do grande número de medicamentos receitados para esse grupo de pacientes. Objetivo: Avaliar a real eficácia do oxihidróxido sucroférrico (OHS) no controle dos níveis séricos de fósforo e determinar a carga de comprimidos associada. Métodos: Estudo multicêntrico, quantitativo, retrospectivo, antes e depois conduzido com pacientes em hemodiafiltração on-line. Pacientes remanejados para OHS como parte dos cuidados de rotina foram incluídos no estudo. Tratamento com QF, número de comprimidos, níveis séricos de fósforo, reposição férrica endovenosa e dosagens foram registrados mensalmente durante seis meses de tratamento com QF ou OHS. Resultados: Foram incluídos 42 pacientes no estudo. Após a mudança de QF para OHS, o número de comprimidos prescritos por dia caiu em 67%, de seis para duas unidades diárias (p < 0,001). A frequência de ingestão de comprimidos caiu de três para duas vezes ao dia (p < 0,001). Durante o tratamento com OHS, o percentual de pacientes com fósforo sérico ≤ 5,5 mg/dL aumentou de 33,3% no início para 45% após seis meses de tratamento. Conclusão: Durante os seis meses de seguimento com OHS, os níveis séricos de fósforo foram controlados com um terço dos comprimidos por dia em relação aos tratamentos com outros QF.

Humans , Male , Female , Adult , Middle Aged , Aged , Sucrose/therapeutic use , Ferric Compounds/therapeutic use , Hemodiafiltration , Hyperphosphatemia/drug therapy , Phosphorus/blood , Retrospective Studies , Follow-Up Studies , Treatment Outcome , Drug Combinations , Renal Insufficiency, Chronic/complications , Hyperphosphatemia/etiology , Medication Adherence , Sevelamer/adverse effects , Sevelamer/therapeutic use
Rev. pesqui. cuid. fundam. (Online) ; 11(3): 555-559, abr.-maio 2019. tab
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-987456


Objetivo: Conhecer a adesão dos idosos às formas de administração do tratamento da tuberculose. Métodos: Estudo exploratório-descritivo, transversal e quantitativo, desenvolvido no Distrito Sanitário Oeste de Natal, com os idosos que fizeram tratamento entre janeiro de 2010 a dezembro de 2015. Resultados: Observou-se que os idosos utilizam tanto o regime autoadministrado (51,1%) quanto o diretamente observado (48,9%). Em ambos os grupos prevaleceu a faixa etária de 60 a 69 anos (29,8%; 35,1%), a forma pulmonar da doença (41,5%; 44,7%) e o caso novo como tipo de entrada para o tratamento (31,9%; 27,7%). Quanto ao encerramento, destacou-se a conclusão do tratamento (33,0%; 25,5%). Conclusão: A tuberculose ainda é prevalente no Brasil, destacando-se a importância do diagnóstico e tratamento adequados, além da adoção de medidas de controle e capacitação dos profissionais de saúde frente ao cuidado desses pacientes

The study's purpose has been to know the adherence of elderly people to the different forms of management of tuberculosis treatment. Methods: It is a descriptive-exploratory and cross-sectional study with a quantitative approach that was carried out in the Western Sanitary District at Natal city, and counted with elderly patients who underwent treatment from January 2010 to December 2015. Results: It was observed that the elderly people use both the self-administered regimen (51.1%) and directly observed (48.9%). In both groups the participants were within the age group from 60 to 69 years old (29.8%, 35.1%), the pulmonary form of the disease (41.5%, 44.7%) prevailed, and the new case as the type of entry for the treatment (31.9%, 27.7%). Regarding the treatment termination, the accomplishment of the treatment conclusion was highlighted among the studied cases (33.0%, 25.5%). Conclusion: Tuberculosis is still prevalent in Brazil, highlighting the importance of both adequate diagnosis and treatment, as well as the adoption of measures to control and train health professionals with regards to the care of these patients

Objetivo: Conocer la adhesión de los ancianos a las formas de administración del tratamiento de la tuberculosis. Métodos: Estudio exploratoriodescriptivo, transversal y cuantitativo, desarrollado en el Distrito Sanitario Oeste de Natal, con los ancianos que hicieron tratamiento entre enero de 2010 a diciembre de 2015. Resultados: Se observó que los ancianos utilizan tanto el régimen autoadministrado (51, 1%) como el directamente observado (48,9%). En ambos grupos prevaleció el grupo de edad de 60 a 69 años (29,8%, 35,1%), la forma pulmonar de la enfermedad (41,5%, 44,7%) y el caso nuevo como tipo de entrada para El tratamiento (31,9%, 27,7%). En cuanto al cierre, se destacó la conclusión del tratamiento (33,0%, 25,5%). Conclusión: La tuberculosis sigue siendo prevalente en Brasil, destacándose la importancia del diagnóstico y tratamiento adecuados, además de la adopción de medidas de control y capacitación de los profesionales de salud frente al cuidado de esos pacientes

