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1.
Int. j. odontostomatol. (Print) ; 13(4): 433-436, dic. 2019. graf
Article in English | LILACS | ID: biblio-1056480

ABSTRACT

ABSTRACT: Periapical cyst originates from an inflammatory reaction in the body that occurs due to a long-term endodontic aggression. It is more prevalent in caucasian male, during the third decade of life, in the anterior portion of the maxilla. They are commonly radiographic findings, due to their asymptomatic aspect. This study reports a Periapical Cyst in the portion corresponding to teeth 21, 22 and 23, which was treated by enucleation of the cyst, apicoectomy and retrograde root filling with Mineral trioxide aggregate (M.T.A) of teeth 21 and 22, filling of the cyst cavity with xenogeneic bone graft GenOx and a collagen membrane Gen-Derm. Observations after three months show good and rapid bone regeneration, periodontal and periapical health of the teeth involved.


RESUMEN: El quiste periapical se origina de una reacción inflamatoria que ocurre debido a una agresión endodóntica a largo plazo. Es más frecuente en el varón caucásico, durante la tercera década de la vida, en la porción anterior del maxilar. Son comúnmente hallazgos radiográficos, debido a su aspecto asintomático. En este estudio informamos acerca de un quiste periapical, en la porción correspondiente a los dientes 21, 22 y 23, que se trató mediante enucleación, apicectomía y relleno de raíz retrógrada con agregado de trióxido mineral (MTA) de los dientes 21 y 22, relleno de la cavidad del quiste con injerto óseo xenogénico Gen-Ox y una membrana de colágeno GenDerm. Las observaciones después de tres meses mostraron una buena y rápida regeneración ósea, con conservación de la salud periodontal y periapical de los dientes involucrados.


Subject(s)
Humans , Male , Middle Aged , Mandibular Diseases/pathology , Mandibular Diseases/diagnostic imaging , Maxillary Diseases/pathology , Maxillary Diseases/diagnostic imaging , Odontogenic Cysts/pathology , Odontogenic Cysts/diagnostic imaging , Bone Transplantation/methods , Radicular Cyst/diagnostic imaging , Bone Substitutes/therapeutic use , Oral Surgical Procedures
2.
Autops. Case Rep ; 9(2): e2018073, Abr.-Jun. 2019. ilus
Article in English | LILACS | ID: biblio-999529

ABSTRACT

A mandibular buccal bifurcation cyst is an inflammatory cyst that usually occurs on the buccal aspect of the permanent mandibular first molar of children. This lesion is diagnosed by an association of radiographic, clinical, and histological features. We report a bilateral case of mandibular buccal bifurcation cyst and discuss the main findings of this entity. A 7-year-old girl presented pain and delayed dental eruption in the posterior mandibular region. A cone beam computed tomography was performed and revealed hypodense lesions involving the crown and root of the mandibular first molars, with expansion of the buccal cortical and lingual tilting of the molar roots. A biopsy was carried out, and the common features of an inflammatory odontogenic cyst were histologically observed. The final diagnosis was bilateral mandibular buccal bifurcation cyst. Clinicians need to be aware of this diagnostic possibility in cases of mandibular cysts in children­especially when bilateral­to perform the correct treatment, which should not involve the extraction of the affected tooth.


Subject(s)
Humans , Female , Child , Mandibular Diseases/pathology , Odontogenic Cysts/diagnostic imaging , Jaw Cysts , Odontogenic Cysts/pathology
3.
Braz. oral res. (Online) ; 31: e34, 2017. tab, graf
Article in English | LILACS | ID: biblio-839511

ABSTRACT

Abstract The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in keratocystic odontogenic tumors associated with Gorlin syndrome (SKOTs) and non-syndromic keratocystic odontogenic tumors (NSKOTs), and to establish correlations with the angiogenic index. Seventeen primary NSKOTs, seven recurrent NSKOTs, and 17 SKOTs were selected for the study. The percentage of immunopositive cells for GLUT-1 and GLUT-3 in the epithelial component of the tumors was assessed. The angiogenic index was determined by microvessel count. The results were analyzed statistically using the nonparametric Kruskal-Wallis test and Spearman’s correlation test. High epithelial immunoexpression of GLUT-1 was observed in most tumors (p = 0.360). There was a higher frequency of negative cases for GLUT-3 in all groups. The few GLUT-3-positive tumors exhibited low expression of this protein in epithelial cells. No significant difference in the angiogenic index was observed between groups (p = 0.778). GLUT-1 expression did not correlate significantly with the angiogenic index (p > 0.05). The results suggest that the more aggressive biological behavior of SKOTs when compared to NSKOTs may not be related to GLUT-1 or GLUT-3 expression. GLUT-1 may play an important role in glucose uptake by epithelial cells of KOTs and this process is unlikely related to the angiogenic index. GLUT-1 could be a potential target for future development of therapeutic strategies for KOTs.


Subject(s)
Humans , Basal Cell Nevus Syndrome/pathology , Glucose Transporter Type 1/analysis , Glucose Transporter Type 3/analysis , Neovascularization, Pathologic/pathology , Odontogenic Cysts/pathology , Odontogenic Tumors/pathology , Basal Cell Nevus Syndrome/metabolism , Epithelial Cells/pathology , Immunohistochemistry , Odontogenic Cysts/chemistry , Odontogenic Tumors/chemistry , Paraffin Embedding , Reference Values , Statistics, Nonparametric
4.
An. bras. dermatol ; 91(4): 541-543, July-Aug. 2016. graf
Article in English | LILACS | ID: lil-792451

ABSTRACT

Abstract: The Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is an uncommon disorder caused by a mutation in Patched, tumor suppressor gene. It is mainly characterized by numerous early onset basal cell carcinomas, odontogenic cysts of jaw and skeletal abnormalities. Due to the wide clinical spectrum, treatment and management of its modalities are not standardized and should be individualized and monitored by a multidisciplinary team. We report a typical case in a 30-year-old man with multiple basal cell carcinomas, keratotic pits of palmar creases and bifid ribs, with a history of several corrective surgeries for keratocystic odontogenic tumors, among other lesions characteristic of the syndrome.


