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Acta cir. bras ; 34(12): e201901207, 2019. graf
Article in English | LILACS | ID: biblio-1054689


Abstract In the muscle invasive bladder cancer (MIBC) standard of care treatment only patients presenting a major pathological tumor response are more likely to show the established modest 5% absolute survival benefit at 5 years after cisplatin-based neoadjuvant chemotherapy (NAC). To overcome the drawbacks of a blind NAC (i.e. late cystectomy with unnecessary NAC adverse events) with potential to survival improvements, preclinical models of urothelial carcinoma have arisen in this generation as a way to pre-determine drug resistance even before therapy is targeted. The implantation of tumor specimens in the chorioallantoic membrane (MCA) of the chicken embryo results in a high-efficiency graft, thus allowing large-scale studies of patient-derived "tumor avatar". This article discusses a novel approach that exploits cancer multidrug resistance to provide personalized phenotype-based therapy utilizing the MIBC NAC dilemma.

Humans , Animals , Urinary Bladder Neoplasms/drug therapy , Carcinoma/drug therapy , Urothelium/pathology , Chorioallantoic Membrane/pathology , Neoplasms, Experimental/drug therapy , Phenotype , Urinary Bladder Neoplasms/pathology , Carcinoma/pathology , Neoadjuvant Therapy , Medical Illustration , Neoplasm Seeding , Neoplasms, Experimental/pathology
Article in English | WPRIM | ID: wpr-741442


OBJECTIVE: To evaluate the impact of energy and access methods on extrahepatic tumor spreading and the ablation zone in an ex vivo subcapsular tumor mimic model with a risk of extrahepatic tumor spreading. MATERIALS AND METHODS: Forty-two tumor-mimics were created in bovine liver blocks by injecting a mixture of iodine contrast material just below the liver capsule. Radiofrequency (RF) ablations were performed using an electrode placed parallel or perpendicular to hepatic surface through the tumor mimic with low- and high-power protocols (groups 1 and 2, respectively). Computed tomography (CT) scans were performed before and after ablation. The presence of contrast leak on the hepatic surface on CT, size of ablation zone, and timing of the first roll-off and popping sound were compared between the groups. RESULTS: With parallel access, one contrast leak in group 1 (1/10, 10%) and nine in group 2 (9/10, 90%) (p < 0.001) were identified on post-ablation CT. With perpendicular access, six contrast leaks were identified in each group (6/11, 54.5%). The first roll-off and popping sound were significantly delayed in group 1 irrespective of the access method (p = 0.002). No statistical difference in the size of the ablation zone of the liver specimen was observed between the two groups (p = 0.247). CONCLUSION: Low-power RF ablation with parallel access is proposed to be effective and safe from extrahepatic tumor spreading in RF ablation of a solid hepatic tumor in the subcapsular location. Perpendicular placement of an electrode to the capsule is associated with a risk of extrahepatic tumor spreading regardless of the power applied.

Animals , Catheter Ablation , Electrodes , Iodine , Liver , Liver Neoplasms, Experimental , Methods , Neoplasm Seeding
Article in English | WPRIM | ID: wpr-714691


