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1.
Indian J Biochem Biophys ; 2014 Oct; 51(5): 416-419
Article in English | IMSEAR | ID: sea-154274

ABSTRACT

In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 µg/ml was evaluated against eight human cancer cell lines — A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.


Subject(s)
Antineoplastic Agents/pharmacology , Apoptosis/drug effects , Cell Survival/drug effects , Dose-Response Relationship, Drug , Humans , Mentha/chemistry , Mentha/classification , Neoplasms, Experimental/drug therapy , Neoplasms, Experimental/pathology , Plant Extracts/pharmacology , Species Specificity
2.
Rev. bras. plantas med ; Rev. bras. plantas med;11(2): 137-140, 2009. tab
Article in Portuguese | LILACS | ID: lil-614836

ABSTRACT

As plantas medicinais produzem seus princípios ativos de acordo com os estímulos do ambiente, por isso a presença de outras plantas pode comprometer a produção dos metabólicos secundários. Assim, o presente trabalho teve como objetivo avaliar o efeito do cultivo consorciado sobre a produção de fitomassa e o teor de óleo essencial de manjericão (Ocimum basilicum L.) e hortelã (Mentha x villosa Huds.). O experimento foi conduzido na área experimental do Núcleo de Ciências Agrárias da Universidade Federal de Minas Gerais, Campus Regional de Montes Claros- MG. O delineamento utilizado foi o de blocos casualizados, com doze repetições, compreendendo seis tratamentos: manjericão + cenoura, manjericão + alface, manjericão solteiro, hortelã + cenoura, hortelã + alface e hortelã solteira. A produção de fitomassa e óleo essencial da hortelã não foram influenciados pelos tratamentos. Para o manjericão, apenas a massa fresca variou significativamente com os tratamentos.


Medicinal plants produce their active principles according to environmental stimuli; thus, the presence of other plants may affect the synthesis of secondary compounds. The present work aimed to evaluate the effect of intercropping on phytomass and essential oil production in basil (Ocimum basilicum L.) and mint (Mentha x villosa Huds.). The study was carried out in the experimental field of the Center for Agriculture, Federal University of Minas Gerais, Montes Claros Campus, Minas Gerais State, Brazil. The experimental design was in randomized blocks, with twelve replicates and six treatments: basil + carrot, basil + lettuce, sole crop of basil, mint + carrot, mint + lettuce, and sole crop of mint. Phytomass and essential oil production in mint were not affected by the treatments. As regards basil, only fresh matter significantly varied with treatments.


Subject(s)
Oils, Volatile/pharmacology , Ocimum basilicum/classification , Mentha/classification , Plants, Medicinal/classification
3.
Rev. bras. plantas med ; Rev. bras. plantas med;11(2): 164-169, 2009. graf, tab
Article in Portuguese | LILACS | ID: lil-614841

ABSTRACT

Hyptis marrubioides Epling (hortelã-do-campo) é espécie de uso medicinal conhecida pelas suas atividades contra infecções gastrointestinais, infecções de pele, dores e câimbras. Objetivou-se com este trabalho, avaliar o teor e composição química do óleo essencial de H. marrubioides em diferentes genótipos (roxo e branco) e partes da planta fresca (folhas, inflorescências e caule). Os genótipos estudados foram identificados através das inflorescências das plantas que apresentam coloração roxa e branca. O delineamento experimental foi inteiramente casualizado, contendo as três partes da planta de ambos os genótipos, perfazendo um fatorial 3x2, com quatro repetições. O óleo essencial foi extraído por hidrodestilação por duas horas e analisado por Cromatografia Gasosa acoplada a Espectrometria de Massas (CG-EM). O maior teor de óleo essencial foi observado na inflorescência do genótipo roxo. A composição do óleo essencial de H. marrubioides variou quantitativamente entre as partes das plantas analisadas e entre os genótipos. O composto α-tujona apresentou a maior porcentagem de área do pico nas inflorescências de genótipo roxo. As porcentagens das plantas com genótipo roxo foram em média superiores às plantas com genótipo branco.


Hyptis marrubioides Epling ("hortelã-do-campo") is a medicinal species known for its activities against gastrointestinal and skin infections, pains and cramps. The aim of this work was to evaluate essential oil content and chemical composition in H. marrubioides of different genotypes (purple and white), as well as fresh plant parts (leaves, inflorescences and stem). The studied genotypes were identified based on the inflorescences, which are purple and white. The experimental design was completely randomized, including the three parts of both genotypes, in a 3X2 factorial arrangement, with four replicates. Essential oil was extracted through hydrodistillation for two hours and analyzed using Gas Chromatography attached to a Mass Spectrometry (GC-MS). The highest essential oil content was found for the inflorescence of purple genotype. Hyptis marrubioides essential oil composition quantitatively varied among the analyzed plant parts and between genotypes. The compound α-thujone had the highest percentage of apex area in inflorescences of purple genotype. The percentages of purple genotype were on average higher than those of white one.


Subject(s)
Oils, Volatile/chemistry , Chemistry , Hyptis/physiology , Genotype , Plants, Medicinal/classification , Chromatography, Gas/methods , Mentha/classification
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