Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 2.295
Filter
1.
Revagog ; 3(3): 88-103, Jul-Sept. 2021.
Article in Spanish | LILACS, LIGCSA | ID: biblio-1344264

ABSTRACT

Describe los planteamientos sobre el beneficio de la terapia de reemplazo hormonal en las mujeres en la menopausia y el riesgo de contraer cáncer de mama con el uso prolongado del mismo.


Subject(s)
Humans , Female , Menopause/drug effects , Hormone Replacement Therapy/adverse effects , Estradiol/adverse effects , Breast Neoplasms/prevention & control , Cardiovascular Diseases/prevention & control , Osteoporosis, Postmenopausal/prevention & control , Hormone Replacement Therapy/classification
2.
Revagog ; 3(3): 104-110, Jul-Sept. 2021.
Article in Spanish | LILACS, LIGCSA | ID: biblio-1344331

ABSTRACT

El climaterio es una etapa fisiológica que permite al médico reconocer tempranamente los riesgos de patologías y la gran oportunidad de revertirlas. Este trabajo examinará la evidencia actual de la terapia hormonal en la prevención primaria de la enfermedad cardiovascular en mujeres, así como la importancia que igualmente tienen la indemnidad de los ovarios, el peso normal, el uso correcto de antibióticos, la preservación de la microbiota intestinal, las dietas antioxidantes, los estilos de vida saludables y el obligatorio abandono del hábito de fumar.


Subject(s)
Humans , Female , Climacteric/physiology , Menopause/physiology , Cardiovascular Diseases/prevention & control , Hormone Replacement Therapy , Heart Disease Risk Factors , Smoking/adverse effects , Andropause/physiology , Estradiol/therapeutic use , Atherosclerosis/prevention & control , Gastrointestinal Microbiome/drug effects , Healthy Lifestyle
3.
Rev. colomb. obstet. ginecol ; 72(2): 162-170, Apr.-June 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1289314

ABSTRACT

RESUMEN Objetivo: Elaborar una aproximación a la prevalencia de los problemas de sueño (PDS) en mujeres climatéricas colombianas durante la pandemia COVID-19. Materiales y Métodos: Estudio transversal que pertenece al proyecto de investigación Calidad de Vida en la Menopausia y Etnias Colombianas bajo condiciones de pandemia [CAVIMEC+COVID STUDY]. Se incluyeron mujeres naturales y residentes en Colombia entre 40 y 59 años, quienes en los primeros cinco días de junio del 2020 participaron de forma anónima y voluntaria, previo consentimiento informado en el diligenciamiento de un formulario alojado en una plataforma virtual. Los PDS fueron identificados con el tercer ítem de Menopause Rating Scale. Se exploraron características sociodemográficas, la presencia y severidad de los PDS y el estado menopáusico. Se hace estadística descriptiva. Resultados: Participaron 984 mujeres, la mediana de edad fue 47,0 [RIC: 42,0-53,5] años. El 84,5% de las participantes eran mestizas, el 13,7% afrodescendientes y 1,7% indígenas. El 39,3% posmenopáusicas. El 70% residían en la región caribe colombiana. Informaron PDS 637 (64,7%) de las participantes y 112 (11,3%) tenían PDS severos. Las posmenopáusicas informaron un 65,1% de PDS, en forma severa el 10,1%, y las premenopáusicas informaron 64,5%, en forma severa el 12,2%. Conclusiones: Los PDS podrían ser un problema frecuente en las mujeres en estado premenopáusico y postmenopáusico. Se debe explorar este problema en la consulta ginecológica para ofrecer soluciones. Se requieren estudios poblacionales que confirmen estas observaciones.


ABSTRACT Objective: To make an approximation to the prevalence of sleep disorders in Colombian menopausal women during the COVID-19 pandemic. Materials and Methods: Cross-sectional study as part of the Quality of Life in Menopause and Colombian Ethnic Groups research project [CAVIMEC+COVID STUDY]. The population consisted of women born and residing in Colombia, 40 to 59 years of age, who signed an informed consent and agreed to participate by completing an online form, freely and anonymously, in the first five days of June 2020. Sleep disorders were identified using the third item on the Menopause Rating Scale. Sociodemographic characteristics, presence and severity of sleep disorders and menopause status were explored. Descriptive statistics are provided. Results: Overall, 984 women aged 47.0 [IQR: 42.0-53.5] years were included: 84.5% mestizo, 13.7% Afro-Colombian, 1.7% indigenous; 39.3% were postmenopausal; 70% lived in the Caribbean region of Colombia. Sleep disorders were reported by 637 women (64.7%), and 112 (11.3%) had severe sleep disorders. Among postmenopausal women, 65.1% reported sleep disorders with 10.1% reporting severe disorders, while 64.5% of premenopausal reported sleep disorders, and 12.2% severe disorders. Conclusions: Sleep disorders could be a frequent problem among premenopausal as well as postmenopausal women in the pandemic time. This issue should be explored during gynecological visits in order to offer solutions. Population studies that confirm these observations are required.


Subject(s)
Humans , Female , Middle Aged , Climacteric , Sleep Disorders, Circadian Rhythm , Menopause , Pandemics
4.
Int. j. med. surg. sci. (Print) ; 8(2): 1-13, jun. 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1284386

ABSTRACT

Introducción: Las enfermedades cardiovasculares (ECV) son la causa de muerte más frecuente en las mujeres en todo el mundo. La deficiencia de estrógenos debido a la menopausia se asocia con un mayor riesgo a padecer esta patología.Objetivo: Analizar los factores de riesgo cardiovascular en mujeres perimenopausicas con al menos un factor de riesgo cardiovascular modificable mayor (diabetes, hipertensión, dislipemia) con edades comprendidas entre los 45 y 60 años de dos servicios de atención primaria urbanos.Metodología: Estudio descriptivo transversal en dos centros de salud de la ciudad de Ourense (Centro de Salud Novoa Santos y Centro de Salud A Ponte). Las variables analizadas fueron: Actividad estrogénica, tratamiento farmacológico, hábito tabáquico, calidad de vida, índice de masa corporal (IMC), colesterol total, lipoproteína de alta densidad (cHDL), lipoproteína de baja densidad (cLDL) y triglicéridos, tensión arterial sistólica (TAS), tensión arterial diastólica (TAD), frecuencia cardíaca (FC). El estudio contó con la aprobación del Comité Ético de Galicia. El análisis de los datos se efectuó a través del software libre R.Resultados: Participaron 316 mujeres, de las cuales el 64,9% eran menopáusicas. La edad media de la muestra fue de 53,35 ± 4,35 años. El valor medio del IMC fue de 28,125 ± 5,54 Kg/m2. Un 27,8% afirmó presentar hábito tabáquico. El 77,2% de las mujeres de la muestra presentaban niveles de colesterol total ≥200 mg/dl. En relación al cLDL, en el 72,6% de la población estudiada era ≥130 mg/dl. Se observó una correlación estadísticamente significativa entre el IMC y los niveles de triglicéridos, cHDL, TAS, TAD y FC.Conclusiones: Las mujeres perimenopáusicas presentaban una elevada prevalencia hábito tabáquico, obesidad y sobrepeso, a pesar de sufrir al menos un factor de riesgo cardiovascular. Por otra parte mostraron una baja calidad de vida tanto en la dimensión física como mental


