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1.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 214-222, Jan.-Feb. 2021. tab
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1153052

ABSTRACT

Objetivou-se avaliar a influência da suplementação com minerais biocomplexados sobre a qualidade da carne de frangos da linhagem Label Rouge, de ambos os sexos, criados em sistema alternativo. O delineamento experimental foi inteiramente ao acaso (DIC), disposto em esquema fatorial (3x2), sendo três dietas (controle; 0,50ppm de selênio; 0,40ppm de cromo) e dois sexos. Para a estabilidade lipídica, foi utilizado o DIC, disposto em esquema fatorial (3x2x2), sendo três dietas, dois sexos e dois tempos de armazenamento (zero e 12 meses). Os parâmetros avaliados no peito e na coxa foram: pH final, cor (L* - luminosidade, a* - índice de vermelho, b* - índice de amarelo, C* - índice de saturação e h* - ângulo de tonalidade), perda de peso por cozimento (PPC), força de cisalhamento (FC) e estabilidade lipídica. Além disso, foram avaliadas a proporção das formas químicas da mioglobina da coxa e a quantificação do conteúdo de selênio no peito. Não houve efeito isolado da dieta sobre os parâmetros físicos e químicos do peito e da coxa e sobre a concentração de selênio no peito. As fêmeas apresentaram médias superiores de L* (57,57), b* (10,55) e C* (10,60) do peito; e os machos de L* (55,09) da coxa. Entre os machos, as aves alimentadas com a dieta controle e com cromo expressaram valores superiores de FC da coxa em relação às suplementadas com selênio; para o tratamento com cromo, os machos apresentaram média superior de FC da coxa e, em contrapartida, para o tratamento com selênio, as fêmeas manifestaram a maior média. As amostras submetidas ao período de 12 meses de armazenamento mostraram maiores valores de substâncias reativas ao ácido tiobarbitúrico (TBARS) em ambos os cortes. A suplementação com cromo e selênio biocomplexados não provocou alterações na qualidade da carne; as fêmeas demonstraram melhores atributos de qualidade da carne.(AU)


The objective of the present study was to evaluate the influence of the supplementation with biocomplexed minerals on the quality of the meat of label Rouge lineage chicken, of both genders, reared in an alternative system. The experimental design was completely randomized (CRD) in a factorial scheme (3x2), with three diets (control; 0.50ppm of selenium; 0.40ppm of chromium) and two genders. For lipid stability, the CRD arranged in a factorial scheme (3x2x2) was used, being three diets, two genders and two storage times (0 and 12 months). The parameters evaluated in the breast and in the thigh were: final pH, color (L* - luminosity, a* - red index, b* - yellow index, C* - saturation index and h* - tonality angle), weight loss per cooking (WLC), shear force (SF) and lipid stability. In addition, we evaluated the proportion of chemical forms of myoglobin of the thigh and the quantification of selenium content in the breast. There was no isolated effect of diet on the physical and chemical parameters of the breast and thigh and selenium concentration in the breast. Females had higher mean values of L* (57.57), b* (10.55) and C* (10.60) of the breast; and males of L* (55.09) of the thigh. Among males, poultry fed with the control diet and chromium showed higher SF values of the thigh than those supplemented with selenium; for the treatment with chromium, the males presented superior average of SF of the thigh and, in contrast, for the treatment with selenium, the females had the highest average. Samples submitted to the period of 12-month of storage showed higher values of substances reactive to thiobarbituric acid (TBARS) in both cuts. Supplementation with biocomplexed chromium and selenium did not cause changes in meat quality; females presented better attributes of meat quality.(AU)


Subject(s)
Animals , Selenium/administration & dosage , Chickens/growth & development , Chromium/administration & dosage , Meat/analysis , Myoglobin , Dietary Supplements/analysis , Animal Feed/analysis
2.
Rev. bras. cineantropom. desempenho hum ; 20(5): 391-401, Sept.-Oct. 2018. tab, graf
Article in English | LILACS | ID: biblio-977443

ABSTRACT

High-intensity intermittent exercise (HIIE) elicits large improvements in health and cardiorespiratory fitness (CRF). HIIE can be applied with calisthenics exercises to improve strength and endurance. The acute effects of high-intensity circuit training (HICT) considering different CRF on myological variables are unknown. The aim was measure acute effects of HICT in young women considering different levels of CRF. Twelve women were allocated in two groups, who achieve 41mLO2•kg-1•min-1 or more= High Physical Fitness (HPF, n=5) and who achieve less than 41mLO2•kg-1•min-1= Low Physical Fitness (LPF,n=7). Protocol: 2x4 sets of 20 seconds at maximum intensity (all-out fashion) interspersed with 10 seconds of passive rest (jumping jacks, squat and thrust using 2kg dumbbells, mountain climber, and burpees). Blood samples were collected before, immediately after, 15minutes, 30minutes, one hour and 24 hours after. Heart rate, serum myoglobin, lactate, and creatine kinase (CK) concentration were analyzed. The HR achieved 94.1±3.7% of HRmax for LPF and 104.5±20.3% for HPF, p=0.03. The mean of delta lactate was similar between groups. The highest myoglobin has reached at 1h after the exercise protocol, with 50.0±30.2 ng/mL for LPF and 36.9±9.25 ng/mL for HPF. The delta of total CK before and after the exercise protocol shows that the serum CK level in LPF was significantly higher than HPF group (p=0.042). HICT composed by calisthenic protocol produced elevated and similar effects on HRmax, serum lactate and myoglobin in the woman with HPF and LPF. However, LPF group presented higher muscle damage inferred by serum CK concentrations.


