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1.
Säo Paulo med. j ; 139(2): 147-155, Mar.-Apr. 2021. tab
Article in English | LILACS | ID: biblio-1290231

ABSTRACT

ABSTRACT BACKGROUND: The Health-Related Quality of Life Questionnaire for Nausea and Vomiting of Pregnancy (NVPQOL) is a validated questionnaire assessing quality of life among pregnant women with nausea and vomiting. OBJECTIVE: To translate, cross-culturally adapt and evaluate the reliability of the NVPQOL. DESIGN AND SETTING: Observational cross-sectional study developed in a public university in Brazil. METHODS: The translation, synthesis of translations, back-translation, expert committee, pre-testing and validation were carried out, resulting in a Portuguese-language version. The internal consistency, intra-rater and test-retest reliability and correlation between the total score of the Portuguese-language version of the NVPQOL and the domains of the World Health Organization Quality of Life-bref questionnaire were considered in the data analysis. RESULTS: The instrument went through the process with testing on 104 pregnant women. Strong internal consistency (Cronbach's α: 0.95), strong intra-rater and test-retest reliability (P < 0.0; intraclass correlation coefficient: 0.89; confidence interval: 0.791-0.945) and strong correlation between the total score of the Portuguese-language version of the NVPQOL and the physical health domain of the World Health Organization Quality of Life-bref questionnaire (P < 0.01; R = −0.8) were observed. CONCLUSION: The NVPQOL was translated, cross-culturally adapted and validated for the Portuguese language with satisfactory psychometric properties for assessing quality of life, especially in relation to physical health, among pregnant women with symptoms of nausea and vomiting in the first trimester of pregnancy.


Subject(s)
Humans , Female , Pregnancy , Quality of Life , Cross-Cultural Comparison , Psychometrics , Translations , Vomiting , Brazil , Cross-Sectional Studies , Surveys and Questionnaires , Reproducibility of Results , Nausea
2.
Infectio ; 25(1): 67-70, ene.-mar. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1154406

ABSTRACT

Resumen La infección por enterobacterias desencadena usualmente síntomas gastrointestinales caracterizados por vómito, diarrea y dolor abdominal, de severidad y curso variable. El compromiso extraintestinal esta descrito, inclusive sin las manifestaciones gastrointestinales clásicas lo que favorece diagnósticos y tratamientos tardíos pudiendo llegar a ser incapacitantes y letales. El síndrome de Ekiri, también denominado síndrome de encefalopatía letal tóxico, se caracteriza por una disfunción aguda del sistema nervioso central secundaria a infección por enterobacterias las cuales favorecen el desarrollo de microtrombos a nivel cerebral con inflamación mediada por el factor de necrosis tumoral α e IL- 1β y disfunción de la barrera hematoencefálica con una alta tasa de mortalidad. Dentro de nuestro conocimiento, presentamos el primer caso reportado en Colombia sobre el síndrome de Ekiri.


Abstract Gastrointestinal infection usually manifests with nausea, vomit and abdominal pain, all of them wit course and variable severity. Extrainstestinal compromise is described, even without gastrointestinal symptoms, what causes a delay on diagnosis and treatment, worsening the prognosis. Ekiri syndrome, also known as lethal toxic encephalopathy is characterized by an acute neurological dysfunction secondary to enterobacterial infection which favor thrombi development and local inflammation mediated by tumor necrosis factor alpha and IL-1β with blood brain barrier dysfunction and high mortality. As we know, we present the first Ekiri syndrome case reported in Colombia.


Subject(s)
Humans , Female , Adult , Brain Diseases , Syndrome , Neurotoxicity Syndromes , Diarrhea , Enterobacteriaceae Infections , Escherichia coli , Nausea
3.
Esc. Anna Nery Rev. Enferm ; 25(4): e20200520, 2021. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1279021

ABSTRACT

Resumo Objetivo identificar os principais sinais e sintomas manifestados por pacientes em cuidados paliativos oncológicos na assistência domiciliar. Método revisão integrativa nas bases LILACS, MEDLINE e CINAHL em janeiro de 2020. Perguntou-se: "Quais os principais sinais e sintomas manifestados por pacientes em cuidados paliativos oncológicos destacados nos estudos abrangendo o contexto do domicílio?". Foram descritores/termos: Sinais e Sintomas/Signs and Symptoms; Assistência Domiciliar/Home Care Services; Cuidados Paliativos/Palliative Care e Neoplasias/Neoplasms. Elencaram-se como critérios de elegibilidade: texto completo; entre 2015 e 2019; em inglês, português ou espanhol e idade adulta. Para o mapeamento dos dados, consideraram-se: título; país; ano; objetivo; método; sinais e sintomas. Os resultados foram categorizados em subgrupos, considerando a classificação conceitual predeterminada (sinal e sintoma). O elemento contagem facilitou a análise e a comparação de dados. Resultados foram selecionados 35 artigos, sendo identificados 25 sinais e 23 sintomas. Os mais frequentes foram: dor, náusea/vômito, dispneia, fadiga, depressão, ansiedade, constipação, perda de apetite, sonolência, bem-estar e insônia. A maioria (39) relacionou-se ao domínio físico. Conclusão a identificação dos principais sinais e sintomas, neste contexto, direciona a prática dos profissionais de saúde para as intervenções mais adequadas e o mais precocemente possível, contribuindo para viabilizar a assistência domiciliar, e alerta para a necessidade de educação permanente sobre este tema.