Introduction: Cardiovascular disease (CVD) is the most common cause of death in women worldwide. Estrogen deficiency due to menopause is associated with an increased risk of this pathology.Objective: To analyze cardiovascular risk factors in perimenopausal women with at least one major modifiable cardiovascular risk factor (diabetes, hypertension, dyslipemia) between the ages of 45 and 60 of two urban primary care services.Methodology: Cross-sectional descriptive study in two health centers in the city of Ourense (Novoa Santos Health Center and A Ponte Health Center). The variables analyzed were: estrogenic activity, pharmacological treatment, smoking habit, quality of life, body mass index (BMI), total cholesterol, high density lipoprotein (cHDL), low-density lipoprotein (cLDL) and triglycerides, systolic blood pressure (TAS), diastolic blood pressure (TAD), heart rate (FC). The study was approved by the Ethics Committee of Galicia. Data analysis was performed through the free R software.Results: 316 women participated, of whom 64.9% were menopausal. The average age of the sample was 53.35 ± 4.35 years. The average BMI value was 28,125 ± 5.54 Kg/m2. 27.8% said they had a smoking habit. 77.2% of the women in the sample had total cholesterol levels ≥200 mg/dL. In relation to the cLDL, in 72.6% of the population studied it was ≥130 mg/dL. A statistically significant correlation was observed between BMI and triglyceride, cHDL, TAS, TAD and FC levels.Conclusion: Perimenopausal women had a high prevalence of smoking habit, obesity and overweight, despite suffering at least one cardiovascular risk factor. On the other hand they showed a low quality of life in both the physical and mental dimensión.


Subject(s)
Humans , Female , Middle Aged , Primary Health Care , Menopause , Body Mass Index , Heart Disease Risk Factors , Quality of Life , Chi-Square Distribution , Cross-Sectional Studies , Risk Assessment , Lipids/analysis
5.
Rev. cuba. endocrinol ; 32(1): e264, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289384

ABSTRACT

Introducción: El síndrome vasomotor constituye la manifestación clínica más frecuente de la transición menopaúsica y a menudo se asocia con cambios en la función endotelial. Objetivo: Determinar la relación entre la intensidad del síndrome vasomotor y la función endotelial en mujeres de edad mediana aparentemente sanas. Método: Estudio descriptivo transversal, en 133 mujeres de 40-59 años sin factores de riesgo cardiovascular. Se excluyeron aquellas mujeres con menopausia quirúrgica, uso previo de terapia hormonal de reemplazo seis meses antes. Se evaluó la función endotelial mediante la prueba de dilatación mediada por el flujo de la arteria braquial, y la intensidad del síndrome vasomotor mediante la escala de Pérez Piñeiro. Las mujeres fueron distribuidas en dos subgrupos: uno con disfunción endotelial y el otro con función endotelial normal. Para identificar la asociación entre variables se utilizó la prueba Kruskal-Wallis y la prueba Chi Cuadrado para evaluar la significación estadística, considerándose significativos los valores de p < 0,05. Resultados: El 63 por ciento de las mujeres presentaron síndrome vasomotor, 29 de intensidad leve, 31 moderado y muy molesto 33 mujeres. Del total de mujeres, 51 tuvieron disfunción endotelial, para un 38,3 por ciento, mostrando un promedio de dilatación dependiente del endotelio de 1,81±1,57 cm. No se encontró asociación significativa entre la intensidad del síndrome vasomotor y la función endotelial p = 0,139. Conclusiones: La intensidad del síndrome vasomotor no se relacionó con la disfunción endotelial en mujeres de edad mediana. Se necesita ampliar la muestra y realizar estudios prospectivos para identificar el daño vascular en ese grupo de mujeres(AU)


Introduction: The vasomotor syndrome is the most frequent clinical manifestation of the menopausal transition and it is often associated with changes in the endothelial function. Objective: Determine the relation among the intensity of the vasomotor syndrome and the endothelial function in apparently healthy middle age women. Methods: Descriptive cross-sectional study in 113 women of 40-59 years without cardiovascular risk factors. There were excluded women with surgical menopause, and use of replacement hormonal therapy six months before. It was assessed the endothelial function through the dilation test and the flow of the brachial artery, and the intensity of the vasomotor syndrome through the scale of Pérez. The women were organized in two groups: one group of women with endothelial dysfunction and the other of women with normal endothelial function. It was used the Kruskal-Wallis test to identify the association among variables and the chi-Square test to assess the statistical significance considering important the values of p < 0.05. Results: 63 percent of the women presented vasomotor syndrome, 29 of them of slight intensity, 31 moderate and 33 women had a very uncomfortable one. Of the total, 51 women presented endothelial dysfunction representing a 38.3 percent and showing an average of dilation dependant of endothelium of 1.81±1.57 cm. There was not found significant association among the intensity of the vasomotor syndrome and the endothelial function p = 0.139. Conclusions: The intensity of the vasomotor syndrome was not related with the endothelial dysfunction in middle age women. It is needed to expand the sample and to implement prospective studies in order to identify the vascular damage in that group of women(AU)


Subject(s)
Humans , Female , Middle Aged , Climacteric/metabolism , Menopause , Heart Disease Risk Factors , Cross-Sectional Studies , Prospective Studies
6.
Evid. actual. práct. ambul ; 24(3): e002106, 2021. tab
Article in Spanish | LILACS, BINACIS, UNISALUD | ID: biblio-1348697

ABSTRACT

A partir del caso de una paciente con trastorno por deseo sexual hipoactivo durante su climaterio y a través del resumen de los resultados de dos revisiones sistemáticas, los autores de este artículo revisan la evidencia sobre la suplementación con andrógenos para el tratamiento de esta condición clínica. Concluyen que su uso sería relativamente seguro a corto plazo, aunque su eficacia no alcanzaría la relevancia clínica y no contamos aún con mayor información sobre la seguridad en el largo plazo. Los autores destacan además que el abordaje de las pacientes con este problema de salud debería ser realizado en forma integral, incluyendo opciones terapéuticas no farmacológicas e informando sobre las incertidumbres todavía presentes. (AU)


Based on the case of a patient with hypoactive sexual desire disorder during her climacteric period and through the summary of the results of two systematic reviews, the authors of this article review the evidence supporting androgen supplementation for the treatment of this clinical condition. They conclude that its use would be relatively safe in the short term, although its efficacy would not reach clinical relevance and no further information on long-term safety is available. The authors also highlight that patients with this health problem should be approached comprehensively, including non-pharmacological therapeutic options and providing information on the uncertainties still present. (AU)


Subject(s)
Humans , Female , Middle Aged , Testosterone/therapeutic use , Climacteric , Sexual Dysfunctions, Psychological/drug therapy , Androgens/therapeutic use , Menopause , Off-Label Use , Systematic Reviews as Topic
7.
Rev. colomb. menopaus ; 27(1): 24-46, 2021.
Article in Spanish | LILACS, COLNAL | ID: biblio-1283533

ABSTRACT

En enero de 2021 la Asociación Colombiana de Menopausia realizó el simposio "Terapia hormonal de la menopausia" contando con la participación de respetados profesores de la especialidad y a cada uno se le asignó un tema para ser revisado y presentado de acuerdo a la evidencia actual. En noviembre del año 2020 el Instituto de Vigilancia de Medicamentos y Alimentos (INVIMA) había lanzado una alerta sobre "Riesgo de desarrollar cáncer de mama en mujeres postmenopáusicas en manejo con terapia de reemplazo hormonal", apoyándose en una decisión del Reino Unido. Dentro de las afirmaciones de INVIMA se encontró que el uso prolongado por más de un año incrementa el riesgo de cáncer de mama sin que sea claro su soporte científico para tal afirmación. El pronunciamiento del Reino Unido se soportó en el estudio "Tipo y momento de la terapia hormonal de la menopausia y el riesgo de cáncer de mama: Meta-análisis de participantes individuales de la evidencia epidemiológica mundial, del Grupo de colaboración sobre factores hormonales en el cáncer de mama, publicado en la revista médica The Lancet el 29 de agosto de 2019. Varias asociaciones científicas se manifestaron en contra de lo enunciado y por ende la Asociación Colombiana de Menopausia consideró apropiado hacer una revisión exhaustiva del papel de la terapia hormonal en la actualidad. El resultado de dicho trabajo es presentado en esta revisión.


