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1.
Arq. bras. med. vet. zootec. (Online) ; 72(3): 794-798, May-June, 2020. ilus
Article in Portuguese | ID: biblio-1129180

ABSTRACT

Meningiomas são os principais tumores primários do sistema nervoso central (SNC) que afetam cães e gatos. Na maioria dos casos, são neoplasias benignas, geralmente expansivas, causando compressão do SNC, e raramente fazem metástase para outros órgãos. O presente trabalho tem como objetivo relatar a ocorrência de um meningioma microcístico com metástase pulmonar em um canino de 11 anos de idade, com sinais clínicos de andar cambaleante, compressão da cabeça contra objetos, agitação, salivação e agressividade. Na necropsia, foram observadas, no encéfalo, massas bem delimitadas pardo-avermelhadas, firmes, de aspecto granular, localizadas no córtex parietal e nos núcleos da base. Inúmeras micronodulações de aspecto semelhante foram observadas no pulmão. Histologicamente observaram-se nódulos formados por células neoplásicas fusiformes, com núcleos grandes e alongados e nucléolos evidentes, dispostas de forma frouxa, formando vacúolos e microcistos. À imuno-histoquímica, o meningioma apresentou marcação fortemente positiva para citoqueratina e negativa para vimentina. Por meio da histopatologia e da imuno-histoquímica, foi possível estabelecer a classificação histológica de meningioma microcístico, bem como diferenciá-lo de outras doenças que cursam com sinais nervosos.(AU)


Meningiomas are the main tumors of the central nervous system (CNS) affecting dogs and cats. In most of the cases they are benign neoplasms, usually expansive, causing compression of the CNS and rarely metastasize to other organs. We describe the occurrence of a microcystic meningioma with pulmonary metastasis in an 11 - year - old canine with clinical signs of staggering gait, head compression against objects, agitation, salivation and aggressiveness. At necropsy, well-defined, firm, granular-looking masses located in the parietal cortex and nuclei of the base were observed in the encephalon. Numerous micronodulations of similar appearance were observed in the lung. Histologically, nodules formed by spindle neoplastic cells with large, elongated nuclei and evident nuclei were loosely arranged, forming vacuoles and microcysts. Immunohistochemistry were strongly positive for cytokeratin and negative for vimentin. Through the histopathology and immunohistochemistry, it was possible to establish the histological classification of microcystic meningioma, as well as to differentiate from other diseases that present with nervous signals.(AU)


Subject(s)
Animals , Dogs , Lung/pathology , Meningioma/complications , Meningioma/veterinary , Neoplasm Metastasis , Immunohistochemistry/veterinary , Central Nervous System Neoplasms/veterinary , Lung Neoplasms/veterinary
2.
Rev. medica electron ; 41(6): 1367-1381, oct.-dic. 2019. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1094136

ABSTRACT

RESUMEN Introducción: los meningiomas constituyen la segunda causa de tumores cerebrales primarios, en el adulto. Representan hasta el 32 % del total de los mismos. Objetivo: describir el comportamiento del meningioma intracraneal en los pacientes investigados. Materiales y métodos: se realizó un estudio analítico, descriptivo, retrospectivo a los pacientes neurointervenidos con meningioma intracraneal, en el Servicio de Neurocirugía del Hospital Docente Universitario "Comandante Faustino Pérez Hernández", de la provincia Matanzas. En el período comprendido entre el 1ero de enero de 2017 al 1ero de enero del 2019. Los 15 pacientes intervenidos conformaron el universo de estudio. Resultados: la media poblacional fue de 55 años. Predominó el sexo femenino en un 73,3 %. La cefalea fue la manifestación clínica más frecuente, igualmente, que los meningiomas de la convexidad cerebral. En cuanto a la topografía, la media del tamaño de la lesión fue de 4,4 cm. La variedad meningotelial (40 %) fue la que predominó. El grado II de resección fue el que más se empleó. El edema cerebral postquirúrgico predominó en un 26,6 %. La puntuación de la escala de Karnofsky al egreso fue superior que al ingreso. Conclusiones: cuanto más precoz se realice el diagnóstico clínico y tratamiento quirúrgico en los pacientes portadores de meningioma, mejor será su calidad de vida al egreso (AU).


