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Article in Chinese | WPRIM | ID: wpr-969907


To explore the relationship between the early or delayed age at natural menopause and metabolic syndrome (MS) in women. A total of 4 734 natural menopausal women who completed the baseline survey from November 2017 to January 2020 in the Guangzhou Middle-aged and Elderly Chronic Disease Prospective Cohort Study were selected in this cross-sectional study. Data on general demographic characteristics, disease history and female physiological health indicators were collected. Logistic regression model and restricted cubic spline curve were used to analyze the relationship between the age at natural menopause and MS. The results showed that the mean age of the subjects was (60±6) years old. The median (Q1,Q3) age at natural menopause was 50 (49, 52) years old, and the prevalence of MS was 14.8%(699/4 734). After adjusting for confounders, the age at natural menopause was closely related to MS in an approximate"U"shape. Compared with the group of normal age at natural menopause, the early age at menopause (OR=1.52, 95%CI: 1.12-2.06) and delayed age at menopause (OR=1.77, 95%CI: 1.36-2.30) had a higher risk of MS. In the group with time since menopause ≤6 years and 7-9 years, the risk of MS in the group with delayed age at menopause was 2.40 times (95%CI: 1.54-3.75) and 2.19 times (95%CI: 1.11-4.31) higher than that in the group with normal menopausal age, respectively. In conclusion, the early and delayed age at natural menopause increased the risk of MS. The increased risk of MS in delayed age at natural menopause mainly occurred within 10 years since menopause.

Middle Aged , Aged , Female , Humans , Child , Postmenopause , Metabolic Syndrome/epidemiology , Prospective Studies , Cross-Sectional Studies , Menopause/physiology , Risk Factors
Chinese Journal of Epidemiology ; (12): 568-574, 2023.
Article in Chinese | WPRIM | ID: wpr-985528


Objective: To understand the depression status and its influencing factors in elderly patients with MS in China and to explore the correlation between various components of elderly MS and depression. Methods: This study is based on the "Prevention and Intervention of Key Diseases in Elderly" project. We used a multi-stage stratified cluster random sampling method to complete 16 199 elderly aged 60 years and above in 16 counties (districts) in Liaoning, Henan, and Guangdong Provinces in 2019, excluding 1 001 missing variables. Finally, 15 198 valid samples were included for analysis. The respondents' MS disease was obtained through questionnaires and physical examinations, and the respondents' depression status within the past half month was assessed using the PHQ-9 Depression Screening Scale. The correlation between elderly MS and its components and depression and its influencing factors were analyzed by logistic regression. Results: A total of 15 198 elderly aged 60 years and above were included in this study, with the prevalence of MS at 10.84% and the detection rate of depressive symptoms in MS patients at 25.49%. The detection rates of depressive symptoms in patients with 0, 1, 2, 3, and 4 MS abnormal group scores were 14.56%, 15.17%, 18.01%, 25.21%, and 26.65%, respectively. The number of abnormal components of MS was positively correlated with the detection rate of depressive symptoms, and the difference between groups was statistically significant (P<0.05). The risk of depression symptoms in patients with MS, overweight/obesity, hypertension, diabetes, and dyslipidemia was 1.73 times (OR=1.73, 95%CI:1.51-1.97), 1.13 times (OR=1.13, 95%CI:1.03-1.24), 1.25 times (OR=1.25, 95%CI:1.14-1.38), 1.41 times (OR=1.41, 95%CI:1.24-1.60), 1.81 times (OR=1.81,95%CI:1.61-2.04), respectively, more than those without the disease. Multivariate logistic regression analysis showed that the detection rate of depressive symptoms in patients with sleep disorders was higher than that with normal sleep (OR=4.89, 95%CI: 3.79-6.32). The detection rate of depressive symptoms in patients with cognitive dysfunction was 2.12 times higher than that in the average population (OR=2.12, 95%CI: 1.56-2.89). The detection rate of depressive symptoms in patients with impaired instrumental activities of daily living (IADL) was 2.31 times (OR=2.31, 95%CI: 1.64-3.26) higher than that in the average population. Tea drinking (OR=0.73, 95%CI: 0.54-0.98) and physical exercise (OR=0.67, 95%CI: 0.49-0.90) seemed to be protective factors for depression in elderly MS patients (P<0.05). Conclusions: Older patients with MS and its component abnormalities have a higher risk of depression than the average population. Sleep disorders, cognitive impairment, and IADL impairment are important influencing factors for depression in elderly MS patients, while tea drinking and physical exercise may help to reduce the risk of the disease.

Aged , Humans , Metabolic Syndrome/epidemiology , Activities of Daily Living/psychology , Depression/epidemiology , China/epidemiology , Tea , Risk Factors
Article in Portuguese | LILACS, CONASS, ColecionaSUS, SES-GO | ID: biblio-1511499


O desenvolvimento da síndrome metabólica após o transplante renal (TxR) é evidenciado na literatura e se caracteriza por alterações que conferem a redução da função do enxerto. Objetivo: O objetivo deste trabalho é descrever a prevalência da síndrome metabólica e identificar variáveis que se associam à síndrome metabólica em receptores de TxR tardio. Metodologia: Trata-se de um estudo transversal analítico realizado com pacientes receptores de TxR. Foram incluídos participantes com idade superior ou igual a 18 anos, receptores de TxR tardio em acompanhamento superior a 6 meses. A análise descritiva dos dados foi expressa por médias, desvio padrão, medianas e percentuais. A normalidade dos dados foi verificada pelo teste de Shapiro-Wilk ao nível de 5% de significância. Aplicou-se o teste de comparação de médias para duas amostras independentes, teste t de Student. Foi utilizado o teste de correlação de Pearson para avaliar as possíveis relações existentes entre a variável tempo pós TxR com as outras variáveis de interesse. Resultados: Ao avaliar 43 pacientes com idade média de 50,9 ± 9,8 anos, notou-se que a síndrome metabólica esteve presente em 53,85% dos voluntários e que se associou ao peso prévio (p= 0,018), concentrações séricas de triglicerídeos (p= 0,001), menores médias de HDL (p= 0,053) e, também, foi verificada uma associação marginal com a circunferência da cintura (p= 0,051). A SM foi prevalente no período pós TxR. Ainda, as maiores médias de peso prévio ao TxR, de circunferência da cintura, de triglicerídeos e as menores médias de HDL se associaram à SM

The onset of metabolic syndrome (MS) after kidney transplantation (KTx) is evidenced in the literature and this is characterized by alterations that confer a reduction in the function of the transplantation. Objective: The aim of this research is to describe the prevalence of the metabolic syndrome and to identify the variables that are associated with the metabolic syndrome in recipients of belated KTx. Methods: This is an analytical cross-sectional study carried out with patients receiving KTx. Participants aged 18 years or older, recipients of late KTx with follow-up longer than 6 months, were included. The descriptive analysis of the data was expressed as means, standard deviation, medians and percentages. Data normality was verified using the Shapiro-Wilk test at a 5% significance level. The mean comparison test was applied for two independent samples, Student's t test. Pearson's correlation test was used to assess possible association between the variable time after KTx and the other variables of interest. Results: Forty-three patients with a mean age of 50.9 ± 9.8 years were evaluated and metabolic syndrome was present in 53.85% of the volunteers. There was an association with previous weight (p= 0.018), serum triglyceride concentrations (p= 0.001) and lower HDL means (p= 0.053) and and a marginal association with waist circumference (p=0,0051). MS was prevalent in the post-KTx period. Furthermore, the highest means of weight prior to KTx, waist circumference, TG and the lowest means of HDL were associated with MS

Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Kidney Transplantation/adverse effects , Metabolic Syndrome/epidemiology , Diabetes Mellitus , Transplant Recipients , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use
Article in Chinese | WPRIM | ID: wpr-986870


OBJECTIVE@#To analyze the association between different growth patterns and metabolic syndrome in children and adolescents aged 7 to 17 years, and to provide suggestions for the prevention and control of metabolic syndrome in Chinese children and adolescents.@*METHODS@#Data were collected from the research project "Development and Application of Technology and Related Standards for Prevention and Control of Major Diseases among Students" of public health industry in 2012. This project is a cross-sectional study design. A total of 65 347 students from 93 primary and secondary schools in 7 provinces including Guangdong were selected by stratified cluster random sampling method. Given the budget, 25% of the students were randomly selected to collect blood samples. In this study, 10 176 primary and middle school students aged 7 to 17 years with complete physical measurements and blood biochemical indicators were selected as research objects. Chi-square test was used to compare the distribution differences of growth patterns under different demographic characteristics. Birth weight, waist circumference and blood biochemical indexes were expressed in the form of mean ± standard deviation, and the differences among different groups were compared by variance analysis. Binary Logistic regression model was used to analyze the relationship between different growth patterns and metabolic syndrome in children and adolescents aged 7 to 17 years.@*RESULTS@#The prevalence of metabolic syndrome in children and adolescents was 6.56%, 7.18% in boys and 5.97% in girls. The risk of metabolic syndrome was higher in the catch-down growth group than in the normal growth group (OR=1.417, 95%CI: 1.19-1.69), and lower in the catch-up growth group(OR=0.66, 95%CI: 0.53-0.82). After adjusting for gender, age and so on, the risk of developing metabolic syndrome in the catch-down growth group was higher than that in the normal growth group (OR=1.25, 95%CI: 1.02-1.52), but there was no significant difference between the catch-up growth group and the normal growth group (OR=0.79, 95%CI: 0.62-1.01). Stratified analysis showed that the association between different growth patterns and metabolic syndrome was statistically significant in the 7-12 years group, urban population, and Han Chinese student population.@*CONCLUSION@#There is a correlation between different growth patterns and metabolic syndrome in children and adolescents. The risk of developing metabolic syndrome in children and adolescents with catch-down growth is higher than that in the normal growth group, which suggests that attention should be paid to the growth and development of children and adolescents, timely correction of delayed growth and prevention of adverse health outcomes.

Male , Female , Humans , Child , Adolescent , Metabolic Syndrome/epidemiology , Cross-Sectional Studies , Students , Urban Population , Asian People , China/epidemiology , Prevalence
Rev. cuba. med ; 61(2): e2483, abr.-jun. 2022. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1408988


Introducción: El estrés académico resulta de la confrontación de un individuo con las demandas del medio universitario, lo cual puede producir cambios a nivel neuro-endocrino-inmunológico y generar un estado de inflamación crónica en donde los niveles de proteína C-reactiva aumentan. Objetivo: Determinar los niveles de estrés académico y proteína C-reactiva en estudiantes de medicina y su posible asociación con síndrome metabólico. Métodos: Se realizó un estudio observacional descriptivo de corte longitudinal que determinó el estrés académico en 68 estudiantes de medicina (41 mujeres y 27 hombres). Se obtuvo información sociodemográfica y clínica de cada estudiante. Se aplicó un cuestionario para la evaluación del estrés académico y se obtuvieron dos muestras de sangre para realizar dos pruebas de proteína C-reactiva de alta sensibilidad en dos tiempos diferentes. Resultados: Pese a que se observaron niveles altos de estrés académico y proteína C-reactiva, no hubo una asociación directa; sin embargo, se encontraron relaciones significativas entre proteína C-reactiva y las variables clínicas, además de un riesgo alto de desarrollar síndrome metabólico. Conclusiones: Se observaron altos niveles de estrés académico asociado a las demandas y exigencias de un programa de medicina con acreditación de alta calidad. Los altos niveles de proteína C-reactiva fueron asociados a los altos niveles de obesidad abdominal, lo que hace que un número significativo de estudiantes se encuentre en riesgo de desarrollar enfermedades cardiovasculares y diabetes mellitus tipo 2, sobre todo aquellos en los que se detectó prehipertensión. No se encontró una relación significativa entre el estrés académico y los niveles de proteína C-reactiva(AU)

Introduction: Academic stress results from the confrontation of an individual with the demands of the university environment, which can produce changes at the neuro-endocrine-immunological level and generate a state of chronic inflammation where the levels of C-reactive protein increase. Objective: To determine the levels of academic stress and C-reactive protein in medical students and their possible association with metabolic syndrome. Methods: A longitudinal descriptive observational study was conducted to determine academic stress in 68 medical students (41 women and 27 men). Sociodemographic and clinical information was obtained from each student. A questionnaire was applied to assess academic stress and two blood samples were obtained to perform two high-sensitivity C-reactive protein tests at two different times. Results: Although high levels of academic stress and C-reactive protein were observed, there was no direct association; however, significant relationships were found between C-reactive protein and clinical variables, in addition to a high risk of developing metabolic syndrome. Conclusions: High levels of academic stress associated with the demands and requirements of a medicine program with high quality accreditation were observed. High levels of C-reactive protein were associated with high levels of abdominal obesity, which means that a significant number of students are at risk of developing cardiovascular diseases and type 2 diabetes mellitus, especially those in whom prehypertension was detected. No significant relationship was found between academic stress and C-reactive protein levels(AU)

Humans , Male , Female , Young Adult , Stress, Psychological/psychology , C-Reactive Protein/drug effects , Metabolic Syndrome/epidemiology , Education, Medical , Epidemiology, Descriptive , Longitudinal Studies , Colombia , Observational Study
Rev. cuba. med ; 61(1)mar. 2022.
Article in Spanish | LILACS, CUMED | ID: biblio-1408969