O exercício intermitente de alta intensidade(HIIE) melhora a saúde e a aptidão cardiorrespiratória(CRF). HIIE pode ser aplicado com exercícios calistênicos para melhorar a força e resistência. Os efeitos agudos do treinamento de alta intensidade(HICT) considerando diferentes CRF em variáveis miológicas são desconhecidos. O objetivo foi medir os efeitos agudos do HICT em mulheres jovens, considerando diferentes níveis de CRF. Elas foram alocadas pelo nível de VO2máx. em dois grupos, as que atingiram 41mLO2•kg-1•min-1 ou mais= alta aptidão física(HPF,n=5) e menos de 41mLO2•kg-1•min-1= baixo aptidão física(LPF,n=7). Protocolo: 2x4 séries de 20s com intensidade máxima (all-out) intercalados com 10s de repouso passivo (jumping jacks, squat and thrust usando halteres 2kg, mountain climber e burpees). Sangue foi coletado antes, zero, 15, 30min, 1h e 24hs depois. Foram analisadas, freqüência cardíaca, mioglobina sérica, lactato e creatina quinase (CK). A FC alcançou 94,1±3,7% da FCmax para LPF e 104,5±20,3% para HPF, p=0,03. A média do delta lactato foi semelhante entre os grupos. O pico de mioglobina foi 1h após o protocolo de exercício, com 50.0±30.2ng/mL para LPF e 36.9±9.25ng/mL para HPF. O delta de CK total antes e depois do protocolo de exercício mostra que o nível sérico de CK no LPF foi significativamente maior do que o grupo HPF(p=0,042). O HICT com exercícios calistênicos produziu efeitos elevados e semelhantes sobre FCmax, lactato sérico e mioglobina nas mulheres com alta e baixa aptidão física. No entanto, o grupo LPF apresentou maior dano muscular inferido pelas concentrações séricas de CK.


Subject(s)
Humans , Female , Adult , Sprains and Strains , High-Intensity Interval Training , Cardiorespiratory Fitness , Exercise , Physical Fitness , Lactic Acid , Creatine Kinase/blood , Myoglobin/blood
3.
Article in English | WPRIM | ID: wpr-691036

ABSTRACT

<p><b>PURPOSE</b>Macrophages are known to be important for healing numerous injured tissues depending on their functional phenotypes in response to different stimuli. The objective of this study was to reveal macrophage phenotypic changes involved in exercise-induced skeletal muscle injury and regeneration.</p><p><b>METHODS</b>Adult male Sprague-Dawley rats experienced one session of downhill running (16° decline, 16 m/min) for 90 min. After exercise the blood and soleus muscles were collected at 0 h, 6 h, 12 h, 1 d, 2 d, 3 d, 1 w and 2 w after exercise, separately.</p><p><b>RESULTS</b>It was showed that CD68 M1 macrophages mainly infiltrated into muscle necrotic sites at 1-3 d, while CD163 M2 macrophages were present in muscles from 0 h to 2 weeks after exercise. Using transmission electron microscopy, we observed activated satellite cells 1 d after exercise. Th1-associated transcripts of iNOS and Ccl2 were inhibited post exercise, while COX-2 mRNA was dramatically increased 12 h after running (p < 0.01). M2 phenotype marker Arg-1 increased 12 h and 3 d (p < 0.05, p < 0.01) after exercise, and Clec10a and Mrc2 were up-regulated in muscles 12 h following exercise (p < 0.05, p < 0.05).</p><p><b>CONCLUSION</b>The data demonstrate the dynamic patterns of macrophage phenotype in skeletal muscle upon eccentric exercise stimuli, and M1 and M2 phenotypes perform different functions during exercise-induced skeletal muscle injury and recovery.</p>


Subject(s)
Animals , Antigens, CD , Antigens, Differentiation, Myelomonocytic , Macrophages , Physiology , Male , Muscle, Skeletal , Wounds and Injuries , Pathology , Myoglobin , Blood , Phenotype , Physical Conditioning, Animal , Rats , Rats, Sprague-Dawley , Receptors, Cell Surface
4.
Article in English | WPRIM | ID: wpr-739199

ABSTRACT

PURPOSE: Rhabdomyolysis is a metabolic disorder in which the content of damaged muscle cells is released into plasma. Its manifestations include asymptomatic, myalgia, gross hematuria, and complications of acute kidney injury. Because of limited data on rhabdomyolysis in children, we performed this study to determine clinical characteristics of rhabdomyolysis in children. METHODS: We retrospectively reviewed the records of patients with rhabdomyolysis who were treated at the Pusan National University Children's hospital from January 2011 to July 2016. The diagnostic criteria were serum myoglobin level of ≥80 ng/mL, exclusive of acute myocardial injury, cardiac arrest, and brain damage. RESULTS: Forty-five patients were enrolled; mean age, 116±68 months. Of these, 35 were boys and 10 were girls. Twenty-six patients experienced myalgia and 12 patients showed gross hematuria. Among these, seven patients initially had both myalgia and gross hematuria. The most common causes of rhabdomyolysis were infection, physical exertion, prolonged seizures, metabolic abnormalities, and drug addiction. Acute kidney injury (AKI) was the most common complication, followed by disseminated intravascular coagulation. Thirty-seven patients improved with sufficient fluid supply but two patients underwent hemodialysis due to deterioration of kidney function. Gross hematuria, positive occult blood test, and positive urine protein were more common in patients with AKI than in those without AKI. CONCLUSIONS: In children, infection was the most common cause of rhabdomyolysis. Most patients recovered by sufficient fluid therapy. However, in severe cases, especially in patients with underlying kidney disease, hemodialysis may be necessary in the present study.


