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1.
Rev. cuba. estomatol ; 58(3): e3172, 2021. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347439

ABSTRACT

Introducción: El ameloblastoma es un tumor odontogénico epitelial benigno con tendencia a la recurrencia local si no se elimina adecuadamente. Las alternativas reconstructivas incluyen el uso de colgajos libres microvascularizados, placas y prótesis personalizada de titanio. Objetivo: Describir un reemplazo hemimandibular con prótesis personalizada de titanio posterior a la exéresis de ameloblastoma. Presentación del caso: Mujer de 44 años de edad, que presentó un hallazgo radiográfico durante la realización de tratamiento pulporradicular del diente número 37. Al realizársele el reconocimiento físico facial mostró aumento de volumen en región geniana izquierda mientras que el examen intrabucal detectó expansión de las corticales en la arcada posteroinferior del mismo lado. Se realizó una radiografía panorámica y tomografía axial computarizada con la que se constató la presencia de imagen radiolúcida, multiloculada, en forma de "pompas de jabón" extendiéndose desde el cuerpo mandibular hasta el cóndilo del lado izquierdo. Se tomó muestra para biopsia, con la cual se constató que se trataba de ameloblastoma con patrón folicular. Se realizó abordaje cervical, segmentaria mandibular con margen de seguridad y exarticulación. Se reemplazó la porción eliminada con prótesis personalizada de titanio. Se mantuvo el chequeo posoperatorio en el que se comprobó una buena evolución. Conclusiones: La cirugía constituyó el pilar de tratamiento utilizado. Una vez realizada la resección quirúrgica se reconstruyó el defecto con prótesis personalizada de titanio, proceder de gran novedad en nuestro medio y útil para restablecer la función y estética(AU)


Introduction: Ameloblastoma is a benign tumor of odontogenic epithelium with a tendency to local recurrence if not removed appropriately. Reconstruction alternatives include the use of microvascularized free flaps, plates and customized titanium prostheses. Objective: Describe a case of mandibular replacement with a customized titanium prosthesis after ameloblastoma excision. Case presentation: A case is presented of a female 44-year-old patient who presented a radiographic finding during pulporadicular treatment of tooth 37. Facial physical examination found an increase in volume in the left genian region, and intraoral observation detected expansion of the corticals in the lower posterior arch of the same side. Panoramic radiography and computed axial tomography showed a multilocular radiolucid image resembling soap bubbles which extended from the mandibular body to the left condyle. A sample was taken for biopsy, which confirmed the diagnosis of follicular pattern ameloblastoma. Segmental mandibular surgery was performed by cervical approach with a safety margin and exarticulation. The portion removed was replaced with a customized titanium prosthesis. Post-operative control showed a good evolution. Conclusions: Surgery was the basic component of the treatment applied. Surgical resection was followed by reconstruction of the defect with a customized titanium prosthesis, a procedure of great novelty in our environment useful to restore function and esthetic appearance(AU)


Subject(s)
Humans , Female , Adult , Titanium/adverse effects , Biopsy/adverse effects , Ameloblastoma/diagnostic imaging , Odontogenic Tumors/surgery , Mandibular Reconstruction/methods , Radiography, Panoramic
2.
Rev. Asoc. Odontol. Argent ; 109(2): 119-123, ago. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1348424

ABSTRACT

Objetivo: Presentar el caso de una patología poco común como es el fibro-odontoma ameloblástico (FOA), su manejo interdisciplinario y su resolución quirúrgica. Caso clínico: En este reporte de caso describimos un FOA en una paciente de 10 años, ubicado en el cuerpo mandibular derecho, asociado a las raíces de molares temporales que generó la retención de premolares. Se realizó la enucleación completa de la lesión, exodoncia de los temporales asociados y se decidió mantener los dientes definitivos y esperar su erupción espontánea. Es importante considerar la posibilidad de mantener el diente retenido si este no dificulta la exéresis de la lesión, ya sea para su erupción espontánea o rescate ortodóntico, lo cual es posible observar en este caso en el que se aprecia una evolución intraósea favorable. Con respecto al seguimiento, se recomienda el control a largo plazo con el fin de controlar la erupción del órgano dentario o la aparición de posibles recidivas (AU)


Aim: To present a clinical case of a rare pathology, the ameloblastic fibro odontoma (AFO), its interdisciplinary management and its surgical resolution. Clinical case: In this case report we describe an AFO in a 10-years-old patient, localized in the right hand side of the body of the mandible, associated with the roots of temporary molars that generated the retention of the premolars. Complete enucleation of the lesion and the extraction of the associated temporary molars were performed. It was decided to keep the permanent teeth and to wait for their spontaneous eruption. It is important to consider the possibility of keeping the retained teeth if it does not hinder the excision of the lesion, either for its spontaneous eruption or orthodontic rescue, which is possible to see in this case, in which a favorable intraosseous evolution is appreciated. With regard to follow-up, long-term monitoring is recommended in order to control the eruption of the dental organ or the appearance of possible recurrences (AU)


Subject(s)
Humans , Female , Child , Odontogenic Tumors , Odontoma/surgery , Schools, Dental , Tooth Extraction , Tooth, Impacted , Bicuspid , Biopsy , Chile , Histological Techniques , Oral Surgical Procedures , Molar
3.
Braz. dent. j ; 32(4): 74-82, July-Aug. 2021. tab, graf
Article in English | LILACS, BBO | ID: biblio-1345513

