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1.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1358295

ABSTRACT

Objetivo: compreender as principais complicações ocasionadas pelo vírus SARS-CoV-2 no sistema cardíaco do público idoso. Métodos: trata-se de uma revisão sistemática da literatura de abordagem qualitativa e característica descritivo-exploratória realizada no ano de 2020. Resultados: as complicações cardíacas mais prevalentes na população idosa foram miocardite, arritmias, insuficiência cardíaca, infarto agudo, choque cardiogênico, lesão miocárdica aguda e parada cardiorrespiratória. O principal biomarcador cardíaco foi a troponina, apresentando elevação superior ao percentil 99°, evidenciando a necessidade de tratamento em Unidade de Terapia Intensiva. Considerações Finais: o aparecimento desse vírus causou grande prejuízo no campo da saúde, especialmente a população idosa, que apresenta risco elevado de óbito ao contrair essa doença. Destarte, é de extrema importância se ater a mensuração da troponina sérica no público alvo e realizar monitorização longitudinal, utilizando para tal a telecardiologia, uma vez que diminuem as chances de contaminação entre infectado e profissional de saúde


Objective: to understand the main complications of SARS-CoV-2 in the elderly cardiac system. Methods: systematic literature review conducted in 2020. Results: the most prevalent cardiac complications in the elderly population were myocarditis, arrhythmias, heart failure, acute infarction, cardiogenic shock, acute myocardial injury and cardiorespiratory arrest. The main cardiac biomarker was troponin, showing an elevation above the 99th percentile, evidencing the need for treatment in the Intensive Care Unit. Final Considerations: the appearance of this virus has caused great damage in the health field, especially the elderly population, who is at high risk of death when contracting this disease. Therefore, it is important to stick to the measurement of serum troponin in the target audience and perform longitudinal monitoring, using telecardiology for this purpose, since they reduce the chances of contamination between infected and health professionals


Objetivo: comprender las principales complicaciones del SARS-CoV-2 en el sistema cardíaco anciano. Métodos: revisión sistemática de la literatura realizada en 2020. Resultados: las complicaciones cardíacas más prevalentes en la población anciana fueron miocarditis, arritmias, insuficiencia cardíaca, infarto agudo, shock cardiogénico, lesión miocárdica aguda y parada cardiorrespiratoria. El principal biomarcador cardíaco fue la troponina, mostrando una elevación por encima del percentil 99, evidenciando la necesidad de tratamiento en la Unidad de Cuidados Intensivos. Consideraciones finales: la aparición de este virus ha provocado un gran daño en el campo de la salud, especialmente en la población anciana, que se encuentra en alto riesgo de muerte al contraer esta enfermedad. Por tanto, es importante ceñirse a la medición de troponina sérica en el público objetivo y realizar un seguimiento longitudinal, utilizando para ello la telecardiología, ya que reducen las posibilidades de contaminación entre los infectados y los profesionales sanitarios


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Troponin , Health of the Elderly , COVID-19/complications , Heart Diseases/etiology , Patient Care Team , Shock, Cardiogenic , Telecardiology , Heart Arrest , Heart Failure , Intensive Care Units , Myocarditis
5.
In. Machado Rodríguez, Fernando; Cluzet, Óscar; Liñares Divenuto, Norberto Jorge; Gorrasi Delgado, José Antonio. La pandemia por COVID-19: una mirada integral desde la emergencia del hospital universitario. Montevideo, Cuadrado, 2021. p.109-120, ilus.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1344074
7.
Rev. urug. cardiol ; 36(3): e703, 2021. ilus
Article in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1367086

ABSTRACT

La miopericarditis aguda es una pericarditis aguda con compromiso miocárdico menor. En las primeras horas de evolución el cuadro clínico puede confundirse con un síndrome coronario agudo, en especial cuando el electrocardiograma presenta elevación del segmento ST y marcadores de necrosis miocárdica elevados. La resonancia magnética cardíaca tiene un papel importante para diferenciar las dos enfermedades. Presentamos el caso de un hombre de 36 años de edad ingresado por dolor de pecho, elevación del segmento ST y de marcadores de necrosis miocárdica. Se realiza angiografía coronaria, que no evidencia lesiones angiográficamente significativas, resonancia magnética cardíaca con contraste de gadolinio, en la que se observa leve derrame pericárdico, presencia de edema y realce tardío con patrón parcheado subepicárdico e intramiocárdico en pared lateral. Los hallazgos del estudio confirman el diagnóstico de miopericarditis.


