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1.
Alerta (San Salvador) ; 5(1): 12-16, ene. 28, 2022. ilus
Article in Spanish | LILACS, BISSAL | ID: biblio-1354268

ABSTRACT

El neuroblastoma olfativo, también conocido como estesioneuroblastoma, es un tumor derivado de la capa basal del epitelio olfativo. Se presenta como una masa de tejido blando en la porción superior de la cavidad nasal que involucra las células de aire etmoides anteriores y medias en un lado y se extiende a través de la placa cribiforme en la fosa craneal anterior, es poco frecuente y representa menos del 3 % de las neoplasias intranasales. De acuerdo con la evolución epidemiológica, su distribución por edades es bimodal con un pico en pacientes adultos en la segunda década de la vida y otro en los quinta y sexta, sin existir predilección por género reconocida


Olfactory neuroblastoma, also known as esthesioneuroblastoma, is a tumor derived from the basal layer of the olfactory epithelium. It presents as a soft tissue mass in the upper portion of the nasal cavity that involves the anterior and middle ethmoid air cells on one side and extends through the cribriform plate in the anterior cranial fossa, it is rare and represents less 3% of intranasal neoplasms. According to the epidemiological evolution, its age distribution is bimodal with a peak in adult patients in the second decade of life and another in the fifth and sixth, with no recognized gender predilection


Subject(s)
Olfactory Mucosa , Esthesioneuroblastoma, Olfactory , Epithelium , Nasal Cavity , Patients , Air , Neoplasms
2.
Rev. Odontol. Araçatuba (Impr.) ; 42(1): 33-37, jan.-abr. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1252851

ABSTRACT

Durante a formação dentária, distúrbios de desenvolvimento podem acontecer, causando anomalias de número, forma, tamanho, estrutura e posição, além de apresentarem anormalidade no padrão sequencial de irrupção. Uma boa anamnese, associada a palpação e exames de imagens são indispensáveis para um diagnóstico precoce e favorável destas alterações. Os exames de imagem determinarão a relação espacial destes dentes com as estruturas nobres adjacentes. O objetivo deste trabalho é relatar a presença de supranumerário unilateral e impactação bilateral de caninos permanentes, ambas anomalias com proximidade da cavidade nasal e seio maxilar, ressaltando a importância do diagnóstico preciso através de exames clínico e de imagens, que direcionam o planejamento terapêutico específico para cada caso, bem como a associação multidisciplinar para obtenção de um resultado satisfatório do quadro e melhora da qualidade de vida do paciente(AU)


During dental formation, developmental disorders can occur, causing anomalies of number, shape, size and position, in addition to presenting abnormality in the sequential pattern of irruption. Anamnesis associated with palpation are indispensable for an early diagnosis of these alterations. Imaging exams will determine the spatial relationship between these teeth and the adjacent noble structures. The aim of this study was to report the presence of unilateral supernumerary and bilaterally impacted canines, both anomalies with proximity of nasal cavity and maxillary sinus, emphasizing the importance of accurate diagnosis through clinical and imaging exams, that direct the specific therapeutic planning for each case, as well as the multidisciplinary association to obtain satisfactory results and improve the life quality of patients(AU)


Subject(s)
Tooth, Supernumerary , Tooth, Unerupted/therapy , Tooth, Unerupted/diagnostic imaging , Activator Appliances , Cuspid , Maxillary Sinus , Medical History Taking , Nasal Cavity
3.
Arch. argent. pediatr ; 119(1): S48-S53, feb. 2021. tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1147363

ABSTRACT

Se define la epistaxis como el sangrado proveniente del vestíbulo, la cavidad nasal o la nasofaringe. Representa el 3 % de las consultas de guardia. El 30 % de los niños menores de 5 años presentan, al menos, un episodio de epistaxis. La edad media de presentación es entre los 7,5 y los 8,5 años. Predomina en el sexo masculino (el 56-67 %). La rinorrea es el síntoma más frecuentemente asociado (el 46 %). El origen puede ser anterior o posterior, y las anteriores son las más frecuentes. Es necesario un enfoque integral para determinar la etiología (primaria o secundaria). Los principales objetivos del tratamiento son el control de la hemorragia, de la causa subyacente y la prevención de la recurrencia.La mayoría de las hemorragias son autolimitadas; sin embargo, el taponamiento nasal y la cauterización son requeridos ante casos recurrentes o graves. Cuando estas técnicas fracasan, puede utilizarse un manejo endoscópico, angiografía-embolización y ligadura quirúrgica abierta


Epistaxis is defined as bleeding from the vestibule, nasal cavity or nasopharynx. It represents 3 % of Emergency Room consultations. Thirty per cent of children under 5 years of age have an episode of epistaxis. The average age of presentation is between 7.5 and 8.5 years. It predominates in males (56-67 %). Nasal obstruction (nasal discharge) is the most associated symptom (46 %). The origin can be anterior or posterior, with the previous ones being the most frequent. An integral approach is necessary to determine the etiology (primary or secondary). The main purposes of the treatment are bleeding control and the underlying cause and the prevention of recurrence. Most hemorrhages are self-limiting; however, nasal tamponade and cauterization are required in cases of recurrence and/or severity. When these techniques fail, endoscopic management, angiography-embolization, and open surgical ligation may be used.