Resumen Objetivo identificar los principales signos y síntomas que manifiestan los pacientes en cuidados oncológicos paliativos en la atención domiciliaria. Método revisión integradora basada en LILACS, MEDLINE y CINAHL en enero de 2020. Se preguntó: "¿Cuáles son los principales signos y síntomas que manifiestan los pacientes en cuidados paliativos oncológicos destacados en estudios que abarcan el contexto del hogar?". Los descriptores / términos fueron: signos y síntomas / /Signs and Symptoms; Asistencia domiciliaria / Home Care Services; Cuidados paliativos / Palliative Care / y Neoplasias/ Neoplasms. Se enumeraron los siguientes criterios de elegibilidad: texto completo; entre 2015 y 2019; en inglés, portugués o español y edad adulta. Para el mapeo de datos, se consideraron los siguientes: título; padres; año; objetivo; método; signos y síntomas. Los resultados se categorizaron en subgrupos, considerando la clasificación conceptual predeterminada (signo y síntoma). El elemento de conteo facilitó el análisis y la comparación de datos. Resultados Se seleccionaron 35 artículos, se identificaron 25 signos y 23 síntomas. Los más frecuentes fueron: dolor, náuseas / vómitos, disnea, fatiga, depresión, ansiedad, estreñimiento, pérdida de apetito, somnolencia, bienestar e insomnio. La mayoría (39) estaban relacionados con el dominio físico. Conclusión la identificación de los principales signos y síntomas, en este contexto, orienta la práctica de los profesionales de la salud hacia las intervenciones más adecuadas y lo más temprano posible, contribuyendo a hacer factible la atención domiciliaria, y alerta sobre la necesidad de una educación permanente sobre este tema.


Abstract Objective to identify the main signs and symptoms manifested by palliative care oncology patients in home care. Method integrative review in LILACS, MEDLINE and CINAHL databases in January 2020. The question was asked: "What are the main signs and symptoms manifested by patients in palliative oncology care highlighted in studies covering the context of the home?" Descriptors/terms were: Signs and Symptoms/Signs and Symptoms; Home Care/Home Care Services; Palliative Care/Palliative Care and Neoplasms/Neoplasms. Eligibility criteria were listed as follows: full text; between 2015 and 2019; in English, Portuguese or Spanish and adult age. For data mapping, the following were considered: title; country; year; objective; method; signs and symptoms. The results were categorized into subgroups, considering the predetermined conceptual classification (sign and symptom). The counting element facilitated the analysis and comparison of data. Results a total of 35 articles were selected, and 25 signs and 23 symptoms were identified. The most frequent were: pain, nausea/vomiting, dyspnea, fatigue, depression, anxiety, constipation, loss of appetite, sleepiness, well-being, and insomnia. Most (39) were related to the physical domain. Conclusion the identification of the main signs and symptoms, in this context, directs the practice of health professionals to the most appropriate interventions as early as possible, contributing to the feasibility of home care, and alerts to the need for continuing education on this topic.


Subject(s)
Humans , Adult , Palliative Care , Death , Home Nursing , Neoplasms , Anxiety , Quality of Life , Anorexia , Constipation , Depression , Dyspnea , Fatigue , Cancer Pain , Sleepiness , Sleep Initiation and Maintenance Disorders , Nausea
5.
Arq. ciências saúde UNIPAR ; 24(1): 35-39, jan-abr. 2020.
Article in Portuguese | LILACS | ID: biblio-1095986