Subject(s)
Humans , Male , Adult , Skin Neoplasms/pathology , Basal Cell Nevus Syndrome/pathology , Scoliosis/pathology , Scoliosis/diagnostic imaging , Radiography, Panoramic , Odontogenic Cysts/pathology , Odontogenic Cysts/diagnostic imaging , Hypertelorism/pathology
5.
Rev. ADM ; 73(1): 23-27, ene.-feb.2016. ilus
Article in Spanish | LILACS | ID: lil-781838

ABSTRACT

El quiste odontogénico ortoqueratinizado es un quiste de desarrollo poco común de los maxilares. Descrito en 1956 por Philipsen como una variante del queratoquiste odontogénico (tumor odontogénico queratinizante) y posteriormente identifi cado como una entidad totalmente aparte por Wrigth, sigue siendo hoy en día una lesión en controversia. En este trabajo se reporta el caso de un paciente masculino de 15 años de edad que acude al Servicio de Cirugía Maxilofacial del Hospital Regional®Lic. Adolfo López Mateos¼, ISSSTE, el cual es diagnosticado como un quiste odontogénico ortoqueratinizado. Tener una adecuada ruta clínica para el diagnóstico clínico, complementado por imagen, y sobre todo contar con el resultado de la biopsia incisional son pasos fundamentales para poder diagnosticar y no sobretratar padecimientos que, con procedimientos menos invasivos y agresivos, tienen mejor pronóstico...


Subject(s)
Humans , Male , Adolescent , Odontogenic Cysts/classification , Odontogenic Cysts/diagnosis , Odontogenic Cysts/pathology , Biopsy/methods , Dental Service, Hospital , Histological Techniques , Mexico , Oral Surgical Procedures/methods , Odontogenic Cysts , Radiography, Panoramic
6.
Rev. bras. cir. plást ; 30(4): 649-653, sep.-dec. 2015. ilus
Article in English, Portuguese | LILACS | ID: biblio-1418

ABSTRACT

Introdução: A síndrome de Gorlin ou síndrome do nevo carcinoma basocelular é uma doença multissistêmica infrequente, com um potencial de desenvolvimento de anormalidades de amplo espectro, como também de desenvolvimento de outras neoplasias. A mesma é autossômica dominante, com alta penetrância e grande variabilidade de expressão, manifesta-se em todos os grupos étnicos, sendo mais prevalente em caucasianos, e com relação entre os sexos de 1:1. Objetivo: Discorrer sobre esta afecção pouco comentada em nosso meio e que pode estar sendo subdiagnosticada e subtratada tanto pelo cirurgião plástico como pelos demais profissionais supostamente envolvidos. Método: Realizada revisão da literatura selecionando artigos sobre síndrome de Gorlin, no banco de dados da Medline/Pubmed de 2009-2013, e descrição da casuística do serviço do Hospital das Clínicas de Ribeirão Preto - USP. Conclusão: A síndrome de Gorlin é uma síndrome multissistêmica, com um amplo espectro de manifestações e grande potencial de mutilação relacionada principalmente ao tratamento de suas três principais alterações/ características. O cirurgião plástico desempenha papel importante na sua detecção e pode colaborar no tratamento abrangente com seguimento adequado aos seus portadores.


Introduction: Gorlin syndrome or nevoid basal cell carcinoma syndrome is a rare multisystemic disease with a potential to cause a broad spectrum of abnormalities and other cancers. It is an autosomal dominant disease with a high penetrance and large variability of expression, manifesting in all ethnic groups but more prevalent in Caucasians, and presenting at a sex ratio of 1:1. Objective: The aim of this study was to discuss Gorlin syndrome, which is little commented on in the literature , and is possibly being underdiagnosed and undertreated by plastic surgeons and other professionals. Method: A literature review was done by selecting articles about Gorlin syndrome from the Medline/PubMed database from 2009 to 2013, and a case-by-case description from the records of the


Subject(s)
Humans , Male , Female , Adult , History, 21st Century , Surgery, Plastic , Review Literature as Topic , Basal Cell Nevus Syndrome , Odontogenic Cysts , Odontogenic Tumors , Basal Cell Nevus Syndrome/surgery , Basal Cell Nevus Syndrome/pathology , Odontogenic Cysts/surgery , Odontogenic Cysts/pathology , Odontogenic Tumors/surgery , Odontogenic Tumors/pathology , Odontogenic Tumors/therapy
7.
J. oral res. (Impresa) ; 3(4): 249-256, dic. 2014. ilus, tab
Article in English | LILACS | ID: lil-776889

ABSTRACT

The keratocystic odontogenic tumor is a benign intraosseous neoplasm derived from remnants of the dental lamina and it occurs with high frequency. Regarding histological characteristics, it has a high recurrence rate which is one of the main therapeutic problems. Also, it presents high local aggressiveness, expressed in cortical expansion, delayed eruption and displacement of teeth, blood vessels and nerves. At present, there are various treatments, being ideal the one which presents the lowest risk of recurrence with low morbidity for the patient. In this review, the main histopathological, clinical and therapeutic aspects of this oral pathology are discussed.


