Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 432
Filter
1.
Arch. latinoam. nutr ; 71(4): 281-289, dic. 2021. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1355216

ABSTRACT

Conocer la asociación específica de las enfermedades metabólicas en la mortalidad por COVID-19, ocurrida en México durante el año crítico de la pandemia de marzo 2020 a marzo 2021. Método. Se utilizó la base nacional de COVID-19 de la Dirección General de Epidemiología. Se analizaron los casos positivos que presentaron las enfermedades metabólicas: cardiovasculares, hipertensión, diabetes y obesidad. Se realizó un análisis descriptivo para conocer la distribución de los casos fallecidos y no fallecidos. Se empleó la prueba de ji cuadrada para la diferencia de las proporciones. Se utilizaron análisis de regresión logística para conocer la asociación entre las enfermedades metabólicas y la mortalidad por COVID-19 en personas positivas al virus SARS-CoV-2. Los datos fueron ajustados por edad y sexo. Resultados. Se observó la asociación de las enfermedades metabólicas en la mortalidad. La diabetes tuvo mayor porcentaje de letalidad 18,4%. Cuando se conjuntaron las enfermedades cardiovasculares y diabetes el porcentaje de letalidad subió a 31,5%; la conjunción de las enfermedades cardiovasculares, con hipertensión y diabetes fue la de mayor porcentaje de letalidad 38,7%. La obesidad fue la que tuvo menor incidencia. Conclusiones. Las enfermedades metabólicas en México son un problema de salud pública que afectó la mortalidad por covid-19. Es prioritario atender con políticas públicas preventivas y efectivas en favor de un modelo de consumo alimentario sano, acorde con las necesidades nutrimentales de la población(AU)


To know the specific association of metabolic disease on COVID-19 mortality, occurred during the critical year of the pandemic, from march 2020 to march 2021. Method: The Covid-19 national base of the General Directorate of Epidemiology was used. Positive cases of metabolic diseases were analyzed: cardiovascular disease, hypertension, diabetes and obesity. A descriptive analysis was carried out to find out the distribution of deceased and non-deceased cases. The chi-square test was used for the difference in proportions. Logistic regression analysis was used to understand the association between metabolic diseases and COVID 19 mortality in people who tested positive for the SARS-CoV-2 virus. The data were adjusted for age and gender. Results: The association of metabolic diseases on mortality was observed. Diabetes had a higher percentage of lethality 18,4%. When cardiovascular disease and diabetes were combined, the fatality rate rose to 31,5%; the combination of cardiovascular diseases, with hypertension and diabetes was the highest percentage of lethality 38,7%. Obesity had the least incidence. Conclusions: Metabolic diseases in México are a public health problem that affected COVID-19 mortality. It is a priority to deal with preventive and effective public policies in favor of a healthy food consumption model, in line with the nutritional needs of the population(AU)


Subject(s)
Humans , Male , Female , Cardiovascular Diseases/etiology , Diabetes Mellitus , Eating , COVID-19/mortality , Metabolic Diseases/complications , Metabolic Diseases/mortality , Obesity/physiopathology , Dietary Fats, Unsaturated , Epidemiology , Industrialized Foods , Pandemics , Hypertension
2.
Rev. cuba. endocrinol ; 32(1): e267, 2021.
Article in Spanish | LILACS, CUMED | ID: biblio-1289391

ABSTRACT

Introducción: La estrecha relación que existe entre diabetes mellitus tipo 2 y obesidad ha dado lugar a la creación del término "diabesidad", considerándose la nueva enfermedad del siglo XXI. La dupla entre estas produce grave lesión en el tejido hepático, músculo esquelético y sistema cardiovascular. Es importante un estilo de vida saludable y buena adherencia farmacológica para combatir esta pandemia. Objetivo: Describir aspectos generales acerca de la fisiopatología y el tratamiento de la diabesidad. Método: Se realizó una búsqueda bibliográfica no sistemática en las bases de datos Science Direct, EMBASE, LILACS, Redalyc, SciELO y PubMed. Los criterios de inclusión fueron publicaciones en inglés y español, en las que el título, palabras clave o resumen incluyen información pertinente al objetivo de estudio, periodicidad no mayor de cinco años. En la búsqueda se obtuvieron 50 artículos, de los cuales fueron seleccionados 35. Conclusión: La insulinorresistencia es el factor determinante para la progresión hacia diabetes mellitus tipo 2, en calidad de respuesta del tejido adiposo frente a altos niveles de ácidos grasos libres (lipotoxicidad), consecuencia de la obesidad, obligando al páncreas a secretar grandes cantidades de insulina, que con el tiempo compromete su funcionalidad. En la actualidad, existen diversas alternativas no farmacológicas, farmacológicas y quirúrgicas para el abordaje de la diabesidad, donde la prevención representa un aspecto de vital importancia(AU)


Introduction: The close relation among diabetes mellitus type 2 and obesity has led to the creation of the term "diabesity," considering it the new disease of XXI century. The fusion of these two diseases produces severe lesions in the hepatic tissue, the skeletal muscle and the cardiovascular system. It is important a healthy lifestyle and a good pharmacological adherence to fight this so called pandemic. Objective: Describe general aspects related to the physiopathology and treatment of diabesity. Method: It was carried out a non-systematic bibliographic search in databases like Science Direct, EMBASE, LILACS, Redalyc, SciELO and PubMed. The inclusion criteria were publications in English and Spanish language, with a periodicity of no more than 5 years, in which the title, keywords and abstract included information that will be relevant for the objective of the study. In the search 50 articles were found, of which 35 were selected. Conclusions: Insulin resistance is the key factor for the progression towards diabetes mellitus type 2, as a response of the adipose tissue to high levels of free fatty acids (lipotoxicity), which is a consequence of obesity, and obligates the pancreas to secrete big amounts of insulin that as time goes by compromises its functionality. Nowadays, there are different non-pharmacological, pharmacological and surgical alternatives to address the diabesity, in which prevention represents an aspect of vital importance(AU)


Subject(s)
Humans , Insulin Resistance , Diabetes Mellitus, Type 2/physiopathology , Healthy Lifestyle , Obesity/physiopathology , Review Literature as Topic , Databases, Bibliographic , Diabetes Mellitus, Type 2/therapy , Obesity/therapy
3.
Arch. cardiol. Méx ; 91(1): 7-16, ene.-mar. 2021. tab
Article in Spanish | LILACS | ID: biblio-1152855

