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Article in English | WPRIM | ID: wpr-147187


The anticarcinogenic effects and mechanisms of the biotechnological drugs of Panax ginseng C.A. Meyer cultivated in Russia, bioginseng, panaxel and panaxel- 5, were studied. Bioginseng was produced from a tissue culture of ginseng root cultured on standard medium, whereas panaxel and panaxel-5 were produced from ginseng tissue root cultures using standard mediums enriched with 2-carboxyethylgermanium sesquioxide and 1-hydroxygermatran-monohydrate respectively. All three ginseng drugs inhibited the development of mammary tumors induced by intramammary injections of N-methyl-N-nitrosourea (MNU) in rats, the development of the brain and spinal cord tumors induced by transplacental administration of N-ethyl-N-nitrosourea (ENU) in rats, and the development of uterine, cervical and vaginal tumors induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene (DMBA) in mice. The ginseng drugs induced the cytotoxic activity of macrophages in mice, enhanced T-lymphocyte rosette formation in guinea pigs exposed to cyclophosphamide, and stimulated the production of thyroid hormones in rats. These mechanisms may contribute to the anticarcinogenic action of the ginseng drugs. The organic germanium compounds present in panaxel and panaxel-5 did not potentiate the anticarcinogenic or immuno- stimulatory effects as much as biogeinseng. Preliminary clinical trials with panaxel and bioginseng were carried out in patients with precancerous lesions of the esophagus and endometrium. Panaxel was found to have a strong therapeutic effect in patients suffering from chronic erosive esophagitis. Bioginseng induced the regression of adenomatous-cystic hyperplasia of the endometrium in some patients. Thus, we conclude that the drugs of ginseng appear to hold considerable promise for future cancer chemoprevention.

Adenocarcinoma/chemically induced , Adult , Animals , Antineoplastic Agents, Phytogenic/therapeutic use , Cells, Cultured , Uterine Cervical Neoplasms/chemically induced , Clinical Trials as Topic , Cytotoxicity Tests, Immunologic , Disease Models, Animal , Endometrial Neoplasms/pathology , Endometrium/pathology , Esophageal Neoplasms/pathology , Esophagus/pathology , Estradiol/blood , Female , Fibroadenoma/chemically induced , Humans , Macrophages, Peritoneal/cytology , Male , Mammary Neoplasms, Experimental/chemically induced , Mice , Mice, Inbred C57BL , Neoplasms, Experimental/chemically induced , Nervous System Neoplasms/chemically induced , Panax/metabolism , Precancerous Conditions/pathology , Rats , Culture Techniques , Uterine Neoplasms/chemically induced , Vaginal Neoplasms/chemically induced
Arq. neuropsiquiatr ; 58(2B): 412-7, jun. 2000. tab
Article in English | LILACS | ID: lil-264438


OBJECTIVES: The industrialization process and nervous system cancer (NSC) mortality in a urban region of Brazil. METHOD: From registries of the State System of Data Analysis Foundation (SEADE), 103 males deaths by NSC (ICD-9) in Baixada Santista (BS), from 1980 to 1993 were selected. Mortality ratios were calculated comparing the standardized mortality rate for ages over 10 years old (G1) and for the age group from 35 to 64 years old, in the industrialized and non-industrialized areas in three periods: 1980-1993, 1980-86, 1987-93. RESULTS: A statiscally significant high mortality was observed in the industrialized area, for ages over 10 in all periods and only from 1980 to 1993 for ages from 34 to 64. The highest mortality ratio occurred from 1980-86 for ages over 10 - 4.12 (CI 1.79-9.42). CONCLUSION: High mortality was probably related to the environmental and occupational exposure to many organic and inorganic chemical substances, considered carcinogenics, such as aliphatic and aromatic hydrocarbons, organochlorinated, formaldehyde, nitrogenated compounds and heavy metals, found in the port and industrial complex. We discuss the importance of case-control studies in characterizing the association of these and other risk factors in the determination of NSC.

Humans , Male , Child , Adolescent , Adult , Middle Aged , Carcinogens/adverse effects , Industry , Nervous System Neoplasms/mortality , Occupational Diseases/mortality , Occupational Exposure , Brazil/epidemiology , Nervous System Neoplasms/chemically induced , Occupational Diseases/chemically induced , Risk Factors , Urban Health