Subject(s)
Acute Kidney Injury , Brain , Child , Disseminated Intravascular Coagulation , Female , Fluid Therapy , Heart Arrest , Hematuria , Humans , Influenza, Human , Kidney , Kidney Diseases , Muscle Cells , Myalgia , Myoglobin , Occult Blood , Physical Exertion , Plasma , Renal Dialysis , Retrospective Studies , Rhabdomyolysis , Seizures , Substance-Related Disorders
5.
Article in English | WPRIM | ID: wpr-713554

ABSTRACT

PURPOSE: This study aimed to evaluate the clinical findings in pediatric rhabdomyolysis and the predictive factors for acute kidney injury (AKI) in Korean children. METHODS: Medical records of 39 Korean children, who were newly diagnosed with rhabdomyolysis from January 2008 to December 2015, were retrospectively analyzed. The diagnosis was made from the medical history, elevated serum creatinine kinase level >1,000 IU/L, and plasma myoglobin level >150 ng/mL. Patients with muscular dystrophy and myocardial infarction were excluded. RESULTS: The median patient age at diagnosis was 14.0 years (range, 3–18 years), and the male to female ratio was 2.5. The most common presenting symptom was myalgia (n=25, 64.1%), and 14 patients (35.9%) had rhabdomyolysis-induced AKI. Eighteen patients (46.2%) had underlying diseases, such as epilepsy and psychotic disorders. Ten of these patients showed rhabdomyolysis-induced AKI. The common causes of rhabdomyolysis were infection (n=12, 30.7%), exercise (n=9, 23.1%), and trauma (n=8, 20.5%). There was no difference in the distribution of etiology between AKI and non-AKI groups. Five patients in the AKI group showed complete recovery of renal function after stopping renal replacement therapy. The median length of hospitalization was 7.0 days, and no mortality was reported. Compared with the non-AKI group, the AKI group showed higher levels of peak creatinine kinase and myoglobin, without statistical significance. CONCLUSION: The clinical characteristics of pediatric rhabdomyolysis differ from those observed in adult patients. Children with underlying diseases are more vulnerable to rhabdomyolysis-induced AKI. AKI more likely develops in the presence of a high degree of albuminuria.


Subject(s)
Acute Kidney Injury , Adult , Albuminuria , Child , Creatinine , Diagnosis , Epilepsy , Female , Hospitalization , Humans , Male , Medical Records , Mortality , Muscular Dystrophies , Myalgia , Myocardial Infarction , Myoglobin , Phosphotransferases , Plasma , Psychotic Disorders , Renal Replacement Therapy , Retrospective Studies , Rhabdomyolysis
6.
Article in Chinese | WPRIM | ID: wpr-776418

ABSTRACT

To investigate the spectrum-activity relationship of Trichosanthis Fructus and Trichosanthis Fructus strip pieces for rat myocardial ischemia-reperfusion injury. HPLC fingerprints of Trichosanthis Fructus and Trichosanthis Fructus strip pieces were established, and the values of creatinekinase-MB (CK-MB), myoglobin (MYO) and cardiac troponin-T (cTNT) in 3 dose groups (2.25, 13.5, 27.0 g·kg⁻¹, equivalent to the crude herb g·kg⁻¹) of Trichosanthis Fructus and Trichosanthis Fructus strip pieces with myocardial ischemia-reperfusion injury in rats were measured, and the grey relational analysis was used to study the spectrum-activity relationship of Trichosanthis Fructus and Trichosanthis Fructus strip pieces for rat myocardial ischemia-reperfusion injury. With the dosage increase from 2.25 g·kg⁻¹ to 27.0 g·kg⁻¹, the correlation degree of spectrum-activity relationship of Trichosanthis Fructus and Trichosanthis Fructus strip pieces was also enhanced, but the change trend was different between these two groups. According to the frequency of the top 10 peaks in the correlation degree, peak 17, 14, 16, 19, 32, 12, 26, 30, 4, 6 and 2 were the basic effective substances group of Trichosanthis Fructus, peak 6,14,12,32,30,4 and 6 were the basic effective substances group of Trichosanthis Fructus strip pieces. Peak 6, 14, 12, 32, 30, 4 and 26 in fingerprints of Trichosanthis Fructus and Trichosanthis Fructus strip pieces were the main common pharmacodynamic substance base, among them, peak 6 was 5-hydroxymethyl furfural, peak 14 was vanillic acid and the peak 28 was rutin, but the correlation degree with the efficacy was different. The effect of Trichosanthis Fructus and Trichosanthis Fructus strip pieces on rat myocardial ischemia-reperfusion injury was due to the synergistic effect of the effective substance groups related to the dosage. The essential pharmacodynamic substance groups of Trichosanthis Fructus and Trichosanthis Fructus strip pieces were different, but they shared a common active ingredient group.