ABSTRACT

O câncer infanto-juvenil corresponde a um grupo de várias doenças que têm em comum a proliferação descontrolada de células anormais e que pode ocorrer em qualquer órgão em fase de desenvolvimento. Assim, o objetivo deste estudo foi descrever o perfil clínico e epidemiológico de crianças e adolescentes atendidos na UNACON durante o ano de 2017. Trata-se de um estudo descritivo, de corte transversal, desenvolvido a partir da análise de 20 prontuários de crianças e adolescentes com câncer. Foram coletados dados sobre as características sociodemográficas e clínicas-epidemiológicas dos pacientes. Os dados foram digitados, revisados e analisados no programa estatístico SPSS, na versão 21.0. Foram calculadas as frequências e a média das variáveis de interesse. Observou-se que a maioria dos pacientes tinha de um a três anos (45,0%), era do sexo masculino (60,0%), pardos (70,0%), com renda familiar de até um salário mínimo (60,0%) e metade procedia do interior do estado (50,0%), sendo o tipo de câncer mais diagnosticado a leucemia linfoide aguda (45,0%) e o principal tratamento utilizado a quimioterapia (95,0%), causando principalmente alopecia (100%), algia (100%), náuseas (65,0%), palidez (40,0%) e febre (25,0%) nos pacientes. Foi possível concluir que conhecer o perfil pode contribuir para a tomada de decisões da equipe gestora e profissionais de saúde da unidade no estabelecimento de medidas assistenciais aos pacientes, visando um atendimento mais humanizado, voltado para as necessidades sociodemográficas e levando em consideração as características clínicas-epidemiológicas desse grupo populacional.


Child and youth cancer corresponds to a group of several diseases that have in common the uncontrolled proliferation of abnormal cells and that can occur in any organ during the development phase. Thus, the purpose of this study was to describe the clinical and epidemiological profile of children and adolescents cared at UNACON during 2017. It is a descriptive, cross-sectional study developed from the analysis of 20 records of children and adolescents with cancer. Data on the sociodemographic and clinical-epidemiological characteristics of the patients were collected. The data were entered, reviewed and analyzed using the SPSS statistical program, version 21.0. The frequencies and the average of the variables of interest were calculated. It could be observed that the majority of patients were aged between one and three years (45.0%), male (60.0%), brown (70.0%), with a family income of up to one minimum wage (60.0%) and half (50.0%) came from the interior of the state, with acute lymphoid leukemia (45.0%) being the most frequent diagnosis, and chemotherapy (95.0%) the most frequent treatment used, causing mainly alopecia (100%), pain (100%), nausea (65.0%), pallor (40.0%) and fever (25.0%) in patients. It was possible to conclude that knowing the profile can contribute to the decision-making of the management team and health professionals at the health facility in the establishment of care measures for patients, aiming at a more humanized care, focused on sociodemographic needs and taking into account the clinical-epidemiological characteristics of this population group.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Health Profile , Neoplasms , Therapeutics , Leukemia/prevention & control , Medical Records , Diagnosis , Drug Therapy , Alopecia/drug therapy , Health Services Needs and Demand , Medical Oncology , Nausea/drug therapy
6.
Med. UIS ; 33(1): 31-38, ene.-abr. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1124983

ABSTRACT

Resumen Introducción: el modafinilo es un fármaco neuroestimulante utilizado principalmente para promover estados de vigilia atención y disminuir la fatiga ante ciertos comportamientos que propician la somnolencia diurna excesiva. Objetivo: identificar en la literatura científica los efectos adversos neurológicos y cardiovasculares causados por el consumo del modafinilo. Materiales y Métodos: revisión bibliográfica de los artículos encontrados entre los meses de abril y julio de 2019 en las bases de datos PUBMED, SCOPUS, DIALNET. 51 artículos superaron la evaluación de calidad metodológica y se incluyeron en la revisión. Resultados: se identificaron que los principales efectos adversos a nivel cardiovascular son la cardiomiopatía Tako-Tsubo y la taquicardia ventricular polimórfica, mientras que a nivel neurológico puede generar insomnio y distonías. Conclusiones: El consumo del modafinilo genera repercusiones en las funciones cognitivas y cardiovasculares por lo cual no es aconsejable su uso a largo plazo en personas sanas. MÉD. UIS.2020;33(1):31-8.


Abstract Introduction: modafinil is a neurostimulant drug used mainly to promote wakefulness, attention and decrease fatigue in certain behaviors that cause excessive daytime sleepiness. Objective: identify in the scientific literature the neurological and cardiovascular adverse effects caused by the consumption of modafinil. Materials and Methods: bibliographic review of the articles found between the months of April and July of 2019 in the PUBMED, SCOPUS, DIALNET databases. 51 articles passed the methodological quality assessment and were included in the review. Results: the main adverse effects at the cardiovascular level were identified as Tako-Tsubo cardiomyopathy and polymorphic ventricular tachycardia, while at the neurological level it can generate insomnia and dystonia. Conclusions: the consumption of modafinil generates repercussions on cognitive and cardiovascular functions, so its long-term use in healthy people is not advisable. MÉD.UIS.2020;33(1):31-8.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Sleep Wake Disorders , Tachycardia, Ventricular , Modafinil , Tachycardia , Blood Pressure , Dystonia , Takotsubo Cardiomyopathy , Headache , Central Nervous System Stimulants , Sleep Initiation and Maintenance Disorders , Narcolepsy , Nausea
7.
Arq. neuropsiquiatr ; 78(2): 121-123, Feb. 2020. graf
Article in English | LILACS | ID: biblio-1088997

ABSTRACT

ABSTRACT First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was associated with reports of syndromes characterized by uncontrollable nausea and vomiting related to structural damage in the area postrema, mainly in the context of demyelinating diseases. At the beginning of the 21st century, the so-called area postrema syndrome has been consolidated as a diagnostic factor in diseases related to the spectrum of neuromyelitis optica, more than 100 years after its first description.