Subject(s)
Humans , Child , Epistaxis/diagnosis , Epistaxis/etiology , Cautery , Epistaxis/classification , Epistaxis/therapy , Hemorrhage , Nasal Cavity
4.
Autops. Case Rep ; 11: e2021246, 2021. graf
Article in English | LILACS | ID: biblio-1153187

ABSTRACT

Extranodal NK/T-cell lymphoma, nasal type (ENKTL-NT) is a rare type of Non-Hodgkin's lymphoma, which usually presents with extranodal involvement and affects the nasal/upper aerodigestive tract in the classical presentation. Herein, we report the case of a 31-year-old, previously healthy, male patient diagnosed with ENKTL-NT with the involvement of the lung parenchyma and heart. Unfortunately, due to the rapid disease progression, the diagnosis was performed only at the autopsy. The authors highlight the rare clinical presentation of this type of lymphoma, as well as the challenging anatomopathological diagnosis in necrotic samples.


Subject(s)
Humans , Male , Adult , Nose Neoplasms/pathology , Lymphoma, Extranodal NK-T-Cell/pathology , Nasal Cavity/pathology , Autopsy , Lymphoma, T-Cell , Fatal Outcome , Herpesvirus 4, Human , Disease Progression , Heart , Lung/pathology
5.
Rev. CEFAC ; 23(4): e14020, 2021. tab, graf
Article in English | LILACS | ID: biblio-1287882

ABSTRACT

ABSTRACT Purpose: to analyze the correlation between the values of nasal aeration and geometry of the nasal cavities, before and after nasal cleansing in children with mouth breathing. Methods: 20 children aged 4 to 12 years old were chosen. The questionnaire Identification Index of Signs and Symptoms of Oral breathing was applied and nasal patency was assessed by nasal aeration, through the Altmann graded mirror, and the nasal geometry measured by acoustic rhinometry. After nasal cleansing and massage, the same aeration measurements and nasal geometry procedures were performed. Group normality was analyzed using the Shapiro-Wilk test considering the hypothesis of normal distribution whenever p>0.05. The Spearman's test was applied to analyze the correlation between variables (p<0.05). Results: there was a strong and significant correlation between nasal aeration and the corresponding cross-sectional area of the front of the inferior turbinate (CSA2) in the left cavity before cleansing. There were no correlations between the nasal aeration and other rhinometric variables. Conclusion: there was a correlation between nasal aeration values and the anterior portion of the turbinates, before the massage and nasal cleansing technique, in mouth breathing children. There were no significant differences when the nasal aeration was correlated with other rhinometric variables.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Rhinometry, Acoustic , Mouth Breathing/diagnosis , Nasal Cavity/physiopathology , Mouth Breathing/physiopathology
6.
Article in Spanish | LILACS, COLNAL | ID: biblio-1349481

ABSTRACT

El quiste dermoide es una lesión congénita poco frecuente, secundario a una regresión incompleta de tejido ectodérmico, y su incidencia es de 1/20 000-40 000 nacidos vivos. Debe realizarse una resección quirúrgica oportuna para prevenir el compromiso intracraneal y/o las complicaciones. El estudio imagenológico determina su extensión. Se han recomendado diferentes enfoques quirúrgicos, los cuales deben cumplir con los cuatro principios de Pollock. El siguiente estudio presenta el caso de un paciente pediátrico, de nueve meses de edad, con un quiste dermoide en la base del cráneo asociado con un trayecto fistuloso a punta nasal. La resonancia magnética nuclear (RMN) contrastada evidenció una masa quística en la región anterior a la crista galli comunicada con el tracto fistuloso a la punta nasal. El paciente fue llevado a cirugía para realizar la resección del quiste mediante rinoplastia externa combinada con abordaje endoscópico transnasal. Los resultados funcionales y estéticos fueron satisfactorios, sin recurrencia. Se evidenció una fístula de líquido cefalorraquídeo intraoperatoria corregida en el mismo tiempo quirúrgico.


The dermoid cyst is a rare congenital lesion, secondary to an incomplete regression of ectodermal tissue. Its incidence is 1/20,000-40,000 live births. Timely surgical resection must be performed to prevent intracranial involvement and/or complications. Imaging study determines its extension. Different surgical approaches have been recommended; all must adhere to Pollock's 4 principles. The following study presents the case of a pediatric patient, 9 months old, with a dermoid cyst at the skull base with a fistulous path to the nasal tip. Contrasted nuclear magnetic resonance revealed a cystic mass in the region anterior to the crista galli communicated with a fistulous tract at the nasal tip. The patient was taken to surgery for cyst resection by external rhinoplasty combined with a transnasal endoscopic approach with satisfactory functional and aesthetic results, without recurrence. A Cerebrospinal fluid fistula was evidenced, as an intraoperative complication, it was corrected in the same surgical time.


Subject(s)
Humans , Dermoid Cyst , Child, Preschool , Skull Base , Nasal Cavity
7.
Dental press j. orthod. (Impr.) ; 25(5): 51-56, Sept.-Oct. 2020. graf
Article in English | LILACS, BBO | ID: biblio-1133692

ABSTRACT

ABSTRACT Introduction: Nasal septum deviation (NSD) is the most common structural cause of nasal obstruction, affecting around 65-80% of the adult population. Rapid maxillary expansion (RME) is currently used for treatment of maxillary transverse deficiency, but can also influence nasal cavity geometry. Objective: The present study aimed at evaluating the changes in NSD by using Cone-Beam Computed Tomography (CBCT) scans in pre-pubertal patients treated with RME. Methods: This retrospective exploratory study evaluated 20 pre-pubertal patients (mean age 10 ± 2 years) who were treated for transverse maxillary constriction with RME and presented mild/moderate NSD as an incidental finding. The outcome measures were NSD tortuosity and area. These measures were obtained from transverse and coronal views of records taken before and after RME treatment. Intra-rater reliability was also assessed with intraclass correlation coefficient. Results: NSD was mild in thirteen patients (65%) and moderate in seven (35%). NSD tortuosity index did not significantly change over time (mean difference 0.002 mm/year, 95% CI; p = 0.58). NSD area did not significantly change over time (mean difference 2.103 mm2/year, 95% CI; p = 0.38). Intraclass correlation coefficient was 0.73 (95% CI) for NSD tortuosity and 0.84 (95% CI) for NSD area. Conclusions: NSD tortuosity and area suggested potential changes in NSD with small clinical relevance in pre-pubertal patients who were treated with RME. Additional studies using CBCT scans in larger samples are required to clarify the role of RME in NSD treatment.