Subject(s)
Animals , Chromatography, High Pressure Liquid , Creatine Kinase, MB Form , Blood , Cucurbitaceae , Chemistry , Drugs, Chinese Herbal , Pharmacology , Fruit , Chemistry , Myocardial Reperfusion Injury , Drug Therapy , Myoglobin , Blood , Rats , Troponin T , Blood
7.
Article in English | WPRIM | ID: wpr-728858

ABSTRACT

PURPOSE: This study was performed to review the relationship between the clinical features and laboratory findings of patients suspected of benign acute childhood myositis (BACM) in children and adolescents with bilateral calf pain and gait disturbances. METHODS: From January 1, 2010 to December 31, 2016, the clinical and laboratory findings of patients who visited Dongguk University Ilsan Hospital with the sudden onset fever and muscle pain were retrospectively examined. RESULTS: The total number of patients was 29 (21 males and 8 females), and their mean age was 5.5 years. The mean duration of fever was 4.2 days. The mean duration from the onset of fever to show the symptom was 3.2 days. The mean recovery period from myositis was 2.4 days. The mean duration of hospitalization was 2.2 days. Fever and bilateral calf pain were the most common symptoms; however, cough, rhinorrhea, sore throat, headache, and abdominal pain were also observed. The causative agent of BACM was influenza B infection in 23 (79.3%) of the cases. Creatinine phosphokinase (CPK), myoglobin, aspartate aminotransferase (AST), and alanine transaminase (ALT) values were higher in the shorter duration of fever and were statistically significant. The following values were noted: CPK (r=−0.472), myoglobin (r=−0.472), AST (r=−0.443), and ALT (r=−0.459). The longer the pain period, the lower the white blood cell (WBC) count (r=−0.655). CONCLUSION: BACM is mostly associated with the influenza B virus. Time to onset of symptoms after fever and WBC levels are related to muscle enzyme levels and duration of symptoms in BACM.


Subject(s)
Abdominal Pain , Adolescent , Alanine Transaminase , Aspartate Aminotransferases , Child , Cough , Creatinine , Fever , Gait , Headache , Hospitalization , Humans , Influenza B virus , Influenza, Human , Leukocytes , Male , Myalgia , Myoglobin , Myositis , Pharyngitis , Retrospective Studies
8.
Braz. j. med. biol. res ; 51(8): e6921, 2018. graf
Article in English | LILACS | ID: biblio-951749

ABSTRACT

Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA. The arterial pressure and myocardial tissue velocities were also measured. The role of interleukin (IL)-6 in RUPP-associated myocardial damage was further explored. The results showed that RUPP rats had significant myocardial damage, as demonstrated by the high expressions of myoglobin, creatine kinase isoenzyme, cardiac troponin I, and brain natriuretic peptide. In addition, RUPP increased the mean arterial pressure and the early transmitral flow velocity to mitral annulus early diastolic velocity ratio (E/Ea). Furthermore, IL-6 deteriorated these abnormalities, whereas inhibition of IL-6 significantly relieved them. In conclusion, our study demonstrated that RUPP rats displayed myocardial damage in an IL-6-dependent manner.


Subject(s)
Animals , Female , Pregnancy , Pre-Eclampsia/metabolism , Interleukin-6/metabolism , Cardiomyopathies/etiology , Myocardium/metabolism , Perfusion , Pre-Eclampsia/etiology , Random Allocation , Interleukin-6/antagonists & inhibitors , Rats, Sprague-Dawley , Echocardiography, Doppler, Color , Troponin I/metabolism , Natriuretic Peptide, Brain/metabolism , Disease Models, Animal , Creatine Kinase, MB Form/metabolism , Antibodies, Monoclonal, Humanized/administration & dosage , Antibodies, Monoclonal, Humanized/metabolism , Arterial Pressure , Heart/drug effects , Heart/diagnostic imaging , Cardiomyopathies/metabolism , Cardiomyopathies/pathology , Myoglobin/metabolism
9.
Rev. Assoc. Med. Bras. (1992) ; 63(10): 904-909, Oct. 2017. tab, graf
Article in English | LILACS | ID: biblio-896298

ABSTRACT

Summary Objective: To investigate the changes in serum cardiac myosin light chain 1 (CMLC-1) levels in children with fulminant myocarditis (FM) during continuous blood purification (CBP), as well as to analyze its correlation with other laboratory indexes. Method: Twenty-four (24) children with FM who underwent CBP were enrolled. Before and during treatment (48 and 72 hours after treatment, or death), the optical density value of serum CMLC-1 was measured using enzyme-linked immunosorbent assay, and then the serum CMLC-1 concentration was calculated. The correlations between CMLC-1 OD value change and laboratory indexes including creatine kinase-MB (CK-MB), troponin, myohemoglobin and N-terminal pro-brain natriuretic peptide (NT-proBNP) were analyzed. Results: The serum CMLC-1 concentration significantly increased in the children with FM and decreased obviously during CBP therapy. In the same period, the change of CMLC-1 concentration were positively correlated with creatine kinase-MB (r=0.528), troponin (r=0.726), myohemoglobin (r=0.702), and NT-proBNP levels (r=0.589). Conclusion: The serum CMLC-1 concentration increases significantly in children with FM, but CBP therapy can effectively control this increase.