RESUMO Descrita pela primeira vez por Retzius no final do século XIX, a estrutura na medula oblonga posterior, então nomeada de área postrema, passou por intensa investigação quanto à sua função nas décadas seguintes. Achados sobretudo em estudos com animais elucidaram parcialmente sua função como centro emético no sistema nervoso central. Na segunda metade do século XX, tal função foi associada a relatos de síndromes caracterizadas por náuseas e vômitos incoercíveis relacionadas a lesões estruturais na área postrema, principalmente no contexto das doenças desmielinizantes. Já no início do século XXI, a então chamada síndrome da área postrema se consolida como fator diagnóstico nas doenças relacionadas ao espectro da neuromielite óptica, mais de 100 anos sua primeira descrição.


Subject(s)
Humans , Neuromyelitis Optica , Area Postrema , Syndrome , Vomiting , Nausea
8.
Article in Korean | WPRIM | ID: wpr-811440

ABSTRACT

A 64-year-old man was treated with sunitinib as a first-line therapy for metastatic renal cell carcinoma. He was given oral sunitinib in cycles of 50 mg once daily for 2 weeks followed by a week off. During the 5th week of treatment right upper quadrant pain developed, but this resolved spontaneously during the 6th week (off treatment). However, on the 8th week of treatment, he was admitted to hospital because the acute right upper quadrant pain recurred with nausea, vomiting, and fever. Acute acalculous cholecystitis was then diagnosed by ultrasonography and CT. In addition, his laboratory findings indicated disseminated intravascular coagulation. Accordingly, sunitinib therapy was discontinued and broad-spectrum antibiotics initiated. He subsequently recovered after emergent percutaneous cholecystostomy. His Naranjo Adverse Drug Reaction Probability Scale score was 7, indicaing a probable association of the event with sunitinib. Suspicion of sunitinib-related acute cholecystitis is required, because, although uncommon, it can be life-threatening.


Subject(s)
Acalculous Cholecystitis , Anti-Bacterial Agents , Carcinoma, Renal Cell , Cholecystitis, Acute , Cholecystostomy , Disseminated Intravascular Coagulation , Drug-Related Side Effects and Adverse Reactions , Fever , Humans , Middle Aged , Nausea , Ultrasonography , Vomiting
9.
Article in Korean | WPRIM | ID: wpr-811332

ABSTRACT

PURPOSE: To report the clinical manifestations and computed tomography (CT) findings of patients with a trapdoor type medial orbital wall blowout fracture.METHODS: From March 2009 to October 2016, the clinical records and computed tomography findings of patients who underwent surgical treatment for a trapdoor type medial orbital wall blowout fracture were retrospectively analyzed.RESULTS: A total of eight patients (six males and two females) were enrolled with a combined mean age of 14.4 years. Clinical manifestations were eyeball movement limitation (abduction and adduction) and ocular motility pain (eight patients, 100%), diplopia (seven patients, 87.5%), and nausea and vomiting (four patients, 50%). On CT, the distance from the orbital apex to the fracture site was an average of 22.0 mm and occurred in the middle position of the entire wall. Two patients had missed rectus completely dislocated into the ethmoid sinus through the fracture gap and six patients had definite involvement in the fracture gap and edema of the medial rectus muscle. The medial rectus muscle cross-sectional area was 47.7 mm² which was edematous compared to the contralateral eye (40.1 mm²). Orbital wall reconstruction was performed an average of 4.1 days after the injury. In all patients with oculocardiac reflex-like nausea and vomiting immediately improved after surgery. Six out of eight patients who had eyeball movement limitations (abduction and adduction) preoperatively showed adduction limitation after surgery. The eyeball movement limitation and diplopia disappeared 11.7 days and 46.7 days after surgery, respectively.CONCLUSIONS: Patients with trapdoor type medial wall blowout fracture showed characteristic computed tomographic findings and clinical manifestations such as eyeball movement limitation, ocular motility pain, diplopia, and oculocardiac reflex. An understanding of clinical findings and quick surgical treatment are therefore required. The type of eyeball movement limitation was abduction and adduction limitation preoperatively and adduction limitation postoperatively.