RESUMO Introdução: O desvio de septo nasal (DSN) é a causa estrutural mais frequente de obstrução nasal, afetando de 65% a 80% da população adulta. A expansão rápida da maxila (ERM), atualmente utilizada para o tratamento da deficiência transversa da maxila, também pode influenciar na geometria da cavidade nasal. Objetivos: O presente estudo teve como objetivo avaliar, usando tomografia computadorizada de feixe cônico (TCFC), as mudanças no DSN após o tratamento com ERM em pacientes pré-púberes. Métodos: Esse estudo exploratório retrospectivo avaliou 20 pacientes pré-púberes (idade média de 10 ± 2 anos) com deficiência transversa da maxila tratados com ERM, e que apresentavam DSN de leve a moderado, como um achado incidental. Foram realizadas medições da tortuosidade e área do DSN. Essas medições foram feitas em cortes transversais e coronais das TCFCs pré- e pós-tratamento com ERM. A confiabilidade intraexaminador também foi aferida por meio do coeficiente de correlação intraclasse. Resultados: O DSN era leve em 13 pacientes (65%) e moderado em 7 (35%). O índice de tortuosidade do DSN não mudou significativamente ao longo do tempo (diferença média = 0,002 mm/ano, IC 95%; p= 0,58). A área do DSN não mudou significativamente ao longo do tempo (diferença média = 2,103 mm2/ano, IC 95%; p= 0,38). O coeficiente de correlação intraclasse foi igual a 0,73 (IC 95%) para a tortuosidade do DSN e 0,84 (IC 95%) para a área do DSN. Conclusões: Os valores de tortuosidade e da área do DSN sugeriram potenciais mudanças no DSN, mas com pequena relevância clínica, nos pacientes pré-púberes tratados com ERM. Estudos adicionais utilizando TCFC em amostras maiores são necessários para esclarecer o papel da ERM no tratamento do DSN.


Subject(s)
Humans , Child , Palatal Expansion Technique , Cone-Beam Computed Tomography , Reproducibility of Results , Retrospective Studies , Maxilla , Nasal Cavity/diagnostic imaging , Nasal Septum/diagnostic imaging
8.
Arq. bras. med. vet. zootec. (Online) ; 72(4): 1571-1575, July-Aug. 2020. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1131505

ABSTRACT

O objetivo deste estudo foi realizar a caracterização genética de Staphylococcus spp. resistentes a meticilina isolados de suínos. Foram coletadas 30 amostras de swab nasal de suínos, abatidos em um frigorífico com Serviço de Inspeção Federal. Os isolados foram submetidos a análises macro e microscópicas que, em seguida, para detectar a resistência bacteriana, foram submetidos a ensaios fenotípicos da sensibilidade aos antimicrobianos. Posteriormente, as amostras resistentes a oxacilina, foram submetidas à reação em cadeia pela polimerase (PCR) para verificar a presença do gene mecA. Das 30 amostras analisadas, foram isolados 12 (40%) Staphylococcus spp. coagulase positiva, e 18 (60%) coagulase negativa, e, dentre os isolados, 26 (86,66%) foram resistentes a oxacilina sendo possível detectar o gene mecA em seis (23%) amostras. Este estudo evidencia a presença de genes de resistência em microrganismos comuns a microbiota de animais de produção que podem ser transmitidos ao homem. Além de chamar a atenção para a frequência e quantidade de antimicrobianos aos quais estes animais são expostos durante toda sua vida, podendo ser considerado um problema para a saúde única.(AU)


Subject(s)
Animals , Swine/microbiology , Methicillin-Resistant Staphylococcus aureus/genetics , Nasal Cavity/microbiology , Refrigeration/veterinary , Polymerase Chain Reaction/veterinary , Preliminary Data
9.
Pesqui. vet. bras ; 40(8): 621-629, Aug. 2020. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1135666

ABSTRACT

This study aimed to quantify nasosinusal neoplasms diagnosed in dogs in 20 years (2000-2019) and characterize the main clinical, macroscopic, and histological aspects of these neoplasms. The sex, breed, age, skull conformation, the main clinical signs, and the anatomopathological characteristics (distribution, macroscopy, and histology) were computed. During this period, 49 dogs were affected by neoplasms in these regions, totaling 50 neoplasms (one dog had two neoplasms of different locations and histogenetic origins). Similar amounts of mixed-breed dogs (25/49) and purebred dogs (24/49) were affected, these distributed in 16 breeds. Among purebreds, it was noted that dogs with mesocephalic cranial conformation (12/24) were the most affected, followed by dolichocephalic (10/24) and brachycephalic (2/24). There were 22 cases in males and 27 in females, making a proportion of 1:1.23. There was an age variation from 11 months to 16 years old. The epithelial neoplasms have occurred in older dogs compared to those of other histogenic origins (mesenchymal and other origins/round cells). The main clinical signs were similar between the histogenetic categories, related to the involvement of the upper respiratory tract, sometimes accompanied by nervous signs (when there was brain invasion of nasal neoplasms or vice versa). The possible origin site was mostly in the nasal cavity concerning the paranasal sinuses (and other locations). Invasions occurred in different tissues adjacent to the nasal cavity and paranasal sinuses, resulting in cranial and facial deformities (21/49). The frequency was 48% of epithelial neoplasms, 32% of mesenchymal neoplasms, and 10% of neoplasms with other origins and round cells. The neoplasms most frequently observed, in decreasing order of frequency, were: adenocarcinoma (9/50), squamous cell carcinoma (9/50), transmissible venereal tumor (5/50), osteosarcoma (5/50), chondrosarcoma (4/50), and undifferentiated sarcoma (4/50). Through this study, it was possible to establish the frequency of these neoplasms in 20 years and their clinical, macroscopic, and histological characteristics.(AU)