OBJECTIVE: The aim of the study is to investigate recurrence of stage I epithelial ovarian cancer. METHODS: Six hundred two patients diagnosed with stage I epithelial ovarian cancer at 4 hospitals between 2000 and 2013 were retrospectively analyzed. Age, surgical procedure, substage, histologic type, adjuvant chemotherapy, recurrence, initial recurrence site (peritoneal dissemination [P], hematogenous recurrence [H], lymphogenous recurrence [L], and others [O]), and frequency of recurrence at each site were investigated retrospectively. RESULTS: Median age was 54 years and median follow-up was 60 months. The stage was IA in 180 cases (30%), IB in 8 (1%), IC1 in 247 (41%), IC2 in 63 (10%), and IC3 in 104 (17%). Systematic lymph node dissection including both pelvic and para-aortic lymph nodes was performed in 224 patients (37%), and 412 patients (68%) received adjuvant chemotherapy. Recurrence occurred in 70 patients (11.6%). The median time to recurrence was 18 months, and the stage was IA in 13 (19%), IB in 1 (1%), IC1 in 24 (34%), IC2 in 9 (13%), and IC3 in 23 (33%) cases. The numbers of recurrence at the P, H, L, and O sites, including overlapping cases, were 49 (70%), 18 (26%), 9 (13%), and 6 (9%), respectively, and recurrence by peritoneal dissemination in the pelvis occurred in 43 cases (61%). CONCLUSION: Recurrence of stage I epithelial ovarian cancer by peritoneal dissemination was frequent, especially in the pelvis. There is a need to elucidate the pathogenesis of peritoneal recurrence and to prepare a treatment strategy to prevent pelvic peritoneal recurrence.

Chemotherapy, Adjuvant , Follow-Up Studies , Humans , Lymph Node Excision , Lymph Nodes , Neoplasm Metastasis , Neoplasm Seeding , Ovarian Neoplasms , Pelvis , Recurrence , Retrospective Studies
Article in English | WPRIM | ID: wpr-740141


Intraperitoneal metastatic hepatocellular carcinoma (HCC) is uncommon. Although rare, it can spontaneously rupture and cause hemoperitoneum similar to primary HCC in the liver. We present a case of intraperitoneal metastatic HCC that had spontaneously ruptured and appeared as an irregularly margined hemorrhagic mass with T1 high and T2 dark signal intensities on magnetic resonance imaging. Ruptured HCC is a life-threatening emergency with high mortality rate. Spontaneously ruptured intraperitoneal metastatic HCC should be considered if a patient with a history of HCC presents with acute abdomen, although rare.

Abdomen, Acute , Carcinoma, Hepatocellular , Emergencies , Hemoperitoneum , Humans , Liver , Magnetic Resonance Imaging , Mortality , Neoplasm Seeding , Rupture , Rupture, Spontaneous
Kosin Medical Journal ; : 251-257, 2017.
Article in English | WPRIM | ID: wpr-60694


Radiofrequency ablation (RFA), a local ablative modality, is gaining acceptance for the treatment of liver malignancies. Despite a relatively low complication rate, tumor seeding resulting from RFA in hepatocellular carcinoma (HCC) treatment can occur. A 44-year-old woman was diagnosed with HCC. Spiral computed tomography (CT) revealed a 2.3 × 2.0-cm mass in the S5 segment, which was treated with RFA on May, 2005. Follow-up imaging, performed at 6-month intervals after RFA, showed complete tumor necrosis. In October 2009, CT revealed a heterogeneous mass, 5.7 cm in diameter, in the right ovary. Since the lesion was limited to the right ovary without evidence of spread, bilateral salpingo-oophorectomy was performed. Histopathology indicated that the metastatic spread from the HCC to the ovary was positive for hepatocyte-specific antigen on immunohistochemistry. The ovary is a rare site for HCC metastasis. Moreover, needle tract implantation of HCC in the ovary is very rare.

Adult , Carcinoma, Hepatocellular , Catheter Ablation , Female , Follow-Up Studies , Humans , Immunohistochemistry , Liver , Necrosis , Needles , Neoplasm Metastasis , Neoplasm Seeding , Ovary , Tomography, Spiral Computed
Basic and Clinical Neuroscience. 2016; 7 (2): 159-164
in English | IMEMR | ID: emr-178794


Introduction: Meningioma is a benign and slowly-growing tumor that is responsible for 20% of brain neoplasms. It can be accompanied by some genetic disorders such as neurofibromatosis type 2 and is more common among women. As a space occupying lesion, it produces a wide range of signs and symptoms by compressing the adjacent and underlying tissues in the brain. Trauma and viruses are possible etiologies for meningioma. The ideal treatment of benign meningioma is surgical resection

