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1.
Rev. habanera cienc. méd ; 17(4): 591-602, jul.-ago. 2018. tab
Article in Spanish | LILACS (Americas) | ID: biblio-978554

ABSTRACT

Introducción: Estudios epidemiológicos han señalado que la obesidad abdominal es el factor de riesgo más preponderante en los países latinoamericanos y el que mejor explica la ocurrencia de un primer infarto agudo de miocardio. Objetivo: Determinar el riesgo de enfermedad cardiovascular por la medición de la circunferencia abdominal en el Consultorio 22 del Policlínico Docente Aleida Fernández Chardiet del municipio La Lisa, La Habana, Cuba, en 2016. Material y métodos: Se realizó un estudio observacional descriptivo, de corte transversal en personas mayores de 17 años de edad. El universo estuvo constituido por 538 personas. Se utilizaron distribuciones de frecuencias, cálculos porcentuales y el test de Chi Cuadrado. Resultados: De acuerdo con el valor de la circunferencia abdominal, 42,9 por ciento de las personas presentó un riesgo de enfermedad cardiovascular incrementado. El riesgo incrementado predominó en el sexo masculino (48 por ciento). Solo el 16,5 por ciento de los pacientes diabéticos tuvo un riesgo bajo. El 50,6 por ciento de los pacientes con hipertensión arterial y 45,4 por ciento de los fumadores presentaron un riesgo de enfermedad cardiovascular incrementado. Conclusiones: El riesgo incrementado de enfermedad cardiovascular, según la medida de la circunferencia abdominal, predominó en la mayoría de los pacientes estudiados, fundamentalmente en los pacientes del sexo masculino, los diabéticos, los hipertensos y los fumadores. Se observó una relación estadísticamente significativa entre el riesgo de enfermedad cardiovascular, encontrado por la obesidad abdominal y la edad, el sexo, la Diabetes Mellitus y la hipertensión arterial(AU)


Introduction: Epidemiological studies have demonstrated that abdominal obesity is the most important risk factor and the one that best explains the occurrence of a first acute myocardial infarction in Latin American countries. Objective: To determine the risk of cardiovascular disease by measuring the abdominal circumference in Doctor's Office 22 of Aleida Fernández Chardiet Teaching Polyclinic, La Lisa municipality, Havana, Cuba, in 2016. Material and Methods: An observational descriptive cross-sectional study was conducted in people older than 17 years old. The universe of study was composed of 538 persons. Distributions of frequencies, percentage calculations, and the Chi-square test were used. Results: With regard to the value of abdominal circumference, 42,9 percent of people presented a high risk of cardiovascular disease, which predominated in the male sex (48,0 percent). Only 16,5 percent of diabetic patients presented a low risk. The 50,6 percent of patients with arterial hypertension, and the 45,4 percent of smokers presented a high risk. Conclusions: Regarding the evaluation of the abdominal circumference, a high risk of cardiovascular disease was observed in the majority of population studied, especially in the male sex, diabetics, hypertensive patients, and smokers. A statistically significant relationship was observed in patients with risk of cardiovascular disease due to abdominal obesity and age, sex, Diabetes Mellitus, and arterial hypertension.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Risk Assessment/methods , Obesity, Abdominal/complications , Myocardial Infarction/etiology , Epidemiology, Descriptive , Cross-Sectional Studies , Abdominal Circumference , Observational Study , Myocardial Infarction/complications
2.
An. bras. dermatol ; 93(2): 205-211, Mar.-Apr. 2018. tab
Article in English | LILACS (Americas) | ID: biblio-887203

ABSTRACT

Abstract: Background: Coexistence of obesity, hypertension, insulin resistance and dyslipidemia is defined as metabolic syndrome (MBS), which is among the important risk indicators for cardiovascular diseases, diabetes and stroke. Smoking and alcohol consumption are the other factors which lead to an increase in the risk of cardiovascular disease. Objective: To investigate the prevalence of metabolic syndrome, smoking and alcohol consumption in psoriasis patients and the relationship between disease severity and these factors. Methods: This cross-sectional study enrolled 563 patients with chronic plaque-type psoriasis, all of which completed a questionnaire and underwent a complete physical examination. Data about MBS components, psoriasis severity/duration, smoking and alcohol consumption, and cardiovascular diseases were recorded. Results: A total of 563 patients with ages ranging from 18 to 78 years were evaluated. Metabolic syndrome was found in 12.6% of the patients [central obesity (38.7%), hypertension (14.3%), dyslipidemia (18.6%), diabetes (9.2%)], while 50.3% had smoking, and 3.3% had alcohol consumption. Patients with metabolic syndrome were older and more likely to have a longer disease duration than those without metabolic syndrome (p<0.05 for each). The prevalence of metabolic syndrome was higher in women than in men. Psoriasis was more severe in patients with central obesity, diabetes and smoking than in those without (p<0.05 for each). Study Limitations: Retrospective design. Conclusions: Our results indicate that MBS is a risk factor for psoriasis patients with advanced age. The relationship between disease severity and obesity, diabetes, and smoking in psoriasis patients indicates that the patients should be informed about the potential metabolic risks and receive therapies for behavioral changes besides anti-psoriatic treatment in order to minimize these risks.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Psoriasis/epidemiology , Alcohol Drinking/epidemiology , Smoking/epidemiology , Metabolic Syndrome/epidemiology , Psoriasis/complications , Time Factors , Turkey/epidemiology , Alcohol Drinking/adverse effects , Cardiovascular Diseases/etiology , Smoking/adverse effects , Sex Factors , Epidemiologic Methods , Risk Factors , Age Factors , Sex Distribution , Age Distribution , Metabolic Syndrome/complications , Diabetes Mellitus/epidemiology , Dyslipidemias/complications , Dyslipidemias/epidemiology , Obesity, Abdominal/complications , Obesity, Abdominal/epidemiology , Hypertension/complications , Hypertension/epidemiology
3.
Cad. Saúde Pública (Online) ; 34(4): e00067617, 2018. tab
Article in Portuguese | LILACS (Americas) | ID: biblio-889945

ABSTRACT

O objetivo deste estudo foi estimar a prevalência do fenótipo cintura hipertrigliceridêmica (FCH) em participantes do Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil), identificar fatores de risco associados e comparar com outros indicadores de risco cardiovascular e metabólico. Trata-se de um estudo transversal com dados da linha de base de uma coorte de servidores públicos. O FCH é definido pela presença simultânea de circunferência da cintura (CC) aumentada (≥ 80cm para mulheres, ≥ 90cm para homens de acordo com a Federação Internacional de Diabetes - IDF; e ≥ 88cm para mulheres, ≥ 102cm para homens de acordo com o Programa Nacional de Educação sobre o Colesterol dos Estados Unidos - NCEP) e hipertrigliceridemia. A associação entre as variáveis independentes e FCH foi testada por meio de modelos de regressão logística multivariada. O FCH foi comparado também com outros indicadores de risco cardiovascular e metabólico por meio de testes de correlação, índice kappa, sensibilidade e especificidade. Após exclusões, foram analisados 12.811 participantes. A prevalência do FCH variou de 24,7% (IDF) a 13,3% (NCEP). FCH foi associado a ter idade mais avançada, ao consumo excessivo de álcool, ser ex-fumante, apresentar HDL baixo, não-HDL alto e PCR aumentado, independente do sexo ou critério de definição. FCH associou-se a indicadores de risco cardiovascular, especialmente à síndrome metabólica. A elevada prevalência de FCH e sua associação com indicadores de risco cardiovascular, especialmente com a síndrome metabólica, apoia sua utilização como ferramenta de triagem de risco cardiometabólico na prática clínica.


