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1.
Bol. micol. (Valparaiso En linea) ; 36(2): 12-14, dic. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1352554

ABSTRACT

Los ácaros ectoparásitos del género Demodex spp (>140 especies) pertenecen a la familia Demodicidae, superfamilia Cheyletoidea, suborden Prostigmata, orden Trombidiformes, superorden Acariformes. Fueron descritos por primera vez en 1841 por Henle y Berger. El término Demodex deriva del griego: demos = grasa y dex = gusano incrustado. Tienen una longitud de 0.2- 0.4 mm, son transparentes y elongados. Su cuerpo se divide en tres secciones principales: 1) gnatosoma, región anterior, en donde se encuentra la apertura bucal; 2) podosoma, región en la que se encuentran sus cuatro pares de patas; y 3) el opistoma, región caudal o cola. Se adquieren poco después del nacimiento y se consideran parte del microbiota normal de muchos mamíferos, así como también del ser humano, en particular de la unidad pilosebácea. Por lo tanto, se ubican principalmente en el rostro, cuero cabelludo y región superior del tronco. Todas estas áreas corporales se caracterizan por la alta secreción sebácea, alimento primordial para el crecimiento y desarrollo de este ácaro; razón por la cual, además, su densidad aumenta durante la pubertad, periodo cuando proliferan las glándulas sebáceas. Dentro de las especies del género, encontramos exclusivamente en humanos, a D. folliculorum (440 µm), habitando frecuentemente el infundíbulo folicular y D. brevis (240 µm), que se localiza predominantemente en los ductos sebáceos y glándulas tarsales a nivel ocular.(AU)


Subject(s)
Humans , Mite Infestations/diagnosis , Mite Infestations/parasitology , Metronidazole/administration & dosage , Mite Infestations/drug therapy
2.
Rev. argent. cir ; 112(3): 311-316, jun. 2020. graf
Article in Spanish | LILACS | ID: biblio-1279744

ABSTRACT

RESUMEN La técnica PIPAC se presenta como una variante de tratamiento para los pacientes con carcinomato sis peritoneal que no son candidatos a una resección. Se describen de manera detallada los pasos y el procedimiento quirúrgico para la administración de quimioterapia intraperitoneal presurizada con dispositivo PIPAC.


ABSTRACT Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a therapeutic option for patients with unresectable peritoneal carcinomatosis. The steps and the surgical technique of the PIPAC technique are thoroughly described.


Subject(s)
Drug Therapy/methods , Peritoneal Neoplasms/surgery , Peritoneal Neoplasms/drug therapy , Cefuroxime/administration & dosage , Aerosols , Laparoscopes , Metronidazole/administration & dosage
3.
Braz. J. Vet. Res. Anim. Sci. (Online) ; 57(2): e166204, mai. 2020. ilus, graf
Article in English | LILACS, VETINDEX | ID: biblio-1122176

ABSTRACT

Medical management of abdominal abscesses in horses requires prolonged antibiotic therapy and presents varied success rates. A 6-year-old male horse with a history of colic and multiple abdominal punctures to relieve gas was attended. At admission, tachycardia, tachypnea, hyperthermia, mucosal congestion, dehydration, and rigid gait were observed. The association of physical examination, laboratory and ultrasonographic findings allowed the diagnoses of peritonitis and abdominal abscess. Supporting treatment plus broad spectrum antibiotic therapy was performed: daily intraperitoneal ceftriaxone (25 mg/kg, 7 days); daily intravenous gentamicin (6.6 mg/kg, 7 days); per os metronidazole three times a day (15 mg/kg 12 days), followed by the same dose twice a day (15 mg/kg 33 days), totaling 45 days of treatment. Plasma fibrinogen and ultrasonographic examination were the most effective tools to evaluate abscess evolution. There was normalization of the physical examination 24 h after beginning the treatment, consecutive regression of the nucleated cell count in the peritoneal fluid, and regression of plasma fibrinogen and size of the abscess. On the 10th treatment day, the animal was discharged from the hospital, maintaining oral therapy with metronidazole every 12 h (15 mg / kg). When the animal returned on the 30th day, an abscess size regression was observed. However, there was no resolution, and therapy with metronidazole was maintained. On the 45th day of treatment, a new hospital evaluation was performed, where the abscess resolved, and metronidazole was suspended. It is highlighted that the therapeutic association used in the treatment of abdominal infection and abscess resulted in a rapid clinical response.(AU)


