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1.
Article in English | WPRIM | ID: wpr-922572

ABSTRACT

OBJECTIVE@#To explore the mechanisms of Dangua Recipe (DGR) in improving glycolipid metabolism based on transcriptomics.@*METHODS@#Sprague-Dawley rats with normal glucose level were divided into 3 groups according to a random number table, including a conventional diet group (Group A), a DGR group (Group B, high-calorie diet + 20.5 g DGR), and a high-calorie fodder model group (Group C). After 12 weeks of intervention, the liver tissue of rats was taken. Gene sequence and transcriptional analysis were performed to identify the key genes related to glycolipid metabolism reflecting DGR efficacy, and then gene or protein validation of liver tissue were performed. Nicotinamide phosphoribosyl transferase (Nampt) and phosphoenolpyruvate carboxykinase (PEPCK) proteins in liver tissues were detected by enzyme linked immunosorbent assay, fatty acid synthase (FASN) protein was detected by Western blot, and fatty acid binding protein 5 (FABP5)-mRNA was detected by quantitative real-time polymerase chain reaction. Furthermore, the functional verification was performed on the diabetic model rats by Nampt blocker (GEN-617) injected in vivo. Hemoglobin A@*RESULTS@#Totally, 257 differential-dominant genes of Group A vs. Group C and 392 differential-dominant genes of Group B vs. Group C were found. Moreover, 11 Gene Ontology molecular function terms and 7 Kyoto Encyclopedia of Genes and Genomes enrichment pathways owned by both Group A vs. Group C and Group C vs. Group B were confirmed. The liver tissue target validation showed that Nampt, FASN, PEPCK protein and FABP5-mRNA had the same changes consistent with transcriptome. The in vivo functional tests showed that GEN-617 increased body weight, HbA@*CONCLUSION@#Nampt activation was one of the mechanisms about DGR regulating glycolipid metabolism.


Subject(s)
Animals , Diabetes Mellitus, Experimental , Drugs, Chinese Herbal , Glycolipids , Liver , Metabolic Diseases , Rats , Rats, Sprague-Dawley , Transcriptome/genetics
2.
Arch. latinoam. nutr ; 71(4): 281-289, dic. 2021. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1355216

ABSTRACT

Conocer la asociación específica de las enfermedades metabólicas en la mortalidad por COVID-19, ocurrida en México durante el año crítico de la pandemia de marzo 2020 a marzo 2021. Método. Se utilizó la base nacional de COVID-19 de la Dirección General de Epidemiología. Se analizaron los casos positivos que presentaron las enfermedades metabólicas: cardiovasculares, hipertensión, diabetes y obesidad. Se realizó un análisis descriptivo para conocer la distribución de los casos fallecidos y no fallecidos. Se empleó la prueba de ji cuadrada para la diferencia de las proporciones. Se utilizaron análisis de regresión logística para conocer la asociación entre las enfermedades metabólicas y la mortalidad por COVID-19 en personas positivas al virus SARS-CoV-2. Los datos fueron ajustados por edad y sexo. Resultados. Se observó la asociación de las enfermedades metabólicas en la mortalidad. La diabetes tuvo mayor porcentaje de letalidad 18,4%. Cuando se conjuntaron las enfermedades cardiovasculares y diabetes el porcentaje de letalidad subió a 31,5%; la conjunción de las enfermedades cardiovasculares, con hipertensión y diabetes fue la de mayor porcentaje de letalidad 38,7%. La obesidad fue la que tuvo menor incidencia. Conclusiones. Las enfermedades metabólicas en México son un problema de salud pública que afectó la mortalidad por covid-19. Es prioritario atender con políticas públicas preventivas y efectivas en favor de un modelo de consumo alimentario sano, acorde con las necesidades nutrimentales de la población(AU)


To know the specific association of metabolic disease on COVID-19 mortality, occurred during the critical year of the pandemic, from march 2020 to march 2021. Method: The Covid-19 national base of the General Directorate of Epidemiology was used. Positive cases of metabolic diseases were analyzed: cardiovascular disease, hypertension, diabetes and obesity. A descriptive analysis was carried out to find out the distribution of deceased and non-deceased cases. The chi-square test was used for the difference in proportions. Logistic regression analysis was used to understand the association between metabolic diseases and COVID 19 mortality in people who tested positive for the SARS-CoV-2 virus. The data were adjusted for age and gender. Results: The association of metabolic diseases on mortality was observed. Diabetes had a higher percentage of lethality 18,4%. When cardiovascular disease and diabetes were combined, the fatality rate rose to 31,5%; the combination of cardiovascular diseases, with hypertension and diabetes was the highest percentage of lethality 38,7%. Obesity had the least incidence. Conclusions: Metabolic diseases in México are a public health problem that affected COVID-19 mortality. It is a priority to deal with preventive and effective public policies in favor of a healthy food consumption model, in line with the nutritional needs of the population(AU)


Subject(s)
Humans , Male , Female , Cardiovascular Diseases/etiology , Diabetes Mellitus , Eating , COVID-19/mortality , Metabolic Diseases/complications , Metabolic Diseases/mortality , Obesity/physiopathology , Dietary Fats, Unsaturated , Epidemiology , Industrialized Foods , Pandemics , Hypertension
4.
Diagn. tratamento ; 26(2): 58-64, abr.-jun. 2021. graf, tab
Article in Portuguese | LILACS | ID: biblio-1280725

