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1.
Chinese journal of integrative medicine ; (12): 18-24, 2024.
Article in English | WPRIM | ID: wpr-1010297

ABSTRACT

OBJECTIVE@#To assess the outcomes after acupoint application in patients with pharyngeal pain in a real-world settings, and analyze the characteristics of effective population and prescription characteristics of acupoint application.@*METHODS@#Based on CHUNBO platform, patients with pharyngeal pain who were candidates for acupoint application on the basis of physician-evaluation, were enrolled in a nationwide, prospective, 69-week multicenter observational study from August 2020 to February 2022. Propensity score matching (PSM) was used to match the confounding factors and the association rules were used to analyze the characteristics of effective population and prescription characteristics of acupoint application. Outcome assessments included the disappearance rate of pharyngeal pain (within 3, 7, and 14 days), disappearance time of pharyngeal pain, as well as adverse events.@*RESULTS@#Of 7,699 enrolled participants, 6,693 (86.9%) received acupoint application and 1,450 (21.7%) with non-acupoint application. After PSM, there were 1,004 patients each in the application group (AG) and non-application group (NAG). The disappearance rate of pharyngeal pain in the AG at 3, 7, and 14 days were all higher than those in the NAG (P<0.05). The disappearance time of pharyngeal pain in the AG were shorter than that in the NAG (logrank P<0.001, hazard ratio=1.51, 95% confidence interval: 1.41-1.63). The median age of effective cases was 4 years, mainly 3-6 years old (40.21%). The disappearance rate of pharyngeal pain in the application group with tonsil diseases was 2.19 times higher than that in the NAG (P<0.05). The commonly used acupoints for the effective cases were Tiantu (RN 22), Shenque (RN 8) and Dazhui (DU 14). The commonly used herbs for the effective cases were Natrii sulfas, Radix et Rhizoma Rhei, and Herba Ephedrae. Among them, Natrii sulfas was applied to RN 8 most frequently (support 84.39%). A total of 1,324 (17.2%) patients experienced AEs, and mainly occurred in the AG, with significant difference in the incidence of AEs between goups (P<0.05). All AEs reported were the first grade, and the average regression days of AEs was 2.8 days.@*CONCLUSIONS@#Acupoint application in patients with pharyngeal pain resulted in improved effective rate and shortened duration, especially children aged 3-6 years old, and those with tonsil diseases. Acupoint of RN 22, RN 8 and DU 14, Natrii sulfas, Radix et Rhizoma Rhei, and Herba Ephedrae were the most commonly used herbs in the treatment of pharyngeal pain.


Subject(s)
Child , Humans , Child, Preschool , Acupuncture Points , Medicine, Chinese Traditional/methods , Prospective Studies , Pain
2.
Chinese journal of integrative medicine ; (12): 1045-1056, 2023.
Article in English | WPRIM | ID: wpr-1010308

ABSTRACT

Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment, representing the forefront of antitumor research. However, studies on immune checkpoint molecules have mainly focused on targeted therapies. Chinese medicine (CM) research as a complementary medicine has revealed that immune checkpoint molecules also undergo disease-specific changes in the context of autoimmune diseases. This review article presents a comprehensive analysis of CM studies on immune checkpoint molecules in the last 5 years, with a focus on their role in different diseases and treatment modalities. CM research predominantly utilizes oral administration of herbal plant extracts or acupuncture techniques, which stimulate the immune system by activating specific acupoints through temperature and needling. In this study, we analyzed the modulation and mechanisms of immune checkpoint molecules associated with different coinhibitory and costimulatory molecules, and reviewed the immune functions of related molecules and CM studies in treating autoimmune diseases and tumors. By summarizing the characteristics and research value of CM in regulating immune checkpoint molecules, this review aims to provide a useful reference for future studies in this field.


Subject(s)
Humans , Medicine, Chinese Traditional/methods , Immune Checkpoint Proteins , Acupuncture Therapy/methods , Neoplasms/pathology , Autoimmune Diseases
3.
Biomedical and Environmental Sciences ; (12): 1068-1078, 2023.
Article in English | WPRIM | ID: wpr-1007882

ABSTRACT

OBJECTIVE@#To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of "people with the five elements in traditional Chinese medicine (TCM)."@*METHODS@#Data collected from the literature review, two sessions of brainstorming of experts with related experience in "people with the five elements in TCM" from October 2020 to December 2020, and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed. Triangulation was used in this study, and theming and synthesizing were used to analyze the data.@*RESULTS@#A total of 31 experts and 30 interviewees participated in this study. The median age of the experts and interviewees were 48.0 and 38.5 years, respectively; 51.66% and 54.8% of experts and interviewees, respectively, were men. The descriptors of facial diagrams of "people with the five elements in TCM" were complexion, shape, distribution state of facial bones, convergence trend of facial muscles, and facial expression. A theoretical model of "people with the five elements in TCM" was shaped based on these findings.@*CONCLUSION@#The study suggests a possibility for bridging the gap between personality and bodily state, identifying an avenue for personality research from the perspective of TCM.


