Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 2.049
Filter
1.
Article in English | LILACS, BBO | ID: biblio-1550595

ABSTRACT

ABSTRACT Objective: To assess the impact of Molar Incisor Hypomineralization (MIH) and confounding factors on oral health-related quality of life (OHRQoL) according to the perception of 8 to 10-year-old children and their parents/caregivers. Material and Methods: A cross-sectional study including 403 students aged 8-10 years was carried out, in which OHRQoL was measured using the Child Perceptions Questionnaire administered to both children and parents/caregivers. The diagnosis of MIH was performed according to the previously proposed index. Dental caries experience, malocclusion, and sociodemographic factors were evaluated as confounders. Cluster analysis and Poisson regression with robust variance (p<0.05) were performed. Results: The prevalence of MIH was 13.4%. Parents/caregivers of children with MIH in incisors showed a higher impact prevalence in the emotional well-being domain (PR=1.92; 95%CI=1.16-3.19). Children with hypoplasia had a higher prevalence of negative impact on OHRQoL in the oral symptoms domain (PR=1.51; 95%CI=1.03-2.23). According to the perception of parents/caregivers, dental caries experience had a negative impact on the quality of life of students in the emotional well-being domain (PR=4.19; 95%CI=1.06-16.49) and in the total questionnaire score (PR=3.21; 95%CI=1.06-9.71). Conclusion: According to the perception of parents/caregivers, children with MIH in incisors showed a greater impact on OHRQoL. Additionally, the presence of hypoplasia affected the self-perception of OHRQoL in children, and caries experience influenced the OHRQoL of children, as perceived by parents/caregivers.


Subject(s)
Humans , Male , Female , Child , Quality of Life , Tooth Demineralization , Dental Enamel Hypoplasia , Molar Hypomineralization/epidemiology , Oral Health , Cross-Sectional Studies/methods , Confounding Factors, Epidemiologic , Surveys and Questionnaires , Data Interpretation, Statistical , Dental Caries/epidemiology , Observational Study
2.
Cienc. Salud (St. Domingo) ; 8(1): [9], 2024. tab, graf
Article in Spanish | LILACS | ID: biblio-1551342

ABSTRACT

Objective: To evaluate the clinical response of patients with cystic fibrosis and primary ciliary dyskinesia after endoscopic sinus surgery at the Dr. Robert Reid Cabral Children's Hospital from September 2021 to February 2022. Methods: An ambispective, cross-sectional, observational case series study was conducted, where the study population was made up of patients with cystic fibrosis and primary ciliary dyskinesia at the Dr. Robert Reid Cabral children's hospital during the study period. Inclusion criteria: Patients older than 6 years with a confirmed diagnosis of cystic fibrosis and primary ciliary dyskinesia (Genetic test with 2 homozygous mutations, positives electrolytes in sweat), severe respiratory symptoms of CRS that did not improve with conventional treatment and underwent endoscopic surgery for sinuses. Results: Of a total of 41 patients, only 10 met the inclusion criteria, the most prevalent age range was 14 to 18 years. Both CF and PCD patients decreased the frequency of CRS symptoms. After ENC, there were discrete changes in lung function, and only patients with severe to moderate disease increased % of FEV1. Most of the patients did not require admission after surgery. The most common germ found in nasopharyngeal and sputum cultures in preoperative patients was Pseudomonas aeruginosa in 86%; after ESS there was a significant increase in MRSA colonization in both CF and PCD patients. More than 50% of postoperative patients improved their quality of life, so endoscopic sinus surgery is effective in this population in the treatment of chronic rhinosinusitis.


Objetivo: Evaluar la respuesta clínica de los pacientes con fibrosis quística y discinesia ciliar primaria posterior a la cirugía endoscópica de senos paranasales en el Hospital Infantil Dr. Robert Reid Cabral en el período septiembre 2021 a febrero 2022. Métodos: Se realizó un estudio observacional tipo serie de casos, de corte transversal y ambispectivo, donde la población estudiada estuvo conformada por los pacientes con fibrosis quística y discinesia ciliar primaria del hospital infantil Dr. Robert Reid Cabral en el período de estudio. Criterios de inclusión: Pacientes mayores de 6 años con diagnóstico confirmado de fibrosis quística y discinesia ciliar primaria (Prueba genética con 2 mutaciones homocigotas, electrolitos en sudor positivos), síntomas respiratorios severos de RSC que no mejoraron con tratamiento convencional y sometidos a la cirugía endoscópica de senos paranasales. Resultados: De un total de 41 pacientes, sólo 10 cumplieron con los criterios de inclusión, el rango de edad más prevalente fue de 14 a 18 años. Tanto los pacientes con FQ como los de DCP disminuyeron la frecuencia de los síntomas de RSC. Posterior a la CEN hubo cambios discretos en la función pulmonar, y sólo los pacientes con enfermedad grave a moderada aumentaron el % de FEV1. La mayoría de los pacientes no ameritaron ingresos posterior a la cirugía. El germen más común encontrado en los cultivos nasofaríngeo y esputo en los pacientes preoperatorios fue la Pseudomonas aeruginosa en el 86%, luego de la CEN hubo un aumento significativo de la colonización por MRSA tanto en los pacientes con FQ como en los de DCP. Más del 50% de los pacientes postquirúrgicos mejoraron su calidad de vida, por lo que la cirugía endoscópica de senos paranasales es efectiva en dicha población en el tratamiento de la rinosinusitis crónica.


Subject(s)
Humans , Male , Female , Adolescent , Sinusitis , Ciliary Motility Disorders , Cystic Fibrosis , Paranasal Sinus Diseases , Quality of Life , Observational Study
3.
Article in English | LILACS, BBO | ID: biblio-1529142

ABSTRACT

Abstract Objective: To investigate the usefulness, reliability, quality, and content of Portuguese-language YouTube videos on COVID-19. Material and Methods: Three keywords selected on Google Trends were searched on YouTube, and the 60 first videos listed with each term were analyzed. Two calibrated researchers evaluated the reliability (DISCERN Modified Scale), the quality (Global Quality Score - GQS), and the usefulness of videos for the users (COVID-19 Specific Score - CSS). The number of views, likes, and engagement were also analyzed. The data were evaluated by the Mann-Whitney test and Spearman correlation (α=5%). Results: 59 videos were included. The average scores of quality, reliability, and usefulness were 3.0 (±1.1), 3.2 (± 0.8), and 1.5 (± 0.9), respectively. Two-thirds of the videos (64.4%) had low/moderate quality, and the majority (76.2%) were about signs and symptoms. The numbers of views (p=0.005), likes (p=0.006), and engagement (p=0.014) were significantly higher in moderate/good quality videos. The number of comments (p=0.007), duration of videos (p=0.004), and the DISCERN score (p<0.001) were significantly higher in videos made by health professionals. The general quality of the videos was positively correlated to the CSS scores, number of views, likes, and engagement (p<0.05). Conclusion: Most videos had moderate quality and reliability and low usefulness for the users.


Subject(s)
Health Communication , Data Accuracy , Internet-Based Intervention , COVID-19/prevention & control , Video Recording , Statistics, Nonparametric , Dentists , Social Networking , Observational Study
4.
Rev. Ciênc. Plur ; 9(3): 32620, 26 dez. 2023. tab, ilus, graf
Article in Portuguese | LILACS, BBO | ID: biblio-1524464

ABSTRACT

Introdução:Sabe-se que a busca pela estética é algo cada vez mais crescente. Dentre os procedimentos mais procurados na odontologia estética, destaca-se o clareamento dental de consultório. Diante disso, ainda são poucos os estudos que avaliam os efeitos dos agentes clareadores de diferentes pHs na efetividade clareadora e na sensibilidade dentária.Objetivo:Avaliar a sensibilidade dentária e a eficácia clareadora de géis clareadores à base de peróxido de hidrogênio a 35% com diferentes pHs.Metodologia:Trata-se de um relato de três casos, descritivo e observacional, do tipo boca dividida (split-mouth) para cada estratégia clareadora (gel clareador com pH básico e gel clareador com pH ácido). Foram avaliados três pacientes de25, 26e 27anos de idade.Realizou-se registro de cor por meio da escala VITAClassical e avaliação da sensibilidade dentária pela escala visual analógica. Resultados:Todos os pacientes avaliados apresentaram cor A3 no registro de cor inicial e, após o clareamento dental,atingiram a cor A1. Todos relataram uma maior sensibilidade no hemiarco direito (local onde foi aplicada o gel clareador Whiteness HP que possui pH ácido. Dois pacientes relataram sensibilidade dentária no hemiarco esquerdo em que foi aplicado o gel clareador de pH básico. Conclusões:Observa-se a eficácia clínica dos géis clareadores de consultório à base de peróxido de hidrogênio a 35% na estabilidade de cor após o tratamento clareador, independente do seu pH. Ademais, nota-se que o gel clareador de pH básico promoveu menor sensibilidade pós-operatória (AU).