Subject(s)
Humans , Child , Hemofiltration/methods , Myosin Light Chains/blood , Myocarditis/blood , Myocarditis/therapy , Peptide Fragments/blood , Reference Values , Time Factors , Troponin/blood , Enzyme-Linked Immunosorbent Assay , Biomarkers/blood , Statistics, Nonparametric , Natriuretic Peptide, Brain/blood , Creatine Kinase, MB Form/blood , Myoglobin/blood
10.
Article in Korean | WPRIM | ID: wpr-156754

ABSTRACT

We have evaluated the performance of a recently developed immunoassay analyzer, ADVIA Centaur XPT (Siemens, Germany). Precision, linearity, and comparison studies were performed according to the CLSI guidelines. The test items evaluated were ferritin, folate, human epidermal growth factor receptor 2/neu, homocysteine, vitamin B₁₂, B-type natriuretic peptide, creatine kinase–myocardial band, myoglobin, procalcitonin, troponin I. Bio-Rad control materials, linearity materials, and patients' samples were used for the evaluation. For the correlation study, ADVIA Centaur XP (Siemens) were used as comparative methods. The total coefficients of variations (CVs) of the analytes were between 2.5% and 7.0%. The results of linearity evaluation were also acceptable for the range tested. Correlations with comparative methods were good. The overall analytical performance of ADVIA Centaur XPT is acceptable for the immunology analyzer. Therefore, ADVIA Centaur XPT is expected to be widely used.


Subject(s)
Allergy and Immunology , Creatine , Ferritins , Folic Acid , Homocysteine , Humans , Immunoassay , Myoglobin , Natriuretic Peptide, Brain , ErbB Receptors , Statistics as Topic , Troponin I , Vitamins
11.
Article in English | WPRIM | ID: wpr-136736

ABSTRACT

PURPOSE: Virus-associated rhabdomyolysis is very rare. We report 15 patients with rhabdomyolysis caused by various viruses. METHODS: Fifteen patients who were diagnosed with rhabdomyolysis and a viral infection were included in this study. Clinical, laboratory, and radiologic findings were evaluated through retrospective chart reviews. RESULTS: Chief complaints were severe bilateral lower leg pain and leg weakness. The median age was 5.7 years. The male:female ratio was 2:5. The viral infections were caused by influenza virus B, parainfluenza virus, and rhinovirus. One patient with influenza virus B had coinfection with coronavirus. Median initial laboratory values and ranges were as follows:serum creatinine, 0.4 (0.1-0.5) mg/dL; serum aspartate transaminase, 124 (48-1,098) IU/L; serum alanine transaminase, 30 (16-1,455) IU/L; serum creatine kinase, 2,965 (672-16,594) IU; serum lactate dehydrogenase, 400 (269-7,394) IU/L; serum myoglobin, 644 (314-3,867) ng/mL; urine myoglobin, 3 (3-10,431) ng/mL. All patients recovered without complications. CONCLUSION: This is the first report of the simultaneous occurrence of rhabdomyolysis caused by various viruses. This is also the first report of rhinovirus-associated rhabdomyolysis.


Subject(s)
Alanine Transaminase , Aspartate Aminotransferases , Child , Coinfection , Coronavirus , Creatine Kinase , Creatinine , Humans , Influenza B virus , L-Lactate Dehydrogenase , Leg , Myoglobin , Orthomyxoviridae , Paramyxoviridae Infections , Retrospective Studies , Rhabdomyolysis , Rhinovirus
12.
Article in English | WPRIM | ID: wpr-136733

ABSTRACT

PURPOSE: Virus-associated rhabdomyolysis is very rare. We report 15 patients with rhabdomyolysis caused by various viruses. METHODS: Fifteen patients who were diagnosed with rhabdomyolysis and a viral infection were included in this study. Clinical, laboratory, and radiologic findings were evaluated through retrospective chart reviews. RESULTS: Chief complaints were severe bilateral lower leg pain and leg weakness. The median age was 5.7 years. The male:female ratio was 2:5. The viral infections were caused by influenza virus B, parainfluenza virus, and rhinovirus. One patient with influenza virus B had coinfection with coronavirus. Median initial laboratory values and ranges were as follows:serum creatinine, 0.4 (0.1-0.5) mg/dL; serum aspartate transaminase, 124 (48-1,098) IU/L; serum alanine transaminase, 30 (16-1,455) IU/L; serum creatine kinase, 2,965 (672-16,594) IU; serum lactate dehydrogenase, 400 (269-7,394) IU/L; serum myoglobin, 644 (314-3,867) ng/mL; urine myoglobin, 3 (3-10,431) ng/mL. All patients recovered without complications. CONCLUSION: This is the first report of the simultaneous occurrence of rhabdomyolysis caused by various viruses. This is also the first report of rhinovirus-associated rhabdomyolysis.