Acute myopericarditis is an acute pericarditis with minor myocardial compromise. During the first hours from onset the clinical presentation can be confused with an acute coronary syndrome, especially when the electrocardiogram presents with ST segment elevation and increased markers of myocardial necrosis. Cardiac magnetic resonance imaging plays an important role to differentiate between these two diseases. We present the case of a 36-year-old male who was admitted with chest pain, ST segment elevation and increased markers of myocardial necrosis. Coronary angiography is performed reporting no significant angiographic findings. Cardiac magnetic resonance imaging with contrast medium (gadolinium) is performed, reporting mild pericardial effusion, presence of edema, and delayed uptake with a subepicardial and intramyocardial patchy pattern on the lateral wall. These test findings confirm the diagnosis of myopericarditis.


A miopericardite aguda é uma pericardite aguda com pequena deterioração miocárdica. Nas primeiras horas de evolução do quadro clínico podem ser confundidas com síndrome coronariana aguda, principalmente quando o eletrocardiograma mostra supradesnivelamento do segmento ST e marcadores elevados de necrose miocárdica. A ressonância magnética cardíaca desempenha um papel importante em distinguir as duas doenças. Apresentamos o caso de um homem de 36 anos admitido por dor torácica, supradesnivelamento do segmento ST e elevação dos marcadores de necrose miocárdica, foi realizada cineangiocoronariografia, onde não foram evidenciadas lesões angiograficamente significativas. Foi realizada a ressonância magnética cardíaca com contraste de gadolínio e foram observados derrame pericárdico leve, edema e realce tardio com um padrão irregular subepicárdico e intramiocárdico na face lateral. Os resultados do estudo confirmam o diagnóstico de miopericardite.


Subject(s)
Humans , Male , Adult , Pericarditis/diagnostic imaging , Magnetic Resonance Imaging , Acute Coronary Syndrome/diagnostic imaging , Gadolinium , Myocarditis/diagnostic imaging , Chest Pain , Acute Disease , Coronary Angiography , Diagnosis, Differential , Electrocardiography
8.
Rev. Soc. Bras. Med. Trop ; 54: e07892020, 2021. graf
Article in English | LILACS | ID: biblio-1155595

ABSTRACT

Abstract Covid-19 is a novel infectious disease whose spectrum of presentation ranges from absence of symptoms to widespread interstitial pneumonia associated with severe acute respiratory syndrome (SARS), leading to significant mortality. Given the systemic pattern of Covid-19, there are many factors that can influence patient's functional capacity after acute infection and the identification of such factors can contribute to the development of specific rehabilitation strategies. Pulmonary impairment is the primary cause of hospitalization due to Covid-19, and can progress to SARS as well as increase length of hospitalization. Moreover, cardiac involvement is observed in approximately 30% of hospitalized patients, with an increased risk of acute myocarditis, myocardial injury, and heart failure, which may compromise functional capacity in the long-term. Thromboembolic complications have also been reported in some patients with Covid-19 and are associated with a poor prognosis. Musculoskeletal complications may result from long periods of hospitalization and immobility, and can include fatigue, muscle weakness and polyneuropathy. Studies that address the functional capacity of patients after Covid-19 infection are still scarce. However, based on knowledge from the multiple systemic complications associated with Covid-19, it is reasonable to suggest that most patients, especially those who underwent prolonged hospitalization, will need a multiprofessional rehabilitation program. Further studies are needed to evaluate the functional impact and the rehabilitation strategies for patients affected by Covid-19.