Estimado director: Hemos leído con interés el artículo Prevalencia del síndrome metabólico en la población dos consultorios del Policlínico Primero de Enero, de los autores Rivero Sabournin y otros.1 Dicho trabajo demuestra el potencial investigativo en la Atención Primaria de Salud, así como la pertinencia de este escenario en los estudios epidemiológicos. Para el desarrollo de la investigación sus autores se basan en los criterios de síndrome metabólico (SM) del National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III),1 aunque resulta imprescindible evaluar los criterios de la Clasificación Consensuada o Armonizada de Alberti y otros del año 2009,2 los cuales constituyen la guía más importante para la evaluación por parte del médico de cabecera de los pacientes que pudieran padecer de SM. Otro elemento importante en esta investigación es que se resalta la relación SM y envejecimiento, aunque no se argumenta cuáles pudieran ser los nexos entre ellos. Actualmente se considera que sea el endotelio (END) y la disfunción endotelial (DISF) la vía común de cada una de estas alteraciones como lo han propuesto varios autores: niveles elevados de ácidos grasos,3 envejecimiento,4 oxidación de LDL,5 hiperglucemia,6 niveles séricos de adipoquinas7,8 y las especies reactivas del oxígeno.9 Para un abordaje de esta relación SM-E-END sería necesario analizar que la base fisiopatológica del SM es la insulinorresistencia (IR) y que, precisamente, el endotelio tiene una función importante, donde la insulina (INS) logra desempeñar su función.8 En el endotelio se produce el factor de crecimiento similar a la INS (IGF, según sus siglas en inglés)9 y es donde se encuentran proteínas de membrana que sirven de transportadores a la INS. Una vez que se instaura el daño endotelial o la disfunción endotelial (DE), la pérdida...(AU)

Humans , Male , Female , Aged , Aged, 80 and over , Primary Health Care , Aging/physiology , Metabolic Syndrome/epidemiology
Rev. cuba. med ; 61(1)mar. 2022.
Article in Spanish | LILACS, CUMED | ID: biblio-1408981


Introducción: La disbiosis conocida como la alteración de la relación simbiótica entre la microbiota intestinal y el huésped están implicados en la patogenia de la enfermedad cardiovascular aterosclerótica. Objetivo: Realizar una revisión documental sobre los mecanismos fisiopatológicos que relacionan los metabolitos bioactivos generados por la disbiosis intestinal con el desarrollo y progresión de la enfermedad cardiovascular aterosclerótica. Métodos: Se utilizó el motor de búsqueda Google Académico y se consultaron artículos de libre acceso en las bases de datos Pubmed, SciELO, Lilacs, Cumed y Hinari desde septiembre 2020 hasta el mes de marzo 2021. Las palabras clave utilizadas para esta revisión fueron:microbioma, microbiota intestinal, disbiosis, aterosclerosis, enfermedad cardiovascular y sus equivalentes en inglés, según el descriptor de Ciencias de la Salud (DeCS). Se consideraron artículos originales, de revisión, revisiones sistemáticas y metaanálisis posteriores al año 2015. Se revisaron un total de 73 artículos. Desarrollo: Las relaciones fisiopatológicas entre la disbiosis intestinal y las enfermedades cardiovasculares son complejas, ya que se influyen mutuamente a través de los sus toxinas endógenas (metabolitos bioactivos), el sistema circulatorio, las respuestas inmunitarias y los cambios metabólicos. Las investigaciones futuras deberían centrarse en dilucidar los actores moleculares subyacentes e identificar si las vías que interconectan la disbiosis intestinal con la ECA son causales, correlacionales o consecuentes. Conclusiones: La evidencia acumulada sostiene que la disbiosis de la microbiota intestinal está involucrada en la síntesis de metabolitos proaterogénicos los cuales modulan los mecanismos implicados en la fisiopatología de la ECA(AU)

Introduction: Dysbiosis is known as the alteration of the symbiotic relationship between the intestinal microbiota and the host is involved in the pathogenesis of atherosclerotic cardiovascular disease. Objective: To carry out a documentary review on the pathophysiological mechanisms that relate the bioactive metabolites generated by intestinal dysbiosis with the development and progression of atherosclerotic cardiovascular disease. Methods: The Google Scholar search engine was used and free access articles were consulted in Pubmed, SciELO, Lilacs, Cumed and Hinari databases from September 2020 to March 2021. The keywords used for this review were microbiome, gut microbiota, dysbiosis, atherosclerosis, cardiovascular disease and their English equivalents, according to the Health Sciences (DeCS) descriptor. Original articles, review articles, systematic reviews and meta-analyses after 2015 were considered. A total of 73 articles were reviewed. Findings: The pathophysiological relationships between intestinal dysbiosis and cardiovascular diseases are complex, since they influence each other through their endogenous toxins (bioactive metabolites), the circulatory system, immune responses and metabolic changes. Future research should focus on elucidating the underlying molecular players and on identifying whether the pathways that interconnect gut dysbiosis with ACE are causal, correlational, or consequential. Conclusions: The accumulated evidence supports that the dysbiosis of the intestinal microbiota is involved in the synthesis of proatherogenic metabolites which modulate the mechanisms involved in the pathophysiology of ACE(AU)

Humans , Male , Female , Cardiovascular Diseases/epidemiology , Metabolic Syndrome/epidemiology , Atherosclerosis/epidemiology , Dysbiosis , Gastrointestinal Microbiome/physiology
Rev. chil. neuro-psiquiatr ; 60(1): 13-25, mar. 2022. tab, ilus
Article in Spanish | LILACS | ID: biblio-1388415


INTRODUCCIÓN: Se ha postulado la relación entre la presencia de enfermedades cardiometabólicas con problemas de salud mental, en particular la depresión. OBJETIVOS: Determinar la asociación entre la presencia de enfermedades cardiometabólicas y la presencia de sintomatología depresiva evaluada mediante el cuestionario PHQ-9 en pacientes atendidos en consultorios externos de medicina interna del Hospital Nacional Hipólito Unanue. METODOLOGÍA: Estudio observacional, analítico, transversal. Se definió enfermedad cardiometabólica como la presencia de diabetes mellitus, hipertensión arterial, dislipidemia, y/u obesidad. Se utilizó el cuestionario PHQ-9 para evaluar la presencia de síntomas sugerentes de depresión. Se evaluó la asociación cruda y ajustada a posibles confusores. Para el análisis multivariado se utilizó un modelo de regresión de Poisson para hallar razones de prevalencia con sus respectivos intervalos de confianza al 95%. Se consideró un p<0,05 como estadísticamente significativo. Resultados: Se incluyeron 252 pacientes, de los que 205 (81,4%) presentaron enfermedades cardiometabólicas y 181 (71,9%) presentaron síntomas consistentes con algún grado de depresión. La presencia de enfermedades cardiometabólicas se asoció a síntomas depresivos tanto en el análisis crudo (RPc 1,43; IC 95% 1,08-1,89; p=0,012) como en el ajustado (RPa 1,31; IC 95% 1,00-1,71; p=0,048). Adicionalmente se encontró asociación entre el sexo femenino y sintomatología depresiva (RPa 1,35; IC 95% 1,11-1,63; p=0,002). CONCLUSIONES: La presencia de enfermedades cardiometabólicas se asoció con la presencia de síntomas depresivos en pacientes atendidos en la consulta externa de medicina interna. El abordaje de la salud mental debe ser parte integral del manejo multidisciplinario del paciente con enfermedad cardiometabólica.