ABSTRACT

Resumen Introducción: Las alteraciones del intercambio gaseoso se han reconocido en la obesidad mórbida; sin embargo, no se conoce su comportamiento conforme se incrementa el índice de masa corporal. Objetivo: Conocer el comportamiento del intercambio gaseoso a la altura de la Ciudad de México en el desarrollo de obesidad mórbida. Métodos: Mediante un diseño transversal analítico se estudió a sujetos pareados por género y edad de cuatro grupos diferentes de índice de masa corporal (kg/m2): normal (18.5-24.9), sobrepeso (25-29.9), obesidad (30-39.9) y obesidad mórbida (≥ 40). Se obtuvieron sus antecedentes patológicos y demográficos, variables de gasometría arterial y espirometría simple. Las variables se determinaron de acuerdo con las características de la muestra; las diferencias entre grupos se realizaron mediante Anova de una vía con ajuste de Bonferroni, así como la correlación de Pearson para las variables relacionadas. Una p < 0.05 se consideró con significación estadística. Resultados: Se estudió a 560 pacientes en cuatro grupos. La edad promedio fue de 49 ± 11 años. La mayor frecuencia de diabetes mellitus (34.29%), hipertensión arterial (50%) e hiperlipidemia (36.43%) se registró en el grupo de obesidad, y la de roncador (73.57%) en la obesidad mórbida. Se identificaron diferencias desde el grupo normal respecto de la obesidad mórbida: PaCO2 31.37 ± 2.08 vs. 38.14 ± 5.10 mmHg; PaO2 68.28 ± 6.06 vs. 59.86 ± 9.28 mmHg y SaO2 93.51 ± 1.93 vs. 89.71 ± 5.37%, todas con p = 0.0001. Correlación IMC-PaCO2: 0.497, e IMC-PaO2: -0.365, p = 0.0001, respectivamente. Conclusiones: A la altitud de la Ciudad de México y con índice de masa corporal > 30 kg/m2, las variables relacionadas con el intercambio gaseoso y espirometría simple comienzan a deteriorarse; son evidentes con IMC > 40 kg/m2.


Abstract Introduction: Alterations of gas exchange have been recognized in morbid obesity, however, it is not known how their behavior would be as the body mass index increases. Objective: To know the behavior of gas exchange at the level of Mexico City in the development of morbid obesity. Methods: Through analytical design, subjects matched by gender and age were studied from four different groups of body mass index (kg/m2), normal (18.5-24.9), overweight (25-29.9), obesity (30-39.9) and morbid obesity (≥ 40). Their pathological and demographic antecedents, arterial blood gas and simple spirometry variables were obtained. The variables were shown according to their sample characteristic. The differences between groups were made using one way Anova with Bonferroni adjustment, as well as Pearson’s correlation for the related variables. Statistical significance was considered with p < 0.05. Results: 560 subjects were studied in 4 groups. The average age 49 ± 11 years old. The highest frequency of diabetes mellitus (34.29%), arterial hypertension (50%) and hiperlipidemia (36.43%) was in the obesity group, and being snoring (73.57%) in morbid obesity. There were differences from the normal group versus. morbid obesity: PaCO2 31.37 ± 2.08 versus. 38.14 ± 5.10 mmHg; PaO2 68.28 ± 6.06 versus. 59.86 ± 9.28 mmHg and SaO2 93.51 ± 1.93 versus. 89.71 ± 5.37%, all with p = 0.0001. The IMC-PaCO2 correlation: 0.497, and IMC-PaO2: −0.365, p = 0.0001 respectively. Conclusions: At the altitude of Mexico City and body mass index > 30 kg/m2 the variables related to gas exchange and simple spirometry begin to deteriorate; are evident with BMI > 40 kg/m2.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Body Mass Index , Pulmonary Gas Exchange , Altitude , Obesity/physiopathology , Urban Health , Cross-Sectional Studies , Mexico
4.
Rev. bras. ginecol. obstet ; 43(2): 107-112, Feb. 2021. tab
Article in English | LILACS | ID: biblio-1156093

ABSTRACT

Abstract Objective To evaluate the obstetric and sociodemographic characteristics of gestational diabetic women who maintained hyperglycemia in the postpartum period (6-12 weeks postpartum). Methods This is a longitudinal cohort study with women who have had gestational diabetes and/or macrosomic children between March 1st, 2016 and March 1st, 2017. Between 6 and 12 weeks after birth, women who had gestational diabetes collected fasting glycemia, glucose tolerance test, and glycated hemoglobin results. The data were collected from medical records and during an interview in the first postpartum consultation. A statistical analysis was performed using frequency, percentage, Chi- Squared test, Fisher exact test, Mann-Whitney test, and multivariate Poisson regression. The significance level adopted for the statistical tests was 5%. Results One hundred and twenty-two women were included. Most of the women were younger than 35 years old (70.5%), white, multiparous, and with no history of gestational diabetes. Thirteen percent of the participants developed persistent hyperglycemia. A univariate analysis showed that maternal age above 35 years, being overweight, having grade 1 obesity and weight gain under 5 kg was related to the persistence of hyperglycemia in the postpartum period. Conclusion Maternal age above 35 years, obesity and overweight, and the diagnosis of gestational diabetes in the first trimester of pregnancy are associated with hyperglycemia during the postpartum period.


Resumo Objetivo Avaliar características sociodemográficas e obstétricas de mulheres com diabetes gestacional que mantêm hiperglicemia no período pós-parto (6-12 semanas pós-parto). Métodos Este é um estudo longitudinal de coorte com mulheres com diagnóstico de diabetes gestacional e/ou macrossomia fetal entre 1° de março de 2016 a 1° de março de 2017. As mulheres coletaram glicemia de jejum, teste de tolerância a glicose e hemoglobina glicada entre 6 a 12 semanas pós-parto. Os dados foram coletados de prontuários médicos e durante entrevista na primeira consulta de revisão pós-parto. Uma análise estatística foi realizada através do cálculo de frequências, porcentagens, teste do qui-quadrado, teste exato de Fisher, teste de Mann-Whitney e regressão multivariada de Poisson. A significância estatística adotada foi de 5%. Resultados Cento e vinte e duas mulheres foram incluídas. A maioria delas tinha menos de 35 anos de idade (70,5%), eram brancas, multíparas, e não tinham história de diabetes gestacional. Treze por cento das participantes desenvolveu hiperglicemia persistente. A análise univariada mostrou que os fatores relacionados com a persistência de hiperglicemia no período pós-natal foram: idade materna acima de 35 anos, sobrepeso, obesidade grau 1 e ganho de peso abaixo de 5 quilos. A análisemultivariada incluiu o diagnóstico no primeiro trimestre como fator de risco para hiperglicemia persistente. Conclusão Mulheres acima de 35 anos, obesidade, sobrepeso e diagnóstico de diabetes gestacional no primeiro trimestre estão relacionados com hiperglicemia persistente no período pós-parto.