Introduction:It is known that the search for aesthetics is something increasingly growing. Among the most sought-after procedures in cosmetic dentistry, in-office tooth bleaching stands out. Therefore, there are still few studies that evaluate the effects of bleaching agents ofdifferent pHs on bleaching effectiveness and tooth sensitivity.Objective:To evaluate tooth sensitivity and bleaching efficacy of 35% hydrogen peroxide-based tooth bleaching gels with different pHs.Methodology:This is a report of three cases, descriptive and observational, of the split-mouth type for each bleaching strategy (bleaching gel with basic pH and bleaching gel with acidic pH). Three patients aged 25, 26 and 27 years were evaluated. Color registration was performed using the VITA Classical scale and tooth sensitivity was evaluated using the visual analogue scale.Results:All evaluated patients presented color A3 in the initial color registration and, after tooth bleaching, reached color A1. All reported greater sensitivity in the right hemi-arch (place where the Whiteness HP bleaching gel with an acid pH was applied. Two patients reported tooth sensitivity in the left hemi-arch where the basic pH bleaching gel was applied.Conclusions:The clinical efficacy of in-office tooth bleaching gels based on 35% hydrogen peroxide in terms of color stability after bleaching treatment is observed, regardless of its pH. In addition, it is noted that the basic pH bleaching gel promoted less postoperative sensitivity (AU).


Introducción: Se sabe que la búsqueda de la estética es algo cada vez más creciente. Entre los procedimientos más populares en odontología estética, se destaca el blanqueamiento dental en consultorio. Ante esto, aún existen pocos estudios que evalúen los efectos de agentes blanqueadores de diferentes pHs sobre la efectividad del blanqueamiento y la sensibilidad dental.Objetivo: Evaluar la sensibilidad dental y la eficacia blanqueadora de geles blanqueadores a base de peróxido de hidrógeno al 35 % con diferentes pH. Metodología: Este es un reporte de tres casos, descriptivo y observacional, del tipo boca partida para cada estrategia de blanqueamiento (gel blanqueador con pH básico y gel blanqueador con pH ácido). Se evaluaron tres pacientes de 25, 26 y 27 años. El registro de color se realizó con la escala clásica VITA y la sensibilidad dental se evaluó con la escala analógica visual.Resultados: Todos los pacientes evaluados presentaron color A3 en el registro de color inicial y, después del blanqueamiento dental, alcanzaron el color A1. Todos refirieron mayor sensibilidad en la hemiarcada derecha (lugar donde se aplicó el gel blanqueador de pH ácido Whiteness HP). Dos pacientes refirieron sensibilidad dental en la hemiarcadaizquierda donde se aplicó el gel blanqueador de pH básico.Conclusiones: Se observala eficacia clínica de los geles blanqueadores de consultorio a base de peróxido de hidrógeno al 35% en cuanto a la estabilidad del color tras el tratamiento blanqueador, independientemente de su pH. Además, se observa que el gel blanqueador de pH básico promovió una menor sensibilidad postoperatoria (AU).


Subject(s)
Humans , Adult , Color , Dentin Sensitivity/complications , Tooth Bleaching Agents/adverse effects , Hydrogen Peroxide , Treatment Outcome , Observational Study , Hydrogen-Ion Concentration
5.
Article in Spanish | LILACS, CUMED | ID: biblio-1536339

ABSTRACT

Introducción: El carcinoma basocelular es un tumor de invasión local de crecimiento; se origina en las células epidérmicas de los folículos pilosos o las células basales de la epidermis, cuando se localizan en zona de alto riesgo en la cara tienen un mayor índice de recurrencia tumoral y de invasión a estructuras adyacentes y subyacentes. Objetivo: Evaluar los resultados de la aplicación del HeberFERON en pacientes con carcinoma basocelular en zona de alto riesgo. Métodos: Se realizó un estudio observacional, descriptivo y prospectivo en pacientes con diagnóstico clínico, dermatoscópico e histopatológico de carcinoma basocelular en zona de alto riesgo, tratados con HeberFERON en la consulta del Policlínico Centro de Sancti Spíritus desde el 12 de enero de 2016 hasta el 25 de marzo de 2022. La muestra quedó conformada por 62 pacientes Las principales variables estudiadas fueron la respuesta al tratamiento y los eventos adversos. Resultados: Predominó el sexo masculino, el área urbana, fototipocutáneo III y la edad mayor de 40 años. La localización más frecuente fue la nasal; el subtipo clínico el nódulo ulcerativo; el histológico, el sólido; el tumor primitivo y menor de 2 cm; la respuesta al tratamiento fue completa en la mayoría de los pacientes. Los eventos adversos más comunes fueron dolor y ardor en el sitio de inyección, edema y eritema perilesional, fiebre y cefalea. Conclusiones: La mayoría de los pacientes tratados con HeberFERON tuvieron una respuesta completa, los eventos adversos fueron los descritos en la literatura por el uso de interferones, sin cambio en la actitud farmacológica(AU)


Introduction: Basal cell carcinoma is a growing and locally invasive tumor; it originates in the epidermal cells of hair follicles or the basal cells of the epidermis. When located in a high-risk facial zone, they present a higher rate of tumor recurrence and invasion to adjacent and underlying structures. Objective: To evaluate the results of HeberFERON application in patients with basal cell carcinoma on a high-risk zone. Methods: An observational, descriptive and prospective study was conducted in patients with a clinical, dermatoscopic and histopathological diagnosis of basal cell carcinoma on a high-risk zone, treated with HeberFERON in the consultation of Policlínico Centro of Sancti Spíritus, from January 12, 2016 to March 25, 2022. The sample was made up of 62 patients. The main variables studied were response to treatment and adverse events. Results: There was a predominance of the male sex, the urban area, skin phototype III and age over 40 years. The most frequent localization was nasal; the clinical subtype, ulcerative nodule; the histological subtype, solid. The response to treatment was complete in most patients. The most common adverse events were pain and burning at the injection site, perilesional erythema and edema, fever and headache. Conclusions: Most patients treated with HeberFERON had a complete response; the adverse events were those described in the literature due to the use of interferons, with no change in pharmacological behavior(AU)


Subject(s)
Humans , Male , Female , Skin Neoplasms/epidemiology , Carcinoma, Basal Cell/diagnosis , Carcinoma, Basal Cell/drug therapy , Interferons/therapeutic use , Epidemiology, Descriptive , Prospective Studies , Observational Study
6.
Article in Spanish | LILACS, CUMED | ID: biblio-1536336