INTRODUCTION: It has been postulated the relationship between presence of cardiometabolic diseases with mental health problems, particularly depression. Objectives: To determine the association between cardiometabolic diseases and presence of depressive symptoms, evaluated by PHQ-9 questionnaire, in patients attended at the outpatient clinic of internal medicine service at Hospital Nacional Hipolito Unanue. METHODS: Observational analytical cross-sectional study. Cardiometabolic disease was defined as the presence of diabetes mellitus, high blood pressure, dyslipidemia, and/or obesity. The PHQ-9 questionnaire was used to evaluate the presence of symptoms suggestive of depression. The association was evaluated crude and adjusted for possible confounders. For the multivariate analysis, a Poisson regression model was used to find prevalence ratios with their respective 95% confidence intervals. A p<0.05 was considered statistically significant. RESULTS: 252 patients were included, of which 205 (81,4%) presented cardiometabolic diseases and 181 (71,9%) presented symptoms consistent with some grade of depression. The presence of cardiometabolic diseases was associated with depressive symptoms both in the crude analysis (PRc 1.43; CI 95% 1.08-1.89; p=0.012) and in the adjusted one (PRa 1.31; CI 95% 1.00-1.71; p=0.048). Additionally, an association was found between female sex and depressive symptoms (PRa 1,35; CI 95% 1,11-1,63; p=0,002). CONCLUSIONS: The presence of cardiometabolic diseases was associated with the presence of depressive symptoms in patients seen at the outpatient clinic of internal medicine. The mental health approach should be an integral part of the multidisciplinary management for the patient with cardiometabolic disease.

Humans , Male , Female , Middle Aged , Aged , Cardiovascular Diseases/psychology , Cardiovascular Diseases/epidemiology , Metabolic Syndrome/psychology , Metabolic Syndrome/epidemiology , Depression/epidemiology , Peru , Cross-Sectional Studies , Multivariate Analysis , Surveys and Questionnaires , Diabetes Mellitus/psychology , Diabetes Mellitus/epidemiology , Dyslipidemias/psychology , Dyslipidemias/epidemiology , Hospitals , Hypertension/psychology , Hypertension/epidemiology , Obesity/psychology , Obesity/epidemiology
Arq. bras. cardiol ; 118(1): 68-74, jan. 2022. tab
Article in English, Portuguese | LILACS | ID: biblio-1360106


Resumo Fundamento Apesar da grande proporção de octogenários com embolia pulmonar aguda, há pouca informação indicando a estratégia de manejo ideal, especialmente medidas terapêuticas, como a terapia lítica. Objetivos O número de pacientes idosos diagnosticados com embolia pulmonar aguda aumenta constantemente. Porém, o papel do tratamento trombolítico não está claramente definido entre os octogenários. Nosso objetivo é avaliar a efetividade da terapia lítica em pacientes octogenários diagnosticados com embolia pulmonar. Métodos Cento e quarenta e oito indivíduos (70,3% de mulheres, n=104) com mais de 80 anos foram incluídos no estudo. Os pacientes foram divididos em dois grupos: tratamento trombolítico versus não-trombolítico. As taxas de mortalidade hospitalar e episódios de sangramento foram definidos como desfechos do estudo. Valor de p <0,05 foi considerado como estatisticamente significativo. Resultados A mortalidade hospitalar reduziu significativamente no grupo trombolítico em comparação ao não-trombolítico (10,5% vs. 24,2%; p=0,03). Episódios de sangramento menores foram mais comuns no braço que recebeu o tratamento trombolítico, mas grandes hemorragias não diferiram entre os grupos (35,1% vs. 13,2%, p<0,01; 7% vs. 5,5% p=0,71, respectivamente). O escore de PESI alto (OR: 1,03 IC95%; 1,01-1,04 p<0,01), a terapia trombolítica (OR: 0,15 IC95%; 0,01-0,25, p< 0,01) e níveis altos de troponina (OR: 1,20 IC95%; 1,01-1,43, p=0,03) estiveram independentemente associados a taxas de mortalidade hospitalar na análise de regressão multivariada. Conclusão A terapia trombolítica esteve associada à mortalidade hospitalar reduzida em detrimento do aumento geral das complicações de sangramento em octogenários.

Abstract Background Despite the high proportion of octogenarians with acute pulmonary embolism, there is little information indicating the optimal management strategy, mainly therapeutic measures, such as lytic therapy. Objectives The number of elderly patients diagnosed with acute pulmonary embolism increases constantly. However, the role of thrombolytic treatment is not clearly defined among octogenarians. Our objective is to evaluate the effectiveness of lytic therapy in octogenarian patients diagnosed with pulmonary embolism. Methods One hundred and forty eight subjects (70.3% women, n=104) aged more than eighty years were included in the study. The patients were divided in two groups: thrombolytic versus non-thrombolytic treatment. In-hospital mortality rates and bleeding events were defined as study outcomes. P-value <0.05 was considered as statistical significance. Results In-hospital mortality decreased significantly in the thrombolytic group compared to the non-thrombolytic group (10.5% vs. 24.2% p=0.03). Minor bleeding events were more common in the arm that received thrombolytic treatment, but major hemorrhage did not differ between the groups (35.1% vs. 13.2%, p<0.01; 7% vs. 5.5% p=0.71, respectively). High PESI score (OR: 1.03 95%CI; 1.01-1.04 p<0.01), thrombolytic therapy (OR: 0.15 95%CI; 0.01-0.25, p< 0.01) and high troponin levels (OR: 1.20 95%CI; 1.01-1.43, p=0.03) were independently associated with in-hospital mortality rates in the multivariate regression analysis. Conclusion Thrombolytic therapy was associated with reduced in-hospital mortality at the expense of increased overall bleeding complications in octogenarians.

Humans , Child , Adolescent , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Metabolic Syndrome/epidemiology , Pediatric Obesity/therapy , Body Composition , Weight Loss/physiology , Body Mass Index , Atrial Natriuretic Factor/metabolism
Arq. bras. cardiol ; 118(1): 33-40, jan. 2022. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1360114


Resumo Fundamento A ação do peptídeo natriurético atrial (ANP) na natriurese, diurese e vasodilatação, resistência à insulina, fígado, rim e tecido adiposo pode contribuir para o desenvolvimento metabólico e cardiovascular saudável. Embora o nível circulante de ANP seja reduzido em pacientes com obesidade, sua resposta à perda de peso ainda é pouco explorada em populações pediátricas. Objetivo Avaliar os efeitos das variações do ANP em resposta à intervenção interdisciplinar para perda de peso na Síndrome Metabólica (SMet) e nos riscos cardiometabólicos em adolescentes com obesidade. Métodos 73 adolescentes com obesidade participaram de uma terapia interdisciplinar para perda de peso de 20 semanas, incluindo uma abordagem clínica, nutricional, psicológica e de exercícios físicos. A composição corporal, análises bioquímicas e pressão sanguínea foram avaliadas. A SMet foi classificada de acordo com a Federação Internacional de Diabetes (IDF) (2007). Após o tratamento, os voluntários foram divididos de acordo com os níveis de plasma do ANP aumento (n=31) ou ANP redução (n=19). Resultados Ambos os grupos apresentaram redução significativa de peso corporal, índice de massa corporal (IMC) e circunferências de cintura, pescoço e quadril (CC, CP e CQ, respectivamente), e aumento da massa livre de gordura (MLG). É interessante observar que houve uma redução significativa na gordura corporal, na razão de TG/HDL-c e na prevalência de SMet (de 23% para 6%) somente no grupo com ANP aumento. Conclusão Este estudo sugere que o aumento nos níveis séricos de ANP após a terapia para perda de peso pode estar associado a melhorias nos riscos cardiometabólicos e na prevalência reduzida de SMet em adolescentes com obesidade.