Subject(s)
Humans , Female , Pregnancy , Adult , Young Adult , Puerperal Disorders/epidemiology , Diabetes, Gestational/physiopathology , Hyperglycemia/physiopathology , Obesity/physiopathology , Pregnancy Complications/physiopathology , Pregnancy Trimester, First , Puerperal Disorders/physiopathology , Puerperal Disorders/blood , Socioeconomic Factors , Blood Glucose , Brazil/epidemiology , Glycated Hemoglobin A , Cohort Studies , Longitudinal Studies , Hyperglycemia/blood
5.
Rev. chil. endocrinol. diabetes ; 14(3): 127-132, 2021. ilus
Article in Spanish | LILACS | ID: biblio-1293388

ABSTRACT

La obesidad es una enfermedad que se ha visto relacionada con la pandemia del nuevo coronavirus, sugiriendo que los obesos tienen mayor riesgo a padecer COVID-19 grave y sus complicaciones, cobrando mayor relevancia en Chile, país con tasas elevadas de obesidad. Se revisan mecanismos fisiopatológicos involucrados, efecto de las comorbilidades, posibilidad de atención médica y resultados de una eventual vacunación, corroborando un peor pronóstico para este grupo de pacientes. Se destaca la necesidad de datos antropométricos específicos, además del índice de masa corporal (IMC) para establecer una relación más relevante. La paradoja de la obesidad, de igual manera, carece de evidencias para asociarse al COVID-19.


Obesity is a disease that has been related to the new coronavirus pandemic, suggesting that obese people have a greater risk of suffering from severe COVID-19 and its complications, becoming more relevant in Chile, a country with high rates of obesity. The pathophysiological mechanisms involved, effect of comorbidities, medical care atention and potential vaccination, outcomes are reviewed, showing a worse prognosis for this group of patients. The need for specific anthropometric data is highlighted, in addition to the body mass index (BMI) to establish a more relevant relationship. Likewise, the obesity paradox, lacks of evidence to be associated with COVID-19.


Subject(s)
Humans , COVID-19/epidemiology , Obesity/epidemiology , Chile/epidemiology , Risk Factors , COVID-19/complications , COVID-19/physiopathology , Hospitalization , Obesity/complications , Obesity/physiopathology
6.
Rev. Hosp. Clin. Univ. Chile ; 32(1): 69-77, 2021.
Article in Spanish | LILACS | ID: biblio-1151925

ABSTRACT

Introduction: Obesity is a growing global health problem; it may even be one of the worst public health issues. In Chile, 34.4% of the population is obese, therefore, is it important for clinicians to be aware of all the consequences of obesity. In this review, we will address the relation of four main dermatologic conditions with obesity: psoriasis, hidradenitis suppurativa, acanthosis nigricans and malignant melanoma. Material and methods: Search in pubmed for obesity and psoriasis, hidradenitis suppurativa, acanthosis nigricans and malignant melanoma. Results: Obesity has a direct impact in the prevalence and severity of psoriasis, hidradenitis suppurativa, acanthosis nigricans. The reduction on body weight has proven to reduce severity of psoriasis and hidradenitis suppurativa. Obese patients with psoriasis have a higher risk on adverse effects due to medication and less effectiveness of biological medications. Acanthosis nigricans is a clinical indicator of insulin resistance and a risk predictor for those with greater risk to develop diabetes in the future. The relationship between obesity and malignant melanoma is not clear and needs further research. Conclusion: Obesity is increasing, dermatologist will face this condition more frequently, it has a great impact over psoriasis, hidradenitis suppurativa, acanthosis nigricans and malignant melanoma, thus it should be considered in treatment decisions. (AU)


Subject(s)
Humans , Male , Female , Obesity/physiopathology , Psoriasis/physiopathology , Hidradenitis Suppurativa/physiopathology , Acanthosis Nigricans/physiopathology , Melanoma/physiopathology , Obesity/epidemiology
7.
Arch. latinoam. nutr ; 70(3): 164-173, sept. 2020. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1150984

ABSTRACT

La obesidad es un problema de salud pública. La comprensión de factores tanto emocionales como dietéticos relacionados a su desarrollo es fundamentales para abordar este problema. El objetivo del presente estudio fue analizar por sexo y edad la relación de la grasa corporal con la alimentación emocional (AE) y la calidad de la dieta (CD) en población universitaria. Se realizó un estudio transversal en el que participaron 367 estudiantes universitarios de medicina (65 % mujeres). El porcentaje de grasa se midió a través de bioimpedancia eléctrica. La alimentación emocional (AE) (emoción, familia, indiferencia, cultura y efecto del alimento) se obtuvo de la escala de AE y la calidad de la dieta (CD)a partir de índice de calidad de la dieta mexicana (ICMX) (suficiente, balanceada, completa, variada e inocua), mediante un cuestionario semicuantitativo de frecuencia de consumo de alimentos. Para identificar qué variables independientes explican el porcentaje de grasa corporal se utilizó la regresión lineal múltiple. Se encontraron diferencias estadísticamente significativas entre sexos, los hombres presentaron valores superiores a las mujeres en edad, peso, altura e IMC (kg/m2), mientras que las mujeres presentaron un mayor porcentaje de grasa corporal respecto a los hombres. La cultura (p=,001) y efecto del alimento (p=,006), factores de la AE, predijeron menor porcentaje de grasa corporal en hombres mayores de 20 años. Resulta necesario implementar programas de salud, que vayan encaminados a un consumo saludable de alimentos mediante actividades recreativas y con el acompañamiento de profesionales de la salud durante la universidad(AU)


Obesity is a public health problem. Understanding both emotional and dietary factors related to its development are essential to address this problem. The objective of this study was to analyze by sex and age the relationship of body fat with emotional eating (EE) and diet quality (DQ) in university population. A cross-sectional study was carried out in which 367 university medical students participated (65% women). Body fat percentage was measured through electrical bioimpedance. Emotional eating (EE) (emotion, family, indifference, culture and effect of food) was obtained from the EE scale and diet quality (DQ) from the Mexican Diet Quality Index (MDQI) (sufficient, balanced, complete, varied and innocuous), using a semi-quantitative food consumption frequency questionnaire. Multiple linear regression was used to identify which independent variables explain body fat percentage. Statistically significant differences were found between sexes, men had higher values than women in age, weight, height, and BMI (kg/m2), while women had a higher body fat percentage compared to men. Culture (p = .001) and effect of food (p = .006), factors of EE, predicted lower body fat percentage in men older than 20 years. It is necessary to implement health programs that are aimed at a healthy consumption of food through recreational activities and with the accompaniment of health professionals during university(AU)


Subject(s)
Humans , Male , Female , Adult , Food Quality , Body Mass Index , Affective Symptoms , Overweight , Body Fat Distribution , Feeding Behavior , Obesity/physiopathology , Universities , Cardiovascular Diseases , Public Health , Student Health
9.
Rev. bras. anestesiol ; 70(2): 90-96, Mar.-Apr. 2020. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1137168

