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1.
Rev. Assoc. Med. Bras. (1992) ; 68(2): 250-255, Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365337

ABSTRACT

SUMMARY OBJECTIVE: The metabolic syndrome involves both metabolic and cardiovascular risk factors and is associated with cardiovascular mortality. Epicardial fat tissue plays a crucial role in deleterious effects of metabolic syndrome on the heart, including myocardial fibrosis. The fragmented QRS reflects heterogeneous depolarization of the myocardium and occurs as a result of fibrosis. Thus, we aimed to investigate whether there is an association between fragmented QRS and epicardial fat tissue in patients with metabolic syndrome. METHODS: This study enrolled 140 metabolic syndrome patients, of whom 35 patients with fragmented QRS (+) and 105 patients with fragmented QRS (−). The two groups were compared with respect to clinical, laboratory, electrocardiographic, and echocardiographic indexes. RESULTS: Fragmented QRS (+) patients had higher waist circumference, red cell distribution width, creatinine, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, QRS duration, and epicardial fat tissue compared with fragmented QRS (−) patients. Waist circumference, red cell distribution width, QRS duration, left ventricular end-systolic diameter, left atrium diameter, septal a velocity, and epicardial fat tissue were significantly associated with the presence of fragmented QRS. The QRS duration and epicardial fat tissue were independently associated with the presence of fragmented QRS on surface electrocardiographic in metabolic syndrome patients. CONCLUSIONS: Epicardial fat tissue and QRS duration were independently associated with the presence of fragmented QRS. Basic echocardiographic and electrocardiographic parameters might be used for the risk stratification in metabolic syndrome patients.


Subject(s)
Humans , Metabolic Syndrome/complications , Echocardiography , Adipose Tissue/diagnostic imaging , Electrocardiography/methods , Waist Circumference
2.
An. bras. dermatol ; 97(1): 28-36, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360088

ABSTRACT

Abstract Background: Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world's population and is linked to inflammatory skin diseases including vitiligo. Fatty AcidBinding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is closely associated with MetS. Objectives: To evaluate the serum level of FABP4 in vitiligo patients and its relation to MetS in the investigated cases. Methods: This case control study was conducted on 45 patients having non segmental vitiligo and 45 matched controls. Their lipid profile, blood glucose and serum FABP4 levels were measured. Results: There were significant elevations in FABP4 (p < 0.001), cholesterol (p < 0.001), triglycerides (p = 0.005), and glucose (fasting [p = 0.001] and 2 hours post prandial [p < 0.001]) levels in patients in comparison with controls. MetS was significantly more prevalent among vitiligo patients (p < 0.001) and associated with high FABP4 serum levels (p = 0.037). In vitiligo patients, there were significant positive correlations between FABP4 serum levels and triglycerides (p = 0.047), cholesterol (p = 0.001) and LDL (p = 0.001) levels and negative correlation regarding HDL level (p = 0.009). FABP4 level was a significantly good diagnostic test for early detection of vitiligo (p < 0.001). Study limitations: The small number of studied subjects. Conclusions: FABP4 may play an active role in the disease process of vitiligo that could be mediated through associated dyslipidemia and hyperglycemia. FABP4 may be a marker of vitiligo helping in its early diagnosis, but it does not appear to be useful for determining vitiligo severity, activity or associated MetS.


Subject(s)
Humans , Metabolic Syndrome , Fatty Acid-Binding Proteins/blood , Triglycerides , Vitiligo , Case-Control Studies
3.
Arq. bras. cardiol ; 118(1): 68-74, jan. 2022. tab
Article in English, Portuguese | LILACS | ID: biblio-1360106

ABSTRACT

Resumo Fundamento Apesar da grande proporção de octogenários com embolia pulmonar aguda, há pouca informação indicando a estratégia de manejo ideal, especialmente medidas terapêuticas, como a terapia lítica. Objetivos O número de pacientes idosos diagnosticados com embolia pulmonar aguda aumenta constantemente. Porém, o papel do tratamento trombolítico não está claramente definido entre os octogenários. Nosso objetivo é avaliar a efetividade da terapia lítica em pacientes octogenários diagnosticados com embolia pulmonar. Métodos Cento e quarenta e oito indivíduos (70,3% de mulheres, n=104) com mais de 80 anos foram incluídos no estudo. Os pacientes foram divididos em dois grupos: tratamento trombolítico versus não-trombolítico. As taxas de mortalidade hospitalar e episódios de sangramento foram definidos como desfechos do estudo. Valor de p <0,05 foi considerado como estatisticamente significativo. Resultados A mortalidade hospitalar reduziu significativamente no grupo trombolítico em comparação ao não-trombolítico (10,5% vs. 24,2%; p=0,03). Episódios de sangramento menores foram mais comuns no braço que recebeu o tratamento trombolítico, mas grandes hemorragias não diferiram entre os grupos (35,1% vs. 13,2%, p<0,01; 7% vs. 5,5% p=0,71, respectivamente). O escore de PESI alto (OR: 1,03 IC95%; 1,01-1,04 p<0,01), a terapia trombolítica (OR: 0,15 IC95%; 0,01-0,25, p< 0,01) e níveis altos de troponina (OR: 1,20 IC95%; 1,01-1,43, p=0,03) estiveram independentemente associados a taxas de mortalidade hospitalar na análise de regressão multivariada. Conclusão A terapia trombolítica esteve associada à mortalidade hospitalar reduzida em detrimento do aumento geral das complicações de sangramento em octogenários.


Abstract Background Despite the high proportion of octogenarians with acute pulmonary embolism, there is little information indicating the optimal management strategy, mainly therapeutic measures, such as lytic therapy. Objectives The number of elderly patients diagnosed with acute pulmonary embolism increases constantly. However, the role of thrombolytic treatment is not clearly defined among octogenarians. Our objective is to evaluate the effectiveness of lytic therapy in octogenarian patients diagnosed with pulmonary embolism. Methods One hundred and forty eight subjects (70.3% women, n=104) aged more than eighty years were included in the study. The patients were divided in two groups: thrombolytic versus non-thrombolytic treatment. In-hospital mortality rates and bleeding events were defined as study outcomes. P-value <0.05 was considered as statistical significance. Results In-hospital mortality decreased significantly in the thrombolytic group compared to the non-thrombolytic group (10.5% vs. 24.2% p=0.03). Minor bleeding events were more common in the arm that received thrombolytic treatment, but major hemorrhage did not differ between the groups (35.1% vs. 13.2%, p<0.01; 7% vs. 5.5% p=0.71, respectively). High PESI score (OR: 1.03 95%CI; 1.01-1.04 p<0.01), thrombolytic therapy (OR: 0.15 95%CI; 0.01-0.25, p< 0.01) and high troponin levels (OR: 1.20 95%CI; 1.01-1.43, p=0.03) were independently associated with in-hospital mortality rates in the multivariate regression analysis. Conclusion Thrombolytic therapy was associated with reduced in-hospital mortality at the expense of increased overall bleeding complications in octogenarians.