ABSTRACT

Abstract The Inhibitor of Growth (ING) gene family is a group of tumor suppressor genes that play important roles in cell cycle control, senescence, DNA repair, cell proliferation, and apoptosis. However, inactivation and downregulation of these proteins have been related in some neoplasms. The present study aimed to evaluate the immunohistochemical profiles of ING3 and ING4 proteins in a series of benign epithelial odontogenic lesions. Methods: The sample comprised of 20 odontogenic keratocysts (OKC), 20 ameloblastomas (AM), and 15 adenomatoid odontogenic tumors (AOT) specimens. Nuclear and cytoplasmic immunolabeling of ING3 and ING4 were semi-quantitatively evaluated in epithelial cells of the odontogenic lesions, according to the percentage of immunolabelled cells in each case. Descriptive and statistics analysis were computed, and the p-value was set at 0.05. Results: No statistically significant differences were found in cytoplasmic and nuclear ING3 immunolabeling among the studied lesions. In contrast, AOTs presented higher cytoplasmic and nuclear ING4 labeling compared to AMs (cytoplasmic p-value = 0.01; nuclear p-value < 0.001) and OKCs (nuclear p-value = 0.007). Conclusion: ING3 and ING4 protein downregulation may play an important role in the initiation and progression of more aggressive odontogenic lesions, such as AMs and OKCs.


Resumo Objetivos: A família dos Genes Inibidores de Crescimento (ING) é um grupo de genes supressores tumorais que desempenham papéis importantes no controle do ciclo celular, na senescência, no reparo do DNA, na proliferação celular e na apoptose. No entanto, a inativação e a regulação negativa dessas proteínas têm sido relacionadas em algumas neoplasias. O objetivo do presente estudo foi avaliar o perfil imuno-histoquímico das proteínas ING3 e ING4 em uma série de lesões odontogênicas epiteliais benignas. Métodos: A amostra foi composta por espécimes de 20 ceratocistos odontogênicos (CO), 20 ameloblastomas (AM) e 15 tumores odontogênicos adenomatoides (TOA). A imunoexpressão nuclear e citoplasmática de ING3 e ING4 foram avaliadas semi-quantitativamente nas células epiteliais das lesões odontogênicas, de acordo com a porcentagem de células imunomarcadas em cada caso. As análises descritivas e estatísticas foram computadas, e o valor de p estabelecido foi de 0,05. Resultados: Não foram encontradas diferenças estatisticamente significativas na imunoexpressão citoplasmática e nuclear de ING3 entre as lesões estudadas. Em contrapartida, os TOAs apresentaram maior marcação citoplasmática e nuclear de ING4 em comparação aos AMs (valor de p citoplasmático=0,01; valor de p nuclear <0,001) e COs (valor nuclear de p=0,007). Conclusão: A regulação negativa das proteínas ING3 e ING4 pode desempenhar um papel importante na iniciação e na progressão de lesões odontogênicas mais agressivas, como AMs e COs.


Subject(s)
Humans , Ameloblastoma , Odontogenic Cysts , Odontogenic Tumors , Homeodomain Proteins , Cell Cycle Proteins , Tumor Suppressor Proteins , Cell Proliferation
4.
Odontol. Clín.-Cient ; 20(1): 85-89, jan.-mar. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1368451

ABSTRACT

O odontoma é uma alteração definida como um tumor odontogênico benigno e representa cerca de 70% das ocorrências dos tumores odontogênicos. O objetivo desse estudo foi apresentar um caso clínico referente ao diagnóstico e tratamento de um odontoma complexo em região anterior de maxila. Paciente de 27 anos compareceu à clínica buscando avaliação de rotina e, ao exame clínico, foi verificada a ausência dos elementos dentais 13 e 14 e retenção prolongada do 54. Radiograficamente, foi observada a presença de uma lesão radiopaca sugestiva de odontoma complexo, além de impactação dos elementos dentais 13 e 14. A abordagem adotada foi a remoção da lesão, do elemento 54 e tracionamento ortodôntico do elemento 13. A cirurgia foi feita em ambiente ambulatorial, sob anestesia local, iniciando pela exodontia do elemento 54, logo depois foi feita a incisão de Newman, descolamento mucoperiostal e remoção da lesão com broca cirúrgica esférica em alta rotação, sob refrigeração abundante com soro fisiológico estéril. Posteriormente, foi acessado o elemento 13 por vestibular e feito o desgaste ósseo com broca cirúrgica esférica, até a exposição da coroa do dente. Por fim, foi realizada a colagem do dispositivo de tracionamento ortodôntico, botão associado a fio de aço colocado com resina composta e o paciente foi encaminhado ao ortodontista. O diagnóstico e tratamento desse tipo de patologia é de suma importância, evitando implicações estéticas e funcionais ao paciente. Não é comum recorrências, e tem prognóstico excelente... (AU)


Odontoma is an alteration defined as a benign odontogenic tumor and represents about 70% of the oc currences of odontogenic tumors. The aim of this study was to present a clinical case regarding the diag nosis and treatment of a complex odontoma in the anterior region of the maxilla. A 27-year-old patient came to the clinic seeking routine evaluation and, on clinical examination, the absence of dental elements 13 and 14 and prolonged retention of 54 were verified. Radiographically, the presence of a radiopaque lesion suggestive of a complex odontomawas observed, in addition to impaction of dental elements 13 and 14. The approach adopted was the removal of the lesion, element 54 and orthodontic traction of element 13. The surgery was performed in an outpatient setting, under local anesthesia, starting with the extraction of element 54, shortly afterwards Newman's incision, mucoperiosteal detachment and removal of the lesion with a high-speed spherical surgical drill, under abundant refrigeration with sterile saline. Subsequently, element 13 was accessed through the vestibular and bone wear was done with a spherical surgical drill, until the tooth crown was exposed. Finally, the orthodontic traction device was bonded, a button associated with steel wire placed with composite resin and the patient was referred to the ortho dontist. The diagnosis and treatment of this type of pathology is extremely important, avoiding aesthetic and functional implications for the patient. Recurrences are not common and have an excellent prognosis... (AU)