This study's objectives were to estimate the prevalence of hypertriglyceridemic waist (HTW) phenotype in participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), identify associated risk factors, and compare with other cardiovascular and metabolic risk indicators. This was a cross-sectional study with baseline data from a cohort of public employees. HTW is defined as the simultaneous presence of increased waist circumference (WC) (≥ 80cm for women, ≥ 90cm for men according to the International Diabetes Federation - IDF; and ≥ 88cm for women, ≥ 102cm for men according to the U.S. National Cholesterol Education Program - NCEP) and hypertriglyceridemia. Associations between independent variables and HTW were tested with multivariate logistic regression models. HTW was also compared to other cardiovascular and metabolic risk indicators by means of correlation tests, kappa index, sensitivity, and specificity. After exclusions, 12,811 participants were analyzed. Prevalence of HTW ranged from 24.7% (IDF) to 13.3% (NCEP). HTW was associated with age, excessive alcohol consumption, former smoking, low HDL, non-high HDL, and increased C-reactive protein, independently of gender or the criterion used to define HTW. HTW was associated with cardiovascular risk indicators, especially metabolic syndrome. The high prevalence of HTW and its association with cardiovascular risk indicators, especially metabolic syndrome, supports its use as a cardiometabolic risk screening tool in clinical practice.


El objetivo de este estudio fue estimar la prevalencia del fenotipo cintura hipertrigliceridémica (FCH), en participantes del Estudio Longitudinal de la Salud del Adulto (ELSA-Brasil), identificar factores de riesgo asociados, y compararlo con otros indicadores de riesgo cardiovascular y metabólico. Se trata de un estudio transversal con datos de la línea de referencia de una cohorte de empleados públicos. El FCH se define por la presencia simultánea de circunferencia de la cintura (CC) aumentada (≥ 80cm para mujeres, ≥ 90cm para hombres de acuerdo con la Federación Internacional de Diabetes - IDF; y ≥ 88cm para mujeres, ≥ 102cm para hombres de acuerdo con el Programa National de Educación sobre el colesterol de los EE.UU. - NCEP) e hipertrigliceridemia. La asociación entre las variables independientes y FCH fue probada mediante modelos de regresión logística multivariada. El FCH se comparó también con otros indicadores de riesgo cardiovascular y metabólico, mediante pruebas de correlación, índice kappa, sensibilidad y especificidad. Tras las exclusiones, se analizaron a 12.811 participantes. La prevalencia del FCH varió de un 24,7% (IDF) a un 13,3% (NCEP). El FCH se asoció a tener una edad más avanzada, al consumo excesivo de alcohol, ser ex-fumador, presentar HDL bajo, no-HDL alto y PCR aumentado, independiente del sexo o criterio de definición. FCH se asoció a indicadores de riesgo cardiovascular, especialmente al síndrome metabólico. La elevada prevalencia de FHC y su asociación con indicadores de riesgo cardiovascular, especialmente con el síndrome metabólico, apoya su utilización como herramienta de clasificación de riesgo cardiometabólico en la práctica clínica.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Cardiovascular Diseases/etiology , Metabolic Syndrome/etiology , Waist Circumference , Hypertriglyceridemic Waist/complications , Phenotype , Socioeconomic Factors , Cross-Sectional Studies , Risk Factors , Longitudinal Studies , Obesity, Abdominal/complications
5.
Rev. argent. endocrinol. metab ; 54(4): 160-168, dic. 2017. tab
Article in Spanish | LILACS (Americas) | ID: biblio-957983

ABSTRACT

Introducción: El índice de adiposidad visceral (VAI) es un método sencillo y costo-efectivo en la determinación de adiposidad visceral. El objetivo de este estudio es evaluar la relación entre el VAI con diversos factores de riesgo cardiovascular, variables sociodemográficas y hábitos psicobiológicos en la población adulta de la ciudad de Cuenca, Ecuador. Materiales y métodos: Se realizó un estudio descriptivo transversal en 318 individuos adultos seleccionados mediante muestreo aleatorio y multietápico, a quienes se les realizó evaluación clínica, evaluación antropométrica y de laboratorio. El VAI se determinó utilizando las fórmulas propuestas que emplean circunferencia abdominal, el índice de masa corporal, los triacilglicéridos y HDL-C. Se realizó un modelo de regresión logística múltiple para determinar los principales factores asociados a adiposidad visceral en sus valores más elevados. Resultados: En los 318 individuos, el promedio del VAI fue 2,57 (1,66-3,94), con valores más elevados para el sexo femenino. En el modelo de regresión logística múltiple, los factores de riesgo significativos para VAI moderado-alto fueron: la edad (> 60 años: OR = 3,87; IC del 95%: 1,15-12,96; p = 0,03), el consumo calórico, la glucemia alterada en ayuno y la actividad física en ocio. Conclusión: El VAI es un método útil para definir a aquellos sujetos con adiposidad visceral en nuestra región. La edad, el consumo calórico diario y la glucemia alterada en ayuno son los principales factores asociados con los valores más elevados delíndice, mientras que la actividad física durante el ocio representó un factor protector para clasificar a los sujetos en los estadios más avanzados.


Introduction: The visceral adiposity index (VAI) is a simple and cost effective method for the determination of visceral adiposity. The objective of this study is to evaluate the relationship between VAI and different cardiovascular risk factors, sociodemographic variables, and psychobiological habits in the adult population of the city of Cuenca, Ecuador. Materials and methods: A descriptive cross-sectional study was performed on 318 adult individuals selected by multistage random sampling, who underwent a clinical, anthropometric and laboratory evaluation. VAI was determined using the proposed formula that used abdominal circumference, body mass index, triglycerides, and HDL-Cholesterol. A multiple logistic regression model was used to determine the main factors associated with the highest values of visceral adiposity. Results: The mean VAI was 2.57 (1.66-3.94) in the 318 individuals studied, with higher values for females. In the multiple logistic regression model, significant risk factors for moderatehigh VAI were: age (>60 years: OR = 3.87, 95% CI: 1.15-12.96, P=.03), calorie intake, impaired fasting glucose, and leisure time physical activity. Conclusion: VAI is a useful method to define those subjects with visceral adiposity in our region. Age, daily calorie intake, and impaired fasting glucose are the main factors associated with higher index values, while leisure time physical activity was a protective factor for classifying subjects in the more advanced stages.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Body Fat Distribution/statistics & numerical data , Obesity, Abdominal/complications , Energy Intake/physiology , Exercise/physiology , Ecuador/epidemiology , Obesity, Abdominal/diagnosis
6.
Rev. argent. endocrinol. metab ; 54(4): 176-183, dic. 2017. graf, tab
Article in English | LILACS (Americas) | ID: biblio-957985