Subject(s)
Humans , Child , Adolescent , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Metabolic Syndrome/epidemiology , Pediatric Obesity/therapy , Body Composition , Weight Loss/physiology , Body Mass Index , Atrial Natriuretic Factor/metabolism
4.
Arq. bras. cardiol ; 118(1): 33-40, jan. 2022. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1360114

ABSTRACT

Resumo Fundamento A ação do peptídeo natriurético atrial (ANP) na natriurese, diurese e vasodilatação, resistência à insulina, fígado, rim e tecido adiposo pode contribuir para o desenvolvimento metabólico e cardiovascular saudável. Embora o nível circulante de ANP seja reduzido em pacientes com obesidade, sua resposta à perda de peso ainda é pouco explorada em populações pediátricas. Objetivo Avaliar os efeitos das variações do ANP em resposta à intervenção interdisciplinar para perda de peso na Síndrome Metabólica (SMet) e nos riscos cardiometabólicos em adolescentes com obesidade. Métodos 73 adolescentes com obesidade participaram de uma terapia interdisciplinar para perda de peso de 20 semanas, incluindo uma abordagem clínica, nutricional, psicológica e de exercícios físicos. A composição corporal, análises bioquímicas e pressão sanguínea foram avaliadas. A SMet foi classificada de acordo com a Federação Internacional de Diabetes (IDF) (2007). Após o tratamento, os voluntários foram divididos de acordo com os níveis de plasma do ANP aumento (n=31) ou ANP redução (n=19). Resultados Ambos os grupos apresentaram redução significativa de peso corporal, índice de massa corporal (IMC) e circunferências de cintura, pescoço e quadril (CC, CP e CQ, respectivamente), e aumento da massa livre de gordura (MLG). É interessante observar que houve uma redução significativa na gordura corporal, na razão de TG/HDL-c e na prevalência de SMet (de 23% para 6%) somente no grupo com ANP aumento. Conclusão Este estudo sugere que o aumento nos níveis séricos de ANP após a terapia para perda de peso pode estar associado a melhorias nos riscos cardiometabólicos e na prevalência reduzida de SMet em adolescentes com obesidade.


Abstract Background The action of atrial natriuretic peptide (ANP) on natriuresis, diuresis and vasodilatation, insulin resistance, liver, kidney, and adipose tissue may contribute to the healthy metabolic and cardiovascular development. Even though the circulating level of ANP is reduced in patients with obesity, its response to weight loss remains poorly explored in pediatric populations. Objective To evaluate the effects of ANP variations in response to interdisciplinary weight loss intervention on metabolic syndrome (MetS) and cardiometabolic risks in adolescents with obesity. Methods 73 adolescents with obesity attended a 20-week clinical interdisciplinary weight loss therapy including clinical, nutritional, psychological and exercise training approach. Body composition, biochemical analyses and blood pressure were evaluated. MetS was classified according to the International Diabetes Federation (IDF) (2007). After the treatment, volunteers were divided according to Increasing (n=31) or Decreasing (n=19) ANP plasma levels. Results Both groups present significant reduction of body weight, Body Mass Index (BMI), waist, neck and hip circumferences (WC, NC and HC, respectively) and increasing fat-free mass (FFM). Interestingly, a significant reduction in body fat, TG/HDL-c ratio and MetS prevalence (from 23% to 6%) was observed in the Increased ANP group only. Conclusion This study suggests that an increase in ANP serum levels after weight loss therapy could be associated with improvements in cardiometabolic risks and the reduced prevalence of MetS in adolescents with obesity.


Subject(s)
Humans , Child , Adolescent , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Metabolic Syndrome/epidemiology , Pediatric Obesity/therapy , Body Composition , Weight Loss/physiology , Body Mass Index , Atrial Natriuretic Factor/metabolism
5.
Texto & contexto enferm ; 31: e20210074, 2022. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1357483

ABSTRACT

ABSTRACT Objective: to validate an educational booklet for the promotion of knowledge about the prevention of Metabolic Syndrome in adolescents. Method: a time series quasi-experiment conducted in 2020 with 37 adolescents from five public schools belonging to the teaching state network of Picos, Piauí, Brazil. It was conducted in two phases: 1) development of a script of questions about the prevention of MS and its content validation by 17 experts; 2) quasi-experiment with reading of the booklet called "Síndrome Metabólica: Como me prevenir?" ("Metabolic Syndrome: How can I protect myself?", and assessment of the adolescents' knowledge through a script of questions before and after reading the booklet. To analyze content validity of the script of questions, the Content Validity Ratio was calculated (CVR>0.529). The McNemar test (p<0.05) was used to investigate the effect of the educational booklet on the adolescents' knowledge. The study was approved by the Research Ethics Committee of Universidade Federal do Piauí. Results: the script of question's overall CVR was 0.718, representing good content validation. Three assertions were removed (CVR>0.529). Regarding the adolescents' knowledge, 45.9% improved it, with no significant difference (p=0.067). Conclusion: the adolescents' knowledge was higher in almost half of the participants in the post-test, showing that reading the educational booklet favored knowledge about the prevention of Metabolic Syndrome.


RESUMEN Objetivo: validar el cuadernillo educativo para promover el conocimiento sobre la prevención del Síndrome Metabólico entre adolescentes. Método: cuasi experimento de series temporales realizado en 2020 con 37 adolescentes de cinco escuelas públicas pertenecientes a la red estatal de enseñanza de Picos, Piauí, Brasil. Se realizó en dos fases: 1) desarrollo del guion de preguntas sobre prevención del SM y su validación de contenido a cargo de 17 especialistas; 2) cuasiexperimento con lectura del cuadernillo "Síndrome Metabólica: Como me prevenir?" ("Síndrome Metabólico: ¿Cómo puedo protegerme?"), y evaluación del conocimiento de los adolescentes antes y después de la lectura a través del guion de preguntas. Para analizar la validez del contenido del guion de preguntas, se calculó la Relación de Validez de Contenido (Content Validity Ratio, CVR>0,529). Para investigar el efecto del cuadernillo educativo sobre el conocimiento de los adolescentes, se utilizó la prueba de McNemar (p<0,05). El estudio fue aprobado por el Comité de Ética e Investigación de la Universidade Federal do Piauí. Resultados: el CVR total del guion fue de 0,718, lo que representa buena validación del contenido del guion de preguntas. Se eliminaron tres afirmaciones (CVR>0,529). En relación con el conocimiento de los adolescentes, el 45,9% presentó mejoras, sin diferencias significativas (p=0,067). Conclusión: el conocimiento de los adolescentes fue superior en prácticamente la mitad de los participantes en el post-test, lo que demuestra que leer el cuadernillo educativo favoreció el conocimiento sobre la prevención del Síndrome Metabólico.