ABSTRACT

Abstract Introduction and objectives: The association pneumoperitoneum and obesity in video laparoscopy can contribute to pulmonary complications, but has not been well defined in specific groups of obese individuals. We assessed the effects of pneumoperitoneum in respiratory mechanics in Grade I obese compared to non-obese. Methods: Prospective study including 20 patients submitted to video laparoscopic cholecystectomy, normal spirometry, divided into non-obese (BMI ≤ 25 kg.m-2) and obese (BMI > 30 kg.mg-2), excluding Grade II and III obese. We measured pulmonary ventilation mechanics data before pneumoperitoneum (baseline), and five, fifteen and thirty minutes after peritoneal insufflation, and fifteen minutes after disinflation (final). Results: Mean BMI of non-obese was 22.72 ± 1.43 kg.m-2 and of the obese 31.78 ± 1.09 kg.m-2, p < 0.01. Duration of anesthesia and of peritoneal insufflation was similar between groups. Baseline pulmonary compliance (Crs) of the obese (38.3 ± 8.3 mL.cm H2O-1) was lower than of the non-obese (47.4 ± 5.7 mL.cm H2O-1), p = 0.01. After insufflation, Crs decreased in both groups and remained even lower in the obese at all moments assessed (GLM p < 0.01). Respiratory system peak pressure and plateau pressure were higher in the obese, albeit variations were similar at moments analyzed (GLM p > 0.05). The same occurred with elastic pressure, higher in the obese at all times (GLM p = 0.04), and resistive pressure showed differences in variations between groups during pneumoperitoneum (GLM p = 0,05). Conclusions: Grade I obese presented more changes in pulmonary mechanics than the non-obese during video laparoscopies and the fact requires mechanical ventilation-related care.


Resumo Justificativa e objetivos: Em videolaparoscopias, a associação de pneumoperitônio e obesidade pode contribuir para complicações pulmonares, mas não está bem definida em grupos específicos de obesos. Avaliamos os efeitos do pneumoperitônio na mecânica respiratória dos obesos Grau I em comparação aos não obesos. Métodos: Estudo prospectivo envolvendo 20 pacientes submetidos à colecistectomia videolaparoscópica, com espirometria normal, separados em não-obesos (IMC ≤ 25 kg.m-2) e obesos (IMC > 30 kg.mg-2), excluídos obesos Grau II e III. Mensuramos dados da mecânica ventilatória pulmonar antes do pneumoperitônio basal, após cinco, quinze e trinta minutos da insuflação peritoneal e quinze minutos após a desinsuflação final. Resultados: O IMC médio dos não obesos foi de 22,72 ± 1,43 kg.m-2 e dos obesos 31,78 ± 1,09 kg.m-2, p < 0,01. A duração da anestesia e da insuflação peritoneal foram semelhantes entre os grupos. A complacência pulmonar (Crs) basal dos obesos (38,3 ± 8,3 mL.cm H2O-1) foi inferior aos não obesos (47,4 ± 5,7 mL.cm H2O-1), p = 0,01. Após a insuflação, a Crs diminuiu nos dois grupos e permaneceu ainda mais baixa nos obesos em todos os momentos avaliados (GLM p < 0,01). A pressão de pico e a pressão de platô do sistema respiratório foram mais elevadas nos obesos, mas apresentaram semelhantes variações nos momentos analisados (GLM p > 0,05). O mesmo ocorreu com a pressão elástica, mais elevada nos obesos em todos tempos (GLM p = 0,04), e a pressão resistiva apresentou diferenças nas variações entre os grupos durante o pneumoperitônio (GLM p = 0,05). Conclusão: Obesos Grau I apresentam maiores alterações na mecânica pulmonar que os não obesos em videolaparoscopias e este fato recomenda cuidados relacionados a ventilação mecânica.


Subject(s)
Humans , Female , Adult , Pneumoperitoneum, Artificial , Respiratory Mechanics , Cholecystectomy, Laparoscopic/methods , Video-Assisted Surgery , Obesity/physiopathology , Prospective Studies , Longitudinal Studies , Middle Aged
10.
Rev. Méd. Clín. Condes ; 31(2): 130-138, mar.-abr. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1223504

ABSTRACT

La depresión y la obesidad son patologías altamente prevalentes y corresponden a los principales problemas de salud pública. Estas patologías tienen un gran impacto en la morbilidad y mortalidad de los pacientes y afectan la salud y el bienestar de quienes las padecen, así como también afectan en el aspecto socioeconómico consecuencia del deterioro funcional y el gasto de recursos en salud ocasionados. Resultados de estudios epidemiológicos, ensayos clínicos y meta-análisis apoyan la asociación entre los estados depresivos y la obesidad, ya que ambos ocurren conjuntamente en todas las razas de poblaciones evaluadas. El objetivo es abordar la evidencia con respecto a 4 aspectos: (1) obesidad y respuesta a los antidepresivos, (2) trastornos depresivos y su impacto sobre la progresión de la obesidad, (3) tratamiento de la obesidad y el impacto sobre los resultados entre pacientes con trastornos depresivos, (4) el tratamiento de los trastornos depresivos y su impacto sobre los resultados de la obesidad. La evidencia existente apoya la asociación entre obesidad y los resultados adversos para la salud en individuos con trastornos depresivos. Además, destaca el concepto que el tratamiento de una de las dos enfermedades (obesidad o trastornos depresivos) es relevante para mejorar el curso de la otra patología. Puede ser beneficioso explorar dirigidamente la presencia de un trastorno depresivo en sujetos con sobrepeso u obesidad, así como el aumento de peso en personas con depresión. Conocer el efecto de los fármacos antidepresivos sobre el peso corporal es también relevante para facilitar la adherencia al tratamiento en el largo plazo.


Depression and obesity are highly prevalent illness and a mayor public health concern. These diseases have a great impact on morbidity and mortality of patients and affect the health and well-being of those who suffer them, as well as being affected in the socioeconomic aspect as a result of the functional deterioration and the spending of resources. Results of epidemiological studies, clinical trials and meta-analysis support the association between mood disorders and obesity, since both occur together in all the populations evaluated. The objective is to address the evidence regarding four aspects: (1) obesity and response to antidepressants, (2) depressive disorders and their effect on the progression of obesity, (3) treatment of obesity and the effect on outcomes among patients with depressive disorders, (4) the treatment of depressive disorders and their effect on obesity outcomes. Existing evidence supports the association between obesity and adverse health outcomes in individuals with depressive disorders. In addition, it highlights the concept that the treatment of one of the two diseases (obesity or depressive disorders) is relevant to improve the course of the other disease. It may be beneficial to explore the presence of a depressive disorders in overweight or obese subjects, as well as weight gain in subjects with depression. Knowing the effect of antidepressant drugs on body weight is relevant to facilitate adherence to long-term treatment.