ABSTRACT

Aim: Visceral obesity is one of the most intensely researched cardiometabolic risk factors in recent years; nonetheless, its accurate assessment remains a challenge in regions were socioeconomic conditions hinder the widespread use of diagnostic methods for this purpose, such as imaging tests. In this setting, Visceral Adiposity Index (VAI) may be a useful tool. Thus, the objective of this study was to determine the VAI cutoff in adult population from Maracaibo City, Venezuela. Methods: This is a descriptive, cross-sectional study with multi-staged sampling; 2026 subjects of both genders aged ≥18 years were selected from this database and had their VAI calculated. In order to determine VAI cutoffs, subsamples of metabolically healthy and sick individuals were determined, with 599 and 286 subjects, respectively. Gender-specific and general ROC curves were plotted in order to identify the most suitable cutoff according to sensitivity and specificity. Results: Median VAI in the selected sample was 1.67 (0.97-2.78). The optimal cutoff was determined to be 1.91, with 70.3% sensitivity, 70.3% specificity [AUC = 0.777 (0.745-0.808)]. No differences were found between genders. Analysis by age revealed VAI to have greater predictive power among subjects aged < 30 years (cutoff: 1.53), 78.6% sensitivity, 72.8% specificity [AUC = 0.797 (0.709-0.884)]. Conclusion: We suggest a VAI cutoff of 1.9 for define dysfunctional adiposity in our population, with age being an important factor in the epidemiologic behavior of this variable, particularly in younger individuals.


Objetivo: La obesidad central es uno de los factores de riesgo cardiometabólicos emergente más evaluado durante los últimos años, sin embargo, su medición de forma precisa resulta un reto en aquellas poblaciones cuyas condiciones económicas dificultan la realización de métodos diagnósticos complejos, como pruebas de imagen. Por ello el objetivo de este estudio es determinar el punto de corte del índice de adiposidad visceral (VAI) en sujetos adultos de la ciudad de Maracaibo, Venezuela. Métodos: Se seleccionó a 2.026 individuos de ambos sexos, mayores de 18 años, de la base de datos del Estudio de prevalencia de síndrome metabólico en la ciudad de Maracaibo, un estudio descriptivo, transversal, con muestreo multietápico. El VAI se calculó para cada sexo y para la estimación del punto corte se seleccionó a 599 sujetos sanos y 286 enfermos, realizándose curvas COR para identificar el mejor valor de acuerdo con la sensibilidad y la especificidad. Resultados: El promedio de VAI en la muestra seleccionada fue 1,67 (0,97-2,78). El punto de corte fue 1,91 (70,3% de sensibilidad y 70,3% de especificidad) con AUC = 0,777 (0,745-0,808), sin diferencias en el punto de corte según sexo. En el análisis por grupos etarios la mayor capacidad predictiva fue para el grupo < 30 años con AUC = 0,797 (0,709-0,884), con un punto de corte de 1,53 (78,6% de sensibilidad y 72,8% de especificidad). Conclusión: El punto de corte indicado para VAI en nuestra población es de 1,9; considerando la edad como un factor importante en su comportamiento, especialmente en los grupos más jóvenes.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Metabolic Syndrome/epidemiology , Obesity, Abdominal/complications , Venezuela/epidemiology , Cross-Sectional Studies/statistics & numerical data , Obesity, Abdominal/diagnosis
7.
Rev. Nutr. (Online) ; 30(2): 209-218, Mar.-Apr. 2017. tab
Article in English | LILACS (Americas) | ID: biblio-845585

ABSTRACT

ABSTRACT Objective: To analyze the association between excess abdominal fat and healthcare costs related to hypertension and diabetes Mellitus in older adults. Methods: These cross-sectional analyses are part of the Health, Wellbeing and Aging Study conducted in São Paulo, Brazil, with 806 older adults with self-reported hypertension and diabetes Mellitus. The study included the annual costs with medicines, hospital admissions, and outpatient services for hypertension and diabetes Mellitus control. Excess abdominal fat was diagnosed based on waist circumference. Level of physical activity, age, and gender were considered covariates. The sample was divided into two groups according to waist circumference. Multiple logistic regression analyzed the associations between annual costs and waist circumference. Results: The cost of services and hospitalizations (R$551.05; 95%CI=418.27-683.83) and total costs (R$817.77; 95%CI=669.21-966.33) were higher in the excess abdominal fat group. Older adults with high waist circumference had higher odds of increasing annual costs due to medicines (OR=2.6; 95%CI=1.13-3.77), regardless of gender, age, and level of physical activity. Conclusion: Healthcare costs for treating hypertension and diabetes Mellitus in older adults are higher in the presence of excess abdominal fat.


RESUMO Objetivo: Analisar a associação entre excesso de gordura abdominal e custos com saúde relacionados à hipertensão arterial sistêmica e ao diabetes Mellitus em idosos. Métodos: Estudo transversal que faz parte do Estudo Saúde, Bem-estar e Envelhecimento realizado em São Paulo, São Paulo, incluindo 806 idosos com autorreferência à hipertensão arterial sistêmica e ao diabetes Mellitus. Os custos anuais com medicamentos, internações e serviços ambulatoriais para o controle dessas patologias foram considerados. O excesso de gordura abdominal foi diagnosticado segundo os valores de circunferência da cintura. Nível de atividade física, sexo e idade foram considerados como covariáveis. Os idosos foram divididos em dois grupos segundo a circunferência da cintura, sendo que a análise de regressão logística múltipla verificou associações entre essa medida e custos anuais. Resultados: Os custos com serviços e hospitalizações (R$551,05; IC95%=418,27-683,83) e custos totais (R$817,77; IC95%=669,21-966,33) foram maiores no grupo de idosos com excesso de gordura abdominal. Os idosos com maior circunferência da cintura apresentaram maior risco para custos anuais superiores devido ao uso de medicamentos (OR=2.06; IC95%=1.13-3.77), independentemente do sexo, idade ou nível de atividade física. Conclusão: Os custos com saúde para hipertensão arterial sistêmica e diabetes Mellitus em idosos são superiores quando existe excesso de gordura abdominal.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Obesity, Abdominal/complications , Aging , Public Health , Health Care Costs , Diabetes Mellitus , Hypertension
8.
Nutrire Rev. Soc. Bras. Aliment. Nutr ; 41: 1-9, Dec. 2016. ilus
Article in English | LILACS (Americas) | ID: biblio-880585

ABSTRACT

Obesity prevalence has increased worldwide over the last decades and has reached alarming rates in low middle-income countries. Childhood has been affected by this epidemic, leading to premature dramatic health problems. Adipose tissue is currently considered as an endocrine organ modulating an inflammatory state and important metabolic processes (insulin resistance, hypertension, glucose intolerance) leading to consequences of the cardiovascular system. This situation may be worst if the excess of body fat distribution such as abdominal obesity (AO) is involved because it is associated with a more atherogenic risk profile determining the cardiometabolic risks mainly in children and adolescents. Hence, the knowledge regarding the association between AO and cardiometabolic factors aims to prevent and treat the obesity in this young population, avoiding early harmful consequences of adulthood health.