O tratamento conservativo dos abscessos abdominais em equinos requer antibioticoterapia prolongada e apresenta variadas taxas de sucesso. Foi atendido um cavalo de seis anos de idade, com histórico de cólica e múltiplas punções abdominais por agulha para esvaziamento de gás. Na admissão, foram observados taquicardia, taquipnéia, hipertermia, congestão mucosa, desidratação e marcha rígida. A associação do exame físico, achados laboratoriais e ultrassonográficos permitiu o diagnóstico de peritonite e abscesso abdominal. Foi realizado tratamento suporte e antibioticoterapia de amplo espectro: ceftriaxona intraperitoneal diária (25 mg/kg, 7 dias); gentamicina intravenosa diária (6,6 mg/kg, 7 dias); metronidazol oral três vezes ao dia (15 mg/kg, 12 dias), seguido de mesma dose duas vezes ao dia, por mais 33 dias, totalizando 45 dias de tratamento. O fibrinogênio plasmático e o exame ultrassonográfico foram os recursos mais eficazes para a avaliação da evolução do abscesso. Após 24 horas do início do tratamento foi constatada a normalização do exame fisico, regressão progressiva da contagem de células nucleadas no líquido peritoneal, do fibrinogênio plasmático e do tamanho do abscesso. No 10° dia de tratamento o animal recebeu alta hospitalar, mantendo-se a terapia oral com metronidazol a cada 12 horas (15 mg/Kg). Em retorno, ao 30° dia, observou-se regressão do tamanho do abscesso, entretanto, não houve resolução, tendo sido mantida a terapia com metronidazol. No 45º dia de tratamento, realizou-se nova avaliação hospitalar, onde foi observada a resolução do abscesso e a admnistração do metronidazol foi suspensa. Destaca-se, que a associação terapêutica utilizada no tratamento de infecção abdominal e abscesso resultou em rápida resposta clínica.(AU)


Subject(s)
Animals , Peritonitis/veterinary , Ceftriaxone/administration & dosage , Gentamicins/administration & dosage , Abdominal Abscess/veterinary , Horses , Metronidazole/administration & dosage , Ultrasonics , Fibrinogen , Injections, Intraperitoneal/veterinary
4.
Acta cir. bras ; 34(1): e20190010000004, 2019. tab, graf
Article in English | LILACS | ID: biblio-983681

ABSTRACT

Abstract Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model. Methods: An open skin wound, 2 cm in diameter and total skin thickness was prepared, under anesthetic, in the dorsal region of 108 Wistar rats weighing between 300 and 350 grams. The animals were allocated to groups of 18 animals in accordance with the concentration of metronidazole in the solution to be applied daily to the wound. In the control group (CG), 0.9% sodium chloride solution was used for application, and in the experimental groups (GI, GII, GIII, GIV and GV) metronidazole solution at 4%, 6%, 8%, 10% and 12%, respectively, was applied. After 3, 7 and 14 days of treatment. Blood samples collected through cardiac puncture were examined for the existence or non-existence of metronidazole, using high performance liquid chromatography (HPLC). Detected metronidazole values were compared statistically within each group (temporal analysis 3 days X 7 days X 14 days) and between the groups that used topical metronidazole (4% X 6% X 8% X 10% and 12%) using the Kruskal-Wallis test, considering a statistical significance of 95% (p<0.05). Results: Metronidazole was detected in all the samples at all times in all the groups in which topical metronidazole was applied to the wounds. Characteristically, there was no significant difference between the doses obtained within each group over time (3 days X 7 days X 14 days) GI=0.461; GII=0.154; GIII=0.888; GIV= 0.264 and GV=0.152. In the evaluation between groups, a similar degree of absorption was found after 3 days (p=0.829) and 14 days (p=0.751). Conclusion: The serum concentration of metronidazole that was achieved was not influenced by the concentration of the solution applied to the skin wound, with similar extend, or by the duration of the application.


Subject(s)
Animals , Male , Rats , Wound Healing/drug effects , Metronidazole/administration & dosage , Metronidazole/blood , Anti-Infective Agents/administration & dosage , Anti-Infective Agents/blood , Time Factors , Administration, Topical , Chromatography, Liquid , Rats, Wistar , Disease Models, Animal
6.
Rev. Col. Bras. Cir ; 46(1): e2015, 2019. tab, graf
Article in Portuguese | LILACS | ID: biblio-990367