Case Presentation: In this case report, we present a middle-aged man with a seeding metastasis of the cranial meningioma [after its removal] in the left thigh. During the removal operation, fascia lata had been used to repair the dura mater and the skin defect was repaired primarily

Conclusion: We believe that the occurrence of meningioma at the site of incision in the thigh is related to using the same surgical instruments for the removal of the brain tumor

Humans , Male , Middle Aged , Meningeal Neoplasms , Neoplasm Seeding , Thigh
Korean Journal of Urology ; : 666-669, 2015.
Article in English | WPRIM | ID: wpr-47845


A 66-year-old man underwent computed tomography-guided needle biopsy of a suspicious renal mass. Two months later he underwent partial nephrectomy. Histology revealed a 30-mm clear cell renal cell carcinoma, up to Fuhrman grade 3. An area of the capsule was interrupted, which corresponded to a hemorrhagic area on the cortical surface. Under microscopy, this area showed a tongue of tumor tissue protruding through the renal capsule. A tumor deposit was found in the perinephric fat. These features suggest that tumor seeding may have occurred during the needle biopsy.

Adipose Tissue/pathology , Aged , Biopsy, Needle/adverse effects , Carcinoma, Renal Cell/secondary , Humans , Image-Guided Biopsy/adverse effects , Kidney/pathology , Kidney Neoplasms/pathology , Male , Neoplasm Seeding , Soft Tissue Neoplasms/secondary
Article in Chinese | WPRIM | ID: wpr-357166


<p><b>OBJECTIVE</b>To explore the exfoliated cancer cell contamination in different surgical materials during the malignant gastrectomy.</p><p><b>METHODS</b>Ninety gastric cancer patients undergoing gastrectomy were prospectively enrolled in this study. The operation materials of these 90 gastrectomy were divided into 5 groups: surgical instruments (A), gloves for surgeons (B), gloves and gauzes of scrub nurse (C), gauzes for hemostasis (D), anastomosis instrument (E). The rinse fluid of materials was cultured to verify positive cancer cells. Associations among different pathological stages, differentiations, materials and positive cancer cells rates were examined.</p><p><b>RESULTS</b>Stage II and III patients had higher positive rates of exfoliated cancer cell contamination than stage I patients [26.5 (9/34) and 47.5% (21/46) vs. 10.0% (1/10),P=0.046]. Low differentiated adenocarcinoma group had higher positive rate than moderately and well differentiated adenocarcinoma groups [44.8% (26/58) vs. 16.7% (4/24) and 12.5% (1/8), P=0.020]. Positive cancer cell rates of 5 kinds of materials were as follows: 12.2% (11/90) in A group, 6.7% (6/90) in B group, 22.2% (20/90) in C group, 15.6% (14/90) in D group and 3.3% (3/90) in E group, and the differences were significant (P<0.01).</p><p><b>CONCLUSION</b>Different operation materials have different risks to be contaminated by cancer cells, which is associated with the contact frequency, cancer staging and pathological classification.</p>

Adult , Aged , Equipment Contamination , Female , Gastrectomy , Humans , Male , Middle Aged , Neoplasm Seeding , Prospective Studies , Stomach Neoplasms , Pathology , General Surgery , Surgical Equipment
Article in Chinese | WPRIM | ID: wpr-314785