Subject(s)
Female , Humans , Male , Adult , Middle Aged , Medicine, Chinese Traditional/methods , Diagnosis , Projective Techniques
4.
Journal of Integrative Medicine ; (12): 528-536, 2023.
Article in English | WPRIM | ID: wpr-1010962

ABSTRACT

As one of the key components of clinical trials, blinding, if successfully implemented, can help to mitigate the risks of implementation bias and measurement bias, consequently improving the validity and reliability of the trial results. However, successful blinding in clinical trials of traditional Chinese medicine (TCM) is hard to achieve, and the evaluation of blinding success through blinding assessment lacks established guidelines. Taking into account the challenges associated with blinding in the TCM field, here we present a framework for assessing blinding. Further, this study proposes a blinding assessment protocol for TCM clinical trials, building upon the framework and the existing methods. An assessment report checklist and an approach for evaluating the assessment results are presented based on the proposed protocol. It is anticipated that these improvements to blinding assessment will generate greater awareness among researchers, facilitate the standardization of blinding, and augment the blinding effectiveness. The use of this blinding assessment may further advance the quality and precision of TCM clinical trials and improve the accuracy of the trial results. The blinding assessment protocol will undergo continued optimization and refinement, drawing upon expert consensus and experience derived from clinical trials. Please cite this article as: Wang XC, Liu XY, Shi KL, Meng QG, Yu YF, Wang SY, Wang J, Qu C, Lei C, Yu XP. Blinding assessment in clinical trials of traditional Chinese medicine: Exploratory principles and protocol. J Integr Med. 2023; 21(6): 528-536.


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Medicine, Chinese Traditional/methods , Outcome Assessment, Health Care , Reference Standards , Reproducibility of Results , Research Design , Clinical Trials as Topic
5.
Journal of Integrative Medicine ; (12): 407-412, 2023.
Article in English | WPRIM | ID: wpr-1010958

ABSTRACT

The global coronavirus disease 2019 (COVID-19) pandemic has had a massive impact on global social and economic development and human health. By combining traditional Chinese medicine (TCM) with modern medicine, the Chinese government has protected public health by supporting all phases of COVID-19 prevention and treatment, including community prevention, clinical treatment, control of disease progression, and promotion of recovery. Modern medicine focuses on viruses, while TCM focuses on differential diagnosis of patterns associated with viral infection of the body and recommends the use of TCM decoctions for differential treatment. This differential diagnosis and treatment approach, with its profoundly empirical nature and holistic view, endows TCM with an accessibility advantage and high application value for dealing with COVID-19. Here, we summarize the advantage of and evidence for TCM use in COVID-19 prevention and treatment to draw attention to the scientific value and accessibility advantage of TCM and to promote the use of TCM in response to public health emergencies. Please cite this article as: Huang M, Liu YY, Xiong K, Yang FW, Jin XY, Wang ZQ, Zhang JH, Zhang BL. The role and advantage of traditional Chinese medicine in the prevention and treatment of COVID-19. J Integr Med. 2023; 21(5): 407-412.


Subject(s)
Humans , Asian People , COVID-19/prevention & control , Diagnosis, Differential , Medicine, Chinese Traditional/methods , Pandemics/prevention & control
6.
Biomedical and Environmental Sciences ; (12): 441-451, 2023.
Article in English | WPRIM | ID: wpr-981072

ABSTRACT

OBJECTIVE@#Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha - a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies - yet remaining almost entirely unexplored by the modern-day high-throughput methods of the -omics sciences.@*METHODS@#We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.@*RESULTS@#We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.@*CONCLUSION@#The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.


Subject(s)
Humans , Medicine, Chinese Traditional/methods , Histones , Gene Expression
7.
Chinese Journal of Medical Instrumentation ; (6): 89-92, 2023.
Article in Chinese | WPRIM | ID: wpr-971310

ABSTRACT

This study briefly introduces the tongue diagnostic equipment of traditional Chinese medicine. It analyzes and discusses the key points of technical evaluation of tongue diagnostic equipment from the aspects of product name, performance parameters, image processing functions, product use methods, clinical evaluation, etc. It analyzes the safety risks and effectiveness indicators of tongue diagnostic equipment, hoping to bring some help to the gradual standardization of tongue diagnostic equipment and the registration of enterprises.


Subject(s)
Medicine, Chinese Traditional/methods , Tongue , Image Processing, Computer-Assisted , Diagnostic Equipment , Reference Standards
8.
China Journal of Orthopaedics and Traumatology ; (12): 809-814, 2023.
Article in Chinese | WPRIM | ID: wpr-1009141