El tumor odontogénico queratoquístico es una neoplasia intraósea benigna que deriva de restos de la lámina dental, y que se presenta con alta frecuencia. Sus características histológicas le confieren una elevada tasa de recidiva, siendo este uno de sus principales problemas terapéuticos. Presenta además una considerable agresividad local, la cual se expresa con la expansión de corticales óseas, retardo en la erupción y desplazamiento de dientes, vasos sanguíneos y nervios. En la actualidad existen diversos tratamientos, siendo el ideal aquel que presente el menor riesgo de recidiva con una baja morbilidad para el paciente. En la presente revisión se discuten los principales aspectos histopatológicos, clínicos y terapéuticos de esta patología oral.


Subject(s)
Humans , Odontogenic Cysts/diagnosis , Odontogenic Cysts/pathology , Odontogenic Tumors/diagnosis , Odontogenic Tumors/pathology , Decompression, Surgical , Diagnosis, Differential , Odontogenic Cysts/surgery , Odontogenic Tumors/surgery
8.
Article in Spanish | LILACS | ID: lil-708827

ABSTRACT

Introducción: Ha sido descrita la inmunodetección de p53 y Ki-67 en el tumor odontogénico queratoquístico (TOQ) y en ameloblastomas mutiquísticos (AM). Sin embargo, hay escasa y contradictoria evidencia respecto de la comparación de estos dos marcadores entre estas neoplasias. Su estudio podría contribuir a comprender las diferencias que presentan en su comportamiento clínico y ser un complemento discriminatorio al momento de definir tratamiento, pronóstico y recidiva. Objetivo: Comparar el recuento de inmunomarcación de p53 y Ki-67 en células epiteliales de TOQ y AM, presentes en el registro de biopsias del Instituto de Referencia de Patología Oral (IREPO), de la Facultad de Odontología de la Universidad de Chile entre los años 2000-2011. Metodología: Estudio observacional de corte transversal. Se estudiaron mediante inmunohistoquímica 8 casos de TOQ y 6 casos de AM con diagnóstico histopatológico según la clasificación de la OMS del 2005. Las muestras se encontraban en bloques de parafina, fijadas en formalina. Resultados: Los datos mostraron una distribución normal en cuanto al número de células positivas para ambos inmunomarcadores. No hubo diferencias estadísticamente significativas en la inmunomarcación de Ki-67 y p53 para TOQ y AM. Sin embargo, en ambas neoplasias, la inmunomarcación de p53 fue mayor respecto a Ki-67, con una diferencia estadísticamente significativa tanto en TOQ (p=0.0134) como en AM (p=0.0079). Conclusión: Los resultados sugieren que la inhibición de apoptosis predominó en ambos tumores por sobre la multiplicación celular. Estas diferencias podrían relacionarse con su potencial de crecimiento.


Introduction: p53 and Ki-67 immunodetection have been described in the keratocystic odontogenic tumor (TOQ) and multicystic ameloblastomas (AM). However, there is limited and contradictory evidence regarding the comparison of these two markers between these neoplasias. Their study could help to understand the differences that occur in their clinical behavior and be a complement when defining discriminatory treatment, prognosis and recurrence. Objective: To compare the immunomarking count of p53 and Ki-67 in epithelial cells in AM and TOQ present in the biopsies registered at the Oral Pathology Reference Institute (IREPO), Faculty of Dentistry, University of Chile from 2000 to 2011. Methods: Cross-sectional observational study. 8 cases of TOQ and 6 cases of AM with histopathological diagnosis according to the WHO classification of 2005 were studied using immunohistochemistry. The samples were formalin-fixed and paraffin-embedded. Results: The data showed a normal distribution in the number of positive cells for both immunomarkers. There were no statistically significant differences in the Immunohistochemical expression of Ki-67 and p53 of TOQ and AM. However in both tumors, the immunohistochemical expression of p53 was higher compared to Ki-67, with a statistically significant difference in TOQ (p=0.0134) and AM (p=0.0079). Conclusion: The results suggest that inhibition of apoptosis in both tumors predominated over cell multiplication. These differences may be related to their growth potential.


Subject(s)
Humans , Ameloblastoma/pathology , Jaw Neoplasms/pathology , Odontogenic Cysts/pathology , Odontogenic Tumors/pathology , Ameloblastoma/metabolism , Biomarkers , Immunohistochemistry , Jaw Neoplasms/metabolism , Odontogenic Cysts/metabolism , Odontogenic Tumors/metabolism
9.
Pakistan Oral and Dental Journal. 2014; 34 (1): 11-17
in English | IMEMR | ID: emr-157654

ABSTRACT

Fifty-two patients of ameloblastoma were operated with special emphasis on radiographic and histological appearance. The unicystic radiographico-histological [38] cases were managed conservatively with marsupialization followed by enucleation [Group A' 15 Patients] and enucleation with peripheral ostectomy [Group B' 23 Patients]. The radiographico-histological multicystic [solid] variety [Group C' 14 Patients] was treated aggressively by resection. In conservative treatment regimens Carnoy's solution was applied after enucleation of the tumour whereas, the patients of aggressive surgery were operated with minimum 5mm safety marginal clearance of the tumour. The recurrence rate with average four years follow up was 0.0% for resection, 13.33% for marsupialization followed by enucleation and 8.69% for enucleation with peripheral ostectomy. The results were encouraging for unicystic ameloblastoma treated patients [Group A' and B'], in best interest of jaw bone contour preservation