Subject(s)
Humans , Male , Adult , Tooth Abnormalities , Odontogenic Tumors , Odontoma , Mouth Neoplasms
5.
Odontol. Clín.-Cient ; 20(1): 94-98, jan.-mar. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1368709

ABSTRACT

O Granuloma central de células gigantes é próprio dos ossos gnáticos, sendo um tumor benigno não odontogênico. É uma lesão de crescimento normalmente lento, bem circunscrito e assintomático, geralmente diagnosticado através de algum exame de rotina ou, em casos mais avançados, quando se começa a visualizar alguma alteração estético-anatômica. O tratamento de eleição para este tipo de lesão é a simples curetagem ou a ressecção em bloco. No entanto, em pacientes adultos jovens e em crianças, o efeito mutilante que este tipo de tratamento pode acarretar deve ser levado em consideração, utilizando tratamentos não cirúrgicos, como injeção intralesional de corticosteroides, administração de interferon alpha e calcitonina. Assim, o objetivo deste trabalho é relatar um caso de tratamento com ressecção segmentar de granuloma central de células gigantes. Tumores mais agressivos e recorrentes devem ser submetidos à ressecção e mesmo assim deve se levar em consideração o efeito estético que pode causar na face do paciente, principalmente, se forem crianças e adultos jovens... (AU)


The central granuloma of giant cells is specific to gnathic bones, being a benign non-odontogenic tumor. It's a growth injury usually slow, well circumscribed and asymptomatic, usually diagnosed through some routine examination or, in more advanced cases, when it begins to visualize some aesthetic-an atomical alteration. The treatment of choice for this type of injury is a simple curettage or resection in block. However, in young adult patients and children, the mutilating effect that this type of treatment can bring must be taken in to consideration, using non-surgical treatments, such as intralesional injection of corticosteroids, administration of alpha interferon and calcitonin. Therefore, the objective of this work is to report a case of treatment with resection segment of central granuloma of giant cells. More aggressive and recurrent tumors must be submitted to resection and even then taking into account the aesthetic effect it can have on the patient's face, especially if they are children and young adults... (AU)


Subject(s)
Humans , Female , Adult , Granuloma, Giant Cell , Odontogenic Tumors , Giant Cells , Adrenal Cortex Hormones , Neoplasms
6.
Rev. medica electron ; 43(2): 3239-3248, mar.-abr. 2021. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1251941

ABSTRACT

RESUMEN El ameloblastoma es un tumor odontogénico benigno, localmente agresivo y recidivante, con predilección por la región posterior de la mandíbula. Se caracteriza por su agresividad local con muy baja tendencia a metastizarse. El objetivo fue reportar el caso clínico de un paciente con ameloblastoma multiquístico derecho, tratado a través de hemimandibulectomía. Se presentó un paciente masculino, de 44 años de edad, que refirió aumento de volumen del lado derecho de la mandíbula desde hacía aproximadamente un año, acompañado también de otros síntomas, atendido en el Servicio de Cirugía Maxilofacial del Hospital Militar Principal/Instituto Superior, en Luanda, Angola. Los estudios imagenológicos incluyeron radiografía panorámica y tomografía axial computarizada. El diagnóstico clínico patológico fue de ameloblastoma multiquístico. Este tipo de tumor requiere de un adecuado diagnóstico sobre la base de la presentación clínica, localización, tamaño, edad y tipo histológico; de ahí la importancia de conocer las características clínicas e imagenológicas, pues el tratamiento conlleva gran dificultad (AU).


ABSTRACT Ameloblastoma is a benign odontogenic tumor, locally aggressive and recidivist with predilection for back of the jaw, characterized by local aggressiveness and low tendency to metastasize. The aim was reporting the clinical case of a patient with right multicystic ameloblastoma treated through hemimandibulectomy. We presented a male patient aged 44 years, who referred a volume increase of the jaw right side for around a year, accompanied also by other symptoms; he attended the Maxillofacial Surgery Service of the Main Military Hospital/High Institute of Luanda, in Angola. The image studies included panoramic radiography and computerized axial tomography the clinical pathological diagnosis was multicystic ameloblastoma. This kind of tumor requires an adequate diagnosis based on the clinical presentation, location, size, age and histological kind, therefore the importance of knowing the clinical and image characteristics, because the treatment is very difficult (AU).


Subject(s)
Humans , Male , Adult , Ameloblastoma/surgery , Mandibular Osteotomy/methods , Biopsy/methods , Ameloblastoma/complications , Ameloblastoma/diagnosis , Mandibular Diseases/diagnosis , Odontogenic Tumors/surgery , Odontogenic Tumors/diagnosis , Clinical Diagnosis
7.
Braz. dent. j ; 32(1): 16-25, Jan.-Feb. 2021. tab, graf
Article in English | LILACS, BBO | ID: biblio-1180723

ABSTRACT

Abstract The aim of this study was to assess and compare RANK, RANKL, and OPG immunoexpression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma. The protocol was registered in PROSPERO (CRD42018105543). Seven databases (Embase, Lilacs, LIVIVO, PubMed, Scopus, SciELO, and Web of Science) were the primary search sources and two databases (Open Grey and Open Thesis) partially captured the "grey literature". Only cross sectional studies were included. The JBI Checklist assessed the risk of bias. A meta-analysis with random effects model estimated the values from the OPG and RANKL ratio reported by the individual studies and respective 95% confidence intervals. The heterogeneity among studies was assessed with I2 statistics. Only nine studies met the inclusion criteria and were considered in the analyses. The studies were published from 2008 to 2018. Two studies presented low risk of bias, while seven studies presented moderate risk. The meta-analysis showed the highest OPG>RANKL ratio for dentigerous cyst (ES=43.3%; 95% CI=14.3-74.8) and odontogenic keratocyst (ES=36.8%; 95% CI=18.8-56.7). In contrast, the highest OPG<RANKL ratio was found for ameloblastoma (ES=73.4%; 95% CI=55.4-88.4) and it was higher in the stromal region compared to the odontogenic epithelial region. The results may explain the aggressive potential of ameloblastoma from the higher OPG<RANKL ratio in this tumor, while it was lower for dentigerous cyst and odontogenic keratocyst.