Subject(s)
Humans , Coronavirus Infections , Heart Failure , Myocarditis , Betacoronavirus , Hospitalization
9.
Alger. J. health sci. (Online. Oran) ; 3(3): 88-94, 2021. Tables, figures
Article in English | AIM, AIM | ID: biblio-1292605

ABSTRACT

L'expansion planétaire du covid19 représente une crise sans précèdent ; cette pandémie a fait plus d'un million de mort en une année. En plus de l'atteinte pulmonaire, le virus a des implications majeures sur le système cardiovasculaire : les maladies cardiovasculaires pré existantes représentent un facteur de risque d'infection sévère avec augmentation de la mortalité, d'autre part l'infection entraine des complications cardiovasculaires qui aggravent le pronostic. Le lien entre le Covid19 et le système cardiovasculaire découle principalement de la voie d'entrée cellulaire du virus qui est assurée par sa liaison à une protéine membranaire l'enzyme de conversion de l'angiotensine (ECA), qui joue un rôle clé dans la régulation neurohumorale ; cette protéine est très présente au niveau du cœur et du poumon, d'où le tropisme du virus qui entraine la dysrégulation de cette voie cellulaire avec des répercussion sur la fonction cardiaque et respiratoire. Une polémique a déferlé concernant les traitements anti hypertenseurs et notamment les inhibiteurs du système rénine angiotensine aldostérone mais après évaluation des données actuelles, il est de consensus de ne pas arrêter ou changer les traitements anti hypertenseurs. L'augmentation des troponines cardiaques est un facteur de mauvais pronostic qui aggrave le tableau. La myocardite est définie par une inflammation myocardique, Les tableaux cliniques sont variables de la forme légère à la forme grave ; les biomarqueurs myocardiques restent un test incontournable en cas de suspicion clinique, le pronostic est incertain avec des formes fulminantes qui peuvent régresser et enfin pour le traitement les corticoïdes semblent être efficaces. Une autre complication du virus sont les accidents thrombo-emboliques et le dilemme occasionné par le risque accru aux thromboses et la thrombopénie induite par l'utilisation de l'héparine (TIH). On note une augmentation de l'incidence des syndromes coronaires aigus chez les sujets atteints du covid19.


The global expansion of covid19 represents a global crisis; this pandemic killed more than a million people in one year. In addition to pulmonary involvement, the virus has major implications on the cardiovascular system: pre-existing cardiovascular diseases represent a risk factor for severe infection with increased mortality, on the other hand the infection causes cardiovascular complications which worsen the prognosis. The link between the Covid19 and the cardiovascular system stems primarily from the virus's cellular entry pathway, which is provided by its binding to a membrane protein, the angiotensin converting enzyme (ACE) wich plays a key role in neurohumoral regulation; this protein is very present in the heart and lungs, hence the tropism of the virus which causes the dysregulation of this cellular pathway with repercussions on cardiac and respiratory function. A controversy broke out concerning the antihypertensive treatments and in particular the inhibitors of the renin angiotensin aldosterone system but after evaluation of the current data, there is a consensus not to withhold or change the treatments. The increase in cardiac troponins is a factor of poor prognosis which worsens the picture. Myocarditis is defined by myocardial inflammation, its clinical form ranges from the mild form to the severe one; the myocardial biomarkers remain an essential when the clinical suspicion rise, the prognosis is uncertain with fulminant forms which can regress; for treatment corticosteroids seem to be effective. Another complication of the virus are thromboembolic events and the dilemma caused by the increased risk of thrombosis and thrombocytopenia induced by the use of heparin (TIH), and there is an increase in the incidence of acute coronary syndromes in patients affected by covid19.