On January 2021 de Colombian Menopause Association did a symposium "Menopause hormonal therapy" with participation of respectable professors of the specialty, to each one previously a topic had been assigned for its review and presentation according to actual evidence. On November 2020 the Colombian Institute for Drugs and Foods Vigilance (INVIMA) had issued an alert about the "Risk of developing breast cancer in postmenopausal women under treatment with hormone replacement therapy", having support in a decision taken in the United Kingdom. One of the things affirmed by INVIMA was that prolonged use, greater than one year, increases the risk of breast cancer, without clear scientifically supporting this issue. In the United Kingdom the pronunciation was supported on the study, "Type and moment of menopausal hormone therapy and risk of breast cancer: Metanalisis of individual participants of worldwide epidemiological evidence, from the Collaborative group on hormonal factors in breast cancer published in The Lancet on August 29, 2019. Various scientific associations manifested against what was expressed and the Colombian Menopause Association considered appropriate to do an exhaustive review of the role of hormonal therapy today. The result of such work is presented in this paper.


Subject(s)
Humans , Female , Middle Aged , Hormone Replacement Therapy , Breast Neoplasms , Menopause , Estrogens , Heart Disease Risk Factors
8.
Einstein (Säo Paulo) ; 19: eAO5701, 2021. tab, graf
Article in English | LILACS | ID: biblio-1154090

ABSTRACT

ABSTRACT Objective: To examine epidemiologic, anthropometric and clinical variables associated with stress urinary incontinence in obese women, before and after bariatric surgery, and to identify predictive factors of stress urinary incontinence resolution. Methods: Prospective observational study with women enrolled in a bariatric surgery program between 2015 and 2016. Patients were assessed prior to and 6 months after bariatric surgery using the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, the Patient Global Impression of Improvement and the Visual Analogue Scale. Patient assessment also included physical examination and bladder stress tests. Results: A total of 43 women completed the study. There was a 72.7% reduction in stress urinary incontinence (p=0.021). Predictive factors for preoperative diagnosis of stress urinary incontinence included age (p=0.024) and abdominal waist circumference (p=0.048). Urinary symptoms improved after weight loss, especially nocturia (p=0.001) and stress urinary incontinence (p=0.026). Menopause was the most significant predictive factor for persistence of stress urinary incontinence within six months of bariatric surgery (p=0.046). Self-reported outcomes and scores obtained in the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, the Patient Global Impression of Improvement and the Visual Analogue Scale were associated with significant improvement (p=0.012, p=0.025, and p=0.002 respectively). Conclusion: Older women with larger waist circumference have a higher risk of developing stress urinary incontinence prior to bariatric surgery. Menopausal women are highly prone to persistent stress urinary incontinence, even after weight loss. Weight loss achieved through bariatric surgery improved stress urinary incontinence symptoms and mitigated related impacts on quality of life in the vast majority of women.


RESUMO Objetivo: Examinar as variáveis epidemiológicas, antropométricas e clínicas associadas à incontinência urinária de esforço em mulheres obesas antes e após a cirurgia bariátrica e identificar fatores preditivos da resolução desse tipo de incontinência. Métodos: Estudo observacional prospectivo com mulheres de um programa de cirurgia bariátrica, realizado entre 2015 e 2016. As pacientes responderam ao International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, à Clinical Global Impression-Improvement e à Escala Visual Analógica, sendo submetidas ao exame físico e ao teste de incontinência antes e 6 meses após cirurgia bariátrica. Resultados: Completaram o estudo 43 mulheres. Houve redução de 72,7% na incontinência urinária de esforço (p=0,021). Fatores preditivos para o diagnóstico pré-operatório da incontinência urinária incluíram idade (p=0,024) e circunferência abdominal (p=0,048). Todos os sintomas urinários demonstraram melhora após perda de peso, notadamente noctúria (p=0,001) e incontinência urinária de esforço (p=0,026). A menopausa foi o fator mais crítico para predizer a persistência da incontinência urinária de esforço 6 meses após a cirurgia bariátrica (p=0,046). Os resultados relatados do International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, da Patient Global Impression of Improvement e da Escala Visual Analógica tiveram melhora significativa (p=0,012, p=0,025, p=0,002, respectivamente). Conclusão: Mulheres idosas e com maior circunferência abdominal têm maior risco de desenvolver incontinência urinária de esforço antes da cirurgia. Mulheres na menopausa são fortemente propensas a persistir com a incontinência urinária de esforço, mesmo após a perda de peso. A perda de peso após a cirurgia bariátrica melhora os sintomas de incontinência urinária de esforço e seus impactos na qualidade de vida na maioria das mulheres.


Subject(s)
Humans , Female , Urinary Incontinence, Stress/etiology , Obesity, Morbid/surgery , Obesity, Morbid/complications , Bariatric Surgery , Quality of Life , Menopause , Prospective Studies , Surveys and Questionnaires , Age Factors , Treatment Outcome , Waist Circumference
9.
Rev. gaúch. enferm ; 42: e20190374, 2021. tab, graf
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1156646

ABSTRACT

ABSTRACT Objective: To describe the general characteristics of nursing professionals and assess the influence of overcommitment on perceived climacteric symptoms and on the quality of life of nursing professionals. Method: A cross-sectional, analytical study of 152 nursing auxiliaries and assistants aged 40 years or older was conducted at 3 hospitals in the interior of São Paulo state. Sociodemographic data were collected and the Blatt-Kupperman Menopausal Index, Women´s Health Questionnaire, Medical Outcome Study 36-item Short Form Health Survey and Effort-Reward Imbalance were applied in 2017. A descriptive analysis was performed and network analysis was carried out. Results: Participants had a mean age of 50.23 years (SD ±7.1). Group 1 comprising 61 (40.1%) women with overcommitment had poorer quality of life as well as more severe climacteric symptoms. Conclusions: Presence of overcommitment seems to influence the negative perception of climacteric symptomatology and quality of life.