Humans , Male , Female , Aged , Tuberculosis/therapy , Tuberculosis/epidemiology , Medication Adherence/statistics & numerical data , Health Services for the Aged/statistics & numerical data
Rev. APS ; 22(2): 235-250, 20190401.
Article in Portuguese | LILACS (Americas) | ID: biblio-1102798


A Unidade Básica de Saúde (UBS) e a Estratégia de Saúde da Família (ESF) são dois modelos diferentes de assistência na Atenção Primária à Saúde. Objetivou-se comparar o grau de adesão a terapêutica medicamentosa de indivíduos com hipertensão assistidos em Estratégia de Saúde da Família (ESF) e Unidade Básica de Saúde (UBS). O estudo teve a participação de 63 indivíduos da ESF e 51 da UBS. Aplicou-se questionários para identificar o perfil da população e avaliar a adesão (teste de Morisky-Green ­ TMG). Utilizou-se estatística descritiva e, para a análise de associação, os testes Goodman e odds ratio. As variáveis idade, sexo feminino e sedentarismo apresentaram-se homogêneas em ambos os grupos. Entre as variáveis estudadas, apenas a idade mostrou diferença significante, pois pessoas com menos de 60 anos demonstraram menor adesão ao tratamento. Houve diferença significativa na adesão ao tratamento medicamentoso (ESF > UBS). Conclui-se que a melhor adesão foi na ESF, mas ambas foram consideradas abaixo do desejado.

The Basic Health Unit (UBS) and the Family Health Strategy (ESF) are two different models of assistance in the Primary Health Care (APS). The objective was to compare therapeutic drug adherence degree in hypertension persons in Family Health Strategy (ESF) and Health Centers (UBS). There were 63 participants from the Family Health Strategy and 51 from the Health Centers. A profile identification questionnaire and a Morisky-Green test (MGT) were used. Descriptive statistic was used and Goodman and Odds Ratio tests were applied for association analyses. Variables as age, female gender and sedentarism were homogeneous in both groups. Among the variables, only age was significantly different, meaning that persons under 60 years of age has have lower rate of adherence to treatment. There was a significative difference in the adhesion (ESF > UBS).

Treatment Adherence and Compliance , Hypertension , Primary Health Care , Health Programs and Plans , Health Centers , Health Knowledge, Attitudes, Practice , Health Education , Family Health Strategy , Medication Adherence , Hypertension/prevention & control
Rev. argent. reumatol ; 30(1): 28-34, mar. 2019. graf, tab
Article in Spanish | LILACS (Americas) | ID: biblio-1013377