Abstract Background The action of atrial natriuretic peptide (ANP) on natriuresis, diuresis and vasodilatation, insulin resistance, liver, kidney, and adipose tissue may contribute to the healthy metabolic and cardiovascular development. Even though the circulating level of ANP is reduced in patients with obesity, its response to weight loss remains poorly explored in pediatric populations. Objective To evaluate the effects of ANP variations in response to interdisciplinary weight loss intervention on metabolic syndrome (MetS) and cardiometabolic risks in adolescents with obesity. Methods 73 adolescents with obesity attended a 20-week clinical interdisciplinary weight loss therapy including clinical, nutritional, psychological and exercise training approach. Body composition, biochemical analyses and blood pressure were evaluated. MetS was classified according to the International Diabetes Federation (IDF) (2007). After the treatment, volunteers were divided according to Increasing (n=31) or Decreasing (n=19) ANP plasma levels. Results Both groups present significant reduction of body weight, Body Mass Index (BMI), waist, neck and hip circumferences (WC, NC and HC, respectively) and increasing fat-free mass (FFM). Interestingly, a significant reduction in body fat, TG/HDL-c ratio and MetS prevalence (from 23% to 6%) was observed in the Increased ANP group only. Conclusion This study suggests that an increase in ANP serum levels after weight loss therapy could be associated with improvements in cardiometabolic risks and the reduced prevalence of MetS in adolescents with obesity.

Humans , Child , Adolescent , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Metabolic Syndrome/epidemiology , Pediatric Obesity/therapy , Body Composition , Weight Loss/physiology , Body Mass Index , Atrial Natriuretic Factor/metabolism
Rev. chil. endocrinol. diabetes ; 15(4): 138-144, 2022. tab
Article in Spanish | LILACS | ID: biblio-1437500


INTRODUCCIÓN: la diabetes mellitus gestacional (DMG) es una complicación común del embarazo siendo su prevalencia muy variable según la población estudiada y los criterios diagnósticos empleados. Sabemos que la DMG se asocia con un aumento de numerosas complicaciones a nivel materno-fetal, así como a un aumento del riesgo de DMG en futuros embarazos y de diabetes tipo 2 a largo plazo. Objetivos: nuestro objetivo es investigar de forma retrospectiva la evolución a largo plazo (9 años) de las 225 pacientes diagnosticadas de DMG en el Hospital Severo Ochoa en el año 2013 en el screening prenatal. Determinar la incidencia a largo plazo de alteración del metabolismo hidrocarbonado (AMH) y su relación con parámetros clínicos y bioquímicos en la gestación. Métodos: se ha realizado la revisión de Historias Clínicas informatizadas en el programa Selene y en papel del archivo hospitalario. Se han revisado las analíticas en los programas infinity/ Omega y la evolución en el programa Horus de Atención Primaria. Se ha revisado los tratamientos en el módulo de prescripción única (MUP). Conclusiones: la incidencia de AMH en nuestra serie a 9 años de seguimiento es del 22%. El porcentaje de screening postparto es bajo (41%). Los factores asociados independientemente con el desarrollo de AMH son la glucemia basal en el screening, la existencia de obesidad pregestacional y la aparición de trastornos hipertensivos durante la gestación.

INTRODUCTION: gestational diabetes mellitus (GDM) is a common complication of pregnancies with a variable prevalence depending on the studied population and the diagnostic criteria used. We know that GDM is associated to numerous complications for the mother and the baby as well as a higher risk of GDM in future pregnancies and type 2 diabetes on the long term. Objective: our objective is to investigate retrospectively the long term (9 years) evolution of 225 patients diagnosed with GDM in the Hopital Severo Ochoa along 2013 in the prenatal screening. To determinate the long term incidence of hydrocarbonate metabolism alterations (HMA) and its relationship with clinical and biochemical parameters in the pregnancy. Methods: we have search the Medical Records computerized in the Selene program and in paper in the hospital Archives. The analyses in the programs Infinity and Omega have been reviewed as well as the clinical evolution in the Primary Care program Horus. The actual treatments have been searched in the Madrid system of electronical prescription (MUP). Conclusions: HMA incidence in our patients series is 22% at 9 years. After delivery the screening is low (41%). Basal glucose at screening during pregnancy, pregestational obesity and the ocurrence of hypertensive alterations during pregnancy were the independent factors associated to HMA at long term.

Humans , Female , Pregnancy , Adult , Diabetes, Gestational , Metabolic Syndrome/epidemiology , Postpartum Period , Time Factors , Logistic Models , Retrospective Studies , Follow-Up Studies
Esc. Anna Nery Rev. Enferm ; 26: e20210321, 2022. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1384926


RESUMO Objetivo Identificar os principais fatores de risco para a síndrome metabólica e sua relação com a percepção da qualidade de vida em colônias pesqueiras brasileiras. Métodos Incluímos 77 participantes com idade > 18 anos. Síndrome metabólica e qualidade de vida foram os principais desfechos do estudo. Consideramos nível de significância < 0,05 e todos os procedimentos foram aprovados pelo comitê de ética. Resultados A maioria dos participantes é do sexo masculino, solteiros, classe econômica D-E, carga horária trabalhada de 6 a 8 horas, tempo de serviço de 1 a 5 anos e dedicados exclusivamente à pesca. Conclusão: Perímetro abdominal e pressão arterial foram os critérios mais frequentes e de maior contribuição para a síndrome metabólica. Apesar de a qualidade de vida apresentar maior escore para o domínio relações sociais, neste estudo, o domínio físico foi o único associado a outra observação, na qual observamos correlação significativa com a pressão arterial sistólica.

RESUMEN Objetivo Identificar los principales factores de riesgo del síndrome metabólico y su relación con la percepción de la calidad de vida en las colonias pesqueras brasileñas. Métodos se incluyeron 77 participantes mayores de 18 años. El síndrome metabólico y la calidad de vida fueron los principales resultados del estudio. Se consideró un nivel de significancia <0.05 y todos los procedimientos fueron aprobados por el comité de ética. Resultados La mayoría de los participantes son hombres, solteros, clase económica D-E, jornada laboral de 6 a 8 horas, antigüedad de 1 a 5 años y dedicados exclusivamente a la pesca. Conclusión La circunferencia de la cintura y la presión arterial fueron los criterios más frecuentes y la mayor contribución al síndrome metabólico. Aunque la calidad de vida tuvo una puntuación más alta para el dominio de relaciones sociales, en este estudio, el dominio físico fue el único asociado con otra observación, en la que observamos una correlación significativa con la presión arterial sistólica.