ABSTRACT

RESUMO Objetivo: avaliar os efeitos da administração tópica do metronidazol na diferenciação de fibroblastos e na contração da ferida durante cicatrização experimental por segunda intenção em ratos. Métodos: cento e oito animais foram submetidos a uma ferida circular no dorso, com 2cm de diâmetro e divididos em seis grupos: grupo controle, com aplicação de solução salina sobre a ferida e cinco grupos experimentais divididos de acordo com a concentração da solução do metronidazol utilizada (4%, 6%, 8%,10% e 12%). Curativos foram realizados diariamente durante todo o período do experimento, que foi subdividido em três momentos de análise: três, sete e 14 dias. A contração da ferida foi avaliada por planimetria digital e os miofibroblastos e protomiofibroblastos foram identificados usando técnicas de imuno-histoquímica CD34 e a-SMA. Resultados: a contração da ferida não apresentou diferença entre os grupos e o controle. Os protomiofibroblastos foram significativamente mais numerosos aos sete dias (p=0,022) nos grupos metronidazol de 4%, 6% e 8%. Após 14 dias, nos mesmos grupos, os miofibroblastos predominaram significativamente (p=0,01). Conclusão: a administração tópica de solução de metronidazol em feridas de pele com cicatrização por segunda intenção foi capaz de melhorar a diferenciação de fibroblastos. A fase de contração da cicatrização de feridas permaneceu inalterada, sem redução significativa da contração avaliada pela planimetria digital. Estes resultados podem ser utilizados em favor do processo de cicatrização de feridas.


ABSTRACT Objective: to assess the effects of topical administration of metronidazole on fibroblast differentiation and on wound contraction during experimental secondary intention wound healing in rats. Methods: we submitted 108 rats to a circular wound on the back, 2cm in diameter, and divided them into six groups: control group, with application of saline solution on the wound and five experimental groups, divided according to the concentration of metronidazole solution used (4%, 6%, 8%, 10% and 12%). We changed the dressings daily throughout the trial period, which comprised three stages of analysis: three, seven and 14 days. We evaluated wound contraction by digital planimetry, and identified myofibroblasts and protomyofibroblasts using CD34 and α-SMA immunohistochemistry techniques. Results: wound contraction was not different between the experimental and the control groups. Protomyofibroblasts were significantly more numerous at seven days (p=0.022) in the 4%, 6% and 8% metronidazole groups. After 14 days, in the same groups, myofibroblasts predominated significantly (p=0.01). Conclusion: the topical administration of metronidazole solution in skin wounds healing by secondary intention was able to improve the differentiation of fibroblasts. The contraction phase of wound healing remained unchanged, without significant reduction of the contraction evaluated by digital planimetry. These results can be used in favor of the wound healing process.


Subject(s)
Animals , Male , Rats , Wound Healing/drug effects , Myofibroblasts/drug effects , Metronidazole/administration & dosage , Anti-Infective Agents/administration & dosage , Administration, Topical , Rats, Wistar , Disease Models, Animal
7.
Rev. argent. cir ; 110(2): 101-105, jun. 2018. ilus, tab
Article in Spanish | LILACS | ID: biblio-957902

ABSTRACT

Antecedentes: la diverticulitis cecal es una patología poco común en los países occidentales. Clínicamente es indistinguible de una apendicitis aguda. Objetivos: exhibir los resultados de acuerdo con diferentes abordajes terapéuticos. Material y métodos: se presentan cinco casos de diverticulitis cecal tratados en nuestra institución entre enero de 2013 y diciembre de 2015. Revisión retrospectiva de historias clínicas e imágenes. Revisión de la literatura. Resultados: fueron incluidos cinco pacientes. En cuatro hubo resolución quirúrgica y uno tuvo buena evolución con tratamiento médico. Conclusiones: si bien es poco frecuente, la diverticulitis cecal debe considerarse dentro de los diagnósticos diferenciales frente a un cuadro de dolor abdominal localizado en fosa ilíaca derecha acompañado de estudios por imágenes no categóricos de apendicitis aguda.


Background: cecal diverticulitis is a rare disease in western countries. It is clinically indistinguishable from acute appendicitis. Objetive: to show outcome with different therapeutic approaches. Material and methods: we present five cases of cecal diverticulitis treated at our institution between January 2013 and December 2015. Retrospective review of medical records and images. Review of the literature. Results: five patients were included. Four cases required surgical treatment while one patient resolved with medical treatment. Conclusions: Although it is rare, cecal diverticulitis must be considered within the differential diagnoses in the face of abdominal pain located in the right iliac fossa and non-categorical imaging of acute appendicitis.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Diverticulitis/surgery , Typhlitis/pathology , Gentamicins/administration & dosage , Tomography, X-Ray Computed , Abdominal Pain/complications , Ultrasonography , Laparoscopy , Colectomy/methods , Diverticulitis/drug therapy , Diverticulitis/diagnostic imaging , Abdomen, Acute/complications , Metronidazole/administration & dosage
8.
Rev. cientif. cienc. med ; 21(1): 102-106, 2018. ilus
Article in Spanish | LILACS | ID: biblio-959744