ABSTRACT

Introducción: El impacto psicológico de la pandemia en la población varía de acuerdo al tipo de afección, por el significado que implica a la persona y sus características. Objetivos: Determinar el riesgo de depresión, ansiedad, estrés y suicidio en pacientes en aislamiento por contacto de casos sospechosos de COVID-19. Métodos: Estudio observacional transversal en pacientes en aislamiento domiciliario por contacto de casos sospechosos de COVID-19, Policlínico José Martí Pérez del municipio Gibara, de noviembre del 2020 a febrero del 2021. El universo fue 417 pacientes, de ellos 399 fue la muestra mediante un muestreo no probabilístico y cumplieron los criterios de inclusión y exclusión. Se recolectó a través de test que evaluaron las alteraciones psicológicas. La información recogida fue almacenada en una base de datos, y se procesó mediante la utilización del paquete estadístico SPSS 17. Resultados: Predominaron pacientes aislados por contacto directo (194/48,62 por ciento) y en aislamiento por más a 10 días (203/50,89 por ciento). El ser contacto de cualquier tipo de paciente sospechoso de COVID-19 se relacionó con riesgo de depresión (OR: 1,81; IC 95 por ciento: 1,38-2,38), pero no con la ansiedad (OR: 1,05; IC 95 por ciento 0,88-1,25). El estrés no presentó significación estadística (p = 0,341) en relación al tiempo en aislamiento. La ideación suicida estuvo presente en 25 pacientes, relacionándose con el riesgo de sufrirla (OR: 1,39; IC 95 por ciento: 1,03-1,88) en pacientes contactos directos. Conclusiones: Durante el aislamiento, los pacientes presentaron ansiedad como principal alteración psicológica, al estar en contacto con pacientes positivos de COVID-19. Esta situación se relaciona estrechamente con el riesgo de sufrir depresión y presentar idea suicida(AU)


Introduction: The pandemic's psychological impact of the on the population varies depending on the type of condition, according to the meaning that it implies to the person and its characteristics. Objectives: To determine the risk of depression, anxiety, stress and suicide in patients in isolation due to contact with suspected cases of COVID-19. Methods: A cross-sectional and observational study was carried out with patients in home isolation due to contact with suspected cases of COVID-19. The patients belonged to the Policlínico José Martí Pérez, Gibara Municipality, from November 2020 to February 2021. From a study universe of 417 patients, 399 were selected by nonprobabilistic sampling, apart from the fact that they met the inclusion and exclusion criteria. The psychological alterations were evaluated through the application of a test. The collected information was stored in a database and processed using the SPSS 17 statistical package. Results: There was a predominance of patients isolated due to direct contact (194/48, 62 percent) and in isolation for more than 10 days (203/50, 89 percent). Having been in contact with any type of patient suspected of COVID-19 was associated with risk of depression (OR: 1.81; 95 percentI: 1.38-2.38), but not with anxiety (OR: 1.05; 95 percent CI: 0.88-1.25). Stress was not statistically significant (p = 0.341) in relation to the isolation time. Suicidal ideation was present in 25 patients, being related, in patients who were direct contact, to the risk of suffering from the disease (OR: 1.39; 95 percent I: 1.03-1.88). Conclusions: During isolation, patients presented anxiety as the main psychological alteration, since they had been in contact with COVID-19 positive patients. This situation is closely related to the risk of suffering depression and presenting suicidal ideation(AU)


Subject(s)
Humans , Male , Female , Anxiety/psychology , Suicide/psychology , Depression/psychology , COVID-19/epidemiology , Stress, Psychological/psychology , Cross-Sectional Studies , Observational Study
7.
Article in Spanish | LILACS, CUMED | ID: biblio-1536335

ABSTRACT

Introducción: Múltiples investigaciones demuestran el efecto teratogénico de la diabetes mellitus durante el embarazo, considerada causa frecuente de morbilidad fetal. Objetivo: Describir las características del producto de la concepción de mujeres con diabetes pregestacional o gestacional, atendidas en el Hospital Provincial Comandante Ciro Redondo García, de Artemisa. Métodos: Se realizó un estudio observacional, descriptivo, transversal, en la Provincia Artemisa, Cuba, en el período de febrero 2016 a febrero 2018, en 316 mujeres con diabetes mellitus durante su gestación. La información se obtuvo mediante revisión documental y entrevista, conservando los datos en hoja de cálculo Excel. Resultados: El 69,9 por ciento de las pacientes diabéticas estudiadas presentaron morbilidades en su descendencia, entre las que predominaron los defectos congénitos en 139 casos; 34 neonatos macrosómicos; 21 pretérminos; 9 con retardo del crecimiento intrauterino y 5 fallecidos antes del año de vida. La diabetes, tanto pregestacional como gestacional, se relacionó con afecciones en la descendencia; sin embargo, un control preconcepcional adecuado de la enfermedad redujo el riesgo de tener hijos afectados. Los defectos congénitos fueron la alteración más frecuente cuando la madre padecía diabetes pregestacional. Si la diabetes materna era gestacional los hijos presentaron con frecuencia macrosomía y otras anomalías asociadas. Conclusiones: Alrededor de 70 de cada 100 mujeres diabéticas presentan morbilidades en su descendencia. Si la diabetes materna no es controlada antes de la concepción, estas morbilidades en sus hijos son predominantemente defectos congénitos con posible origen disruptivo, mientras que la diabetes gestacional se relaciona más con recién nacidos macrosómicos(AU)


Introduction: Multiple investigations show the teratogenic effect of diabetes mellitus during pregnancy, being considered a frequent cause of fetal morbidity. Objective: To describe the characteristics of the offspring of women with pregestacional or gestational diabetes who received attention at the Hospital Provincial Comandante Ciro Redondo García of Artemisa. Methods: An observational, descriptive, cross-sectional and descriptive study was conducted in Artemisa Province, Cuba, in the period from February 2016 to February 2018, with 316 pregnant women with diabetes mellitus. The information was obtained through documentary review and interview; the data were kept in an Excel spreadsheet. Results: 69.9 percent of the studied diabetic patients presented morbidities in their offspring, among which congenital defects predominated, accounting for 139 cases; 34 were macrosomic neonates; 21 were preterm; 9 presented intrauterine growth retardation; and 5 died within one year of life. Diabetes, both pregestational and gestational, was associated with conditions in the offspring; however, adequate preconception control of the disease reduced the risk for having affected children. Congenital defects were the most frequent alteration when the mother had pregestational diabetes. If maternal diabetes was gestational, the offspring frequently presented macrosomia and other associated anomalies. Conclusions: About 70 out of 100 diabetic women present morbidities in their offspring. If maternal diabetes is not controlled before conception, these morbidities in their offspring are predominantly congenital defects with a possible disruptive origin, while gestational diabetes is more related to macrosomic newborns(AU)


Subject(s)
Humans , Female , Pregnancy , Congenital Abnormalities/etiology , Diabetes, Gestational/epidemiology , Diabetes Mellitus , Epidemiology, Descriptive , Cross-Sectional Studies , Observational Study
8.
Oncología (Guayaquil) ; 33(2): 153-161, 14 de agosto del 2023.
Article in Spanish | LILACS | ID: biblio-1451571

ABSTRACT

Introducción: La biopsia selectiva del ganglio centinela (BSGC) en cáncer de mama es el método estándar para estadificación axilar en pacientes con axila clínicamente negativa. Estudios indican evitar linfadenectomía axilar en pacientes con BSGC negativas incluyendo aquellos que recibieron previamente quimioterapia neoadyuvante (QTN). El objetivo del presente estudio es determinar la eficacia de la BSGC en detectar ganglios centinela posterior QTN en un instituto oncológico de referencia en Ecuador. Materiales y Métodos: Estudio observacional, analítico y retrospectivo, realizado en Hospital SOLCA Guayaquil, durante el período enero 2015 a diciembre 2020. Se evaluaron 81 pacientes con cáncer de mama con axila clínicamente negativa que recibieron QTN previo a cirugía. Las variables son biopsia de ganglio centinela, quimioterapia neoadyuvante, precisión diagnóstica y estadificación axilar. Se consideró el Odds Ratio del 95%, con una P<0.05. Resultados: De 81 pacientes operados, 52 pacientes recibieron BSGC con muestreo detectándose ganglio centinela en 92.3% de los casos. El porcentaje de falsos negativos es 21.7% posterior a QTN. Los 29 pacientes restantes recibieron linfadenectomía axilar. Conclusión: La BSGC es efectiva para detectar el ganglio centinela en pacientes con cáncer de mama y axila clínicamente negativa, incluso después de la quimioterapia neoadyuvante. Sin embargo, existe un riesgo significativo de falsos negativos después de la QTN, lo que puede llevar a la necesidad de realizar una linfadenectomía axilar adicional para una evaluación más precisa de la estadificación axilar.