ABSTRACT Introduction: meningiomas are the second cause of primary brain tumors in adults, representing up to 32 % of the total. Objective: to describe the behavior of intracranial meningioma in the studied patients. Materials and methods: a retrospective, descriptive, analytical study was conducted on neurosurgery patients with intracranial meningioma in the Neurosurgery service of the University Teaching Hospital "Comandante Faustino Pérez Hernández" of the province of Matanzas, in the period from January 1st 2017 to January 1st, 2019. The 15 patients undergoing neurosurgery were the study universe. Results: the population mean was 55 years; female sex prevailed (73.3 %). Headache was the most frequent clinical manifestation as well as meningiomas of cerebral convexity in terms of topography. The average lesion size was 4.4 cm; the meningothelial variety (40 %) was the most commonly found; grade II resection was the most used one. Post-surgical cerebral edema (26.6%) predominated. Karnofsky scale score at discharge was higher than at admission. Conclusions: the earlier the clinical diagnosis and surgical treatment are performed in patients with meningioma the better will be their quality of life at discharge (AU).


Subject(s)
Humans , Adult , Middle Aged , Aged , Brain Neoplasms/epidemiology , Meningioma/epidemiology , Quality of Life , Analytical Methods , Epidemiology, Descriptive , Retrospective Studies , Meningioma/surgery , Meningioma/complications , Meningioma/diagnosis , Neurosurgery
6.
Rev. chil. neurocir ; 38(2): 99-104, dic. 2012. ilus, tab
Article in Spanish | LILACS | ID: lil-716543

ABSTRACT

Los meningiomas clinoideos son tumores benignos originados en la leptomeninges que rodea el proceso clinoideo anterior, representando el 17 por ciento de los basales. Con el objetivo de caracterizarlos se estudiaron los pacientes operados en el Servicio de Neurocirugía del Hospital Hermanos Ameijeiras (2000 al 2010). La serie estuvo integrada por 10 pacientes, 9 mujeres y un hombre, la edad promedio fue de 49,8 años, clínicamente caracterizados por cefalea (10 pacientes) y déficit de la agudeza visual (9 pacientes). A todos se les practicó un abordaje frontotemporal-orbitozigomático (FTOZ) alcanzándose 7 resecciones totales y 3 subtotales, 3 pacientes sufrieron complicaciones, al alta ocho de los diez operados egresaron en excelente estado, no tuvimos recidiva ni recrecimiento tumoral en los casos con resecciones parciales y al año de seguimiento la calidad de vida según la escala de Karnofsky fue superior o igual a 80 puntos en todos los casos. Concluimos que los meningiomas clinoideos por su asiento en el centro de la base craneal relacionados anatómicamente con estructuras neurovasculares críticas y por las grandes dimensiones que alcanzan en el momento de su diagnóstico, representan un desafío en la práctica neuroquirúrgica, comportándose en nuestra serie más frecuentes entre las mujeres con la cefalea y el déficit visual monocular como síntomas principales. Las técnicas de base de cráneo y en nuestras manos la craneotomía FTOZ complementadas con osteotomías basales de diferentes grados, han demostrado ser una alternativa eficaz para mejorar la suficiencia de la resección tumoral con mínima morbilidad, ausencia de recurrencias y mortalidad.


Clinoidal meningeomas are benign tumors originated in the liptomeningeo surrounding the anterior clinoidal process representing 17 percent of basal tumors. With the objective to characterize it, studied were patients operated in the neurosurgical service of Hermanos Ameijeiras hospital from 2000 to 2010.The series were composed of 10 patients, 9 female and a male, the mean age was 49.8 years and were clinically characterized with headache (10 patients) and visual deficit (9 patients). To all were practiced a frontotemporal orbitozygomatic approach (FTOZ) reaching 7 total and 3 subtotal removal,3 patients suffered complications, 8 out of 10 patients operated were discharged in good condition. There was no recurrence after total removal and after a year of fellow up, the life quality following Karnofsky scale was superior o equal to 80 points in all the cases. In conclusion Clinoidal meningeomas due to its placement in the cranial base with anatomical relations with critical neurovascular structures and also the great dimension to reach in the moment of its diagnosis represents a challenge to neurosurgical practice. It comports in our series with more frequency within females presenting headache and mono ocular visual defect as the principal symptoms. Craneal base techniques and in our case frontotemporal-orbitozygomatic craniotomy complimented with basal osteotomy of different grades, had demonstrated to be an efficient alternative to better the technique of total removal with less mobility, zero recurrence and mortality.