Objetivo: Este estudio se propone evaluar el cumplimiento del tratamiento farmacológico en pacientes con AR e identificar los factores que pueden afectar al mismo. Materiales y métodos: Estudio observacional, analítico, transversal. Se realizaron encuestas a 176 pacientes de la base de datos, seleccionados al azar de un centro privado especializado en Reumatología ubicado en el conurbano sur de la provincia de Buenos Aires (Instituto Médico CER - Quilmes). Entre septiembre de 2015 y julio de 2016 fueron realizadas de manera telefónica por voluntarios no médicos de la Fundación Articular entrenados a tal fin. Se utilizaron los cuestionarios BAM, CQR19 y se indagó la percepción del paciente sobre su grado de adhesión al tratamiento dividiéndolo en dos grupos: cumplimiento total o cumplimiento parcial/nulo. Se recabaron datos sociodemográficos, estado de enfermedad, tratamiento, comorbilidades y hábitos. Se utilizaron las siguientes pruebas estadísticas: ANOVA de un factor para evaluar diferencias en niveles medios de CQR19 y variables cualitativas; prueba de Brown-Forsythe para determinar asociación entre CRQ y diversas variables, correlación no paramétrica Rho de Spearman entre CQR19 y variables cuantitativas y regresión logística para explicar adherencia al tratamiento (CQR19 agrupada). Los datos fueron analizados usando el programa SPSS (versión 19.0). Resultados: El 85,8% eran mujeres y la edad promedio fue de 55,1 años. El 51,1% de los pacientes considera que su salud es buena con relación a la AR y el 40,9% considera que es regular. El tratamiento más frecuente fue MTX oral (79%). La monoterapia fue la modalidad terapéutica más referida (79,5%) y el tiempo medio de tratamiento es de 4,4 años. La actitud de los pacientes hacia los medicamentos mostró acuerdo en los 5 ítems que corresponden a la dimensión necesidad del BAM. El nivel de acuerdo-desacuerdo resultó más heterogéneo en los ítems de la dimensión preocupación. CQR19 mostró alto nivel de acuerdo en la mayor parte de los ítems positivos y alto nivel de desacuerdo en la mayor parte de los ítems negativos. Las únicas variables que se asociaron a mayor CQR fueron la presencia de comorbilidades (Brown-Forsythe=7,960; p=0,005) y medicación concomitante (Brown-Forsythe=7,529; p=0,007). También se encontró asociación significativa entre CRQ19 y tabaquismo (F=0,019; p=0,981). Se observó correlación significativa entre CQR y BAM Específico-Necesidad (Rho=0,379; p <0,001) y entre CQR y BAM Específico-Preocupación (Rho=-0,188; p=0,012). Se observó mayor adherencia cuando el paciente siente la necesidad de cumplir con la medicación (O.R.=1,342; p=0,012) y cuando menos preocupado está por la misma (O.R.=0,870; p=0,047). Detectamos menor cumplimiento del tratamiento en pacientes casados o que viven en pareja (Chi²=7,448; p=0,024) y con mayor nivel educativo (Chi²=6,313; p=0,043). Cuando se evalúa el cumplimiento de la medicación prescrita por indagación directa a los pacientes, el nivel de cumplimiento es más elevado. Conclusión: Se trata de una población con nivel moderado de adherencia. Mayor conciencia de necesidad de medicación y menor nivel de preocupación acerca de la misma generan mayor adherencia. Los pacientes sobreestiman el cumplimiento de la medicación cuando se los interroga de manera directa por lo cual es mandatorio utilizar otro método de evaluación. El mayor conocimiento de la adherencia de los pacientes con AR nos permitirá desarrollar herramientas que mejoren este aspecto a largo plazo.

Objective: This study aims to evaluate the compliance of pharmacological treatment in patients with RA and identify the factors that may affect it. Materials and methods: Observational, analytical and cross-sectional study. Surveys were conducted on 176 randomly selected patients from a private center specialized in Rheumatology located in the southern suburbs of the province of Buenos Aires (CER Medical Institute - Quilmes), between September 2015 and July 2016, by telephone by trained non-medical volunteers of the Articular Foundation. The BAM, CQR19 questionnaires were used and the patient's perception of their degree of adherence to the treatment was investigated, dividing it into two groups: total compliance or partial/no compliance. Sociodemographic data, disease status, treatment, comorbidities and habits were collected. The following statistical tests were used: one-way ANOVA to evaluate differences in mean levels of CQR19 and qualitative variables; Brown-Forsythe test to determine the association between CRQ and various variables, non-parametric Spearman's Rho correlation between CQR19 and quantitative variables and logistic regression to explain adherence to treatment (CQR19 grouped). The data was analyzed using the SPSS program (version 19.0). Results: 85.8% were women and the average age was 55.1 years. 51.1% of patients consider that their health is good in relation to RA and 40.9% consider it to be fair. The most frequent treatment was oral MTX (79%). Monotherapy was the most referred therapeutic modality (79.5%) and the mean treatment time is 4.4 years. The attitude of the patients towards the medicines showed agreement in the 5 items that correspond to the dimension of necessity of the BAM. The level of agreement-disagreement was more heterogeneous in the items of the concern dimension. CQR19 showed a high level of agreement in most of the positive items and a high level of disagreement in most of the negative items. The only variables that were associated with higher CQR were the presence of comorbidities (Brown-Forsythe=7.960, p=0.005) and concomitant medication (Brown-Forsythe=7.529, p=0.007). There was also a significant association between CRQ19 and smoking (F=0.019, p=0.981). Significant correlation was observed between CQR and BAM Specific-Necessity (Rho=0.379, p <0.001) and between CQR and BAM Specific-Concern (Rho=-0.188; p=0.012). Greater adherence was observed when the patient felt the need to comply with the medication (O.R.=1.342, p=0.012) and when least concerned about it (O.R.=0.870, p=0.047). We detected less compliance with treatment in married patients or those living with a partner (Chi²=7.448, p=0.024) and with a higher educational level (Chi²=6.313, p=0.043). When the compliance of the prescribed medication is evaluated by direct inquiry to the patients, the level of compliance is higher. Conclusion: It is a population with a moderate level of adherence. Greater awareness of the need for medication and a lower level of concern about it generate greater adherence. Patients overestimate medication compliance when they are interrogated directly, which is why it is mandatory to use another evaluation method. The greater knowledge of the adherence of patients with RA will allow us to develop tools that improve this aspect in the long term.