Introduction: Selective sentinel lymph node biopsy (SLNB) in breast cancer is the standard method for axillary staging in patients with clinically negative axilla. Studies indicate avoiding axillary lymphadenectomy in patients with negative SLNB, including those who previously received neoadjuvant chemotherapy (NQT). This study aims to determine the efficacy of SLNB in detecting sentinel lymph nodes after QTN in a reference cancer institute in Ecuador. Materials and Methods: An observational, analytical, and retrospective study was conducted at Hospital SOLCA Guayaquil from January 2015 to December 2020. Eighty-one clinically negative axillary breast cancer patients who received CTN before surgery were evaluated. The variables are sentinel node biopsy, neoadjuvant chemotherapy, diagnostic accuracy, and axillary staging. An odds ratio of 95% was considered, with P <0.05. Results: Of 81 operated patients, 52 received SLNB, with sampling detecting sentinel nodes in 92.3% of the cases. The percentage of false negatives is 21.7% after QTN. The remaining 29 patients received axillary lymphadenectomy. Conclusion: SLNB effectively detects the sentinel node in patients with clinically negative breast and axillary cancer, even after neoadjuvant chemotherapy. However, there is a significant risk of false negatives after CTN, which may lead to the need to perform additional axillary lymphadenectomy for a more accurate assessment of axillary staging.


Subject(s)
Humans , Adult , Biopsy , Sentinel Lymph Node , Lymph Node Excision , General Surgery , Breast Neoplasms , Neoadjuvant Therapy , Observational Study
9.
Rev. Ciênc. Méd. Biol. (Impr.) ; 22(1): 90-97, jun 22, 2023. fig, tab
Article in Portuguese | LILACS | ID: biblio-1443288

ABSTRACT

Introdução: as parasitoses intestinais são doenças que apresentam um problema de saúde mundial, causando grandes problemas nutricionais, onde sua ocorrência varia de acordo com o clima de cada região e condições socioeconômicas. Regiões que apresentam climas trópicos com umidade, altos índices de chuvas e temperaturas elevadas associadas com a falta de informações sobre as enteroparasitoses merecem atenção. Objetivo: o presente trabalho buscou avaliar os tipos de enteroparasitoses entre os anos de 2018 a 2020 em uma parcela da população de um município da Amazônia Ocidental, mais especificamente, (i) avaliar os tipos de enteroparasitoses que acometem a população entre os períodos de inundação e estiagem; (ii) avaliar a influência das enteroparasitoses em indivíduos de acordo com o gênero e a faixa etária ao longo de três anos. Metodologia: as coletas de dados foram realizadas entre os anos de 2018 a 2020, por meio de análises de planilhas concedidas pelo laboratório de análises clinicas LABSUL. Resultados: foram avaliados 4236 exames de fezes, sendo que apenas 1396 foram positivos para enteroparasitoses. Dos quais a maior parte foi causada por protozoários (58,69%) que acometeram principalmente Mulheres, jovens e crianças nos períodos de inundação. Conclusão: diante disso, os dados demonstraram que as enteroparasitoses acometem com frequência uma parcela da população local. Além de trazer informações que podem reforçar a necessidade da implementação do sistema de saneamento básico, juntamente com campanhas de conscientização populacional a respeito das vias de contaminação e da forma de propagação dessas infecções.


Introduction: intestinal parasites are diseases that present a worldwide health problem, causing major nutritional problems, where their occurrence varies according to the climate of each region and socioeconomic conditions. Regions that have tropical climates with humidity, high levels of rainfall and high temperatures associated with a lack of information on entero-parasitosis deserve attention. Objective: the present work sought to evaluate the types of intestinal parasites between the years 2018 to 2020 in a portion of the population of a municipality in the Western Amazon, more specifically, (i) to evaluate the types of entero-parasitosis that affect the population between periods of flooding and drought; (ii) to evaluate the influence of entero-parasitosis in individuals according to gender and age group over three years. Methodology: data collection was carried out between the years 2018 to 2020, through analysis of spreadsheets provided by the clinical analysis laboratory LABSUL. Results: 4236 stool exams were evaluated, of which only 1396 were positive for entero-parasitosis. Most of which were caused by protozoa (58.69%) that mainly affected women, young people and children during flood periods. Conclusion: in view of this, the data showed that intestinal parasites frequently affect a portion of the local population. In addition to bringing information that can reinforce the need to implement the basic sanitation system, together with population awareness campaigns regarding the routes of contamination and the way in which these infections spread.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Aged , Parasitic Diseases , Parasitology , Helminthiasis , Seasons , Cross-Sectional Studies , Observational Study
10.
Rev. Asoc. Méd. Argent ; 136(2): 4-12, jun. 2023. tab, graf
Article in Spanish | LILACS | ID: biblio-1551237

ABSTRACT

Introducción. El shock séptico es la manifestación más grave de sepsis con tasas de letalidad que pueden llegar hasta el 80%. En los últimos años, ha cobrado relevancia la diferencia arteriovenosa de dióxido de carbono, por su implicación teórica en el metabolismo anaerobio y su significado respecto del normal funcionamiento celular. Por lo antes mencionado, creemos necesario realizar un estudio que nos permita establecer la utilidad de la diferencia arteriovenosa de dióxido de carbono en el paciente con shock séptico de la unidad de cuidados intensivos, como medida indirecta de la perfusión tisular y de la utilización de oxígeno por los tejidos, que nos permita establecer un diagnóstico precoz y el pronóstico de los pacientes críticamente enfermos. Métodos. Estudio observacional, descriptivo y transversal. Muestra de veintiocho pacientes adultos. Resultados. Como se ha registrado en otras series, la mayor parte de los pacientes afectados por shock séptico, en nuestro estudio, fueron hombres mayores de 65 años, con al menos una comorbilidad, siendo el principal sitio de infección el respiratorio (67,9%), asociado a una alta tasa de mortalidad (67%). Conclusiones. Los pacientes con diferencia arteriovenosa de PCO2 mayor a 6 mmHg tienen un riesgo aumentado de muerte de 3,2 veces. (AU)


Introduction. Septic shock is the most serious manifestation of sepsis with mortality rates that can reach up to 80%. In recent years, the arteriovenous carbon dioxide difference has gained relevance, due to its theoretical implication in anaerobic metabolism and its significance with respect to normal cell function. Due to the aforementioned, we believe it is necessary to carry out a study that allows us to establish the usefulness of the arteriovenous carbon dioxide difference in the patient with septic shock in the intensive care unit as an indirect measure of tissue perfusion and utilization. of oxygen through the tissues, which allows us to establish an early diagnosis and prognosis of critically ill patients. Methods. Observational, descriptive and cross-sectional study. Sample of 28 adult patients. Results. As has been reported in other series, most of the patients affected by septic shock in our study were men over 65 years of age, with at least one comorbidity, the main site of infection being respiratory (67.9%), associated with a high mortality rate (67%) Conclusions. Patients with an arteriovenous PCO2 difference greater than 6 mmHg have a 3.2-fold increased risk of death. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Shock, Septic/mortality , Carbon Dioxide/blood , Blood Gas Analysis , Cross-Sectional Studies , Observational Study
11.
J. bras. econ. saúde (Impr.) ; 15(1): 39-51, Abril/2023.
Article in English, Portuguese | LILACS, ECOS | ID: biblio-1437940

ABSTRACT

Objetivo: A depressão resistente ao tratamento (DRT) é uma preocupação primária no Brasil devido à sua natureza onerosa e complexa, enquanto o diagnóstico e o tratamento geralmente são desafiadores. O presente manuscrito apresenta os resultados clínicos de um ano de acompanhamento em pacientes com DRT em tratamento padrão (SOC) no subgrupo brasileiro do estudo de Depressão Resistente ao Tratamento na América Latina (TRAL). Métodos: Essa fase longitudinal do estudo TRAL tinha como meta caracterizar alterações nos resultados clínicos e outras variáveis de interesse (p. ex., qualidade de vida, incapacidade) em um ano de acompanhamento em pacientes com DRT em 10 centros no Brasil. Os pacientes incluídos tinham diagnóstico clínico de DRT com base nos critérios DSM-5 e confirmado por MINI. A Escala de Depressão de Montgomery-Asberg (MADRS) era usada para avaliar a gravidade da doença e os resultados clínicos. Outras escalas de depressão e instrumentos classificados pelo paciente eram usadas para medir resultados correlacionados. Resultados: Cento e cinquenta e oito pacientes com DRT, na maioria mulheres (84,4%) com idade média de 48,55 anos, foram incluídos na análise. Apenas 31,4% dos pacientes apresentaram uma resposta clinicamente significativa, 10,3% tiveram recidiva e 26,7% alcançaram remissão, conforme medido pela MADRS no final do estudo (EOS). Aproximadamente 55% dos pacientes apresentavam depressão grave/moderadamente grave no EOS. Problemas de mobilidade, cuidados pessoais, problemas nas atividades usuais e dor e desconforto foram relatados pela maioria dos pacientes no EOS, assim como comprometimento marcado/extremo das atividades no trabalho/escola e da vida social/das atividades de lazer no EOS. Conclusões: Os resultados clínicos alcançados atualmente ainda são notavelmente insatisfatórios para DRT. Portanto, o envolvimento de todas as partes interessadas é essencial para implementar protocolos de tratamento mais eficazes no Brasil.