ABSTRACT

Objective To explore the short-term efficacy of digitally-assisted traditional Chinese medicine manual reduction combined with 3D printed splint in the treatment of AO type-A distal radius fractures, and explore the quantification of traditional Chinese medicine manual reduction and personalized improvement of splinting. Methods The clinical data of 50 patients with AO type-A distal radius fractures, who received treatment at the outpatient department of Cangzhou Integrated Traditional Chinese and Western Medicine Hospital in Hebei Province, were retrospective analyzed. The patient cohort included 22 females and 28 males, with ages ranging from 25 to 75 years old. Among them, 27 cases presented with distal radius fractures on the left side, and 24 cases on the right side. The patients were categorized into two groups: treatment group (n=25) and control group(n=25). There were 13 males and 12 females in the treatment group, with an average age of (56.2±5.5) years old. Treatment approach for this group involved several steps. Initially, Mimics Research software was used to conduct comprehensive analysis of complete CT data from the affected limb, resulting in the creation of a three-dimensional model. Subsequently, 3D models of the bones and skin contours, stored as STL format files, were imported into the Materialise Magics 23.0 software for model processing and repair. This facilitated the simulation of reduction and recording of displacement data, effectively generating a "digital prescription" to guide and quantify traditional Chinese medicine manipulation procedures. Finally, a personalized 3D printed splint was applied for fixation treatment. There were 15 males and 10 females in the control group, with an average age of (53.32±5.28) years old. These patients were treated with manualreduction combined with traditional splinting. The clinical efficacy of the two groups was assessed in terms of fracture reduction quality, fracture healing time, Gartland-Werley wrist joint score and X-ray parameters (palminclination angle, ulnar deviation angle, radius height) at 6 weeks post-operatively. Results The treatment group exhibited a shorter duration for achieving clinical healing compared to the control group (P<0.05). Six weeks post-operatively, the treatment group demonstrated higher wrist joint function scores, and a higher proportion of excellent and good outcomes than the control group(P<0.05). The treatment group was superior to the control group in terms of imaging parameters 6 weeks post-operatively (P<0.05). Conclusion By quantifying skin contours through digital simulation prescription reduction, a personalized 3D printed splint is developed to effectively stabilize fractures, enhancing localized fixation while ensuring greater adherence, stability, and comfort. This innovative approach offers personalized treatment for AO type-A distal radius fractures and presents a novel, precise treatment strategy for consideration.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , East Asian People , Printing, Three-Dimensional , Retrospective Studies , Splints , Wrist Fractures/therapy , Medicine, Chinese Traditional/methods , Therapy, Computer-Assisted/methods , Manipulation, Orthopedic/methods , Tomography, X-Ray Computed , Precision Medicine/methods
9.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 481-493, 2022.
Article in English | WPRIM | ID: wpr-939913

ABSTRACT

TCM formulae are the important guidances for clinical application of traditional Chinese medicines, which follow the principles of diagnosis and treatment in TCM. Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines. With the rapid development of modern instruments and technology, many new theories, methods and strategies are emerging, which upgrade the research of TCM formulae into a higher level. Only when the medicinal efficacy, bio-active components, function mechanism of TCM formulae are understood, we can guarantee TCM safety and quality control. In this paper, we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study, serum pharmacology and serum pharmacochemistry, association analysis, biochromatography, network pharmacology, metabolomics and proteomics, so as to provide reference for the research and development of TCM in the future.


Subject(s)
Biological Products , Drugs, Chinese Herbal/chemistry , Medicine, Chinese Traditional/methods , Metabolomics , Proteomics
10.
Journal of Integrative Medicine ; (12): 402-415, 2022.
Article in English | WPRIM | ID: wpr-939899

ABSTRACT

BACKGROUND@#Traditional Chinese medicine (TCM) is becoming a popular complementary approach in pediatric oncology. However, few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.@*OBJECTIVE@#We explored the patterns of TCM use and its efficacy in children with cancer, using a systematic review, meta-analysis and data mining study.@*SEARCH STRATEGY@#We conducted a search of five English (Allied and Complementary Medicine Database, Embase, PubMed, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov) and four Chinese databases (Wanfang Data, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and VIP Chinese Science and Technology Periodicals Database) for clinical studies published before October 2021, using keywords related to "pediatric," "cancer," and "TCM."@*INCLUSION CRITERIA@#We included studies which were randomized controlled trials (RCTs) or observational clinical studies, focused on patients aged < 19 years old who had been diagnosed with cancer, and included at least one group of subjects receiving TCM treatment.@*DATA EXTRACTION AND ANALYSIS@#The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool, respectively. Meta-analysis was used to evaluate the efficacy of combining TCM with chemotherapy. Study outcomes included the treatment response rate and occurrence of cancer-related symptoms. Association rule mining (ARM) was used to investigate the associations among medicinal herbs and patient symptoms.@*RESULTS@#The 54 studies included in this analysis were comprised of RCTs (63.0%) and observational studies (37.0%). Most RCTs focused on hematological malignancies (41.2%). The study outcomes included chemotherapy-induced toxicities (76.5%), infection rate (35.3%), and response, survival or relapse rate (23.5%). The methodological quality of most of the RCTs (82.4%) and observational studies (80.0%) was rated as "moderate." In studies of leukemia patients, adding TCM to conventional treatment significantly improved the clinical response rate (odds ratio [OR] = 2.55; 95% confidence interval [CI] = 1.49-4.36), lowered infection rate (OR = 0.23; 95% CI = 0.13-0.40), and reduced nausea and vomiting (OR = 0.13; 95% CI = 0.08-0.23). ARM showed that Radix Astragali, the most commonly used medicinal herb (58.0%), was associated with treating myelosuppression, gastrointestinal complications, and infection.@*CONCLUSION@#There is growing evidence that TCM is an effective adjuvant therapy for children with cancer. We proposed a checklist to improve the quality of TCM trials in pediatric oncology. Future work will examine the use of ARM techniques on real-world data to evaluate the efficacy of medicinal herbs and drug-herb interactions in children receiving TCM as a part of integrated cancer therapy.