Subject(s)
COVID-19 , Thrombosis , Cardiovascular System , Algeria , COVID-19 Nucleic Acid Testing , Myocarditis
10.
Chinese Journal of Lung Cancer ; (12): 668-672, 2021.
Article in Chinese | WPRIM | ID: wpr-922239

ABSTRACT

Immune checkpoint inhibitors (ICIs) is a negative regulatory factor antibody, which activates T cells to play an anti-tumor effect in immunotherapy, and can also cause immune-related adverse responses, thereby inducing a series of immune related adverse events (irAEs). Among these irAEs, although the incidence of ICIs-related myocarditis is very low, the fatality rate is significantly higher than other adverse reactions, close to 50%. Clinicians should be vigilant when applying ICIs, but the pathogenesis of ICIs-related myocarditis is still unclear. This article combines the recent research results of ICIs to summarize the mechanism and clinical manifestations of ICIs-related myocarditis, so as to improve clinicians' understanding of the adverse reactions.
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Subject(s)
Biomedical Research/trends , Cardiotoxicity/physiopathology , Humans , Immune Checkpoint Inhibitors/therapeutic use , Immunotherapy/adverse effects , Myocarditis/physiopathology , Neoplasms/drug therapy
11.
Chinese Journal of Biotechnology ; (12): 3101-3107, 2021.
Article in Chinese | WPRIM | ID: wpr-921409

ABSTRACT

Viral myocarditis (VMC) is a disease characterized by inflammation of myocardial cells caused by viral infection. Since the pathogenesis mechanism of VMC has not been fully elucidated, the diagnosis and treatment of this disease remains extremely challenging. Non-coding RNAs (ncRNAs) are a class of RNAs that do not encode proteins. An increasing number of studies have shown that ncRNAs are involved in regulating the occurrence and development of VMC, thus providing potential new targets for the treatment and diagnosis of VMC. This review summarizes the possible roles of ncRNAs in the pathogenesis and diagnosis of VMC revealed recently.


Subject(s)
Coxsackievirus Infections , Enterovirus B, Human , Humans , Inflammation , Myocarditis/genetics , Virus Diseases/genetics
12.
CorSalud ; 12(4): 463-467, graf
Article in Spanish | LILACS | ID: biblio-1278964

ABSTRACT

RESUMEN Las manifestaciones cardiológicas del dengue son muy variadas, el virus puede penetrar al miocardio y producir una miocarditis aguda que, en ocasiones, puede pasar inadvertida y cursar de manera asintomática, con una evolución benigna; y en otras, puede producir alteraciones electrocardiográficas de trastornos del ritmo y la conducción o signos de disfunción ventricular que pueden llegar a la insuficiencia cardíaca grave. Se presenta el caso de un hombre de 21 años de edad, estudiante, con historia previa de salud, que ingresó en el Servicio de Cardiología con diagnóstico de dengue, confirmado por serología, complicado con un trastorno de la conducción (bloqueo aurículo-ventricular de grado avanzado 2:1) en relación a una miocarditis aguda por dengue. Este problema puede observarse en áreas en las que el dengue constituye un problema emergente, por lo que es de vital importancia su conocimiento para diseñar estrategias de prevención y tratamiento de las complicaciones.


ABSTRACT Dengue's cardiological manifestations are diverse; the virus is able to enter the myocardium and cause acute myocarditis that sometimes may go unnoticed and be asymptomatic, with benign outcomes; while in others, it may produce electrocardiographic rhythm and conduction disturbances or signs of ventricular dysfunction that could lead to severe heart failure. We present the case of a 21-year-old man, a student, previously healthy, who was admitted to the Department of Cardiology with a diagnosis of dengue confirmed by serology and complicated with conduction disorders (2:1 advanced atrioventricular block) related to acute myocarditis due to dengue. This problem can be seen in areas where dengue is an emerging problem. Therefore it is critical to be aware of it in order to design strategies for prevention and treatment of complications.


