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1.
Rev. Ciênc. Plur ; 8(1): e24820, 2022. tab, graf
Article in Portuguese | LILACS, BBO | ID: biblio-1348511

ABSTRACT

Introdução:O carcinoma de células escamosas de cavidade oral e orofaringe é uma neoplasia epitelial maligna comum, respondendo pela maioria dos casos de tumores de cabeça e pescoço. Ele está relacionado a hábitos comportamentais, como tabagismo e etilismo de longa duração, e à infecção pelo Papilomavírus humano. Objetivos:Esse estudo objetivou descrever o perfil epidemiológico dos pacientes diagnosticados com essa neoplasia na Liga Mossoroense de Estudos e Combate ao Câncer. Metodologia: Foi realizado um estudo observacional com delineamento transversal a partir de dados presentes nos prontuários clínicos e laudos anatomopatológicos e no Sistema de Informações sobre Mortalidade no período entre 2006 a 2018. Os dados foram analisados a partir do Software R, utilizandoo teste de Wilcoxon-Mann-Whitney para as análises inferenciais e o método de Kaplan-Meier para análise da sobrevida. Resultados:225 prontuários foram analisados, sendo 70,22% de homens, 65,33% na faixa etária entre 46-70 anos e cor branca (51,57%). Destes, 25,78% eram tabagistas e 39,11% tabagistas e etilistas. O principal tratamento identificado foi a associação de cirurgia, quimioterapia e radioterapia. Observou-se que 49,10% dos óbitos foram em decorrência dessa neoplasia. O principal estádio patológico encontrado foi o quatro A (34,22%). Foi identificada maior sobrevida nos pacientes acima de 70 anos, cujo tratamento foi exclusivamente cirúrgico. Menor sobrevida foi identificada em indivíduos que tinham associação de hábitos (etilismo e tabagismo). Conclusões:Nossos resultados sugerem que a evolução à óbito foi o principal desfecho clínico e, isso pode estar relacionado aos hábitos comportamentais que influenciam diretamente o curso e prognóstico da doença. Ademais, destaca-se a importância do diagnóstico precoce a fim de reduzir óbitos e melhorar a qualidade de vida dos indivíduos, assim como a necessidade de implementar políticas educativas sobre os principais fatores de risco associados ao desenvolvimento dessa neoplasia (AU).


Introduction: Squamous cell carcinoma of the oral cavity and oropharynx is a common malignant epithelial neoplasm, accounting for most cases of head and neck tumors. It is related to behavioral habits, such as long-standing smoking and alcoholism, as well as to the human Papillomavirus infection. Objectives: This study aimed at describing the epidemiological profile of the patients diagnosed with this neoplasm in the Mossoró League for Studying and Combating Cancer. Methodology:An observational study with a cross-sectional design was carried out based on data present in the medical records and anatomopathological reports and in the Mortality Information System during the 2006-2018 period. The data were analyzed using the R Software, resorting to the Wilcoxon-Mann-Whitneytest for the inferential analyses and to the Kaplan-Meier method for survival analysis. Results: 225 medical records were analyzed: 70.22% belonging to men, 65.33% aged between 46 and 70 years old and white-skinned (51.57%). Of these, 25.78% were smokers and 39.11% were smokers and alcoholics. The main treatment identified was the association of surgery, chemotherapy and radiotherapy. It was observed that 49.10% of the deaths were due to this neoplasm. The main pathological stage found wasfour A(34.22%).Longer survival was identified in patients over 70 years of age, whose treatment was exclusively surgical. Shorter survival was identified in individuals who had associated habits (alcoholism and smoking). Conclusions:Our results suggest that evolution to death was the main clinical outcome; this can be related to the behavioral habits that exert a direct influence on the course and prognosis of the disease. Furthermore, the importance of early diagnosis is highlighted in order to reduce the number of deaths and improve the individuals' quality of life, as well as the need to implement educational policies on the main risk factors associated with the development of this neoplasm (AU).


Introducción: El carcinoma de células escamosas de la cavidad oral y la orofaringe es una neoplasia epitelial maligna común, que representa la mayoría de los casos de tumores de cabeza y cuello. Se relaciona con hábitos de comportamiento, como el tabaquismo y el alcoholismo, y la infección por el virus papiloma humano. Objetivos:Este estudio tuvo como objetivo describir el perfil epidemiológico de los pacientes diagnosticados con esta neoplasiaen la Liga Mossoroense de Estudios y Combate al Cáncer. Metodología: Se realizó un estudio observacional, transversal a partir de los datos presentes en las historias clínicas e informes patológicos y en el Sistema de Información de Mortalidad en el período 2006-2018. Los datos se analizaron mediante el Software R, con utilización de la Prueba de Wilcoxon-Mann-Whitney para análisis inferencial y el método de Kaplan-Meier para análisis de supervivencia. Resultados:Se analizaron 225 historias clínicas, 70,22% en hombres, 65,33% con edades entre 46-70 años y blancos (51,57%). De estos, 25,78% eran fumadores y 39,11% eran fumadores y alcohólicos. El principal tratamiento identificado fue la asociación de cirugía, quimioterapia y radioterapia. 49,10% de las muertes se debieron a esta neoplasia. El principal estadio patológico encontrado fue cuatro A (34,22%). Se identificó mayor sobrevida en pacientes mayores de 70 años, cuyo tratamiento fue exclusivamente quirúrgico. Se identificó una menor sobrevida en personas que tenían hábitos asociados. Conclusiones:Nuestros resultados sugieren que la evolución hacia la muerte fue el principal resultado clínico y esto puede estar relacionado con hábitos de comportamiento que influyen directamente en el curso y pronóstico de la enfermedad. Además, se destaca la importancia del diagnóstico precoz para reducir las muertes y mejorar la calidad de vida, así como la necesidad de implementar políticas educativas sobre los principales factores de riesgo asociados al desarrollo de esta neoplasia (AU).