Arthritis, Rheumatoid , Therapeutics , Medication Adherence
Nursing (Säo Paulo) ; 22(249): 2600-2603, fev.2019.
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-995998


A hipertensão arterial sistêmica é o principal fator de risco para doenças cardiovasculares. O descontrole, em grande parte, está associado a não adesão ao tratamento. OBJETIVO: Associar a adesão ao tratamento medicamento e a qualidade de vida de pacientes hipertensos. MÉTODO: Estudo descritivo, transversal, quantitativo, realizado em uma Unidade Básica de Saúde da Família do interior da Paraíba. RESULTADOS: Abordaram-se 140 hipertensos, grande parte da amostra apresentou sobrepeso e score de qualidade de vida 12,18. A principal queixa foi cefaleia, com 27,7, onde a maioria está com baixo score de adesão (17,8). Em relação aos fatores de risco modificáveis, a maior parte da amostra é sedentária, com score de adesão baixo de 45,5. Quanto às doenças, o diabetes mellitus é mais frequente, com score baixo de 22,3. CONCLUSÃO: Destaca-se a baixa adesão terapêutica, sendo necessária a identificação dos fatores que podem impelir negativamente, para proporcionar uma assistência mais efetiva.(AU)

Systemic arterial hypertension is the main risk factor for cardiovascular diseases. Lack of control, in large part, is associated with non-adherence to treatment. OBJECTIVE: To associate adherence to medication treatment and quality of life of hypertensive patients. METHOD: Descriptive, cross - sectional, quantitative study carried out at a Basic Family Health Unit in the interior of Paraíba. RESULTS: 140 hypertensive patients were approached, a large part of the sample was overweight and had a quality of life score 12,18. The main complaint was headache, with 27.7, where the majority had low adherence score (17.8). Regarding the modifiable risk factors, most of the sample is sedentary, with a low adhesion score of 45.5. As for diseases, diabetes mellitus is more frequent, with a low score of 22.3. CONCLUSIONS: Low therapeutic adherence is highlighted, and it is necessary to identify the factors that can negatively influence, to provide a more effective assistance.(AU)

La hipertensión arterial sistémica es el principal factor de riesgo para las enfermedades cardiovasculares. El descontrol, en gran parte, está asociado a la no adhesión al tratamiento. OBJETIVO: Asociar la adhesión al tratamiento medicamento y la calidad de vida de pacientes hipertensos. MÉTODO: Estudio descriptivo, transversal, cuantitativo, realizado en una Unidad Básica de Salud de la Familia del interior de Paraíba. RESULTADOS: Se abordaron 140 hipertensos, gran parte de la muestra presentó sobrepeso y score de calidad de vida 12,18. La principal queja fue cefalea, con 27,7, donde la mayoría está con bajo score de adhesión (17,8). En cuanto a los factores de riesgo modificables, la mayor parte de la muestra es sedentaria, con una puntuación de adhesión baja de 45,5. En cuanto a las enfermedades, la diabetes mellitus es más frecuente, con una puntuación baja de 22,3. CONCLUSIONES: Se destaca la baja adhesión terapéutica, siendo necesaria la identificación de los factores que pueden impulsar negativamente, para proporcionar una asistencia más efectiva.(AU)

Humans , Primary Health Care , Quality of Life , Medication Adherence , Hypertension , Risk Factors
Nursing (Säo Paulo) ; 22(248): 2560-2564, jan.2019.
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-979709