Subject(s)
Dengue , Atrioventricular Block , Myocarditis
13.
CorSalud ; 12(4): 458-462, graf
Article in Spanish | LILACS | ID: biblio-1278963

ABSTRACT

RESUMEN El dengue es una enfermedad viral febril aguda produci da por el virus del dengue, trasmitido, principalmente, por la picadura de mosquitos del género Aedes. Puede cursar con o sin síntomas, hasta ocasionar cuadros clínicos graves. Se presenta el caso de un hombre de 47 años de edad, que ingresó por fiebre de tres días de evolución, erupción cutánea (rash), náuseas, tos seca y lipotimias. Dos días después empeoró la erupción y apareció bradicardia extrema. El ecocardiograma demostró disfunción del ventrículo izquierdo, con fracción de eyección de 38%. El paciente fue egresado a 14 días con el diagnóstico de dengue complicado con miocarditis. Es evidente que fue una miocarditis viral desde el comienzo de los síntomas, descrita como inusual en la literatura; la tos y las lipotimias fueron la expresión del bajo gasto cardíaco, que unidas a la bradicardia y las alteraciones electro y ecocardiográficas, ayudaron a establecer el diagnóstico.


ABSTRACT Dengue is an acute febrile viral disease produced by the dengue virus, mainly transmitted by the bite of mosquitoes of the genus Aedes. It can take place with or without symptoms and it can cause serious clinical conditions. The case of a 47-year-old man is presented, who was admitted due to fever of three days of evolution, skin rash, nauseas, dry cough and lipothymias. Two days later, the rash worsened and extreme bradycardia appeared. The echocardiogram showed left ventricular dysfunction, with an ejection fraction of 38%. The patient was discharged after 14 days with the diagnosis of dengue complicated by myocarditis. It is evident that it was a viral myocarditis from the beginning of symptoms, which is described as unusual in the bibliography; cough and lipothymias were the expression of the low cardiac output, that together with the bradycardia, and the electro- and echocardiographic alterations, helped to establish the diagnosis.


Subject(s)
Dengue , Myocarditis
14.
Rev. méd. hondur ; 88(2): 110-114, jul.-dic. 2020. graf, ilus
Article in Spanish | LILACS | ID: biblio-1152099

ABSTRACT

Antecedentes: El Lupus Eritematoso Sistémico es una enfermedad autoinmune, sistémica, que involucra diferentes órganos incluyendo el corazón. Una de las manifestaciones cardíacas más comunes es la pericarditis; sin embargo, también se pueden presentar otras formas de afectación cardiaca entre las que se incluye la enfermedad arterial coronaria, arteritis y enfermedad valvular. Una de las presentaciones raras del lupus eritematoso sistémico incluye la miocarditis y una vez sospechada, debe ser diagnosticada y tratada con prontitud para evitar consecuencias fatales para el paciente. Descripción del caso: Presentamos un caso de una paciente femenina de 31 años con historia de dolor torácico, fiebre, fatiga, alteraciones ecocardiográficas y niveles elevados de troponina, a quien se le diagnóstico miocarditis y confirmación de Lupus Eritematoso Sistémico. El manejo fue terapia anti-isquémica e inmunoreguladores, con respuesta terapéutica y evolución satisfactoria. Conclusión: La miocardiopatía clínicamente evidente rara vez es la manifestación inicial de Lupus Eritematoso Sistémico, aunque también puede presentarse en el curso de la enfermedad con disfunción ventricular izquierda, insuficiencia cardiaca aguda y edema pulmonar, es de progresión rápida y requiere de diagnóstico y atención temprana, manejo multidisciplinario para evitar complicaciones fatales...(AU)


Subject(s)
Humans , Female , Adult , Hypertension, Pulmonary , Lupus Erythematosus, Systemic/diagnosis , Heart Failure/complications , Myocarditis
16.
Rev. méd. Maule ; 35(1): 47-51, oct. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1366394

ABSTRACT

SarsCov2 infection produces a clinical syndrome known as COVID-19, which presents mainly respiratory manifestations and various conditions are associated with a higher rate of complications of this pathology, with acute cardiovascular syndrome by COVID-19 being a relatively common complication. In this article we will review the most frequent manifestations, the prognosis, the diagnostic and therapeutic approach of these.