RESUMEN Objetivo: Describir las características generales de los profesionales de enfermería y evaluar cómo el compromiso excesivo puede influir en la percepción de los síntomas del climaterio y la calidad de vida de estas mujeres. Métodos: Este es un estudio analítico de corte transversal que evaluó a 152 auxiliares de enfermería y técnicas en el grupo de edad de 40 años en 3 hospitales em el interior del estado de São Paulo. En 2017, se recopilaron los datos sociodemográficos y se aplicaron el Índice de Menopausia de Blatt-Kupperman, Women´s Health Questionnaire, El Cuestionario de Salud SF-36 y El Cuestionario Effort-reward Imbalance. Análisis descriptivo y análisis de red se realizó. Resultados: La edad promedio de los participantes fue de 50,23 años (DP = ± 7,1). Grupo 1 compuesto por 61 (40.1%) mujeres con compromiso excesivo fue la peor calidad de vida y la mayor intensidad de síntomas climáticos. Conclusiones: La presencia de compromiso excesivo parece influir en una percepción negativa de la sintomatología climática y una peor calidad de vida.


RESUMO Objetivo: Descrever as características gerais das profissionais de enfermagem e avaliar como o comprometimento excessivo pode influenciar na percepção dos sintomas do climatério e na qualidade de vida dessas mulheres. Método: trata-se de estudo transversal analítico, que avaliou 152 auxiliares e técnicas da enfermagem, na faixa etária de 40 anos ou mais, em 3 hospitais do interior do estado de São Paulo. Em 2017, foram coletados dados sociodemográficos e aplicados os instrumentos Índice Menopausal de Blatt-Kupperman, Questionário Saúde da Mulher, Medical Outcome Study 36-item short form Health Survey e Effort Reward Imbalance. Foi realizada análise descritiva e análise de rede. Resultados: A idade média das participantes foi de 50,23 anos (DP = ±7,1). O grupo 1, composto por 61(40,1%) mulheres com comprometimento excessivo apresentou pior qualidade de vida e maior intensidade de sintomas climatéricos. Conclusões: Presença de comprometimento excessivo parece influenciar em uma percepção negativa da sintomatologia do climatério e em uma pior qualidade de vida.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Perception , Quality of Life , Climacteric/psychology , Menopause , Women's Health , Nurse Practitioners , Cross-Sectional Studies , Surveys and Questionnaires , Occupational Stress , Work Engagement , Hospitals
10.
Clinics ; 76: e2380, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153943

ABSTRACT

OBJECTIVES: To compare the effects of low-dose conjugated estrogen (CE), raloxifene, and the combination thereof on the endometrium of postmenopausal women. METHODS: Postmenopausal women between 45 and 60 years of age, with Gail score≥1.67 and no endometrial disorders, were randomly assigned to receive low-dose CE (0.3 mg), raloxifene (60 mg), or combined therapy for 1 year. Transvaginal ultrasound was performed at baseline and every 3 months; the Kupperman Index was assessed at baseline and every 6 months. Endometrial biopsies were performed if endometrial thickness (ET) was ≥5 mm or if vaginal bleeding occurred. The primary outcome was the occurrence of ET≥5 mm over the one-year period. RESULTS: Seventy-three women were randomly assigned and analyzed on an intent-to-treat basis. Eight, three, and four women in the CE, raloxifene, and combination groups, respectively, exhibited ET≥5 mm. No genital bleeding was reported in the combination group. Endometrial biopsy revealed atrophy or polyps in all groups, with one patient in the CE group exhibiting a proliferative endometrium without atypia. At 6 months, there was a progressive increase in mean ET in the CE group, but not in the other two groups, with statistically significant differences at 6, 9, and 12 months. Mean scores for vasomotor symptoms and Kupperman Index favored the CE and combination groups over raloxifene. CONCLUSION: Combined raloxifene and low-dose CE decreased the severity of menopausal symptoms to a similar extent as CE alone and had similar effects as raloxifene alone on the endometrium.


Subject(s)
Humans , Female , Breast Neoplasms , Raloxifene Hydrochloride , Menopause , Double-Blind Method , Estrogens, Conjugated (USP) , Selective Estrogen Receptor Modulators , Endometrium/diagnostic imaging
11.
São Paulo; s.n; 2021. 147 p.
Thesis in English | LILACS | ID: biblio-1352373

ABSTRACT

Background: Cardiovascular disease is the leading cause of morbidity and mortality in women worldwide. Cardiovascular risk prediction is incomplete and new markers may help in the early identification of atherosclerosis. Brazilian epidemiological data in women are scarce. Objectives: To review the impact of menopause and diabetes on lipids, lipoprotein subfractions and cardiovascular risk; evaluate cardiometabolic risk in women from the ELSA-Brasil, as well as associations of blood biomarkers [lipoprotein subfractions, insulin resistance index (HOMA-IR) and branched-chain amino acids (BCAA)] and structural changes of atherosclerosis [presence of calcium in the coronary arteries (CAC)] according to age and menopausal status. Methods: Cross-sectional baseline analyzes of 2,258 female participants from the São Paulo site of the ELSA-Brasil, stratified by age and menopausal status, with specific sample and eligibility criteria for each paper. Descriptive statistics, between-group comparisons and multiple regression were performed according to the nature and distribution of the variables for each paper. Results: Paper 1: Literature revision enabled conclusions regarding the association of menopause and diabetes with a worse lipid profile, including hypertriglyceridemia, lower levels of HDL-c and HDL2-c, higher levels of HDL3-c and small dense LDL-c. Postmenopausal diabetic women consist of the highest cardiovascular risk level. Paper 2: Comparing pre- and postmenopausal women categorized according to time since menopause [menopausal duration <2 years, 2-5.9 years, 6-9.9 years or ≥ 10 years (n=1916)], postmenopausal women had a worse lipid and lipoprotein subfraction profile and duration of menopause <2 years was independently associated with remnant lipoprotein cholesterol (TRL-c) [7.21 mg/dL (95% CI 3.5910.84)] and smaller denser VLDL3-c [2.43 mg/dL (95%CI 1.023.83)], but no associations of menopausal categories with HDL-c or LDL-c subfractions were found, when taking premenopausal women as reference. Paper 3: Comparing premenopausal ≤ or >45 years and postmenopausal women (n=2047), postmenopausal ones had the worst cardiometabolic risk profile. CAC>0 was found to be associated with TRL-c and dense LDL-c, but not with BCAA levels nor HOMA-IR. Postmenopausal women were about twice as likely to have CAC>0 than younger premenopausal ones [OR 2.37 (95%CI 1.17-4.81)]. Discussion: Our findings suggest that natural menopause is associated with changes in lipoprotein fractions and subfractions (especially in the first 2 years post-menopause) and with calcium deposition in the coronary arteries independently of age and other risk factors, but not with BCAA nor HOMA-IR. Deep investigation on lipid profile and other biomarkers in women approaching to menopause is needed in order to identify cardiovascular risk, prevent cardiovascular outcomes and provide better health conditions.