ABSTRACT

Contexto: A tontura é um sintoma de alta prevalência e as labirintopatias de causas metabólicas destacam-se como uma das mais frequentes em nosso meio. Distúrbios do metabolismo glicêmico, disfunções tireoidianas e dislipidemias são as principais. Objetivos: Os objetivos deste estudo são descrever a porcentagem das principais disfunções metabólicas nos pacientes com vertigem e revisar os métodos diagnósticos. Desenho e local: Estudo observacional de pacientes atendidos no setor de Otoneurologia do Instituto Penido Burnier. Métodos: Avaliação de 506 pacientes com vertigem por meio da análise do hormônio tireoestimulante, glicemia de jejum, hemoglobina glicada, insulina de jejum, curvas glicoinsulinêmica de três horas, colesterol total e suas frações (lipoproteína de alta densidade [HDL] e lipoproteína de baixa densidade [LDL]) e triglicerídeos. Foi feita a comparação entre os sexos e com os dados encontrados na população geral. Resultados: Níveis de HDL, triglicerídeos e glicemia de jejum foram mais alterados no sexo masculino e o colesterol total foi mais elevado no sexo feminino. A elevação do HOMA (homeostatic model assessment) foi a alteração mais significante encontrada no grupo em estudo comparando com a população geral, entretanto as curvas glicoinsulinêmicas mostraram mais alterações em comparação ao HOMA. Discussão: A análise do HOMA e da curva glicoinsulinêmica mostrou que a porcentagem de alteração é diferente entre os métodos, não havendo concordância entre eles. O HOMA não substitui as curvas na investigação dos pacientes com vertigem e suspeita de distúrbios do metabolismo glicêmico. Conclusão: É alta a porcentagem das disfunções metabólicas na população com vertigem, justificando a investigação laboratorial neste grupo de pacientes.


Subject(s)
Humans , Male , Female , Vertigo , Diabetes Mellitus , Observational Study , Glucose , Ear, Inner , Metabolic Diseases
5.
Más Vita ; 3(2): 40-48, jun 2021.
Article in Spanish | LILACS, LIVECS | ID: biblio-1253892

ABSTRACT

La diabetes es una enfermedad que afecta a la población mundial, y los adultos mayores son los más propenso a padecerla, como consecuencia a los niveles de estrés y malos hábitos alimenticios que llevaron a lo largo de su vida productiva. Es por ello, que el: Objetivo de esta investigación es, describir los factores asociados al autocuidado de la salud en los pacientes diabéticos. Materiales y métodos: Investigación documental. Se incluyeron estudios de cohortes que analizaron diagnóstico y tratamiento oportuno en el autocuidado de pacientes diabéticos en bases de datos electrónicas, como lo son Porta Scielo, PubMed, Medline PLUS, Embase, Scopus y Web of Science, del 2015 al 2020. Las medidas de autocuidado son habilidades que los individuos practican para el mantenimiento de su salud, sobre todo cuando hay una patología de base que ponga en riesgo el estado de salud y el bienestar en general. Resultado: La diabetes es una enfermedad complicada, requiere vigilancia constante, conocimiento de la enfermedad y del apoyo de varios especialistas en salud, la mayor parte del cuidado y control debe prevenir del paciente mismo. Es importante que los pacientes no solo perciban los daños o la severidad de la ausencia de autocuidado, lo que puede influir en el adecuado control de la diabetes mellitus, sino que se le proporcione mediante la educación para la salud, estrategias que faciliten en ellos el aprendizaje de habilidades que le permitan percibir los beneficios de la adopción de estilos de vida saludables. Conclusiones: el equipo básico de salud desempeña un rol importante en la realización de acciones que faciliten el autocuidado en los pacientes diabéticos, lo que puede constituir una vía para que las personas tomen decisiones serias respecto al mantenimiento de un adecuado estado de su salud. Por ende, es necesario que se realicen programas que desarrollen el ajuste adecuado de expectativas, objetivos definidos, el manejo adecuado del refuerzo, el incremento del sentimiento de autoeficacia, el autocontrol, y que brinden alternativas que favorezcan un autocuidado óptimo(AU)


Diabetes is a disease that affects the world population, and older adults are the most prone to suffer from it, as a consequence of the levels of stress and poor eating habits that they led throughout their productive lives. That is why the: Objective of this research is to describe the factors associated with self-care of health in diabetic patients. Materials and methods: Documentary research. Cohort studies that analyzed diagnosis and timely treatment in the self-care of diabetic patients were included in electronic databases, such as Porta Scielo, PubMed, Medline PLUS, Embase, Scopus and Web of Science, from 2015 to 2020. The measures of Self-care are skills that individuals practice to maintain their health, especially when there is an underlying pathology that puts the state of health and well-being in general at risk. Result: Diabetes is a complicated disease, it requires constant vigilance, knowledge of the disease and the support of various health specialists, most of the care and control must be prevented by the patient himself. It is important that patients not only perceive the damage or the severity of the absence of self-care, which can influence the adequate control of diabetes mellitus, but that it is provided through health education, strategies that facilitate in them the learning skills that allow you to perceive the benefits of adopting healthy lifestyles. Conclusions: the basic health team plays an important role in carrying out actions that facilitate self-care in diabetic patients, which can constitute a way for people to make serious decisions regarding the maintenance of an adequate state of their health. Therefore, it is necessary to carry out programs that develop the adequate adjustment of expectations, defined objectives, the adequate management of reinforcement, the increase of the feeling of self-efficacy, self-control, and that provide alternatives that favor a more optimal self-care(AU)


Subject(s)
Humans , Male , Female , Self Care , Diabetes Mellitus , Endocrine System , Metabolic Diseases , Public Health , Risk Factors , Feeding Behavior
7.
Arq. bras. med. vet. zootec. (Online) ; 73(3): 639-646, May-June 2021. tab
Article in English | LILACS, VETINDEX | ID: biblio-1278369

ABSTRACT

This study aimed to determine the impact of different post-partum disorders on milk yield and composition. One hundred and fifteen Holstein cows from a commercial dairy farm located in the state of Rio Grande do Sul in southern Brazil were monitored up to 62 days post-partum. During this period, body condition score evaluation and animal clinical examination were conducted. Percentages of fat, protein, and lactose, as well as somatic cells score, were determined in milk samples. The AST activity and concentrations of NEFA, calcium, and BHBA, were analyzed in blood samples. The occurrence of clinical disorders was identified in 30 (26%) cows. Subclinical disorders were identified in 64 (56%) cows. Only 21 (18%) cows did not suffer any kind of disorder within the studied period. In this study, no significant differences were found in milk production, protein, and somatic cell count in clinical, subclinical, and healthy cows. Milk fat and the fat: protein quotient (F:P) were higher in cows with clinical disorders and the 6 to 21 days in milk, and lactose were lower in cows with clinical disorders and the 22 to 42 days in milk (P<0.05).(AU)