RESUMO Objetivo: validar a cartilha educativa para promoção do conhecimento sobre prevenção da Síndrome Metabólica em adolescentes. Método: quase experimento de séries temporais realizado em 2020 com 37 adolescentes de cinco escolas públicas da rede estadual de ensino de Picos-Piauí-Brasil. Foi realizado em duas fases: 1) desenvolvimento de roteiro de questões sobre prevenção da SM e sua validação de conteúdo por 17 especialistas; 2) quase-experimento com implementação de leitura da cartilha "Síndrome Metabólica: Como me prevenir?", e avaliação do conhecimento dos adolescentes pré e pós-leitura via roteiro de questões. Para análise da validade de conteúdo do roteiro de questões calculou-se a Content Validity Ratio (CVR>0,529). Para investigar o efeito da cartilha educativa no conhecimento dos adolescentes utilizou-se o teste de McNemar (p<0,05). O estudo foi aprovado pelo Comitê de Ética e Pesquisa da Universidade Federal do Piauí. Resultados: a CVR total do roteiro foi de 0,718, representando boa validação de conteúdo do roteiro de questões. Três assertivas foram eliminadas (CVR>0,529). Sobre o conhecimento dos adolescentes, 45,9% melhoraram seu conhecimento, sem diferença significativa (p=0,067). Conclusão: o conhecimento dos adolescentes foi maior em quase metade dos adolescentes no pós-teste, demonstrando que a leitura da cartilha educativa favoreceu o conhecimento sobre a prevenção da Síndrome Metabólica.


Subject(s)
Adolescent , Health Education , Adolescent , Educational Technology , Validation Study , Metabolic Syndrome
7.
HU rev ; 48: 1-7, 2022.
Article in Portuguese | LILACS | ID: biblio-1371596

ABSTRACT

Introdução: A obesidade é uma doença crônica de alta prevalência no Brasil associada a alta morbimortalidade, sendo a cirurgia bariátrica uma proposta válida para seu controle e tratamento. Nota-se que há uma escassez na literatura nacional de informações referentes a dados epidemiológicos, bem como das complicações que envolvem a cirurgia bariátrica. Objetivo: Investigar o perfil epidemiológico de indivíduos adultos submetidos a cirurgia bariátrica realizadas em hospital público de ensino no município de Juiz de Fora - MG. Método: Trata-se de um estudo de natureza analítica, observacional, transversal do tipo inquérito por meio do levantamento de prontuários. Resultados: Dos 466 indivíduos que realizaram a cirurgia bariátrica, a média de idade dos indivíduos foi de 40,2 anos e 85,2% eram do sexo feminino. Cerca de 84% dos pacientes classificaram-se com obesidade grau III. A comorbidade que mais prevaleceu no grupo pesquisado foi a hipertensão arterial (89%), a taxa de mortalidade foi de 1,9% e a frequência de complicações foram mais observadas em pacientes com obesidade grau III (68%). Conclusão: O perfil dos pacientes que buscaram abordagem cirúrgica para obesidade foi predominantemente de mulheres na terceira e quartas décadas de vida, brancas, com obesidade mórbida, tendo como comorbidade mais frequente DM e HAS, sendo que a presença de comorbidades não esteve associada ao aumento no risco de intercorrências do procedimento. A taxa geral de complicações foi baixa e o grau de obesidade esteve diretamente associado à sua ocorrência. A cirurgia bariátrica para tratamento da obesidade mostrou-se segura, com baixa taxa de complicações em um centro especializado, caracterizando, até o momento, a maior casuística nacional.


Introduction: Obesity is a chronic disease of high prevalence in Brazil associated with high morbidity and mortality, and bariatric surgery is a valid proposal for its control and treatment. It is noted that there is a shortage in the national literature of information regarding epidemiological data, as well as complications involving bariatric surgery. Objective: To investigate the epidemiological profile of adult individuals undergoing bariatric surgery performed in a public teaching hospital in the city of Juiz de Fora-MG. Method: This is an analytical, observational, cross-sectional survey-type study through the survey of medical records. Results: Of the 466 individuals who underwent bariatric surgery, the average age of individuals was 40.2 years and 85.2% were female. About 84% of patients classified as having grade III obesity. The most prevalent comorbidity in the researched group was systemic arterial hypertension (89%), the mortality rate was 1.9% and the frequency of complications was more observed in patients with grade III obesity (68%). Conclusion: The profile of patients who sought a surgical approach for obesity was predominantly women in the third and fourth decades of life, white, morbidly obese, with DM and SAH as the most frequent comorbidity, and the presence of comorbidities was not associated with the increase in the risk of complications of the procedure. The overall rate of complications was low and the degree of obesity was directly associated with its occurrence. Bariatric surgery for the treatment of obesity proved to be safe, with a low rate of complications in a specialized center, characterizing, to date, the largest sample in Brazil.


Subject(s)
Bariatric Surgery , Obesity, Morbid , Comorbidity , Prevalence , Metabolic Syndrome , Hospitals, Teaching
8.
Acta Paul. Enferm. (Online) ; 35: eAPE02982, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1364227

ABSTRACT

Resumo Objetivo Avaliar a efetividade de um programa educativo de promoção à saúde na melhora dos domínios da qualidade de vida e no conhecimento da síndrome metabólica. Métodos Ensaio clínico não-randomizado incluindo 61 adultos com síndrome metabólica (49±7,6 anos). Os participantes foram intencionalmente alocados em dois grupos: intervenção (n=31) e controle (n=30). O desfecho primário foi a mudança do conhecimento sobre síndrome metabólica e seus fatores de risco, e o secundário, a melhora da qualidade de vida (SF-36) avaliados em dois momentos, na condição basal e ao final da intervenção (seis meses). Foram utilizados os testes U de Mann Whitney e Wilcoxon, adotando-se nível de significância de 5%. Resultados O programa educativo melhorou o domínio de dor corporal da qualidade de vida no grupo intervenção (p=0,01), embora sem diferença estatística entre os grupos. O conhecimento sobre hipertensão e diabetes (p=0,02), síndrome metabólica (p<0,001) e conhecimento geral (p<0,001) apresentaram aumento significativo no grupo intervenção aos seis meses, o que não ocorreu no grupo controle. Conclusão O programa educativo pode ser uma estratégia efetiva para melhorar a qualidade de vida com destaque para o domínio de dor corporal e aumentar o conhecimento da síndrome metabólica em adultos com a síndrome.