Introdução: A doença cardiovascular se constitui na principal causa de morbimortalidade em mulheres globalmente. A predição de evento cardiovascular é incompleta e novos marcadores de risco cardiometabólico podem auxiliar na identificação precoce da aterosclerose. Dados epidemiológicos brasileiros no sexo feminino são mais escassos. Objetivos: Revisar o impacto da menopausa e diabetes nas lipoproteínas, subfrações e risco cardiovascular; avaliar o perfil de risco cardiometabólico de mulheres do ELSA-Brasil, bem como associações de marcadores sanguíneos [subfrações de lipoproteínas circulantes, índice de resistência à insulina (HOMA-IR) e aminoácidos de cadeia ramificada (BCAA)] e estruturais [cálcio nas artérias coronárias (CAC)] de aterosclerose segundo sua idade e estado menopausal. Métodos: Análise transversal de dados basais de 2258 mulheres acompanhadas no centro de São Paulo do ELSA-Brasil, estratificadas por idade e estado menopausal, respeitando características amostrais estabelecidas para cada artigo. Estatística descritiva, testes de comparação entre grupos e análises de regressão múltipla foram realizadas conforme natureza e distribuição das variáveis para cada artigo. Resultados: Artigo 1: A revisão da literatura permitiu concluir sobre a associação de menopausa e diabetes com pior perfil lipídico, consistindo de hipertrigliceridemia, baixos níveis de HDL-c e HDL2-c e elevados de HDL3-c e LDL-c pequena e densa. Mulheres menopausadas com diabetes apresentam o maior risco cardiovascular. Artigo 2: Comparando-se mulheres pré-menopausadas com as menopausadas, categorizadas segundo tempo de menopausa [duração <2 anos; 2-5,9 anos; 6-9,9 anos e ≥ 10 anos (n=1916)], aquelas na pós-menopausa apresentaram perfil de lipoproteínas e suas subfrações mais aterogênico e a duração da menopausa <2 anos associou-se independentemente com remanescentes de lipoproteínas ricas em triglicérides (TRL-c) [7,21 mg/dL (IC95% 3,5910,84)] e com a partícula pequena e densa de VLDL3-c [2,43 mg/dL (IC95% 1,023,83)], mas não foram encontradas associações de categorias de menopausa com as subfrações de HDL-c ou LDL-c, considerando-se as pré-menopausadas como referência. Artigo 3: Comparando mulheres pré-menopausadas com idade ≤ ou >45 anos e as menopausadas (n=2047), pior perfil de risco cardiometabólico foi encontrado em mulheres na pós- menopausa. Observou-se associação entre CAC>0 com TRL-c e LDL-c densa, mas não com HOMA-IR e BCAA. Mulheres menopausadas tiveram cerca de 2 vezes mais chance de apresentar CAC>0 quando comparadas com mulheres mais jovens na pré-menopausa [OR 2,37 (IC95% 1,17-4,81)]. Discussão: Nossos achados sugerem que a menopausa natural está associada a alterações no perfil lipídico tradicional e subfrações (especialmente nos primeiros 2 anos pós-menopausa) e ao depósito de cálcio nas artérias coronárias independentemente da idade e de outros fatores de risco, mas não com BCAA e HOMA-IR. Investigação aprofundada do perfil lipídico e outros marcadores de risco cardiovascular em mulheres que se aproximam da menopausa pode melhorar a identificação de risco, prevenção de desfechos cardiovasculares e proporcionar melhores condições de saúde.


Subject(s)
Women , Menopause , Biomarkers , Atherosclerosis , Heart Disease Risk Factors , Amino Acids, Branched-Chain , Lipoproteins , Women's Health
12.
Rev. méd. Minas Gerais ; 31: 31206, 2021.
Article in English, Portuguese | LILACS | ID: biblio-1291278

ABSTRACT

A menopausa é decorrente da queda gradativa de secreção hormonal ovariana e, nesse período, muitas mulheres apresentam sintomas que comprometem a qualidade de vida. A terapia hormonal (TH) surgiu como importante ferramenta para amenizar a sintomatologia climatérica. No entanto, foram levantadas suspeitas sobre a correlação entre o tratamento e o aumento do risco do câncer de mama (CM). O presente trabalho objetiva avaliar a relação entre CM e TH, abrangendo as implicações da terapia nos sintomas da menopausa, na incidência da neoplasia e na mortalidade. Trata-se de uma revisão narrativa de literatura, em que foram buscados artigos publicados entre julho de 2010 e julho de 2020, nas bases de dados LILACS, MEDLINE e SciELO. Os principais tipos de TH são o estrogênio isolado e o combinado com progesterona. Nos estudos analisados, a terapia combinada foi relacionada à maior incidência de CM quando comparada ao regime estrogênico. De acordo com a literatura, modificações na densidade mamográfica, induzidas pela TH, podem elevar o risco para carcinoma mamário. Os artigos relataram que fatores além da terapia hormonal, como o estilo de vida, podem interferir na incidência de CM e devem ser analisados individualmente. A mortalidade por CM influenciada pela TH não demonstrou aumento significativo. No geral, a TH foi considerada o tratamento mais eficaz para aliviar sintomas climatéricos. Entretanto, estudos a longo prazo que analisem os riscos e a confiabilidade da terapia devem ser estimulados, a fim de indicar a terapêutica mais segura e evitar intervenções indevidas.


Menopause is due to the gradual drop in ovarian hormonal secretion, and, during this period, many women have symptoms that compromise quality of life. Hormone therapy (HT) has emerged as an important tool to alleviate climacteric symptoms. However, suspicions were raised about the correlation between treatment and the increased risk of breast cancer (BC). The present study aims to evaluate the relationship between BC and HT, covering the implications of therapy for menopausal symptoms, the incidence of neoplasia and mortality. This is a narrative review of the literature, in which articles published between July 2010 and July 2020 were searched for in the LILACS, MEDLINE and SciELO databases. The main types of HT are estrogen alone and combined formula with progesterone. In the studies analyzed, combined therapy was related to a higher incidence of BC when compared to the estrogenic regimen. According to the literature, changes in mammographic density, induced by HT, can increase the risk for breast carcinoma. The articles reported that factors other than hormone therapy, such as lifestyle, can interfere with the incidence of BC and should be analyzed individually. Mortality from BC influenced by HT did not show a significant increase. Overall, HT was considered to be the most effective treatment for relieving climacteric symptoms. Although, long-term studies that analyze the risks and reliability of therapy should be encouraged in order to indicate the safest therapeutics and to avoid unnecessary interventions.


Subject(s)
Female , Middle Aged , Breast Neoplasms , Hormone Replacement Therapy , Climacteric , Menopause , Estrogen Replacement Therapy , Hormones
13.
Rev. Assoc. Med. Bras. (1992) ; 66(12): 1628-1632, Dec. 2020. tab
Article in English | LILACS, SES-SP | ID: biblio-1143667

ABSTRACT

SUMMARY OBJECTIVE: Hot flashes have a negative impact on the quality of life of women during the menopausal transition and thereafter. The progressive reduction in gonadal estrogen levels associated with aging promotes an accumulation of abdominal fat, dyslipidemia, and arterial hypertension, all of which are components of metabolic syndrome (MetS). The objective of the present study was to estimate the prevalence of hot flashes and evaluate their relationship with MetS in women ≥ 40 years of age. METHODS: This was a cross-sectional study involving women aged between 40 and 65 years. We used the Kupperman index to quantify the climacteric symptoms and the National Cholesterol Education Program Adult Treatment Panel III criteria for the diagnosis of MetS. RESULTS: 1,435 women were initially selected, and we obtained information from 647. The mean age at menopause was 45.99 years (SD 6.61 years) and the prevalence of hot flashes and MetS were 55.83% (95% CI: 52.35-59.25%) and 46.29% (95% CI: 44.75-52.53%), respectively. We identified a positive association between MetS and hot flashes (OR 1.16; 95% CI: 1.01-1.33). CONCLUSIONS: In women ≥ 40 years of age, hot flashes are highly prevalent and appear to be associated with MetS.