ABSTRACT Objective To identify the main risk factors for metabolic syndrome and its relationship with the perception of quality of life in Brazilian fishing colonies. Methods We included 77 participants aged > 18 years. Metabolic syndrome and quality of life were the main study outcomes. We considered a significance level < 0.05 and all procedures were approved by the ethics committee. Results Most participants are male, single, economic class D-E, working hours of 6 to 8 hours, length of service from 1 to 5 years, and dedicated exclusively to fishing. Conclusion Abdominal perimeter and blood pressures were the most frequent criteria and the greatest contribution to metabolic syndrome. Although quality of life had a higher score for the social relationship domain, in this study, the physical domain was the only one associated with another observation, in which we observed a significant correlation with systolic blood pressure.

Humans , Male , Female , Quality of Life , Health Profile , Occupational Health/statistics & numerical data , Metabolic Syndrome/epidemiology , Vulnerable Populations , Socioeconomic Factors , Triglycerides/blood , Blood Glucose , Body Weight , Brazil/epidemiology , Biomarkers/blood , Body Mass Index , Prevalence , Cross-Sectional Studies , Risk Factors , Arterial Pressure , Hunting , Cholesterol, HDL/blood
Rev. latinoam. enferm. (Online) ; 30: e3579, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1389120


Resumo Objetivo: avaliar a associação da Síndrome Metabólica e dos seus componentes entre os profissionais de Enfermagem da Atenção Primária à Saúde do estado da Bahia, Brasil, segundo a categoria profissional. Método: estudo transversal, populacional e multicêntrico conduzido com 1.125 profissionais de Enfermagem. A variável independente foi a categoria profissional, dicotomizada em nível técnico e superior de ensino. O desfecho foi a Síndrome Metabólica seguindo os critérios da National Cholesterol Education Program Adult Treatment Panel III, a partir de aferições antropométricas e de amostras sanguíneas. A análise estatística deu-se pelo cálculo das razões de prevalência e pelo Teste Qui-quadrado de Pearson. Resultados: a prevalência da Síndrome Metabólica foi maior na categoria de nível técnico (RP=1,64; IC 1,29 - 2,06; p≤0,01). Estes profissionais quando comparados com os Enfermeiros eram mais velhos, tinham renda inferior, trabalhavam mais em regime de plantão e realizavam menos atividades físicas de maneira regular. Entre Enfermeiros, o componente mais prevalente foi o colesterol alterado (40,5%); entre Técnicos de Enfermagem/Auxiliares, a obesidade abdominal (47,3%). Conclusão: ficou evidente a associação entre categoria de Enfermagem e Síndrome Metabólica, cuja ocorrência foi maior entre profissionais de nível técnico.

Abstract Objective: to evaluate the association of Metabolic Syndrome and its components among Primary Health Care Nursing professionals in the state of Bahia, Brazil, according to professional category. Method: a cross-sectional, population-based and multicenter study conducted with 1,125 Nursing professionals. The independent variable was the professional category, dichotomized into technical and higher education levels. The outcome was Metabolic Syndrome following criteria from the National Cholesterol Education Program Adult Treatment Panel III based on anthropometric measurements and blood samples. The statistical analysis was performed by calculating the prevalence ratios and using Pearson's Chi-square test. Results: the prevalence of Metabolic Syndrome was higher in the technical level category (PR=1.64; CI=1.29 - 2.06; p≤0.01). When compared to Nurses, these professionals were older, had lower incomes, worked more on duty and performed less physical activity on a regular basis. Among the Nurses, the most prevalent component was altered cholesterol (40.5%) and among the Nursing Technicians/Assistants, it was abdominal obesity (47.3%). Conclusion: the association between the Nursing category and Metabolic Syndrome was evident, with higher occurrence among technical level professionals.

Resumen Objetivo: evaluar la asociación que hay entre el Síndrome Metabólico y sus componentes y los profesionales de Enfermería de la Atención Primaria de Salud en el estado de Bahía, Brasil, según la categoría profesional. Método: estudio transversal, de base poblacional y multicéntrico realizado con 1.125 profesionales de Enfermería. La variable independiente fue la categoría profesional, dicotomizada en niveles de educación técnica y superior. El resultado fue Síndrome Metabólico siguiendo los criterios del National Cholesterol Education Program Adult Treatment Panel III a partir de mediciones antropométricas y muestras de sangre. El análisis estadístico se realizó calculando las razones de prevalencia y utilizando la prueba de Chi-cuadrado de Pearson. Resultados: la prevalencia de Síndrome Metabólico fue mayor en la categoría de nivel técnico (RP=1,64; IC 1,29 - 2,06; p≤0,01). Dichos profesionales tenían mayor edad, menor ingreso, más guardias y realizaban menos actividad física de forma regular que los Enfermeros. En los Enfermeros, el componente más prevalente fue el colesterol alterado (40,5%); en los Técnicos en Enfermería/Auxiliares fue la obesidad abdominal (47,3%). Conclusión: fue evidente la asociación entre la categoría de Enfermería y el Síndrome Metabólico, fue mayor en los profesionales de nivel técnico.

Humans , Male , Female , Adult , Brazil/epidemiology , Prevalence , Occupational Health , Metabolic Syndrome/epidemiology , Nursing, Team
Rev. cuba. med. gen. integr ; 38(3): e1909, 2022.
Article in Spanish | LILACS, CUMED | ID: biblio-1408721


Introducción: El síndrome metabólico constituye un hito en la investigación de evaluar mejor y de manera óptima el riesgo de enfermedad cardiovascular aterosclerótica. Objetivo: Analizar la correlación entre la capacidad predictiva del riesgo global de enfermedad cardiovascular aterosclerótica del síndrome metabólico y las tablas de riesgo: Framingham Risk Score, la tabla de la OMS/ISH y las de Gaziano, la ecuación PROCAM y el algoritmo QRISK2. Métodos: Se realizó una revisión documental, para lo cual se empleó la bibliografía nacional e internacional, especialmente la publicada en los últimos 5 años. Se utilizó el motor de búsqueda Google Académico y se consultaron artículos de libre acceso en las bases de datos Pubmed y SciELO desde marzo 2020 hasta el mes de enero 2021. Se emplearon como palabras clave: síndrome metabólico, riesgo cardiovascular global, método de estimación de riesgo y sus equivalentes en inglés. Las unidades de análisis fueron artículos originales, de revisión, incluyendo revisiones sistemáticas publicadas en los idiomas español e inglés. Fueron seleccionados 38 artículos (23 en idioma español, 15 en inglés) y 31 (81,5 por ciento) corresponden a los últimos 5 años. Conclusiones: El síndrome metabólico y los sistemas de estimación del riesgo global de enfermedad cardiovascular aterosclerótica no deben ser utilizados como equivalentes a causa de que su concordancia, en sentido general, es muy cuestionable. No obstante, se puede considerar como una herramienta útil en prevención primaria de la enfermedad cardiovascular aterosclerótica, siempre y cuando no sustituyan el juicio clínico y se contemplen todas las excepciones y precauciones posibles en el momento de su aplicación(AU)