Resumo O objetivo deste estudo foi avaliar e comparar a imunoexpressão de RANK, RANKL e OPG em cisto dentígero, ceratocisto odontogênico e ameloblastoma. O protocolo foi registrado no PROSPERO (CRD [Oculto]). Sete bancos de dados (Embase, Lilacs, LIVIVO, PubMed, Scopus, SciELO e Web of Science) foram as principais fontes de pesquisa e duas bases de dados (Open Grey e Open Thesis) capturaram parcialmente a "literatura cinza". Apenas estudos transversais foram incluídos. A ferramenta JBI avaliou o risco de viés. Uma metanálise com modelo de efeitos aleatórios estimou os valores da razão OPG e RANKL relatados pelos estudos individuais e seus respectivos intervalos de confiança de 95%. A heterogeneidade entre os estudos foi avaliada por meio do teste I2. Apenas nove estudos preencheram os critérios de inclusão e foram considerados nas análises. Os estudos foram publicados entre 2008 e 2018. Dois estudos apresentaram baixo risco de viés, enquanto sete estudos apresentaram risco moderado. A meta-análise mostrou a maior razão OPG> RANKL para cisto dentígero (ES=43,3%; IC95%=14,3-74,8) e ceratocisto odontogênico (ES=36,8%; IC95%=18,8-56,7). Por outro lado, a maior razão OPG <RANKL foi encontrada para ameloblastoma (ES=73,4%; IC95%=55,4-88,4) e foi maior na região estromal em comparação com a região epitelial odontogênica. Os resultados podem explicar o potencial agressivo do ameloblastoma devido a uma maior proporção OPG <RANKL nesse tumor, enquanto tal proporção foi menor no cisto dentígero e no ceratocisto odontogênico.


Subject(s)
Humans , Ameloblastoma , Dentigerous Cyst , Odontogenic Cysts , Odontogenic Tumors , Cross-Sectional Studies
8.
Article in English | WPRIM | ID: wpr-921399

ABSTRACT

Peripheral odontogenic keratocysts are rarely observed, and cases of odontogenic keratocysts of buccal soft tissues are even rarer. This study was performed to present two rare cases of odontogenic keratocysts in buccal soft tissues and review related literature.


Subject(s)
Humans , Odontogenic Cysts/diagnosis , Odontogenic Tumors
9.
Rev. Ateneo Argent. Odontol ; 64(1): 44-50, 2021. ilus, graf
Article in Spanish | LILACS | ID: biblio-1252537

ABSTRACT

RESUMENObjetivo: el objetivo de este estudio fue identificar la prevalencia, ubicación y diagnóstico histopatológico de las lesiones radiolúcidas presentes en las radiografías panorámicas de pacientes que concurrieron a la cátedra de Cirugía y Traumatología Bucomaxilofacial I de la Facultad de Odontología de la Universidad de Buenos Aires, cuando el motivo de consulta no coincidió con el hallazgo radiográfico.Métodos: se realizó un análisis retrospectivo, observacional y descriptivo que consistió en identificar las imágenes radiolúcidas mayores a 1 cm de diámetro y presentes en radiografías panorámicas a partir de la revisión de historias clínicas de pacientes que concurrieron y fueron tratados quirúrgicamente en la cátedra de Cirugía y Traumatología Bucomaxilofacial I desde marzo de 2014 a diciembre de 2019. A partir de dichas historias clínicas, se registró edad y género del paciente, ubicación de la lesión en el maxilar, asociación o no a una pieza dentaria y resultado anatomopatológico.Resultados: los resultados AP se asociaron significativamente con los rangos etarios, no así con los sectores de piezas, ni con el sexo (AU)


Objective: the objective of this study was to identify the prevalence, location and histopathological diagnosis of radiolucent lesions present in the panoramic radiographs of patients who attended the chair of Bucomaxillofacial Surgery and Traumatology I, when the reason for consultation did not coincide with the radiographic finding.Methods: a retrospective, observational and descriptive analysis was carried out that consisted of identifying radiolucent images larger than 1 cm diameter present in panoramic radiographs from the review of medical records of patients who attended and were treated surgically in the chair of Bucomaxillofacial Surgery and Traumatology I from March 2014 to December 2019. From these medical records, the age and gender of the patient, location of the lesion in the maxilla, its association or not with a tooth, and pathological results were recorded.Results: the anatomopathological results were significantly associated with the age ranges, not with the sectors of pieces or with sex.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Jaw Diseases/epidemiology , Jaw Diseases/diagnostic imaging , Odontogenic Cysts/diagnostic imaging , Odontogenic Tumors/diagnostic imaging , Argentina/epidemiology , Schools, Dental , Biopsy/methods , Radiography, Panoramic , Epidemiology, Descriptive , Retrospective Studies , Histological Techniques , Age Distribution , Observational Study
10.
Rev. cir. traumatol. buco-maxilo-fac ; 20(1): 39-42, jan.-mar. 2020. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1253598