Subject(s)
Humans , Male , Female , Ameloblastoma/pathology , Ameloblastoma/diagnostic imaging , Neoplasm Recurrence, Local/pathology , Treatment Outcome , Odontogenic Cysts/pathology , Maxillary Neoplasms/surgery , Mandibular Neoplasms/surgery
10.
Braz. oral res ; 27(6): 496-502, Nov-Dec/2013. tab, graf
Article in English | LILACS | ID: lil-695991

ABSTRACT

The aim of the present study was the morphometric evaluation of the epithelial lining and fibrous capsule in histological specimens of keratocystic odontogenic tumors (KOTs) before and after marsupialization. Histological sections from six KOTs that had undergone marsupialization followed by enucleation were photographed. The thickness and features of the capsule and of the epithelial lining of the tumor were evaluated upon marsupialization and upon subsequent enucleation using Axion Vision software. The histological specimens taken upon marsupialization presented an epithelial lining that is typical of KOTs. After marsupialization, the enucleated specimens had a modified epithelial lining and a fibrous capsule that both presented a greater median thickness (p = 0.0277 and p = 0.0212, respectively), morphological changes, and significant enlargement. These modifications can facilitate full surgical treatment and may well be related to a low KOT recurrence rate.


Subject(s)
Adolescent , Adult , Child , Female , Humans , Male , Young Adult , Jaw Diseases/pathology , Odontogenic Cysts/pathology , Biopsy , Epithelium/pathology , Jaw Diseases/surgery , Odontogenic Cysts/surgery , Recurrence , Statistics, Nonparametric , Time Factors , Treatment Outcome
11.
Full dent. sci ; 4(15): 417-422, June 18, 2013. graf
Article in Portuguese | LILACS, BBO | ID: biblio-850873

ABSTRACT

A presente pesquisa objetivou realizar um levantamento epidemiológico retrospectivo do tumor odontogênico queratocístico no Serviço de Patologia Bucal do Curso de Graduação em Odontologia da Universidade de Fortaleza, no período de novembro de 2001 a março de 2011. Os dados foram coletados pela revisão das fichas de requisição de exame histopatológico e seus respectivos laudos, buscando dados relativos à idade, sexo, raça, localização, tipo de biópsia, associação com dentes inclusos, presença de sintomatologia e hipótese diagnóstica no momento da biópsia. Foram coletados 97 casos, consistindo 14,51% dos cistos odontogênicos neste período. O perfil demográfico encontrado foi formado, na maioria, por pacientes do sexo masculino em 50 casos (48,4%), leucodermas 40 (54%), com idade média de 34,3 anos, variando de 9 a 77, acometendo predominantemente a região posterior da mandíbula em 51 (67,1%), sendo assintomáticos em 52 (72,2%) dos casos


This research aimed to perform a retrospective epidemiological study of keratocystic odontogenic tumor at the Department of Oral Pathology of the Graduate Program in Dentistry, of the Universidade de Fortaleza, from November of 2001 to March 2011.Data were collected through review of histopathology test request form and its reports, searching for data regarding: age, gender, race, location, type of biopsy, association with impacted teeth, presence of symptoms and diagnosis hypothesis in case of biopsy. Ninety seven cases were selected, corresponding to 12.9% of odontogenic cysts collected in this period. The demographic profile was found to be composed mostly of male patients in 50(48.4%), Caucasian 40(54%), with a average age of 34.3 years, ranging from 9 to 77 years , affecting mainly the posterior region of the mandible in 51 patients (67.1%) and asymptomatic in other 52 cases (72.2%)


Subject(s)
Humans , Male , Female , Odontogenic Cysts/diagnosis , Odontogenic Cysts/pathology , Jaw Cysts , Keratins , Odontogenic Tumors/diagnosis , Odontogenic Tumors/pathology , Health Surveys
12.
Odonto (Säo Bernardo do Campo) ; 20(40): 67-72, jul.-dez. 2012. tab, graf
Article in Portuguese | LILACS, BBO | ID: lil-790181

ABSTRACT

Introdução: O Tumor Odontogênico Ceratocístico (TOC) pode ser definido como um tumor intraósseo, benigno, de origem odontogênica. A incidência dessa lesão na mandibula é de 3 a 4 vezes maior que na maxila, com preferência pela região dos terceiros molares inferiores, no ângulo da madíbula, de onde se estende para o ramo ascentende. Em casos de lesões mais extensas, observa-se tumefação, drenagem ou dor associada, aumento de volume de tecidos moles e tecido ósseo, parestesia, mobilidade de dentes envolvidos pela lesão, bem como crescimento lento e deslocamento de peças dentárias. Objetivo e Metodologia: O objetivo deste trabalho foi realizar uma revisão da literatura e um levantamento de casos diagnosticados no Laboratóro de Patologia do Instituto de Ciências Biológicas da UPF a respeito do TOC. Resultados: No presente levantamento, foram encontrados 48 casos de TOC, com uma prevalencia do gênero feminino, na segunda e terceira década de vida. Um maior número de casos ocorreram na mandibula com preferencia pela região de terceiro molar inferior. Apresentavam em sua maioria lesões radiolúcidas uniloculares e o principal sinal clínico foi o de abaulamento. Conclusão: O que pode-se concluir através deste trabalho é que é fundamental para o sucesso do tratamento do Tumor Odontogênico Ceratocístico, o conhecimento por parte do Cirurgião Dentista de lesões tumorais de origem odontogênica , para que um correto e precoce diagnóstico seja executado, levando a melhor escolha do tratamento e, consequentemente um prognóstico favorável.


