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Acta Physiologica Sinica ; (6): 903-917, 2023.
Article in Chinese | WPRIM | ID: wpr-1007799


Aging is a natural process accompanied with a progressive deterioration of cognitive functions. With an aging population, more and more elderly people are suffering from cognitive impairment. Previous studies have paid more attention to the impact of inflammation and oxidative stress on cognitive function during aging. Recently, it has been discovered that neurovascular coupling (NVC), a mechanism regulating cerebral blood flow, may play a significant role in aging-related cognitive impairment. NVC responses regulate the supply of energy substances and oxygen during brain activity, which in turn enhances cognitive function. However, as people grow older, NVC responses gradually weaken, which may be one of the mechanisms underlying aging-induced cognitive impairment. Given the important role of NVC responses in the brain, it is necessary to search for intervention methods that can improve NVC responses and promote cognitive function. Exercise is an effective means to delay aging and improve cognitive function. It also has a certain promoting effect on NVC responses. This article reviews the regulatory mechanisms of NVC responses, the relationship between NVC responses and cognitive function, and explores the effects of aging and exercise intervention on NVC responses, hoping to provide new research ideas for exercise intervention to improve NVC responses and promote cognitive function in the elderly.

Humans , Aged , Neurovascular Coupling/physiology , Aging , Cerebrovascular Circulation/physiology , Cognition , Brain
Journal of Biomedical Engineering ; (6): 228-236, 2022.
Article in Chinese | WPRIM | ID: wpr-928218


Working memory is an important foundation for advanced cognitive function. The paper combines the spatiotemporal advantages of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) to explore the neurovascular coupling mechanism of working memory. In the data analysis, the convolution matrix of time series of different trials in EEG data and hemodynamic response function (HRF) and the blood oxygen change matrix of fNIRS are extracted as the coupling characteristics. Then, canonical correlation analysis (CCA) is used to calculate the cross correlation between the two modal features. The results show that CCA algorithm can extract the similar change trend of related components between trials, and fNIRS activation of frontal pole region and dorsolateral prefrontal lobe are correlated with the delta, theta, and alpha rhythms of EEG data. This study reveals the mechanism of neurovascular coupling of working memory, and provides a new method for fusion of EEG data and fNIRS data.

Electroencephalography/methods , Memory, Short-Term , Neurovascular Coupling/physiology , Prefrontal Cortex , Spectroscopy, Near-Infrared/methods
Acta cir. bras ; 30(11): 736-742, Nov. 2015. graf
Article in English | LILACS | ID: lil-767603


PURPOSE: To evaluate the effects of PHA-543613 (α7-nAChR agonist) and galantamine (acetylcholinesterase inhibitor (AChEI)) on recognition memory and neurovascular coupling (NVC) response in beta-amyloid (Aβ) 25-35-treated mice. METHODS: PHA-543613 (1 mg/kg, i.p.), and galantamine (3 mg/kg, s.c.), effects were tested in Aβ25-35 mice model of AD. α7-nAChR antagonist, methyllycaconitine (MLA) (1 mg/kg, i.p.), was used for evaluation of receptor blockade effects. Recognition memory in animals was assessed by the novel object recognition (NOR) task. NVC response was analyzed by laser-doppler flow meter in barrel cortex by whisker stimulation method. RESULTS: Both, PHA-543613 and galantamine improve recognition memory in Aβ-treated animals. However, the advantageous effects of PHA-543613 were significantly higher than galantamine. Also, pretreatment with MLA reversed both galantamine and PHA-543613 effects on NOR. Impaired NVC response in AD animals was improved by PHA-543613 and galantamine. However, MLA pretreatment disrupts this function. CONCLUSION: Activation of α7-nAChR improved recognition memory possible through enhancement of neurovascular response in Alzheimer's disease in animals.

Animals , Male , Amyloid beta-Peptides , Bridged Bicyclo Compounds, Heterocyclic/pharmacology , Cholinesterase Inhibitors/pharmacology , Galantamine/pharmacology , Memory Disorders/drug therapy , Neurovascular Coupling/drug effects , Peptide Fragments , Quinuclidines/pharmacology , /metabolism , Alzheimer Disease/drug therapy , Alzheimer Disease/physiopathology , Disease Models, Animal , Laser-Doppler Flowmetry , Mice, Inbred BALB C , Memory Disorders/physiopathology , Neuropsychological Tests , Neurovascular Coupling/physiology , Reproducibility of Results , Recognition, Psychology/drug effects , Time Factors , Treatment Outcome