Introduction: Metabolic syndrome is a milestone within the research to assess better and optimally the risk of atherosclerotic cardiovascular disease. Objective: To analyze the correlation between the predictive capacity for the global risk of atherosclerotic cardiovascular disease of metabolic syndrome and the risk tables: Framingham Risk Score, the WHO/ISH and Gaziano tables, the PROCAM equation, and the QRISK2 algorithm. Methods: A documentary review was carried out, using national and international literature, especially published within the last five years. The Google Scholar search engine was used and open-access articles were consulted in the Pubmed and SciELO databases, from March 2020 to January 2021. The keywords used were síndrome metabólico [metabolic syndrome], riesgo cardiovascular global [global cardiovascular risk], método de estimación de riesgo [risk estimation method] and their English equivalents. The units of analysis were original review articles, including systematic reviews published in Spanish and English. Thirty-eight articles were selected (23 in Spanish and fifteen in English), 31 (81.5 percent) of which correspond to the last five years. Conclusions: Metabolic syndrome and global risk estimation systems for atherosclerotic cardiovascular disease should not be used as equivalents because their concordance, in general, is very questionable. Nevertheless, they can be considered a useful tool in the primary prevention of atherosclerotic cardiovascular disease, as long as they do not replace clinical judgment and all possible exceptions or precautions are considered at the time of their application(AU)

Humans , Male , Female , Middle Aged , Global Health , Metabolic Syndrome/epidemiology , Atherosclerosis/prevention & control , Heart Disease Risk Factors , Algorithms , Health Status Indicators , Risk Assessment/methods
Chinese Journal of Epidemiology ; (12): 387-391, 2022.
Article in Chinese | WPRIM | ID: wpr-935400


Objective: To estimate the incidence of metabolic syndrome and explore possible risk factors for metabolic syndrome in adults of rural communities in Yuhuan county, Zhejiang province, China. Methods: During June-December, 2018, a follow-up survey was conducted in participants without metabolic syndrome at baseline survey in 2012 to obtain the information collected in questionnaire survey, anthropometric data and laboratory data. The incidence of metabolic syndrome in the participants was estimated, and Logistic regression model was used to explore the risk factors, adjusted risk ratio (aRR) and 95%CI. Results: Among 3 162 participants, 522 new metabolic syndrome cases were identified. The 6-year cumulative incidence rate of metabolic syndrome was 16.5%, and the cumulative incidence rate was higher in women (20.6%) than that in men (12.3%, P<0.001). Those incidence rates were higher in those in jobless, smoking or drinking groups. Being women (aRR=1.96, 95%CI: 1.50-2.58) and family history of hypertension (aRR=1.31, 95%CI: 1.04-1.63) were independent risk factors for metabolic syndrome. Conclusion: The follow up indicated that the incidence of metabolic syndrome was relatively high in rural adults on islands in Zhejiang, and women or those with family history of hypertension were more likely to have metabolic syndrome.

Adult , Female , Humans , Male , Incidence , Islands , Metabolic Syndrome/epidemiology , Risk Factors , Rural Population
Article in Chinese | WPRIM | ID: wpr-935351


Objective: To examine the associations between metabolic syndrome (MS) and the risks for impaired activities of daily living (ADL) in the middle-aged and elderly population in China and provide basis for improving healthy life expectancy. Methods: Prospective cohort study design was used in this study. Based the data of China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018 and the baseline data in 2011, the follow up for ADL outcomes was conducted in 2013, 2015 and 2018 respectively, and the participants recruited in 2013 and 2015 were new baseline populations. The participants with impaired ADL in three baseline populations were excluded. Cox proportional hazard model was used to estimate the effect of different components and number of MS components on the risk for ADL impairment in the middle-aged and elderly population in China. Results: In 59 795 person-years of follow-up, a total of 1 011 cases of ADL impairments were recorded. The incidence density of ADL impairment was 16.91 per 1 000 person-year; The findings of Cox regression analysis showed that compared with the middle aged and elderly people without MS, the risk for ADL impairments was 1.29 times higher (95%CI: 1.12-1.50) for those with one component of MS, 1.32 times higher (95%CI:1.07-1.64) for those with hyperlipemia complicated with diabetes, 1.78 times higher (95%CI: 1.22-2.59) for those with obesity and one component of MS, 2.48 times higher (95%CI:1.59-3.85) for those with hypertension complicated with hyperlipemia, 3.51 times higher (95%CI:1.66-7.43) for those with hypertension complicated with diabetes, 1.80 times higher (95%CI: 1.40-2.32) for those with ≥3 MS, respectively. Compared with the middle-aged and elderly population without MS, the risk for impaired ADL increased by 30% (HR=1.30, 95%CI: 1.13-1.51), 54% (HR=1.54, 95%CI: 1.28-1.85) and 87% (HR=1.87, 95%CI:1.45-2.41), respectively, in the middle-aged and elderly with one, two, and more than three components of MS, with a significant dose-response relationship that ADL impaired risks increased as the number of MS components increased (P<0.001). Conclusions: Our findings suggested that MS is a risk factor for ADL impairment in middle-aged and elderly population in China. Prevention and early intervention of obesity, hypertension, hyperlipemia, diabetes and metabolic syndrome could help to reduce or delay the incidence of ADL impairment.

Aged , Humans , Middle Aged , Activities of Daily Living , China/epidemiology , Longitudinal Studies , Metabolic Syndrome/epidemiology , Prospective Studies
Chinese Journal of Epidemiology ; (12): 533-540, 2022.
Article in Chinese | WPRIM | ID: wpr-935423


Objective: To study the prevalence and associated factors of metabolic syndrome (MS) among Tibetan pastoralists in transition from high altitude nomadic to settled urbanized environment, especially dietary factors. Methods: The community-based cross-sectional study included 920 Tibetan adults (men 419, women 501). Data were collected using questionnaires, anthropometric measurements, and biomarker tests. Questionnaires included socio-economic, lifestyle characteristics and food consumption. Principal component analysis was used to identify dietary patterns. The risk factors of MS and its components were analyzed by logistic regression model. Results: The prevalence rates of MS and its components were 32.8% (MS), 83.7% (decreased HDL-C), 62.1% (central obesity), 36.7% (elevated blood pressure), 11.8% (elevated TG), and 7.9% (elevated blood glucose), respectively. The prevalence of overweight was 31.2%, obesity 30.3%. Multivariate analysis showed smoking was associated factor for both of decreased HDL-C (OR=1.239, 95%CI: 1.025-1.496) and elevated TG (OR=1.277, 95%CI: 1.038-1.571). Alcohol drinking appeared as associated factor of elevated TG (OR=1.426, 95%CI: 1.055-1.927). However, physical activity showed as a protective factor for central obesity, decreased HDL-C, and elevated TG. With the increase of age, the adherence to the urban and western dietary patterns decreased, and that to the pastoral dietary pattern increased. By quintiles of dietary pattern scores, the urban dietary pattern was significantly associated with MS (trend test P=0.016). Conclusions: Tibetan pastoralists had high prevalence of both MS and obesity. Smoking, alcohol drinking, the transition from pastoral dietary pattern to urban dietary pattern and inadequate physical activity served as associated factors for MS and its components.