Objective: Treatment-resistant depression (TRD) is a primary concern in Brazil due to its burdensome and complex nature, while diagnosis and treatment is often challenging. The current manuscript presents the clinical outcomes in a one-year follow-up of TRD patients under Standard-of-care (SOC) in the Brazilian subset of the Treatment-Resistant Depression in America Latina (TRAL) study. Methods: This longitudinal phase of TRAL aimed to characterize changes in the clinical outcomes and other variables of interest (e.g. quality of life, disability) in a one-year follow-up of TRD patients in 10 centers in Brazil. Included patients were clinically diagnosed with TRD based on DSM-5 criteria and confirmed by MINI. Montgomery-Asberg Depression Rating Scale (MADRS) was used to assess disease severity and clinical outcomes. Other depression scales and patient rated instruments were used to measure correlated outcomes. Results: One hundred fifty-eight TRD patients, mostly female (84.4%), averaging 48.55 years, were included in the analysis. Only 31.4% of the patients showed a clinically significant response, 10.3% had a relapse and 26.7% achieved remission, as measured through MADRS at end-of-study (EOS). Almost 55% of the patients showed moderately severe/severe depression at EOS. Mobility issues, self-care, problems with usual activities and pain and discomfort were reported by the majority of the patients at EOS, as well as marked/extreme disruption of school/work and social life/leisure activities at EOS. Conclusions: Currently achieved clinical outcomes are still remarkably unsatisfactory for TRD. Therefore, the involvement of all relevant stakeholders is essential to implement more effective treatment protocols in Brazil.


Subject(s)
Multicenter Study , Depressive Disorder, Major , Depressive Disorder, Treatment-Resistant , Observational Study
12.
Educ. med. super ; 37(1)mar. 2023. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1440010

ABSTRACT

Introducción: Una vez diagnosticado el primer caso de COVID-19 en Cuba ya existía diseñado un escenario de capacitación para los estudiantes de todas las carreras de las ciencias médicas que en su formación deben interiorizar las responsabilidades que la medicina implica, y que no solo se limita a la adquisición de conocimientos científicos y académicos. Objetivo: Determinar los conocimientos de los estudiantes de las ciencias médicas de Camagüey para realizar la pesquisa activa a la COVID-19. Métodos: Se hizo un estudio observacional, descriptivo, de corte transversal en septiembre de 2021. El universo de estudio fue de 2573 estudiantes, pertenecientes a todas las carreras de ciencias médicas, que se encontraban en el pesquisaje activo a la COVID-19 en el municipio Camagüey. Por muestreo no probabilístico por conveniencia se seleccionó una muestra de 416 estudiantes en ocho áreas de salud de este municipio. Se elaboró y validó una encuesta descriptiva, cualitativa, personal, que contenía preguntas abiertas y cerradas. Resultados: La muestra estuvo representada por el sexo femenino en un 70,7 por ciento y el mayor porcentaje perteneció de la facultad de medicina con el 73 por ciento. El 55 por ciento respondió tener una buena preparación para la realización de la pesquisa activa a la COVID-19 y el 79,8 % reconoció a la televisión como la vía más significativa para la adquisición de los conocimientos. El 93,3 por ciento consideró los métodos clínico y epidemiológico como significativos para desarrollar la actividad. Conclusiones: En la presente investigación predominó el sexo femenino; asimismo, se reconoció a la televisión como la mejor vía para la adquisición de conocimientos y la mayoría de los participantes expresó el valor del método clínico epidemiológico para adquirir conocimientos. Se consideró que se debía dotar a los estudiantes de las herramientas para su autopreparación para explotar aún más el escenario virtual y las plataformas vigentes(AU)


Introduction: When the first case of COVID-19 was diagnosed in Cuba, a training setting had already been designed for students of all the majors in the field of medical sciences who, as part of their training, should internalize the responsibilities that medicine implies, which is not only limited to the acquisition of scientific and academic knowledge. Objective: To determine the medical sciences students from Camagüey's knowledge for performing active COVID-19 screening. Methods: An observational, descriptive and cross-sectional study was carried out in September 2021. The study universe was 2573 students, belonging to all the majors in the field of medical sciences who were involved in active COVID-19 screening within the Camagüey Municipality. A sample of 416 students was selected in eight health areas of this municipality, by using nonprobabilistic convenience sampling. A descriptive, qualitative, individual survey containing open and closed questions was elaborated and validated. Results: The sample was represented by the female sex in a 70.7 percent, while the highest percentage belonged to the medical school (73 percent). 55 percent responded that they had a good training for carrying out active COVID-19 screening and 79.8 percent recognized television as the most significant way for knowledge acquisition. 93.3 percent considered that the clinical and epidemiological methods were significant to develop the activity. Conclusions: In the present research, the female sex predominated. Likewise, television was recognized as the best way for knowledge acquisition and most of the participants expressed the value of the clinical-epidemiological method for acquiring knowledge. It was considered that students should be provided with the tools for self-training to exploit the virtual setting and the active platforms even more(AU)


Subject(s)
Humans , Male , Female , Research/education , Health Knowledge, Attitudes, Practice , COVID-19/prevention & control , Television , Epidemiology, Descriptive , Cross-Sectional Studies , Observational Study
13.
Rev. méd. hered ; 34(1): 20-26, ene. - mar. 2023. tab
Article in Spanish | LILACS, LIPECS | ID: biblio-1442072

ABSTRACT

Objetivos: Identificar los factores asociados a la anemia en niños menores de cinco años de edad del distrito de La Libertad, Huaraz, Ancash. Material y métodos: Estudio de tipo cuantitativo, observacional, serie de casos comparativa, retrospectiva. Cuya población de estudio fueron los niños menores de cinco años de edad del distrito de La Libertad, Huaraz, 2019. El muestreo fue de tipo probabilístico. Se recolectaron datos de la historia clínica en torno a los factores intrínsecos y extrínsecos para anemia. Se realizó un análisis exploratorio para determinar los factores asociados. Se analizó la información en hojas de cálculo del software Microsoft Excel 2013® y en el programa estadístico IBM SPSS Statistics 22. Resultados: Predominó el nivel de anemia moderado con 30%. Tanto el sexo masculino (OR=3,66; IC 95%: 1,65-8,08) y la edad mayor de 1 año (OR=13,99; IC 95%: 3,07-63,77) fueron factores intrínsecos asociados a la mayor frecuencia de anemia (p<0,05). Respecto a los factores extrínsecos, el pertenecer a un caserío diferente a Cajamarquilla (OR=3,63; IC 95%: 1,44-9,16) y el no contar con servicios básicos completos (OR=2,72; IC 95%: 1,24-5,97) se asociaron también a un incrementado número de casos (p<0,05). Conclusiones: Los factores asociados a una mayor frecuencia de casos de anemia fueron el sexo masculino, la edad mayor de 1 año, el pertenecer a un caserío diferente a Cajamarquilla y el no contar con servicios básicos completos.