Subject(s)
Adult , Child , Humans , Young Adult , China , Combined Modality Therapy , Complementary Therapies , Data Mining , Drugs, Chinese Herbal/therapeutic use , Medicine, Chinese Traditional/methods , Observational Studies as Topic , Randomized Controlled Trials as Topic
11.
Braz. J. Pharm. Sci. (Online) ; 58: e201157, 2022. tab, graf
Article in English | LILACS | ID: biblio-1403735

ABSTRACT

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a network pharmacology-based approach was used to systematically explore the intrinsic mechanisms of TXYF in IBD at the molecular level. Network pharmacology-based methods, which mainly included database mining, screening of bioactive compounds, target prediction, collection of IBD-related targets, gene enrichment analysis, network construction, and molecular docking, were employed in the present study. Network analysis revealed a total of 108 potential targets derived from 22 component compounds of TXYF, among which 34 targets were common with the IBD-related targets. In the protein-protein interaction (PPI) network, 10 key targets were identified. The gene enrichment analysis suggested that anti-inflammatory processes, such as NF-kappa B signaling pathway and Toll-like receptor signaling pathway, could be the core processes involved in the action of TXYF in IBD. Molecular docking results revealed that three compounds present in TXYF exhibited strong binding affinity for PTGS2. The present study provides novel insights into the molecular mechanisms and network approaches of TXYF action in IBD from a systemic perspective. The potential targets and pathways identified in the present study would assist in further research on the clinical application of TXYF in IBD therapy.


Subject(s)
Inflammatory Bowel Diseases/pathology , Intestines/abnormalities , Medicine, Chinese Traditional/methods , NF-kappa B , Toll-Like Receptors , Network Pharmacology/instrumentation
12.
Acta cir. bras ; 37(2): e370205, 2022. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1374067

ABSTRACT

Purpose: To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire. Methods: Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised mice models. Results: In vitro, total extract, as well as chloroform, ethyl acetate, n-butanol and water fractions could individually enhance the phagocytic ability of mouse peritoneal macrophages; in addition, chloroform and ethyl acetate fractions had an increasing tendency when combined stimulation with lipopolysaccharide (LPS). In vivo, ethyl acetate fraction (EAF) could enhance the immune organ index, increase the serum hemolysin level and peripheral blood immune cells of immunocompromised mice, while for normal mice, the effect was inconspicuous. Conclusions: Blaps rynchopetera extracts had noteworthy immunomodulatory effect, especially for individuals with immune disorders.


Subject(s)
Animals , Mice , Coleoptera/chemistry , Immunocompromised Host , Immunologic Factors/analysis , Medicine, Chinese Traditional/methods , Macrophages
13.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 184-190, Jan.-Feb. 2021. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1153063

ABSTRACT

Concern with antimicrobial resistance in animal production systems increases the interest toward integrative therapies. The objective of the present report was to report an integrative approach to a goat undergoing rumenotomy. A goat with ruminal acidosis underwent rumenotomy, corrective rumen suture, moxibustion, and treatment of the surgical wound (TFO) with sugar. In the first twenty days, acupuncture was performed on ST36, indirect moxibustion on Sp6 and CV8, and TFO with antibiotic ointment and sugar. The wound contracted 2cm, there was gradual return of ruminal dynamics, and moderate pain. Acupuncture continued from D21 to D50 on Yin tang, BL13, BL20, BL23, and BL22. Although there was drainage of ruminal fluid, the wound contracted 4cm during this period, pain was absent, and ruminal dynamics normal. During the last thirty days, the acupuncture technique surround the dragon was used and BL13 point needled, with complete closure of the wound. The TFO from D21 was performed solely with sugar. During treatment, there was modulation of the inflammatory response, with formation of granulation tissue and neovascularization. On D84, fibrinogen was 100mg/dL. The authors conclude that the use of sugar, acupuncture, and moxibustion contributed to return of normal ruminal motility, wound contraction, and complete tissue reepithelization.(AU)


A preocupação com a resistência antimicrobiana nos sistemas de produção animal aumenta o interesse pelas terapias integrativas. Objetiva-se relatar a abordagem integrativa ao paciente caprino submetido à ruminotomia. Uma cabra com acidose ruminal foi submetida à ruminotomia, ruminorrafia, moxabustão, acupuntura e tratamento da ferida operatória (TFO) com açúcar. Nos primeiros vinte dias realizou-se acupuntura em ST36, moxa indireta em Sp6 e CV8, TFO com pomada antibiótica e açúcar. A ferida contraiu 2cm, houve retorno gradual da dinâmica ruminal e dor moderada. A acupuntura continuou de D21 a D50 em Yin tang, BL13, BL20, BL23 e BL22. Apesar da ferida drenar fluido ruminal teve contração de 4cm nesse período, ausência de dor e retorno fisiológico da dinâmica ruminal. Nos últimos trinta dias foi realizada a técnica de acupuntura cercar o dragão e punturou-se o ponto BL13, com fechamento completo da ferida. O TFO a partir do D21 foi realizado somente com açúcar. Durante tratamento houve modulação da resposta inflamatória com formação de tecido de granulação e neoangiogênesse, o D84 revelou fibrinogênio 100mg/dL. Conclui-se que a utilização do açúcar, acupuntura e moxabustão contribuíram para o retorno fisiológico da motilidade ruminal, contração da ferida e completa reepitelização tecidual.(AU)