ABSTRACT

La Apendicitis aguda continúa siendo la afección quirúrgica más frecuente en los servicios de emergencia. Se reporta el caso de masculino de 27 años, sin antecedentes de importancia, con 3 días de dolor abdominal tipo cólico, Escala Visual Análoga 8/10, fiebre, diarrea, vómitos y automedicación con analgésicos orales. Es referido de un centro privado al Hospital de Lambayeque (Perú), por hipotensión. Ingresado por shock séptico, daño renal, coagulación intravascular diseminada. Evaluado múltiples veces por cirugía, realizando laparotomía exploratoria y apendicectomía. Llevado a Unidad de Cuidados Intensivos en su postoperatorio por falla multiorgánica, shock distributivo séptico refractario a foco abdominal, síndrome de distrés respiratorio, alcalosis respiratoria con acidosis metabólica, antibioticoterapia cumplida, soporte dialítico, nutricional, doble apoyo vasopresor y conectado a ventilación mecánica. Si bien, el shock séptico refractario es una afección muy inusual secundaria a apendicitis aguda complicada como en nuestro caso, requiere estricto monitoreo para evitar complicaciones que agraven aún más el cuadro clínico.


Acute appendicitis continues to be the most frequent surgical condition in the emergency services. It's reported the case of a 27 year-old male, with no relevant history, with 3 days of colic abdominal pain, Analog Visual Scale 8/10, fever, diarrhea, vomiting, and self-medication with oral analgesics. He is referred from a private center to the Lambayeque Hospital (Peru), due to hypotension. Admitted by septic shock, kidney damage, disseminated intravascular coagulation. Evaluated multiple times by surgery, performing exploratory laparotomy and appendectomy. Carried to the ICU in its postoperative period due to multiple organ failure, distributive septic shock refractory to abdominal focus, respiratory distress syndrome, respiratory alkalosis with metabolic acidosis, fulfilled antibiotic therapy, dialytic support, nutritional, double vasopressor support and connected to mechanical ventilation. While refractory septic shock is a very unusual condition due to complicated acute appendicitis requires strict monitoring to avoid complications that aggravate even more the clinical presentation.


Subject(s)
Humans , Male , Adult , Abdominal Pain/complications , Catheterization, Central Venous , Laparotomy/methods , Metronidazole/administration & dosage
11.
Braz. J. Pharm. Sci. (Online) ; 53(1): e15218, 2017. tab, graf
Article in English | LILACS | ID: biblio-839437

ABSTRACT

Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical and in vitro studies, according to their floating ability and drug delivery. Microparticles presented mean diameter from 1.05 to 2.20 µm. The infrared spectroscopy confirmed the drug encapsulation and showed no chemical linkage between microparticles components. X-ray diffraction showed changes in the drug`s solid state, from crystalline to amorphous, indicating partial drug encapsulation, due to the presence of some crystalline peaks of metronidazole in microparticles. All microparticles floated immediately in contact of simulated gastric fluid and both floating and drug release profiles were dependent of microparticles composition. Microparticles samples constituted by chitosan and hydroxypropyl methylcellulose revealed the best relationship between floating duration and drug release, remaining floating during the occurrence of the drug release, ideal condition for the floating gastroretentive systems.


Subject(s)
Solid Waste Grinding , Drug Liberation , Metronidazole/administration & dosage , Chitosan/pharmacokinetics , Hypromellose Derivatives
12.
Porto Alegre; Universidade Federal do Rio Grande do Sul. Telessaúde; 2017. ilus.
Non-conventional in Portuguese | LILACS | ID: biblio-995634

ABSTRACT

A Lesão por Pressão (LP) é um dano localizado na pele e/ou tecidos moles subjacentes, geralmente sobre uma proeminência óssea, relacionada ao uso de dispositivo médico ou a outro artefato. É um problema de saúde frequente no atendimento da Atenção Primária à Saúde (APS), especialmente identificado em visitas domiciliares na avaliação de pacientes acamados, podendo levar a repercussões graves como infecção bacteriana disseminada e osteomielite. Esta guia apresenta informação que orienta a conduta para casos de lesão por pressão no contexto da Atenção Primária à Saúde, incluindo: etiologia, classificação, características da lesão conforme estágio, tipos de tecido, avaliação e tratamento da infecção, check-list, cuidados com a ferida, escolha da cobertura, irrigação da lesão, desbridamento, controle do odor, medidas preventivas.