Resumen Objetivo Evaluar la efectividad de un programa educativo de promoción de la salud en la mejora de los dominios de calidad de vida y en los conocimientos del síndrome metabólico. Métodos Ensayo clínico no aleatorizado, que incluyó 61 adultos con síndrome metabólico (49±7,6 años). Los participantes fueron intencionalmente separados en dos grupos: experimental (n=31) y de control (n=30). El criterio principal de valoración fue el cambio de conocimientos sobre síndrome metabólico y sus factores de riesgo, y el secundario, la mejora de la calidad de vida (SF-36), evaluados en dos momentos: en condición basal y al final de la intervención (seis meses). Se utilizaron las pruebas U de Mann-Whitney y de Wilcoxon y se adoptó un nivel de significación de 5 %. Resultados El programa educativo mejoró el dominio de dolor corporal de la calidad de vida en el grupo experimental (p=0,01), aunque no hubo diferencia estadística entre los grupos. Los conocimientos sobre hipertensión y diabetes (p=0,02), síndrome metabólico (p<0,001) y conocimientos generales (p<0,001) presentaron aumento significativo en el grupo experimental a los seis meses, lo que no ocurrió en el grupo de control. Conclusión El programa educativo puede ser una estrategia efectiva para mejorar la calidad de vida, con énfasis en el dominio de dolor corporal, y aumentar los conocimientos sobre el síndrome metabólico en adultos con el síndrome. Registro de Ensaio Clínico Brasileiro (REBEC): RBR-43K52N


Abstract Objective To assess the effectiveness of an educational health promotion program in improving quality of life and knowledge domains of metabolic syndrome. Methods This is a non-randomized clinical trial including 61 adults with metabolic syndrome (49±7.6 years). Participants were intentionally divided into two groups: intervention (n=31) and control (n=30). The primary outcome was the change in knowledge about metabolic syndrome and its risk factors, and the secondary, the improvement in quality of life (SF-36) assessed in two moments, at baseline and at the end of intervention (six months). Mann Whitney and Wilcoxon U tests were used, adopting a significance level of 5%. Results The educational program improved the body ache domain of quality of life in the intervention group (p=0.01), although with no statistical difference between the groups. Knowledge about hypertension and diabetes (p=0.02), metabolic syndrome (p<0.001) and general knowledge (p<0.001) showed a significant increase in the intervention group at six months, which did not occur in the control group. Conclusion The educational program can be an effective strategy to improve quality of life, highlighting the domain of body ache and increasing knowledge of metabolic syndrome in adults with the syndrome.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Quality of Life , Patient Education as Topic/methods , Knowledge , Metabolic Syndrome/prevention & control , Risk Factors
9.
Rev. Méd. Inst. Mex. Seguro Soc ; 59(6): 490-499, 01-dic-2021. tab, grap
Article in Spanish | LILACS | ID: biblio-1355275

ABSTRACT

Introducción: en México existe escasa información respecto al vínculo entre el síndrome metabólico (MetS), el nivel socioeconómico (NSE) y la calidad de vida (CdV) de la población. Objetivo: evaluar la asociación entre sujetos que tienen alto riesgo de desarrollar MetS con NSE y CdV. Métodos: se invitó a participar a pacientes de la UMF-2 del IMSS y del Centro Urbano-SSA Clínica-1. Se recolectaron medidas antropométricas y se aplicaron los cuestionarios AMAI, SF12 y ESF-I para NSE, CdV y MetS, respectivamente. La asociación se determinó calculando rho de Spearman. El riesgo se evaluó mediante regresión logística (razon de momios e intervalo de confianza del 95%). Resultados: la diferencia entre NSE (193  53 frente a 124  50) y CdV (86.3  14.8 frente a 56.0  25.4) fue significativa entre los grupos de bajo y alto riesgo, respectivamente (p < 0.001). Hubo una fuerte correlación negativa entre las puntuaciones de la ESF-I y NSE (rho = -0.623, p < 0.001) así como con la CdV (rho = -0.719, p < 0.001). El riesgo de MetS aumentó al disminuir el NSE (C+: OR = 6.4, IC95%: 3.2 - 13.0; D: OR = 66.1, IC95%: 23.2 - 188.3), mientras que el aumento de la CdV lo atenuó (OR = 0.93, IC95%: 0.91 - 0.94). Interesantemente, la CdV mitigó el efecto del NSE (C+: OR = 4.5, IC95%: 2.1 - 9.6; D: OR = 11.9, IC95%: 3.8 - 37.6). Conclusión: Una menor CdV y NSE aumentan el riesgo de MetS en la región centro de México; sin embargo, el aumento en la CdV podría disminuir el efecto que tiene el NSE en el desarrollo de MetS.


Background: In Mexico there is little information regarding the link between metabolic syndrome (MetS), socioeconomic status (SES) and quality of life (QoL) Objective: To assess the association between subjects who are at high risk of developing MetS with SES and QoL. Methods: Patients attending UMF-2 IMSS or Centro Urbano-SSA Clínica-1 were asked to participate. Anthropometric measures were collected, the AMAI, SF12, and ESF-I questionnaire where apply for SES, QoL, and MetS, respectively. Association were determined by calculating Spearman's rho and the risk (odds ratio and 95% confidence-interval) was assessed using logistic regression. Results: The difference of SES (193  53 vs. 124  50) and QoL (86.3  14.8 vs. 56.025.4) questionnaires were significantly between low-risk and high-risk groups, respectively (p < 0.001). There was a negative correlation between ESF-I and SES (rho = -0.623, p < 0.001) as well as the QoL (rho = -0.719, p < 0.001). MetS risk was augmented by decreasing SES (C+: OR = 6.4, 95%IC: 3.2-13.0; D: OR = 66.1, 95%IC: 23.2-188.3), whereas increasing QoL attenuated it (OR = 0.93, 95%CI: 0.91-0.94). However, QoL mitigated the effect of SES (C+: OR = 4.5, 95%IC: 2.1-9.6; D: OR = 11.9, 95%IC: 3.8-37.6).


Subject(s)
Humans , Male , Female , Quality of Life , Risk Groups , Public Health , Metabolic Syndrome , Association , Logistic Models , Mexico
10.
Arch. latinoam. nutr ; 71(4): 300-309, dic. 2021. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1355226

ABSTRACT

La administración crónica de cafeína evita la alteración de la glucosa postprandial en ratas. El aumento en el consumo de la cafeína alrededor del mundo no es discutible, es así como su investigación se ha vuelto extensa en sus diferentes campos. Objetivo. Analizar los efectos de la administración crónica de cafeína en ratas alimentadas con dieta de cafetería, a través de evaluar índices de consumo, antropométricos y bioquímicos. Materiales y métodos. La dieta de cafetería es un modelo dietético equivalente a las características de la dieta occidental típica que origina síndrome metabólico en humanos. En esta investigación se realizó la administración crónica vía intraperitoneal de cafeína por ocho semanas a ratas adultas macho Wistar alimentadas con dieta de cafetería. Dada la poca evidencia acerca de los efectos biológicos y comportamentales de la administración crónica de dicha sustancia frente a un modelo de dieta de cafetería se evaluaron parámetros de consumo, antropométricos y bioquímicos. Resultados. La dieta de cafetería ocasionó anomalías asociadas al síndrome metabólico; no obstante, la administración de cafeína en las ratas alimentadas con esa dieta resultó ser un factor protector en la glucosa postprandial, más no en la alteración de la tolerancia a la glucosa o perfil lipídico. Conclusiones. La cafeína permitió proteger los niveles de glucosa postprandial al término del experimento y un descenso en el peso corporal y consumo de alimento solo en la primera semana. Sin embargo, no se observaron mejoras significativas en el perfil de lípidos, adiposidad, tolerancia a la glucosa y glucosa plasmática(AU)