Introduction: The Keratocystic odontogenic tumor can be defined like an intraosseous tumor, benign, of odontogenic origin. The incidence of this lesion in the mandible and 3 to 4 times higher than in the maxilla, with a preference for the third molar region. In cases of more extensive lesions, there is swelling, drainage or pain associated, swelling of soft tissue and bone tissue, paresthesia, mobility of teeth involved by the injury, as well as slow growth and displacement of dental pieces. Objective and Methodology: The objective of this study was a literature review and a survey of cases diagnosed in the Pathology Lab of the Institute of Biological Sciences, UPF, about keratocystic odontogenic tumor. Result: In this survey, we found 48 cases of TOC, with a prevalence of females in second and third decade of life. A greater number of cases occurred in the jaw with a preference for the third molar region. Had mostly unilocular radiolucent lesions and was the main clinical sign of bulging. Conclusion: What can be concluded from this work is that it is essential for the successful treatment of odontogenic tumor keratocystic, knowledge by the Surgeon Dentist of odontogenic origin tumors, for a correct and early diagnosis is performed, taking the best choice of treatment and thus a favorable prognosis.


Subject(s)
Humans , Male , Female , Child , Adolescent , Young Adult , Middle Aged , Odontogenic Cysts/epidemiology , Odontogenic Cysts/pathology , Odontogenic Tumors/epidemiology , Odontogenic Tumors/pathology , Age Distribution , Brazil/epidemiology , Mandibular Diseases/epidemiology , Mandibular Diseases/pathology , Maxillary Diseases/epidemiology , Maxillary Diseases/pathology , Sex Distribution
14.
Braz. oral res ; 26(4): 330-334, July-Aug. 2012. tab
Article in English | LILACS | ID: lil-640719

ABSTRACT

The purpose of this study was to determine the prevalence of odontogenic cysts and to identify their clinico-pathological features among patients by studying biopsy specimens obtained from the archives of the Department of Oral and Maxillofacial Pathology, College of Dental Sciences, Davangere, Karnataka, India, during the past 10 years. Data for the study were retrieved from the case records of patients fitting the histological classification of the World Health Organization (1992). Analyzed clinical variables included age, gender, anatomical location, and histological diagnosis. Of the 2275 biopsy reports analyzed, 194 cases (8.5%) were jaw cysts, including odontogenic (6.7%) and nonodontogenic cysts (0.25%). Odontogenic cysts included 69.3% radicular, 20.3% dentigerous, 5.2% keratinizing odontogenic, 3.3% residual, and 1.9% other cysts, such as lateral periodontal, botryoid odontogenic, and gingival cysts. The most frequent clinical manifestation was swelling, followed by a combination of pain and swelling. Age, gender, and location were related to the etiopathologic characteristics of the cyst type. A definitive diagnosis can be made on the basis of clinical, radiological, and histological findings, which makes a good interdepartmental relationship between the clinicians and pathologists essential. Knowledge of the biological and histological behavior of the odontogenic cysts is required for their early detection and treatment.


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Middle Aged , Young Adult , Odontogenic Cysts/epidemiology , Odontogenic Cysts/pathology , Age Distribution , Age Factors , Biopsy , India/epidemiology , Mandibular Diseases/epidemiology , Mandibular Diseases/pathology , Maxillary Diseases/epidemiology , Maxillary Diseases/pathology , Prevalence , Sex Distribution
15.
Braz. dent. j ; 23(2): 91-96, Mar.-Apr. 2012. ilus, tab
Article in English | LILACS | ID: lil-626294

ABSTRACT

A high proliferative activity of the odontogenic epithelium in ameloblastoma (AM) and keratocystic odontogenic tumor (KOT) has been demonstrated. However, no previous study has simultaneously evaluated cell proliferation and apoptotic indexes in AM and KOT, comparing both lesions. The aim of this study was to assess and compare cell proliferation and apoptotic rates between these two tumors. Specimens of 11 solid AM and 11 sporadic KOT were evaluated. The proliferation index (PI) was assessed by immunohistochemical detection of Ki-67 and the apoptotic index (AI) by methyl green-pyronine and in situ DNA nick end-labelling methods. KOT presented a higher PI than AM (p<0.05). No statistically significant difference was found in the AI between AM and KOT. PI and AI were higher in the peripheral cells of AM and respectively in the suprabasal and superficial layers of KOT. In conclusion, KOT showed a higher cell proliferation than AM and the AI was similar between these tumors. These findings reinforce the classification of KOT as an odontogenic tumor and should contribute to its aggressive clinical behavior.


Uma elevada atividade proliferativa do epitélio odontogênico em ameloblastoma (AM) e tumor odontogênico ceratocístico (TOC) tem sido demonstrada. Entretanto, não há estudos prévios avaliando simultaneamente os índices de proliferação celular e apoptótico em AM e TOC, comparando ambas as lesões. O objetivo desse estudo foi avaliar e comparar os índices de proliferação celular e apoptótico entre esses dois tumores. Onze amostras deAM sólido e 11 amostras de TOC esporádico foram avaliadas. O índice de proliferação celular foi avaliado por meio da imunomarcação para o antígeno Ki-67 e o índice apoptótico pelas técnicas demetyl-green-pironina e TUNEL. O TOC apresentou um índice de proliferação celular maior que o AM (p<0,05). Nenhuma diferença estatística foi encontrada no índice apoptótico entre AM e TOC. Os índices de proliferação celular e apoptótico foram maiores nas células da camada periférica do AM e, respectivamente, nas camadas suprabasal e superficial do TOC. Em conclusão, o TOC apresentou proliferação celular maior que o AM e o índice apoptótico foi similar entre estes tumores. Estes achados reforçam a classificação do TOC como um tumor odontogênico e podem contribuir para o seu comportamento clínico agressivo.