Subject(s)
Humans , Health Profile , Brazil/epidemiology , Mouth Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Oropharyngeal Neoplasms/pathology , Head and Neck Neoplasms/pathology , Tobacco Use Disorder , Survival Analysis , Epidemiology , Cross-Sectional Studies , Statistics, Nonparametric , Papillomavirus Infections , Research Report , Smokers
2.
Rev. Ciênc. Plur ; 8(1): e24554, 2022. tab
Article in Portuguese | LILACS, BBO | ID: biblio-1348513

ABSTRACT

Introdução:O câncer de cabeça e pescoço é um conjunto de neoplasias que atingem o trato aero digestivo superior. Essas neoplasias apresentam sintomatologia variada, que depende da localização do tumor, gravidade e tempo de ocorrência. Objetivo:Avaliar o nível de conhecimento da população, usuária da atenção básica, acerca da prevenção e tratamento dos Cânceres de Cabeça e Pescoço.Metodologia:Trata-se de um estudo de campo transversal descritivo, em que se coletou informações acerca do conhecimento sobre cânceres de cabeça e pescoço, informações sociodemográficas, histórico familiar, características clínicas e de tratamentos. A coleta foi realizada em julho de 2019, em três Estratégias de Saúde da Família da cidade de Piripiri,Piauí. A pesquisa foi submetida e aprovadapelo Comitê de Ética em Pesquisa com o Parecer nº 3.221.522.Resultadose discussão:A maioria dos entrevistados foram mulheres solteiras com idade média de 44,4 anos e de baixa renda. Dentre os questionamentos realizados, grande parte não soube responderquestões sobre conhecimentos gerais a respeito dessas enfermidades. Outro fator importante é a baixa procura por serviços de saúde. Conclusões:Observou-se que os entrevistados apresentam desinformação a respeito da prevenção e tratamento desse grupo de cânceres, sendo necessário o fortalecimento de ações de educação popular em saúde (AU).


Introduction:Head and neck cancer is a group of neoplasms that affect the upper aerodigestive tract. These neoplasms have varied symptoms, depending on the location of the tumor, severity and time of occurrence.Objective:To assess the level of knowledge of the population, users of primary care, about the prevention and treatment of Head and Neck Cancer. Methodology:This is a descriptive cross-sectional study, in which information about knowledge about head and neck cancers, sociodemographic information, family history, clinical and treatment characteristics was collected. The collection was carried out in July 2019, in three Family Health Strategies in the city of Piripiri, Piauí. The research was submitted and approved by theResearch Ethics Committee with Opinion No. 3,221,522. Resultsand discussion:Most of the interviewees were single women with an average age of 44.4 years and low income. Among the questions asked, most of them did not know how to answer questions about general knowledge about these diseases. Another important factor is the low demand for health services. Conclusions:It was observed that the interviewees have misinformation regarding the prevention and treatment of this group of cancers, and it is necessary to strengthen popular health education actions (AU).


Introducción:El cáncer de cabeza y cuello es un grupo de neoplasias que afectan el tracto aerodigestivo superior. Estas neoplasias tienen síntomas variados, que dependen de la ubicación del tumor, la gravedad y el momento de aparición. Objetivo:Evaluar el nivel de conocimiento de la población, usuarios de la atención primaria de salud, sobre la prevención y el tratamiento del Cáncer de Cabeza y Cuello. Metodología:Se trata de un estudio descriptivo transversal, en el que se recopiló información sobre conocimientos sobre cánceres de cabeza y cuello, información sociodemográfica, antecedentes familiares, características clínicas y de tratamiento. La recolección se realizó en julio de 2019, en tres Estrategias de Salud de la Familia en la ciudad de Piripiri, Piauí. La investigación fue sometida y aprobada por el Comité de Ética en Investigación con Opinión No. 3.221.522. Resultados y discusión:La mayoría de los encuestados eran mujeres solteras con una edad promedio de 44,4 años y bajos ingresos. Entre las preguntas formuladas, la mayoría de ellos no sabía cómo responder preguntas sobre conocimientos generales sobre estas enfermedades. Otro factor importante es la baja demanda de servicios de salud. Conclusiones:Se observó que los entrevistados tienen desinformación sobre la prevención y tratamiento de este grupo de cánceres, y es necesario fortalecer las acciones de educación popular en salud (AU).


Subject(s)
Humans , Male , Female , Adolescent , Adult , Primary Health Care , Primary Prevention , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Head and Neck Neoplasms/pathology , Brazil/epidemiology , Health Education , Epidemiology, Descriptive , Cross-Sectional Studies/methods , Surveys and Questionnaires , Disease Prevention
3.
Braz. j. oral sci ; 20: e219638, jan.-dez. 2021. tab
Article in English | LILACS, BBO | ID: biblio-1254752

ABSTRACT

Diagnosis of oral and oropharyngeal cancer in advanced stages may be associated with social nature factors, access to health care, education, occupation, and behavioral/ cultural factors. Aim: To determine the factors related to high clinical-staging in patients diagnosed with squamous cell carcinoma in the oral and oropharyngeal region in a Cancer Center in Brazil between 2009 and 2015. Methods: It is an epidemiological, retrospective, and exploratory study. Patients diagnosed with squamous cell carcinoma had their medical records analyzed. The variables considered were sociodemographic, lifestyle, and disease characteristics. Descriptive and exploratory tests (Pearson's, chi-square test and, Student's t-test) were realized. Results: We analyzed 365 patient records, among which 289 (79.17%) were male, and 73 (20.0%) were female. Age ranged from 16 to 101 years, with a mean of 61.13. Regarding education, 157 (43.01%) studied < 8 years, 103 (28.21%) were illiterate and 102 (27.94%) studied > 8 years. 305 (83.56%) patients live in urban areas. There was an association between high clinical-staging and low educational level. For high clinical-staging, symptomatology, tobacco, and alcohol intake as well. Conclusion: Patients with low educational levels tend to report the disease later, and their diagnostics occurred in advanced stages. Thus, specific public health policies for this population, including access to dental care to recognize the clinical signs and early diagnosis, are necessary


Subject(s)
Socioeconomic Factors , Mouth Neoplasms/diagnosis , Oropharyngeal Neoplasms/diagnosis , Medical Records
4.
Prensa méd. argent ; 107(8): 406-411, 20210000. fig
Article in Spanish | LILACS, BINACIS | ID: biblio-1358658

ABSTRACT

Objetivo: Los pacientes con enfermedad por el virus de la inmunodeficiencia humana suelen presentar lesiones orales, hasta en un 50% de los casos con diagnóstico de sida. La displasia fibrosa es una lesión intra-ósea caracterizada por una alteración del crecimiento y diferenciación de los osteoblastos debida a una mutación genética. Clínicamente se caracteriza por presentar una tumoración de lento crecimiento con dolor, deformidad ósea y, en ocasiones, fracturas ante traumas mínimos. Caso clínico: Se presenta una paciente con sida y tuberculosis diseminada que desarrolló una lesión ósea tumoral , con compromiso de paladar y encía superior derecha, cuyo diagnóstico histopatológico fue de displasia fibrosa de paladar óseo y maxilar superior. Conclusión: La displasia fibrosa debe incluirse en el diagnóstico diferencial de las lesiones tumorales orales de los pacientes con enfermedad VIH/sida.