O objetivo deste estudo foi determinar o impacto de diferentes distúrbios após o parto na produção de leite e em sua composição. Cento e quinze vacas Holandesas de uma fazenda de gado leiteiro, localizada em estado da região Sul do Brasil, foram monitoradas até 62 dias após o parto. Durante esse período, foram realizadas avaliações do escore de condição corporal e exame clínico nos animais. As porcentagens de gordura, proteína e lactose, bem como o escore de células somáticas, foram determinadas nas amostras de leite. A atividade do AST e as concentrações de NEFA, cálcio e BHBA foram analisadas em amostras de sangue. A ocorrência de distúrbios clínicos foi identificada em 30 (26%) vacas, os distúrbios subclínicos foram identificados em 64 (56%) vacas. Apenas 21 (18%) vacas não sofreram nenhum tipo de distúrbio ao longo do período estudado. Neste estudo, não foram encontradas diferenças significativas na produção do leite, proteína e na contagem de células somáticas em vacas com doenças clínicas, subclínicas e saudáveis. No leite, a gordura e o quociente gordura e proteína (G:P) foram maiores em vacas com doença clínica no período de seis a 21 dias de lactação, e a lactose foi menor em vacas com doença clínica no período de 22 a 42 dias de lactação (P<0,05).(AU)


Subject(s)
Animals , Female , Cattle , Milk/chemistry , Postpartum Period , Metabolic Diseases/veterinary , Metabolism
8.
Vive (El Alto) ; 4(10): 53-63, abr. 2021. ilus.
Article in Spanish | LILACS | ID: biblio-1292678

ABSTRACT

La diabetes es una de las principales enfermedades metabólicas en la cual los niveles de glucosa se ven afectados debido a que el cuerpo no produce insulina suficiente, para controlar la glucosa proveniente de los alimentos, lo que deriva o desencadena en los distintos tipos de diabetes, como la diabetes mellitus tipo 1 (DM1) y la diabetes mellitus tipo 2 (DM2). OBJETIVO: determinar la prevalencia de diabetes y factores de riesgo en enfermedades discapacitantes METODOLOGIA: el trabajo de investigación tuvo un alcance descriptivo, corte transversal y un enfoque cuantitativo. Se utilizó el instrumento RFT5-33 como principal material de apoyo para la recolección de datos. RESULTADOS: se determinó que la prevalencia de diabetes fue de 23,6% dejando como muestra 172 familias, de las cuales se observó como factores de riesgo que el 70,6% realiza una escasa actividad física; el consumo de alcohol representa el 14,1% y en base a la alimentación se constató que el 14% se alimenta menos de 3 veces al día y el 15,1% no desayunan. CONCLUSION: los factores de riesgo que más afectaron a la comunidad San Eduardo fueron el sedentarismo, consumo de alcohol y mala nutrición.(AU)


Diabetes is one of the major metabolic diseases level are affected because the body does not produce enough insulin to control glucose from food, which derives or triggers different types of diabetes such as one or two. OBJECTIVE: determine the prevalence of diabetes and risk factors in disabled diseases. METHODOLOGY: the research work had a descriptive scope, nonexperimental design and a quantitative approach. The RFT 5-33 instrument was used as the main supporting material for data collection. RESULTS: the prevalence of diabetes was determined in 23.6%, leaving 172 families, of which 70.6% were observed as rick factors performing low physical activity; alcohol consumption was 14.1% and 14% were found to be fed less than 3 times a day and 15.1% were not eating breakfast. CONCLUSION: the risk factors that most affected the San Eduardo community were sedentarism, alcohol consumption, and poor nutrition.(AU)


O diabetes é uma das principais doenças metabólicas em que os níveis de glicose são afetados porque o corpo não produz insulina suficiente para controlar a glicose dos alimentos, o que leva ou desencadeia diferentes tipos de diabetes, como diabetes mellitus tipo 1 (DM1) e diabetes tipo 2 mellitus (DM2). OBJETIVO: determinar a prevalência de diabetes e os fatores de risco em doenças incapacitantes METODOLOGIA: o trabalho de pesquisa teve um escopo descritivo, transversal e com abordagem quantitativa. O instrumento RFT5-33 foi utilizado como principal material de apoio para a coleta de dados. RESULTADOS: constatou-se que a prevalência de diabetes foi de 23,6%, deixando como amostra 172 famílias, das quais se observou como fatores de risco que 70,6% realizam pouca atividade física; O consumo de álcool representa 14,1% e com base na alimentação, verificou-se que 14% comem menos de 3 vezes ao dia e 15,1% não tomam café da manhã. Conclusão: Os fatores de risco que mais afetaram a comunidade San Eduardo foram o sedentarismo, o consumo de álcool e a má alimentação. (AU)


Subject(s)
Humans , Diabetes Mellitus, Type 2 , Metabolic Diseases , Cross-Sectional Studies , Sedentary Behavior
9.
Rev. cuba. enferm ; 37(1): e3536, 2021. tab
Article in Spanish | LILACS, BDENF, CUMED | ID: biblio-1341376