Subject(s)
Humans , Male , Adult , Female , Middle Aged , Skull Base/surgery , Craniotomy , Diagnostic Imaging , Meningioma/surgery , Meningioma/complications , Meningioma/diagnosis , Meningioma/mortality , Meningeal Neoplasms/surgery , Osteotomy , Cuba , Epidemiology, Descriptive , Retrospective Studies
7.
Article in Korean | WPRIM | ID: wpr-227513

ABSTRACT

Mantle cell lymphoma (MCL) is an uncommon type of gastrointestinal lymphoma. MCL is a distinct subtype of B-cell non-Hodgkin lymphomas. The major subtype of MCL is characterized by the presence of multiple lymphomatous polyposis (MLP), in which multiple polyps are observed along the gastrointestinal tract. The malignant cells express pan B-cell marker and the T-cell marker cluster of differentiation 5. The chromosomal translocation t(11;14)(q13;q32) that causes cyclin D1 overexpression is commonly observed on the cytogenetic analysis of MCL. Survival improvement has recently been achieved for patient with MCL by the successful introduction of monoclonal antibodies and dose-intensified approaches for treatment, including autologous stem cell transplantation strategies. Some reports suggest that there is an increased incidence of second malignancies in patients with MCL or lymphoma. We report a case of MCL involving the colon; the patient was a 60-year-old man who complained of low abdominal discomfort during defecation. During the workup, a meningioma was unexpectedly discovered. On analysis, the tumor was found to be a t(11;14)-negative and non-MLP-type MCL.


Subject(s)
Chromosomes, Human, Pair 11 , Chromosomes, Human, Pair 14 , Cyclin D1/metabolism , Humans , Lymphoma, Mantle-Cell/diagnosis , Magnetic Resonance Imaging , Male , Meningeal Neoplasms/complications , Meningioma/complications , Middle Aged , Positron-Emission Tomography , Translocation, Genetic
8.
Article in English | WPRIM | ID: wpr-119893

ABSTRACT

Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hurthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.


Subject(s)
Aged , Base Sequence , Brain/diagnostic imaging , Female , Humans , Hyperaldosteronism/complications , Hyperparathyroidism, Primary/diagnosis , Loss of Heterozygosity , Magnetic Resonance Imaging , Meningeal Neoplasms/complications , Meningioma/complications , Mutation , Parathyroid Glands/pathology , Proto-Oncogene Proteins/genetics , Sequence Analysis, DNA , Thyroid Neoplasms/complications , Tomography, X-Ray Computed
10.
Rev. chil. neurocir ; 37: 23-28, jul. 2011. ilus, tab
Article in English | LILACS | ID: lil-708072

ABSTRACT

Background: Intraventricular meningiomas are rare tumors and pose clinical, radiological, and surgical challenges. Individualized approach helps to establish successful results. Methods: Thirteen patients underwent craniotomy for intraventricular meningioma resection from 1999 to 2007. The mean age was 45 years (23-64), time of presentation between 25 days to three years. There were ten females and three males. Headaches and seizures were the most frequent initial presentations. Tumors were located in the ventricular trigone in 11 patients and in the temporal horn in two. Results: There were seven posterior temporal and seven parieto-occipital transcortical craniotomies, one patient was operated two times. Resection grade was Simpson I in nine patients, Simpson II in four, and Simpson III in one case. Surgical mortality was zero. There were six complications. Two patients had ventriculitis, one patient had hematoma of the surgical bed, one patient had severe post-operative cognitive impairment and one presented with progression of motor deficits. In two patients, there was transient memory disturbance after the parieto-occipital approach. Conclusion: Correct understanding of microsurgical anatomy cooperates for further success in operation of intraventricular meningiomas. Pre-operative embolization is helpful to reduce bleeding when a suitable tumor feeder can be accessed with no reflux. Dynamic changes in the shape of the ventricular cavity have to be considered when planning the most suitable route. Rigorous hemostasis and ventricular drainage are important points to avoid main complication.