Aim: Patients with human immunodeficiency virus infection usually have oral lesions, including up to 50% of patients diagnosed with AIDS. Fibrous dysplasia is an intra-bone lesion, characterized by an alteration of the growth and differentiation of osteoblastes produced by a genetic mutation. Clinically it is characterized by presenting a tumor of slow growth with pain, bone deformity and sometimes fractures to minimal trauma. Clinical case: Here we describe a patient with AIDS and disseminated tuberculosis who developed a large tumor lesion that involve the hard palate and the maxilla. Final histopathological diagnosis was of fibrous dysplasia involving the hard palate and the upper maxilla. Conclusion: fibrous dysplasia should be included in the differential diagnosis of intraoral tumor lesions in HIV/AIDS patients.


Subject(s)
Humans , Female , Adult , Mouth Neoplasms/etiology , Mouth Neoplasms/therapy , HIV Infections/therapy , Early Diagnosis , Diagnosis, Differential , Fibrous Dysplasia, Monostotic/therapy
5.
Rev. cuba. estomatol ; 58(3): e3604, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347432

ABSTRACT

Introducción: Debido al aumento en la esperanza de vida y, en consecuencia, al aumento en el número de personas mayores, la asociación entre los estados de salud se vuelve relevante en términos de salud pública, ya que además de los años vividos, la calidad de vida de estos pacientes es importante. Objetivo: Evaluar la autopercepción y el estado de salud bucal en personas mayores. Métodos: Estudio observacional, de corte transversal (enero-julio del 2019) en el que se realizaron cuestionarios GOHAI (índice de evaluación de la salud oral geriátrica) y el cuestionario sobre el tipo, el tiempo de uso y la limpieza de las prótesis dentales, el cáncer oral y los datos socioeconómicos. La presencia de posibles lesiones orales también se evaluó mediante examen clínico. Los sujetos incluidos en la muestra eran ancianos (60 años o más) que asistían a las unidades de salud de Aracaju. Resultados: Participaron 55 mujeres y ocho hombres. Al evaluar el índice de evaluación de la salud oral geriátrica, se verificó que el 47,6 por ciento de la muestra tenía una mala percepción de la salud oral. Se encontraron asociaciones entre el índice de evaluación de la salud oral geriátrica entre la última visita al dentista, la adaptación de la prótesis dental y las heridas bucales (p < 0,05). Las lesiones orales más prevalentes fueron mucosa rojiza o irritada (35,7 por ciento) y eritroplasia (14,2 por ciento) y se detectó que el 76 por ciento de las prótesis tenían grietas o suciedad. El 77,7 por ciento de los participantes en el estudio solo utilizaban dentífrico como material de limpieza de la prótesis. Conclusión: La salud bucal autopercibida y las condiciones de salud bucal de los ancianos evaluados se consideraron deficientes, se observa la presencia de prótesis mal adaptadas y agrietadas, además de mucositis(AU)


Introduction: due to the increase in life expectancy and, consequently, to the increase in the number of elderly people, the association between health states becomes relevant in terms of public health, since in addition to the lived years the quality of life of these patients is important. Objective: evaluate the self-perception of oral health and check the oral health condition of the elderly. Methods: observational cross-sectional study (January to July / 2019) in which questionnaires were the GOHAI (Geriatric Oral Health Assessment Index) questionnaire and questionnaire about type, time of use and cleaning of dental prostheses, oral cancer and socioeconomic data. The presence of possible oral lesions was also assessed by clinical examination. The subjects included in the sample were elderly (60 years or older) attending the Aracaju Health Units. Results: fifty-five were female and eight male. When evaluating the Geriatric Oral Health Assessment Index, it is verified that 47.6 percent of the sample has poor self-perception of oral health. Associations were found between GOHAI Index for last visit to the dentist, dental prosthesis adaptation and mouth wound (p < 0.05). The most prevalent oral lesions were reddish or irritated mucosa (35.7 percent), followed by erythroplakia (14.2 percent), 76 percent of the prostheses had cracks or dirt. About the cleaning of the protests, 77.7 percent use only dentifrice as cleaning material. Conclusion: self-perceived oral health and oral health conditions of the elderly evaluated were considered poor, in the presence of poorly adapted and cracked prostheses, in addition to mucositis(AU)


Subject(s)
Humans , Aged , Aged, 80 and over , Self Concept , Mouth Neoplasms/epidemiology , Life Expectancy , Dental Care for Aged/adverse effects , Dental Prosthesis/methods , Quality of Life , Cross-Sectional Studies , Surveys and Questionnaires , Observational Studies as Topic
6.
Rev. Asoc. Odontol. Argent ; 109(2): 100-106, ago. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1348405

ABSTRACT

Objetivo: Presentar un caso clínico de Linfoma de Burkitt esporádico en cavidad bucal como manifestación inicial en un paciente adulto joven, tratado en el Hospital Interzonal General de Agudos "General José de San Martín" de La Plata. Caso clínico: Un paciente masculino de 20 años de edad se presenta con una lesión tumoral localizada en sector posterior de reborde mandibular, pérdida espontánea de piezas dentarias y parestesia del nervio dentario inferior. Acompañado de un aumento de volumen testicular, compromiso intestinal y poliadenopatías. El cuadro morfológico y de inmuno-marcación confirma un Linfoma de Células B "agresivo". El paciente fue tratado con esquema intensivo de 6 bloques de quimioterapia y terapia intratecal. No se observaron señales de recurrencia durante el período de seguimiento de 12 meses. Las manifestaciones bucales iniciales del Linfoma de Burkitt deben considerarse en el diagnóstico diferencial de las enfermedades bucales benignas. Debido a su naturaleza agresiva, el reconocimiento temprano y rápido de este linfoma es esencial para la administración oportuna de la terapia adecuada y mejora el pronóstico del paciente (AU)


Aim: To present a case of sporadic Burkitt's lymphoma with oral initial manifestatios in a young adult patient, who received treatment at the Hospital Interzonal General de Agudos "General José de San Martín", La Plata. Clinical case: A 20-year-old male patient presents with a tumor lesion located in the posterior area of the mandibular ridge, spontaneous loss of teeth and paresthesia of the inferior dental nerve, increase in testicular volume, intestinal compromise and polyadenopathy. The morphological and immunostaining conditions confirm an "aggressive" B-Cell Lymphoma. The patient received an intensive scheme of 6 blocks of chemotherapy and intrathecal therapy. No signs of recurrence were observed during the 12-month follow-up period. Oral manifestations of Burkitt´s lymphoma in the initial stages should be considered in the differential diagnosis of benign oral diseases. Due to its aggressive nature, early and rapid recognition of these this lymphoma is essential for the timely administration of adequate therapy and for a patient's better prognosis (AU)