Este estudo teve como objetivo quantificar os neoplasmas nasossinusais diagnosticados em cães em 20 anos (2000-2019) e caracterizar os principais aspectos clínicos, macroscópicos e histológicos desses neoplasmas. Foram computados sexo, raça, idade, conformação do crânio, principais sinais clínicos e características anatomopatológicas (distribuição, macroscopia e histologia). Nesse período, 49 cães foram acometidos por neoplasmas nessas regiões, totalizando 50 neoplasmas (um cão tinha dois neoplasmas de localização e origens histogenéticas distintas). Foram acometidas quantidades semelhantes de cães sem raça definida (25/49) e de cães com raça definida (24/49), estes distribuídos em 16 raças. Entre os cães com raça definida, notou-se que os cães com conformação craniana mesocefálica (12/24) foram os mais acometidos, seguidos pelos dolicocefálicos (10/24) e braquicefálicos (2/24). Foram observados 22 casos em machos e 27 em fêmeas, perfazendo a relação de 1:1,23. Ocorreu uma variação de idade de 11 meses a 16 anos; tendo os neoplasmas epiteliais ocorrido em cães mais velhos quando comparado aos de outras origens histogênicas (mesenquimais e outras origens/células redondas). Os principais sinais clínicos foram semelhantes entre as categorias histogenéticas, sendo relacionados ao comprometimento do trato respiratório superior, por vezes acompanhados de sinais nervosos (quando houve invasão encefálica de neoplasmas nasais ou vice-versa). O possível local de origem em sua maioria foi na cavidade nasal em relação aos seios nasais (e de outras localizações). Ocorreram invasões para diferentes tecidos adjacentes à cavidade nasal e seios paranasais, tendo como consequência deformidades cranianas e faciais (21/49). A frequência foi de 48% de neoplasmas epiteliais, 32% de neoplasmas mesenquimais e 10% de neoplasmas com outras origens e de células redondas. Os neoplasmas mais frequentemente observados, em ordem decrescente de frequência, foram: adenocarcinoma (9/50), carcinoma de células escamosas (9/50), tumor venéreo transmissível (5/50), osteossarcoma (5/50), condrossarcoma (4/50) e sarcoma indiferenciado (4/50). Com isso, pode-se estabelecer a frequência desses neoplasmas em 20 anos, bem como suas características clínicas, macroscópicas e histológicas.(AU)


Subject(s)
Animals , Dogs , Paranasal Sinuses/pathology , Paranasal Sinus Neoplasms/veterinary , Paranasal Sinus Neoplasms/epidemiology , Nose Neoplasms/pathology , Nose Neoplasms/veterinary , Nose Neoplasms/epidemiology , Dog Diseases/epidemiology , Nasal Cavity , Carcinoma/veterinary
10.
Rev. otorrinolaringol. cir. cabeza cuello ; 80(2): 209-217, jun. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1115837

ABSTRACT

El vestíbulo nasal corresponde a la primera porción de la fosa nasal, éste se encuentra delimitado lateralmente por los cartílagos alares y medialmente por el borde caudal del septum nasal y la columela. Las enfermedades infecciosas del vestíbulo nasal son patologías frecuentes en la práctica clínica; su diagnóstico se realiza en base a sospecha clínica y examen físico, requiriendo habitualmente solo manejo médico ambulatorio. Desde el punto de vista etiológico pueden ser virales, bacterianas y fúngicas. Las principales especies bacterianas involucradas corresponden a Staphylococcus coagulasa negativa, S. epidermidis, S. hominis y S. haemolyticus, difteroides spp y S. aureus. Su manejo es esencialmente médico con casos excepcionales requiriendo manejo quirúrgico. En la actualidad existe escasa información epidemiológica al respecto, lo que dificultad la clasificación de los dichos cuadros clínicos. Se realizó una revisión de la literatura sobre cuadros infecciosos que afectan el vestíbulo nasal para lograr sistematizar y clarificar las distintas patologías y sus tratamientos.


The nasal vestibule corresponds to the first portion of the nasal passage, limited laterally by the lateral crus and medially by the caudal edge of the nasal septum and columella. Infectious diseases of the nasal vestibule are frequent in clinical practice, diagnosis is made based on clinical suspicion and physical examination, usually requiring only ambulatory medical management. In terms of etiology, they can be viral, bacterial and fungal. The main bacterial species involved correspond: Coagulase-negative Staphylococcus, S. epidermidis, S. hominis and S. haemolyticus, difteroides spp and S. aureus. Management is essentially medical and only exceptionally requires surgery. Currently, there is a lack of epidemiological information in this regard, which makes it difficult to classify these clinical conditions. A review of the literature on infectious conditions that affect the nasal vestibule was performed, to systematize and clarify the different pathologies and their management.