<p><b>OBJECTIVE</b>To study the effect of enteral nutrition as replacement of mechanical bowel preparation on peritoneal and intraluminal disseminated tumor cells, recurrence and metastasis in patients with colorectal cancer.</p><p><b>METHODS</b>A total of 120 colorectal cancer patients between March 2007 and December 2011 were enrolled prospectively and randomly divided into two groups. Group A (n=60) received preoperative bowel preparation with enteral nutrition fluid (30 ml·kg(-1)·d(-1)), without enema, taxative or antibiotics. Group B (n=60) underwent traditional intestinal preparation consecutively 3 days before operation, including fasting, oral antibiotic, and cleaning enema. All the patients received peritoneal lavage with 400 ml of normal saline at the time of laparotomy and 200 ml of the lavage fluid was collected. All the cases underwent distal colorectal lavage with 1000 ml of normal saline before anastomosis, and 500 ml of the lavage fluid was collected. Fluid samples were quickly sent for exfoliated cytological examination. The positive rates of exfoliated cancer cell in peritoneal cavity and intraluminal cavity, postoperative complication, recurrence and metastasis were compared between the two groups.</p><p><b>RESULTS</b>In group A, exfoliated cancer cells were found in 5 of 60 cases (8.3%) in peritoneal lavage fluid and in 9 of 60 cases (15.0%) in distal colorectal lavage fluid, while in group B, cancer cells were found in 13 of 60 cases (12.5%) and 19 of 60 cases (31.7%) respectively. There were significant differences between group A and B (P=0.041, P=0.031). Fifty-five patients in group A were followed up from 16 to 46 months after surgery, as well 57 patients in group B. Rates of local recurrence and distant metastasis in Group A and B were 5.5% vs. 7.0% and 10.9% vs. 10.5% respectively. There were no significant differences (P=0.733, P=0.984). There was no significant difference in 3-year survival rate between the two groups (80% vs. 78%, P=0.312).</p><p><b>CONCLUSIONS</b>Enteral nutrition instead of traditional bowel preparation can decrease the positive rate of disseminated cancer cells in peritoneal cavity or colorectal lumen, while dose not affect recurrence and metastasis rates in patients with colorectal cancer.</p>

Aged , Colorectal Neoplasms , Pathology , General Surgery , Enteral Nutrition , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Neoplasm Seeding , Preoperative Care
Rev. bras. ortop ; 47(5): 631-637, set.-out. 2012.
Article in Portuguese | LILACS | ID: lil-660915


OBJETIVO: Estudar os fatores possivelmente associados à contaminação tumoral do trajeto de biópsia de tumores ósseos malignos primários. MÉTODO: Foram estudados, retrospectivamente, 35 pacientes submetidos a tratamento cirúrgico com diagnóstico de osteossarcoma, tumor de Ewing e condrossarcoma. A amostra foi analisada para caracterização quanto à técnica de biópsia empregada, tipo histológico do tumor, realização de quimioterapia neoadjuvante, ocorrência de recidiva local e contaminação tumoral no trajeto da biópsia. RESULTADOS: Nos 35 pacientes avaliados ocorreram quatro contaminações (11,43%). Um caso era de osteossarcoma, dois casos de tumor de Ewing e um caso de condrossarcoma, não se observando associação entre o tipo de tumor e a presença de contaminação tumoral no trajeto da biópsia (p = 0,65). Também não se observou associação entre a presença de contaminação tumoral e a técnica de biópsia (p = 0,06). Por outro lado, observou-se associação entre a presença de contaminação tumoral e a ocorrência de recidiva local (p = 0,01) e entre a presença de contaminação e a não realização de quimioterapia neoadjuvante (p = 0,02). CONCLUSÃO: A contaminação tumoral no trajeto de biópsia de tumores ósseos malignos primários esteve associada à ocorrência de recidiva local. Por outro lado, não mostrou ser influenciada pelo tipo de biópsia realizada e pelo tipo histológico de tumor estudado. A quimioterapia neoadjuvante mostrou um efeito protetor contra esta complicação. A despeito desses achados, a contaminação tumoral é uma complicação que deve sempre ser considerada, sendo recomendada a remoção do trajeto da biópsia na cirurgia de ressecção do tumor.