Subject(s)
Humans , Male , Adult , Mouth Neoplasms , Burkitt Lymphoma , Argentina , Prognosis , Recurrence , Signs and Symptoms , Lymphoma, B-Cell , Dental Service, Hospital , Early Diagnosis , Diagnosis, Differential , Drug Therapy
7.
Rev. Soc. Odontol. La Plata ; 31(60): 23-26, jul. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1284468

ABSTRACT

Las neoplasias malignas de la cavidad oral en gran medida (90%) consisten en carcinoma de células escamosas que surgen de la mucosa de revestimiento. El 10% restantes de neoplasias malignas orales de un grupo heterogéneo de tumores de diferente etiología. Presentamos dos casos de patología oncohematológica: Mieloma Múltiple (AU)


Malignant neoplasms of the oral cavity largely (90%) consist of squamous cell carcinoma arising from the lining mucosa. e remaining 10% of oral malignancies from a heterogeneous group of tumors of different etiology. We present two cases of oncohematological pathology: Multiple Myeloma (AU)


Subject(s)
Humans , Male , Middle Aged , Plasmacytoma/diagnosis , Plasmacytoma/pathology , Plasmacytoma/diagnostic imaging , Mouth Neoplasms/diagnosis , Radiotherapy , Biopsy/methods , Tomography, X-Ray Computed , Oral Surgical Procedures/methods , Diphosphonates/therapeutic use , Maxillary Sinus/surgery , Multiple Myeloma
8.
Rev. Ciênc. Plur ; 7(2): 107-118, maio 2021. tab, graf
Article in Portuguese | LILACS, BBO | ID: biblio-1282976

ABSTRACT

Introdução:Os tumores de cabeça e pescoço têm expressiva incidência e mortalidade, assim comoalta letalidade, e constituem um relevante problema de saúde pública, particularmente nos países em desenvolvimento. Dentre as neoplasias malignas diagnosticadas no mundo, aproximadamente 10% estão localizadas na boca, sendo esse o sexto tipo de câncer mais incidente. Objetivo:Avaliar o perfil epidemiológico de pacientes diagnosticados com câncer de boca e faringe da Liga Mossoroense de Estudos e Combate ao Câncer do município de Mossoró, Rio Grande do Norte,Brasil,entre janeiro 2013 e junho de 2018.Metodologia:Estudo transversal, fundamentado na análise retrospectiva e descritiva de prontuários médicos.Resultados:Dos221 prontuáriosanalisados, a cor branca (56,6%) e o gênero masculino (70,6%) foram os mais prevalentes, com média de idade entre 55 e65 anos. A maioria (61,9%) apresentava ensino fundamental incompleto, sendo residentes de área urbana (59,6%) com histórico de uso de tabaco (64,6%) e/ou bebidas alcoólicas (53,9%). Osítio mais prevalente de câncer em boca foi a base da língua (12,7%).Conclusões:Conhecer o perfil dos pacientes com câncer de boca e orofaringe é um importante passo para melhor traçar e direcionar ações de saúde pública visando tanto àprevenção quanto o diagnóstico precoce (AU).


Introduction:Head and neck tumors have a significant incidence and mortality, as well as high lethality, and are a relevant public health problem, particularly in developing countries. Among the malignant neoplasms diagnosed in the world, approximately 10% are located in the mouth, this being the sixth most frequent type of cancer. Objective:To evaluate the epidemiological profile of patients diagnosed with oral and pharyngeal cancer of the Mossoroense League of Studies and Cancer Fighting in the municipality of Mossoró, Rio Grande do Norte, Brazil,between January 2013 and June 2018.Methodology:Cross-sectional study, based on retrospective and descriptive analysis of medical records.Results:Of the 221 records analyzed, white (56.6%) and male (70.6%) were the most prevalent, with a mean age between 55 and 65 years. Most (61.9%) had incomplete primary education, being residents of an urban area (59.6%) with a history of tobacco use (64.6%) and / or alcoholic beverages (53.9%).The most prevalent site of cancer in the mouth was the base of the tongue (12.7%). Conclusions:Knowing the profile of patients with oral and oropharyngeal cancer is an important step to better outline and direct public health actions aimed at both prevention and early diagnosis (AU).


Introducción: Los tumores de cabeza y cuello tienen una expresiva incidencia y mortalidad, así como alta letalidad, y constituyen un relevante problema de salud pública, especialmente en los países en desarrollo. Entre las neoplasias malignas diagnosticadas en el mundo,aproximadamente el 10% están localizadas en la boca, siendo este el sexto tipo de cáncer más común.Objetivo: Evaluar el perfil epidemiológico de pacientes diagnosticados con cáncer de boca y faringe de la Liga Mossoroense de Estudos e Combate ao Câncer del municipio de Mossoró, Rio Grande do Norte, Brasil,entre enero de 2013 y junio de 2018.Metodologia: Estudio transversal, basado en el análisis retrospectivo y descriptivo de los registros médicos.Resultados: De los 221 registros analizados, blancos (56,6%) y varones (70,6%) han sido los más prevalentes, con una media de edad entre 55 y 65 años. La mayoría (61,9%) presentaba educación primaria incompleta, siendo residentes de área urbana (59,6%) con antecedentes de uso de tabaco (64,6%) y/o bebidas alcohólicas (53,9%). El sitio más prevalente de cáncer en boca fuelabase de la lengua (12,7%). Conclusiones: Conocer el perfil de los pacientes con cáncer de boca y orofaringe es un importante paso para mejor delinear y dirigir acciones de salud pública objetivando tanto la prevención como el diagnóstico precoz (AU).