ABSTRACT

Introdução: O ameloblastoma é um tumor odontogênico benigno, embora seja localmente agressivo. As modalidades de tratamento para o ameloblastoma podem ser classificadas em radicais ou conservadoras, contudo a determinação da técnica de eleição permanece um tema controverso. Este trabalho tem como objetivo relatar e discutir um caso de ameloblastoma recorrente, tratado de forma conservadora, com enucleação e curetagem em um indivíduo adolescente. Relato do Caso: Paciente, sexo masculino, de 12 anos, foi encaminhado ao serviço de CTBMF do Hospital Universitário Oswaldo Cruz com aumento de volume assintomático em região de parassínfise mandibular direita. Foi realizada biópsia incisional e obtido o diagnóstico de ameloblastoma. Após dois anos de descompressão, foi realizada enucleação com curetagem da lesão. Cinco anos após a intervenção, o paciente apresentou recidiva do tumor, sendo realizada nova abordagem conservadora. Em acompanhamento de sete meses, ele evoluiu assintomático e sem sinais de recidiva. Considerações Finais: A abordagem conservadora é uma alternativa viável no tratamento de ameloblastomas, em especial quando se trata de indivíduos jovens, entretanto esta deve ser seguida de um rigoroso protocolo de acompanhamento clínico e radiográfico pós-operatório... (AU)


Introduction: The ameloblastoma is a benign but localy agressive odontogenic tumour. The modalities of treatment for ameloblastoma can be classified as radical or conservative, although the determination of the preferred technique remains a controversial field. The objective of this study is to report and discuss a case of recurrent ameloblastoma treated with a conservative approach with enucleation and curettage in a young patient. Case Report: 12-years old man, referred to the service of oral and maxillofacial surgery of Oswaldo Cruz University Hospital with an asymptomatic swelling in the right mandibular parasymphysis. Incisional biopsy was performed and the diagnosis of ameloblastoma was obtained. After two years of decompression, enucleation and curettage of the lesion were performed. Five years after the intervention, the patient presented with recurrence of the tumour and a new conservative approach was performed. In a seven month follow-up, the patient presents asymptomatic and without signs of recurrence. Final Considerations: The conservative approach is a viable option in the treatment of ameloblastomas, especially in young individuals. However, it should be followed by a strict protocol of clinical and radiographic postoperative follow-up... (AU)


Subject(s)
Humans , Male , Child , Surgery, Oral , Ameloblastoma , Odontogenic Tumors , Conservative Treatment , Wounds and Injuries
11.
Rev. cuba. estomatol ; 57(2): e2448, abr.-jun. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126509

ABSTRACT

RESUMEN Introducción: La malignización de quiste dentígero a carcinoma intraóseo primario es infrecuente, poco documentada en la literatura. Corresponde del el 1 por ciento al 2,5 por ciento del total de tumores odontogénicos y es exclusiva de los huesos maxilares. Más común en hombres sobre 50 años de edad. Las características clínicas se asocian a edema, movilidad de piezas dentarias, parestesia, y la mayoría ocurre en ausencia de dolor, características que hacen difícil su diagnóstico y presentan un desafío para los patólogos. Objetivo: Revisar la prevalencia de carcinoma intraóseo primario derivados de quiste dentígero en los últimos 15 años publicados en PubMed Métodos: Se realizó una revisión de la literatura en un periodo que considera los últimos 15 años. Se consultó la base de datos PubMed utilizando los términos: "dentigerous cyst prevalence", "primary intraosseous squamous cell carcinoma", "dentigerous primary intraosseous squamous cell carcinoma". Se incluyeron artículos en inglés y español. De los 217 artículos, se suscribió a 39 para hacer el cruce de datos. Análisis e integración de los resultados: Para reconocer una enfermedad tan agresiva como el carcinoma intraóseo primario derivado de quiste dentígero hay que estudiar sus características clínicas, radiográficas y sintomatología. Su íntima relación con el quiste dentígero, el cual es el más prevalente de los quistes del desarrollo hace fundamental el profundo conocimiento de ambos. El carcinoma intraóseo primario se presenta como un desafío para los clínicos por su baja sintomatología y pobre sobrevida, con un total de 44 823 quistes odontogénicos estudiados, 9806 se diagnosticaron como quistes dentígeros, y 22 se malignizaron a carcinoma intraóseo primario, para un 0,32 por ciento del total. Conclusiones: La malignización de quiste dentígero a carcinoma intraóseo primario tiene una baja incidencia, pero se presenta silente haciendo difícil su diagnóstico precoz. Se recomienda biopsia de protocolo para cada caso de quiste dentígero y así evitar la baja sobrevida que produce el carcinoma intraóseo primario(AU)


ABSTRACT Introduction: Malignancy of dentigerous cyst into primary intraosseous carcinoma is infrequent and scantily documented in the literature. It represents 1 percent to 2.5 percent of the total odontogenic tumors and is exclusive of maxillary bones. It is more common among men aged around 50 years. Its clinical characteristics are edema, tooth mobility and paresthesia, and in most cases an absence of pain. These features hamper its diagnosis and pose a challenge to pathologists. Objective: Review the prevalence of primary intraosseous carcinoma derived from dentigerous cysts as published in PubMed in the last 15 years. Methods: A literature review was conducted of papers published in the last 15 years. The database PubMed was consulted using the following search terms: "dentigerous cyst prevalence", "primary intraosseous squamous cell carcinoma", "dentigerous primary intraosseous squamous cell carcinoma". The papers included were in English or Spanish. Of the 217 papers obtained, 39 were selected for data crossing. Data analysis and integration: Recognition of a condition as aggressive as primary intraosseous carcinoma derived from a dentigerous cyst requires examination of its clinical and radiographic characteristics as well as its symptoms. Its close relationship to dentigerous cyst, the most prevalent of developmental cysts, makes it necessary to gain an accurate and deep understanding of both. Primary intraosseous carcinoma poses a challenge to clinicians due to its low symptomatology and poor survival. Of the total 44 823 odontogenic cysts studied, 9 806 were diagnosed as dentigerous cysts and 22 maligned into primary intraosseous carcinoma, for 0.32 percent of the total. Conclusions: Malignation of a dentigerous cyst into primary intraosseous carcinoma has a low incidence and a silent presentation, which hampers its early diagnosis. Protocol biopsy is recommended for each case of dentigerous cyst to prevent the poor survival caused by primary intraosseous carcinoma(AU)