SUMMARY Objectives: To identify associated factors to anemia in children under five years of age in La Libertad District, Huaraz, Ancash. Methods: It is a quantitative, observational, comparative case series, retrospective study. The population was children under five years of age in La Libertad District, Huaraz, 2019. The sampling was Probabilistic. Medical history data were collected around intrinsic and extrinsic factors for anemia. An exploratory analysis was performed to determine the associated factors. The information was analyzed in Microsoft Excel 2013 software spreadsheets® and in IBM SPSS Statistics 22 program. Results: The level of moderate anemia prevailed with 30%. Both males (OR=3.66; CI 95%: 1.65-8.08) and age older than 1 year (OR=13.99; 95% CI: 3.07-63.77) were intrinsic factors associated with the higher frequency of anemia (p<0.05). Regarding the extrinsic factors, belonging to a hamlet different to Cajamarquilla (OR=3.63; CI 95%: 1.44-9.16) and not having complete basic services (OR=2.72; CI 95%: 1.24-5.97) were also associated with a higher number of cases (p<0.05). Conclusions: The factors associated with a higher frequency of anemia cases were male sex, age over 1 year, belonging to a hamlet different to Cajamarquilla and not having complete basic services.


Subject(s)
Humans , Child, Preschool , Peru , Child , Risk Factors , Anemia , Observational Study
14.
Article in Spanish | LILACS, CUMED | ID: biblio-1508246

ABSTRACT

Introducción: En la historia de la humanidad nunca antes una pandemia había causado tanta desolación y tristeza ni destruido a tantas familias con un impacto psicosocial tan alarmante. Objetivo: Determinar el impacto psicosocial del diagnóstico del VIH/sida en las familias de pacientes con ese diagnóstico. Métodos: Se realizó un estudio observacional, descriptivo transversal en las familias de pacientes con el diagnóstico del VIH/sida en el policlínico Armando García Aspurú, de Santiago de Cuba, desde enero del 2018 a enero del 2019. El universo estuvo constituido por las 26 familias que tuvieran al menos un miembro enfermo. Resultados: Las vías más frecuentes de información por las que la familia se enteró fueron por el mismo paciente, seguido de la información por los servicios de salud. La reacción de la familia ante la noticia fue la esperanza de que no fuera cierto, seguido por la depresión y la angustia. En las creencias que manifiesta la familia sobre el VIH prevalecieron las opiniones de que la enfermedad la adquieren personas de vida desorganizada. Sobre las pérdidas laborales, académicas y/o sociales sufridas por la aparición del VIH, 84,6 por ciento refirió rechazo a nivel de la pareja. Ante la estigmatización, la familia determina no hablar de la enfermedad por miedo al rechazo y sensación de vergüenza. Conclusiones: La infección por VIH/sida trasciende con multiplicidad de consecuencias en variados niveles. Los grandes impactos se relacionan con la familia, donde la estigmatización juega un papel fundamental como intensificador de la conducta familiar y social(AU)


Introduction: Never before in the history of humankind had a pandemic caused so much desolation and sadness or destroyed so many families with such an alarming psychosocial impact. Objective: To determine the psychosocial impact of the HIV/AIDS diagnosis on the families of patients with this diagnosis. Methods: An observational, descriptive and cross-sectional study was carried out in the families of patients with the HIV/AIDS diagnosis in the Armando García Aspurú polyclinic, of Santiago de Cuba, from January 2018 to January 2019. The study universe was made up of the 26 families with at least one sick member. Results: The most frequent ways of information by which the family found out were from the patient herself/himself, followed by information from the health services. The family's reaction to the news was hope that it was not true, followed by depression and anguish. In the beliefs expressed by the family about HIV, there was a prevalence of opinions related to the idea that the disease is acquired by people with a disorganized life. Regarding occupational, academic or social losses suffered due to the appearance of HIV, 84.6 percent reported rejection from her/his couple. Before stigmatization, the family determines not to talk about the disease, due to fear of rejection and the feeling of shame. Conclusions: HIV/AIDS infection transcends with a multiplicity of consequences at various levels. The major impacts are related to the family, where stigmatization plays a fundamental role as an intensifier of family and social behavior(AU)


Subject(s)
Humans , Rejection, Psychology , Stereotyping , Family/psychology , Acquired Immunodeficiency Syndrome/diagnosis , Psychosocial Impact , Epidemiology, Descriptive , Cross-Sectional Studies , Observational Study
15.
Acta neurol. colomb ; 39(1): 20-27, ene.-mar. 2023. tab, graf
Article in Spanish | LILACS | ID: biblio-1429570

ABSTRACT

RESUMEN INTRODUCCIÓN. El ACV menor hace referencia a un evento isquémico que cursa con síntomas leves. Se ha señalado que estos pacientes pueden presentar un desenlace clínico desfavorable. OBJETIVO: Evaluar el desenlace funcional a 90 días de pacientes con ACV isquémico menor, atendidos en dos hospitales de Bucaramanga, Colombia, entre los años 2015 y 2017. MÉTODOS. Estudio de cohorte en pacientes con ACV isquémico agudo y un puntaje NIHSS ≤ 5 puntos. Un desenlace clínico desfavorable a 90 días de seguimiento fue medido como un puntaje Rankin-m ≥ 3 puntos. Se realizó un análisis bivariado a través de modelos de regresión binomial simple y ajustado por edad y sexo. Un valor p <0,05 fue considerado estadísticamente significativo. RESULTADOS. Se incluyeron 90 pacientes (edad de 66,6± 13,5 años, 54,4% (n=49) de sexo masculino). El 36,5% (n=23) de los pacientes presentó un puntaje Rankin-m de 3 a 6 puntos. El antecedente de diabetes mellitus (RR: 2,50 IC 95%:1,33-4,70) y un Rankin-m previo de 2 (RR 2,12 IC 95%:1,39-3,24) fueron variables independientemente asociadas a discapacidad significativa. CONCLUSIÓN. Un estado funcional previamente comprometido, sumado a la disfunción endotelial que genera la diabetes mellitus, contribuye a un desenlace desfavorable en los pacientes con ACV menor.


ABSTRACT INTRODUCTION. Minor stroke refers to an ischemic vascular event that start with discrete symptoms. It has been suggested that these patients may have an unfavorable clinical outcome. AIM. To evaluate the functional outcome at 90 days in patients with minor ischemic stroke in two hospitals in Bucaramanga, between 2015 and 2017. METHODS. Cohort study in patients with acute ischemic stroke and NIHSS ≤ 5 points. An unfavorable clinical outcome was measured according to the modified Rankin Scale as ≥ 3 points. A bivariate analysis was performed through simple binomial regression models adjusted for age and sex. A p-value <0.05 was considered statistically significant. RESULTS. 90 patients were included (Aged 66.6 ± 13.5 years, 49 males (54%); 23 (36,5%) presented a modified Rankin score of 3-6 points. A history of diabetes (RR: 2.50 CI 95%: 1.33-4.70) and a modified Rankin score of 2 points prior to the event (RR 2.12 CI 95%: 1.39-3.24) were independently associated with significant disability CONCLUSION. A previously compromised functional state, added to the endothelial dysfunction generated by diabetes mellitus, contribute significantly to an unfavorable outcome in patients with minor stroke.