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Health Profile , Brazil/epidemiology , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Early Diagnosis , Medical Records , Cross-Sectional Studies/methods , Data Interpretation, Statistical , Qualitative Research
9.
Rev. Ciênc. Méd. Biol. (Impr.) ; 20(1): 144-148, maio 5, 2021. ilus
Article in Portuguese | LILACS | ID: biblio-1355095

ABSTRACT

Introdução: o sistema de saúde brasileiro enfrenta um importante desafio com o aumento da incidência e taxa de letalidade das doenças crônicas não transmissíveis. Entre elas encontra-se o câncer de cavidade oral que se desenvolve com a interação de múltiplos fatores, especialmente de ordem ambiental, evitáveis, que são instalados muitas vezes durante a adolescência. Objetivo: realizar revisão de literatura referente à prevalência, em adolescentes, de fatores comportamentais de risco que podem levar ao desenvolvimento do câncer oral. Metodologia: foi realizada revisão narrativa a fim de levantar os principais trabalhos referentes à temática. O levantamento bibliográfico foi conduzido através de bases de dados on-line, referente ao período de 2008 a 2018, utilizando os descritores: fatores de risco comportamentais, adolescentes, câncer oral, tabaco, álcool, HPV, e dieta de forma combinada, nos idiomas português e inglês. Foram incluídos aqueles documentos que apresentaram as expressões utilizadas nas buscas no título ou palavras-chave, ou tinham explícito no resumo que o texto estava relacionado ao tema, dentro da temporalidade especificada. Resultados e Discussão: foram identificados 12 artigos sobre o tema que apontaram como principais fatores comportamentais desenvolvidos na adolescência o tabagismo, o alcoolismo, e os comportamentos sexuais e alimentares, os quais representam importantes fatores de riscos na instalação do câncer oral. Conclusão: é consenso na literatura a necessidade, na maioria dos casos, de acumulação temporal dos fatores etiológicos desta doença, tendo assim a adolescência como uma fase promissora para o estabelecimento de hábitos saudáveis ou nocivos para a saúde do indivíduo.


Introduction: the Brazilian health system faces an important challenge with the increasing incidence and case fatality rate of c chronic diseases. These include oral cavity cancer that develops through the interaction of multiple, especially environmental, preventable factors that often develop during adolescence. Objective: to review the literature regarding the prevalence in adolescents of behavioral risk factors that may lead to the development of oral cancer. Metodology: narrative review was performed in order to survey the main works related to the theme. The literature review was conducted through online databases, from 2008 to 2018, using the descriptors: behavioral risk factors, adolescents, oral cancer, tobacco, alcohol, HPV, and diet in a combined manner, in Portuguese and English. We included those documents that presented the expressions used in the search in the title or keywords, or had explicit in the abstract that the text was related to the theme, within the specified temporality. Results and Discussion: twelve articles on the topic were identified that pointed as the main behavioral factors developed in adolescence, smoking, alcoholism, and sexual and eating behaviors, which represent important risk factors in the onset of oral cancer. Conclusion: there is a consensus in the literature on the need, in most cases, for the temporal accumulation of the etiological factors of this disease, thus having adolescence as a promising phase for the establishment of healthy or harmful habits for the individual's health.


Subject(s)
Humans , Male , Female , Adolescent , Mouth Neoplasms , Risk Factors , Adolescent , Tobacco Use Disorder , Review , Database , Alcoholism
10.
Odontol. Clín.-Cient ; 20(1): 8-11, jan.-mar. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1367970

ABSTRACT

Dentre as doenças mais letais em todo o Brasil, o câncer encontra-se como um dos principais, podendo se desenvolver em diversas áreas. Com relação ao câncer bucal, ele é considerado um dos mais prevalentes. Podendo ser justificado em decorrência do estilo de vida adotado por muitos, como tabagismo, alcoolismo, má alimentação e exposição excessiva ao sol. Produzindo um aumento no número de casos de forma progressiva. Em grande parte dos casos de câncer bucal, há o aparecimento de lesões potencialmente malignas, destacando-se a leucoplasia, eritroplasia e queilite actínica. A queilite actínica, decorrente do excesso de radiação ultravioleta, é uma lesão potencialmente maligna, altamente prevalente em pessoas que estão propensas a esta exposição sendo frequente em áreas cuja atividade econômica está pautada na agricultura, que requer exposição à radiação solar, como o noroeste do Paraná. Portanto, é essencial que todos os profissionais de saúde saibam reconhecer este como sendo um fator causador do câncer bucal e fiquem atentos às mudanças que ocorrem previamente à malignização, principalmente, lesões em lábios, onde a queilite manifesta-se. Logo, é importante que os profissionais saibam reconhecê-la precocemente, devendo ser vislumbrado já durante a universidade. Sendo assim, o objetivo do presente trabalho é avaliar o conhecimento de acadêmicos de diferentes áreas da saúde, sobre sinais e sintomas da queilite actínica, que é uma das lesões cancerizáveis mais importantes e prevalentes... (AU)


Among the most lethal diseases in Brazil, cancer is one of the main and can develop in several areas. Re garding oral cancer, it is considered one of the most prevalent. It can be justified due to the lifestyle adopt ed by many, such as smoking, alcoholism, poor diet and excessive sun exposure. Producing an increase in the number of cases in a progressive way. In most cases of oral cancer, there is the appearance of poten tially malignant lesions, highlighting the leukoplakia and actinic cheilitis. Actinic cheilitis, resulting from excess ultraviolet radiation, is a potentially malignant lesion, highly prevalent in people who are prone to this exposure being frequent in areas whose economic activity is based on agriculture, which requires exposure to solar radiation, such as the northwest Paraná. Therefore, it is essential that all health professionals know how to recognize this as a factor causing oral cancer and be aware of the changes that occur prior to malignancy, especially lip lesions, where cheilitis manifests. Therefore, it is important that profes sionals know how to recognize it early, and should be glimpsed already during the university. Therefore, the objective of this work is to evaluate the knowledge of scholars from different health areas about signs and symptoms of actinic cheilitis which is one of the most important and prevalent cancerizable lesions... (AU)


Subject(s)
Mouth Neoplasms , Cheilitis , Students, Dental , Health Knowledge, Attitudes, Practice , Solar Radiation , Life Style
11.
Odontol. Clín.-Cient ; 20(1): 85-89, jan.-mar. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1368451