ABSTRACT

Introducción: La diabetes mellitus es una enfermedad metabólica que afecta a la población y requiere la evaluación de la calidad de vida para la formulación de estrategias de atención específicas y así minimizar o prevenir su deterioro. Objetivo: Evaluar la calidad de vida de personas con diabetes mellitus monitoreadas por la Unidad Básica de Salud. Métodos: Estudio transversal realizado con 82 diabéticos en una Unidad Básica de Salud. Se utilizaron cuestionarios que contenían variables sociodemográficas y clínicas y las áreas clínica y Problem Areas in Diabetes para la evaluación evaluar de la calidad de vida. En el análisis de datos, se utilizaron la prueba de Kruskal-Wallis, la prueba U de Mann-Whitney, la prueba t de Student y el analysis of variance. La mayoría de los participantes fueron mujeres, ancianas, casadas, con educación primaria completa, morenas, jubiladas, con su propio hogar, con un ingreso familiar de hasta un salario mínimo, diabéticos tipo 2, no fumadores, que usan antidiabéticos orales como una forma de tratamiento, sedentarios, no alcohólico, con dos comorbilidades asociadas a diabetes y entre seis y 10 años de diagnóstico. La puntuación total mostró un promedio de 32,36, lo que indica una buena calidad de vida para la mayoría de los participantes, y aquellos que sufren un impacto negativo presentan el factor emocional más afectado. Conclusión: Los datos obtenidos con este estudio permitirán la planificación de acciones específicas dirigidas a esta población para promover una mejor adherencia a las prácticas que influyen positivamente en la calidad de vida(AU)


Introdução: O Diabetes mellitus é uma doença metabólica que acomete a população, sendo necessária a avaliação da qualidade de vida para a formulação de estratégias de cuidado específicas para minimizar ou prevenir o seu comprometimento. Objetivo: Avaliar a qualidade de vida de pessoas com Diabetes Mellitus acompanhados pela Unidade Básica de Saúde. Métodos: Estudo transversal realizado com 82 diabéticos em uma Unidade Básica de Saúde. Utilizou- se questionários contendo variáveis sociodemográficas e clínicas e o Problem Areas in Diabetes para avaliação da qualidade de vida. Na análise dos dados, utilizaram-se os testes Kruskal-Wallis, U de Mann-Whitney, teste t de Student e Analysis of variance. Resultados: A maioria dos participantes são mulheres, idosas, casadas, com ensino fundamental completo, pardas, aposentadas, com casa própria, com renda familiar de até um salário mínimo, diabéticos tipo 2, não fumantes, que utilizam os antidiabéticos orais como forma de tratamento, sedentários, não etilistas, com duas comorbidades associadas ao diabetes e entre seis a 10 anos de diagnóstico. O escore total apresentou média de 32,36 , indicando boa qualidade de vida para a maioria dos participantes, e aqueles que sofrem impacto negativo apresentam o fator emocional como domínio mais acometido. Conclusão: Os dados obtidos com este estudo possibilitará o planejamento de ações específicas voltadas a essa população de modo a promover melhor adesão a práticas que influenciem positivamente na qualidade de vida(AU)


Introduction: Diabetes mellitus is a metabolic disease that affects population health and requires quality of life assessment to formulate specific care strategies to minimize or prevent its deterioration. Objective: To assess the quality of life of people with diabetes mellitus monitored by the basic health unit. Methods: Cross-sectional study carried out with 82 diabetic patients in a basic health unit. Questionnaires containing sociodemographic and clinical variables, as well as the problem areas in diabetes, were used to assess quality of life. In the data analysis, the Kruskal-Wallis test, the Mann-Whitney U test, the Student's t test and variance analysis were used. Results: Most of the participants were women, elderlies and had black skin. They were nonsmokers and nonalcoholic patients, had completed primary education and were retired. They had their own homes and a family income of up to a minimum wage. They had type 2 diabetes, apart from two comorbidities associated with diabetes, and between six and ten years of diagnosis. They used oral antidiabetics as a sedentary form of treatment. The total score showed an average of 32.36, which indicates a good quality of life for most of the participants, while those who suffered a negative impact had the emotional factor as the most affected domain. Conclusion: The data obtained from this study will allow planning specific actions targeted at this population to promote better adherence to practices that positively influence quality of life(AU)


Subject(s)
Humans , Quality of Life , Health Strategies , Diabetes Mellitus/diagnosis , Cross-Sectional Studies , Data Analysis , Metabolic Diseases/etiology
10.
Repert. med. cir ; 30(1): 7-12, 2021.
Article in English, Spanish | LILACS, COLNAL | ID: biblio-1281052

ABSTRACT

Introducción: la programación fetal ofrece nuevas perspectivas sobre el origen de las enfermedades cardiovasculares, relacionando su aparición con factores perinatales. Objetivo: exponer evidencia que vincule las alteraciones gestacionales con las enfermedades cardiovasculares en la vida adulta del feto. Metodología: búsqueda en las bases de datos EBSCO, COCHRANE, MEDLINE, PROQUEST y SciELO de los artículos de revisión e investigaciones originales en inglés publicados en los últimos diez años. Se utilizaron términos MeSH para búsqueda controlada y se evaluaron los estudios con STROBE y PRISMA según correspondía. Resultados: los hallazgos sugieren que nacer con menos de 2600 k guarda relación con diabetes mellitus (OR de 1.607 IC 95% 1.324-1.951), hipertensión arterial (OR de 1.15 IC 95% 1.043-1.288) y menor función endotelial (1.94+0.37 vs 2.68+0.41, p: 0.0001) en la adultez. La prematuridad se asocia con mayores presiones arteriales sistólicas (4.2 mmHg IC 95%; 2.8 - 5.7 p 0.001) y diastólicas (2.6 mmHg IC 95%; 1.2-4.0; p 0.001). Las alteraciones nutricionales maternas y la diabetes gestacional aumentan el riesgo de síndrome metabólico (OR 1.2 IC 95% 0.9-1.7) y sobrepeso en la edad escolar (OR 1.81 IC 95% 1.18 - 2.86). Conclusión: los resultados adversos en la gestación están relacionados con el desarrollo de enfermedades cardiovasculares en la vida adulta del feto expuesto.