Subject(s)
Thrombolytic Therapy , Stroke , Disabled Persons , Observational Study
16.
Natal; s.n; 17 mar. 2023. 126 p. ilus.
Thesis in Portuguese | LILACS, BBO | ID: biblio-1532217

ABSTRACT

Introdução: Os cistos e tumores odontogênicos são lesões que apresentam comportamento biológico heterogêneo e patogênese ainda não totalmente esclarecida. A Yes-associated protein (YAP) atua como um regulador transcricional de genes envolvidos na proliferação celular e na apoptose, participando da ativação de vias associadas ao crescimento cístico e à progressão neoplásica. Objetivo: Analisar a expressão imuno-histoquímica da proteína YAP e correlacioná-la com marcadores envolvidos na proliferação celular e na apoptose em lesões odontogênicas epiteliais benignas. Metodologia: A amostra consistiu de 95 casos de lesões odontogênicas - 25 cistos dentígeros (CDs), 30 CO não sindrômicos (COs), 30 AMB convencionais (AMB-Cs) e 10 AMB unicísticos (AMB-Us) -, além de 10 espécimes de folículo dentários (FD). Foi realizada coleta dos dados clinico-demográficos dos casos, bem como análise morfológica para melhor caracterização da amostra. Os cortes histológicos foram submetidos à técnica imuno-histoquímica através da utilização dos anticorpos YAP, ciclina D1, Ki-67 e Bcl-2, e a análise da expressão destes foi realizada quali-quantitativamente, mediante metodologia adaptada. Os dados coletados seguiram para análise descritiva e estatística (p ≤ 0,05). Resultados: Houve discreta predileção por mulheres (n = 55; 57,6%) e por indivíduos na faixa etária dos 21 aos 40 anos (n = 50; 47,6%), sendo a região posterior de mandíbula mais afetada (64%). A análise da imunoexpressão de YAP revelou maiores níveis de expressão em COs, especialmente nas camadas basal e parabasal, seguido dos AMB-Us e AMB-Cs, que demonstraram moderada imunorreatividade, predominantemente nas células periféricas. Além disso, houve diferenças significativas quanto à imunoexpressão de YAP entre os grupos analisados, com existência de correlações positivas e estatisticamente significativas entre YAP e ciclina D1 em CDs e AMB-Us, e entre YAP e Ki-67 em AMB-Us (p < 0,05). Todavia, entre a imunoexpressão YAP e Bcl-2, foi verificada ausência de correlação estatisticamente significativa. Conclusões: A YAP pode exercer influência sobre a proliferação celular do epitélio de cistos e tumores odontogênicos, auxiliando, assim, na progressão das diferentes lesões odontogênicas (AU).


Background: Odontogenic cysts and tumors present heterogeneous biological behavior, and their etiopathogenesis is not fully understood yet. Yes-associated protein (YAP) acts as a transcriptional regulator of genes involved in cell proliferation and apoptosis, activating pathways associated with cystic growth and neoplastic progression. Objective: To analyze the immunohistochemical expression of YAP protein and correlate it with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions. Methods: The sample consisted of 95 cases of odontogenic lesions - 25 dentigerous cysts (DCs), 30 non-syndromic odontogenic keratocyst (OKCs), 30 conventional AMB (C-AMBs), and 10 unicystic AMB (UAMBs) -, in addition to 10 specimens of dental follicles (DF). Clinicodemographic data collection was carried out, as well as morphological analysis for better characterization of the sample. The histological sections were submitted to the immunohistochemical technique using YAP, cyclin D1, Ki-67, and Bcl-2 antibodies, and their immunoexpression analysis was performed qualitatively and quantitatively, through an adapted methodology. The collected data were submitted for descriptive and statistical analysis (p ≤ 0.05). Results: There was a slight predilection for women (n = 55; 57.6%) and individuals aged between 21 and 40 years (n = 50; 47.6%), with the posterior region of the mandible as the most affected site (64%). Analysis of YAP immunoexpression revealed higher expression levels in OKCs, especially in the basal and parabasal layers, followed by U-AMBs and C-AMBs, which showed moderate immunoreactivity, predominantly in peripheral cells. In addition, there were significant differences in YAP immunoexpression between the analyzed groups, with positive and statistically significant correlations between YAP and cyclin D1 in DCs and U-AMBs, and between YAP and Ki-67 in U-AMBs (p < 0.05). However, between YAP and Bcl-2 immunoexpression, there was no statistically significant correlation. Conclusions: YAP may influence on the cell proliferation of odontogenic cysts and tumors epithelium, thus helping with the progression of the different odontogenic lesions (AU) .


Subject(s)
Cell Proliferation , YAP-Signaling Proteins/metabolism , Transcriptional Coactivator with PDZ-Binding Motif Proteins/metabolism , Dentigerous Cyst/pathology , Biomarkers, Tumor , Medical Records , Retrospective Studies , Data Interpretation, Statistical , Apoptosis , Odontogenic Cyst, Calcifying/pathology , Statistics, Nonparametric , Inhibitor of Differentiation Proteins , Observational Study , Morphological and Microscopic Findings
17.
Educ. med. super ; 37(1)mar. 2023. ilus, tab
Article in Spanish | LILACS, CUMED | ID: biblio-1514075

ABSTRACT

Introducción: La superación en enfermería debe estar dirigida hacia los problemas profesionales, lo cual le permite elevar la calidad de su desempeño pedagógico y asistencial. Objetivo: Caracterizar el proceso de superación profesional del personal de enfermería del Hospital Pediátrico Docente Provincial Dr. Eduardo Agramonte Piña de Camagüey. Métodos: Se realizó un estudio observacional descriptivo y transversal en el Hospital Pediátrico Docente Provincial Dr. Eduardo Agramonte Piña entre enero y junio de 2022. La muestra quedó conformada por 272 enfermeros que cumplieron con los criterios de inclusión. Las variables estudiadas fueron: sexo y grupo etario, años de experiencia laboral, categorías de pregrado hasta la licenciatura, actividades de superación de posgrado, profesionales vinculados a la docencia y participación en actividades científicas a los distintos niveles. Los datos se obtuvieron mediante la aplicación de una encuesta y la revisión del registro del personal de la institución, y se procesaron mediante el programa SPSS versión 26.0 en computadora Pentium V. Resultados: Predominaron los profesionales entre 20 y 29 años (29,0 por ciento), del sexo femenino (92,7 por ciento), con menos de 5 años de experiencia profesional (25 por ciento), en su mayoría licenciados (62,1 por ciento), que no contaban con actividades de superación de posgrado (64,3 por cierto). Solo el 3,3 por ciento tenía categoría docente y participación en eventos científicos a nivel de base (9,9 por ciento). Conclusiones: La superación profesional del personal de enfermería analizado es insuficiente, por lo que se deben diseñar e implementar estrategias de capacitación que den respuesta a esta problemática(AU)


Introduction: Professional improvement in nursing should be directed towards professional problems, which allows to raise the quality of its pedagogical and care performance. Objective: To characterize the professional development process of the nursing staff at Hospital Pediátrico Docente Provincial Dr. Eduardo Agramonte Piña, in Camagüey. Methods: A descriptive, cross-sectional and observational study was carried out at Hospital Pediátrico Docente Provincial Dr. Eduardo Agramonte Piña during January and June 2022. The sample consisted of 272 nurses who met the inclusion criteria. The variables studied were sex and age group, years of work experience, categories from undergraduate to bachelor's degree, postgraduate training activities, professionals linked to teaching, and participation in scientific activities at different levels. The data were obtained by applying a survey and reviewing the institution's personnel registry, as well as processed using the SPSS program (version 26.0) on a Pentium V computer. Results: There was a predominance of professionals between 20 and 29 years of age (29.0 percent), of the female sex (92.7 percent), with less than 5 years of professional experience (25 percent), mostly bachelor's graduates (62.1 percent), and with no postgraduate training activities (64.3 percent). Only 3.3 percent had a teaching rank and participated in scientific events at the institutional level (9.9 percent). Conclusions: Professional improvement of the analyzed nursing staff is insufficient; therefore, training strategies should be designed and implemented to respond to this problem (AU)


Subject(s)
Humans , Professional Training , Nursing Staff/education , Epidemiology, Descriptive , Cross-Sectional Studies , Observational Study
18.
Article in Spanish | LILACS, CUMED | ID: biblio-1508253

ABSTRACT

Introducción: En el curso del envejecimiento es conocida la existencia de un patrón complejo de cambios estructurales cerebrales, conductuales y cognitivos, en ocasiones relacionados con enfermedades neurológicas y psiquiátricas. Objetivo: Determinar la posible relación de causalidad de la atrofia cerebral en la aparición del deterioro cognitivo en el curso del envejecimiento normal. Métodos: Se desarrolló un estudio retrospectivo, transversal, descriptivo y observacional. El universo estuvo conformado por el total de los pacientes de ambos sexos con edades comprendidas entre 35-74 años de edad, con indicaciones previas de tomografía computarizada de cráneo y cuyos resultados fueron informados con signos de atrofia cerebral, cuya cifra ascendió a 733. Resultados: El grupo de edad que predomino fue el de 45-54 años (35,3 por ciento), así como las pacientes del sexo femenino (66,3 por ciento). El 27,7 por ciento tenía como nivel de escolaridad el técnico medio superior y 36,2 por ciento fueron pacientes amas de casa. El 99,7 por ciento fueron diestros. Un total de 368 voluntarios presentaron deterioro cognitivo y 365 sujetos no evidenciaron declive en las funciones exploradas. Las funciones de atención y cálculo y retención verbal a corto plazo fueron las que se vieron más afectadas, seguidas de orientación espacial y memoria verbal de fijación. Conclusiones: No se logró establecer una relación de causalidad significativa entre el diagnóstico radiológico de atrofia cerebral y la presencia de deterioro cognitivo(AU)