Subject(s)
Alanine Transaminase , Aspartate Aminotransferases , Child , Coinfection , Coronavirus , Creatine Kinase , Creatinine , Humans , Influenza B virus , L-Lactate Dehydrogenase , Leg , Myoglobin , Orthomyxoviridae , Paramyxoviridae Infections , Retrospective Studies , Rhabdomyolysis , Rhinovirus
13.
Article in English | WPRIM | ID: wpr-41572

ABSTRACT

Neuroleptic malignant syndrome (NMS) is a life-threatening idiosyncratic reaction that usually occurs after the administration of antipsychotic drugs. Antidepressants, benzodiazepines, and antiepileptic drugs are also suggested to be associated with NMS. It is believed to result from a dopaminergic blockade in the central nervous system. NMS is manifested by hyperthermia, muscle rigidity, autonomic dysfunction, altered mental status, leukocytosis, and elevated serum creatinine phosphokinase. Valproate is commonly used in the treatment of many psychiatric and neurologic disorders. Valproate can precipitate NMS, especially when used with antipsychotic drugs concurrently. A 17-year-old male patient, who presented with fever, muscular rigidity, confusion, sweating, and tachycardia was admitted to the emergency room. He had been taking only valproate for the last two months for bipolar disorder. His laboratory analyses revealed raised serum hepatic enzymes, creatinine phosphokinase, and myoglobin levels. Considering fever, rigidity, autonomic dysfunction, cognitive alteration, and high creatinine phosphokinase levels, the patient was diagnosed with NMS. In this paper, we aim to discuss the association between valproate and NMS.


Subject(s)
Adolescent , Anticonvulsants , Antidepressive Agents , Antipsychotic Agents , Benzodiazepines , Bipolar Disorder , Central Nervous System , Child , Creatinine , Emergency Service, Hospital , Fever , Humans , Leukocytosis , Male , Muscle Rigidity , Myoglobin , Nervous System Diseases , Neuroleptic Malignant Syndrome , Sweat , Sweating , Tachycardia , Valproic Acid
14.
Article in Korean | WPRIM | ID: wpr-209173

ABSTRACT

The STRATUS CS200 (Siemens Healthcare Diagnostics Inc., USA) has recently been developed as an on-site diagnostic instrument for assaying several kinds of cardiac markers within a short duration. The precision, linearity, comparison, limit of quantification, and turnaround time (TAT) were evaluated for troponin I, creatine kinase-MB (CK-MB), N-terminal pro-brain natriuretic peptide (NT-proBNP), and myoglobin assays according to guidelines provided by the Clinical and Laboratory Standards Institute. The total coefficients of variation of the four items were between 1.90% and 4.25%. All markers showed a linearity that was ≥0.99, and the values were within the manufacturer's range. All items showed a close correlation with E170 (Roche Diagnostics, Germany). The limits of quantification for troponin I, CK-MB, myoglobin, and NT-proBNP were 0.03 ng/mL, 0.3 ng/mL, 1 ng/mL, and 15 pg/mL, respectively. The TAT was 14 minutes. The performance of the STRATUS CS200 for assaying cardiac markers was highly satisfactory in terms of the precision, linearity, limit of quantification, and TAT, and it showed a good correlation with the comparative method.


Subject(s)
Creatine , Delivery of Health Care , Methods , Myoglobin , Troponin I
15.
Article in English | WPRIM | ID: wpr-727949

ABSTRACT

Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was additionally given UA supplementation (450 mg/day) for 8 weeks. Blood samples were obtained before and after intervention, and cortisol, BNP, myoglobin, CK, CK-MB, and LDH levels were analyzed. Subjects who underwent RT alone showed no significant change in body composition and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance. In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p<0.05). In conclusion, UA supplementation alleviates increased skeletal muscle damage markers after RT. This finding provides evidence for a potential new therapy for resistance-trained men.


Subject(s)
Adipose Tissue , Body Composition , Body Weight , Creatine , Creatine Kinase , Healthy Volunteers , Humans , Hydrocortisone , L-Lactate Dehydrogenase , Male , Muscle, Skeletal , Myoglobin , Natriuretic Peptide, Brain , Pilot Projects , Resistance Training
16.
Article in Korean | WPRIM | ID: wpr-219080

ABSTRACT

PURPOSE: In patients with altered mentality caused by drugs or unknown causes, ammonia is checked to facilitate differential diagnosis or diagnose hepatic coma. This helps early prevention and treatment of brain damage due to hyperammonemia. This study was conducted to evaluate clinical characteristics of intoxicated adult patients with hyperammonemia. METHODS: We evaluated 95 patients with hyperammonemia among intoxicated patients above the age of 15 who visited our ED from January 2013 to December 2015. We analyzed the demographic characteristics and type of poisoning substance, reason for ingestion, toxicological characteristics such as elapsed time from ingestion to hospital visit, lab, clinical progression and complications. Data were evaluated using the student's t test or Mann-Whitney U test for continuous variables, and Chi-square test and Fisher's exact test for frequency analysis of categorical variables. RESULTS: When compared to healthy individuals, patients with hyperammonemia showed statistical significance on their SOFA score (p=0.016) and poison severity score (p<0.001). Additionally, patients with hyperammonemia showed significantly different initial serum AST level (p=0.012) and maximum serum AST level during the hospital stay (p=0.026) when compared to healthy individuals. Moreover, individuals with sustained hyperammonemia compared to transient hyperammonemia showed clinically significant SOFA scores (p<0.001), poison severity scores (p=0.007), mortality rates in the ICU (p=0.021), as well as different duration of hospital stay (p=0.037), serum creatinine level (p=0.002), erythrocyte sedimentation rate (p=0.025), and serum myoglobin (p=0.015). CONCLUSION: Most poisoning-induced hyperammonemia cases were transient and recovered without special treatment. Therefore, hyperammonemia is almost non-specific among poisoning patients.