Subject(s)
Humans , Adult , Young Adult , Middle Aged , Cerebral Ventricle Neoplasms , Embolization, Therapeutic , Meningioma/surgery , Meningioma/complications , Meningioma/diagnosis , Meningioma/mortality , Meningioma/pathology , Retrospective Studies
11.
Arq. bras. neurocir ; 30(2)jun. 2011. ilus
Article in Portuguese | LILACS | ID: lil-604905

ABSTRACT

Relatamos o caso de uma mulher de 65 anos de idade, com queixa de cefaleia, portadora de uma lesão expansiva em região posterior da tenda do cerebelo, implantado na tórcula, sugestivo de meningioma pelos exames de imagens, foi submetida ao tratamento neurocirúrgico para ressecção. Ao exame anatomopatológico, foi sugerido diagnóstico de doença de Rosai-Dorfman, confirmado pela imunohistoquímica. Trata-se de uma rara linfadenopatia proliferativa histiocítica, de comportamento benigno, com acometimento mais frequente da cadeia linfonodal cervical e outros sítios extranodais, sendo extremamente rara sua localização no sistema nervoso central, principalmente na fossa posterior, sem acometimento de outras estruturas anatômicas.


We report the case of a woman 65 years old, complaining of headache, carries a lesion in the posterior region of the tent of the cerebellum, implanted in torcula, suggestive of meningioma by imaging tests, was subjected to neurosurgical procedures for resection. When pathological examination suggested a diagnosis of Rosai-Dorfman disease, confirmed by immunohistochemistry. It is a rare proliferative histiocytic lymphadenopathy in benign behavior, with more frequent involvement of cervical lymph node and other extranodal sites, its location is extremely rare in the central nervous system, especially in the posterior fossa without involvement of other anatomical structures.


Subject(s)
Humans , Female , Aged , Histiocytosis, Sinus , Meningioma/complications
12.
Salud(i)ciencia (Impresa) ; 18(3): 276-279, mayo 2011. ilus
Article in Spanish | LILACS | ID: lil-616749

ABSTRACT

Caso único de meningioma ectópico en un varón de 46 años, que se supone el primer informe de tumor primario ectópico multifocal en distintas regiones anatómicas del cuerpo humano. Se discuten los aspectos clínicos e histológicos de estas lesiones.


Subject(s)
Humans , Male , Adult , Meningioma/complications , Meningioma/diagnosis , Meningioma/physiopathology , Thoracic Injuries/diagnosis , Thoracic Injuries/therapy , Histological Techniques
13.
MEAJO-Middle East African Journal of Ophthalmology. 2011; 18 (3): 256-258
in English | IMEMR | ID: emr-130068

ABSTRACT

Ophthalmic vein thrombosis is an extremely rare entity. We present a case of middle-aged female who presented with proptosis. Contrast-enhanced computed tomography and magnetic resonance imaging showed cavernous sinus meningioma with ipsilateral superior and inferior vein thrombosis. A brief review of the vascular involvement of the meningioma and ophthalmic vein thrombosis is presented along with the case


Subject(s)
Humans , Female , Middle Aged , Orbital Diseases/etiology , Orbital Diseases/etiology , Veins , Eye/blood supply , Cavernous Sinus/pathology , Meningioma/complications , Meningioma/diagnosis , Magnetic Resonance Imaging
15.
Arq. neuropsiquiatr ; 68(3): 346-349, June 2010. ilus, graf
Article in English | LILACS | ID: lil-550263

ABSTRACT

Occurrence of peritumoral brain edema (PBE) in meningiomas has been associated with several factors in recent years, although its pathophysiological mechanism has not yet been fully elucidated. The aim of this study was to analyze the correlation between the presence / degree of PBE and factors such as gender, age, size and histological subtype of tumor. We analyzed the MRI images of 74 patients operated on Hospital Beneficência Portuguesa de Porto Alegre for the presence / degree of PBE and data was statistically correlated with the parameters of the patient. PBE was present in 70.1 percent of patients. Tumors with higher volume had more PBE. Tumors of the olfactory groove showed more PBE than sphenoid wing and parassagittal tumors. Transitional subtype showed more PBE than fibroblastic and meningothelial subtypes.