Subject(s)
Animals , Rumen/surgery , Acidosis/veterinary , Ruminants , Goats , Surgical Wound/therapy , Rumen/diagnostic imaging , Acupuncture Therapy/veterinary , Medicine, Chinese Traditional/methods , Moxibustion/veterinary
14.
Journal of Integrative Medicine ; (12): 36-41, 2021.
Article in English | WPRIM | ID: wpr-880988

ABSTRACT

OBJECTIVE@#Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019 (COVID-19). Tanreqing Capsule (TRQC) was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical Center. This study aimed to investigate the clinical efficacy of TRQC in the treatment of COVID-19.@*METHODS@#A retrospective cohort study was conducted on 82 patients who had laboratory-confirmed mild and moderate COVID-19; patients were treated with TRQC in one designated hospital. The treatment and control groups consisted of 25 and 57 cases, respectively. The treatment group was given TRQC orally three times a day, three pills each time, in addition to conventional Western medicine treatments which were also administered to the control group. The clinical efficacy indicators, such as the negative conversion time of pharyngeal swab nucleic acid, the negative conversion time of fecal nucleic acid, the duration of negative conversion of pharyngeal-fecal nucleic acid, and the improvement in the level of immune indicators such as T-cell subsets (CD3, CD4 and CD45) were monitored.@*RESULTS@#COVID-19 patients in the treatment group, compared to the control group, had a shorter negative conversion time of fecal nucleic acid (4 vs. 9 days, P = 0.047) and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid (0 vs. 2 days, P = 0.042). The level of CD3@*CONCLUSION@#Significant reductions in the negative conversion time of fecal nucleic acid and the duration of negative conversion of pharyngeal-fecal nucleic acid were identified in the treatment group as compared to the control group, illustrating the potential therapeutic benefits of using TRQC as a complement to conventional medicine in patients with mild and moderate COVID-19. The underlying mechanism may be related to the improved levels of the immune indicator CD3


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Antiviral Agents/therapeutic use , COVID-19/pathology , Capsules , DNA, Viral/analysis , Drugs, Chinese Herbal/therapeutic use , Feces/virology , Length of Stay , Lymphocyte Count , Medicine, Chinese Traditional/methods , Retrospective Studies , SARS-CoV-2/genetics , Severity of Illness Index , Treatment Outcome
15.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 13: 1205-1210, jan.-dez. 2021. ilus
Article in English, Portuguese | BDENF, LILACS | ID: biblio-1253510

ABSTRACT

Objective: To synthesize the evidence in the literature on the applicability of the Ryodoraku system in the energy diagnosis based on the precepts of Traditional Chinese Medicine. Method: integrative review, carried out by independent reviewers in databases. Results: we found 324 studies. After exclusion, eight were analyzed, with a predominance of descriptive studies. There was agreement about the 24 points selected for the application of Ryodoraku; however, there is disagreement as to their location. Conclusions: Ryodoraku still does not present consistent evidence on its use, limiting the evaluation of its applicability


Objetivo: Sintetizar as evidências disponíveis na literatura sobre a aplicabilidade do sistema Ryodoraku no diagnóstico energético baseado nos preceitos da Medicina Tradicional Chinesa. Método: revisão integrativa, realizada por revisores independentes em bases de dados. Resultados: encontrou-se 324 estudos. Após exclusões, oito foram analisados, com predomínio de estudos descritivos. Houve concordância acerca dos 24 pontos selecionados para a aplicação do Ryodoraku; entretanto, há divergência quanto à localização dos mesmos. Conclusões: o Ryodoraku ainda não apresenta evidências consistentes sobre sua utilização, limitando a avaliação de sua aplicabilidade.


Objetivo: Sintetizar las evidencias de la literatura sobre la aplicabilidad del sistema Ryodoraku en el diagnóstico energético basado en los preceptos de la Medicina Tradicional China. Método: revisión integrativa, realizada por revisores independientes en bases de datos. Resultados: se han encontrado 324 estudios. Después de exclusiones, ocho fueron analizados, con predominio de estudios descriptivos. Hubo concordancia sobre los 24 puntos seleccionados para la aplicación del Ryodoraku; sin embargo, hay divergencia en cuanto a la localización de los mismos. Conclusión: el Ryodoraku todavía no presenta evidencias consistentes sobre su utilización, limitando la evaluación de su aplicabilidad


Subject(s)
Humans , Male , Female , Acupuncture Points/classification , Electrodiagnosis/methods , Medicine, Chinese Traditional/methods , Diagnosis, Differential , Electric Conductivity/therapeutic use
16.
Brasília; Fiocruz Brasília;Instituto de Saúde de São Paulo; ago. 3, 2020. 22 p.
Non-conventional in Portuguese | MTYCI, PIE, ColecionaSUS, LILACS | ID: biblio-1118200