Introduction: fetal programming offers new perspectives on the origin of cardiovascular diseases, relating their appearance with perinatal factors. Objective: to show the evidence associating gestational alterations with cardiovascular diseases in the offspring in adult life. Methodology: an EBSCO, COCHRANE, MEDLINE, PROQUEST and SciELO databases search of original review and research articles published in English in the last ten years was conducted. MeSH terms were used to perform a controlled search. The studies were analyzed accordingly using the STROBE and PRISMA reporting guidelines. Results:The findings suggest that a birth weight of less than 2600 kg is related with diabetes mellitus (OR = 1.607, 95% CI 1.324 to 1.951), hypertension (OR = 1.15, 95% CI 1.043 to 1.288) and impaired endothelial function (1.94+0.37 vs 2.68+0.41, p: 0.0001) in adulthood. Prematurity is related with higher systolic blood pressure (4.2 mmHg 95% CI; 2.8 to 5.7 p 0.001) and diastolic blood pressure (2.6 mmHg 95% CI; 1.2 to 4.0; p 0.001). Maternal nutritional alterations and gestational diabetes increase the risk of metabolic syndrome (OR = 1.2 95% CI 0.9 to 1.7) and overweight in school-age (OR = 1.81 95% CI 1.18 to 2.86). Conclusion: adverse results during pregnancy are related with the development of cardiovascular diseases in the exposed fetus in adult life.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Child, Preschool , Child , Adolescent , Adult , Cardiovascular Diseases/etiology , Fetal Development , Metabolic Diseases/etiology , Birth Weight , Nutritional Status , Diabetes, Gestational , Metabolic Syndrome/complications , Heart Disease Risk Factors , Obstetric Labor, Premature
11.
Rev. Hosp. Clin. Univ. Chile ; 32(3): 221-232, 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1348564

ABSTRACT

Sedentary behavior is spreading among society, especially since the rise of technology and progress. The sedentary lifestyle habits are being transmitted to young people, who increase the time they spend in sedentary activities like video games or TV. It has been demonstrated that both sedentary behavior and physical inactivity have negative cardiometabolic consequences for the health, and they become a serious problem for public health, as it has been claimed in several studies and by scientific statements. This review intent to make a call of attention to this problem that will have profound impact in the near future in many countries in Latin America. (AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Risk Factors , Sedentary Behavior/ethnology , Cardiovascular Diseases/prevention & control , Metabolic Diseases/prevention & control
12.
Ciencia Tecnología y Salud ; 8(2): 202-210, 2021. il 27 c
Article in Spanish | LILACS-Express | LILACS, LIGCSA, DIGIUSAC | ID: biblio-1353113

ABSTRACT

La medición de las desigualdades en salud al interior de los países de ingresos bajos y medios es necesaria para la planificación, monitoreo y evaluación de intervenciones de salud pública, especialmente para problemas que contribuyen altamente a la carga de enfermedad, como las enfermedades cardiometabólicas. El objetivo de este estudio fue caracterizar los patrones de desigualdad de las tasas de mortalidad para las principales causas cardiometabólicas en Guatemala. Se usó datos del Censo Nacional de Población, y estadísticas oficiales de de-función de 2018 para calcular tasas crudas de mortalidad para diabetes (DM), infarto agudo de miocardio (IAM), y accidente cerebrovascular (ACV). Se calcularon indicadores simples y complejos de desigualdad absoluta y relativa (diferencia, razón, índice de pendiente, índice de concentración, distancia de la media, índice de Theil, riesgo atribuible poblacional, y porcentaje de riesgo atribuible poblacional) para seis dimensiones de desigualdad: sexo, pueblo de pertenencia, nivel educativo, tipo de ocupación, departamento y municipio. Se documentaron 6,445 muertes por DM, 5,761 por IAM, y 3,218 por ACV. Los indicadores mostraron marcadas desigualdades para las seis dimensiones estudiadas. El patrón de desigualdad predominante para sexo, pueblo de pertenencia y departamento fue de privación masiva. Para nivel educativo y ocupación predominó un patrón de incrementos escalonados. Se identificó exclusión marginal superpuesta en nivel educativo, ocupación y municipio. Se concluye que los patrones de desigualdad de las tasas de mortalidad para estas tres enfermedades sugieren la superposición de patrones de privación masiva, incrementos escalonados, y exclusión marginal.


Measuring health inequalities within low- and middle-income countries is needed for planning, monitoring, and evaluation of public health interventions, especially for problems that represent a high burden of disease, like cardio metabolic diseases. The goal of this study was to characterize inequality patterns in mortality rates from cardio metabolic causes in Guatemala. Data from the 2018 National Population Census, and official vital statistics were used to estimate crude mortality rates for diabetes (DM), acute myocardial infarction (IAM), and stroke (ACV). Simple and complex indicators of absolute and relative inequality (difference, ratio, slope index, concentration index, distance from the mean, Theil index, population attributable risk, and percentage of popula-tion attributable risk) were calculated for six dimensions of inequality: sex, race/ethnicity, education level, type of occupation, department, and municipality. A total of 6,445 DM deaths, 5,761 IAM deaths, and 3,218 ACV deaths were documented. Indicators showed marked inequalities for the six dimensions studied. Massive deprivation was the predominant inequality pattern for sex, race/ethnicity, and department. Staggered increments were iden-tified for education level and type of occupation. Overlapping marginal exclusion was found for education level, occupation, and municipality. We conclude that inequality patterns found for the three causes of death suggest overlapping patterns of mass deprivation, staggered increments, and marginal exclusion.


Subject(s)
Humans , Male , Female , Cause of Death , Stroke/mortality , Metabolic Diseases/mortality , Socioeconomic Factors , Ethnic Groups , Vital Statistics , Health Status Indicators , Guatemala/epidemiology , Occupations/economics
13.
Acta Physiologica Sinica ; (6): 342-352, 2021.
Article in Chinese | WPRIM | ID: wpr-878262

ABSTRACT

Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.