Subject(s)
Humans , Bacterial Infections/complications , Nose Diseases/etiology , Nasal Cavity/microbiology , Papilloma/complications , Staphylococcus aureus , Staphylococcus epidermidis , Rhinoscleroma/complications , Nose Diseases/microbiology , Risk Factors , Staphylococcus haemolyticus , Staphylococcus hominis , Folliculitis/complications , Nasal Cavity/pathology
11.
Autops. Case Rep ; 10(2): e2020158, Apr.-June 2020. tab, graf
Article in English | LILACS | ID: biblio-1131814

ABSTRACT

Giant cell reparative granuloma (GCRG) was first described in the 1950s. It is an uncommon and benign reactive tumor that is believed to occur after trauma or inflammation. It most commonly occurs in the maxilla and mandible and rarely affects the nasal cavity. It is often seen in children and during the second to third decades of life, predominantly seen among females. Histopathologically, GCRG shows many osteoclast-like multinucleated giant cells scattered in a background of mononuclear stromal cells and spindle-shaped fibroblasts also associated with areas of hemorrhage. The distinction between GCRG and giant cell tumors (GCT)is crucial since both have a similar clinical and histological presentation, but both have different management. GCTs have malignant potential, may metastasize, and have a high rate of recurrence. Surgical excision is the mainstay therapy of GCRG to ensure a low rate of recurrence. Here we discuss two cases GCRG, both presenting as nasal mass.


Subject(s)
Humans , Female , Adolescent , Adult , Giant Cells , Granuloma/pathology , Nasal Cavity , Diagnosis, Differential , Giant Cell Tumors
12.
Dental press j. orthod. (Impr.) ; 25(3): 39-45, May-June 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1133667

ABSTRACT

ABSTRACT Introduction: Rapid maxillary expansion (RME) is assumed as a well established procedure; although, some effects on facial complex are not yet fully understood. Objective: The aim of this research was to verify, using cone-beam computed tomography, the effect on linear dimensions of the nasal cavity. Methods: Sample consisted of twenty patients aged 7 to 16 years, with skeletal deformity that justified the use of CT scans, and who required the RME as part of the orthodontic treatment planning. Scans were taken before clinical procedures were performed (T0) and after stabilizing the expander screw (T1). Dolphin Imaging v. 11.5 3D software was used to measure six areas on nasal cavity: three at the anterior portion (upper, middle, and lower) and other three at the posterior portion (also upper, middle, and lower). Data were statistically treated using Shapiro-Wilk test to verify normality. Differences between T0 and T1 were calculated using the Spearman correlation and paired Student's t-test, with a significance level of 5%. Results: All linear measurements presented a significant increase (p< 0.05) after RME, both in the anterior and posterior regions, suggesting some parallelism on the opening pattern, especially at the lower portion (p< 0.001). Conclusions: RME was able to significantly modify the internal dimensions of the nasal cavity.


RESUMO Introdução: A expansão rápida da maxila (ERM) é um procedimento bem estabelecido. Entretanto, alguns efeitos no complexo facial ainda não foram completamente compreendidos. Objetivo: O objetivo do presente estudo foi verificar o efeito da ERM nas medidas lineares da cavidade nasal, utilizando a tomografia computadorizada de feixe cônico (TCFC). Métodos: A amostra foi composta por 20 pacientes da Universidade Federal da Bahia, com idades entre 7 e 16 anos, com deformidades esqueléticas que justificavam o uso da TCFC e que necessitavam da ERM como parte do tratamento ortodôntico. As imagens tomográficas foram realizadas antes dos procedimentos clínicos (T0) e após estabilização do parafuso expansor (T1). O software Dolphin Imaging v. 11.5 3D (Dolphin, Chatsworth, CA, EUA) foi utilizado para mensurar seis áreas na cavidade nasal, três delas na região anterior (superior, média e inferior) e outras três na região posterior (também superior, média e inferior). Os dados foram trabalhados estatisticamente, utilizando o teste de Shapiro-Wilk para avaliar a normalidade. Diferenças entre T0 e T1 foram calculadas usando a Correlação de Spearman e o teste t de Student pareado, usando um nível de significância de 5%. Resultados: Todas as mensurações lineares apresentaram um aumento significativo (p< 0,05) após a ERM, tanto na região anterior quanto na posterior, sugerindo algum paralelismo no padrão de abertura, principalmente na porção inferior (p< 0,001). Conclusão: A ERM foi capaz de modificar significativamente as dimensões internas da cavidade nasal.


Subject(s)
Humans , Child , Adolescent , Palatal Expansion Technique , Nasal Cavity , Tomography, X-Ray Computed , Cone-Beam Computed Tomography , Maxilla
13.
Int. j. morphol ; 38(2): 444-447, abr. 2020. tab, graf
Article in English | LILACS | ID: biblio-1056460

ABSTRACT

This study was undertaken to determine the morphometry of the piriform aperture width and height in Turkish population aged between 18-60 years. It was a retrospective study in which 200 subjects were included 106 males and 94 females, ranging from 18 up to 60 years. Subjects having brain CT in the Radiology Department. Statistical analysis were evaluated with SPSS 21.00 programme. ANOVA Test were used to determine the significance between measurements and age group. The p<0.05 value was considered as significant. The groups were divided into four groups according to age. The overall means and standard deviations of the measurements were: piriform aperture height, 45.19±2.91 mm; piriform aperture width, 24.98±2.85 mm; the golden ratio, 1.84±0.19 in males, respectively whereas, the same measurements were 42.84±2.88; 23.46±2.15 mm; 1.83±0.19 in females, respectively. Also there were an increase in piriform aperture width measurement as the age increased. These anatomical values provides more important knowledge to determine the dimensions of these structures in clinic, surgical processes.