Subject(s)
Humans , Wounds and Injuries/nursing , Pressure Ulcer/diagnosis , Pressure Ulcer/therapy , Primary Health Care , Debridement/instrumentation , Metronidazole/administration & dosage
13.
Rev. Col. Bras. Cir ; 42(5): 352-355, Sept.-Oct. 2015. graf
Article in Portuguese | LILACS | ID: lil-767850

ABSTRACT

The authors present an evidence-based case report of a patient with agenesis or pseudoagenesis of the dorsal pancreas.


Os autores apresentam um relato de caso baseado em evidência de uma paciente com agenesia ou pseudoagenesia de pâncreas dorsal.


Subject(s)
Humans , Amoxicillin/administration & dosage , Anti-Bacterial Agents/administration & dosage , Metronidazole/administration & dosage , Periodontitis/drug therapy , Wound Healing/drug effects , Dental Scaling/methods , Randomized Controlled Trials as Topic , Reproducibility of Results , Treatment Outcome
14.
J. appl. oral sci ; 23(3): 249-254, May-Jun/2015. graf
Article in English | LILACS, BBO | ID: lil-752430

ABSTRACT

Objective The aim of this systematic review was to compare the clinical effectiveness of systemic antibiotics administered in the active stage of periodontal treatment or after the healing phase. Material and Methods An electronic search was performed in the databases EMBASE, MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL), in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. A manual search of the reference list of selected studies and of review articles was also performed up to November 2013. Randomized Clinical Trials (RCT) that evaluated the systemic administration of antibiotics as adjuvants to scaling and root planning (SRP) at different phases of periodontal treatment were included. Systematic reviews and studies that evaluated subjects with systemic diseases and those that used subantimicrobial doses of antibiotics were excluded. Results The initial search identified 1,039 articles, of which seven were selected, and only one met the inclusion criteria. This study showed that subjects taking metronidazole and amoxicillin at the initial phase of treatment exhibited statistically significantly greater reduction in pocket depth and gain in clinical attachment level in initially deep sites (PD≥7 mm) than subjects taking antibiotics after healing (p<0.05). This comparison was conducted 2 months after antibiotic intake, at the healing phase. Conclusion To date, only one short-term RCT has directly compared different moments of systemic antibiotics administration, as adjuncts to SRP, in the treatment of periodontitis. Although the results of this study suggested some benefits for antibiotics intake during the active phase of therapy, these findings need to be confirmed by larger placebo-controlled randomized clinical trials with longer follow-up periods. .


Subject(s)
Humans , Amoxicillin/administration & dosage , Anti-Bacterial Agents/administration & dosage , Metronidazole/administration & dosage , Periodontitis/drug therapy , Wound Healing/drug effects , Dental Scaling/methods , Randomized Controlled Trials as Topic , Reproducibility of Results , Treatment Outcome
15.
Rev. chil. infectol ; 32(2): 135-141, abr. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-747515

ABSTRACT

Introduction: Metronidazole is the antibiotic of choice for the management of infections caused by anaerobes. Its administration requires multiple daily doses causing increased medication errors. Due to its high post-antibiotic effect and rapid concentration-dependent bactericidal activity, administration of this antibiotic in an extended dosing interval would achieve PK/PD parameters effectively. Objective: To assess the probability of achieving effective PK/PD relationship with the administration of 1,000 mg every 24 hours of metronidazole for Bacteroides fragilis infections. Methods: A clinical trial was conducted in a group of volunteers who received a single oral dose of 500 or 1,000 mg of metronidazole. Determinations of values of Cmax, t max, and AUCC0-24 h. determined using the trapezoidal method, were obtained for a Markov simulation that would allow for determining the likelihood of achieving a AUC0-24 h/MIC ratio above 70 for infections caused by susceptible B. fragilis. Results: Cmax (24,03 ± 6,89 mg/L) and t max (1,20 ± 0.80 hrs) and the value of AUC0-24 h (241.91 ± 48.14 mg * h/L) were determined. The probability of obtaining a AUC0-24 h/MIC ratio greater than 70 was greater than 99%. Conclusion: From a pharmacokinetic perspective, with the administration of a daily dose of 1,000 mg of metronidazole, it is possible to achieve a therapeutic goal of AUC0-24 h/MIC ratio above 70 for the treatment of anaerobic infections.