Subject(s)
Exercise Therapy , Humans , Insulin-Like Growth Factor I , Liver , Metabolic Diseases/therapy , Muscle, Skeletal
14.
Chinese Medical Journal ; (24): 1276-1285, 2021.
Article in English | WPRIM | ID: wpr-878166

ABSTRACT

Excessive consumption of fructose, the sweetest of all naturally occurring carbohydrates, has been linked to worldwide epidemics of metabolic diseases in humans, and it is considered an independent risk factor for cardiovascular diseases. We provide an overview about the features of fructose metabolism, as well as potential mechanisms by which excessive fructose intake is associated with the pathogenesis of metabolic diseases both in humans and rodents. To accomplish this aim, we focus on illuminating the cellular and molecular mechanisms of fructose metabolism as well as its signaling effects on metabolic and cardiovascular homeostasis in health and disease, highlighting the role of carbohydrate-responsive element-binding protein in regulating fructose metabolism.


Subject(s)
Fructose/adverse effects , Homeostasis , Humans , Metabolic Diseases/etiology
15.
Article in Chinese | WPRIM | ID: wpr-879882

ABSTRACT

OBJECTIVE@#To study the efficacy and safety of continuous renal replacement therapy (CRRT) in the treatment of neonates with inherited metabolic diseases and hyperammonemia.@*METHODS@#A retrospective analysis was performed on the medical records of neonates with inherited metabolic diseases and hyperammonemia who were hospitalized and underwent CRRT in the Department of Neonatology, Hunan Children's Hospital, from September 2016 to March 2020, including general conditions, clinical indices, laboratory markers, and adverse reactions.@*RESULTS@#A total of 11 neonates were enrolled, with 7 boys (64%) and 4 girls (36%). The neonates had a mean gestational age of (38.9±0.8) weeks, a mean body weight of (3 091±266) g on admission, and an age of (5.7±2.0) days at the time of CRRT. The main clinical manifestations were vomiting (100%), convulsions (100%), and coma (55%), and the main primary disease was urea cycle disorder (55%). The mean duration of CRRT was (44±14) hours, the medium duration of coma before CRRT was 2 hours, and the total duration of coma was 10 hours. The patients had a mean hospital stay of (18±10) days and a survival rate of 73%, and 2 survivors had epilepsy. After treatment, all patients had significant reductions in blood ammonia, lactic acid, and K@*CONCLUSIONS@#CRRT is safe and effective in the treatment of neonates with inherited metabolic diseases and hyperammonemia.


Subject(s)
Acute Kidney Injury , Child , Continuous Renal Replacement Therapy , Female , Humans , Hyperammonemia/therapy , Infant , Infant, Newborn , Length of Stay , Male , Metabolic Diseases/therapy , Retrospective Studies
16.
Int. j. morphol ; 38(6): 1645-1650, Dec. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1134492

ABSTRACT

RESUMEN: El aumento sostenido en la prevalencia de sobrepeso y obesidad en niños, niñas y adolescentes, causa alarma en la comunidad científica, que observa incrementos importantes en las enfermerdades asociadas a Síndrome Metabólico (SM), en la vida adulta. Chile presenta un 75 % con sobrepeso y obesidad en la población adulta y un 50,9 % en la población estudiantil, con un 66,2 % de sedentarismo. Los objetivos de este trabajo fueron determinar los perfiles antropométricos y su asociación a riesgo metabólico en adolescentes de colegio particular subvencionado de Arica-Chile. El total de los alumnos de enseñanza media, n= 810 (mujeres n= 437 y hombres n= 373), fueron evaluados según: peso, talla, perímetro de cintura, índice cintura-talla (ICT), índice de masa corporal (IMC). A todos ellos se les calculó el riesgo metabólico según protocolos de Ashwell & Gibson (2016) y el IMC según fórmula de Quetelet. Los datos fueron analizados en estadístico para tendencia central, dispersión y porcentajes. Para correlación se utilizó test de Pearson (r>0,5). Los resultados muestran que un 44,1 % de las mujeres y un 37,2 % de los hombres presentan sobrepeso y obesidad. El riesgo metabólico general de la población en estudio fue de 24,6 % (24,7 % y 24,4 % en mujeres y hombres respectivamente). Se observó una alta correlación entre PC / ICT (r= 0,92), IMC / ICT (r= 0,86) y Peso / PC (r= 0,87). Se concluye que las y los adolescentes presentan valores antropométricos alterados que indican altos índices de riesgos metabólicos. Los parámetros más alterados se observan en el segundo año de enseñanza media con porcentajes de sobrepeso y obesidad de 49,1 % en las mujeres versus 33,8 % en los hombres. Independientemente, los hombres presentaron mejores índices morfométricos que las mujeres. Se observaron altas correlaciones (r> 0,5) en todos los parámetros en estudio, asociados a riesgo metabólico. Se sugiere enfocar las intervenciones educativas según sello de vida saludable, incentivando la actividad física y mejorar los hábitos alimenticios en las y los adolescentes escolarizados.


SUMMARY: The sustained increase in the prevalence of overweight and obesity in children and adolescents causes alarm in the scientific community, who observe significant increases in diseases associated with Metabolic Syndrome (MS), in adult life. Chile presents 75 % with overweight and obesity in the adult population and 50.9 % in the student population and with 66.2 % of sedentary lifestyle. The objectives of this work were to determine the anthropometric profiles and their association with metabolic risk in adolescents from a subsidized private school in Arica-Chile. The total of high school students, n = 810 (women n = 437 and men n = 373), were evaluated according to: weight, height, waist circumference, waist-height index (WHI), body mass index (BMI). Metabolic risk was calculated for all of them according to Ashwell & Gibson protocols and BMI according to Quetelet's formula. The data were analyzed in statistics for central tendency, dispersion, and percentages. Pearson test (r> 0.5) was used for correlation. The results show that 44.1 % of women and 37.2 % of men are overweight and obese. The general metabolic risk of the study population was 24.6 % (24.7 % and 24.4 % in women and men, respectively). A high correlation was observed between WC / WHI (r = 0.92), BMI / WHI (r = 0.86) and Weight / WC (r = 0.87). It is concluded that adolescents present altered anthropometric values that indicate high rates of metabolic risks. The most altered parameters were observed in the second year of secondary education with percentages of overweight and obesity of 49.1 % in women versus 33.8 % in men. Regardless, males presented better morphometric indices than females. High correlations (r> 0.5) were observed in all the parameters under study, associated with metabolic risk. It is suggested to focus educational interventions according to the seal of healthy living, encouraging physical activity and improving eating habits in school adolescents.