Subject(s)
Humans , Apoptosis , Ameloblastoma/pathology , Cell Proliferation , Jaw Neoplasms/pathology , Odontogenic Cysts/pathology , Epithelium/pathology , Jaw Diseases/pathology , /analysis
16.
Acta odontol. venez ; 50(1)2012. ilus
Article in Spanish | LILACS | ID: lil-676751

ABSTRACT

El Tumor Odontogénico Quístico Queratinizante (TOQQ) es un tumor benigno de origen odontogénico, el cual fue considerado hasta muy recientemente una lesión quística denominada Queratoquiste odontogénico. El TOQQ es considerado un tumor de estructura quística, sin embargo, debido a su agresivo comportamiento clínico y el alto porcentaje de recurrencia el tratamiento varia desde la enucleación de la lesión hasta la eliminación radical total del hueso afectado. El propósito de este trabajo es la descripción de un caso en paciente femenina de 34 años de edad quien presentó imagen radiolúcida multilocular extensa que ocupó cuerpo y rama mandibular, cuyo estudio histopatológico, previa biopsia incisional, concluyó TOQQ. Se realizó la determinación de Ki-67 mediante inmunohistoquímica para planificar el tratamiento quirúrgico. La baja expresión de Ki-67, a pesar de la extensión de la lesión, fueron los criterios para la realización de tratamiento conservador. La paciente se encuentra sin recidiva después de 5 años de realizado el procedimiento quirúrgico.


Subject(s)
Humans , Adult , Female , /therapeutic use , Surgery, Oral/methods , Odontogenic Cysts/diagnosis , Odontogenic Cysts/pathology , Odontogenic Tumors/diagnosis
17.
Natal; s.n; 2012. 113 p. graf, tab. (BR).
Thesis in Portuguese | LILACS, BBO | ID: lil-642792

ABSTRACT

Os miofibroblastos são células que apresentam um fenótipo híbrido exibindo características morfológicas de fibroblastos e de células musculares lisas, sendo a aquisição de tal fenótipo denominada diferenciação, passando então a expressar a a-SMA, a qual é importante na identificação dessas células. Estudos têm sugerido que os miofibrobíastos apresentam relação com a agressividade de diversas lesões e que o seu processo de diferenciação estaria relacionado à expressão do TGF-pl e do IFN-y atuando, respectivamente, no estímulo e na inibição dessa diferenciação. O objetivo deste trabalho foi investigar o papel dos miofibroblastos em lesões odontogênicas epiteliais, relacionando-os à agressividade das lesões e analisar por meio da imuno-histoquímica. a expressão do TGF-pl e IFN-y no processo de diferenciação, além da análise da MMP-13 que é ativada por miofibroblastos e do indutor de metaloproteinases de matriz (EMMPRIN) como precursor desta MMP. A amostra foi constituída por 20 ameloblastomas sólidos, 10 ameloblastomas unicfsticos, 20 ceratocistos odontogênicos e 20 tumores odontogênícos adenomatóides. Para a avaliação dos miofibroblastos, foram quantificadas as células imunorreativas ao anticorpo a-SMA presentes no tecido conjuntivo, próximo ao tecido epitelial. As expressões de TGF-pl, IFN-y, MMP-13 e EMMPRIN, foram avaliadas no componente epitelial e no conjuntivo, estabelecendo-se o percentual de imunorreatividade e atribuindo-se escores de 0 a 4. A análise dos miofibroblastos evidenciou maior concentração nos ameloblastomas sólidos (média de 30,55), seguido pelos ceratocistos odontogênicos (22,50), ameloblastomas unicísticos (20,80) e tumores odontogênicos adenomatóides (19,15) com valor de p= 0,001. Não foi encontrada correlação significativa entre TGF-pl e IFN-y no processo de diferenciação dos miofibroblastos, bem como na relação entre a quantidade de miofibroblastos e a expressão da MMP-13. Constatou-se, correlação estatística entre MMP-13 e TGF-pi (r= 0,087; p= 0,011) além de significante correlação entre MMP-13 e IFN-y (r=0,348; p=0,003). Entre EMMPRÍN e MMP-13 verificou-se significância (r= 0,474; p<0,001) assim como entre EMMPRIN e IFN-y (r=0,393; p=0,001). A maior quantidade de miofibroblastos evidenciada nos ameloblastomas sólidos, ceratocistos odontogênicos e ameloblastomas unicísticos sugere que estas células podem ser um dos fatores responsáveis para um comportamento biológico mais agressivo destas lesões, embora a população de miofibroblastos não tenha apresentado correlação com TGF- -pi, IFN-y ,MMP-13 e EMMPRIN. Quanto a correlação evidenciada entre MMP-13 e TGF-pl, isto pode sugerir um papel indutor do TGF-pl para a expressão da MMP-13, assim como os resultados deste estudo reforçam a relação bem estabelecida do EMMPRIN como indutor da MMP-13. Constatou-se também relação entre EMMPRIN e IFN-y assim como entre MMP-13 e IFN-y sugerindo, dessa forma, um sinergismo na ação anti-fibrótica desses marcadores.