ABSTRACT

As práticas corporais da Medicina Tradicional Chinesa (MTC) envolvem movimento ou manipulação corporal, atitude mental e respiração com intuito de equilibrar o Qi ou energia vital. As práticas da MTC são recomendadas para promoção, manutenção e recuperação da saúde, bem como prevenção de agravos e doenças. As práticas corporais da MTC, no Brasil, incluem acupuntura,lian gong, chi gong (qigong,chi kung); tui-naetai chi chuan. Estas práticas foram incorporadas no SUS mediante Portaria no 971, de 03 de maio de 2006. Qual é a eficácia/efetividade e a segurança das práticas corporais da Medicina Tradicional Chinesa (MTC), exceto acupuntura, no tratamento da obesidade em adultos e/ou idosos? As buscas foram realizadas inicialmente por revisões sistemáticas, mas nenhuma atendeu aos critérios de elegibilidade. Novas buscas foram realizadas em seis bases de dados sem restrição de ano de publicação, para identificar ensaios clínicos randomizados(ECR). Desta forma, foram incluídos ensaios clínicos randomizados em inglês, português e espanhol que avaliaram os efeitos das práticas MTC no tratamento de obesidade na população adulta e idosa. A avaliação da qualidade metodológica foi realizada por meio da ferramenta de risco de viés da Cochrane, feita por uma pesquisadora e revisada por outra. Nesta revisão rápida, produzida em três dias, foram utilizados atalhos metodológicos, de maneira que apenas o processo de seleção foi realizado em duplicidade e de forma independente. A acupuntura, embora faça parte das práticas da MTC, não foi incluída porque está sendo analisada separadamente em outras revisões realizadas por esta mesma equipe. De 1.435 publicações recuperadas nas bases de dados, foram incluídos três ensaios clínicos randomizados que atenderam aos critérios de elegibilidade. A avaliação metodológica dos ECR demonstrou risco de viés, de forma que os resultados devem ser interpretados com cautela. Os estudos mostraram não haver diferença nos resultados entre Taichi e a maioria dos comparadores, com relação aos desfechos IMC, circunferência da cintura, peso corporal, massa corporal, gordura corporal e sensação de fome. O único estudo sobre Qigong não apresentou resultados favoráveis quanto a sua eficácia na redução do peso corporal. Um estudo relatou não ter identificado eventos adversos com a prática de Taichi. Embora existam alguns resultados favoráveis a prática de Taichi, é pequena a evidência de eficácia e segurança da prática no tratamento da obesidade em adultos e idosos. Devido à escassez de evidências não é possível afirmar os reais benefícios do uso dessas tecnologias para o tratamento da obesidade.


Subject(s)
Humans , Adult , Middle Aged , Aged , Treatment Outcome , Tai Ji/methods , Qigong/methods , Obesity Management , Complementary Therapies/methods , Medicine, Chinese Traditional/methods
17.
Brasília; Fiocruz Brasília;Instituto de Saúde de São Paulo; ago. 4, 2020. 13 p.
Non-conventional in Portuguese | MTYCI, PIE, ColecionaSUS, LILACS | ID: biblio-1118201

ABSTRACT

As práticas corporais da Medicina Tradicional Chinesa (MTC) envolvem movimento ou manipulação corporal, atitude mental e respiração com intuito de equilibrar a energia vital-Qi. As práticas da MTC são recomendadas para promoção, manutenção e recuperação da saúde, bem como prevenção de agravos e doenças. As práticas corporais da MTC, no Brasil, incluem acupuntura, lian gong, chi gong(qigong,chi kung);tui-na e tai chi chuan. Estas práticas foram incorporadas no SUS mediante Portaria no 971,de 03 de maio de 2006.PerguntaQualéa eficácia/efetividade e a segurança das práticas corporais da Medicina Tradicional Chinesa(MTC), exceto acupuntura, na cessação do tabagismo em adultos e/ou idosos? As buscas por revisão sistemática foram realizadas em cinco bases de dados sem restrição de ano de publicação, publicados em inglês, português e espanhol. A busca foi por estudos que avaliassem o efeito das práticas corporais na cessação do tabagismo em adultos e idosos. Uma busca adicional por ensaios clínicos randomizados foi realizada em seis bases de dados, respeitando os mesmos critérios de elegibilidade. A acupuntura, embora faça parte das práticas da MTC, não foi incluída porque estás endo analisada separadamente em outras revisões realizadas por esta mesma equipe. De 111 revisões sistemáticas e 1.525 ensaios clínicos recuperados nas bases de dados, nenhum estudo atendeu aos critérios de elegibilidade. Devido à falta de evidências não é possível tecer considerações sobre a eficácia e segurança das práticas de MTC no controle do tabagismo na população adulta.