Subject(s)
Diplopia , Edema , Ethmoid Sinus , Humans , Male , Nausea , Orbit , Reflex, Oculocardiac , Retrospective Studies , Vomiting
10.
Article in Korean | WPRIM | ID: wpr-811299

ABSTRACT

Many hospitals have patients perform preparative fasting prior to contrast-enhanced computed tomography to prevent nausea, vomiting, and accompanying aspiration pneumonia. This policy has been regarded as reasonable because there are many side effects such as vomiting when ionic high-osmolar contrast media are used. Recent advancements in contrast media development, side effects such as nausea and vomiting have markedly decreased. However, fasting prior to the contrast-enhanced computed tomography examination is still customary. While debatable, it is not clear that fasting prior to the use of contrast media has a beneficial effect on the prevention of vomiting. On the contrary, excessive fasting can cause patient dissatisfaction, dehydration, and exhaustion. Therefore, before using contrast media, the duration of fasting should be determined based on consideration of the risks, benefits, and patient’s comfort. In particular, to prevent dehydration, limitation of liquid intake during fasting is not recommended.


Subject(s)
Contrast Media , Dehydration , Fasting , Humans , Nausea , Pneumonia, Aspiration , Vomiting
11.
Article in English | WPRIM | ID: wpr-787233

ABSTRACT

Endobiliary radiofrequency ablation (RFA) is a procedure performed widely to induce locoregional tumor control by the transfer of thermal energy to the lesion and subsequent tumor necrosis. A 72-year-old male with a prior history of acute calculous cholangitis and perforated cholecystitis was admitted to the Kyungpook National University Hospital complaining of fever and nausea. He had an indwelling percutaneous transhepatic gallbladder drainage (PTGBD) catheter from the previous episode of perforated cholecystitis. An abdominal CT scan showed marked dilation of both the intrahepatic and extrahepatic bile ducts. Common bile duct cancer was confirmed histologically after an endobiliary biopsy. A surgical resection was considered to be the initial treatment option. During open surgery, multiple metastatic nodules were present in the small bowel mesentery and anterior abdominal wall. Resection of the tumor was not feasible, so endobiliary RFA was performed prior to biliary stenting. Cholecystectomy was required for the removal of the PTGBD catheter, but the surgical procedure could not be performed due to a cystic ductal invasion of the tumor. Instead, chemical ablation of the gallbladder (GB) with pure ethanol was performed to breakdown the GB mucosa. Palliative treatment for a biliary obstruction was achieved successfully using these procedures. In addition, a PTGBD catheter was removed successfully without significant side effects. As a result, an improvement in the patient's quality of life was accomplished.


Subject(s)
Abdominal Wall , Aged , Bile Ducts, Extrahepatic , Biopsy , Catheter Ablation , Catheters , Cholangiocarcinoma , Cholangiopancreatography, Endoscopic Retrograde , Cholangitis , Cholecystectomy , Cholecystitis , Common Bile Duct , Cystic Duct , Drainage , Ethanol , Fever , Gallbladder , Humans , Male , Mesentery , Mucous Membrane , Nausea , Necrosis , Palliative Care , Quality of Life , Stents , Tomography, X-Ray Computed
12.
Rev. Soc. Bras. Med. Trop ; 53: e20200714, 2020. tab, graf
Article in English | LILACS, ColecionaSUS, SES-SP | ID: biblio-1143864

ABSTRACT

Abstract INTRODUCTION: The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has greatly challenged public health worldwide. A growing number of studies have reported gastrointestinal (GI) symptoms. We performed a systematic review of GI symptoms associated with coronavirus disease 2019 (COVID-19) as well as of the serum levels of biomarkers related to liver function and lesion in SARS-CoV-2-infected individuals. METHODS: We surveyed relevant articles published in English, Spanish, and Portuguese up to July, 2020 in the PubMed, MEDLINE, SciELO, LILACS, and BVS databases. Moreover, we surveyed potentially important articles in journals such as the NEJM, JAMA, BMJ, Gut, and AJG. RESULTS: This systematic review included 43 studies, including 18,246 patients. Diarrhea was the most common GI symptom, affecting 11.5% of the patients, followed by nausea and vomiting (6.3%) and abdominal pain (2.3%). With regard to clinical severity, 17.5% of the patients were classified as severely ill, whereas 9.8% of them were considered to have a non-severe disease. Some studies showed increased aspartate transaminase and alanine aminotransferase levels in a portion of the 209 analyzed patients and two studies. CONCLUSIONS: Our results suggest that digestive symptoms are common in COVID-19 patients. In addition, alterations in cytolysis biomarkers could also be observed in a lesser proportion, calling attention to the possibility of hepatic involvement in SARS-CoV-2-infected individuals.