A Hipertensão Arterial Sistêmica (HAS) é considerada uma condição multifatorial, caracterizada pela elevação dos níveis de Pressão Arterial (PA). Objetivou-se identificar os fatores que dificultam a adesão ao tratamento medicamentoso da HAS. Obteu-se uma amostra por 20 artigos que atenderam aos critérios de inclusão. Os principais aspectos que influenciam na adesão do tratamento medicamentoso da HAS estão relacionados ao indivíduo, que envolvem o déficit cognitivo, baixa escolaridade, sentimentos de incapacidade, alcoolismo, socioeconômicos, aceitação da doença e esquecimento; ao tratamento, alto custo dos medicamentos, longa duração e complexidade do tratamento, efeitos adversos e número de medicamentos; à doença, complicações tardias, assintomatologia, condições da doença e cronicidade, serviços de saúde, insuficiência de informação, dificuldades no acesso e habilidade deficiente dos profissionais para ensinar o uso correto dos medicamentos. O estudo possibilitou verificar que diversos fatores interferem na adesão e continuidade do tratamento medicamentoso da HAS, devendo ser abordados pelos profissionais de saúde.(AU)

Humans , Chronic Disease , Medication Adherence , Hypertension , Risk Factors
Rev. APS ; 22(1)20190101.
Article in Portuguese | LILACS (Americas) | ID: biblio-1102636


O objetivo deste trabalho foi avaliar o conhecimento sobre a terapia anticoagulante antes e depois da aplicação de um vídeo educativo em pacientes ambulatoriais em uso de varfarina atendidos por um hospital público. O conhecimento dos pacientes foi avaliado por seis perguntas, sendo calculado o percentual de respostas certas. Identificou-se os pacientes com percentual de acerto ≥ 60%, e para avaliar o conhecimento adquirido com o vídeo foi determinado o acerto antes e depois da visualização para a pergunta sobre qual é a indicação da varfarina. A análise estatística univariada e os testes MacNemer e Mann­Witney foram realizadas no SPSS 21.0. O vídeo foi avaliado por 62 pacientes, sendo que 41 (66,1%) tinham até seis meses de tratamento. O conhecimento sobre a indicação da varfarina aumentou após o vídeo (p = 0,006). Não houve diferença significativa entre o percentual de acertos considerando tempo de tratamento ≥ 6 meses ou < 6 meses (p = 0,775). O vídeo ajudou a esclarecer dúvidas sobre anticoagulação de 98,4% dos pacientes. Os resultados sugerem que o material audiovisual elaborado pode contribuir para ampliar o conhecimento sobre o tratamento com varfarina e, consequentemente, proporcionar aumento das taxas de adesão ao tratamento com anticoagulante e aumentar a segurança dos pacientes.

This paper aims to evaluate the knowledge of anticoagulant therapy before and after application of an educational video in outpatients using warfarin under the care of a public hospital. The knowledge of the patients was evaluated with six questions by calculating the percentage of correct answers. The patients with a ≥ 60% percentage of correct answers were identified and to assess the knowledge acquired with the video, the amount of correct answers to the question of what is the warfarin indicate was determined before and after the video. Univariate statistical analysis and MacNemer and Mann-Whitney tests were performed with SPSS 21.0. The video was rated by 62 patients, from which 41 (66.1%) had up to six months of treatment. Knowledge of the indication of warfarin increased after the video (p = 0.006). There was no significant difference between the percentage of correct answers of patients considering treatment time ≥6 months and <6 months (p = 0.775). The video helped answer questions about anticoagulation from 98.4% of the patients. The results suggest that the elaborated audiovisual material can help to expand knowledge about treatment with warfarin and thus provide increased adherence rates to anticoagulation treatment and increase patient safety.

Warfarin , Medication Adherence , Health Knowledge, Attitudes, Practice , Health Education , Drug Therapy , Treatment Adherence and Compliance , Anticoagulants
Rev. Soc. Cardiol. Estado de Säo Paulo ; 29(1 (Supl)): 72-77, jan.-mar. 2019. tab
Article in Portuguese | LILACS (Americas) | ID: biblio-1015121


Avaliar o impacto das crenças em saúde no controle da pressão arterial de idosos hipertensos em um município com elevado índice de desenvolvimento humano (IDHM), considerando sexo e classe social. Metodologia: O estudo foi realizado nas Unidades Básicas de Saúde do município de São Caetano do Sul. Foram coletadas informações sociodemográficas por meio de questionário. Aferiu-se a PA para a identificação dos pacientes hipertensos controlados e não controlados. Utilizou-se escala de crenças em saúde com sentenças sobre crenças de barreiras e benefícios relacionados a cada um dos treze comportamentos de saúde referentes às medidas de prevenção e controle da hipertensão arterial. Realizou-se análise descritiva e razão de prevalência, considerando significância para p ≤ 0,05. Resultados: Observamos que a maioria dos pacientes aderiu ao tratamento, tendo noção dos benefícios de controlar os fatores de risco de hipertensão. Conclusão: Concluímos que os dados foram semelhantes entre homens e mulheres e a classe social impactou inversamente na adesão ao tratamento medicamentoso