Subject(s)
Adult , Ammonia , Blood Sedimentation , Brain , Creatinine , Diagnosis, Differential , Eating , Hepatic Encephalopathy , Humans , Hyperammonemia , Length of Stay , Mortality , Myoglobin , Poisoning
17.
Rev. bras. epidemiol ; 18(1): 194-207, Jan-Mar/2015. tab
Article in Portuguese | LILACS | ID: lil-736436

ABSTRACT

OBJETIVO: Analisar os fatores pessoais associados à prevalência e duração dos benefícios auxílio-doença decorrentes de sinovite e tenossinovite (CID10 M65). MÉTODO: Estudo transversal referente aos benefícios auxílio-doença decorrentes de sinovite e tenossinovite concedidos pelo Instituto Nacional de Seguro Social aos empregados no Brasil em 2008. Dados sobre o ramo de atividade econômica (Classificação Nacional de Atividades Econômicas - CNAE divisão, classe), sexo, idade, espécie e duração dos benefícios foram coletados do Sistema Único de Benefícios. A população corresponde à média mensal dos vínculos empregatícios declarados ao Cadastro Nacional de Informações Sociais. RESULTADOS: Em 2008 foram concedidos 35.601 benefícios auxílio-doença decorrentes de sinovite e tenossinovite, com prevalência de 10,9/10.000 vínculos empregatícios. No conjunto dos benefícios auxílio-doença houve maior razão de prevalência (RP) acidentária (RP 1,2), sendo esta maior em mulheres (RP 3,3), e em trabalhadores com idade acima de 39 anos (RP 1,4). As CNAE 37-Esgoto (55,4) e 60-Atividade de rádio e TV (47,1) apresentaram as maiores prevalências, no entanto, 64-Atividade de serviços financeiros e 6422-Bancos múltiplos caracterizaram mais acidentes de trabalho (RP 3,2 e 3,8, respectivamente) e maior duração (70 e 73 dias, respectivamente). A maior duração de benefício ocorreu entre trabalhadores com idade superior a 39 anos. Tanto a CNAE-divisão 60-Atividade de rádio e TV, quanto a CNAE-classe 6010-Atividade de rádio apresentaram elevadas razões de feminilidade (RP 8,1 e 10,8, respectivamente). CONCLUSÃO: A incapacidade para o trabalho por sinovite e tenossinovite apresenta associação tanto da prevalência quanto da duração com o ramo de atividade, sexo, idade e espécie de benefício (previdenciário/acidentário). .


OBJECTIVE: To analyse the personal and occupational factors associated with the prevalence and duration of sickness benefit claims due to synovitis and tenosynovitis (CID10 M65). METHODS: Cross-sectional study regarding sickness benefit claims due to synovitis and tenosynovitis granted to employees by National Institute of Social Security in Brazil in 2008. Data on economic activity (Economic Activities National Classification - CNAE division, class), sex, age, type and duration of benefits were collected from the Unified Benefit System. The study's population consists of the average monthly employment contracts declared to the National Register of Social Information. RESULTS: In 2008, 35,601 employees were granted sickness benefits due to synovitis and tenosynovitis, with a prevalence of 10.9/10,000 employments. Sickness benefits showed higher prevalence rates (PR) for work-related claims (PR 1,2), mostly made by females (PR 3.3) and by workers older than 39 years (PR 1,4). The CNAE 37-Sewage (55.4) and 60-Broadcasting Activity (47.1) had the highest overall prevalence. However, the 64-Financial service activities, except insurance and pension funding and 6422-Multiple banks with commercial service had the highest rates of work-related claims (RP 3.2 and 3.8, respectively), and the longer duration (70 and 73 days, respectively). Workers older than 39 years had the highest durations of work disability claims. Both the CNAE-division 60-Broadcasting Activity, and the CNAE-class 6010-Radio showed a high activity ratio of females (PR 8.1 and 10.8, respectively). CONCLUSION: The work disability due to synovitis and tenosynovitis presents prevalence and duration associated with economic activity, sex, age and kind of benefit (non work-related and work-related claims). .


Subject(s)
Humans , Globins/chemistry , Hydrogen Peroxide/chemistry , Nerve Tissue Proteins/chemistry , Nitrites/chemistry , Amino Acid Sequence , Binding Sites , Catalysis , Cysteine/chemistry , Cysteine/metabolism , Disulfides/chemistry , Disulfides/metabolism , Globins/metabolism , Hydrogen Peroxide/metabolism , Kinetics , Models, Molecular , Molecular Sequence Data , Myoglobin/chemistry , Myoglobin/metabolism , Nerve Tissue Proteins/metabolism , Nitrites/metabolism , Oxidation-Reduction , Protein Conformation , Phenol/chemistry , Phenols/chemistry , Phenylacetates/chemistry , Tandem Mass Spectrometry
18.
Article in Korean | WPRIM | ID: wpr-135057