Subject(s)
Humans , Dentigerous Cyst/pathology , Odontogenic Cysts/epidemiology , Odontogenic Tumors/epidemiology , Early Diagnosis , Survival , Review Literature as Topic , Databases, Bibliographic
12.
Medisan ; 24(3)mayo.-jun. 2020. ilus
Article in Spanish | LILACS, CUMED | ID: biblio-1125127

ABSTRACT

Se describen 2 casos clínicos de adolescentes de ambos sexos, quienes presentaron edemas en el lado izquierdo de la mandíbula con reabsorción dental y en la porción anterior del maxilar, respectivamente. La histopatología reveló una variante folicular intraósea del tumor odontogénico adenomatoide. El tratamiento quirúrgico empleado fue una enucleación con resultados satisfactorios.


Two cases reports of adolescents from both sexes are described, they presented edemas in the left side of the maxillary with dental reabsorption and in the anterior portion of the maxillary, respectively. The histopathology revealed an intraosseous folicular variety of the adenomatoid odontogenic tumor. The surgical treatment used was an enucleation with satisfactory results.


Subject(s)
Odontogenic Tumors/surgery , Edema , Odontogenic Tumors/diagnosis , Odontogenic Tumors/diagnostic imaging , Adolescent
13.
Rev. cient. odontol ; 8(1): e008, ene.-abr. 2020.
Article in Spanish | LIPECS, LILACS, LIPECS | ID: biblio-1095501

ABSTRACT

Los restos epiteliales de Malassez son células que se encuentran alrededor de las raíces de las piezas dentarias y forman parte de los tejidos del ligamento periodontal, donde se disponen en forma de red. Las funciones que desempeñan no son muy específicas; sin embargo, se demostró su participación en el mantenimiento del espacio del ligamento periodontal, la regeneración del tejido periodontal, la regeneración del cemento, entre otros. Además, tienen capacidad de diferenciarse en otros linajes celulares, lo que demuestra su capacidad como células madres, y el papel más conocido que tienen es su participación y proliferación en la formación de diversas patologías, como quistes y tumores odontogénicos. (AU)


Epithelial rests of Malassez are cells that are arranged in a network located around the roots of the teeth forming part of the periodontal ligament tissues. The functions that these cells perform are not very specific, however, they have shown to participate in the maintenance of the periodontal ligament space, regeneration of periodontal tissue, including cement regeneration among others. In addition, they are able to differentiate into other cell lineages, thereby demonstrating their capacity as stem cells. These cells are best known for their role in the participation and proliferation of the formation of different pathologies, such as cysts and odontogenic tumors. (AU)


Subject(s)
Humans , Periodontal Ligament , Stem Cells , Odontogenic Cysts , Odontogenic Tumors , Malassezia
14.
Autops. Case Rep ; 10(1): 2019127, Jan.-Mar. 2020. ilus
Article in English | LILACS | ID: biblio-1087659

ABSTRACT

Peripheral Ameloblastoma (PA) is a benign odontogenic tumor, arising from the cell rest of Serres, reduced enamel epithelium and basal cells of the surface epithelium. Peripheral ameloblastoma is a rare odontogenic neoplasm occurring commonly in the mandibular gingiva. PA clinically resembles other peripherally occurring lesions like pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and squamous papilloma. The recurrence rate of PA is 16-19% which demands a straight follow up. We report a case of recurrent peripheral ameloblastoma occurring in a 72-year old male located in the mandibular lingual gingiva in relation to the 44, 45 element's regions. The patient had a primary lesion excised from the same site 6 years before which was diagnosed as ameloblastoma.


Subject(s)
Humans , Female , Aged , Ameloblastoma/diagnosis , Jaw Neoplasms , Odontogenic Tumors , Neoplasm Recurrence, Local
15.
Article in English | WPRIM | ID: wpr-876458