Chronic caffeine administration prevents postprandial glucose disturbance in rats. The increase in caffeine consumption is not debatable, this is how his research has become extensive in his different fields. Objective. To analyze the effects of chronic administration of caffeine in rats fed a cafeteria diet, by evaluating consumption, anthropometric and biochemical indices. Previous studies refer to administering caffeine in diets high in carbohydrates and / or in fat that induce obesity or symptoms of metabolic syndrome. Material and methods. The cafeteria diet is a dietary model equivalent to the characteristics of the typical western diet that causes metabolic syndrome in humans. In this research, chronic intraperitoneal administration of caffeine was performed for 8 weeks to adult male Wistar rats fed a cafeteria diet. Given the little evidence about the biological and behavioral effects of the chronic administration of this substance against a cafeteria diet model, consumption, anthropometric and biochemical parameters were evaluated. Results. After eight weeks it was found that the cafeteria diet given to the controls caused abnormalities associated with the metabolic syndrome; regarding the administration of caffeine in the rats fed this diet, the treatment turned out to be a protective factor in postprandial glucose, but not in the alteration of glucose tolerance or lipid profile. Conclusions. Caffeine allowed to protect postprandial glucose levels at the end of the experiment and a decrease in body weight and food consumption only in the first week. However, no significant improvements were seen in lipid profile, adiposity, glucose tolerance, and plasma glucose(AU)


Subject(s)
Animals , Rats , Body Weight , Caffeine/metabolism , Insulin Resistance , Postprandial Period , Reference Parameters , Glucose/analysis , Central Nervous System Stimulants , Adenosine , Rats, Wistar , Metabolic Syndrome , Diabetes Mellitus, Type 2 , Eating , Receptors, Leptin , Obesity
11.
Arch. latinoam. nutr ; 71(4): 261-269, dic. 2021. tab
Article in English | LILACS, LIVECS | ID: biblio-1355151

ABSTRACT

Insulin resistance is a pathological entity that can lead to alterations in lipid metabolism and can increase cardiovascular risk. Objective. The aim of this study was to assess the influence of different sociodemographic variables such as age, sex and social class and healthy habits such as smoking, physical activity and adherence to the Mediterranean diet on the cardiometabolic profile of Spanish workers. Material and methods. A descriptive, cross-sectional study was carried out in 1457 Spanish workers in an attempt to evaluate the effect of healthy habits (physical exercise determined with the IPAQ questionnaire, Mediterranean diet and tobacco consumption) and sociodemographic variables (age, sex and social class) on the values of different insulin resistance scales. Results. The progressive increase in the level of physical activity and high adherence to the Mediterranean diet achieved an improvement in the mean values and in the prevalence of elevated values in all the insulin resistance scales analyzed in this study. Age over 50 years and belonging to the least favored social classes (social classes II-III) were the variables that increased the risk of presenting insulin resistance. Male sex also increased the risk of presenting insulin resistance. Conclusions. The different healthy habits such as vigorous physical exercise and high adherence to the Mediterranean diet improve the values of the different scales that assess insulin resistance(AU)


La resistencia a la insulina es una entidad patológica que puede provocar alteraciones en el metabolismo de los lípidos y puede aumentar el riesgo cardiovascular. Objetivo. En este trabajo se pretende valorar la influencia de diferentes variables sociodemográficas como la edad, el sexo y la clase social y hábitos saludables como el consumo de tabaco, la actividad física y la adherencia a la dieta mediterránea en el perfil cardiometabólico de trabajadores españoles. Material y métodos. Se realizó un estudio descriptivo y transversal en 1457 trabajadores españoles intentando evaluar el efecto de los hábitos saludables (ejercicio físico determinado con el cuestionario IPAQ, dieta mediterránea y consumo de tabaco) y las variables sociodemográficas (edad, sexo y clase social) sobre los valores de diferentes escalas de resistencia a la insulina. Resultados. El aumento progresivo del nivel de actividad física y la alta adherencia a la dieta mediterránea consiguieron una mejoría en los valores medios y en la prevalencia de los valores elevados en todas las escalas de resistencia a la insulina analizadas en este estudio. La edad por encima de los 50 años y la pertenencia a las clases sociales menos favorecidas (clases sociales II-III) fueron las variables que aumentaron el riesgo de presentar resistencia a la insulina. El sexo masculino también incrementó el riesgo de presentar resistencia a la insulina. Conclusiones. Los diferentes hábitos saludables como el ejercicio físico vigoroso y la alta adherencia a la dieta mediterránea mejoran los valores de las diferentes escalas que valoran resistencia a la insulina(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Insulin Resistance , Metabolic Syndrome/complications , Diet, Mediterranean , Lipid Metabolism , Healthy Lifestyle , Cardiometabolic Risk Factors , Social Class , Weights and Measures , Exercise , Nutrition Assessment , Abdominal Circumference , Feeding Behavior
12.
Rev. Ciênc. Méd. Biol. (Impr.) ; 20(3): 441-446, dez 20, 2021. fig, tab
Article in Portuguese | LILACS | ID: biblio-1354290

ABSTRACT

Introdução: a duração do sono tem sido associada à síndrome metabólica e o principal mediador entre tais fatores parece ser a dieta, pois a ingestão de quilocalorias e macronutrientes pode variar conforme as horas dormidas. Objetivo: avaliar se existe associação entre duração do sono e o consumo de energia e de macronutrientes em indivíduos com síndrome metabólica. Metodologia: trata-se de um estudo retrospectivo, transversal, com dados secundários de prontuários de pacientes adultos, atendidos entre os anos de 013-2020. A duração do sono foi categorizada em: curta para ≤6 horas por noite; adequada para 7-8 horas por noite; e longa para ≥9 horas por noite; já os dados dietéticos foram obtidos por meio da aplicação e cálculo de recordatórios alimentares de 24 horas. Após ajustes para idade e sexo, as variáveis foram avaliadas por meio do teste Qui-Quadrado, sendo considerados significativos valores de p< 0,05. Resultados: das 375 pessoas avaliadas, quase metade relatou uma curta duração de sono; entretanto, não foram encontradas associações estatisticamente significativas entre a duração do sono e o consumo calórico (p=0,957), de carboidratos (p=0,975), proteínas (p=0,865) e lipídios (p=0,382). Discussão: a maior prevalência encontrada de curta duração do sono pode estar associada a algumas características sociodemográficas da população estudada, como o sexo feminino, o sedentarismo, o aumento da idade, a baixa renda e a ocupação ativa no mercado de trabalho. Conclusão: indivíduos com síndrome metabólica parecem ter menor tempo de sono, contudo, a associação do sono com o consumo alimentar ainda requer maiores investigações.