RESUMO OBJETIVO: As ondas de calor têm um impacto negativo na qualidade de vida das mulheres no climatério. A redução progressiva dos níveis de estrogênio gonadal associada ao envelhecimento promovem o acúmulo de gordura abdominal, dislipidemia e hipertensão arterial, componentes da síndrome metabólica (SM). O objetivo do presente estudo foi estimar a prevalência de ondas de calor e avaliar sua relação com SM em mulheres com idade ≥40 anos. MÉTODOS: Estudo transversal envolvendo mulheres entre 40 e 65 anos de idade. Utilizamos o índice de Kupperman para quantificar os sintomas climatéricos e os critérios do National Cholesterol Education Program Adult Treatment Panel III para o diagnóstico de SM. RESULTADOS: Mil, quatrocentas e trinta e cinco mulheres foram selecionadas inicialmente e obtivemos informações de 647. A idade média da menopausa foi de 45,99 anos (DP 6,61 anos) e a prevalência de ondas de calor e SM foi de 55,83% (95% CI: 52,35-59,25%) e 46,29% (95% CI: 44,75-52,53%), respectivamente. Identificamos uma associação positiva entre SM e ondas de calor (OR 1,16; IC95%: 1,01-1,33). CONCLUSÕES: Em mulheres com idade ≥40 anos, as ondas de calor são altamente prevalentes e parecem estar associadas a SM.


Subject(s)
Humans , Female , Adult , Aged , Hot Flashes/epidemiology , Metabolic Syndrome/epidemiology , Quality of Life , Menopause , Prevalence , Cross-Sectional Studies , Middle Aged
14.
Int. braz. j. urol ; 46(5): 716-724, Sept.-Oct. 2020. tab, graf
Article in English | LILACS | ID: biblio-1134212

ABSTRACT

ABSTRACT Purpose: We aimed to investigate the effects of menopause on long-term outcomes of transobturator tape (TOT) surgery. Materials and Methods: Patients who underwent TOT surgery were evaluated under two groups as postmenopausal and premenopausal. The International Consultation on Incontinence short-form questionnaire (ICIQ-SF), Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory-Short Form (UDI-6) questionnaires were completed by the patients at the 1st and 5th-year follow-up sessions. Patients with a postoperative UDI-6 and IIQ-7 score of <10 were considered as cured, those with lower postoperative scores compared to the preoperative period were regarded as improved, and the cases that had higher postoperative scores than preoperative values were interpreted as TOT failure. The TOT success rates were compared between the results obtained from UDI-6 and IIQ-7. Results: A total of 109 patients were included in the study (53 postmenopausal and 56 premenopausal). We contacted with 90 (48 premenopausal and 42 postmenopausal) women at 1st year control and 80 (44 premenopausal and 36 postmenopausal) women at 5th year control. There was a significant improvement in all of three questionnaires between the preoperative and post-operative 1st year control (ICIQ-SF: 15.5±2.5 vs. 1.8±4.3, p <0.001; IIQ-7: 68.9±9.8 vs. 2.75±15.2, p <0.001; UDI-6: 27.1±11.1 vs. 6.0±14.6, p <0.001) and the preoperative and post-operative 5th year control (ICIQ-SF: 15.5±2.5 vs. 3.1±5.3, p <0.001; IIQ-7: 68.9±9.8 vs. 9.6±26.7, p <0.001; UDI-6: 27.1±11.1 vs. 5.1±10.0, p <0.001). When we compared the premenopausal and postmenopausal patients in terms of recurrent urinary tract infection (UTI); 5 (12%) patients had recurrent UTI in postmenopausal group but no patients had recurrent UTI in premenopausal group at 1st year follow-up (p=0.039) and similarly the same 5 (13.9%) patients in follow-up had recurrent UTI in postmenopausal group but no patients had recurrent UTI in premenopausal group at 5th year follow-up (p=0.045). There were no significant differences between the premenopausal and postmenopausal patients in terms of TOT success rates at 1st and 5th year control, evaluated with UDI-6 (1st year: p=0.198 and 5th year: p=0.687) and IIQ-7 (1st year: p=0.489 and 5th year: p=0.608) questionnaires. Conclusions: Transobturator tape surgery is an effective and reliable method according to the long-term outcomes reported in this paper. In the current study, we determined that the TOT success rates were not affected by the presence of menopause.


Subject(s)
Humans , Female , Urinary Incontinence , Urinary Incontinence, Stress/surgery , Suburethral Slings , Quality of Life , Menopause , Surveys and Questionnaires , Treatment Outcome
15.
Rev. bras. anal. clin ; 52(3): 238-242, 20200930. tab, graf
Article in Portuguese | LILACS | ID: biblio-1255090

ABSTRACT

Objetivo: Caracterizar o perfil dos hormônios tireoidianos de mulheres com idade maior ou igual a 50 anos atendidas no Laboratório Municipal de Referência Regional de Serrinha (LMRRS) no ano de 2017. Métodos: Os resultados de T3, T4 livre e TSH foram coletados retrospectivamente através do sistema informatizado utilizado pelo laboratório para construção de uma base de dados, e analisados de acordo com valores de referência recomendados pela Sociedade Brasileira de Endocrinologia. Resultados: Foi encontrada uma prevalência moderada de disfunções tireoidianas, sendo 58,62% de casos de hipotireoidismo e 41,38% de hipertireoidismo. Houve também aumento dos níveis de TSH e T4 livre entre os 50 e 70 anos, sem alterações nos níveis de T3 total. Conclusão: Os resultados assemelham-se a estudos anteriores, envolvendo outras populações, com predomínio do hipotireoidismo subclínico entre mulheres na mesma faixa etária. No entanto, a tendência crescente dos níveis de T4 livre não reflete os achados prévios que associam o avanço da idade e redução da produção de estrogênios com a diminuição da função tireoidiana.


Objective: To characterize the thyroid hormone profile of women aged 50 years and older attended at the Laboratório Municipal de Referência Regional de Serrinha (LMRRS) in the year 2017. Methods: The results of T3, free T4 and TSH were retrospectively collected from the computerized system of laboratory for building a database, and analyzed according to the reference values recommended by the Brazilian Society of Endocrinology. Results: A moderate prevalence of thyroid dysfunction was found, with 58.62% of cases of hypothyroidism and 41.38% of hyperthyroidism. There was also an increase of TSH and free T4 levels between 50 and 70 years with no changes in total T3 levels. Conclusion: The results are similar to previous studies involving other populations, with a prevalence of subclinical hypothyroidism in women in the same age group. However, the increasing trend of free T4 levels does not reflect the previous findings that associate the advancement of age and reduction of estrogen production with the decrease of thyroid function.