Subject(s)
Humans , Male , Female , Child , Adolescent , Cardiovascular Diseases/etiology , Obesity, Abdominal/complications , Obesity, Abdominal/metabolism , Metabolic Syndrome
9.
Int. j. cardiovasc. sci. (Impr.) ; 29(6): 471-476, nov.-dez.2016.
Article in Portuguese | LILACS (Americas) | ID: biblio-832410

ABSTRACT

A síndrome metabólica é uma comorbidade relacionada à obesidade com crescentes níveis mundiais. Além dos fatores ambientais, especula-se que as variáveis incluídas na síndrome metabólica (cintura, glicemia de jejum, HDL, triglicérides e valores pressóricos) possam ser moduladas por variantes genéticas. Recentemente foi reportado que alguns polimorfismos do gene do fator de crescimento de células pré-beta podem ter um papel modulador no metabolismo de glicose e lipídeos, além de influências no índice de massa corporal. Objetivo: Investigar a influência do polimorfismo rs4730153 do gene do fator de crescimento de células pré-beta nos níveis de glicemia, triglicérides, HDL e índice de massa corporal de indivíduos sedentários acima do peso. Métodos: Incluíram-se homens e mulheres brasileiros com índice de massa corporal > 24,9 kg/m², acima de 18 anos de idade, que não faziam uso de medicamentos para glicemia ou hipercolesterolemia. O polimorfismo rs4730153 foi amplificado por reação em cadeia de polimerase em tempo real utilizando kit de genotipagem. Os genótipos AA, AG e GG foram avaliados separadamente. Resultados: Foram incluídos 112 indivíduos com idade média de 40,52 ± 10,30 anos, sendo 77% mulheres. A frequência genotípica foi de 29,5, 41,0 e 29,5% (AA, AG e GG, respectivamente). Não foi observada nenhuma relação entre os valores de glicemia, triglicérides, HDL e índice de massa corporal nos diferentes alelos do SNP estudado. Conclusões: Apesar de relatos em estudos em outras etnias, no presente estudo não foi encontrada relação entre o polimorfismo rs4730153 do gene do fator de crescimento de células pré-beta nos níveis séricos de glicemia, triglicérides, HDL e índice de massa corporal em uma amostra da população brasileira com sobrepeso/obesidade.


Metabolic syndrome is an obesity-related comorbidity with increasing worldwide occurrence. In addition to environmental factors, it is speculated that the variables included in the metabolic syndrome (waist, fasting glycemia, HDL, triglycerides and blood pressure values) can be modulated by genetic variants. It has recently been reported that some polymorphisms of the pre-beta cell growth factor gene may play a modulatory role in glucose and lipid metabolism, as well as influence body mass index. Objective: To investigate the influence of the rs4730153 polymorphism of the pre-beta cell growth factor gene on the levels of glycemia, triglycerides, HDL and body mass index of overweight and sedentary individuals. Methods: Brazilian men and women with a body mass index >24.9 kg/m², over 18 years of age, who did not use medication for glycemia or hypercholesterolemia were included. The rs4730153 polymorphism was amplified by real-time polymerase chain reaction using a genotyping kit. Genotypes AA, AG and GG were evaluated separately. Results: A total of 112 individuals with a mean age of 40.52 ± 10.30 years were included, of which 77% were women. Genotype frequency was 29.5, 41.0 and 29.5% (AA, GA and GG, respectively). No association was observed between glycemia, triglycerides, HDL and body mass index in the different alleles of the studied SNP. Conclusions: Despite reports of studies in other ethnicities, in the present study no association was found between the rs4730153 polymorphism of the pre-beta cell growth factor gene and serum levels of glycemia, triglycerides, HDL and body mass index in a sample of the Brazilian population with overweight/obesity.


Subject(s)
Humans , Female , Adolescent , Adult , Cardiovascular Diseases/diagnosis , Metabolic Syndrome/blood , Metabolic Syndrome/pathology , Polymorphism, Genetic/genetics , Obesity, Abdominal/complications , Sedentary Behavior
11.
J. pediatr. (Rio J.) ; 92(2): 174-180, Mar.-Apr. 2016. tab, graf
Article in English | LILACS (Americas) | ID: lil-779899

ABSTRACT

Abstract Objective: To assess the association between general and abdominal obesity with high blood pressure in adolescents of both genders from the public school system. Methods: This was an epidemiological, descriptive, exploratory study, with a quantitative approach and local scope whose sample consisted of 481 high school students (aged 14–19), selected by using a random cluster sampling strategy. Blood pressure was measured through the use of automated monitor and was considered high when the pressure values were at or above the 95th percentile. The analyses were performed using the chi-squared test and binary logistic regression. Results: The prevalence of high blood pressure was 6.4%, and it was higher among boys (9.0% vs. 4.7%, p < 0.05). There was no significant difference between general (p = 0.903) and abdominal obesity (p = 0.157) when genders were compared. After adjusting for age, high blood pressure was associated with general (OR = 6.4; p < 0.001) and abdominal obesity (OR = 7.0; p < 0.001) only among boys, when comparing the fourth quartile with the first quartile of body mass index (≤18.6 kg/m2 vs. ≥23.5 kg/m2) and waist circumference (≤69 cm vs. ≥80.1 cm). Conclusion: It was observed that general and abdominal obesity are associated with high blood pressure only in boys, regardless of age.


Resumo Objetivo: Analisar a associação entre obesidade geral e abdominal com a pressão arterial elevada em adolescentes de ambos os gêneros da rede de ensino público. Métodos: Estudo epidemiológico, descritivo, exploratório, com abordagem quantitativa e abrangência municipal, cuja amostra foi constituída de 481 estudantes (14-19 anos) do ensino médio, selecionados por meio de uma estratégia de amostragem aleatória de cluster. A pressão arterial foi medida com equipamentos automáticos e considerada elevada quando os valores pressóricos estivessem iguais ou acima do percentil 95. As análises foram feitas com os testes de qui-quadrado e da regressão logística binária. Resultados: A prevalência de pressão arterial elevada foi de 6,4%, maior entre os rapazes (9% vs. 4,7%, p < 0,05). Não foi observada diferença significante entre a obesidade geral (p = 0,903) e abdominal (p = 0,157) quando comparados os gêneros. Após o juste pela idade, a pressão arterial elevada foi associada com a obesidade geral (OR = 6,4; p < 0,001) e abdominal (OR = 7,0; p < 0,001) apenas entre os rapazes, quando comparado o quarto quartil com o primeiro quartil do índice de massa corporal (≤ 18,6 Kg/m2 vs. ≥23,5 Kg/m2) e da circunferência da cintura (≤ 69 cm vs. ≥80,1 cm). Conclusão: Foi observado que a obesidade geral e abdominal está associada com a pressão arterial elevada apenas entre os rapazes, independentemente da idade.


Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Obesity, Abdominal/complications , Hypertension/etiology , Socioeconomic Factors , Brazil/epidemiology , Body Mass Index , Sex Factors , Prevalence , Risk Factors , Qualitative Research , Waist Circumference , Obesity, Abdominal/epidemiology , Hypertension/epidemiology
12.
Article in English | WPRIM (Western Pacific) | ID: wprim-85720

ABSTRACT

Although non-alcoholic fatty liver disease has been reported as a cardiometabolic risk factor, the effect of non-alcoholic fatty liver is yet to be clarified on abdominal obesity. Therefore, this study was conducted to investigate the longitudinal relationship of non-alcoholic fatty liver on the development of abdominal obesity. The study participants were composed of 11,212 Korean men without abdominal obesity. They were followed up from 2005 to 2010 to be monitored for the development of abdominal obesity according to their degree of non-alcoholic fatty liver disease (normal, mild, and moderate to severe). Cox-proportional hazard model was used to calculate the hazard ratios for abdominal obesity according to the degree of non-alcoholic fatty liver disease. While the average incidence was 15.5%, the incidence of abdominal obesity increased according to the degree of non-alcoholic fatty liver (normal: 11.6%, mild: 25.2%, moderate to severe: 41.0%, P < 0.001). Multivariable-adjusted hazard ratios for abdominal obesity independently increased proportionally to the degree of NAFLD (mild [1.07; 0.94-1.23], moderate to severe [1.58; 1.11-2.26], P for trend < 0.001). The risk of abdominal obesity increased proportionally to the degree of non-alcoholic fatty liver disease. This finding guarantees further studies to reveal the incidental relationship of abdominal obesity with non-alcoholic fatty liver disease.


Subject(s)
Adult , Asian Continental Ancestry Group , Cohort Studies , Demography , Follow-Up Studies , Humans , Incidence , Male , Non-alcoholic Fatty Liver Disease/complications , Obesity, Abdominal/complications , Proportional Hazards Models , Prospective Studies , Republic of Korea/epidemiology , Risk Factors , Waist Circumference
13.
Yonsei Medical Journal ; : 658-663, 2016.
Article in English | WPRIM (Western Pacific) | ID: wprim-21848

ABSTRACT

PURPOSE: To describe the relationship between the waist-to-height ratio (WHtR) and cardiometabolic risk factors (CMRFs) and to evaluate the validity of WHtR in identifying adolescents with metabolic syndrome. MATERIALS AND METHODS: We analyzed data from a pooled population of 4068 adolescents aged 10-19 years from the Korean National Health and Nutrition Examination Surveys conducted between 1998 and 2008. Overweight individuals were defined by body mass index (BMI) ≥85th percentile. Those with at least 2 CMRFs among hypertension, hyperglycemia, hypertriglyceridemia, and decreased high-density lipoprotein cholesterol (HDL-C) were classified as having multiple CMRFs. RESULTS: WHtR was significantly related to systolic blood pressure, HDL-C, and triglycerides in both non-overweight and overweight adolescents (all p<0.01). Among overweight adolescents, the area under the curve (AUC) for WHtR in identifying multiple CMRFs was significantly greater than that for BMI (p=0.014). Metabolic syndrome was more common in overweight adolescents with a WHtR of ≥0.5 than in those with a WHtR of <0.5 (p<0.001). In non-overweight adolescents, the prevalences of multiple CMRFs (p=0.001) and metabolic syndrome (p<0.001) were higher in those with a WHtR of ≥0.5 than in those with a WHtR of <0.5. Among those without central obesity, the prevalence of multiple CMRFs was higher in those with a WHtR of ≥0.5 than in those with a WHtR of <0.5 (p=0.021). CONCLUSION: WHtR is a simple and valid index for identifying adolescents with increased cardiometabolic risk and is related to CMRFs even in non-overweight adolescents. In adolescents already screened via BMI and waist circumference (WC), WHtR seems to be of additional help in discriminating those at higher cardiometabolic risk.


Subject(s)
Adolescent , Blood Pressure/physiology , Body Height , Body Mass Index , Cardiovascular Diseases/epidemiology , Child , Cholesterol, HDL/blood , Female , Humans , Hypertension/complications , Male , Metabolic Syndrome/epidemiology , Nutrition Surveys , Obesity, Abdominal/complications , Republic of Korea/epidemiology , Risk Factors , Triglycerides/blood , Waist Circumference/physiology , Waist-Height Ratio , Young Adult
14.
Arch. latinoam. nutr ; 65(3): 152-157, sep. 2015. ilus, graf
Article in Spanish | LILACS (Americas) | ID: lil-780111

ABSTRACT

La presencia de componentes cardiometabólicos condiciona un aumento del riesgo en la aparición de síndrome metabólico y las patologías asociadas. La insulinoresistencia, es probablemente, el mecanismo subyacente a las complicaciones derivadas de este síndrome, donde la acumulación adiposa abdominal se presenta como característica frecuente. El objetivo de este estudio fue determinar la capacidad predictiva de los índices antropométricos estimadores de distribución adiposa central versus el índice de masa corporal en la detección de síndrome metabólico en adultos chilenos. Se realizó un estudio de tipo descriptivo de corte transversal con 229 adultos, cuyos datos fueron obtenidos a través de una fuente de datos secundaria. Estos fueron analizados a través de correlación de Pearson y curva operador receptor estableciendo área bajo la curva. Los resultados mostraron una prevalencia de 58,3% de síndrome metabólico según NCEP-ATP III, donde los índices antropométricos como el índice cintura estatura (0,746), circunferencia de cintura (0,735) e índice de masa corporal (0,722) no presentaron diferencias significativas en la detección de síndrome metabólico. Se estableció mayor correlación de los factores cardiometabólicos con el índice cintura estatura y circunferencia cintura.


The presence of cardiometabolic components conditions the risk increase in the appearance of the metabolic syndrome and the associated pathologies. The insulin resistance is probably the subjacent mechanism to the complications derived from this syndrome, where the abdominal adipose accumulation is a common and frequent characteristic. The purpose of this study was to determine the predictive capability of the anthropometric estimating central adipose distribution indexes against the body mass index in the detection of the metabolic syndrome in Chilean adults. A descriptive crosssectional study was conducted on 229 adults, information obtained through a secondary database. There were analyzed through a Pearson correlation and receiver operating curves determining the area under the curve. The results showed the predominance of 58.3 % of the metabolic syndrome prevailed according to NCEP-ATP III, where the anthropometric indexes such as waist height index (0.746), waist circumference (0.735) and body mass index (0.722) did not show significant differences in the detection of the metabolic syndrome components. It did show a higher correlation of these cardio-metabolic factors with the waist height index and waist circumference.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Anthropometry , Cardiovascular Diseases/complications , Metabolic Syndrome/diagnosis , Metabolic Syndrome/etiology , Obesity, Abdominal/complications , Body Mass Index , Chile/epidemiology , Epidemiologic Methods , Metabolic Syndrome/epidemiology , Waist Circumference , Waist-Hip Ratio
15.
Int. j. cardiovasc. sci. (Impr.) ; 28(4): 282-289, jul.-ago.2015. tab
Article in Portuguese | LILACS (Americas) | ID: lil-776152