Subject(s)
Humans , Depressive Disorder/psychology , Depressive Disorder/epidemiology , Obesity/psychology , Obesity/epidemiology , Body Weight , Body Mass Index , Depressive Disorder/physiopathology , Depressive Disorder/drug therapy , Overweight , Antidepressive Agents/therapeutic use , Obesity/physiopathology , Obesity/therapy
11.
Rev. chil. radiol ; 26(1): 17-24, mar. 2020.
Article in Spanish | LILACS | ID: biblio-1115521

ABSTRACT

Resumen: la obesidad constituye un problema mayor de salud pública relevante en la actualidad, considerando que cumple un doble rol al actuar como factor de riesgo para la mayoría de las enfermedades crónicas no transmisibles y constituir una entidad nosológica independiente. Los estudios de imágenes han contribuido, desde diferentes perspectivas, a dilucidar los mecanismos propios de la enfermedad, sus complicaciones, progresión, mecanismos cognitivos involucrados y respuesta a diversos esquemas terapéuticos. El objetivo del presente artículo es proveer de una visión general respecto a cómo los estudios imagenológicos, especialmente basados en resonancia magnética, han profundizado la comprensión de los mecanismos metabólicos y neurocognitivos, relacionados, así como elementos vinculados al tratamiento. Adicionalmente se discuten posibles direcciones futuras en este campo.


Abstract: Obesity constitutes a relevant issue in public health. It acts both like a risk factor for most of the non-communicable diseases and as an independent nosologic entity. The imaging studies have contributed, from several perspectives, to elucidate the underlying mechanisms of the disease. its complications, progression, involved cognitive phenomena and the response to different therapeutic approaches. The objective of this article is to provide a global view about how the imaging studies, particularly those based on magnetic resonance imaging, have given a deeper comprehension of the related metabolic and cognitive mechanisms and some facts related to the treatment. Additionally, future directions of this field are discussed.


Subject(s)
Humans , Obesity/diagnostic imaging , Magnetic Resonance Imaging , Obesity/physiopathology , Obesity/therapy
12.
Int. braz. j. urol ; 46(1): 5-14, Jan.-Feb. 2020. graf
Article in English | LILACS | ID: biblio-1056367

ABSTRACT

ABSTRACT The exact prevalence of pelvic organ prolapse is difficult to establish. The anatomical changes do not always consist with the severity or the symptoms associated with prolapse. There are many risk factors associated with pelvic organ prolapse and this review aims to identify the epidemiology and pathophysiology while looking at the known risk factors for pelvic organ prolapse. PubMed search involved a number of terms including: epidemiology, risk factors, reoccurrence indicators, management and evaluation. Several risk factors have been associated with pelvic organ prolapse, all contribute to weakening of the pelvic floor connective tissue/collagen, allowing the pelvic organs to prolapse through the vaginal walls. Among the risk factors are genetic background, childbirth and mode of delivery, previous hysterectomy, menopausal state and the ratio between Estrogen receptors. The "Integral theory" of Petros and the "Levels of Support" model of Delancey enable us to locate the defect, diagnose and treat pelvic organ prolapse. The currently available demographic data is not reliable enough to properly estimate the true extent of pelvic organ prolapse in the population. However, standardization of the diagnosis and treatment may significantly improve our ability to estimate the true incidence and prevalence of this condition in the coming years.


Subject(s)
Humans , Female , Pelvic Organ Prolapse/etiology , Pelvic Organ Prolapse/physiopathology , Parity , Menopause/physiology , Risk Factors , Collagen/physiology , Pelvic Floor/physiopathology , Pelvic Organ Prolapse/therapy , Obesity/complications , Obesity/physiopathology
13.
Salud bienestar colect ; 4(1): 33-43, ene.-abr. 2020. tab
Article in Spanish | LILACS | ID: biblio-1179914

ABSTRACT

IINTRODUCCIÓN: la hipertensión arteriales una entidad asintomática, cuyos factores de riesgo son el peso corporal, la dieta, el consumo de alcohol y tabaco, el sedentarismo, las dislipidemias, la hiperglicemia y la diabetes. La obesidad como consecuencia de la malnutrición por exceso es un importante problema de la salud pública en el mundo entero, ya que esto representa un alto costo económico y social para las personas y el Estado. Las dislipidemias son enfermedades metabólicas que cursan con concentraciones anormales de lípidos en la sangre, siendo un factor de riesgo para la presentación de enfermedades cardiovasculares. Es muy frecuente la relación entre estas entidades y la HTA. El objetivo del presente trabajo fue identificar la prevalencia de dislipidemias y obesidad y su relación con la presencia de hipertensión arterial en trabajadores universitarios en una región de Ecuador. MATERIAL Y MÉTODOS: la investigación fue observacional, descriptiva, cuantitativa, de corte transversal. Se seleccionaron 60 trabajadores, se tomaron muestras de sangre al igual que se registró su presión arterial. Con los datos de talla y peso se calculó el IMC para el estudio. Los datos se analizaron en SPSS. RESULTADOS: el 36,66% tuvo hipercolesterolemia, el 41,66% hipertrigliceridemia. El 55% tuvo cifras bajas de HDL, y el 18,33% tuvo cifras elevadas de LDL. El 20% presentó dislipidemia mixta. El 10% presentó obesidad, el 53,33% sobrepeso y el 36,66% peso normal. La prevalencia de hipertensión fue de apenas el 18,33%. Existe correlación entre la hipertensión y el consumo de alcohol, así como con los valores de LDL. CONCLUSIONES. Las prevalencias de obesidad, dislipidemias e hipertensión arterial en los trabajadores universitarios estudiados, son similares a las presentadas en la región, a excepción de la obesidad que registra una prevalencia baja. Las dislipidemias, a excepción de la Hiper LDL, no guardan correlación con la HTA.


INTRODUCTION: arterial hypertension is an asymptomatic entity, whose risk factors are body weight, diet, alcohol and tobacco consumption, sedentarism, dyslipidemias, hyperglycemia and diabetes. Obesity as a consequence of overnutrition is a major public health problem worldwide, as it represents a high economic and social cost for individuals and the State. Dyslipidemias are metabolic diseases with abnormal concentrations of lipids in the blood, and are a risk factor for cardiovascular disease. The relationship between these entities and ETS is very frequent. The aim of the present work was to identify the prevalence of dyslipidemias and obesity and its relation with the presence of arterial hypertension in university workers in a region of Ecuador. MATERIAL AND METHODS: the research was observational, descriptive, quantitative, and cross-sectional. Sixty workers were selected, blood samples were taken, and their blood pressure was recorded. With the data of height and weight the BMI was calculated for the study. The datawere analyzed in SPSS. Results: 36.66% had hypercholesterolemia, 41.66% hypertriglyceridemia. 55% had low HDL, and 18.33% had high LDL. 20% had mixed dyslipidemia. 10% presented obesity, 53.33% overweight and 36.66% normal weight. The prevalence of hypertension was only 18.33%. There is a correlation between hypertension and alcohol consumption, as well as with LDL values. CONCLUSIONS: the prevalence of obesity, dyslipidemias and hypertension in the university workers studied, are similar to those presented in the region, except for obesity which has a low prevalence. Dyslipidemias, with the exception of Hyper LDL, are not correlated with ETS.Keywords:dyslipidemias, overweight, obesity, hypertension, correlation.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Hypertension/etiology , Obesity/complications , Obesity/epidemiology , Body Mass Index , Prevalence , Clinical Laboratory Techniques , Ecuador/epidemiology , Dyslipidemias , Overweight , Correlation of Data , Obesity/physiopathology
14.
J. appl. oral sci ; 28: e20190694, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1134777