Myofibroblasts are cells that exhibit a hybrid phenotype, sharing the morphoíogical characteristics of fibroblasts and smooth muscle cells, which is acquired during a process called differentiation. These cells then start to express a-SMA, a marker that can be used for their identification. Studies suggest that myofibroblasts are related to the aggressiveness of different tumors and that TGF-pl and IFN-y play a role in myofibroblast differentiation, stimulating or inhibiting this differentiation, respectively. The objective of this study was to investigate the role of myofibroblasts in epithelial odontogenic tumors, correlating the presence of these cells with the aggressiveness of the tumor. Immunohistochemistry was used to evaluate the expression of TGF-pl and IFN-y in myofibroblast differentiation, as well as the expression of MMP-13, which is activated by myofibroblasts, and of EMMPRIN (extracellular matrix metalloproteinase inducer) as a precursor of this MMP. The sample consisted of 20 solid ameloblastomas, 10 unicystic ameloblastomas, 20 odontogenic keratocysts, and 20 adenomatoid odontogenic tumors. For evaluation of myofibroblasts, anti-a-SMA-immunoreactive cells were quantified in connective tissue close to the epithelium. Immunoexpression of TGF-pl, IFN-y, MMP-13 and EMMPRIN was evaluaíed in the epithelial and connective tissue components, attributing scores of 0 to 4. The results showed a higher concentration of myofibroblasts in solid ameloblastomas (mean of 30.55), followed by odontogenic keratocysts (22.50), unicystic ameloblastomas (20.80), and adenomatoid odontogenic tumors (19.15) (p=0.00). No significant correlation between TGF-pl and IFN-y was observed during the process of myofibroblast differentiation. There was also no correlation between the quantity of myofibroblasts and MMP-13 expression. Significant correlations were found between MMP-13 and TGF-pi (r=0.087; p=0.01 1), between MMP-13 and ÍFN-y (r=0.348; p=0.003), as well as between EMMPRIN and MMP-13 (r=0.474; /xO.001) and between EMMPRIN and IFN-y (r=0.393; p=0.00). The higher quantity of myofibroblasts observed in solid ameloblastomas, odontogenic keratocysts and unicystic ameloblastomas suggests that these cells are one of the factors responsible for the more aggressive biological behavior of these tumors, although the myofibroblast population was not correlated with TGF-01, IFN-y, MMP-13 or EMMPRIN. The correlation between MMP-13 and TGF-pl suggests that the latter induces the expression of this metalloproteinase. The present results also support the well-established role of EMMPRIN as an inducer of MMP-13. Furthermore, the relationship between EMMPRIN and IFN-y and between MMP-13 and IFN-y suggests synergism in the antifibrotic effect of these markers.


Subject(s)
Ameloblastoma/pathology , Odontogenic Cysts/etiology , Odontogenic Cysts/pathology , Extracellular Matrix/pathology , Myofibroblasts/physiology , Myofibroblasts/pathology , Transforming Growth Factors , Odontogenic Tumor, Squamous/diagnosis , Odontogenic Tumor, Squamous/pathology , Immunohistochemistry , Statistics, Nonparametric
18.
Full dent. sci ; 3(9): 99-105, out.-dez. 2011. ilus
Article in Portuguese | LILACS, BBO | ID: lil-642913

ABSTRACT

Cisto periapical é uma cavidade patológica revestidapor epitélio com um lúmen contendo líquidoe restos celulares, que tem por sua origem osrestos epiteliais de Malassez. Possui crescimentolento e assintomático, normalmente não atingindograndes dimensões. Em consequência destalesão, o paciente pode apresentar mobilidadee deslocamento dos dentes adjacentes. Nestetrabalho, os autores realizam uma breve revisãoliterária e o relato de um caso clínico de duplocisto periapical, acometendo paciente do gêneromasculino, negro, 13 anos, estudante de Olinda(PE), que apresentava um aumento de volumena hemiface esquerda. Na anamnese, referiuque o aumento de volume teve início há cercade 2 anos, mas como não havia queixa de dor oproblema foi relevado. Ao exame extra-bucal, opaciente apresentava deformidade na hemifaceesquerda com sob-elevação da asa do nariz esquerda,sem evidências de hipertermia ao toque.Ao exame intra-bucal, apresentava aumento devolume na região dos elementos 21 e 25. Radiograficamente,evidenciaram-se duas enormeslesões do tipo císticas relacionadas com o ápicedos elementos 21 e 25. O exame histopatológicoda peça operatória confirmou em definitivo odiagnóstico de cistos periapicais.


Periapical cyst is a pathological socket coatedby epithelium with liquid and cellular remainingportions lumen that has for its originthe Malassez epithelial remaining portions. Itpresents slow and assintomatic growth, normallynot reaching big dimensions. In consequenceof this injury, the patient may presentadjacent teeth mobility and displacement.In this work, the authors carry through onebrief literary revision and the history of a clinicalcase of double periapical cyst attemptinga male black patient, 13 years old, student,from Olinda (PE), that presented a volumeincrease in left hemiface. In anamnesis, hisgenitor mentioned that the volume increasehad beginning about 2 years, but as it didnot have pain complaint, they had raised theproblem. In extra-buccal examination, thepatient presented deformity in left hemifacewith under-rise of left nose wing, withouthyperthermia evidence on touch. In intrabuccalexamination, he presented volumeincrease of 21 and 25 elements region. Thex-ray examination showed two enormouscystic injuries related with 21 and 25 apex.The histopathological examination definitivelyconfirmed the periapical cysts diagnosis.