ABSTRACT

Estudos recentes têm demonstrado prováveis benefícios das atividades de alta intensidade, predominantemente anaeróbias na capacidade de oxidação de gorduras. Entretanto, o efeito do exercício predominantemente anaeróbio na redução da obesidade e do estado inflamatório ainda é pouco conhecido. Objetivos: Avaliar os efeitos do treinamento aeróbio vs. anaeróbio sobre os níveis da proteína C-reativa (PCR)de mulheres com obesidade central, e a associação de níveis de PCR com a composição corporal. Métodos: Ensaio clínico randomizado, com uma população formada por mulheres adultas, sedentárias e com obesidade central, matriculadas no Ambulatório Docente-assistencial da Escola Bahiana de Medicina e Saúde Pública. Estudadas 19 mulheres estratificadas aleatoriamente em dois grupos: Treinamento Contínuo (TCO - intensidade a -20% do limiar ventilatório - LV), ou Treinamento Intervalado (TIN - 2 min de estímulo a 120% do LVe 2 min de recuperação em 80% do LV), durante 10 semanas, duas vezes por semana, sessões de 20-40 minutos. Realizada avaliação médica e física, laboratorial e cardiorrespiratória antes e após a intervenção. Resultados: As medianas dos níveis de PCR foram, respectivamente, antes e depois do treino: TCO: 2,2mg/L(0,6-4,1 mg/L) vs. 2,1 mg/L (0,8-5,5 mg/L) p=0,75; TIN: 3,9 mg/L (0,7-8,6 mg/L) vs. 3,2 mg/L (1,2-5,7 mg/L)p=0,90. Não houve diferença significativa na comparação dos deltas (Δ) da PCR intergrupos, p=0,49. Não houve associação entre os níveis de PCR e demais variáveis pré-intervenção. Conclusão: Programas de exercícios com baixo volume, independentemente de suas intensidades, não alteramos níveis de PCR em mulheres com obesidade central...


Recent studies have shown probable benefits of high intensity, predominantly anaerobic activities in fat oxidationcapacity. However, the effect of predominantly anaerobic exercise in reducing obesity and inflammatory condition is still little known.Objectives: To assess the effects of aerobic vs. anaerobic training on the levels of C-reactive protein (CRP) in women with centralobesity, and the association of CRP levels with body composition. Methods: Randomized clinical trial with a population composed of adult, sedentary women with central obesity, enrolled at the Teaching-Care Outpatient Facility of Escola Bahiana de Medicina e Saúde Pública. A group of 19 women was randomly divided into two groups: Continuous training (CT - intensity at 20% of the ventilatory threshold - VT) or Interval Training (IT - 2-minute stimulus at 120% of VT and 2-minute recovery at 80% of VT) for 10 weeks, twice a week, 20-40-minute sessions. A medical and physical, laboratory and cardiopulmonary assessment was carried out before and after the intervention. Results: Median CRP levels were, respectively, before and after training: CT: 2.2mg/L (0.6-4.1mg/L) vs. 2.1mg/L (0.8-5.5mg/L)p=0.75; IT: 3.9mg/L (0.7-8.6mg/L) vs. 3.2mg/L (1.2-5.7mg/L) p=0.90. There was no significant difference when comparing the delta (Δ) CRP levels between groups, p=0.49. There was no association between CRP levels and other pre-intervention variables. Conclusion: Low-volume exercise programs, regardless of their intensity, do not change CRP levels in women with central obesity...


Subject(s)
Humans , Female , Adult , Exercise , Obesity, Abdominal/complications , C-Reactive Protein/analysis , Women , Age Factors , Anthropometry/methods , Body Mass Index , Waist Circumference/physiology , Randomized Controlled Trials as Topic , Statistical Analysis
16.
Int. j. cardiovasc. sci. (Impr.) ; 28(3): 189-199, mai.-jun. 2015. tab
Article in Portuguese | LILACS (Americas) | ID: lil-775241

ABSTRACT

Fundamentos: Dados mostram que a síndrome metabólica (SM) aumenta o risco de doença cardiovascular. Objetivos: Descrever e comparar as alterações cintilográficas e o valor preditivo de isquemia miocárdica emindivíduos com e sem SM, encaminhados para tomografia computadorizada de emissão de fóton único (SPECT)em Hospital Universitário utilizando três critérios diagnósticos de SM.Métodos: Estudo prospectivo observacional de pacientes encaminhados para SPECT de junho a dezembro 2010.Altura, peso e circunferência da cintura foram medidos. Levantamento de fatores de risco e revisão de prontuáriosmédicos foi realizado em busca de parâmetros para diagnóstico laboratorial de SM e relatórios completos deSPECT. Resultados: Foram incluídos 203 pacientes; 138 mulheres (68,0%); média de idade 63,6±11,5 anos. Apresentaram SM, 135 pacientes (66,5%). Entre os 99 exames alterados, 91,9% (n=91) ocorreram em pacientes com SM e 8,1%(n=8) em pacientes sem SM. Houve associação significativa entre a SM e a cintilografia anormal (67,0% vs. 11,8%;p<0,001) e os pacientes com SM tinham anormalidades de maior extensão e gravidade (escore de estresse somado(SSS)=7,3±6,5 vs. 3,0±0,9; p<0,001 e escore de diferença somado (SDS)=3,4±4,3 vs. 0,9±2,5; p<0,001). SM foi preditorindependente de isquemia miocárdica nas três definições estudadas (OR=10,07, 6,25 e 4,26 para NCEP-ATP IIImodificado, NCEP-ATP III e IDF, respectivamente). Conclusões: Pacientes com SM apresentaram mais defeitos de perfusão na SPECT (tanto fixa e reversível); e SMdefinida pelo NCEP-ATP III modificado foi o melhor preditor independente de isquemia miocárdica na cintilografia.


Background: Data show that metabolic syndrome (MS) increases the risk of cardiovascular disease.Objectives: To describe and compare the scintigraphic abnormalities and the predictive value of myocardial ischemia in individuals withand without MS referred for single photon emission computed tomography (SPECT) in a University Hospital using three diagnostic criteria.Methods: Prospective observational study of patients referred for SPECT from June to December 2010. Height, weight and waistcircumference were measured. Risk factors were assessed and medical records were reviewed to look for parameters for laboratorydiagnosis of MS and complete SPECT reports.Results: The study included 203 patients; 138 women (68.0%); mean age 63.6±11.5 years. Metabolic syndrome was found in135 patients (66.5%). Of the 99 abnormal tests, 91.9% (n=91) occurred in patients with MS and 8.1% (n=8) in patients withoutMS. There was a significant association between MS and abnormal scintigraphy (67.0% vs. 11.8%; p<0.001) and patients withMS had abnormalities of greater extent and severity (summed stress score (SSS)=7.3±6.5 vs. 3.0±0.9; p<0.001 and summed differencescore (SDS)=3.4±4.3 vs. 0.9±2.5; p<0.001). MS was an independent predictor of myocardial ischemia in the three definitions studied(OR=10.07, 6.25 and 4.26 for modified NCEP-ATP III, NCEP-ATP III and IDF, respectively).Conclusions: Patients with MS had more perfusion defects on SPECT (both fixed and reversible); and MS defined by the modifiedNCEP-ATP III was the best independent predictor of myocardial ischemia on scintigraphy.