ABSTRACT

Abstract Objective Obesity is a chronic disease that negatively affects an individual's general and oral health. The present study aimed to compare the clinical and microbiological effects of non-surgical periodontal therapy with the full mouth disinfection (FMD) protocol on obese and non-obese individuals at 9 months post-therapy. Methodology This clinical study was first submitted and approved by the Ethics Committee. Fifty-five obese patients and 39 non-obese patients with periodontitis were evaluated. The full-mouth periodontal clinical parameters, clinical attachment level (CAL), probing depth (PD), gingival index (GI), and plaque index (PI), were monitored at baseline, 3, 6, and 9 months after periodontal treatment with full mouth disinfection (FMD) protocol. The mean count of Tannerella forsythia , Porphyromonas gingivalis , Treponema Denticola , and Aggregatibacter actinomycetemcomitans was determined by quantitative polymerase chain reaction on subgingival biofilm samples. Demographic data were assessed by Chi-square test. For clinical and microbiological parameters, two-factor repeated-measures ANOVA was used. Results In both groups, periodontal therapy using the one-stage full-mouth disinfection protocol significantly improved CAL, PD, GI, and PI (p<0.05). Obese and non-obese patients equally responded to non-surgical periodontal therapy (p>0.05). Microbial count found no major differences (p>0.05) between obese and non-obese individuals who had undergone non-surgical periodontal therapy. Conclusions Obesity did not affect the clinical and microbiological outcomes of non-surgical periodontal therapy.


Subject(s)
Humans , Male , Female , Adult , Periodontitis/microbiology , Periodontitis/therapy , Obesity/microbiology , Time Factors , Periodontal Index , Anthropometry , Dental Plaque Index , Prospective Studies , Risk Factors , Analysis of Variance , Longitudinal Studies , Treatment Outcome , Aggregatibacter actinomycetemcomitans/isolation & purification , Porphyromonas gingivalis/isolation & purification , Statistics, Nonparametric , Treponema denticola/isolation & purification , Tannerella forsythia/isolation & purification , Middle Aged , Obesity/physiopathology
15.
Article in English | LILACS, BBO | ID: biblio-1101870

ABSTRACT

ABSTRACT The coronavirus disease 2019 (covid-19) pandemic has caused a public health emergency worldwide. Risk, severity and mortality of the disease have been associated with non-communicable chronic diseases, such as diabetes mellitus. Accumulated evidence has caused great concern in countries with high prevalence of this morbidity, such as Brazil. This text shows the picture of diabetes in Brazil, followed by epidemiological data and explanatory hypothesis for the association between diabetes and covid-19. We emphasized how the burden of these two morbidities in a middle-income country has aggravated this pandemic scenario. The comprehension of this association and biological plausibility may help face this pandemic and future challenges.


Subject(s)
Humans , Male , Female , Adult , Aged , Aged, 80 and over , Pneumonia, Viral/epidemiology , Coronavirus Infections/epidemiology , Diabetes Complications/epidemiology , Diabetes Mellitus/epidemiology , Betacoronavirus , Pneumonia, Viral/physiopathology , Severity of Illness Index , Brazil/epidemiology , Cardiovascular Diseases/complications , Cardiovascular Diseases/physiopathology , Cardiovascular Diseases/epidemiology , Comorbidity , Prevalence , Risk Factors , Age Factors , Coronavirus Infections/physiopathology , Diabetes Complications/physiopathology , Diabetes Mellitus/physiopathology , Pandemics , SARS-CoV-2 , COVID-19 , Hypertension/complications , Hypertension/physiopathology , Hypertension/epidemiology , Middle Aged , Obesity/complications , Obesity/physiopathology , Obesity/epidemiology
16.
Einstein (Säo Paulo) ; 18: eAO5150, 2020. tab
Article in English | LILACS | ID: biblio-1090068

ABSTRACT

ABSTRACT Objective To verify the association of obesity and infertility related to anovulatory issues. Methods This case-control study was carried out with 52 women, aged 20 to 38 years, divided into two groups (infertile − cases − and fertile − control), seen at outpatient clinics, in the period from April to December, 2017. Results We found significant evidence that obesity negatively affects women's fertility (p=0.017). The group of infertile women was 7.5-fold more likely to be obese than fertile women. Conclusion Strategies that encourage weight control are indicated for women with chronic anovulation, due to hight metabolic activity of adipose tissue.


RESUMO Objetivo Verificar em mulheres a associação entre obesidade e infertilidade relacionada a questões anovulatórias. Métodos Estudo de caso-controle com 52 mulheres, de 20 a 38 anos, divididas em dois grupos (mulheres inférteis − casos − e férteis − controles), atendidas em ambulatórios, no período de abril a dezembro de 2017. Resultados Verificou-se evidência significativa de que a obesidade afeta negativamente na fertilidade das mulheres (p=0,017). O grupo de mulheres inférteis teve 7,5 vezes mais chances de serem obesas quando comparadas às mulheres férteis. Conclusão Estratégias que estimulem o controle do peso são indicadas para mulheres com anovulação crônica devido à elevada atividade metabólica do tecido adiposo.


Subject(s)
Humans , Female , Adult , Young Adult , Infertility, Female/etiology , Anovulation/etiology , Obesity/complications , Exercise/physiology , Case-Control Studies , Anthropometry , Surveys and Questionnaires , Risk Factors , Sedentary Behavior , Infertility, Female/physiopathology , Infertility, Female/metabolism , Anovulation/physiopathology , Anovulation/metabolism , Metabolic Diseases/complications , Metabolic Diseases/physiopathology , Obesity/physiopathology , Obesity/metabolism
17.
Einstein (Säo Paulo) ; 18: eAO4784, 2020. tab, graf
Article in English | LILACS | ID: biblio-1039736

ABSTRACT

ABSTRACT Objective To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity. Methods Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight mice each, as follows: standard diet + no training; standard diet + muscular resistance training; standard diet + hypertrophy training; standard diet + strength training; high-fat diet + no training; high-fat diet + muscular resistance training; high-fat diet + hypertrophy training; high-fat diet + strength training. The training protocol consisted of stair climbing for a 10-week period. Blood samples were collected for lactate analysis, glucose level measurement and insulin tolerance test. After euthanasia, adipose tissues were removed and weighed for adiposity index determination. Fragments of epididymal adipose tissue were then embedded for histological analysis or homogenized for tumor necrosis factor alpha level determination using the ELISA method. Results Ausency of differences in total training volume and blood lactate levels overall emphasize the similarity between the different resistance training protocols. Body weight loss, reduced adipocyte area and lower adiposity index were observed in trained obese mice, regardless of training modality. Different training protocols also improved insulin sensitivity and reduced inflammation levels. Conclusion Resistance training protocols were equally effective in reducing body fat, inflammation levels and insulin resistance in obese mice.