To assess the impact of health beliefs on blood pressure control in hypertensive elderly patients in a municipality with a high human development index (HDI), considering sex and social class. Methodology: The study was carried out at the Basic Health Units of the municipality of São Caetano do Sul. Sociodemographic information was collected through a questionnaire. BP was measured to identify controlled and uncontrolled hypertensive patients. A health belief scale with judgments on the perceived barriers and benefits related to each of the thirteen health behaviors corresponding to hypertension prevention and control measures was used. A descriptive analysis was conducted and a prevalence ratio calculated, considering significance for p ≤0.05. Results: We observed treatment adherence in the majority of patients, who were aware of the benefits of controlling the risk factors for hypertension. Conclusion: We concluded that the data were similar between men and women, and that social class had an inverse impact on compliance with drug treatment

Humans , Male , Female , Middle Aged , Aged , Health of the Elderly , Hypertension , Cardiovascular Diseases/mortality , Prevalence , Surveys and Questionnaires , Risk Factors , Age Factors , Outcome Assessment, Health Care/methods , Medication Adherence , Observational Study
Enferm. foco (Brasília) ; 10(1): 02-06, jan. 2019. tab, graf
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1028045


Objetivo: Identificar os fatores intervenientes para a não adesão de usuários da terapia com anticoagulante oral na manutenção da faixa terapêutica. Metodologia: Estudo transversal realizado com 607 pacientes, realizado em Centro de Anticoagulação Oral em Hospital Público de Cardiologia. Os dados foram coletados através de um formulário entre 2014-2015, e analisados estatisticamente por testes de comparação e associação. Resultados: Identificaram-se 52% sexo feminino, 57% casados, faixa etária maior que 60 anos 62%, ensino fundamental incompleto 42%, provenientes de São Paulo 93%. Na análise multivariada obtiveram-se como significativas; escolaridade, renda familiar, uso inadequado, interação medicamentosa, procedimentos invasivos, interações alimentar, atividade física, condições clínicas, outros fatores e complicações próprias do uso do medicamento. Conclusão: O estudo apresentou-se com alto valor preditivo mediante os fatores intervenientes de não adesão e possibilitou as tomadas de decisões direcionadas para o problema pelo enfermeiro, propondo escore de melhoria para a adesão e manutenção na faixa ideal.

Objective: to identify the factors involved to the non-adherence of oral anticoagulant therapy users in the maintenance of the therapeutic range. Methodology: this cross-sectional study conducted with 607 patients held in centre of Oral anticoagulation in public Hospital of cardiology. The data were collected through form between 2014-2015, and statistically analyzed for comparison and Association tests. Results: 52% were female, 57% married, age greater than 60 years 62%, 42%, incomplete basic education from São Paulo 93%. In multivariate analysis significant were obtained; education, family income, misuse, drug interaction, invasive procedures, food interactions, physical activity, clinical conditions, other factors and complications specific to the use of the medicine. Conclusion: the study had a high predictive value by the participating factors of non-adherence an allowed the nurse to make decisions for the problem proposing an improvement score for the adherence, and maintenance in the ideal range.

Objetivo: identificar los factores involucrados a la no adherencia de los usuarios de la terapia anticoagulante oral en el mantenimiento de la gama terapéutica. Metodología: este estudio transversal realizado con 607 pacientes llevó a cabo en el centro de la anticoagulación Oral en el Hospital público de Cardiología. Los datos fueron recogidos através de un formulario entre 2014-2015 y se analizaron estadísticamente para comparaciones o pruebas de asociación. Resultados: 52% eran mujer, 57% había casado, edad mayor de 60 años 62%, 42%, educación básica incompleta de São Paulo 93%. En análisis multivariante significativas se obtuvieron; Educación, ingreso familiar, mal uso, interacción de medicamentos, procedimientos invasivos, interacciones de alimentos, actividad física, condiciones clínicas, otros factores y complicaciones específicas para el uso de la medicina. Conclusión: este estudio mostró alto valor predictivo mediante lós factores de intervención de no adesion y posibilito las tomadas de decisiones direccionadas para el problema por el enfermero y propone puntuación mejora de membresía y mantenimiento en el rango ideal.

Male , Female , Humans , Medication Adherence , Anticoagulants , Cardiology , Nursing