Subject(s)
Humans , Male , Female , Adolescent , Anthropometry , Risk Assessment/methods , Sedentary Behavior , Metabolic Diseases/etiology , Body Mass Index , Chile , Cross-Sectional Studies , Risk Factors , Education, Primary and Secondary , Overweight , Obesity
17.
Rev. bras. oftalmol ; 79(5): 336-339, set.-out. 2020. tab, graf
Article in English | LILACS | ID: biblio-1137986

ABSTRACT

Abstract Sclerochoroidal calcifications (SC) are a rare and benign ocular condition characterized by yellow-white irregular subretinal lesions usually found in the supero-temporal arcade of the midperipheral fundus in middle-aged elderly men. We present a clinical case of a 79- year-old patient who during a fundus examination presented raised whitish nodules in the supero-temporal arcade in the right eye. After performing optical coherence tomography, ultrasound, ocular computed tomography and laboratory analysis, she was diagnosed with idiopathic sclerochoroidal calcifications The pathogenesis of sclerochoroidal calcifications remains unclear but systemic conditions should be discarded. It is important to distinguish sclerochoroidal calcifications from other conditions such as tumors.


Resumo Calcificações esclerocoroidais (SC) são uma condição ocular rara e benigna caracterizada por lesões sub-retinianas irregulares amarelo-brancas, geralmente encontradas na arcada superotemporal do fundo médio-periférico em homens idosos de meia-idade. Apresentamos um caso clínico de uma paciente de 79 anos que durante exame de fundo apresentou nódulos esbranquiçados elevados na arcada superotemporal do olho direito. Após realizar tomografia de coerência óptica, ultra-sonografia, tomografia computadorizada ocular e análise laboratorial, ela foi diagnosticada com calcificações esclerocoroidais idiopáticas A patogênese das calcificações esclerocoroidais permanece incerta, mas as condições sistêmicas devem ser descartadas. É importante distinguir calcificações esclerocoroidais de outras condições, como tumores.


Subject(s)
Humans , Female , Aged , Calcinosis/diagnostic imaging , Scleral Diseases/diagnostic imaging , Choroid Diseases/diagnostic imaging , Tomography, X-Ray Computed/methods , Ultrasonography/methods , Clinical Laboratory Techniques/methods , Tomography, Optical Coherence/methods , Diagnosis, Differential , Metabolic Diseases
18.
Rev. Bras. Saúde Mater. Infant. (Online) ; 20(3): 819-827, July-Sept. 2020. tab, graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1136455

ABSTRACT

Abstract Objectives: to identify trendand factors associated with adverse birth weight. Methods: cross-sectional design. The analysis uses the 2009-2015 Uruguay Perinatal Computer Systemdata on 303,625 newborns. Results: the prevalence of macrosomia (> 3,999g) has increased from 7.0% to 8.4%. The prevalence of low birth weight (LBW) (< 2,500g) decreased, standing at 6.6% in the last year. The factors that determines more possibilities of LBW were preeclampsia (OR = 4.80; CI95%= 4.57-5.05), inadequate controls (OR = 2.29; CI95%= 2.20-2.39), shorter duration of pregnancy (OR = 2.52; CI95%= 2.50-2.55), previous hypertension (OR = 2.11; CI95%= 1.96-2.27), hypertensive disease of pregnancy (OR = 1.82; CI95%= 1.74-1.90), low prematernal maternal weight (OR = 1.65; CI95%= 1.58-1.74). Macrosomia was associated with type 1 diabetes (OR = 2.21; CI95%= 1.86-2.61), Type 2 or Gestational (OR = 1.78; CI95%= 1.70-1.87), obesity maternal (OR = 2.33; CI95%= 2.24-2.43) and longer gestation duration (OR = 2.62; CI95%= 2.53-2.72). Conclusions: the LBW decreases while the macrosomia increases. The health and nutritional status of women at the beginning of pregnancy, pathologies of the last trimester, smoking, shorter duration of pregnancy and inadequate controls are associated with BPN. Overweight, obesity and metabolic diseases determine macrosomia.


Resumen Objetivos: identificar tendencia y factores asociados al peso al nacer adverso. Métodos: diseño transversal, se analizaron nacimientos entre 2009-2015. El análisis utilizó el Sistema Informático Perinatal de Uruguay, de 2009-2015, datos de 303.625 recién nacidos. Resultados: la prevalencia de macrosomía (>3.999g) aumentó de 7% a 8,4%. La prevalencia de bajo peso al nacer (BPN) (<2.500g) disminuyó situándose en 6,6% en el último año. Los factores que determinaron mayores posibilidades de BPN fueron preeclampsia (OR=4,80; IC95%= 4,57-5,05), inadecuados controles (OR = 2,29; IC95%= 2,20-2,39), menor duración de la gestación (OR = 2,52; IC95%= 2,50-2,55), hipertensión arterial previa (OR = 2,11; IC95%= 1,96-2,27), enfermedad hipertensiva del embarazo (OR = 1,82; IC95%= 1,74-1,90), bajo peso materno pregestacional (OR = 1,65; IC95%= 1,58-1,74). Macrosomía se asoció con diabetes tipo 1 (OR = 2,21; IC95%= 1,86-2,61), tipo 2 o Gestacional (OR = 1,78; IC95%= 1,70-1,87), obesidad materna (OR = 2,33; IC95%= 2,242,43) y duración de gestación (OR = 2,62; IC95%= 2,53-2,72). Conclusiones: existe una tendencia a disminución del BPNy aumento de la macrosomía. La salud y estado nutricional de la mujer al inicio de la gestación, patologías del último trimestre, tabaquismo, menor duración de la gestación e inadecuados controles se asocian a BPN. El sobrepeso, la obesidad y enfermedades metabólicas determinan macrosomía.