A presença de edema cerebral peritumoral (ECP) em meningiomas tem sido associada a diversos fatores nos últimos anos, embora o seu mecanismo fisiopatológico ainda não tenha sido inteiramente elucidado. O objetivo desse estudo foi analisar a correlação entre a presença/grau de ECP e fatores como sexo, idade, volume e subtipo histológico do tumor. Foram analisadas imagens de RM de 74 pacientes operados no Hospital Beneficência Portuguesa de Porto Alegre quanto à presença/grau de ECP e os dados correlacionados estatisticamente com os parâmetros do paciente. ECP estava presente em 70,1 por cento dos pacientes. Tumores com maior volume apresentaram mais ECP. Tumores da goteira olfatória apresentaram mais ECP que os da asa do esfenóide e que os parassagitais. Meningiomas transicionais apresentaram mais ECP que os fibroblásticos e que os meningoteliais.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Brain Edema/pathology , Meningeal Neoplasms/pathology , Meningioma/pathology , Age Factors , Brain Edema/etiology , Magnetic Resonance Imaging , Meningeal Neoplasms/complications , Meningioma/complications , Retrospective Studies , Severity of Illness Index , Sex Factors , Tumor Burden , Young Adult
17.
Bulletin of Alexandria Faculty of Medicine. 2010; 46 (4): 281-286
in English | IMEMR | ID: emr-110767

ABSTRACT

To study the functional outcome after surgical excision of cortical meningio-angiomatosis [MA] in terms of seizure control and neurological disability. Four patients with MA were diagnosed with refractory epilepsy. All were surgically treated. Four cases of MA were reported three males and one female. Median age at presentation was 19 years [range 9-23 years]. All patients had refractory seizures for 1-18 years with a median of 8 years. Two patients had exclusively simple partial seizures, with secondary generalization; the other two patients had complex partial seizures, with secondary generalization. CT and MRI were done for all patients. The lesion was in the right frontal lobe in one patient, left frontal in one patient, left tempropolar in one patient and right temporal in one patient. After surgical resection, three patients remained seizure free without antiepileptic treatment and the fourth patient became controlled on monotherapy of antiepileptic treatment. No patients had added neurological deficit in the postoperative follow-up period of six months to eight years [mean 4.7 years] MA commonly presents as refractory epilepsy. Although MA occurs infrequently, it is important to establish the correct diagnosis. Surgical excision is usually associated with good functional outcome with the patients either stop the antiepileptic treatment or become controlled on smaller doses


Subject(s)
Humans , Male , Female , Meningioma/complications , Seizures , Follow-Up Studies , Anticonvulsants , Treatment Outcome
18.
Arq. bras. neurocir ; 28(4)dez. 2009. ilus
Article in Portuguese | LILACS | ID: lil-602480

ABSTRACT

Muitos dos pacientes neurológicos procuram auxílio médico devido a sintomas inespecíficos e subjetivos, nem sempre possíveis de diagnóstico claro e imediato. Dentre tais lesões, os tumores de crescimento lento como os meningiomas estão entre os mais encontrados. Pela acomodação cerebral peritumoral, esses tumores podem atingir volumes extremamente grandes com pouco ou nenhum sintoma associado. Relatamos o caso de paciente que estava sob medicação antipsicótica para tratamento de alterações comportamentais, atendido na Santa Casa de Misericórdia de Santos após crise convulsiva e traumatismo cranioencefálico. Durante a avaliação tomográfica foi encontrado volumoso tumor frontal com lise óssea e extensão para gálea e subcutâneo. Foi submetido à craniotomia eletivamente com ressecção completa da lesão de aproximadamente 9 cm e 145 gramas. O paciente recebeu alta no oitavo dia pós-operatório, consciente, orientado e sem sequelas neurológicas. Este relato visa atentar sempre para uma possível lesão ainda não identificada nos casos de pacientes com sintomas inespecíficos neurológicos, devendo a tomografia computadorizada de crânio, procedimento relativamente simples e quase sempre disponível, ser usada para tal fim.


Many patients have neurological symptoms that could not be easily ellucidated. Meningeomas are frequently involved in those cases, because of their slow growth. The surrouding brain to these lesions may be perfect, or with minimal disfunction, difficulting the diagnosis. On this report, we describe a case of a 47 year-old male, on antipsychotic medical therapy due to behavior disturbances, brougth to the emergency room, victim of head injury following seizure. CT scan showed a large frontal brain tumor, extending to subcutaneos. We performed an elective craniotomy and removed the whole lesion (meningioma; 9 cm and 145 gr), whithout neurological complications. The patient was discharged on 8th postoperative day and returned to his normal life.


Subject(s)
Humans , Male , Middle Aged , Meningioma/surgery , Meningioma/complications , Meningioma/diagnosis , Antipsychotic Agents
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