OBJECTIVE: To study factors possibly associated with tumor contamination in the biopsy path of primary malignant bone tumors. METHOD: Thirty-five patients who underwent surgical treatment with diagnoses of osteosarcoma, Ewing's tumor and chondrosarcoma were studied retrospectively. The sample was analyzed to characterize the biopsy technique used, histological type of the tumor, neoadjuvant chemotherapy used, local recurrences and tumor contamination in the biopsy path. RESULTS: Among the 35 patients studied, four cases of contamination occurred (11.43%): one from osteosarcoma, two from Ewing's tumor and one from chondrosarcoma. There was no association between the type of tumor and presence of tumor contamination in the biopsy path (p = 0.65). There was also no association between the presence of tumor contamination and the biopsy technique (p = 0.06). On the other hand, there were associations between the presence of tumor contamination and local recurrence (p = 0.01) and between tumor contamination and absence of neoadjuvant chemotherapy (p = 0.02). CONCLUSION: Tumor contamination in the biopsy path of primary malignant bone tumors was associated with local recurrence. On the other hand, the histological type of the tumor and the type of biopsy did not have an influence on tumor contamination. Neoadjuvant chemotherapy had a protective effect against this complication. Despite these findings, tumor contamination is a complication that should always be taken into consideration, and removal of the biopsy path is recommended in tumor resection surgery.

Humans , Male , Female , Child , Adolescent , Young Adult , Middle Aged , Aged, 80 and over , Biopsy , Bone Neoplasms , Neoplasm Recurrence, Local , Neoplasm Seeding , Sarcoma , Musculoskeletal System/pathology
Chinese Journal of Oncology ; (12): 945-949, 2012.
Article in Chinese | WPRIM | ID: wpr-284252


<p><b>OBJECTIVE</b>To analyze the major complications of percutaneous cooled-tip microwave ablation for the treatment of primary liver cancer and the possible risk factors of severe complications in a series of 693 patients.</p><p><b>METHODS</b>The clinicopathological data of 693 patients with primary liver cancer who underwent ultrasound-guided percutaneous cooled-tip microwave (MW) ablation in our hospital over the past 5 years were retrospectively analyzed, and the risk factors of severe complications were explored.</p><p><b>RESULTS</b>In a total of 693 patients with 898 primary liver tumors were treated and 1111 MW ablation sessions were performed. The mean diameter of tumors was (2.5 ± 1.2) cm and the range was 0.4 - 10.0 cm. Three deaths occurred in the peri-ablation period, including one case died of multiorgan failure, one case died of pulmonary embolism and one case died of hepatorenal syndrome. Major complications occurred in 27 (3.9%) patients, including 12 pleural effusion requiring thoracentesis (1.7%), 10 tumor seeding (1.4%), 3 liver abscess and empyema (0.4%), 1 hemorrhage requiring arterial embolization (0.1%), and 1 bile duct injury (0.1%). The Chi-square test results showed that the diameter of tumors, number of MW ablation sessions and histological type of tumor were significantly associated with the major complications rate (P < 0.05). The multiple variables 1ogistic regression analysis showed that only type of tumors was associated with the major complication rate (P < 0.05).</p><p><b>CONCLUSIONS</b>Results of this study confirm that cooled-tip MW ablation is a relatively low-risk and effective minimally invasive procedure for the treatment of primary liver cancer. Proper direction for the treatment of cholangiocarcinoma (ICC) patients as well as fewer ablated tumor numbers during one hospital stay may help minimize the major complication rate in patients with primary liver cancer treated by ultrasound-guided percutaneous cooled-tip microwave ablation.</p>

Adult , Aged , Aged, 80 and over , Bile Duct Neoplasms , Diagnostic Imaging , General Surgery , Bile Ducts, Intrahepatic , Carcinoma, Hepatocellular , Diagnostic Imaging , General Surgery , Catheter Ablation , Methods , Cholangiocarcinoma , Diagnostic Imaging , General Surgery , Female , Follow-Up Studies , Humans , Liver Abscess , Drug Therapy , Liver Neoplasms , Diagnostic Imaging , General Surgery , Male , Microwaves , Therapeutic Uses , Middle Aged , Neoplasm Seeding , Pleural Effusion , General Surgery , Retrospective Studies , Ultrasonography, Interventional
Rev. bras. cir. plást ; 26(1): 151-159, jan.-mar. 2011. ilus, tab
Article in Portuguese | LILACS | ID: lil-589123