ABSTRACT

@#A 37-year-old woman consulted for a slow-growing mass of one-year duration on the left side of the mandible with associated tooth mobility. Clinical examination showed buccal expansion along the left hemi-mandible from the mid-body to the molar-ramus region with associated mobility and displacement of the pre-molar and molar teeth. Radiographs showed a well-defined unilocular radiolucency with root resorption of the overlying teeth. Decompression and unroofing of the cystic lesion was performed. Received in the surgical pathology laboratory were several gray-white rubbery to focally gritty tissue fragments with an aggregate diameter of 1 cm. Histopathologic examination shows a fibrocollagenous cyst wall lined by a fairly thin and flat stratified squamous epithelium without rete ridges. (Figure 1) The epithelium is parakeratinized with a wavy, corrugated surface while the basal layer is cuboidal and quite distinct with hyperchromatic nuclei. (Figure 2) Based on these features, we signed the case out as odontogenic keratocyst (OKC). Odontogenic keratocysts are the third most common cysts of the gnathic bones, comprising up to 11% of all odontogenic cysts, and most frequently occurring in the second to third decades of life.1,2 The vast majority of cases occur in the mandible particularly in the posterior segments of the body and the ramus. They typically present as fairly large unilocular radiolucencies with displacement of adjacent or overlying teeth.1 If associated with an impacted tooth the radiograph may mimic that of a dentigerous cyst.2 Microscopically, the parakeratinized epithelium without rete ridges, and with a corrugated luminal surface and a prominent cuboidal basal layer are distinctive features that enable recognition and diagnosis.1,2,3 Occasionally, smaller “satellite” or “daughter” cysts may be seen within the underlying supporting stroma, sometimes budding off from the basal layer. Most are unilocular although multilocular examples are encountered occasionally.1 Secondary inflammation may render these diagnostic features unrecognizable and non-specific.2 Morphologic differential diagnoses include other odontogenic cysts and unicystic ameloblastoma. The corrugated and parakeratinized epithelial surface is sufficiently consistent to allow recognition of an OKC over other odontogenic cysts, while the absence of a stellate reticulum and reverse nuclear polarization will not favor the latter diagnosis.2,3 Odontogenic keratocysts are developmental in origin arising from remnants of the dental lamina. Mutations in the PTCH1 gene have been identified in cases associated with the naevoid basal cell carcinoma syndrome as well as in non-syndromic or sporadic cases.1,3 These genetic alterations were once the basis for proposing a neoplastic nature for OKCs and thus the nomenclature “keratocystic odontogenic tumor” was for a time adopted as the preferred name for the lesion.3,4 Presently, it is felt there is not yet enough evidence to support a neoplastic origin and hence the latest WHO classification reverts back to OKC as the appropriate term.1 Sekhar et al. gives a good review of the evolution of the nomenclature for this lesion.3 Treatments range from conservative enucleation to surgical resection via peripheral osteotomy.5 Reported recurrences vary in the literature ranging from less than 2% of resected cases up to 28% for conservatively managed cases.1,5 These are either ascribed to incomplete removal or to the previously mentioned satellite cysts - the latter being a feature associated with OKCs that are in the setting of the naevoid basal cell carcinoma syndrome.1,2,3 Thus, long term follow-up is recommended.5 Malignant transformation, though reported, is distinctly rare.


Subject(s)
Odontogenic Cysts , Odontogenic Tumors , Basal Cell Nevus Syndrome
16.
Article in English | WPRIM | ID: wpr-876446

ABSTRACT

@#Objective: To report the case of a rare benign odontogenic tumor in an adolescent girl which was successfully managed by complete excision and curettage of underlying bone. Methods: Design: Case Report Setting: Tertiary National University Hospital Patient: One Result: A 15-year-old girl with a 3-year history of a large Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor) atypically occurring in the posterior maxillary alveolar ridge and compressing the maxillary antrum underwent tumor excision via gingivobuccal approach and curettage of the emaining mucosa in the cavity in consideration of her patient’s aesthetic concerns. No recurrence has been observed two years post-op and she remains asymptomatic on regular follow-up. Conclusion: A calcifying epithelial odontogenic tumor can be managed conservatively with close follow-up to monitor recurrence.


Subject(s)
Humans , Adolescent , Odontogenic Tumors , Skin Neoplasms
17.
J. appl. oral sci ; 28: e20190067, 2020. tab
Article in English | LILACS, BBO | ID: biblio-1056597

ABSTRACT

Abstract Objectives: This study approaches the history of reclassifications and redefinitions around the odontogenic keratocyst (OK), as proposed by the World Health Organization (WHO), and aims to understand the impact of those changes on the prevalence and epidemiology of odontogenic tumors (OTs). Methodology: Cases of OTs diagnosed in an Oral Pathology service between January 1996 and December 2016 were reviewed. Demographic data of patients such as age, gender and site of lesions were retrieved from their respective records. Results: Within the studied period, 7,805 microscopic reports were elaborated and 200 (2.56%) of these were diagnosed as OTs. Out of these 200, between 1996 and 2005, prior to the 2005 WHO classification, there were 41 (20.5%) OTs cases, being odontoma the most frequent (23; 56.09%), followed by ameloblastoma (8; 19.51%) and myxoma (03; 7.31%). Between 2006 and 2016, after the previous 2005 WHO classification there were 159 (79.5%) OTs, being odontogenic keratocystic tumor (KCOT) the most frequent (68; 42.76%), followed by odontoma (39; 24.52%) and ameloblastoma (21; 13.20%). Conclusions: As of today, the most recent WHO classification to be followed brings KCOT back to the cyst category, which will impact on the prevalence and epidemiology of OTs; thus, this study was able to identify a considerable increase (287.80%) in the prevalence of OTs when the 2005 WHO classification was utilized. Despite being an important academic exercise, classifying odontogenic lesions and determining whether to place the odontogenic keratocyst in a cyst or tumor category is crucial to establish the correct diagnosis and treatment to follow, whether by oral medicine or oral surgery specialist, or by the general practitioner.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , World Health Organization , Odontogenic Tumors/classification , Brazil/epidemiology , Odontogenic Tumors/diagnosis , Odontogenic Tumors/epidemiology , Prevalence
18.
Braz. dent. sci ; 23(1): 1-5, 2020. ilus
Article in English | LILACS, BBO | ID: biblio-1050102

ABSTRACT

Ameloblastoma is an odontogenic tumor that affects the bones of the jaw, often affecting posterior region of the mandible. It is a benign neoplasm and is frequently associated to an unerupted tooth. The purpose of this article is to report a case of failure in making an immediate full denture in a patient that had an ameloblastoma. A female patient aged 67 years complained of a hard swelling in the right mandible at the premolar region, that she noted after teeth extraction and confection of an immediate denture. Intraoral examination showed buccal and lingual cortical plate expansion and radiograph examination showed multilocular radiolucency with a well-defined margin. Aspiration was nonproductive and the provisional diagnosis was ameloblastoma. An incisional biopsy was performed and the histopathological report was conclusive of an acanthomatous ameloblastoma. The patient was sent for surgical excision of the lesion and after three years, the patient returned reporting that she was operated elsewhere in the past year and had an unsuccessful bone graft. She was sent to a prosthodontist to make a complete denture. In the present case the ameloblastoma was diagnosed only after the teeth extraction and immediate denture (AU)