Introducción: Metronidazol es el antimicrobiano de elección para el manejo de infecciones anaeróbicas. Su administración requiere de dosis múltiples provocando aumento en errores medicamentosos. Debido al efecto post-antibiótico y a la actividad bactericida concentración-dependiente, la administración de metronidazol en intervalos ampliados de administración permitiría alcanzar parámetros PK/PD efectivos. Objetivo: Evaluar la probabilidad de alcanzar una relación PK/PD efectiva con la administración de 1.000 mg cada 24 h de metronidazol para infecciones por Bacteroides fragilis. Método: Se realizó un ensayo clínico sobre un grupo de voluntarios a quienes se les administró una monodosis oral de 500 y 1.000 mg de metronidazol, respectivamente. Se establecieron parámetros farmacocinéticos empleando el método trapezoidal. Se realizó una simulación de Markov que permitiera establecer la probabilidad de alcanzar una relación AUC0-24 h/CIM > 70 en infecciones por B. fragilis. Resultados: Se determinaron los valores de Cmax (24,03 ± 6,89 mg/L), t max (1,20± 0,8h) y AUC0-24 h (241,91 ± 48,14 mg*h/L), con lo cual la probabilidad de alcanzar una relación AUC0-24 h/CIM > 70 con 1.000 mg de metronidazol fue superior a 99%. Conclusión: Con la administración de 1.000 mg cada 24 h sería posible alcanzar una relación PK/PD efectiva para el tratamiento de infecciones anaeróbicas.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Anti-Bacterial Agents/pharmacokinetics , Bacteroides Infections/drug therapy , Bacteroides Infections/metabolism , Bacteroides fragilis , Metronidazole/pharmacokinetics , Administration, Oral , Anti-Bacterial Agents/administration & dosage , Drug Administration Schedule , Markov Chains , Metronidazole/administration & dosage
16.
Gut and Liver ; : 478-485, 2015.
Article in English | WPRIM | ID: wpr-149102

ABSTRACT

BACKGROUND/AIMS: Bismuth-containing quadruple and moxifloxacin-based triple regimens are recommended as second-line therapy for Helicobacter pylori infection. The aim of this study was to compare the efficacy of each regimen. METHODS: From August 2004 to October 2012, a total of 949 patients (mean age, 54.32+/-12.08 years; male, 49.4%) who failed H. pylori eradication with a standard triple regimen were included. Patients treated with a bismuth-containing quadruple regimen for 7 and 14 days were designated as 7-BMT and 14-BMT, respectively, and those treated with a moxifloxacin-based triple regimen for 7 and 14 days were designated as 7-MA and 14-MA, respectively. H. pylori eradication was confirmed using the 13C-urea breath test, rapid urease test or histology. RESULTS: The eradication rates by 7-BMT, 14-BMT, 7-MA, and 14-MA were 66.4% (290/437), 71.1% (113/159), 53.1% (51/96), and 73.5% (189/257), respectively, by intention-to-treat analysis (ITT) and 76.5% (284/371), 83.8% (109/130), 55.6% (50/90), and 80.6% (187/232), respectively, by per-protocol analysis (PP). The eradication rates were higher in 14-BMT than 7-BMT by the ITT and PP analyses (p=0.277 and p=0.082, respectively). The 14-BMT and 14-MA treatments showed similar efficacies by ITT and PP (p=0.583 and p=0.443, respectively). CONCLUSIONS: The 7-BMT, 14-BMT, and 14-MA treatments showed similar and suboptimal efficacies. In both regimens, extending the duration of treatment may be reasonable considering the high level of antibiotic resistance in Korea.


Subject(s)
Adult , Aged , Amoxicillin/administration & dosage , Antacids/administration & dosage , Anti-Infective Agents/administration & dosage , Bismuth/administration & dosage , Drug Administration Schedule , Drug Therapy, Combination/methods , Female , Fluoroquinolones/administration & dosage , Helicobacter Infections/drug therapy , Helicobacter pylori , Humans , Intention to Treat Analysis , Male , Metronidazole/administration & dosage , Middle Aged , Proton Pump Inhibitors/administration & dosage , Retrospective Studies , Tetracycline/administration & dosage , Treatment Outcome
18.
Säo Paulo med. j ; 132(2): 121-124, 2014. tab, graf
Article in English | LILACS | ID: lil-705383

ABSTRACT

CONTEXT: Solitary brainstem abscesses are rare and they are usually associated with other infections. They are severe conditions with high morbidity and mortality. The surgical options are stereotactic aspiration and microsurgical drainage. Systemic antibiotic therapy is used for more than six weeks. CASE REPORT: We present the case of a young man with a solitary abscess at the pons, without other systemic infections. The patient was treated by means of microsurgical drainage and antibiotic therapy for three weeks. His postoperative recovery was good. CONCLUSIONS: A microsurgical approach may be considered to be an important option for large abscesses that are multiloculated, close to the surface or contain thick fluid. Complete emptying of the purulent accumulation may diminish the required duration of antibiotic therapy. .