RESUMO Objetivo Avaliar os efeitos de três tipos de treinamentos de resistência na adiposidade, na inflamação e na ação da insulina em camundongos Swiss obesos por dieta hiperlipídica. Métodos Camundongos Swiss machos magros e obesos foram selecionados e posteriormente separados em oito grupos com oito animais em cada: dieta padrão + não treinado; dieta padrão + treinamento de resistência muscular; dieta padrão + treinamento de hipertrofia; dieta padrão + treinamento de força; dieta hiperlipídica + não treinado; dieta hiperlipídica + treinamento de resistência muscular; dieta hiperlipídica + treinamento de hipertrofia; e dieta hiperlipídica + treinamento de força. O protocolo de treinamento consistiu em escaladas, por um período de 10 semanas. Amostras de sangue foram coletadas para análises de lactato, glicemia e teste de tolerância à insulina. Após eutanásia, os tecidos adiposos foram retirados e pesados para determinar o índice de adiposidade. Em seguida, parte do tecido adiposo epididimal foi emblocado para análises histológicas, e outra parte foi homogeneizada para análises de fator de necrose tumoral alfa por ELISA. Resultados O volume total de treinamento e a concentração sanguínea de lactato não diferiram entre os três treinos resistidos, sugerindo similaridade entre eles. Nos animais obesos, as três modalidades de treinamento reduziram o peso corporal, a área adipocitária e o índice de adiposidade. Os três tipos de treinamentos ainda melhoraram a tolerância à insulina e reduziram a inflamação. Conclusão Os protocolos de treinamento resistido foram igualmente efetivos em reduzir a adiposidade, a inflamação e a resistência à ação da insulina em camundongos obesos.


Subject(s)
Animals , Male , Mice , Physical Conditioning, Animal/physiology , Insulin Resistance/physiology , Adiposity/physiology , Muscle Stretching Exercises/methods , Hypertrophy/physiopathology , Inflammation/physiopathology , Obesity/physiopathology , Time Factors , Blood Glucose/analysis , Body Weight/physiology , Enzyme-Linked Immunosorbent Assay , Reproducibility of Results , Tumor Necrosis Factor-alpha/analysis , Adipose Tissue, White/physiopathology , Resistance Training/methods , Diet, High-Fat , Mice , Mice, Obese
18.
Einstein (Säo Paulo) ; 18: eAO4876, 2020. tab, graf
Article in English | LILACS | ID: biblio-1039734

ABSTRACT

ABSTRACT Objective To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet. Methods Male C57Bl6 mice aged 9 weeks were allocated to one of two groups - Control and Obese, and fed a standard or high-fat diet for 10 weeks, respectively. Mice were then further subdivided into four groups with seven mice each, as follows: Control, Control-Sericin, Obese, and Obese-Sericin. The standard or high fat diet was given for 4 more weeks; sericin (1,000mg/kg body weight) was given orally to mice in the Control-Sericin and Obese-Sericin Groups during this period. Weight gain, food intake, fecal weight, fecal lipid content, gut motility and glucose tolerance were monitored. At the end of experimental period, plasma was collected for biochemical analysis. Samples of white adipose tissue, liver and jejunum were collected and processed for light microscopy analysis; liver fragments were used for lipid content determination. Results Obese mice experienced significantly greater weight gain and fat accumulation and had higher total cholesterol and glucose levels compared to controls. Retroperitoneal and periepididymal adipocyte hypertrophy, development of hepatic steatosis, increased cholesterol and triglyceride levels and morphometric changes in the jejunal wall were observed. Conclusion Physiological changes induced by obesity were not fully reverted by sericin; however, sericin treatment restored jejunal morphometry and increased lipid excretion in feces in obese mice, suggesting potential anti-obesity effects.


RESUMO Objetivo Investigar os efeitos da sericina extraída de casulos de Bombyx mori na morfofisiologia de camundongos com obesidade induzida por dieta hiperlipídica. Métodos Camundongos machos C57Bl6, com 9 semanas de idade, foram distribuídos em Grupos Controle e Obeso, que receberam ração padrão para roedores ou dieta hiperlipídica por 10 semanas, respectivamente. Posteriormente, os animais foram redistribuídos em quatro grupos, com sete animais cada: Controle, Controle-Sericina, Obeso e Obeso-Sericina. Os animais permaneceram recebendo ração padrão ou hiperlipídica por 4 semanas, período no qual a sericina foi administrada oralmente na dose de 1.000mg/kg de massa corporal aos Grupos Controle-Sericina e Obeso-Sericina. Parâmetros fisiológicos, como ganho de peso, consumo alimentar, peso das fezes em análise de lipídios fecais, motilidade intestinal e tolerância à glicose foram monitorados. Ao término do experimento, o plasma foi coletado para dosagens bioquímicas e fragmentos de tecido adiposo branco; fígado e jejuno foram processados para análises histológicas, e amostras hepáticas foram usadas para determinação lipídica. Resultados Camundongos obesos apresentaram ganho de peso e acúmulo de gordura significativamente maior que os controles, aumento do colesterol total e glicemia. Houve hipertrofia dos adipócitos retroperitoneais e periepididimais, instalação de esteatose e aumento do colesterol e triglicerídeos hepáticos, bem como alteração morfométrica da parede jejunal. Conclusão O tratamento com sericina não reverteu todas as alterações fisiológicas promovidas pela obesidade, mas restaurou a morfometria jejunal e aumentou a quantidade de lipídios eliminados nas fezes dos camundongos obesos, apresentando-se como potencial tratamento para a obesidade.


Subject(s)
Animals , Male , Anti-Obesity Agents/therapeutic use , Sericins/therapeutic use , Obesity/drug therapy , Time Factors , Triglycerides/analysis , Body Weight/drug effects , Gastrointestinal Transit/drug effects , Weight Gain/drug effects , Adipose Tissue/pathology , Cholesterol/analysis , Reproducibility of Results , Treatment Outcome , Anti-Obesity Agents/pharmacology , Sericins/pharmacology , Eating/drug effects , Fatty Liver/pathology , Diet, High-Fat/adverse effects , Glucose Tolerance Test , Liver/metabolism , Mice, Inbred C57BL , Mice, Obese , Obesity/etiology , Obesity/physiopathology
19.
Rev. bras. ginecol. obstet ; 41(11): 660-667, Nov. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057876