ABSTRACT

O odontoma é uma alteração definida como um tumor odontogênico benigno e representa cerca de 70% das ocorrências dos tumores odontogênicos. O objetivo desse estudo foi apresentar um caso clínico referente ao diagnóstico e tratamento de um odontoma complexo em região anterior de maxila. Paciente de 27 anos compareceu à clínica buscando avaliação de rotina e, ao exame clínico, foi verificada a ausência dos elementos dentais 13 e 14 e retenção prolongada do 54. Radiograficamente, foi observada a presença de uma lesão radiopaca sugestiva de odontoma complexo, além de impactação dos elementos dentais 13 e 14. A abordagem adotada foi a remoção da lesão, do elemento 54 e tracionamento ortodôntico do elemento 13. A cirurgia foi feita em ambiente ambulatorial, sob anestesia local, iniciando pela exodontia do elemento 54, logo depois foi feita a incisão de Newman, descolamento mucoperiostal e remoção da lesão com broca cirúrgica esférica em alta rotação, sob refrigeração abundante com soro fisiológico estéril. Posteriormente, foi acessado o elemento 13 por vestibular e feito o desgaste ósseo com broca cirúrgica esférica, até a exposição da coroa do dente. Por fim, foi realizada a colagem do dispositivo de tracionamento ortodôntico, botão associado a fio de aço colocado com resina composta e o paciente foi encaminhado ao ortodontista. O diagnóstico e tratamento desse tipo de patologia é de suma importância, evitando implicações estéticas e funcionais ao paciente. Não é comum recorrências, e tem prognóstico excelente... (AU)


Odontoma is an alteration defined as a benign odontogenic tumor and represents about 70% of the oc currences of odontogenic tumors. The aim of this study was to present a clinical case regarding the diag nosis and treatment of a complex odontoma in the anterior region of the maxilla. A 27-year-old patient came to the clinic seeking routine evaluation and, on clinical examination, the absence of dental elements 13 and 14 and prolonged retention of 54 were verified. Radiographically, the presence of a radiopaque lesion suggestive of a complex odontomawas observed, in addition to impaction of dental elements 13 and 14. The approach adopted was the removal of the lesion, element 54 and orthodontic traction of element 13. The surgery was performed in an outpatient setting, under local anesthesia, starting with the extraction of element 54, shortly afterwards Newman's incision, mucoperiosteal detachment and removal of the lesion with a high-speed spherical surgical drill, under abundant refrigeration with sterile saline. Subsequently, element 13 was accessed through the vestibular and bone wear was done with a spherical surgical drill, until the tooth crown was exposed. Finally, the orthodontic traction device was bonded, a button associated with steel wire placed with composite resin and the patient was referred to the ortho dontist. The diagnosis and treatment of this type of pathology is extremely important, avoiding aesthetic and functional implications for the patient. Recurrences are not common and have an excellent prognosis... (AU)


Subject(s)
Humans , Male , Adult , Tooth Abnormalities , Odontogenic Tumors , Odontoma , Mouth Neoplasms
12.
Rev. cir. traumatol. buco-maxilo-fac ; 21(1): 36-39, jan.-mar. 2021. ilus
Article in English | LILACS, BBO | ID: biblio-1254737

ABSTRACT

The Polymorphous Low Grade Adenocarcinoma (PLGA) is a common minor salivary gland carcinoma. It mostly affects the buccal mucosa and retromolar region, but the palate is an unusual site. As the carcinoma is low grade the recurrence is also uncommon. Our patient had a PLGA initially in the palate which was treated initially through surgical management but had a recurrence after four years. Hence we planned a partial maxillectomy along with level I nodes. Post-operatively follow-up is successful till date. So the management of a recurrent PLGA through careful surgery and post-operative follow ­up with prosthetic rehabilitation is discussed in this article... (AU)


Subject(s)
Humans , Female , Aged , Salivary Glands, Minor , Mouth Neoplasms , Adenocarcinoma , Mouth Mucosa , Palate , Recurrence
13.
Acta méd. colomb ; 46(1): 27-33, ene.-mar. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1278152

ABSTRACT

Resumen Propósito: determinar la efectividad de detección de lesiones orales potencialmente malignas de cuatro métodos por medio de revisión sistemática tipo paraguas. Fuente de los datos: la búsqueda fue realizada con bases de datos Pubmed y EBSCOhost. Restricción de los años 2013-2018. Estrategia de búsqueda: (early detection of cáncer) AND (mouth neoplasms), (early detection of cáncer) AND (diagnostic techniques and procedures), (mouth neoplasms) AND (diagnostic techniques and procedures). Selección de los estudios: fueron seleccionadas a través de lectura crítica y la lista de chequeo del formato PRISMA, aquellas revisiones sistemáticas cuyo objetivo sea evaluar la efectividad de al menos uno de los métodos de detección de lesiones orales potencialmente malignas, seis estudios cumplieron con los criterios de inclusión. Extracción de datos: mediante la realización de lectura crítica de las revisiones sistemáticas seleccionadas previamente. Resultado de síntesis de los datos: se determina la efectividad a través de la comparación de las medias de porcentajes de sensibilidad y especificidad. Las medias de sensibilidad y especificidad de Vizilite fueron de 81.31 y 25.4%, de Microlux DL de 82.63 y 69.52%, de azul de toluidina de 82.07 y 66.27% y de citología exfoliativa de 76.77 y 80.87%, respectivamente. Conclusiones: los métodos de detección de lesiones orales premalignas evaluados en el presente estudio requieren mayor respaldo de evidencia científica para validar su efectividad. El método con mayor eficacia es el Microlux/DL, debido a sus altos niveles de sensibilidad y especificidad.


Abstract Objective: to determine the effectiveness of four methods for detecting potentially malignant oral lesions through an umbrella systematic review. Source of data: the search was performed in the PubMed and EBSCOhost databases. Years of search limited to 2013-2018. Search strategy: (early detection of cancer) AND (mouth neoplasms), (early detection of cancer) AND (diagnostic techniques and procedures), (mouth neoplasms) AND (diagnostic techniques and procedures). Study selection: using critical reading and the PRISMA checklist, systematic reviews with the objective of evaluating the effectiveness of at least one of the detection methods for potentially malignant oral lesions were selected; six studies met the inclusion criteria. Data extraction: through critical reading of the previously selected systematic reviews. Results of data synthesis: effectiveness was determined by comparing the mean percentages of sensitivity and specificity. Vizilite's sensitivity and specificity means were 81.31 and 25.4%, Microlux DL's were 82.63 and 69.52%, toluidine blue's were 82.07 and 66.27%, and exfoliative cytology's were 76.77 and 80.87%, respectively. Conclusions: the detection methods for pre-malignant oral lesions evaluated in this study need greater scientific evidence to validate their effectiveness. The method with the greatest effectiveness is Microlux/DL, due to its high levels of sensitivity and specificity.