Subject(s)
Humans , Adolescent , Radicular Cyst/pathology , Odontogenic Cysts/diagnosis , Odontogenic Cysts/pathology , Surgery, Oral , Radiography, Panoramic/methods
19.
Int. j. odontostomatol. (Print) ; 5(3): 227-234, dic. 2011. ilus
Article in English | LILACS | ID: lil-612094

ABSTRACT

The aim was to review previous cases of Odontogenic Keratocyst or Keratocystic Odontogenic Tumor according to the new WHO classification. We used all cases diagnosed as Odontogenic Keratocyst or Keratocystic Odontogenic Tumor registered in the archives of the Pathologic Anatomy Laboratory of the Department of Pathology and Oral Diagnosis of the School of Dentistry of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, which were collected from September, 1983 until September, 2008. The terms “Keratocyst” or “Keratocystic Odontogenic Tumor” were searched for and the following data were collected from the case files: age, sex, location of the lesion(s), and patients’ chief complaints. Hematoxilin and Eosin slides were reviewed according to the 2005 WHO criteria. The results found are in accordance with the literature. Due to its benign features, the Orthokeratinized Odontogenic Keratocyst found in our sample had its diagnosis changed to Orthokeratinized Odontogenic Cyst, as recommended by the WHO. Histopathologic exams are required for every bone lesion, in order to establish correct diagnosis. Because of its features, the Keratocystic Odontogenic Tumor must have more aggressive treatment, compared with odontogenic cysts, and long-term follow-up is mandatory.


El objetivo fue revisar los casos anteriores de queratoquiste odontogénico (QO) o tumor odontogénico queratoquístico (TOQ) de acuerdo con la nueva clasificación de la OMS. Fueron utilizados todos los casos diagnosticados como QO o TOQ registrados en los archivos del Laboratorio de Anatomía Patológica del Departamento de Patología y Diagnóstico Oral de la Facultad de Odontología de la Universidad Federal de Río de Janeiro, Rio de Janeiro, Brasil, registrados a partir de septiembre de 1983 hasta septiembre del 2008. Los términos "Queratoquiste" o "tumor queratoquistes odontogénicos" se buscaron y los siguientes datos se obtuvieron de los archivos del caso: edad, sexo, localización de la lesión (es), y quejas de los pacientes. Las muestras histológicas de hematoxilina y eosina fueron revisadas de acuerdo a los criterios de la OMS 2005. Los resultados encontrados estaban de acuerdo con la literatura. Debido a sus características benignas, el queratoquiste odontogénico ortoqueratinizado encontrado en nuestra muestra había cambiado su diagnóstico de quiste odontogénico ortoqueratinizado, según lo recomendado por la OMS. Los exámenes histopatológicos son necesarios para toda lesión ósea, con el fin de establecer el diagnóstico correcto. Debido a sus características, el TOQ debe tener un tratamiento más agresivo, en comparación con los quistes odontogénicos, donde un seguimiento a mediano y largo plazo es obligatorio.


Subject(s)
Humans , Male , Adult , Female , Child, Preschool , Child , Middle Aged , Odontogenic Cysts/epidemiology , Odontogenic Cysts/pathology , Odontogenic Tumors/epidemiology , Odontogenic Tumors/pathology , Age and Sex Distribution , Brazil , Retrospective Studies
20.
Odonto (Säo Bernardo do Campo) ; 19(37): 25-32, jan.-jun.2011. ilus
Article in English | LILACS | ID: lil-789947

ABSTRACT

The keratocystic odontogenic tumor (KOT) is a relatively common oral and maxillofacial lesion that arises from rests of dental lamina. It has an agressive behavior including high rates of recurrence, rapid growth, and extension into adjacent tissues. Various treatment modalities, and thus differing recurrence rates after treatment, have been reported. Due to the very thin and friable lining, characteristic of the tumor, enucleation can be difficult undertaking and, for this reason it is associated with the highest recurrence rates.Aim: we describe a case of a large KOT in the mandibular body, where due to the presence of an unusual thick lining, removal of the tumor as a single piece was sucessful.Conclusion: this case shows that large KOT can be treated in a conservative approach. Due to the possible recurrences many years after initial treatment, a life-long follow-up schedule is mandatory...


O tumor odontogênico ceratocístico (TOC) é uma lesão oral e maxilofacial relativamente comum que surge de restos da lâmina dental. Ele tem um comportamento agressivo, incluindo altas taxas de recorrência, crescimento rápido e extensão para os tecidos adjacentes. Várias modalidades de tratamento e, assim, diferentes taxas de recorrência após o tratamento, foram relatadas. Devido ao revestimento muito fino e friável, característica do tumor, a enucleação pode ser difícil e, por esta razão ele é associado com as maiores taxas de recorrência. Objetivo: o presente trabalho descreve um caso de um grande TOC no corpo mandibular, onde, devido à presença de um revestimento de espessura incomum, a remoção do tumor como uma peça única foi bem sucedida. Conclusão: o presente caso demonstra que TOC de grandes proporções podem ser tratados de maneira conservadora. Devido à possibilidade de recidiva em muitos anos após o tratamento inicial, acompanhamento a longo prazo é obrigatório...


Subject(s)
Humans , Male , Middle Aged , Odontogenic Cysts/surgery , Odontogenic Cysts/pathology , Mandibular Diseases/surgery , Mandibular Diseases/pathology , Odontogenic Cysts , Mandibular Diseases , Radiography, Panoramic , Treatment Outcome
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