Subject(s)
Humans , Male , Female , Aged , Cardiovascular Diseases/mortality , Risk Factors , Metabolic Syndrome/complications , Metabolic Syndrome/epidemiology , Tomography, Emission-Computed, Single-Photon/methods , Body Mass Index , Brazil/epidemiology , Diabetes Mellitus/diagnosis , United States/epidemiology , Hypertension/complications , Obesity, Abdominal/complications , Obesity/complications , Predictive Value of Tests , Prospective Studies
17.
Article in English | IMSEAR (South-East Asia), GHL | ID: sea-159280

ABSTRACT

Aim : To study the co-relation between pre-hypertension and abdominal obesity, dyslipidemia and glycemic status in young adults of a medical university. Objective : 1) To study the prevalence of pre-hypertension among the young adults of a medical university. 2) To co-relate prehypertension with other factors such as abdominal obesity, dyslipidemia and glycemic status. Methods : This study was conducted in Acharya Vinoba Bhave Rural Hospital, JN Medical College, Wardha .The students of Jawaharlal Nehru College were the participants for this study. Each participant was examined only after the undertaking of their informed consent. Students who fulfilled the criteria of prehypertensives as per the criteria of JNC, 7 where included in this study. A total of 55 students who were prehypertensive were included in the study. These 55 participants where further examined for anthropometric parameters like height, weight, body mass index (BMI) and waist hip ratio (WHR). For statistical analysis Chi - Square statistic method was employed. Results : The study showed that the prevalence of pre-hypertension was quite high (75%). There was a strong co-relation of pre-hypertension with BMI and WHR, and pre-hypertension was more prevalent in males as compared to females (49.8% versus 46.7%). Conclusion :Medical students are advised to adopt lifestyle changes to prevent the risk of future cardiovascular morbidity.


Subject(s)
Academic Medical Centers , Adolescent , Adult , Body Mass Index , Dyslipidemias/complications , Dyslipidemias/epidemiology , Female , Glycemic Index , Humans , India/epidemiology , Male , Obesity, Abdominal/complications , Obesity, Abdominal/epidemiology , Prehypertension/epidemiology , Prehypertension/etiology , Prehypertension/statistics & numerical data , Waist-Hip Ratio , Young Adult
18.
Arq. gastroenterol ; 52(1): 37-45, Jan-Mar/2015. tab
Article in English | LILACS (Americas) | ID: lil-746475

ABSTRACT

Background Evidence suggests a nutritional transition process in patients with inflammatory bowel disease. Obesity, which was once an uncommon occurrence in such patients, has grown in this population at the same prevalence rate as that found in the general population, bringing with it an increased risk of cardiovascular disease. Objective The aim of the present study was to determine the nutritional status and occurrence of cardiovascular risk factors in patients with inflammatory bowel disease. Methods A case-series cross-sectional study was conducted involving male and female adult outpatients with inflammatory bowel disease. Data were collected on demographic, socioeconomic, clinical and anthropometric variables as well as the following cardiovascular risk factors: sedentary lifestyle, excess weight, abdominal obesity, medications in use, comorbidities, alcohol intake and smoking habits. The significance level for all statistical tests was set to 5% (P< 0.05). Results The sample comprised 80 patients with inflammatory bowel disease, 56 of whom (70.0%) had ulcerative colitis and 24 of whom (30.0%) had Crohn's disease. Mean age was 40.3±11 years and the female genre accounted for 66.2% of the sample. High frequencies of excess weight (48.8%) and abdominal obesity (52.5%) were identified based on the body mass index and waist circumference, respectively, in both groups, especially among those with ulcerative colitis. Muscle depletion was found in 52.5% of the sample based on arm muscle circumference, with greater depletion among patients with Crohn’s disease (P=0.008). The most frequent risk factors for cardiovascular disease were a sedentary lifestyle (83.8%), abdominal obesity (52.5%) and excess weight (48.8%). Conclusion The results of the complete anthropometric evaluation draw one’s attention to a nutritional paradox, with high frequencies of both - muscle depletion, as well as excess weight and abdominal obesity. .


Contexto Evidências sugerem um processo de transição nutricional nos pacientes com doenças inflamatórias intestinais. A obesidade, que era um distúrbio incomum nas doenças inflamatórias intestinais, cresce em paralelo com a prevalência da obesidade em toda a população, podendo aumentar o risco de doenças cardiovasculares nesta população. Objetivo Avaliar o estado nutricional e a ocorrência de fatores de risco cardiovascular em pacientes com doenças inflamatórias intestinais. Métodos Métodos – Estudo transversal, série de casos, realizado em pacientes ambulatoriais com doenças inflamatórias intestinais, adultos e de ambos os sexos. Foram obtidas variáveis demográficas, socioeconômicas, clínicas, antropométricas e os fatores de risco cardiovascular: sedentarismo, excesso de peso, obesidade abdominal, medicamentos, comorbidades, alcoolismo e tabagismo. O nível de significância foi de 5,0%. Resultados A amostra foi constituída por 80 pacientes com doenças inflamatórias intestinais, 56 (70,0%) com etocolite ulcerativa inespecífica e 24 (30,0%) com doença de Crohn, sendo a idade média 40,3±11 anos e 66,2% do sexo feminino. Elevadas frequências de excesso de peso (48,8%) e obesidade abdominal (52,5%) foram identificadas, segundo o índice de massa corporal e a circunferência da cintura, respectivamente, em ambos os grupos, e de forma mais importante na retocolite ulcerativa inespecífica. A depleção de massa muscular ocorreu em 52,5% dos pacientes segundo a circunferência muscular do braço, sendo mais depletados aqueles com (P=0,008). Dentre os fatores de risco para doenças cardiovasculares, os mais frequentes foram o sedentarismo (83,8%), o perímetro abdominal elevado (52,5%) e o excesso de peso (48,8%). Conclusão A avaliação antropométrica completa mostrou elevada frequência de déficit proteico somático ao mesmo tempo em que se encontraram elevadas frequências de excesso de peso e obesidade abdominal. .


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Cardiovascular Diseases/etiology , Inflammatory Bowel Diseases/complications , Nutritional Status , Overweight/complications , Sarcopenia/etiology , Anthropometry , Cross-Sectional Studies , Outpatients , Obesity, Abdominal/complications , Risk Factors , Socioeconomic Factors
19.
Int. j. cardiovasc. sci. (Impr.) ; 28(1): 78-86, jan.-fev. 2015. ilus
Article in English, Portuguese | LILACS (Americas) | ID: lil-762192

ABSTRACT

O método osleriano, baseado na análise individual dos componentes funcionais de um organismo, vem apresentandosinais de esgotamento na tentativa de explicar a fisiopatologia de síndromes complexas como o câncer e as doençascardiovasculares. Por essa razão, vem sendo substituído progressivamente por um novo paradigma: a metodologia dossistemas biológicos. Esse novo modelo busca integrar conhecimentos de diferentes e modernas áreas de pesquisa como as ciências ômicas e a bioinformática, com o objetivo de desenvolver redes biológicas capazes de auxiliar no melhor entendimento dessas síndromes complexas. O objetivo dessa revisão é apresentar ao cardiologista clínico e ao investigador cardiovascular uma nova ferramenta denominada biologia de sistemas e a forma com que ela integra os dados provenientes das ciências ômicas, além de sua contribuição na nova abordagem das doenças cardiovasculares. Foirealizada pesquisa na base de dados Medline, dos principais artigos, até o presente momento, referentes ao cruzamento das palavras-chave em português e em inglês: “biologia de sistemas”, “insuficiência cardíaca”, “síndrome metabólica” e“arritmias cardíacas”; “systems biology”, “heart failure”, “metabolic syndrome” and “cardiac arrhythmias”. Concluiu-se que a biologia de sistemas deverá ser mais empregada para o melhor entendimento de doenças cardiovasculares complexas, como síndrome metabólica, aterosclerose, hipertensão arterial, insuficiência cardíaca e arritmias cardíacas. Cardiologistas, investigadores cardiovasculares, outros profissionais da saúde e pesquisadores da área básica de diferentes campos do conhecimento estarão mais integrados, buscando identificar modelos de redes aplicados à saúde e à doença, aquilo que hoje se denomina medicina em rede.