ABSTRACT

Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare cutaneous T-cell lymphoma. Most cases are composed of large anaplastic cells. However, it presents a wide spectrum of histologic patterns. In the small cell variant, a small-sized pleomorphic cell morphology can be seen. A 74-year-old woman presented with an 8-month history of asymptomatic ulcerative plaque and satellite nodule on the right calf. Her past medical history was not specific. The histologic findings on punch biopsy specimens showed a malignant small round cell tumor on both lesions. The tumor cells had large pleomorphic nuclei with multinucleation and some eosinophilic cytoplasm. We performed immunohistochemical staining to rule out neuroectodermal tumor, neuroendocrine tumor, melanoma, lymphoma, and so on. However, the staining results were negative for pancytokeratin, CD3, CD20, CD99, chromogranin A, synaptophysin, CD56, ALK, HMB45, desmin, kappa, lambda, myoglobin, and S-100 protein. CT, MRI, and PET-CT were negative for extracutaneous involvement. Total excision was done, and additional immunohistochemical staining was performed to confirm the origin of the tumor. Staining results for vimentin, LCA, CD4, and CD30 were positive. We concluded that these findings were consistent with the small cell variant CD30+ PCALCL, which occurs rarely.


Subject(s)
Aged , Biopsy , Chromogranin A , Cytoplasm , Desmin , Eosinophils , Female , Humans , Lymphoma , Lymphoma, Large-Cell, Anaplastic , Lymphoma, Primary Cutaneous Anaplastic Large Cell , Lymphoma, T-Cell, Cutaneous , Magnetic Resonance Imaging , Melanoma , Myoglobin , Neuroectodermal Tumors , Neuroendocrine Tumors , S100 Proteins , Synaptophysin , Ulcer , Vimentin
19.
Article in Korean | WPRIM | ID: wpr-135056

ABSTRACT

Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare cutaneous T-cell lymphoma. Most cases are composed of large anaplastic cells. However, it presents a wide spectrum of histologic patterns. In the small cell variant, a small-sized pleomorphic cell morphology can be seen. A 74-year-old woman presented with an 8-month history of asymptomatic ulcerative plaque and satellite nodule on the right calf. Her past medical history was not specific. The histologic findings on punch biopsy specimens showed a malignant small round cell tumor on both lesions. The tumor cells had large pleomorphic nuclei with multinucleation and some eosinophilic cytoplasm. We performed immunohistochemical staining to rule out neuroectodermal tumor, neuroendocrine tumor, melanoma, lymphoma, and so on. However, the staining results were negative for pancytokeratin, CD3, CD20, CD99, chromogranin A, synaptophysin, CD56, ALK, HMB45, desmin, kappa, lambda, myoglobin, and S-100 protein. CT, MRI, and PET-CT were negative for extracutaneous involvement. Total excision was done, and additional immunohistochemical staining was performed to confirm the origin of the tumor. Staining results for vimentin, LCA, CD4, and CD30 were positive. We concluded that these findings were consistent with the small cell variant CD30+ PCALCL, which occurs rarely.


Subject(s)
Aged , Biopsy , Chromogranin A , Cytoplasm , Desmin , Eosinophils , Female , Humans , Lymphoma , Lymphoma, Large-Cell, Anaplastic , Lymphoma, Primary Cutaneous Anaplastic Large Cell , Lymphoma, T-Cell, Cutaneous , Magnetic Resonance Imaging , Melanoma , Myoglobin , Neuroectodermal Tumors , Neuroendocrine Tumors , S100 Proteins , Synaptophysin , Ulcer , Vimentin
20.
Article in Korean | WPRIM | ID: wpr-44477

ABSTRACT

Rhabdomyolysis a clinical syndrome characterized by injury to skeletal muscle and release of intracellular contents into the systemic circulation, can develop from infections, although trauma is a more common cause. Myoglobinuric acute kidney injury (AKI) is a potentially life-threatening complication of rhabdomyolysis. Reports of rhabdomyolysis and AKI induced by salmonella infection are rare in the Korean literature. This paper describes a case of salmonella enteritis complicated by rhabdomyolysis and AKI. A 58-year-old man presented to the hospital with a two day history of watery diarrhea, abdominal pain and high fever. Initial blood chemistry revealed a serum creatinine (Cr) level of 3.4 mg/dL, with elevations of serum creatine phosphokinase (CK, 5,635 IU/L) and serum myoglobin (>3,000 ng/mL). Intravenous hydration and empirical antibiotic treatment with ciprofloxacin were initiated. Blood and stool cultures grew salmonella group B, which was sensitive to ciprofloxacin, ampicillin, and ceftazidime. Parenteral ciprofloxacin was continued for 14 days. During the first week of hospitalization, peak levels of serum Cr and CK were 9.5 mg/dL and 89,155 IU/L, respectively. Thereafter clinical and biochemical parameters gradually improved without dialysis. The patient was discharged on the 20th hospital day with normal CK levels except for serum Cr. His renal function normalized (serum Cr 1.0 mg/dL) two months after discharge. Based on the results of this case, prompt fluid therapy and early administration of antibiotics should be performed in patients with salmonella infection complicated by rhabdomyolysis and AKI.


Subject(s)
Abdominal Pain , Acute Kidney Injury , Ampicillin , Anti-Bacterial Agents , Ceftazidime , Chemistry , Ciprofloxacin , Creatine Kinase , Creatinine , Dialysis , Diarrhea , Enteritis , Fever , Fluid Therapy , Hospitalization , Humans , Middle Aged , Muscle, Skeletal , Myoglobin , Rhabdomyolysis , Salmonella Infections , Salmonella
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