INTRODUÇÃO: A recente descoberta que tecidos adultos têm células-tronco com capacidade pluripotencial deu início a uma série de pesquisas, pois descarta questões ético-religiosas e imunológicas. A Cirurgia Plástica despertou interesse recentemente para o tema, e participa nas pesquisas de células-tronco a partir do momento que o tecido adiposo e a pele tornaram-se fontes de obtenção e diferenciação de células-tronco, abrindo novas perspectivas de tratamento para deformidades congênitas e adquiridas, com finalidade reparadora ou estética. OBJETIVO: Mostrar o estágio atual das pesquisas publicadas com células-tronco adultas ou somáticas, com ênfase nas derivadas da gordura e da pele, e as perspectivas de terapia celular com células-tronco que mostrem relação com a Cirurgia Plástica. MÉTODO: Utilizamos o sistema Medline, via website da Biblioteca Virtual em Saúde (, pesquisando artigos no período de 1997-2009, o sistema LILACS pelo mesmo endereço eletrônico e no mesmo período e, por último, o programa de busca Google, para o mesmo período ( RESULTADOS E CONCLUSÕES: Os estudos recentes publicados sobre células-tronco relacionados à Cirurgia Plástica demonstram novas perspectivas para correção de deformidades adquiridas e congênitas, alterações cicatriciais, queimaduras, estrias, manchas hiper e hipocrômicas, bem como participação na obtenção e no preparo de material (gordura e pele) para uso em outras especialidades médicas. Os estudos se multiplicam em todo o mundo, e é importante que a especialidade Cirurgia Plástica esteja envolvida e atenta a esta promissora área de pesquisa e tratamento.

INTRODUCTION: The fact that adult tissues have stem cells with pluripotential capacity starts a new wave of research, especially because it dismisses immunologic problems and ethic and religious questions. Plastic Surgery arouses interest recently and participates in stem cell researches since the adipose tissue and skin became sources of stem cells both for acquisition and differentiation. It opens new perspectives for congenital and acquired deformities with esthetic and reconstructive purpose. OBJECTIVE: To show actual stage of adult and somatic stem cell published researches, especially stem cell derived from fat and skin and the perspectives of cellular therapy for Plastic Surgery. METHODS: We use Medline system (, searching articles between 1997 and 2009, LILACS system by the same electronic address and period, at last, the search engine Google ( for the same period. RESULTS AND CONCLUSIONS: Recent published studies of stem cells related with Plastic Surgery show new perspectives for correction of acquired and congenital deformities, scar alterations, burns, stria, hiper and hipocromic spots and partnership with obtention and prepare of fat and skin to be used in other medical specialties. Studies are multiplying around the world and is very important that Plastic Surgery be engaged and attentive to this promising area of research and treatment.

Humans , Adipose Tissue , Fibroblasts , Neoplasm Seeding , Neoplasms , Stem Cells , Surgery, Plastic , Surgical Procedures, Operative , Tissue Engineering , Diagnostic Techniques and Procedures , Methods , Patients , Retrospective Studies
Article in English | WPRIM | ID: wpr-172644