Introduction: In the course of aging, the existence of a complex pattern of behavioral, cognitive and cerebral structural changes is known, sometimes related to neurological and psychiatric diseases. Objective: To determine the possible causal relationship of cerebral atrophy with the onset of cognitive impairment in the course of normal aging. Methods: A retrospective, cross-sectional, descriptive and observational study was carried out. The study universe consisted of all patients of both sexes aged 35-74 years, with previous indications for cranial computed tomography and whose results were reported with signs of cerebral atrophy, which numbered 733. Results: The predominant age group was 45-54 years old (35.3percent), as well as female patients (66.3percent). The educational level of 27.7percent of the patients was technical high school and 36.2percent were housewife patients. A total of 99.7percent were right-handed. A total of 368 volunteers showed cognitive impairment and 365 subjects showed no decline in the tested functions. The functions of attention and calculation, as well as short-term verbal retention, were the most affected, followed by spatial orientation and speech retention memory. Conclusions: No significant causal relationship was established between the radiological diagnosis of cerebral atrophy and the presence of cognitive impairment(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aging , Tomography, Emission-Computed/methods , Pick Disease of the Brain/diagnostic imaging , Cognitive Dysfunction/epidemiology , Epidemiology, Descriptive , Cross-Sectional Studies , Retrospective Studies , Observational Study
19.
Article in Spanish | LILACS, CUMED | ID: biblio-1508252

ABSTRACT

Introducción: El residente de Medicina General Integral, una vez graduado, ejecutará investigaciones en correspondencia con las necesidades actuales del Sistema Nacional de Salud y a partir de los problemas de salud predominantes en su comunidad. Objetivo: Describir las principales dificultades en los proyectos de investigación de los residentes de la Especialidad de Medicina General Integral. Métodos: Se realizó un estudio observacional descriptivo transversal en la Facultad de Ciencias Médicas de Sagua la Grande en el período 2020-2021. La población objeto de análisis quedó constituida por un total de 69 proyectos de investigación provenientes de 5 policlínicos docentes de 3 municipios del territorio (Corralillo, Quemado de Güines y Sagua la Grande). Se revisó el proyecto de investigación, se confeccionó un modelo para la recogida de datos extraídos de los mismos y se elaboró una base de datos para su almacenamiento. Resultados: Las principales dificultades estuvieron dadas en no sustentar adecuadamente la investigación, en la redacción del problema científico, específicamente la relación entre el problema y el tipo de investigación, la conceptualización y/o operacionalización de las variables, la selección y elaboración de los métodos, técnicas e instrumentos para la recogida de la información y la acotación de la bibliografía por normas de Vancouver. Conclusiones: Resulta de vital importancia que los residentes de esta especialidad desarrollen habilidades investigativas desde el primer año de formación, lo que contribuirá a un mejor desempeño profesional a partir de la aplicación del método científico en la solución de los problemas de salud que se presenten en su quehacer diario(AU)


Introduction: The family medicine resident, once graduated, will do research in correspondence with the current needs of the national health system and considering the predominant health problems in her/his community. Objective: To describe the main difficulties in the research projects of residents in the General Comprehensive Medicine specialty. Methods: A cross-sectional, descriptive and observational study was carried out in the medical school of Sagua la Grande Municipality, in the period 2020-2021. The population under analysis consisted of a total of 69 research projects from five teaching polyclinics in three municipalities of the territory (Corralillo, Quemado de Güines and Sagua la Grande). Each research project was reviewed, a model was prepared for collecting the data extracted from them, and a database was elaborated for their storage. Results: The main difficulties were not supporting the research adequately, as well as in writing the scientific problem, specifically the relation between the problem and the type of research; also, the conceptualization or operationalization of variables, the selection and elaboration of methods, the techniques and instruments for the collection of information, and the bibliographical adjustment by the Vancouver norms. Conclusions: It is of vital importance that residents of this specialty develop research skills from the first year of training, which will contribute to better professional performance from the application of the scientific method in the solution of health problems that appear in their daily work(AU)


Subject(s)
Humans , Male , Female , Research Design/standards , General Practice , Epidemiology, Descriptive , Cross-Sectional Studies , Observational Study
20.
Rev. cuba. cir ; 62(1)mar. 2023.
Article in Spanish | LILACS, CUMED | ID: biblio-1515255

ABSTRACT

Introducción: La infección de herida quirúrgica causa altas tasas de morbilidad y repercute sobre los índices de mortalidad. Constituye la primera infección intrahospitalaria entre pacientes quirúrgicos del total de infecciones nosocomiales y la primera entre los pacientes quirúrgicos. Existen factores de riesgo como la clasificación ASA, la diabetes mellitus, la hipertensión arterial y los días de estancia hospitalaria, los cuales influyen en su desarrollo. Objetivo: Determinar la prevalencia de infecciones de sitio quirúrgico por cirugías realizadas en el Hospital Dr. Carlos Canseco de Tampico, ciudad del estado mexicano de Tamaulipas. Métodos: Diseño observacional, analítico, transversal y retrospectivo de 54 pacientes con diagnóstico de infección de sitio quirúrgico. Las variables de estudio se clasificaron como dependientes (género, edad, lugar de origen, días de estancia hospitalaria, peso, índice de masa corporal) e independientes (diagnóstico, procedimiento quirúrgico realizado y clasificación ASA otorgada). Resultados: La población de 40 a 50 años fue la más afectada, con mayor predominancia sobre el género femenino. La Clasificación ASA II y III presentaron mayor prevalencia de infección de sitio quirúrgico, sobre todo en cirugías electivas (28 por ciento). Mientras mayor fue la estancia hospitalaria, mayor fue la probabilidad de desarrollar infección de sitio quirúrgico. Conclusiones: La prevalencia de infección en el sitio quirúrgico en pacientes operados por los distintos servicios quirúrgicos no es similar a la reportada por otros autores. La Clasificación ASA II y III presentaron infección del sitio quirúrgico con más frecuencia, mientras que la comorbilidad más llamativa de este estudio fue el índice de masa corporal como factor de riesgo que no debe pasar desapercibido(AU)


Introduction: Surgical wound infection causes high morbidity rates and impacts mortality rates. It is the first in-hospital infection among surgical patients of all nosocomial infections and the first among surgical patients. There are risk factors that influence its development, such as the ASA classification, diabetes mellitus, arterial hypertension and days of hospital stay. Objective: To determine the prevalence of surgical site infections from surgeries performed at Hospital Dr. Carlos Canseco, of Tampico, a city in the Mexican state of Tamaulipas. Methods: An observational, analytical, cross-sectional and retrospective study was carried out with 54 patients with a diagnosis of surgical site infection. The study variables were classified as dependent variables (gender, age, place of origin, days of hospital stay, weight and body mass index) and independent variables (diagnosis, surgical procedure performed, and given ASA classification). Results: The population aged 40 to 50 years was the most affected, with a greater predominance of the female gender. ASA classification II and III had a higher prevalence of surgical site infection, above all in elective surgeries (28 %). The longer the hospital stay, the higher the probability of developing surgical site infection. Conclusions: The prevalence of surgical site infection in patients operated on by the different surgical services is not similar to that reported by other authors. ASA Classification II and III presented surgical site infection more frequently, while the most remarkable comorbidity in this study was body mass index as a risk factor that should not go unnoticed(AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Surgical Wound Infection/epidemiology , Cross-Sectional Studies , Observational Study
SELECTION OF CITATIONS
SEARCH DETAIL