Subject(s)
Humans , Adult , Aged , Tobacco Use Disorder/prevention & control , Smoking Cessation , Medicine, Chinese Traditional/methods , Treatment Outcome
18.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 941-951, 2020.
Article in English | WPRIM | ID: wpr-881040

ABSTRACT

As a representative drug for the treatment of severe community-acquired pneumonia and sepsis, Xuebijing (XBJ) injection is also one of the recommended drugs for the prevention and treatment of coronavirus disease 2019 (COVID-19), but its treatment mechanism for COVID-19 is still unclear. Therefore, this study aims to explore the potential mechanism of XBJ injection in the treatment of COVID-19 employing network pharmacology and molecular docking methods. The corresponding target genes of 45 main active ingredients in XBJ injection and COVID-19 were obtained by using multiple database retrieval and literature mining. 102 overlapping targets of them were screened as the core targets for analysis. Then built the PPI network, TCM-compound-target-disease, and disease-target-pathway networks with the help of Cytoscape 3.6.1 software. After that, utilized DAVID to perform gene ontology (GO) function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to predict the action mechanism of overlapping targets. Finally, by applying molecular docking technology, all compounds were docked with COVID-19 3 CL protease(3CLpro), spike protein (S protein), and angiotensin-converting enzyme II (ACE2). The results indicated that quercetin, luteolin, apigenin and other compounds in XBJ injection could affect TNF, MAPK1, IL6 and other overlapping targets. Meanwhile, anhydrosafflor yellow B (AHSYB), salvianolic acid B (SAB), and rutin could combine with COVID-19 crucial proteins, and then played the role of anti-inflammatory, antiviral and immune response to treat COVID-19. This study revealed the multiple active components, multiple targets, and multiple pathways of XBJ injection in the treatment of COVID-19, which provided a new perspective for the study of the mechanism of traditional Chinese medicine (TCM) in the treatment of COVID-19.


Subject(s)
Humans , Angiotensin-Converting Enzyme 2/metabolism , Biological Availability , COVID-19/virology , Coronavirus 3C Proteases/metabolism , Drugs, Chinese Herbal/therapeutic use , Medicine, Chinese Traditional/methods , Molecular Docking Simulation/methods , Protein Interaction Mapping/methods , SARS-CoV-2/physiology , Signal Transduction/drug effects , Spike Glycoprotein, Coronavirus/metabolism
19.
Rio de Janeiro; s.n; 2019. 132 p. ilus, tab, graf.
Thesis in Portuguese | LILACS, BDENF | ID: biblio-1418410

ABSTRACT

Dentre as doenças raras, a Fibrose Cística (FC) é a mais frequente no Brasil e é reconhecida como a mais importante doença hereditária. Diferentes estudos apontam para a presença de dor e ansiedade neste grupo de pacientes e correlacionam com pior adesão, menor função pulmonar e menor qualidade de vida. A assistência do enfermeiro ao paciente e suas famílias deve ser estabelecida na perspectiva do cuidado integral, e primar pela busca de resultados favoráveis dos aspectos físicos e biopsicossociais. O uso da Acupuntura associado ao tratamento convencional, pode agir neste intento. Entende-se a acupuntura realizada pelo enfermeiro como uma tecnologia aplicada ao cuidado de enfermagem que se opera em atos e que pode ter seu processo de avaliação norteado através das respostas aos diagnósticos de enfermagem, defendida como possibilidade terapêutica. Objetivo geral: avaliar as respostas dos Diagnósticos de Enfermagem Dor e Ansiedade à intervenção com acupuntura associada ao tratamento convencional de adolescentes com Fibrose Cística. Objetivos específicos: analisar a evolução dos Diagnósticos de Enfermagem, Dor e Ansiedade, identificados em adolescentes com Fibrose Cística durante tratamento com acupuntura; avaliar a evolução dos parâmetros de acompanhamento clínico de padrão respiratório observados em adolescentes com Fibrose Cística durante o tratamento; e relacionar o diagnóstico energético à luz da Medicina Tradicional Chinesa com os Diagnósticos de Enfermagem sob análise nesses adolescentes. Método. Estudo quase-experimental, comparativo, do tipo antes-depois, com abordagem quantitativa, realizado em ambulatório especializado de Pediatria, com 13 adolescentes com diagnóstico de FC, após aplicação de cálculo de amostra aleatória simples, poder do teste (1-ß) de 80% e nível de significância (α) de 5%. Foram utilizados instrumentos já validados para a captação dos dados: consulta de enfermagem; escala visual analógica da dor; escala hospitalar de ansiedade e depressão; padrão respiratório e prontuário dos participantes. As medições foram registradas em uma planilha de Excel®. Para o estímulo dos pontos após estabelecido o diagnóstico, foi utilizada a técnica de laser-acupuntura com equipamento infravermelho, duração de aproximadamente 30 (trinta) minutos cada entre o preparo do participante e o procedimento. O tratamento foi individualizado, de intervenção única. Para realização das análises foi utilizado pacote estatístico Action, disposto sob a plataforma do R. A descrição dos dados foi apresentada na forma de frequência observada, porcentagem, valor mínimo e máximo, medidas de tendência central e de variabilidade. Resultados. Dos participantes, 38,5 % possuem baixo peso e 23% na faixa considerada pré-obesidade; 30,8% possuem 1o ano do ensino médio; 46,1% são evangélicos, com renda familiar inferior a dois salários mínimos. No referente às doenças associadas, um participante (7,7%) relatou diabetes e um (7,7%) doença celíaca e epilepsia. O tempo de diagnóstico variou de menos de um ano a doze anos de idade. O DE 'falta de adesão' foi identificado em 100% dos participantes em algum momento da avaliação, seguido da ansiedade (84,6%), campo energético perturbado (69,3%), dor (69,3%), atividade de recreação deficiente (61,5%) e insônia (53,8%). Os resultados pré e pós intervenção revelaram que, para a escala de ansiedade, o escore após a realização da LA foi menor em média (4.5; DP ± 2.8) do que antes da realização da mesma (6.8; DP ± 3.5); a frequência respiratória foi menor em mediana (20 irpm) após a realização da LA do que antes de sua realização da mesma (22 irpm); a média da frequência cardíaca reduziu (75.69 bpm; DP ± 10.20 irpm) após a aplicação da LA. Já a saturação do O 2 aumentou em média (97.77; DP ± 1.42) após a aplicação e a dor se manteve constante antes da aplicação e nos 3 momentos posteriores; apenas 15,4% participantes referiram dor no momento da avaliação que, apesar de sua relevância clínica, foi um n inexpressivo para avalição estatística.