O ameloblastoma é um tumor odontogênico que afeta os ossos maxilares, geralmente a região posterior de mandíbula. É uma neoplasia benigna frequentemente associada a um dente não irrompido. O objetivo deste artigo é relatar um caso de prótese total imediata confeccionada para uma paciente com ameloblastoma na região anterior da mandíbula. Paciente do sexo feminino, 67 anos, queixou-se de aumento de volume na região de pré-molares inferiores do lado direito após extração dentária e confecção de prótese total imediata. Ao exame clínico intrabucal foi observada expansão da cortical vestibular e lingual e o exame radiográfico revelou radiolucência multilocular com margem bem definida. A punção aspirativa não foi produtiva e o diagnóstico provisório foi de ameloblastoma. Foi realizada biópsia incisional e o laudo histopatológico foi conclusivo para ameloblastoma acantomatoso. A paciente foi encaminhada para ressecção cirúrgica da lesão e não retornou. Depois de três anos procurou atendimento e relatou que tinha sido submetida a cirurgia com colocação de enxerto ósseo para implante sem sucesso. O enxerto ósseo foi perdido e a paciente necessitava de nova prótese total. Ela foi encaminhada a um protesista. No presente caso, o diagnóstico de ameloblastoma foi feito somente após a instalação da prótese total imediata, quando a paciente notou aumento de volume (AU).


Subject(s)
Humans , Female , Aged , Ameloblastoma , Mandibular Neoplasms , Odontogenic Tumors , Diagnosis
19.
Article in Spanish | LILACS | ID: biblio-1058329

ABSTRACT

RESUMEN: El fibroma odontogénico central (FOC) es una neoplasia benigna poco frecuente que representa alrededor del 1.5% de los tumores odontogénicos intraóseos. Su presentación es exclusiva de huesos maxilares. Tiene origen mesodérmico, pudiendo derivar del folículo dentario, ligamento periodontal y/o la papila dental. Tradicionalmente presenta dos variantes histológicas: un tipo que es pobre en epitelio y otro tipo que es rico en epitelio con focos de material calcificado. En la mayoría de los casos muestra un crecimiento lento y progresivo que produce expansión cortical con o sin sintomatología. Radiográficamente es común observar una imagen radiolúcida y unilocular, raramente se pueden exhibir lesiones multiloculares y/o de radiolucidez mixta. El tratamiento indicado en la mayoría de los casos es la enucleación del tumor. El siguiente reporte de caso describe las características clínicas, imageneológicas e histopatológicas de una lesión mandibular con diagnóstico de FOC y cuyo tratamiento realizado fue la enucleación del tumor.


ABSTRACT: Central odontogenic fibroma (COF) is a rare benign neoplasm that accounts for about 1.5% of intraosseous odontogenic tumors. Its presentation is exclusively in the maxillary bones. It has a mesodermal origin, being able to derive from the dental follicle, periodontal ligament and/or the dental papilla. Traditionally, it has two histological variants: one type that is poor in epithelium and another type that is rich in epithelium with foci of calcified material. In most cases it shows a slow and progressive growth that produces cortical expansion with or without symptomatology. Radiographically, it is common to observe a radiolucent and unilocular image, but rarely multilocular lesions and / or mixed radiolucency can be exhibited. The treatment indicated in most cases is the enucleation of the tumor. The following case report describes the clinical, imaging and histopathological characteristics of a mandibular lesion diagnosed with FOC and whose treatment was enucleation of the tumor.


Subject(s)
Humans , Female , Adult , Odontogenic Tumors , Fibroma , Mandible , Maxilla , Neoplasms
20.
Rev. Ateneo Argent. Odontol ; 61(2): 8-12, nov. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1095111

ABSTRACT

El ameloblastoma es un tumor benigno derivado del epitelio odontogénico, clasificado actualmente de acuerdo al CIE 10-EO/SNOMED en el capítulo de tumores (neoplasia) benigna como D16.5/M-93100. Presenta un patrón de crecimiento lento, localmente agresivo, pudiendo causar, o no, grandes deformaciones faciales, en mandíbula o maxilar superior. De localización preferencial mandibular, el 75%, en el área molar y rama ascendente; mientras que, en maxilar superior, se concentran en el área molar con posible compromiso de seno maxilar y suelo de fosas nasales. La edad de presentación más frecuente es entre 20-40 años, siendo rara en pacientes pediátricos. En el tratamiento del mismo se valora tipo clínico, localización y tamaño del tumor, y la edad del paciente. El presente caso clínico destaca la importancia del oportuno diagnóstico clínico-patológico, su clasificación y el uso de nuevas técnicas complementarias (AU)


Ameloblastoma is a benign tumor derived from the Odontogenic epithelium, currently classified according to ICD 10-EO / SNOMED in the Chapter of Benign Tumors (Neoplasia) as D16.5 / M-93100. It has a slow growth pattern, locally aggressive, may or may not cause large facial deformations, in the jaw or upper jaw. Preferential mandibular location, 75% in the molar area and ascending limb; while in the upper jaw they are concentrated in the molar area with possible involvement of the maxillary sinus and the floor of the nostrils. The most frequent age of presentation is between 20-40 years, being rare in pediatric patients. In the treatment of the same, clinical type, location and size of the tumor, as the age of the patient, is assessed. The present clinical case highlights the importance of the appropriate clinical-pathological diagnosis, its classification and the use of new complementary techniques (AU)


Subject(s)
Humans , Male , Adolescent , Ameloblastoma/surgery , Ameloblastoma/diagnostic imaging , Odontogenic Tumors , Oral Surgical Procedures , World Health Organization , Radiography, Panoramic , International Classification of Diseases , Histological Techniques , Reconstructive Surgical Procedures , Dental Service, Hospital
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