BACKGROUND/AIMS: Needle-track seeding is a rare but important complication of diagnostic and therapeutic ultrasound (US)-guided procedures in hepatocellular carcinoma (HCC). We examined the frequency of needle-track seeding after US-guided percutaneous ethanol injection (PEI), fine-needle aspiration biopsy (FNAB), and percutaneous transhepatic biliary drainage (PTBD) in order to determine the appropriate treatment for needle-track seeding and its clinical outcome. METHODS: We analyzed the clinical characteristics and treatment outcomes in eight patients who experienced needle-track seeding from HCC after an US-guided procedure (FNAB, PEI, or PTBD) between January 1990 and July 2004. RESULTS: Seven (0.14%) of 5,092 patients who experienced needle-track seeding (2 after PEI, 4 after FNAB, and 1 after PTBD) during the study period and 1 other patient who experienced needle-track seeding recently were recruited for this study. Two of the eight patients underwent mass excision and the other six patients underwent en-bloc wide excision for the needle-track seeding. Tumors recurred in the needle-tracks in both patients who underwent mass excision but not in the six patients who underwent en-bloc wide excision. Mortality occurred in three patients who experienced the recurrence and progression of intrahepatic HCC. CONCLUSIONS: The incidence of needle-track seeding after US-guided procedures in HCC was 0.14%. En-bloc wide excision seems to be the optimal treatment for minimizing the probability of tumor recurrence due to needle-track seeding.

Adult , Biopsy, Fine-Needle/adverse effects , Carcinoma, Hepatocellular/secondary , Female , Humans , Liver Neoplasms/pathology , Male , Middle Aged , Neoplasm Seeding , Retrospective Studies , Skin Neoplasms/secondary , Tomography, X-Ray Computed
Braz. j. med. biol. res ; 43(4): 403-408, Apr. 2010. ilus, tab, graf
Article in English | LILACS | ID: lil-543572


A correlation between cancer and hypercoagulability has been described for more than a century. Patients with cancer are at increased risk for thrombotic complications and the clotting initiator protein, tissue factor (TF), is possibly involved in this process. Moreover, TF may promote angiogenesis and tumor growth. In addition to TF, thrombin seems to play a relevant role in tumor biology, mainly through activation of protease-activated receptor-1 (PAR-1). In the present study, we prospectively studied 39 lung adenocarcinoma patients in relation to the tumor expression levels of TF and PAR-1 and their correlation with thrombosis outcome and survival. Immunohistochemical analysis showed TF positivity in 22 patients (56 percent), most of them in advanced stages (III and IV). Expression of PAR-1 was found in 15 patients (39 percent), most of them also in advanced stages (III and IV). Remarkably, no correlation was observed between the expression of TF or PAR-1 and risk for thrombosis development. On the other hand, patients who were positive for TF or PAR-1 tended to have decreased long-term survival. We conclude that immunolocalization of either TF or PAR-1 in lung adenocarcinoma may predict a poor prognosis although lacking correlation with thrombosis outcome.

Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Adenocarcinoma/complications , Lung Neoplasms/complications , Receptor, PAR-1/metabolism , Thromboplastin/metabolism , Thrombosis/etiology , Adenocarcinoma/metabolism , Immunohistochemistry , Lung Neoplasms/metabolism , Neoplasm Seeding , Prognosis , Prospective Studies , Receptor, PAR-1/analysis , Thromboplastin/analysis , Thrombosis/metabolism
International Journal of Pathology. 2010; 8 (1): 9-12
in English | IMEMR | ID: emr-109983


To assess the level of serum lactate dehydrogenase 2 [LD2] in the patients of NHL with and without bone marrow infiltration. Lactate Dehydrogenase [LDH] is commonly increased in patients with haemopoietic malignancies and has been shown to be of prognostic value in patients with Non- Hodgkin lymphoma [NHL] especially. Serum LD2 isoenzyme level was determined in already diagnosed 60 patients of NHL. Patients were divided into two groups, 30 patients with bone marrow infiltration [group B] and remaining without infiltration [group C]. The values were compared with 20 healthy age and sex matched contrtols [groupA]. The estimations were made prior to the institution of chemotherapy. LD2 level was significantly raised in NHL patients compared with controls. There was also significant difference when the values were compared between the patients of NHL with and without bone marrow infiltration. The levels showed positive correlation with the extent of the disease. We conclude that the above mentioned non invasive parameter is useful indicator of the extent of the disease

Humans , Male , Female , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/blood , Neoplasm Seeding , Biomarkers, Tumor , Bone Marrow , Cross-Sectional Studies
Rev. bras. colo-proctol ; 29(4): 493-496, out.-dez. 2009. ilus
Article in Portuguese | LILACS | ID: lil-542675


Os autores relatam um caso de metástase de adenocarcinoma de reto para mandíbula, manifestação de rara incidência e que é sub-diagnosticada. Demonstram a radioterapia local como paliação e recuperação da função mastigatória.