Subject(s)
Mouth Neoplasms , Early Detection of Cancer , Sensitivity and Specificity , Diagnostic Techniques and Procedures , Cell Biology
14.
J. oral res. (Impresa) ; 10(1): 1-8, feb. 24, 2021. tab
Article in Spanish | LILACS | ID: biblio-1282715

ABSTRACT

Objective: Biopsy is the gold standard for the diagnosis of oral lesions. Correct management and care of biopsy at all steps (before, during and after obtaining a biopsy) is highly important to provide proper tissue samples for microscopic assessment by pathologists. This study aimed to assess and compare the knowledge of dental students (DSs) and general dentists (GDs) on post-oral biopsy instructions. Material and Methods: A questionnaire including two parts was used: 1) Demographic data and self-evaluation of biopsy knowledge by the participants and 2) 11 items about the correct oral biopsy storage and transport to a histopathology laboratory. The data collected from the questionnaires were analyzed by STATA. Results: 48 GDs and 131 DSs participated in this study. The knowledge score of the DSs (5.43±2.01) was significantly lower than GDs (8.33±1.78) (p<0.05). Moreover, there was no significant relationship between GDs' knowledge and their working experience, age, gender and the university they graduated from. However, there was a significant relationship between DSs' school year and their knowledge. Conclusion: The findings showed that the knowledge of DSs was lower than GDs. Since, these students will care for the oral and dental health of the community in the future, upgrading their training (by improving the quantity and quality of theoretical and practical training) is necessary to both understand the different aspects of biopsy, and to be familiar enough with proper oral biopsy storage and transport processes.


Objetivo: La biopsia es el estándar de oro para el diagnóstico de lesiones bucales. El manejo y cuidado correctos de la biopsia durante todos los pasos (antes, durante y después de obtener una biopsia) es muy importante para proporcionar muestras de tejido adecuadas para la evaluación microscópica por parte de los patólogos. Este estudio tuvo como objetivo evaluar y comparar los conocimientos de estudiantes de odontología (SD) y dentistas generales (GD) sobre las instrucciones posteriores a la biopsia oral. Material y Métodos: Se utilizó un cuestionario que constaba de dos partes: 1) Datos demográficos y autoevaluación del conocimiento de la biopsia por parte de los participantes y 2) 11 ítems sobre el correcto almacenamiento y transporte de la biopsia oral a un laboratorio de histopatología. STATA analizó los datos recopilados de los cuestionarios. Resultados: 48 GD y 131 SD participaron en este estudio. La puntuación de conocimiento de los DS (5,43 ± 2,01) fue significativamente menor que la de los GD (8,33 ± 1,78) (p <0,05). Además, no hubo una relación significativa entre los conocimientos de los GD y su experiencia laboral, edad, género y la universidad de la que se graduaron. Sin embargo, hubo una relación significativa entre el año escolar de los DS y sus conocimientos. Conclusión: Los hallazgos mostraron que el conocimiento de los SD era menor que el de los GD. Dado que estos estudiantes se ocuparán de la salud bucodental de la comunidad en el futuro, es necesario mejorar su formación (mejorando la cantidad y calidad de la formación teórica y práctica) tanto para comprender los diferentes aspectos de la biopsia como para estar familiarizados suficientemente con los procesos adecuados de almacenamiento y transporte de biopsias orales.


Subject(s)
Humans , Students, Dental , Biopsy , Dentists/education , Education, Dental , Mouth Neoplasms , Cross-Sectional Studies , Surveys and Questionnaires , Knowledge
15.
Article in English | WPRIM | ID: wpr-887755

ABSTRACT

OBJECTIVES@#To investigate the expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia (OLK) and OLK cancerization who have aspicy diet in Chengdu.@*METHODS@#Thirtypatients with OLK andspicy diet and 15 patients with OLK without spicy diet in Chengdu were divided into three groups: hyperplastic OLK (OLK-), OLK with mild to moderate dysplasia (OLK+), and severe dysplastic  OLK or oral squamous cell carcinoma (OSCC) transforming from OLK (OLK++/OSCC). The expression of Ki-67, Cyclin D1, P53, and P16 were detected by immunohistochemistry and statistically analyzed.@*RESULTS@#The expression of Ki-67 and P53 in patients with or without spicy diet in the OLK+and OLK++/OSCC groups were stronger than that of the OLK- group (@*CONCLUSIONS@#Spicy diet did not have an influence on the expression of Ki-67, Cyclin D1, P53, and P16 in patients with OLK and OSCC. The expression of Ki-67, Cyclin D1, and P53 increased with the development of OLK, whereas P16 showed opposite expression trend.


Subject(s)
Carcinoma, Squamous Cell , Cyclin D1 , Diet , Head and Neck Neoplasms , Humans , Ki-67 Antigen , Leukoplakia, Oral , Mouth Neoplasms , Tumor Suppressor Protein p53
16.
Article in English | WPRIM | ID: wpr-887754

ABSTRACT

OBJECTIVES@#To investigate the effects of circ_0005379 on the proliferation, apoptosis, migration, and invasion of oral squamous cell carcinoma (OSCC) cells and its mechanism.@*METHODS@#Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression levels of circ_0005379 and miR-17-5p in OSCC tissues and SCC15 cell lines. Western blot was used to detect the expression levels of acyl-CoA oxidase 1 (ACOX1). The circ_0005379 overexpression vector was transfected into SCC15 cells. Methyl thiazolyl tetrazolium blue staining, flow cytometry, Transwell, and Western blot were used to detect the effects of circ_0005379 overexpression on the proliferation, apoptosis, migration, and invasion of SCC15 cells and the expression of E-cadherin, β-catenin, and Snail proteins. Dual luciferase reporter assay and RNA immunoprecipitation were used to examine the regulation of circ_0005379, miR-17-5p, miR-17-5p, and ACOX1 in SCC15 cells. A nude mouse xenograft model of SCC15 cells stably overexpressing circ_0005379 was established, and the effect of circ_0005379 overexpression on the growth of xenografts in nude mice was observed.@*RESULTS@#Compared with adjacent cancer tissues, the expression levels of circ_0005379 and ACOX1 proteins in OSCC tissues were decreased (@*CONCLUSIONS@#circ_0005379 may inhibit the proliferation, migration, and invasion of OSCC cells by downregulating the expression of miR-17-5p and upregulating ACOX1, which promote apoptosis and inhibit tumor growth


Subject(s)
Acyl-CoA Oxidase , Animals , Carcinoma, Squamous Cell/genetics , Cell Proliferation , Head and Neck Neoplasms , Humans , Mice , Mice, Nude , MicroRNAs , Mouth Neoplasms/genetics , RNA, Circular , Squamous Cell Carcinoma of Head and Neck
17.
Article in English | WPRIM | ID: wpr-880867