Adult , Female , Humans , Male , Cross-Sectional Studies , Metabolic Syndrome/epidemiology , Obesity/epidemiology , Obesity, Abdominal , Prevalence , Risk Factors , Tibet/epidemiology
Article in Spanish | LILACS, CUMED | ID: biblio-1408656


Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world, representing the hepatic component of metabolic syndrome, and currently affects an average of 20-33 percent of the adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD and is a consequence of overweight, obesity, and metabolic syndrome. Objective: The study aimed to evaluate the effectiveness of the use of freeze-dried mare's milk in NASH. Methods: Clinical-biochemical, ultrasound, and fibroelastometric research methods were used in NASH patients receiving mare's milk in comparison with the control groups. Results: The result of the study demonstrates noticeable gain not only in the clinical symptoms of the disease but also in the laboratory and instrumental indicators, as well as health improvement and a decrease in symptoms of concomitant pathology. Taking mare's milk not only normalized liver biochemical parameters but also decreased cholesterol metabolism (total cholesterol, LDL, TG), the degree of liver steatosis, and existing hepatomegaly declined too. This pleiotropic effect of mare's milk points to the pathogenetic feasibility for the use of Saumal in NAFLD, including NASH. Conclusions: Addressing the problems of healthy nutrition in NASH, mare's milk can be considered as a pathogenetically justified, highly effective, and affordable natural therapeutic and prophylactic agent. The value of the product is determined by its multicomponent balanced qualitative composition. Hepatoprotective, hypocholesterolemic, and lipotropic properties of mare's milk in this pathology are marked(AU)

Introducción: La enfermedad del hígado graso no alcohólico es la enfermedad hepática más común en el mundo, representa el componente hepático del síndrome metabólico y actualmente afecta a un promedio de 20 a 33 por ciento de la población adulta. La esteatohepatitis no alcohólica es una forma grave de hígado graso no alcohólico y es una consecuencia del sobrepeso, la obesidad y el síndrome metabólico. Objetivo: Evaluar la efectividad del uso de leche de yegua liofilizada en hígado graso no alcohólico. Métodos: Se utilizaron métodos de investigación clínico-bioquímicos, ecográficos y fibroelastométricos en pacientes con hígado graso no alcohólico que recibieron leche de yegua en comparación con los grupos de control. Resultados: El resultado del estudio demuestra una ganancia notable no solo en los síntomas clínicos de la enfermedad, sino también en los indicadores de laboratorio e instrumentales, así como una mejora de la salud y una disminución de los síntomas de la enfermedad concomitante. La ingesta de leche de yegua no solo normalizó los parámetros bioquímicos del hígado, sino que también disminuyó el metabolismo del colesterol (colesterol total, LDL, TG), el grado de esteatosis hepática y la hepatomegalia existente también disminuyeron. Este efecto pleiotrópico de la leche de yegua apunta a la viabilidad patogénica del uso de Saumal en hígado graso no alcohólico, incluida la esteatohepatitis no alcohólica. Conclusión: Al abordar los problemas de una nutrición saludable en la enfermedad hígado graso no alcohólico, la leche de yegua se puede considerar como un agente terapéutico y profiláctico natural patogénicamente justificado, altamente efectivo y asequible. El valor del producto está determinado por su composición cualitativa equilibrada multicomponente. Las propiedades hepatoprotectoras, hipocolesterolémicas y lipotrópicas de la leche de yegua en esta enfermedad son marcadas(AU)

Humans , Male , Female , Ultrasonography/methods , Metabolic Syndrome/epidemiology , Non-alcoholic Fatty Liver Disease/epidemiology
Rev. bras. hipertens ; 28(4): 261-268, 10 dez. 2021.
Article in Portuguese | LILACS | ID: biblio-1367449


As Doenças Cardiovasculares (DCV) são alterações nos vasos sanguíneos decorrentes, principalmente, da aterosclerose, e representam 28% dos óbitos anuais no Brasil. Em 2013, a prevalência de DCV era de 4,2% na população adulta e 11,4% nos idosos. A Síndrome Metabólica (SM), cuja prevalência é estimada entre 25 e 30%, é um dos principais fatores de risco para a instalação das DCV, assim como a Rigidez Arterial (RA), determinada pela Velocidade de Onda de Pulso (VOP) alterada. O Sistema Sphygmocor é utilizado para mensuração da VOP através da razão entre enrijecimento arterial, elasticidade e complacência vascular, considerando valores normais aqueles abaixo de 10m/s. A VOP foi o método de escolha, junto a medidas antropométricas e exames laboratoriais, para avaliar a prevalência de SM e RA numa amostra populacional de Salvador, Bahia. O teste T de Student foi utilizado para comparar as variáveis e o teste Qui Quadrado, para comparar as proporções das variáveis qualitativas. O cálculo das prevalências foi realizado com o número de indivíduos com RA ou SM no numerador e o número total da amostra no denominador, com resultado multiplicado por 102 . O estudo foi aprovado pelo Comitê de Ética em Pesquisa através do parecer número 1.827.621 de 21 de novembro de 2016. A amostra de 162 participantes demonstrou prevalência de 25,93% de Síndrome Metabólica e 26,57% de Rigidez Arterial, expondo a importância de maior atenção à prevenção das DCV na atenção primária à Saúde.

Cardiovascular Diseases (CVD) are modifications in blood vessels resulting mainly from atherosclerosis and represent 28% of annual deaths in Brazil. In 2013, the prevalence of CVD was 4.2% in the adult population and 11.4% in the elderly. Metabolic Syndrome (MS), whose prevalence is estimated between 25 and 30%, is one of the main risk factors for the settlement of CVD, as well as Arterial Stiffness (AS), determined by altered Pulse Wave Velocity (PWV). The Sphygmocor System is used to measure PWV through the ratio between arterial stiffening, elasticity, and vascular complacency, considering normal valor those below 10m/s. PWV was the method of choice, with anthropometric measurements and laboratory tests, to evaluate the prevalence of MS and AS in a population sample from Salvador, Bahia. The Student's T test was used to compare the variables and the Chi Square test to compare the proportions of the qualitative variables. The calculation of prevalence was made with the number of individuals with AS or MS in the numerator and the total number of sample in the denominator, with the result multiplied by 102. The study was approved by the Research Ethics Committee through opinion number 1,827,621 of November 21, 2016. The sample of 162 participants showed a prevalence of 25.93% of Metabolic Syndrome and 26.57% of Arterial Stiffness, exposing the importance of greater attention to the prevention of CVD in primary health care.

Humans , Male , Female , Adult , Middle Aged , Aged , Prevalence , Metabolic Syndrome/epidemiology , Vascular Stiffness , Heart Disease Risk Factors