Introduction: Sleep duration has been associated with metabolic syndrome and the main mediator between these factors seems to be diet, as the ingestion of kilocalories and macronutrients can vary according to the hours of sleep. Objective: to assess whether there is an association between sleep duration and energy and macronutrient intake in individuals with metabolic syndrome. Methods: this is a retrospective, cross-sectional study, with secondary data from medical records of adult patients, treated between the years 2013- 2020. Sleep duration was categorized into: short for ≤6 hours per night; suitable for 7-8 hours per night; and long for ≥9 hours per night; dietary data were obtained through the application and calculation of 24-hour dietary recalls. After adjustments for age and sex, the variables were evaluated using the Chi-Square test, with values p<0.05 being considered significant. Results: of the 375 people surveyed, nearly half reported a short sleep duration; however, no statistically significant associations were found between sleep duration and caloric intake (p=0.957), carbohydrates (p=0.975), proteins (p=0.865) and lipids (p=0.382). Discussion: the higher prevalence of short sleep duration found may be associated with some sociodemographic characteristics of the studied population, such as female gender, sedentary lifestyle, increasing age, low income and active occupation in the labor market. Conclusion: Individuals with metabolic syndrome seem to have less sleep time; however, the association of sleep with food consumption still requires further investigation.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Sleep , Energy Intake , Nutrients , Metabolic Syndrome , Cross-Sectional Studies , Retrospective Studies
13.
Arch. endocrinol. metab. (Online) ; 65(6): 704-712, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1349990

ABSTRACT

ABSTRACT Objective: Thus, the aim of this study was to identify the cutoff point of the TyG index for the diagnosis of insulin resistance (IR), according to two different diagnostic criteria of metabolic syndrome in a rural Brazilian population. Materials and methods: The study population consisted of 790 family farmers from 18 to 59 years old. The triglyceride-glucose index (TyG index) was calculated, and the Metabolic Syndrome was defined using the NCEP-ATPIII and IDF criteria. Mann-Whitney U test was used to analyze the association of quantitative and qualitative variables. When the qualitative variable had three or more categories, the comparison between the means was performed by the Kruskal-Wallis test (using the Mann-Whitney U Test two by two to identify the differences). For correlations, Spearman's correlation test was used. The cutoff values of TyG index for MetS were obtained using the Receiver Operating Characteristic (ROC) curve analysis with the area under the curve (AUC) and the Youden Index. Results: The median TyG values increased according to the aggregation of the components of MetS. The AUCs and Youden's cutoff point for TyG index according to the NCEP and IDF diagnostic criteria were 0.873, Ln 4.52 (sensitivity: 84.30%; specificity: 75.75%), and 0.867, Ln 4.55 (sensitivity: 80.0%; specificity: 79.82%), respectively. Conclusion: A cutoff point of Ln 4.52 was defined, and it can be used both in clinical practice and epidemiological studies. It represents an important tool for promotion, protection and recovery health of rural populations.


Subject(s)
Humans , Adolescent , Adult , Young Adult , Insulin Resistance , Metabolic Syndrome/diagnosis , Triglycerides , Blood Glucose , Cross-Sectional Studies , Glucose , Middle Aged
15.
Arq. bras. cardiol ; 117(4): 737-747, Oct. 2021. tab, graf
Article in Portuguese | LILACS | ID: biblio-1345234

ABSTRACT

Resumo Fundamento A síndrome metabólica é caracterizada por um conjunto de comorbidades. Durante a síndrome, observam-se alterações estruturais no sistema cardiovascular, especialmente o remodelamento vascular. Uma das causas predisponentes para essas alterações é a inflamação crônica oriunda de mudanças na estrutura e composição do tecido adiposo perivascular. Atorvastatina é eficaz no tratamento das dislipidemias. No entanto, seus efeitos pleiotrópicos não são totalmente compreendidos. Supõe-se que, durante a síndrome metabólica, ocorre remodelamento vascular e que o tratamento com atorvastatina pode ser capaz de atenuar tal condição. Objetivos Avaliar os efeitos do tratamento com atorvastatina sobre o remodelamento vascular em modelo experimental de síndrome metabólica. Métodos Camundongos Swiss receberam dieta controle ou dieta hiperglicídica por 18 semanas. Após 14 semanas de dieta, os camundongos foram tratados com veículo ou atorvastatina (20mg/kg) durante 4 semanas. Foram avaliados o perfil nutricional e metabólico por testes bioquímicos; análise estrutural da artéria aorta por histologia e dosagem de citocinas por ensaio imunoenzimático. O nível de significância aceitável para os resultados foi p <0,05. Resultados A dieta hiperglicídica promoveu o desenvolvimento de síndrome metabólica. Tal fato culminou no remodelamento hipertrófico do músculo liso vascular e tecido adiposo perivascular. Além disso, houve aumentos das citocinas TNF-α e IL-6 circulantes e no tecido adiposo perivascular. O tratamento com atorvastatina reduziu significativamente os danos metabólicos, o remodelamento vascular e os níveis de citocinas. Conclusão Atorvastatina ameniza danos metabólicos associados à síndrome metabólica induzida por dieta hiperglicídica, além de atenuar o remodelamento vascular, sendo esses efeitos associados à redução de citocinas pró-inflamatórias.


Abstract Background Metabolic syndrome is characterized by an array of comorbidities. During this syndrome, structural changes are observed in the cardiovascular system, especially vascular remodeling. One of the predisposing causes for these changes is chronic inflammation resulting from changes in the structure and composition of perivascular adipose tissue. Atorvastatin is effective in the treatment of dyslipidemias. However, its pleiotropic effects have not been completely understood. We hypothesize that metabolic syndrome may lead to vascular remodeling and that atorvastatin therapy may be able to attenuate this condition. Objectives To assess the effects of atorvastatin therapy on vascular remodeling in an experimental model of metabolic syndrome. Methods Swiss mice received a control diet or a hyperglicemic diet for 18 weeks. After 14 weeks of diet, mice were treated with vehicle or atorvastatin (20mg/kg) during for 4 weeks. Nutritional and metabolic profiles were assessed by biochemical tests; moreover, a histological assessment of aorta structure was conducted, and cytokine levels were determined by the immunoenzyme assay. The acceptable level of significance for the results was set at p<0.05. Results Hyperglicemic diet promoted the development of metabolic syndrome. It indeed culminated in hypertrophic remodeling of vascular smooth muscle and perivascular adipose tissue. Furthermore, there were increases in the levels of circulating TNF-α and IL-6 and in the perivascular adipose tissue. Atorvastatin therapy significantly reduced metabolic damages, vascular remodeling, and cytokine levels. Conclusion Atorvastatin attenuate metabolic damages associated with metabolic syndrome induced by hyperglycemic diet, in addition to attenuating vascular remodeling; both effects are associated with reduced levels of pro-inflammatory cytokines.