ABSTRACT

Neck dissection for oral squamous-cell carcinoma (OSCC) is a clinically controversial issue and has therefore been the subject of abundant research. However, no one has performed a bibliometric study on this topic to date. The aim of this study was to assess the development of research on neck dissection for OSCC in terms of the historical evolution, current hotspots and future directions, particularly including research trends and frontiers from 2010 to 2019. Literature records related to research on neck dissection for OSCC were retrieved from the Web of Science Core Collection (WoSCC). CiteSpace was used as a tool to perform a bibliometric analysis of this topic. The survey included 2 096 papers. "Otorhinolaryngology" was the most popular research area. The most active institutions and countries were Memorial Sloan Kettering Cancer Center and the USA, respectively. Shah J.P. was the most cited author. Among the six identified "core journals", Head & Neck ranked first. The top three trending keywords were 'invasion', 'upper aerodigestive' and 'negative neck'. 'D'Cruz AK (2015)' was the most cited and the strongest burst reference in the last decade. The study evaluated the effect on survival of elective versus therapeutic neck dissection in patients with lateralized early-stage OSCC. The depth of invasion and the management of N0 OSCC were research frontiers in this field. The present study provides a comprehensive bibliometric analysis of research on neck dissection for OSCC, which will assist investigators in exploring potential research directions.


Subject(s)
Bibliometrics , Carcinoma, Squamous Cell/surgery , Head and Neck Neoplasms , Humans , Mouth Neoplasms/surgery , Neck Dissection
18.
Article in English | WPRIM | ID: wpr-880866

ABSTRACT

As an important component of the tumor microenvironment, cancer-associated fibroblasts (CAFs) secrete energy metabolites to supply energy for tumor progression. Abnormal regulation of long noncoding RNAs (lncRNAs) is thought to contribute to glucose metabolism, but the role of lncRNAs in glycolysis in oral CAFs has not been systematically examined. In the present study, by using RNA sequencing and bioinformatics analysis, we analyzed the lncRNA/mRNA profiles of normal fibroblasts (NFs) derived from normal tissues and CAFs derived from patients with oral squamous cell carcinoma (OSCC). LncRNA H19 was identified as a key lncRNA in oral CAFs and was synchronously upregulated in both oral cancer cell lines and CAFs. Using small interfering RNA (siRNA) strategies, we determined that lncRNA H19 knockdown affected proliferation, migration, and glycolysis in oral CAFs. We found that knockdown of lncRNA H19 by siRNA suppressed the MAPK signaling pathway, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and miR-675-5p. Furthermore, the lncRNA H19/miR-675-5p/PFKFB3 axis was involved in promoting the glycolysis pathway in oral CAFs, as demonstrated by a luciferase reporter system assay and treatment with a miRNA-specific inhibitor. Our study presents a new way to understand glucose metabolism in oral CAFs, theoretically providing a novel biomarker for OSCC molecular diagnosis and a new target for antitumor therapy.


Subject(s)
Cancer-Associated Fibroblasts/metabolism , Carcinoma, Squamous Cell/genetics , Cell Line, Tumor , Cell Proliferation , Gene Expression Regulation, Neoplastic , Glycolysis , Head and Neck Neoplasms , Humans , MicroRNAs/metabolism , Mouth Neoplasms/genetics , Phosphofructokinase-2/genetics , RNA, Long Noncoding/genetics , Signal Transduction , Tumor Microenvironment
19.
Article in English | WPRIM | ID: wpr-880864

ABSTRACT

C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our study was to investigate the relationship between ceramide synthase 1 and oral cancer. In this study, we found that the expression of ceramide synthase 1 was downregulated in oral cancer tissues and cell lines. In a mouse oral squamous cell carcinoma model induced by 4-nitroquinolin-1-oxide, ceramide synthase 1 knockout was associated with the severity of oral malignant transformation. Immunohistochemical studies showed significant upregulation of PCNA, MMP2, MMP9, and BCL2 expression and downregulation of BAX expression in the pathological hyperplastic area. In addition, ceramide synthase 1 knockdown promoted cell proliferation, migration, and invasion in vitro. Overexpression of CERS1 obtained the opposite effect. Ceramide synthase 1 knockdown caused endoplasmic reticulum stress and induced the VEGFA upregulation. Activating transcription factor 4 is responsible for ceramide synthase 1 knockdown caused VEGFA transcriptional upregulation. In addition, mild endoplasmic reticulum stress caused by ceramide synthase 1 knockdown could induce cisplatin resistance. Taken together, our study suggests that ceramide synthase 1 is downregulated in oral cancer and promotes the aggressiveness of oral squamous cell carcinoma and chemotherapeutic drug resistance.


Subject(s)
Animals , Apoptosis , Carcinoma, Squamous Cell , Cell Line, Tumor , Down-Regulation , Endoplasmic Reticulum Stress , Head and Neck Neoplasms , Mice , Mouth Neoplasms , Oxidoreductases
20.
Article in English | WPRIM | ID: wpr-880862

ABSTRACT

Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary; however, only a few patients with OSCC respond to this treatment. Therefore, it is essential to gain insights into the molecular mechanisms underlying the growth and metastasis of OSCC. In this study, we analysed the expression levels of protein kinase D3 (PKD3) and PD-L1 and their correlation with the expression of mesenchymal and epithelial markers. We found that the expression of PKD3 and PD-L1 in OSCC cells and tissues was significantly increased, which correlated positively with that of mesenchymal markers but negatively with that of epithelial markers. Silencing PKD3 significantly inhibited the growth, metastasis and invasion of OSCC cells, while its overexpression promoted these processes. Our further analyses revealed that there was positive feedback regulation between PKD3 and PD-L1, which could drive EMT of OSCC cells via the ERK/STAT1/3 pathway, thereby promoting tumour growth and metastasis. Furthermore, silencing PKD3 significantly inhibited the expression of PD-L1, and lymph node metastasis of OSCC was investigated with a mouse footpad xenograft model. Thus, our findings provide a theoretical basis for targeting PKD3 as an alternative method to block EMT for regulating PD-L1 expression and inhibiting OSCC growth and metastasis.


Subject(s)
Animals , B7-H1 Antigen/metabolism , Carcinoma, Squamous Cell , Cell Line, Tumor , Feedback , Head and Neck Neoplasms , Humans , Mice , Mouth Neoplasms , Protein Kinase C , STAT1 Transcription Factor , Squamous Cell Carcinoma of Head and Neck
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