Subject(s)
Humans , Coronavirus Infections/pathology , Gastrointestinal Diseases/virology , Vomiting/virology , Abdominal Pain/virology , Diarrhea/virology , Pandemics , Nausea/virology
13.
Rev. saúde pública (Online) ; 54: 106, 2020. tab, graf
Article in English | LILACS, BBO, SES-SP | ID: biblio-1139472

ABSTRACT

ABSTRACT OBJECTIVE: To estimate the incidence and to evaluate risk factors for antineoplastic nausea and vomiting with high and moderate emetogenic chemotherapy in adult patients in the first treatment cycle. METHODS: Prospective cohort study with follow-up of 269 adults during the first cycle of antineoplastic chemotherapy. The incidence of nausea and vomiting was evaluated in the acute phase (0-24 hours), in the late phase (24 hours-5th day) and in the total phase (0-5th day). RESULTS: In total, 152 patients underwent high emetogenic chemotherapy and 117 moderate emetogenic chemotherapy. The relative frequency of nausea was higher when compared with vomiting in the acute phase (p < 0.001) and in the late phase (p < 0.001). The risk factors identified were: age group ≤ 49 years (odds ratio = 0.47; 95%CI 0.23-0.95) and 50-64 years (odds ratio = 0.45; 95%CI 0.23-0.87), tobacco use (odds ratio = 0.35; 95%CI 0.14-0.88), and high emetogenic chemotherapy (odds ratio 0.55; 95%CI 0.31-0.95). CONCLUSION: The incidence of nausea was higher than that of vomiting, and adverse effects were more frequent in the late phase. The results suggest the risk factors for chemotherapy-induced nausea and vomiting are tobacco, age (young adults), and high emetogenic chemotherapy.


RESUMO OBJETIVO: Estimar a incidência e avaliar os fatores de risco para náuseas e vômitos induzidos por antineoplásicos com alto e moderado potencial emético em pacientes adultos, no primeiro ciclo de tratamento. MÉTODOS: Estudo de coorte prospectiva, com 269 adultos acompanhados durante o primeiro ciclo de quimioterapia antineoplásica. A incidência de náuseas e vômitos foi avaliada na fase aguda (0-24 horas), na fase tardia (24 horas-5° dia) e na fase total (0-5° dia). RESULTADOS: 152 pacientes foram submetidos a quimioterápico com alto potencial emético e 117 a moderado potencial emético. A frequência relativa de náuseas foi maior quando comparada à de vômitos na fase aguda (p < 0,001) e na fase tardia (p < 0,001). Os fatores de risco identificados foram: faixa etária ≤ 49 anos (odds ratio = 0,47; IC95% 0,23-0,95) e 50-64 anos (odds ratio = 0,45; IC95% 0,23-0,87), uso de tabaco (odds ratio = 0,35; IC95% 0,14-0,88) e alto potencial emético dos quimioterápicos (odds ratio 0,55; IC95% 0,31-0,95). CONCLUSÃO: A incidência de náuseas foi maior do que a de vômitos, e na fase tardia os efeitos adversos foram mais frequentes. Os resultados sugerem que os fatores de risco para náuseas e vômitos induzidos por quimioterapia são o tabaco, a idade (adultos jovens) e o alto potencial emético do quimioterápico.


Subject(s)
Humans , Male , Female , Adult , Aged , Aged, 80 and over , Vomiting/chemically induced , Nausea/chemically induced , Neoplasms/drug therapy , Antineoplastic Agents/adverse effects , Vomiting/drug therapy , Vomiting/epidemiology , Brazil/epidemiology , Incidence , Prospective Studies , Risk Factors , Cohort Studies , Middle Aged , Antiemetics/therapeutic use , Nausea/drug therapy , Nausea/epidemiology , Antineoplastic Agents/therapeutic use
17.
Article in Chinese | WPRIM | ID: wpr-781778

ABSTRACT

OBJECTIVE@#To evaluate the clinical efficacy and partial action mechanism of mild moxibustion combined with salt-separated moxibustion for gastrointestinal discomfort caused by chemotherapy for breast cancer.@*METHODS@#A total of 48 patients were randomly divided into an observation group and a control group, 24 cases in each group. The patients in the control group were treated with intravenous infusion of tropisetron hydrochloride (5 mg), once a day for three days; the patients in the observation group were additionally treated with mild moxibustion at Zusanli (ST 36), Zhongwan (CV 12), Guanyuan (CV 4), Qihai (CV 6) and salt-separated moxibustion at Shenque (CV 8), 15 min per treatment, once a day for 7 days. Before treatment and on the 7th day of chemotherapy, the levels of pepsinogenⅠ(PGⅠ), pepsinogenⅡ (PGⅡ), the ratio of PGⅠto PGⅡ (PGR) and gastrin 17 (G-17) in serum were measured. Before treatment and on the 3rd, 5th, 7th day of chemotherapy, the gastrointestinal reactions (nausea, vomiting, constipation, diarrhea) were compared between the two groups.@*RESULTS@#On the 7th day of chemotherapy, the serum levels of PGⅠ, PGⅡand G-17 in the observation group were lower than those in the control group (0.05). The total scores of nausea, vomiting and constipation during chemotherapy in the observation group were significantly lower than those in the control group (all <0.05).@*CONCLUSION@#The mild moxibustion combined with salt-separated moxibustion could effectively improve the symptoms of nausea, vomiting and constipation caused by chemotherapy in patients with breast cancer, and its mechanism may be related to the down-regulation of the levels of PGⅠ, PGⅡ and G-17 in serum.