Subject(s)
Animals , Mice , Metabolic Syndrome/drug therapy , Adipose Tissue , Cytokines , Vascular Remodeling , Atorvastatin/pharmacology
16.
Revista brasileira de ciência e movimento ; 29(1): [1-31], nov. 2021. tab, ilus
Article in Portuguese | LILACS | ID: biblio-1348165

ABSTRACT

Este estudo tem como objetivo comparar e discutir, a partir de estudos científicos publicados, o efeito crônico do treinamento resistido sobre a pressão arterial. Foi realizada uma revisão sistemática de ensaios clínicos controlados randomizados. A busca dos artigos foi realizada nas bases de dados SciELO, PubMed e Biblioteca Virtual da Saúde. Foram selecionados artigos publicados a partir de 2015, com avaliação da pressão arterial antes e após um período de treinamento resistido e com um grupo controle. Nos 18 estudos selecionados, 551 participantes foram identificados, incluindo idosos, obesos, hipertensos, diabéticos, indivíduos com síndrome metabólica e indivíduos saudáveis, com idade média variando entre 15,4 e 87,7 anos. A maioria dos estudos selecionados realizou uma intervenção de treinamento resistido com exercícios dinâmicos tradicionais para membros inferiores e superiores, com duração de 12 semanas e frequência de 3 vezes por semana. O volume de treinamento apresentado nos estudos variou entre 1 e 5 séries de 3 a 20 repetições por exercício. A intensidade foi apresentada em percentual de uma repetição máxima, percentual de 10 repetições máximas, repetições máximas e percepção subjetiva de esforço. O intervalo de descanso entre os exercícios variou entre 30 e 180 segundos. A metanálise indicou que o treinamento resistido reduziu significativamente a pressão arterial sistólica em -3,38 mmHg ([IC 95% = -5,82; -0,95] p < 0,01; I² = 76%) e a pressão arterial diastólica em -1,95 mmHg ([IC 95% = -3,12; -0,78] p < 0,01; I² = 58%). De acordo com os resultados desta revisão, o treinamento resistido sozinho é mais efetivo em reduzir a pressão arterial de repouso do que o não treinamento, principalmente pressão arterial sistólica; com maior redução em idosos, pré-hipertensos e hipertensos. Sendo assim, o treinamento resistido pode ser um método a ser indicado na prevenção e tratamento da hipertensão arterial sistêmica.(AU)


This study aims to compare and discuss, based on published scientific studies, the chronic effect of resistance training on blood pressure. A systematic review of randomized controlled clinical trials was performed. The search for articles was carried out in the SciELO, PubMed and Biblioteca Virtual da Saúde databases. Articles published from 2015 onwards, with blood pressure assessment before and after a period of resistance training and with a control group, were selected. In the 18 selected studies, 551 participants were identified, including the elderly, obese, hypertensive, diabetics, subjects with metabolic syndrome and healthy subjects, with a mean age ranging between 15,4 and 87,7 years. Most of the selected studies carried out a resistance training intervention with traditional dynamic exercises for lower and upper limbs, lasting 12 weeks and frequency of 3 times a week. The volume of training presented in the studies varied between 1 and 5 sets of 3 to 20 repetitions per exercise. The intensity was presented as a percentage of a maximum repetition, a percentage of 10 maximum repetitions, maximum repetitions and perceived exertion. The rest interval between exercises varied between 30 and 180 seconds. The metaanalysis indicated that resistance training significantly reduced systolic blood pressure by -3,38 mmHg ([95% CI = -5,82; -0,95] p <0,01; I² = 76%) and blood pressure diastolic at -1,95 mmHg ([95% CI = -3,12; -0,78] p <0,01; I² = 58%). According to the results of this review, resistance training alone is more effective in reducing resting blood pressure than non-training, especially systolic blood pressure; with greater reduction in elderly, pre-hypertensive and hypertensive subjects. Therefore, resistance training can be a method to be indicated in the prevention and treatment of systemic arterial hypertension.(AU)


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Physical Endurance , Exercise , Metabolic Syndrome , Resistance Training , Arterial Pressure , Systematic Review , Aged , Meta-Analysis , Libraries, Digital , Diabetes Mellitus , Healthy Volunteers , Endurance Training , Hypertension , Obesity
17.
Revista brasileira de ciência e movimento ; 29(1): [1-28], nov. 2021. tab, ilus
Article in Portuguese | LILACS | ID: biblio-1348230

ABSTRACT

: O exercício físico, em especial a corrida de rua tem sido recomendada para prevenção e tratamento de doenças crônicas não transmissíveis. O objetivo desta revisão sistemática foi verificar os efeitos de diferentes métodos de treinamento sobre os indicadores cardiometabólicos de corredores recreacionais. As bases de dados eletrônicas utilizadas na presente pesquisa foram: PUBMED, SCIENCE DIRECT, LILACS e COCHRANE LIBRARY, usando os descritores agrupados segundo o método PICO; População ("adults" OR "young adult" OR "middle aged") AND Intervenção ("endurance training" OR "aerobic training" OR "running") OR Comparação ("recreational runners" OR "jogging") AND Outcome/Desfecho ("cardiovascular risk factors" OR "cardiometabolic risk factors" OR "metabolic syndrome"). Na seleção os artigos foram excluídos por título, resumo e texto. Obteve-se um total de 813 artigos encontrados, no qual nove (9) preencheram os critérios de inclusão e baixo risco de viés de acordo com a Escala Testex. Foram encontrados três métodos de treinamento: Combinado (Contínuo +Intervalado); Contínuo e Intervalado. Considerando a somatória das amostras dos nove estudos, um total de 604 indivíduos (466 homens e 138 mulheres) participaram dos ensaios. Os diferentes métodos de treinamentos resultaram na redução dos níveis de triglicerídeos, insulina e glicose e na redução do colesterol total e LDL, e consequentemente o aumento do HDL. Na composição corporal houve diminuição significativa do peso e da gordura corporal, do IMC, na medida da circunferência da cintura, e no aumento da capacidade aeróbia (VO2). Concluiu-se que os treinamentos combinado, contínuo e intervalado podem ser aplicados para melhora dos indicadores cardiometabólicos, cada um dentro da sua especificidade de frequência, volume e intensidade.(AU)