Based on individual analyses of the functional components of an organism, the oslerian method shows signs of depletion when attempting to explain the pathophysiology of complex syndromes such as cancer and cardiovascular diseases. This is why it isgradually being supplanted by a new paradigm: the methodology of biological systems. This new model strives to integrate knowledge in different modern research areas with the omics sciences and bioinformatics, in order to develop biological networks leading to abetter understanding of these complex syndromes. The purpose of this review is to introduce clinical cardiologists and cardiovascular researchers a new tool called systems biology, showing how it integrates data from the omics sciences and its contribution to a new approach to cardiovascular disease. To date, a search of the Medline database has been conducted with the following key words inPortuguese and English: “biologia de sistemas”, “insuficiência cardíaca”, “síndrome metabólica” e “arritmias cardíacas”; “systemsbiology”, “heart failure”, “metabolic syndrome” and “cardiac arrhythmias”. This led to the conclusion that systems biology must be used to an increasing extent for a better understanding of complex cardiovascular diseases such as metabolic syndrome, atherosclerosis, hypertension, heart failure and cardiac arrhythmias. Cardiologists, cardiovascular researchers, other healthcare practitioners and basic researchers in other fields of knowledge will build up closer links in a quest to identify health and disease network models that are now called network medicine.


Subject(s)
Humans , Young Adult , Middle Aged , Aged, 80 and over , Systems Biology/methods , Cardiovascular Diseases/physiopathology , MicroRNAs/metabolism , Diabetes Mellitus , Coronary Artery Disease/physiopathology , Atrial Fibrillation/physiopathology , Obesity, Abdominal/complications , Obesity, Abdominal/physiopathology , Phenotype , Metabolic Syndrome/diagnosis
20.
Rev. saúde pública ; 4927/02/2015. tab, graf
Article in English | LILACS (Americas), BBO | ID: biblio-909636

ABSTRACT

OBJECTIVE To analyze if differences according to gender exists in the association between tooth loss and obesity among older adults. METHODS We analyzed data on 1,704 older adults (60 years and over) from the baseline of a prospective cohort study conducted in Florianopolis, SC, Southern Brazil. Multivariable logistic regression models were used to assess the association between tooth loss and general and central obesity after adjustment for confounders (age, gender, skin color, educational attainment, income, smoking, physical activity, use of dentures, hypertension, and diabetes). Linear regressions were also assessed with body mass index and waist circumference as continuous outcomes. Interaction between gender and tooth loss was further assessed. RESULTS Overall mean body mass index was 28.0 kg/m2. Mean waist circumference was 96.8 cm for males and 92.6 cm for females. Increasing tooth loss was positively associated with increased body mass index and waist circumference after adjustment for confounders. Edentates had 1.4 (95%CI 1.1;1.9) times higher odds of being centrally obese than individuals with a higher number of teeth; however, the association lost significance after adjustment for confounders. In comparison with edentate males, edentate females presented a twofold higher adjusted prevalence of general and central obesity. In the joint effects model, edentate females had a 3.8 (95%CI 2.2;6.6) times higher odds to be centrally obese in comparison with males with more than 10 teeth present in both the arches. Similarly, females with less than 10 teeth in at least one arch had a 2.7 (95%CI 1.6;4.4) times higher odds ratio of having central obesity in comparison with males with more than 10 teeth present in both the arches. CONCLUSIONS Central obesity was more prevalent than general obesity among the older adults. We did not observe any association between general obesity and tooth loss. The association between central obesity and tooth loss depends on gender ­ females with tooth loss had greater probability of being obese.(AU)


OBJETIVO Analisar se há diferenças entre gêneros na associação entre obesidade e perda dentária em idosos. MÉTODOS Foram avaliados dados de 1.704 idosos (60 anos ou mais) da linha de base de um estudo de coorte prospectivo realizado em Florianópolis, SC. Modelos de regressão logística multivariáveis foram realizados para aferição da associação entre perda dentária e obesidade geral e central, ajustados por variáveis de confusão (idade, gênero, cor da pele, educação, renda, tabagismo, atividade física, uso de prótese dentária, hipertensão e diabetes). Na regressão linear, índice de massa corporal e circunferência da cintura foram tratados como variáveis contínuas. Foi avaliada também a interação entre gênero e perda dentária. RESULTADOS A média geral do índice de massa corporal foi 28,0. A média de circunferência da cintura foi de 96,8 cm para homens e 92,6 cm para mulheres. O aumento da perda dentária associou-se positivamente com o aumento do índice de massa corporal e da circunferência da cintura, após ajuste por variáveis de confusão. Edêntulos apresentaram chance 1,4 (IC95% 1,1;1,9) vez maior de apresentarem obesidade central quando comparados com aqueles com maior número de dentes presentes; entretanto, a associação perdeu significância estatística após o ajuste pelas variáveis de confusão. Comparadas com homens edêntulos, mulheres edêntulas apresentaram prevalência ajustada de obesidade geral e central duas vezes maior. No modelo de efeitos conjuntos, mulheres edêntulas tiveram uma razão de chances 3,8 (IC95% 2,2;6,6) vezes maior de apresentarem obesidade central, quando comparadas com homens com mais de 10 dentes presentes em ambas as arcadas. De maneira similar, mulheres com menos de 10 dentes presentes em pelo menos uma arcada tiveram uma razão de chances 2,7 (IC95% 1,6;4,4) vezes maior de terem obesidade central quando comparadas com homens com mais de 10 dentes presentes em ambas arcadas. CONCLUSÕES Obesidade central foi mais prevalente que obesidade geral em idosos. Não foram encontradas associações entre obesidade geral e perda dentária. Associação entre obesidade central e perda dentária depende do gênero ­ mulheres com perdas dentárias apresentaram maior probabilidade de serem obesas.(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Obesity/complications , Sex Factors , Tooth Loss/complications , Body Mass Index , Brazil/epidemiology , Cross-Sectional Studies , Obesity, Abdominal/complications , Obesity, Abdominal/epidemiology , Obesity/epidemiology , Prevalence , Prospective Studies , Socioeconomic Factors , Tooth Loss/epidemiology , Waist Circumference
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