Subject(s)
Humans , Female , Middle Aged , Aged , Aged, 80 and over , Thyroid Gland , Thyroid Hormones , Menopause , Hyperthyroidism , Hypothyroidism
16.
Actual. osteol ; 16(2): 140-153, mayo.-ago. 2020. ilus, graf
Article in Spanish | LILACS | ID: biblio-1129814

ABSTRACT

La osteoporosis y las enfermedades cardiovasculares son patologías prevalentes en mujeres posmenopáusicas. La calcificación vascular es un proceso en el que se produce una distorsión de la arquitectura natural del tejido arterial con una transformación símil osteogénica. La fisiología vascular y la osteogénesis (formación y remodelación ósea) comparten una complejidad metabólica y funcional crítica, que ha sido poco explorada en forma conjunta, lo que ha impulsado la concepción del Eje Óseo-Vascular como nueva área de investigación, con una visión de estudio integradora con la finalidad de identificar vínculos entre ambos sistemas. En virtud de la controversia planteada sobre los riesgos/beneficios de la terapia de reemplazo hormonal para prevenir enfermedades asociadas a la menopausia, se ha incentivado la búsqueda de nuevas opciones de tratamiento. Los fitoestrógenos, como compuestos nutracéuticos, surgen como una potencial alternativa terapéutica. En particular, las isoflavonas presentan gran analogía estructural con el estrógeno humano 17ß-estradiol, lo que les permite unirse al receptor de estrógenos e inducir acciones estrogénicas tanto en células animales como humanas. Basado en la experiencia propia como en lo reportado en la bibliografía, este artículo analiza la información disponible sobre las acciones vasculares y óseas de los fitoestrógenos (específicamente la isoflavona genisteína), con una visión de ciencia traslacional. Es de esperar que los avances en el conocimiento derivado de la ciencia básica, en un futuro cercano, pueda contribuir a decisiones clínicas a favor de promover terapias naturales de potencial acción dual, para la prevención de enfermedades de alta prevalencia y significativo costo social y económico para la población. (AU)


Osteoporosis and cardiovascular diseases are prevalent diseases in postmenopausal women. Vascular calcification is a cellmediated process that leads to the loss of the natural architecture of the arterial vessels due to osteogenic transdifferentiation of smooth muscle cells, and matrix mineralization. Vascular physiology and osteogenesis (bone formation and remodeling) share a critical metabolic and functional complexity. Given the emerging integrative nature of the bonevascular axis, links between both systems are a matter of ongoing interest. In view of the controversy stated about the risks/benefits of hormone replacement therapy to prevent diseases associated with menopause, phytoestrogens arise as a potential natural therapeutic alternative. In particular, isoflavones have a strong structural analogy with the human estrogen 17ß-estradiol, that allows them to bind to the estrogen receptor and induce estrogenic actions in animal and human cells. Based in on our own experience and the information available in the literature, in this paper we provide an overview of the role of phytoestrogens on vascular and bone tissues, with focus on Genistein actions. We wish that the basic knowledge acquired may contribute to guide clinical decisions for the promotion of natural therapies for the treatment of diseases that conspire against human health. (AU)


Subject(s)
Humans , Male , Female , Osteogenesis/drug effects , Phytoestrogens/therapeutic use , Atherosclerosis/drug therapy , Vascular Calcification/drug therapy , Osteogenesis/physiology , Menopause , Cardiovascular Diseases/complications , Osteoporosis, Postmenopausal , Bone Remodeling , Genistein/therapeutic use , Phytoestrogens/classification , Phytoestrogens/pharmacology , Atherosclerosis/physiopathology , Estrogens/biosynthesis , Vascular Calcification/physiopathology , Vascular Calcification/metabolism
17.
Arch. med ; 20(2): 282-294, 20200703.
Article in Spanish | LILACS | ID: biblio-1118581

ABSTRACT

Objetivo: evaluar la efectividad y seguridad del policresuleno frente al estriol y el lubricante vaginal, en el tratamiento del síndrome genitourinario de la menopausia en mujeres de Armenia (Quindío, Colombia). Materiales y métodos: en mujeres diagnosticadas con síndrome genitourinario de la menopausia, se hizo un ensayo clínico controlado aleatorizado y triple ciego. Se asignaron tres grupos (estriol, n=86, lubricante vaginal, n=83 y policresuleno, n=82). El principal parámetro indicador de efectividad fue la elevación de la puntuación del índice de salud vaginal (ISV), mejoría de la función sexual de acuerdo al índice de Función Sexual Femenina Abreviado-6 (IFSFA-6), porcentaje de mejoría de la sintomatología e incidencia de efectos adversos.Resultados: la efectividad fue mayor con el uso del estriol, seguida del policresuleno y menor con el lubricante vaginal (92,82%, 75,69% y 63,74%, respectivamente, p =0,012); también se encontraron diferencias en la mejoría de la función sexual, según los puntajes del IFSFA-6 [29,29 ± 6,23 (estriol), 28,66 ± 6,12 (policresuleno) y 25,38 ± 6,27 (lubricante vaginal), p = 0,021], con diferencias en el porcentaje tanto de la mejoría de la sintomatología como en la presentación de efectos adversos (p = 0,001). Conclusiones: el policresuleno tiene una significativa efectividad en el tratamiento del síndrome genitourinario de la menopausia, superior frente al lubricante vaginal,pero inferior comparado con el estriol. Es evidente la presencia de efectos adversos, mayores con el estriol, seguido del policresuleno y luego del lubricante vaginal, sin cuestionar el notable perfil de seguridad del policresuleno..Au


Objective: to evaluate the effectiveness and safety of policresulen against estriol and vaginal lubricant in the treatment of menopausal genitourinary syndrome in women from Armenia (Quindío, Colombia). Materials and methods: in women diagnosed with genitourinary menopausal syndrome, a randomized, three-blind, controlled clinical trial was conducted. Three groups were assigned (estriol, n = 86, vaginal lubricant, n = 83 and policresulen, n = 82). The main indicator parameter of effectiveness was the elevation of the vaginal health index (ISV) score, improvement in sexual function according to the Abbreviated Female Sexual Function Index-6 (IFSFA-6), percentage of improvement in symptoms and incidence of adverse effects. Results: the effectiveness was greater with the use of estriol, followed by policresulen and less with the vaginal lubricant (92.82%, 75.69% and 63.74%, respectively, p = 0.012); Differences were also found in the improvement of sexual function, according to IFSFA-6 scores [29.29 ± 6.23 (estriol), 28.66 ± 6.12 (policresulen) and 25.38 ± 6.27 (vaginal lubricant), p = 0.021], with differences in the percentage of both improvement in symptoms and in the presentation of adverse effects (p = 0.001). Conclusions: polycresullen has a significant effectiveness in the treatment of genitourinary syndrome of menopause, superior compared to vaginal lubricant, but inferior when compared to estriol. The presence of adverse effects is evident, greater with estriol, followed by policresulen and then vaginal lubricant, without questioning the remarkable safety profile of polyresulin..Au


Subject(s)
Menopause , Female Urogenital Diseases
18.
Enferm. foco (Brasília) ; 11(1): 44-49, jun. 2020.
Article in Portuguese | LILACS, BDENF | ID: biblio-1102523

ABSTRACT

Objetivo: conhecer o que as mulheres e os homens com vínculo trabalhista ou estudantil da Universidade Federal de São João del-Rei, Campus Centro-Oeste, sabem sobre o climatério e menopausa. Metodologia: estudo de caso único, com abordagem qualitativa e fundamentada na técnica de Análise Crítica do Discurso. A pesquisa contou com 43 participantes, sendo 15 mulheres e 28 homens. Resultados: a distinção entre climatério e menopausa nem sempre é clara para os participantes, sendo desconhecidas, especialmente, pelos participantes do sexo masculino. Além disso, o climatério é um período em que as mulheres queixam-se de vários sintomas, tanto biológicos quanto psicológicos. Considerações finais: há uma defasagem no conhecimento das mulheres referente ao climatério e à menopausa. Nota-se o desconhecimento total dos homens referente ao climatério e poucos sabem o que é a menopausa. Em face ao exposto evidencia-se a necessidade de mais estudos que busquem explorar a temática menopausa/ climatério. (AU)