El estudio se realizó para determinar la morfometría del ancho y la altura de la abertura piriforme en la población turca de entre 18 y 60 años. Se llevó a cabo un análisis retrospectivo en el que se incluyeron 200 sujetos 106 hombres y 94 mujeres, entre los 18 y 60 años. Sujetos con TC cerebral en el Departamento de Radiología. El análisis estadístico se evaluó con el programa SPSS 21.00. La prueba ANOVA se utilizó para determinar la importancia entre las mediciones y el grupo de edad. El valor p <0,05 se consideró significativo. La muestra se dividió en cuatro grupos según la edad. Las medias generales y las desviaciones estándar de las mediciones fueron: altura de apertura piriforme, 45,19 ± 2,91 mm; ancho de apertura piriforme, 24,98 ± 2,85 mm; la proporción áurea, 1,84 ± 0,19 en varones, mientras que las mismas medidas fueron 42,84 ± 2,88; 23,46 ± 2,15 mm; 1,83 ± 0,19 en mujeres. También hubo un aumento en la medición del ancho de apertura piriforme a medida que la edad aumentó. Estos valores anatómicos proporcionan un conocimiento más importante para determinar las dimensiones de estas estructuras en procesos clínicos y quirúrgicos.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Nasal Cavity/diagnostic imaging , Turkey , Tomography, X-Ray Computed , Retrospective Studies , Analysis of Variance , Nasal Cavity/anatomy & histology
14.
Rev. otorrinolaringol. cir. cabeza cuello ; 80(1): 91-96, mar. 2020. graf
Article in Spanish | LILACS | ID: biblio-1099208

ABSTRACT

Los leiomiosarcomas de la cavidad nasal y senos paranasales son neoplasias malignas de baja frecuencia, localmente agresivas. Presentan una alta tendencia a la recurrencia de aproximadamente 55% en nariz y senos paranasales. Están conformados por células musculares lisas. Según diversos autores, aproximadamente el 50% de los pacientes mueren antes del primer año y la supervivencia a los 5 años es del 20%. Anteriormente se pensaba que no poseían potencial metastásico, sin embargo, en series actuales se ha visto que presentan un alto poder metastásico de hasta el 50%. Las metástasis se presentan de forma tardía. El tratamiento recomendado consiste en la resección radical del tumor primario con un amplio margen de tejido normal y la radioterapia es de uso controversial en el manejo.


Leiomyosarcoma of the nasal cavity and paranasal sinuses are malignant, low frequency, locally aggressive neoplasm. They present a high tendency to recurrence of approximately 55% in the nose and paranasal sinuses. They are made up of smooth muscle cells. According to different authors, approximately 50% of patients die before the first year and survival at 5 years is 20%. Previously it was thought that they did not possess metastatic potential, however in current series it has been seen that they have a high metastatic power of up to 50%. Metastases present late. The recommended treatment consists of radical resection of the primary tumor with a wide margin of normal tissue.


Subject(s)
Humans , Female , Middle Aged , Nose Neoplasms/surgery , Nose Neoplasms/diagnostic imaging , Leiomyosarcoma/surgery , Leiomyosarcoma/diagnostic imaging , Paranasal Sinuses , Magnetic Resonance Imaging , Nose Neoplasms/pathology , Endoscopy , Leiomyosarcoma/pathology , Nasal Cavity/surgery , Nasal Cavity/diagnostic imaging
15.
Braz. j. otorhinolaryngol. (Impr.) ; 86(1): 99-104, Jan.-Feb. 2020. tab
Article in English | LILACS | ID: biblio-1089377

ABSTRACT

Abstract Introduction Isotretinoin (13 cis-retinoic acid) is the most effective treatment for acne vulgaris and is the only treatment option that can provide either remission or a permanent cure. Objective The aim of this study was to use both subjective and objective methods to assess the nasal complaints of patients with severe acne who received oral isotretinoin therapy. Methods Fifty-four subjects were enrolled in the study. All the subjects were assessed with subjective (NOSE and VAS questionnaires) and objective (rhinomanometry and saccharine) tests to determine the severity of their nasal complaints. Results The mean severity scores (min: 0; max: 100) for nasal dryness/crusting and epistaxis were 0.47 ± 1.48 (0-5); 0.35 ± 1.30 (0-5) at admission, 3.57 ± 4.45 (0-10); 2.26 ± 4.71 (0-20) at the first month, and 4.28 ± 6 (0-20); 2.26 ± 4.71 (0-20) at the third month of the treatment respectively. Total nasal resistance of 0.195 ± 0.079 (0.12-0.56) Pa/cm3/s at admission, 0.21 ± 0.084 (0.12-0.54) Pa/cm3/s at the first month, and 0.216 ± 0.081 (0.14-0.54) Pa/cm3/s at the third month. Conclusion Oral isotretinoin therapy can cause the complaint of nasal obstruction. In addition, nasal complaints, such as dryness/crusting and epistaxis, significantly increase in patients during the therapy schedule.


Resumo Introdução A isotretinoína (ácido-13 cis-retinóico) é o tratamento por via oral mais eficaz para acne vulgar e é a única opção de tratamento que pode produzir remissão ou cura permanente. Objetivo Usar métodos subjetivos e objetivos para avaliar as queixas nasais de pacientes com acne grave que receberam terapia com isotretinoína oral. Método Foram incluídos no estudo 54 indivíduos. Todos os indivíduos foram avaliados por meio de testes subjetivos (questionários NOSE e escala EVA) e objetivos (rinomanometria e teste de sacarina) para determinar a gravidade de suas queixas nasais. Resultados Os escores médios de gravidade (min: 0; max: 100) para ressecamento/crostas e epistaxe nasal foram de 0,47 ± 1,48 (0-5); 0,35 ± 1,30 (0-5) no início, 3,57 ± 4,45 (0-10); 2,26 ± 4,71 (0-20) no primeiro mês e 4,28 ± 6 (0-20); 2,26 ± 4,71 (0-20) no terceiro mês do tratamento, respectivamente. A resistência nasal total foi de 0,195 ± 0,079 (0,12 a 0,56) Pa/cm3/s no início, 0,21 ± 0,084 (0,12 a 0,54) Pa/cm3/s no primeiro mês e 0,216 ± 0,081 (0,14 a 0,54) Pa/cm3/s no terceiro mês. Conclusão A terapia com isotretinoína por via oral pode resultar em queixa de obstrução nasal. Além disso, queixas nasais, tais como ressecamento/formação de crostas e epistaxe, aumentam significativamente nos pacientes durante o esquema terapêutico.