Subject(s)
Acupuncture Points , Breast Neoplasms , Therapeutics , Humans , Moxibustion , Nausea , Treatment Outcome
18.
Ciênc. cuid. saúde ; 19: e46652, 20200000.
Article in Portuguese | LILACS, BDENF | ID: biblio-1122057

ABSTRACT

Objectives: to identify the knowledge of oncological patients undergoing outpatient chemotherapy regarding emergency signs and symptoms.Methods: It is a descriptive, qualitative study. Two instruments were used: a questionnaire to characterize the participants and an open interview. The analysis of the first instrument was based on simple descriptive statistics; the second by thematic analysis. Results: The symptoms described by the participants were: fever, nausea, vomiting, constipation, inability/difficulty with food intake, headache, generalized pain or pain in places that refer to the tumor, dyspnea, vertigo, loss of consciousness, loss of ability to walk, chest pain and sudden changes in systemic pressure level (increase or decrease). As conditions that can interfere with the decision to seek emergency services, the manifestation of abnormal symptoms for the patient, the patient's knowledge about the pathology and treatment, as well as the patient's previous experience with the emergency service was identified.Conclusion: In short, the reasons that lead cancer patients to seek emergency are linked to the "severity" that it attributes to the effects of treatment.


Objetivo: identificar o conhecimento de pacientes oncológicos em tratamento quimioterápico ambulatorial sobre os sinais e sintomas de emergência. Métodos: Estudo descritivo, qualitativo. Utilizaram-se dois instrumentos: um questionário de caracterização dos participantes e uma entrevista aberta. A análise do primeiro instrumento foi por estatística descritiva simples; o segundo por análise temática. Resultados: Os sintomas descritos pelos participantes foram: febre, náuseas, vômitos, constipação, incapacidade/dificuldade de ingestão alimentar, cefaleia, dor generalizada ou dor nos locais que remetem ao tumor, dispneia, vertigem, perda de consciência, perda da capacidade de andar, dor no peito e variações bruscas de nível de pressão sistêmica (aumento ou diminuição).Como condições que podem interferir na decisão da busca pelo serviço de emergência, foi identificada a manifestação de sintomas anormais para o paciente, o conhecimento do paciente sobre a patologia e tratamento, além da experiência prévia do paciente com o serviço de emergência. Conclusão: Em suma, os motivos que levam o paciente oncológico a buscar a emergência estão ligados à "gravidade" que o mesmo atribui aos efeitos do tratamento.


Subject(s)
Humans , Male , Female , Signs and Symptoms , Drug Therapy , Emergencies , Patients , Vomiting , Constipation , Eating , Fever , Headache , Medical Oncology , Nausea , Neoplasms
19.
Rev. colomb. gastroenterol ; 34(2): 190-193, abr.-jun. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1013934

ABSTRACT

Resumen La enfermedad de Ménétrier, también conocida como gastritis hipertrófica gigante o gastropatía hipertrófica hipoproteinémica, es una entidad poco frecuente, caracterizada por una gastroenteropatía perdedora de proteínas, hipoclorhidria y engrosamiento de los pliegues mucosos del fondo y el cuerpo gástrico; es causante de un grupo clásico de síntomas que incluyen náuseas, vómitos, dolor abdominal y edema periférico; se asocia con un mayor riesgo de cáncer gástrico, sin embargo, su fisiopatología aún no está del todo esclarecida y su diagnóstico, clínico y endoscópico, puede llegar a ser difícil de establecer, por lo que se describe un caso clínico y se presenta una revisión sucinta de la literatura.


Abstract Menetrier disease (also known as giant hypertrophic gastritis or hypoproteinemic hypertrophic gastropathy) is a rare entity characterized by protein losing enteropathy, hypochlorhydria and thickening of the mucosal folds of the fundus and the gastric corpus. Its constellation of classic symptoms includes nausea, vomiting, abdominal pain and peripheral edema, and it is associated with increased risk of gastric cancer. Nevertheless, its pathophysiology is not yet fully understood and clinical and endoscopic diagnosis can be difficult to establish. This article describes a clinical case and provides a brief review of the literature.