CONTEXTO: Abscessos isolados do tronco encefálico são raros e geralmente associados a outras infecções. Trata-se de condição grave, com grande morbidade e mortalidade. Opções cirúrgicas são aspiração com estereotaxia e drenagem microcirúrgica. Antibioticoterapia sistêmica tem sido usada por mais de seis semanas. RELATO DE CASO: Apresentamos o caso de um jovem com abscesso pontino sem outras infecções sistêmicas. O paciente foi tratado com drenagem microcirúrgica e antibioticoterapia por três semanas. Houve boa evolução pós-operatória. CONCLUSÕES: Acesso microcirúrgico pode ser considerado uma opção importante no tratamento de grandes abscessos do tronco encefálico, que são multiloculados, próximos da superfície ou que contenham líquido espesso. Drenagem completa do material purulento pode diminuir o período de antibioticoterapia. .


Subject(s)
Adult , Humans , Male , Anti-Bacterial Agents/administration & dosage , Brain Abscess/drug therapy , Brain Abscess/surgery , Brain Stem/surgery , Microsurgery/methods , Ceftriaxone/administration & dosage , Magnetic Resonance Imaging , Metronidazole/administration & dosage , Oxacillin/administration & dosage , Suction/methods , Time Factors
19.
Braz. dent. j ; 24(1): 68-73, 2013. tab, graf
Article in English | LILACS | ID: lil-671356

ABSTRACT

Dental materials with antibacterial properties can prevent the harmful effects caused by oral cariogenic bacteria. This double-blind controlled clinical trial evaluated the performance of a glass ionomer cement (GIC) added with antibiotics for sealing infected dentin in atraumatic restorations of primary molars. The study enrolled 45 children (45 teeth) between 5 and 8 years of age, of both genders, divided into two groups: GC (n=22), where cavities were lined with a conventional GIC (Vidrion F) and GA (n=23), with cavities lined with Vidrion F added with 1% each of metronidazole, ciprofloxacin and cefaclor antibiotic. Both groups were restored with Ketac Molar Easymix. Molars with carious lesions on the inner half of dentin without clinical or radiographic pulp damage were selected. Patients were evaluated clinically (pain, fistulas or mobility) and radiographically (area of caries, periapical region and furcation) after 1, 3, 6 and 12 months. For statistical analysis, chi-squared or Fisher's exact tests were used with a 5% significance level. GA (82.6-95.7%) had better results than GC (12.5-36.4%) in all evaluations (p<0.05) and the difference in the success rate was 46.2-72.5% higher for GA. The use of the antibiotic-containing GIC liner on infected dentin proved satisfactory when applied in deciduous teeth.


Os materiais dentários com propriedades antibacterianas podem proteger os efeitos nocivos causados por bactérias cariogênicas. Este ensaio clínico controlado duplo-cego avaliou o desempenho do cimento de ionômero de vidro (CIV) associado à antibióticos no selamento da dentina infectada em restaurações atraumáticas de molares decíduos. O estudo envolveu 45 crianças (45 dentes) entre 5 e 8 anos de idade, de ambos os sexos, divididos em dois grupos: GC (n=22), onde as cavidades foram forradas com CIV convencional (Vidrion F) e GA (n=23), onde as cavidades foram forradas com Vidrion F contendo 1% de cada um dos antibióticos metronidazole, ciprofloxacina e cefaclor. Ambos os grupos foram restaurados com Ketac Molar Easymix. Molares com lesões de cárie na metade interna da dentina, sem danos pulpares clínicos ou radiográficos foram selecionados. Os pacientes foram avaliados clinicamente (presença de dor, fístulas ou mobilidade) e radiograficamente (área de cárie, região periapical e de furca dos dentes), após 1, 3, 6 e 12 meses. Para a análise estatística o Qui-quadrado ou Exato de Fisher foram utilizados com 5,0% de significância. GA (82,6-95,7%) obteve melhores resultados do que GC (12,5-36,4%) em todas as avaliações (p<0,05) e a diferença na taxa de sucesso foi de 46,2-72,5% maior para GA. O uso do CIV com antibióticos no forramento da dentina infectada foi satisfatório em dentes decíduos.