Subject(s)
Humans , Adolescent , Adult , Young Adult , Isotretinoin/pharmacology , Dermatologic Agents/pharmacology , Nasal Cavity/drug effects , Saccharin , Sweetening Agents , Severity of Illness Index , Isotretinoin/adverse effects , Isotretinoin/therapeutic use , Nasal Obstruction/diagnosis , Nasal Obstruction/etiology , Epistaxis/etiology , Prospective Studies , Surveys and Questionnaires , Acne Vulgaris/drug therapy , Rhinomanometry , Dermatologic Agents/adverse effects , Dermatologic Agents/therapeutic use , Symptom Assessment
16.
Article in Korean | WPRIM | ID: wpr-786595

ABSTRACT

Maxillectomy is performed to remove the tumor in the palate, maxillary sinus, buccal mucosa or nasal cavity. The resection range depends on the size and the extent of the tumor and it affects speech production or cause nasal regurgitation during feeding. Obturator can occlude an opening such as an oro-nasal fistula and protect the defect area. Successful reconstrucion of the patient's oral cavity who have gone over the maxillectomy is a difficult task. The condition and number of teeth, the remaining support area, and the extent of the defect area have a great influence on manufacturing the obturator. If these factors are disadvantageous, the prognosis of the prosthesis is uncertain. The final obturator must have a sufficient retention in the patient's oral cavity and must not irritate the surrounding tissue and support area where the resection was performed.In this case, a 55 year old female went through the maxillectomy and the only 3 teeth remained. And the retention of the maxillary prosthesis seems to be poor. So that, we fabricated the closed hollow obturator which has reduced weight compared to the conventional obturator. Consequently the closed hollow obturator can give better sealing and the adaptation.


Subject(s)
Female , Fistula , Humans , Maxillary Sinus , Maxillofacial Prosthesis , Mouth , Mouth Mucosa , Nasal Cavity , Palate , Palate, Hard , Prognosis , Prostheses and Implants , Tooth
17.
Annals of Dermatology ; : 155-158, 2020.
Article in English | WPRIM | ID: wpr-811081

ABSTRACT

Solitary fibrous tumors (SFT) are uncommon mesenchymal tumors. SFT have several synonyms including localized fibrous tumor, benign mesothelioma, localized fibrous mesothelioma, and submesothelial fibroma. SFT usually occur in the pleura or other serosal surfaces, but SFT can also develop in extrapleural areas including the nasal cavity, orbit, retroperitoneum, and pelvis. Cutaneous SFT is extremely rare, and more likely to occur in the head and neck region. Histologically, this tumor can mimic a variety of benign and malignant tumors such as dermatofibroma, dermatofibrosarcoma protuberans, spindle cell lipoma or other mesenchymal tumors. Most cases of SFT show non-aggressive clinical courses, with low recurrence rates. Herein, we describe a case of primary cutaneous SFT which presented with huge mass on the back.


Subject(s)
Dermatofibrosarcoma , Head , Histiocytoma, Benign Fibrous , Lipoma , Mesothelioma , Nasal Cavity , Neck , Orbit , Pelvis , Pleura , Recurrence , Skin , Solitary Fibrous Tumor, Pleural , Solitary Fibrous Tumors
18.
Article in Chinese | WPRIM | ID: wpr-826368

ABSTRACT

Nuclear protein of the testis midline carcinoma (NMC) is a rare malignant tumor that is mostly located in the upper trachea,mediastinal midline,and paravertebral midline,and few literature has described the imaging features of NMC in the nasal cavity and paranasal sinuses. In this article we summarize the clinical,radiologic,and pathologic data of one case of pathologically confirmed NMC in the nasal cavity and paranasal sinus by focusing on its CT and magnetic resonance imaging features.


Subject(s)
Humans , Magnetic Resonance Imaging , Nasal Cavity , Pathology , Nose Neoplasms , Diagnostic Imaging , Nuclear Proteins , Paranasal Sinus Neoplasms , Diagnostic Imaging , Paranasal Sinuses , Pathology , Tomography, X-Ray Computed
19.
São Paulo; s.n; s.n; 2020. 77 p. tab, graf.
Thesis in Portuguese | LILACS | ID: biblio-1292751