Physical exercise, especially running, has been recommended for the prevention and treatment of chronic non-communicable diseases. The objective of this systematic review was to verify the effects of different training methods on the cardiometabolic indicators of recreational runners. The electronic databases used in the present research were: PUBMED, SCIENCE DIRECT, LILACS and COCHRANE LIBRARY, using the descriptors grouped according to the PICO method; Population ("adults" OR "young adult" OR "middle aged") AND Intervention ("endurance training" OR "aerobic training" OR "running") OR Comparison ("recreational runners" OR "jogging") AND Outcome / Outcome ("Cardiovascular risk factors" OR "cardiometabolic risk factors" OR "metabolic syndrome"). In the selection, articles were excluded by title, abstract and text. A total of 813 articles were obtained, in which nine (9) met the inclusion criteria and low risk of bias according to the Testex Scale. Three training methods were found: Combined (Continuous + Interval); Continuous and Interval. Considering the sum of the samples from the nine studies, a total of 604 individuals (466 men and 138 women) participated in the trials. The different training methods resulted in a reduction in the levels of triglycerides, insulin and glucose and in the reduction of total cholesterol and LDL, and consequently an increase in HDL. In body composition, there was a significant decrease in weight and body fat, in BMI, as measured by waist circumference, and in increased aerobic capacity (VO2). It is concluded that combined, continuous and interval training can be applied to improve cardiometabolic indicators, each within its specific frequency, volume and intensity.(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Running , Physical Fitness , Endurance Training , Triglycerides , Body Composition , Exercise , Cholesterol , Metabolic Syndrome , Diabetes Mellitus , Fats , Arterial Pressure , High-Intensity Interval Training , Noncommunicable Diseases , Heart Disease Risk Factors , Cardiometabolic Risk Factors , Glucose , Insulin , Jogging
18.
Rev. medica electron ; 43(5): 1395-1408, 2021. graf
Article in Spanish | LILACS | ID: biblio-1352119

ABSTRACT

RESUMEN El síndrome metabólico comprende un conjunto de factores de riesgo cardiovascular asociado a resistencia a la insulina, que propicia la aparición de enfermedad cardiovascular y de diabetes mellitus tipo 2. Su etiología se atribuye a la combinación de factores genéticos y ambientales, asociados al estilo de vida, que favorecen un estado proinflamatorio y protrombótico que empeora el cuadro clínico de los pacientes con covid-19. El objetivo de la revisión consistió en analizar el estado actual del conocimiento científico en las investigaciones sobre la interrelación entre los desórdenes del metabolismo glucídico y el síndrome metabólico, asociados a la condición proinflamatoria exacerbada en pacientes de covid-19. Se hicieron búsquedas en las bases de datos PubMed, SciELO, ClinicalKey y LILACS. Al proceso proinflamatorio generado por malos hábitos alimentarios, la sobrealimentación calórica de alto índice glicémico, y estilos de vida sedentarios, se atribuye un papel relevante en la patogénesis del síndrome metabólico, así como en sus posibles complicaciones en pacientes de covid-19 con comorbilidades asociadas. Es posible reducir la condición inflamatoria del síndrome metabólico mediante modificaciones en el estilo de vida y hábitos alimentarios, que prevengan la obesidad y sus efectos en la resistencia a la insulina, lo cual propicia reducir la gravedad asociada a los procesos inflamatorios inherentes (AU).


ABSTRACT Metabolic syndrome includes a set of cardiovascular risk factors associated with resistance to insulin, favoring the appearance of cardiovascular disease and diabetes mellitus type 2. Its etiology is attributed to the combination of genetic and environmental factors, associated to lifestyle, and favoring a proinflammatory and prothrombotic status that worsens the clinical characteristics of the patients with COVID-19. The objective of the review was to analyze the current state of the scientific knowledge in research on the interrelationship between glucide metabolism disorders and metabolic syndrome, associated with the exacerbated proinflammatory condition in COVID-19 patients. Searches were conducted in PubMed, SciELO, CinicalKey, and LILACS databases. A relevant role in the metabolic syndrome pathogenesis is attributed to the inflammatory process generated by poor eating habits, high caloric overfeeding, and to sedentary lifestyle, and also to possible complications with associated comorbidities in COVID-19 patients. It is possible to reduce the metabolic syndrome inflammatory condition through life style and alimentary habits changes that prevent obesity and its effects on insulin resistance and propitiate the reduction of the disease severity associated with the inherent inflammatory processes (AU).


Subject(s)
Humans , Male , Female , Coronavirus Infections/complications , Metabolic Syndrome/diagnosis , Patients , Insulin Resistance , Metabolic Syndrome/therapy , Inflammation/complications , Obesity
19.
Medicina (B.Aires) ; 81(5): 843-845, oct. 2021. graf
Article in English | LILACS | ID: biblio-1351058

ABSTRACT

Abstract We present a case of subcutaneous insulin resistance syndrome, a rare entity, consisting of subcutaneous and intramuscular insulin resistance, with normal or almost normal sensitivity to insulin when administered intravenously. Its cause is unknown and its treatment is challenging. Our patient required a pancreas transplant.


Resumen Presentamos un caso de síndrome de resistencia subcutánea a la insulina, entidad in frecuente, que consiste en resistencia a la insulina por vía subcutánea e intramuscular, con sensibilidad normal o casi normal a la insulina cuando se aplica por vía intravenosa. Se desconoce su causa y su tratamiento es un desafío. Nuestra paciente requirió trasplante de páncreas.


Subject(s)
Humans , Insulin Resistance , Pancreas Transplantation , Metabolic Syndrome , Diabetes Mellitus, Type 1 , Insulin
20.
Femina ; 49(9): 520-524, 20211030.
Article in Portuguese | LILACS | ID: biblio-1342318

ABSTRACT

A síndrome dos ovários policísticos (SOP) é frequentemente acompanhada de distúrbio metabólico, principalmente dos carboidratos e dos lipídeos, aumentando o risco de síndrome metabólica. Por essa razão, alguns investigadores ainda denominam a SOP de síndrome metabólica-reprodutiva. O objetivo deste capítulo é descrever as principais repercussões metabólicas, bem como como investigá-las e saber como suas consequências podem ser deletérias para a saúde da mulher. Esta é uma revisão narrativa mostrando a implicação do metabolismo dos carboidratos e dos lipídeos nas dislipidemias, bem como da síndrome metabólica sobre o sistema reprodutor, e o risco cardiovascular da mulher com SOP. Conclui-se que o manejo adequado dos distúrbios metabólicos na SOP é benéfico a curto e a longo prazo tanto para o sistema reprodutor quanto para o cardiovascular.(AU)


Subject(s)
Humans , Female , Polycystic Ovary Syndrome/metabolism , Metabolic Syndrome/diagnosis , Metabolic Syndrome/physiopathology , Insulin Resistance , Risk Factors , Glucose Intolerance/diagnosis , Glucose Metabolism Disorders/physiopathology , Diabetes Mellitus, Type 2/diagnosis , Dyslipidemias/physiopathology , Lipid Metabolism Disorders/physiopathology
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