Subject(s)
Humans , Male , Female , Adolescent , Nursing Diagnosis , Cystic Fibrosis/diagnosis , Acupuncture , Medicine, Chinese Traditional , Anxiety/diagnosis , Pain/diagnosis , Pediatric Nursing , Quality of Life , Respiration , Critical Pathways , Acupuncture/methods , Depression/psychology , Treatment Adherence and Compliance , Medicine, Chinese Traditional/methods
20.
Rev. cuba. enferm ; 34(3): e1395, jul.-set. 2018. tab
Article in Spanish | LILACS, BDENF, CUMED | ID: biblio-1099051

ABSTRACT

RESUMEN Introducción: La cefalea es uno de los trastornos más comunes del sistema nervioso en todo el mundo, frecuentemente es signo de otras enfermedades. Mientras la medicina occidental trata los síntomas con medicamentos, los médicos alternativos tratan la causa con acupuntura para proporcionar alivio duradero. Objetivo: Evaluar la efectividad de la acupuntura con microsistema de cara como tratamiento de pacientes con cefalea migrañosa. Métodos: Estudio cuasiexperimental de tipo casos-controles con 100 pacientes que asistieron a la Clínica del Dolor del Hospital "Dr. Ambrosio Grillo Portuondo", en Santiago de Cuba, con diagnóstico de cefalea migrañosa, desde enero de 2014 a noviembre de 2015. Al grupo estudio se aplicó acupuntura con microsistema de cara; al grupo control, medicamentos. La información se obtuvo de las historias clínicas, el dolor se valoró con la escala analógica visual del dolor. Se aplicó Ji cuadrado de homogeneidad para la identificar diferencias significativas entre las proporciones de efectividad de uno y otro tratamiento, con un nivel de significación (α;= 0,05). Resultados: Predominó el sexo femenino (70,00 por ciento), el grupo etareo 18-39 años, de ellos 40 en el grupo estudio (80,00 por ciento), 43 en el control (86,00 por ciento). En el grupo estudio el 82,00 por ciento de los pacientes quedó sin dolor desde la primera sesión del tratamiento, el 18,00 por ciento con dolor disminuido. Al final del tratamiento el 98,00 por ciento del grupo estudio quedó sin dolor contra el 96,00 por ciento del grupo control. Conclusión: La acupuntura con microsistema de cara es un método alternativo efectivo en el tratamiento de la cefalea migrañosa(AU)


ABSTRACT Introduction: Headache is one of the most common nervous system disorders worldwide. It is frequently a sign of other diseases. While Western medicine treats symptoms with medications, alternative practitioners treat the cause with acupuncture to provide long-lasting relief. Objective: To evaluate the effectiveness of acupuncture with a facial microsystem as a treatment for patients with migraine headache. Methods: Quasiexperimental case-control study with 100 patients who attended the Pain Clinic at Dr. Ambrosio Grillo Portuondo Hospital in Santiago de Cuba, with a diagnosis of migraine headache, from January 2014 to November 2015. The study group was applied acupuncture with a facial microsystem. The control group was treated with medicines. The information was obtained from the medical records. The pain was assessed using the Visual Analogue Scale. Chi-square test of homogeneity was applied in order to identify significant differences between the proportions of effectiveness of one treatment and another, with a level of significance α =0.05. Results: There was predominance of the female sex (70.00 percent), age group 18-39 years, among them 40 in the study group (80.00 percent) and 43 in the control group (86.00 percent). In the study group, 82.00 percent of patients remained without pain from the first session of treatment and 18.00 percent with pain decreased. At the end of the treatment, 98.00 percent of the study group remained without pain in opposition to 96.00 percent of the control group. Conclusion: Acupuncture with a facial microsystem is an effective alternative method in the treatment of migraine headache(AU)


Subject(s)
Humans , Female , Adult , Acupuncture Therapy/methods , Pain Clinics , Evaluation of the Efficacy-Effectiveness of Interventions , Migraine Disorders/diagnosis , Acupuncture Analgesia/adverse effects , Treatment Outcome , Medicine, Chinese Traditional/methods
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