ABSTRACT

Abstract Objective The incidence of obesity, which is a chronic condition, has increased in recent years. The association between obesity and female sexual dysfunction remains unclear, particularly in postmenopausal women. In the present study, we evaluated whether obesity is a risk factor for sexual dysfunction in postmenopausal women. Methods This is a cross-sectional study that analyzed data from interviews of postmenopausal women at the Climacteric Outpatient Clinic from 2015 to 2018. After applying the inclusion and exclusion criteria, 221 women aged between 40 and 65 years old were selected and invited to participate in the study. Obesity was diagnosed according to body mass index (BMI). The participants were grouped into the following BMI categories: group 1, 18.5-24.9 kg/m2 (normal); group 2, 25.0- 29.9 kg/m2 (overweight); and group 3, ≥30.0 kg/m2 (obese). Sexual function was assessed using the Female Sexual Function Index (FSFI) questionnaire. Cutoff points of ≥23 and ≥26.5 were adopted to define a diagnosis of female sexual dysfunction (FSD) based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision by the American Psychiatric Association (DSM-IV-TR). Results The desire and arousal scores were statistically higher in the normal BMI group than in the obese group (p=0.028 and p=0.043, respectively). The satisfaction scores were statistically higher in the normal BMI group than in the overweight and obese groups (p<0.05). The total FSFI score statistically differed among the BMI categories (p=0.027). Conclusion In the present study, obese and overweight postmenopausal women had higher total scores than women with normal BMI. Our results show that obese and overweight postmenopausal women had a higher index of dysfunction in desire and arousal and lower sexual satisfaction than normal-weight women.


Resumo Objetivo A incidência de obesidade, que é uma condição crônica, aumentou nos últimos anos. A associação entre obesidade e disfunção sexual feminina ainda não está clara, particularmente emmulheres após amenopausa. No presente estudo, avaliamos se a obesidade é um fator de risco para disfunção sexual em mulheres após a menopausa. Métodos Este é umestudo transversal que analisou dados de entrevistas demulheres após a menopausa no Ambulatório de Climatério a partir de 2015 até 2018. Após a aplicação dos critérios de inclusão e exclusão, 221 mulheres com idade entre 40 e 65 anos foram selecionadas e convidadas a participar do estudo. Obesidade foi diagnosticada de acordo com o índice de massa corpórea (IMC). Os participantes foram agrupados nas seguintes categorias de IMC: grupo 1: 18,5-24,9 kg/m2 (normal); grupo 2: 25,0-29,9 kg/m2 (sobrepeso); e grupo 3: ≥30,0 kg/m2 (obesidade). A função sexual foi avaliada através do questionário Female Sexual Function Index (FSFI, na sigla em inglês). Pontos de corte de ≥23 e ≥26,5 foram adotados para definir um diagnóstico de disfunção sexual feminina (DSF) com base no Manual de Diagnóstico e Estatística das Perturbações Mentais, 4ª Edição, Texto Revisto DSM-IV-TR. Resultados Os escores de desejo e excitação foram estatisticamente maiores no grupo com IMC normal do que no grupo obesidade (p=0,028 e p=0,043, respectivamente). Os escores de satisfação foram estatisticamente maiores no grupo com IMC normal do que nos grupos comsobrepeso e obesidade (p<0,05). A pontuação total do FSFI diferiu estatisticamente entre as categorias de IMC (p=0,027). Conclusão No presente estudo,mulheres após a menopausa obesas e com sobrepeso tiveram escores totais mais altos do que mulheres com IMC normal. Nossos resultados mostram que mulheres obesas e com sobrepeso após a menopausa apresentaram índices mais altos de disfunção no desejo e excitação e menor satisfação sexual do que mulheres com peso normal.


Subject(s)
Humans , Female , Adult , Sexual Dysfunction, Physiological/epidemiology , Postmenopause/psychology , Sexual Dysfunctions, Psychological/epidemiology , Obesity/physiopathology , Obesity/psychology , Brazil/epidemiology , Body Mass Index , Cross-Sectional Studies , Risk Factors , Middle Aged
20.
J. pediatr. (Rio J.) ; 95(5): 575-583, Sept.-Oct. 2019. tab
Article in English | LILACS | ID: biblio-1040361

ABSTRACT

Abstract Objective: Evaluate the association between inflammatory process, adiposity, and vitamins A, D, and E in adolescents, according to gender. Methods: Cross-sectional study with adolescents aged 12-19 years old of both genders attending public schools in Recife. A questionnaire was used to collect data on socioeconomic level, lifestyle, and food intake of adolescents. Then, an anthropometric evaluation and a blood sampling were performed to analyze serum concentrations of α-1-acid glycoprotein, retinol, β-carotene, α-tocopherol, and 25-hydroxy-vitamin D. Results: The levels of α-1-acid glycoprotein were higher for abdominal obesity in both genders. Male adolescents with insufficient serum α-tocopherol levels had low levels of α-1-acid glycoprotein (p = 0.03) and an increased risk of 25-hydroxy-vitamin D and β-carotene deficiency in relation to total and abdominal fat; female adolescents had an increased risk of insufficient β-carotene with abdominal obesity (PR: 1.33; 95% CI: 1.2-1.5). Conclusion: Abdominal adiposity implies a higher risk of inflammation and causes different changes to the levels of fat-soluble vitamins according to gender.


Resumo: Objetivo: Avaliar a associação entre processo inflamatório, adiposidade e as vitaminas A, D e E em adolescentes, segundo o sexo. Métodos: Estudo transversal com adolescentes de 12 a 19 anos de ambos os sexos de escolas públicas de Recife. Foi utilizado um questionário para coleta de dados socioeconômicos, de estilo de vida e de consumo alimentar dos adolescentes. Em seguida, realizou-se a avalição antropométrica e coleta de sangue para análise das concentrações séricas de α-1-glicoproteína ácida, retinol, β-caroteno, α-tocoferol e 25-hidroxivitamina D. Resultados: Os níveis de α-1-glicoproteína ácida foram maiores na obesidade abdominal de ambos os sexos. Os meninos com níveis séricos insuficientes de α-tocoferol expressaram níveis reduzidos de α-1-glicoproteína ácida (p = 0,03) e apresentaram um maior risco de deficiência de 25-hidroxivitamina D e β-caroteno na adiposidade total e abdominal, enquanto as meninas mostraram maior risco de insuficiência de β-caroteno com a obesidade abdominal (RP 1,33; IC 95% 1,2-1,5). Conclusão: A adiposidade abdominal reflete maior risco de inflamação e causa alterações distintas nas concentrações das vitaminas lipossolúveis, de acordo com o sexo.


Subject(s)
Humans , Female , Child , Adolescent , Vitamins/metabolism , Adiposity/physiology , Inflammation/metabolism , Obesity/metabolism , Reference Values , Vitamin D/analogs & derivatives , Orosomucoid/analysis , Carotenoids/blood , Anthropometry , Nutritional Status , Cross-Sectional Studies , Inflammation/etiology , Inflammation/physiopathology , Obesity/complications , Obesity/physiopathology
SELECTION OF CITATIONS
SEARCH DETAIL