The authors report a case of metastatic adenocarcinoma of the rectum to the mandible, a rare presentation of the disease that is almost always underestimated. Authors demonstrate local radiotherapy for palliation with recovery of the masticatory function.

Humans , Female , Middle Aged , Adenocarcinoma , Colorectal Surgery , Neoplasm Metastasis , Neoplasm Seeding , Mandibular Injuries/diagnosis
New Egyptian Journal of Medicine [The]. 2009; 40 (1 Supp.): 60-70
in English | IMEMR | ID: emr-113152


We evaluated the prognostic value of cyclin D1, epidermal growth factor receptor [EGFR] and MIB expression in Late Stage breast carcinoma, and their relationship with clinicopathologic response to neoadjuvant chemotherapy. We identified 45 patients who presented with locally advanced breast cancer [T2-T4], diagnosed with core needle biopsies, and treated with neoadjuvant chemotherapy, followed by conservative breast surgery [27/45,60%] with axillary lymph node dissection or modified radical mastectomy [18/45, 40%]. Complete pathologic response was defined as absence of invasive carcinoma at resection, while incomplete pathologic response was defined as having any invasive carcinoma. Cases were immunostained for cyclin D1, EGFR and MIB-1. Cyclin D1 ovcrexpression was found in 47% [21/45] of the cases and correlated with positive estrogen receptor [ER] expression [p < 0.01]. EGFR was positive in 16/45 [36%] of the cases which was expressed in the cytoplasm of the cancer cells, with occasional cell membrane staining. MIB-1 [>20%] was expressed in 15/45 [33%] of the cases. There were significant association between cyclin D1 overexpression and poor pathologic response [r=0.43, P=0.006], Cyclin D1 has significant adverse effect on overall survival and relapse-free survival [Log rank, p=0.05]. Overall, cyclin D1 overexpression was not associated with other clinicopathological features. EGFR was significantly expressed in ER and PR negative tumors [r=0.68 and 0.36, respectively]. Both EGFR and MIB-1 showed no significant correlation with pathologic response. Our findings indicate that cyclin D1 overexpression correlates with poor response to neoadjuvant chemotherapy and a worse survival in locally advanced breast cancer patients [T2-T4]

Humans , Female , Cyclin D1/genetics , Neoadjuvant Therapy/methods , Survival , Neoplasm Seeding , Immunohistochemistry/methods
Article in Korean | WPRIM | ID: wpr-181068


Hepatocellular carcinoma (HCC) rarely invades the gastrointestinal (GI) tract. It occurs in 0.7% to 2% of clinical HCC cases. Moreover, gastric invasion with GI hemorrhage via peritoneal seeding is very rare. We report the case of 67-year-old woman who had a history of HCC rupture and was admitted due to left upper quadrant abdominal pain. The patient was diagnosed with three omental metastatic masses and underwent hepatic segmentectomy and omental tumorectomy. Two months later, the patient had massive melena, and an esophagogastroduodenoscopy showed very large ulcerated friable mass on the gastric body. The histology was consistent with the diagnosis of metastatic HCC. The patient died from persistent GI hemorrhage 93 days after the admission. This case illustrates the very rare event of peritoneal seeding of a ruptured HCC causing direct invasion of the stomach, followed by GI hemorrhage.

Aged , Carcinoma, Hepatocellular/diagnosis , Female , Gastrointestinal Hemorrhage/diagnosis , Gastroscopy , Humans , Liver Neoplasms/diagnosis , Neoplasm Seeding , Peritoneal Neoplasms/diagnosis , Stomach Neoplasms/diagnosis , Tomography, X-Ray Computed