Objective: to know the that women and men with a labor or student bond of the Federal University of São João del-Rei, Campus Central-West, know about the climacteric and menopause. Method: a unique case study, with a qualitative approach and based on the technique of Critical Discourse Analysis. The survey counted on 43 participants, being 15 women and 28 men. Results: the distinction between the phases of female life understood by the climacteric and the menopause is not always clear to the participants, being unknown, especially, by the male participants. In addition, it is a time when women complain of various symptoms, both biological and psychological. Conclusion: there is a lag in women's knowledge regarding such periods. Men's total ignorance of the climacteric is noted, and few know what menopause is. In view of the above, it is evident the need for further studies that seek to explore the menopausal / climacteric theme. (AU)


Objetivo: conocer el desarrollo que las mujeres y los hombres con vínculo laboral o estudiantil de la Universidad Federal de San Juan del Rey, Campus Centro-Oeste, saben sobre el climaterio y la menopausia. Metodo: estudio de caso único, con abordaje cualitativo y fundamentado en la técnica de Análisis Crítico del Discurso. La encuesta contó con 43 participantes, siendo 15 mujeres y 28 hombres. Resultados: la distinción entre las fases de la vida femenina comprendidas por el climaterio y la menopausia no siempre es clara para los participantes, siendo desconocidas, especialmente, por los participantes del sexo masculino. Además, es un período en que las mujeres se quejan de varios síntomas, tanto biológicos y psicológicos. Conclusión: hay un desfase en el conocimiento de las mujeres referente a tales períodos. Se nota el desconocimiento total de los hombres referente al climaterio y pocos saben lo que es la menopausia. En vista de lo expuesto se evidencia la necesidad de más estudios que busquen explorar la temática menopausia / climaterio. (AU)


Subject(s)
Women , Humans , Climacteric , Menopause , Knowledge
19.
Fisioter. Bras ; 21(2): 189-196, Mai 16, 2020.
Article in Portuguese | LILACS | ID: biblio-1282964

ABSTRACT

Introdução: O climatério é um período marcado por transformações no corpo feminino, desse modo, diversos problemas como: redução da lubrificação vaginal, anorgasmia e dispareunia podem surgir ou se agravar e, como consequência, há uma diminuição na qualidade de vida. Objetivo: Analisar a relação da função sexual e a qualidade de vida em mulheres climatéricas. Métodos: Trata-se de um estudo observacional, de corte transversal, analítico. A coleta de dados foi realizada com 20 mulheres climatéricas com faixa etária de 38 a 60 anos. Como instrumentos foram utilizados questionários contendo dados sociodemográficos, o Female Sexual Function Index para avaliar a função sexual e o World Health Organization Quality of Life (WHOQOLBREF) para analisar a qualidade de vida. Resultados: Foi observado que nas mulheres que possuem disfunção sexual no domínio excitação, a média está abaixo do ponto de corte, o que não ocorre com mulheres que não possuem disfunção (p = 0,03), o mesmo ocorre com os domínios orgasmo e satisfação. Na correlação da função sexual com a qualidade de vida, há significância estatística nos domínios físico (p = 0,023) e meio ambiente (p = 0,049). Conclusão: Constatou-se que nas mulheres que possuem uma qualidade de vida reduzida os impactos da disfunção sexual são maiores. (AU)


Introduction: The climacteric period is a stage characterized by changes in women's bodies this way, numerous issues such as the decrease of vaginal lubrication, anorgasmia and dyspareunia may come up and be aggravated consequently promoting a reduction in the quality of life. Objective: To assess the relation between sexual functioning and life's quality in climacteric women. Methods: It is an observational and analytical study, with a cross-sectional design. The data collection was carried with 20 climacteric women aged from 38 to 60 years old. As instruments were used questionnaires that comprised sociodemographic data, the Female Sexual Function Index to examine the sexual function and the World Health Organization Quality of Life WHOQOL-BREF to assess life's quality. Results: It was noted that for women who have had sexual dysfunction in the excitation domain, the mean was below the cutoff point what does not happen with women who did not have dysfunction (p = 0,03), the same happens with orgasm and satisfaction domains. Correlating sexual function with life's quality, the physical (p = 0,023) and environmental (p = 0,049) present statistical significance. Conclusion: It was determined that for women who have a reduced quality of life the sexual dysfunction impacts are larger. (AU)


Subject(s)
Humans , Female , Quality of Life , Climacteric , Menopause , Sexual Health
20.
Ciênc. Saúde Colet ; 25(2): 645-654, Feb. 2020. tab
Article in English | LILACS | ID: biblio-1055836

ABSTRACT

Abstract The hormonal changes in climacteric women may affect the vestibular system; however, it is not clear in the literature whether the presence of vestibular dysfunction associated with climacteric is related to poorer quality of life. The study sample was composed of 374 women (40-65 years). Socioeconomic and demographic data, menopausal status, practice of physical exercises, presence or absence of vestibular dysfunction, hypertension and diabetes, anthropometric measurements and quality of life (using the Utian Quality of Life Scale - UQoL) were collected. Statistical analyses were performed using the Pearson test, Anova, T-test, and multiple regression considering a significance level of 5%. A significant relationship was found between vestibular dysfunction and health (p = 0.02) and emotional (p = 0.01) domains of the UQoL. In addition, physical activity, menopausal status, body mass index (BMI), waist-hip ratio (WHR), household income and diastolic blood pressure (DBP) mean also remained significantly related to quality of life. A relationship between vestibular dysfunction and quality of life for health and emotional domains in climacteric women was observed.


Resumo Mudanças hormonais em mulheres climatéricas podem afetar o sistema vestibular, porém, não está claro na literatura se a presença da disfunção vestibular associada ao climatério está relacionada à pior qualidade de vida. O objetivo deste artigo é analisar a relação entre disfunção vestibular e qualidade de vida em mulheres climatéricas. Amostra composta por 374 mulheres (40 a 65 anos). Foram coletados dados socioeconômicos e demográficos, status menopausal, prática de exercício físico, presença ou ausência de disfunção vestibular, hipertensão e diabetes, medidas antropométricas e qualidade de vida (por meio do Utian Quality of Life Scale - UQoL). Na análise estatística foi utilizado teste de Pearson, Anova, teste t e regressão múltipla, considerando nível de significância de 5%. Verificou-se relação significativa entre a disfunção vestibular e os domínios saúde (p = 0,02) e emocional (p = 0,01) do UQoL. Além disso, atividade física, status menopausal, IMC (índice de massa corporal), RCQ (relação cintura-quadril), renda familiar e média da PAD (pressão arterial diastólica) também permaneceram significantemente relacionadas à qualidade de vida. Observou-se relação entre disfunção vestibular e qualidade de vida para os domínios saúde e emocional em mulheres climatéricas.


Subject(s)
Humans , Female , Adult , Aged , Quality of Life , Menopause/physiology , Vestibular Diseases/epidemiology , Blood Pressure/physiology , Exercise/psychology , Body Mass Index , Cross-Sectional Studies , Waist-Hip Ratio , Income , Middle Aged
SELECTION OF CITATIONS
SEARCH DETAIL