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Uruguay/epidemiology , Birth Weight , Fetal Macrosomia/epidemiology , Infant, Low Birth Weight , Risk Factors , Overweight , Obesity, Maternal , Metabolic Diseases
19.
Rev. chil. obstet. ginecol. (En línea) ; 85(4): 408-419, ago. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1138639

ABSTRACT

Las enfermedades cardiovasculares representan la mayor causa de morbimortalidad a nivel mundial. Si bien presenta un descenso en la población general, en las mujeres tiende a mantenerse estable la prevalencia de enfermedad coronaria. Varios factores propios de la mujer predisponen a que esto ocurra, incluyendo el embarazo, mediado tanto por los cambios hematológicos y cardiovasculares característicos de la gestación; como por patologías asociadas, principalmente trastornos hipertensivos del embarazo y diabetes gestacional. Su presencia se ha asociado fuertemente a la aparición a futuro de otras patologías de alto riesgo cardiovascular como hipertensión crónica, dislipidemia y diabetes mellitus. Dado el impacto que esto representa, se hace imperante la identificación de grupos de alto riesgo y la implementación de medidas preventivas, así como de diagnóstico precoz y tratamientos adecuados con el fin de disminuir complicaciones materno-fetales en las etapas perinatal y posparto.


Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Although there is a decrease in general population, the prevalence of coronary heart disease remains stable in women. Several factors typical of womenkind predispose to cardiovascular disease, including pregnancy, mediated by hematological and cardiovascular changes characteristic of it; and by associated pathologies, mainly hypertensive disorders and diabetes. The presence of these diseases has been strongly associated with future presence of other conditions of high cardiovascular risk such as chronic hypertension, dyslipidemia and diabetes mellitus. Given this impact, the identification of high-risk groups and the implementation of preventive measures, as well as early diagnosis and adequate treatment in order to reduce both maternal and fetal complications in perinatal and postpartum stages becomes imperative.


Subject(s)
Humans , Female , Pregnancy , Pre-Eclampsia , Pregnancy Complications, Cardiovascular/etiology , Cardiovascular Diseases/complications , Diabetes, Gestational , Hypertension/complications , Pre-Eclampsia/diagnosis , Pre-Eclampsia/therapy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/therapy , Cardiovascular System/physiopathology , Risk Factors , Diabetes, Gestational/diagnosis , Diabetes, Gestational/therapy , Metabolic Diseases
20.
Más Vita ; 2(2): 21-30, jun. 2020. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1284100

ABSTRACT

La diabetes tipo 2 es una enfermedad relevante debido al aumento de su prevalencia en mayores de 50 años. Objetivo: Determinar la participación familiar en la prevención de complicaciones de pacientes con diabetes tipo 2 que ingresan en la Unidad de Cuidados Intensivos - Hospital General IESS Mila-gro, enero a junio del 2019. Metodología: tuvo un enfoque cuantitativo, descriptivo-deductivo, no experimental de corte transversal. Se diseñó un formulario con 13 preguntas que responde a los objetivos del estudio. Del universo de 210 pacientes ingresados se tomó una muestra conformada por 68 pacientes con sus respectivos familiares, seleccionada mediante muestreo no probabilístico, de los cuales el 64.7% pertenecen a género masculino, siendo las edades más afectadas los de 61 a 80 años, que viven en la zona rural (33.82%). Resultados: demostraron que el desconocimiento de los familiares sobre la enfermedad y sus complicaciones es uno de los factores más relevantes, con el 85.29%; el tiempo de evolución de la enfermedad es de seis a ocho años (52.94%); la participación en la administración de medicamentos es mayoritariamente proporcionada por su cónyuge (38,24%); la situación laboral es la limitante principal en el cuidado del paciente (55.88%), siendo el nivel de de-pendencia moderada-severa el principal problema (44.12%); el incumplimiento de las indicaciones médicas representada por el 54.41%, presentando la hiperglicemia (44.12%), y la nefropatía (65.45%), la hipertensión (43.75%) como las complicaciones más relevantes; el índice de mortalidad es de 27.94%. Conclusión: Se encontró que la participación familiar in-fluye de manera significativa en el cuida-do de estos pacientes, ya que permiten prevenir las complicaciones por diabetes tipo 2, como parte de las estrategias de salud pública para enfrentar las enfermedades crónicas no transmisibles(AU)


Type 2 diabetes is a relevant disease due to the increase in its pre-valence in people over 50 years of age. Objective: To determine the family partici-pation in the prevention of complications in patients with type 2 diabetes admitted to the Intensive Care Unit - General Hos-pital IESS Milagro, January to June 2019. Methodology: it had a quantitative, des-criptive-deductive, non-experimental cross-sectional approach. A form with 13 questions in order to answers the objec-tives of the study, was designed. From the universe of 210 admitted patients, a sample was made up of 68 patients with their respective relatives, selected by means of non-probability sampling, of which 64.7% belong to the male gender, the most affected ages being those be-tween 61 and 80 years of age, who live in the rural area (33.82%). Results: they showed that the ignorance of the relatives about the disease and its complications is one of the most relevant factors, with 85.29%. The evolution time of the disease is six to eight years (52.94%). Your spou-se (38.24%), mostly provides participa-tion in the administration of medications. The labor situation is the main limitation in patient care (55.88%), with the level of moderate-severe dependency being the main problem (44.12%); non-complian-ce with medical indications represented by 54.41%, presenting hyperglycemia (44.12%), and kidney disease (65.45%), hypertension (43.75%) as the most rele-vant complications; the mortality rate is 27.94%. Conclusion: It was found that family participation significantly influences the care of these patients, since they allow preventing complications from type 2 diabetes, as part of public health strate-gies to deal with chronic non-communicable diseases(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/physiopathology , Family Relations , Intensive Care Units , Metabolic Diseases , Chronic Disease , Patient Comfort , Patient Care
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