Subject(s)
Humans , Cardiovascular Diseases/metabolism , Cardiovascular Diseases/epidemiology , Cardiovascular System/virology , COVID-19/epidemiology , Cardiovascular System/physiopathology , Risk Assessment , Heart Disease Risk Factors , COVID-19/virology , Myocarditis
17.
Rev. colomb. cardiol ; 27(5): 434-445, sep.-oct. 2020. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1289254

ABSTRACT

Resumen Objetivo: describir las características epidemiológicas, clínicas y microbiológicas de los pacientes que cursan con miocarditis por Enterobacterias. Métodos: se realizó una revisión sistemática de la literatura, en la que se incluyeron Pubmed, Ovid, Scopus, SciELO y LILACS sin exclusión por tipo de idioma. La población objetivo de estudio fueron los pacientes con diagnóstico de infección bacteriana por bacilo gram negativo mediante cultivo, técnicas moleculares o histopatología, y quienes presentaban biopsia de miocardio o, en su defecto, resonancia magnética cardiaca con hallazgos sugestivos de miocarditis. Resultados: se encontraron 742 artículos, de los cuales se incluyeron 24; en estos se reportaron 27 pacientes. La edad promedio fue de 31 años. El 81% de los pacientes eran de sexo masculino. El síntoma principal fue diarrea (80%), seguido de fiebre (53%) y dolor torácico (38%). El 37% de los pacientes fallecieron. El hallazgo más común en el electrocardiograma fue la elevación del segmento ST (36,7%). En quienes se realizó ecocardiograma se encontraron anormalidades en 50% de los casos, siendo más frecuente la disminución en la fracción de eyección. El microorganismo más común fue el Campylobacter jejuni, seguido por Salmonela sp. Conclusiones: la miocarditis causada por enterobacterias es más frecuente en pacientes adultos jóvenes de sexo masculino. Los síntomas gastrointestinales suelen estar presentes al momento de la presentación clínica. El diagnóstico requiere de alta sospecha clínica teniendo en cuenta que las anormalidades eléctricas y en ecocardiograma no se encuentran en todos los pacientes.


Abstract Objective: To describe the epidemiological, clinical, and microbiological characteristics of patients with myocarditis due to Enterobacteria. Methods: A systematic review was carried out on the literature, which included Pubmed, Ovid, Scopus, SciELO, and LILACS, with no exclusions due to language. The target population of the study were patients with a diagnosis of bacterial infection due to gram negative bacillus by means of a culture, or using molecular or histopathology technique. They also had to have had a myocardial biopsy or, if not, a cardiac magnetic resonance scan with findings suggestive of myocarditis. Results: Out of a total of 742 articles found, 24 of these, in which 27 patients were described, were included. The mean age was 31 years, and 81% were male. The main symptom was diarrhoea (80%), followed by fever (53%), and chest pain (38%). More than one-third (37%) of the patients died. The most common finding on the electrocardiogram (ECG) was elevation of the ST segment (36.7%). Abnormalities were found in 50% of the cases, on whom a cardiac ultrasound was performed, with a decrease in the ejection fraction being the most common. The most common microorganism was Campylobacter jejuni, followed by Salmonella spp. Conclusions: Myocarditis caused by enterobacteria is most common in young male patients. The gastrointestinal symptoms are usually present from the clinical onset. The diagnosis requires a high clinical suspicion, taking into account that the abnormalities in the ECG and cardiac ultrasound are not found in all patients.


Subject(s)
Humans , Male , Adult , Salmonella , Shigella , Enterobacteriaceae , Myocarditis , Vibrio , Yersinia , Campylobacter , Clostridium
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