Subject(s)
Child , Child, Preschool , Female , Humans , Male , Anti-Bacterial Agents/administration & dosage , Cariostatic Agents/chemistry , Dental Cavity Lining , Dental Atraumatic Restorative Treatment/methods , Dental Caries/therapy , Dentin/pathology , Glass Ionomer Cements/therapeutic use , Chi-Square Distribution , Cariostatic Agents/therapeutic use , Cefaclor/administration & dosage , Ciprofloxacin/administration & dosage , Double-Blind Method , Dentin/microbiology , Glass Ionomer Cements/chemistry , Metronidazole/administration & dosage , Tooth, Deciduous
20.
Porto Alegre; s.n; 2012. 81 p. ilus, tab, graf.
Thesis in Portuguese | LILACS, BBO | ID: biblio-865986

ABSTRACT

Objetivo: avaliar o possível efeito da obesidade sobre o tratamento periodontal não-cirúrgico associado ou não a antibiótico em mulheres de peso normal e obesas após 6 meses de acompanhamento. Metodologia: a partir de um delineamento do tipo ensaio clínico randomizado, controlado por placebo, em paralelo, 32 mulheres (35-55 anos) com periodontite crônica foram incluídas e distribuídas em dois grupo experimentais (16 peso normal e 16 obesas). Mulheres fumantes, diabéticas e com sobrepeso não foram incluídas. As pacientes foram alocadas randomicamente para receber tratamento periodontal subgengival associado ao uso de placebo ou metronidazol (400mg, 3x/dia, durante 10 dias) concomitantemente. Os parâmetros clínicos periodontais foram avaliados por um examinador treinado e calibrado no baseline e 6 meses após o tratamento periodontal. Resultados: Todos os parâmetros clínicos apresentaram melhora durante o período de acompanhamento. O Índice de Placa Visível foi positivo em aproximadamente 25% dos sítios nos grupos experimentais após 6 meses do tratamento, enquanto que o Índice de Sangramento Gengival e o Sangramento à Sondagem foram observados em aproximadamente 10% e 25% dos sítios, respectivamente. Esses parâmetros não apresentaram diferenças significativas entre os grupos experimentais aos 6 meses. A redução na Profundidade de Sondagem variou entre 0.52 ± 0.3 e 0.81 ± 0.5mm e o ganho de Inserção Clínica variou entre 0.23 ± 0.3 e 0.45 ± 0.5mm. Não foram observadas diferenças estatisticamente significativas entre os grupos experimentais para estes parâmetros (P=0.59 e 0.67, respectivamente). Conclusão: Ponderando as limitações desta análise preliminar, obesidade parece não afetar negativamente os resultados da terapia periodontal não-cirúrgica. Além disso, o uso de Metronidazol não forneceu um benefício adicional a terapia periodontal.


Aim: to evaluate the possible effects of obesity on clinical parameters after systemic antibiotic adjunctive scaling and root planning (SRP) in women with 6 month follow-up. Methods: a randomized clinical trial was conducted. Thirty-two women (35 - 55 years old) with chronic periodontitis were allocated into obesity (n=16) and normal weight (n=16) groups. Smokers, diabetics and overweight were not included. Patients were randomized to SRP plus Metronidazole (400 mg, 3 time/day, 10 days) or SRP plus placebo. Periodontal parameters were evaluated by one calibrated examiner at baseline and 6 month follow-up. Results: all periodontal parameters showed improvement during follow-up. Visible Plaque Index was positive around 25% of sites in the experimental groups after 6 months of treatment, while the Gingival Bleeding Index and Bleeding on Probing were observed in approximately 10% and 25% of the sites, respectively. These parameters showed no significant differences between experimental groups at 6 months. Probing Pocket Depth was reduced ranged 0.52 ± 0.3 and 0.81 ± 0.5 mm and Periodontal attachment loss get ranged 0.23 ± 0.3 and 0.45 ± 0.5 mm. There were no statistically significant differences between experimental groups for these parameters (P=0.59 and 0.67, respectively). Conclusion: Considering the limitations of this preliminary analysis, obesity seems not affect the results of nonsurgical periodontal therapy. Furthermore, the use of Metronidazole was not provided an additional benefit to periodontal therapy.


Subject(s)
Humans , Female , Adult , Middle Aged , Metronidazole/administration & dosage , Obesity/complications , Periodontitis/therapy , Surveys and Questionnaires
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