ABSTRACT

As primeiras células responsáveis pela percepção olfatória são os neurônios olfatórios (OSNs) presentes no epitélio olfatório (EO) da cavidade nasal, que reconhecem moléculas voláteis presentes no ar, denominadas odorantes, através de receptores específicos. Diferentemente de neurônios do sistema nervoso central (SNC), que estão relativamente protegidos de genotoxinas exógenas, OSNs estão em constante contato com agentes potencialmente genotóxicos, incluindo o oxigênio atmosférico. Além disto, em contraste com a maioria dos neurônios do SNC, OSNs são periodicamente repostos através de neurogênese adulta, portanto, possuem um tempo de vida menor do que outros neurônios. A função olfatória diminui durante o envelhecimento normal e patológico, através de mecanismos que ainda não estão totalmente claros. Em doenças neurodegenerativas, a perda do olfato é um dos sintomas iniciais e é utilizada como marcador de resposta a alguns tratamentos. Relações causais entre deficiências em reparo de DNA e neurodegeneração já foram demonstradas em vários modelos experimentais. No entanto, ainda não se sabe se alterações nessas vias contribuem para a perda olfatória observada nessas condições, provavelmente porque não há dados disponíveis na literatura sobre vias de reparo de DNA em OSNs. Por isso, o objetivo deste estudo foi caracterizar as vias de reparo de DNA presentes em populações de OSNs maduros e seus precursores. Analisamos dados de expressão de genes de reparo extraídos de dois transcriptomas diferentes, um relacionado à idade e outro, ao estágio de diferenciação destes neurônios. Em seguida, validamos os resultados obtidos da análise in silico através de PCR em tempo real utilizando amostras de EO de camundongos da linhagem C57BL/6J em duas idades (neonatos e com três semanas de idade). Nossos resultados indicam que OSNs são proficientes em todas as vias de reparo de excisão analisadas, apresentando expressão detectável de genes essenciais de cada via. A comparação entre populações enriquecidas em precursores ou em neurônios maduros, nas duas análises, sugere que a atividade de pelo menos quatro vias de reparo de excisão é menor em camundongos jovens, quando comparados aos neonatos, sugerindo, portanto, que há diminuição na expressão durante a diferenciação destas células. Esta observação vai corrobora com dados da literatura que mostraram que a expressão e atividade de proteínas de reparo em células proliferativas é maior do que em célulasterminalmente diferenciadas. Para testar a hipótese de que, por estarem em constante contato com agentes genotóxicos, OSNs acumulam mais lesões em DNA do que células no SNC, comparamos os níveis de lesões em DNA obtido de amostras de EO e de bulbo olfatório (BO), e de córtex temporal (CT), uma região cerebral que não apresenta taxas significativas de neurogênese e não expostas ao ambiente externo. A taxa de lesão foi calculada a partir de dados obtidos por PCR de longa extensão. Resultados obtidos utilizando EO, BO e CT de camundongos com três semanas de idade mostram que a amplificação em amostras de CT é muito menor do que em EO ou BO, sugerindo que neurônios do SNC acumulam mais lesões do que neurônios de regiões que apresentam neurogênese, mesmo que estas estejam constantemente expostas a agentes genotóxicos exógenos. Além disso, a eficiência de amplificação de fragmentos longos de DNA mitocondrial (mtDNA) foi menor em EO do que em BO, sugerindo que a constante exposição ao oxigênio atmosférico contribui para o acúmulo de lesões ao mtDNA, que é mais suscetível do que o DNA nuclear. Esse trabalho demonstra, pela primeira vez, que OSNs expressam proteínas essenciais de vias de reparo de DNA, cuja expressão decresce durante o processo de maturação dos neurônios olfatórios. Esses resultados devem contribuir para o entendimento dos mecanismos de manutenção da integridade genômica nestas células tão únicas


The first cells responsible for olfactory perception are the olfactory sensory neurons (OSNs), located in the olfactory epitelhium (OE) in the nasal cavity, which recognize volatile molecules in the air, called odorants, through olfactory receptors. Unlike neurons located in the central nervous system (CNS), which are relatively protected from exogenous toxins, OSNs are in constant contact with genotoxic agents, including atmospheric oxygen. Moreover, in contrast with most neurons in CNS, OSNs are periodically replaced through adult neurogenesis, therefore, having shorter lifespan than most neurons. Olfactory function decreases during normal and pathological aging, through mechanisms that are still not fully understood. In neurodegenerative diseases, olfactory loss is an early symptom and, in some cases, is used as a treatment response marker. DNA repair defects have been causally linked with neurodegeneration in different experimental models. However, it still unclear whether DNA repair alterations contribute to olfactory loss in these conditions, probably because there are no data available on DNA repair dynamic in OSNs. Therefore, our goal was to characterize the DNA repair pathways present in precursor and mature OSNs populations. We analyzed gene expression data from age-related and differentiation stage-related transcriptomes of these neurons, and validated the results by real time PCR using mouse OE samples from C57BL/6J lineage in two different ages (newborns and three weeks old). Our results indicate that OSNs are proficient in all DNA repair pathways investigated, showing detectable expression of essential genes from each pathway. When comparing populations enriched for mature OSNs or its precursors, our results suggest that the activities of at least four repair pathways are lower in young mice than in newborns, suggesting that DNA repair expression decreases during OSNs differentiation. This observation is consistent with published data showing that the expression and activities of repair proteins is lower in terminally differentiated than in proliferative cells . To test the hypothesis that OSNs would accumulate more DNA damage than CNS neurons, since they are in constant contact wtih genotoxic agents, we compared DNA damage levels in nuclear and mitochondrial DNA from OE, olfactory bulb (OB), and temporal cortex (TC) samples. We chose to use the TC region and a non-olfactory related control as it does not show significant adult neurogenesis and it is not exposed to external environment. Lesion rate wascalculated from data obtained by long extension PCR. Results from 3 weeks old mice OE, OB and TC samples showed that the amplification in TC samples is much lower than OE or OB samples, suggesting that neurons in CNS accumulate more damage than neurons that undergo neurogenesis. Besides, lesion frequency was higher in OE mitochondrial DNA (mtDNA) than in OB, suggesting that the constant exposure to atmospheric oxygen may contribute to accumulation of mtDNA lesions. This work demonstrates, for the first time, that OSNs are proficient in at least four DNA repair pathways, and that expression of key genes in these pathways decreases with differentiation. These results will contribute to better our understanding of the mechanisms involved in genomic stability in such unique cell types


Subject(s)
Olfactory Bulb , Smell , DNA Damage , DNA , Nasal Cavity , Computer Simulation , Central Nervous System , Receptors, Odorant , Neurodegenerative Diseases
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