Subject(s)
Humans , Male , Adult , Gastritis, Hypertrophic , Protein-Losing Enteropathies , Vomiting , Abdominal Pain , Nausea
20.
rev. cuid. (Bucaramanga. 2010) ; 10(1): e597, ene.-abr. 2019. tab
Article in Spanish | LILACS, BDENF, COLNAL | ID: biblio-1043560

ABSTRACT

Resumen Introducción Los síntomas de dolor y náusea vómito en los niños con cáncer son ocasionados por la enfermedad o tratamiento de quimioterapia. El manejo de estos síntomas es un reto en los familiares. Objetivos Describir y analizar la relación entre los síntomas de dolor y náusea vómito en los niños con cáncer y describir las estrategias de cuidado familiar ante estos síntomas. Materiales y Métodos Estudio descriptivo correlacional, con muestra de 31 niños y familiares de una clínica oncopediatrica de Veracruz México. Diligenciaron los instrumentos Escala de dolor con caras-Revisada, Clasificación de Náusea-Vómito Inducido por Quimioterapia y Cuestionario de estrategias de cuidado familiar para el manejo de síntomas. Los datos se analizaron con estadística descriptiva e inferencial con Rho de Spearman, utilizando el programa SPSS 20.0. Resultados Los niños padecen dolor moderado (48%), leve (29%) e intenso (23%). Tienen náusea-vómito agudo (74%), anticipatorio (16%) y retardado (10%). Existe asociación entre la náusea-vómito retardado con el anticipatorio (r =435<0,05). Los familiares contrarrestan el dolor del niño con estrategias de espiritualidad, distracción y fármacos. Ante la náusea-vómito evitan ambientes con olor a comida y consumo de líquidos calientes. Discusión: Según el tipo de cáncer y tratamiento, es la intensidad del dolor en el niño. La náusea-vómito se considera el síntoma más problemático durante la quimioterapia. Conclusiones La investigación aporta datos científicos para indagar a futuro estos síntomas y posibles secuelas físicas y psicológicas (depresión, ansiedad) en los niños con cáncer, así como la efectividad de las estrategias familiares para tratar estos síntomas.


Abstract Introduction Pain and nausea/vomiting symptoms in children with cancer are provoked by the disease or chemotherapy treatment. Managing these symptoms is a challenge for families. Purposes To describe and analyze the relationship of pain and nausea/vomiting symptoms in children with cancer and to describe the family care strategies for these symptoms. Materials and Methods A descriptive correlational study was conducted with a sample of 31 children and their families from an oncopediatric hospital in Veracruz, Mexico. Instruments such as Face pain scale - revised, chemotherapy-induced nausea-vomiting classification and questionnaire of family care strategies for symptom management were filled out. Data were analyzed using descriptive and inferential statistics using Spearman Rho correlation and SPSS 20.0 software. Results Children reported moderate pain in 48%, mild pain in 29% and severe pain in 23%. Acute nausea-vomiting was reported in 74%, anticipatory nausea-vomiting in 16% and delayed nausea-vomiting in 10%. There is an association between delayed nausea-vomiting and the anticipatory (r =435<0.05). Families alleviate pain in children using spiritual strategies, diversion and drugs. In the event of nausea and vomiting, they avoid food-related odor environments and hot beverage consumption. Discussion The intensity of pain in the child depends on the cancer type and treatment. Nausea-vomiting is considered the most troublesome symptom during chemotherapy. Conclusions Research brings scientific data to study these symptoms and future possible physical and psychological sequels (depression, anxiety, etc.) in children with cancer, as well as the effectiveness of family strategies to manage these symptoms.


Resumo Introdução Os sintomas de dor, náuseas e vómito em crianças com câncer são causados pela doença ou pelos tratamentos de quimioterapia. O manejo desses sintomas é um desafio para os familiares. Objetivos Descrever e analisar a relação entre os sintomas de dor, náuseas e vómito nas crianças com câncer e descrever as estratégias de cuidado familiar diante destes sintomas. Materiais e Métodos Estudo descritivo correlacional, com uma amostra de 31 crianças e familiares de uma clínica onco-pediátrica de Veracruz, México. Preencheram os instrumentos Escala de dor com caras - Revisada, Classificação de Náusea-Vómito Induzido por Quimioterapia e Questionário de estratégias de cuidado familiar para o manejo dos sintomas. Os dados foram analisados com estatística descritiva e inferencial com Rho de Spearman, utilizando o programa SPSS 20.0. Resultados As crianças sofrem dor moderada (48%), leve (29%) e intensa (23%). Sentem náusea-vómito agudo (74%), antecipatório (16%) e retardado (10%). Existe associação entre a náusea-vómito retardado com o antecipatório (r =435<0,05). Os familiares combatem a dor da criança com estratégias de espiritualidade, distração e fármacos. Diante da náusea-vómito evitam ambientes com cheiro a comida e a ingesta de líquidos quentes. Discussão: O tipo de câncer e tratamento determina a intensidade da dor na criança. A náusea-vómito é considerado o sintoma mais problemático durante a quimioterapia. Conclusões A pesquisa fornece dados científicos para indagar sobre estes sintomas e as possíveis sequelas físicas e psicológicas no futuro (depressão, ansiedade) nas crianças com câncer, bem como a efetividade das estratégias familiares para o tratamento desses sintomas.


Subject(s)
Humans , Male , Female , Vomiting , Family , Nausea , Child , Cancer Pain
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