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1.
Nursing (Säo Paulo) ; 24(281): 6347-6354, out.-2021.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1344576

ABSTRACT

Objetivo: Construir e obter a evidência de validade de conteúdo da Escala de Avaliação do Odor de Feridas Neoplásicas. Método: Estudo conduzido em 2019 em duas etapas: construção da escala a partir de revisão de literatura e validação a partir da avaliação de 17 juízes que responderam a um questionário por meio de ferramenta online. Foi aplicado o cálculo de índice de Validade de Conteúdo (IVC) para a análise dos dados. Resultados: As principais mudanças indicadas foram: retirada do swab para avaliar a carga microbiana e a inclusão do exsudato sanguinolento como item relevante na avaliação do odor. O IVC da escala foi de 0,91, indicando que 91% dos juízes consideraram a escala um instrumento relevante para avaliar o odor das feridas neoplásicas. Conclusão: A escala desenvolvida foi aprovada como instrumento de análise clínica que poderá auxiliar os profissionais na avaliação mais consistente do odor das feridas neoplásicas.(AU)


Objective: To build and obtain evidence of content validity of the Neoplastic Wound Odor Rating Scale. Materials and method: Two-step study: construction of the scale based on a literature review and validation based on the evaluation of 17 judges who answered a questionnaire through an online tool. The Content Validity Index (CVI) calculation was applied for data analysis. Results: The main changes indicated were: removal of the swab to assess the microbial load and the inclusion of bloody exudate as a relevant item in the odor assessment. The scale's CVI was 0.91, indicating that 91% of the judges considered the scale a relevant instrument to assess the odor of neoplastic wounds. Conclusion: The developed scale was approved as a clinical analysis instrument that can help professionals to more consistently assess the odor of neoplastic wounds.(AU)


Objetivo: Construir y obtener evidencia de la validez de contenido de la Escala de calificación de olores de heridas neoplásicas. Materiales y método: Estudio de dos pasos: construcción de la escala a partir de una revisión de la literatura y validación a partir de la evaluación de 17 jueces que respondieron un cuestionario a través de una herramienta online. Se aplicó el cálculo del Índice de Validez de Contenido (IVC) para el análisis de datos. Resultados: Los principales cambios indicados fueron: extracción del hisopo para evaluar la carga microbiana y la inclusión de exudado sanguinolento como elemento relevante en la evaluación de olores. El CVI de la escala fue de 0,91, lo que indica que el 91% de los jueces consideró la escala un instrumento relevante para evaluar el olor de las heridas neoplásicas. Conclusión: La escala desarrollada fue aprobada como un instrumento de análisis clínico que puede ayudar a los profesionales a evaluar de manera más consistente el olor de las heridas neoplásicas.(AU)


Subject(s)
Humans , Skin Neoplasms , Wounds and Injuries/microbiology , Odorants/analysis
2.
São Paulo; s.n; 2021. 109 p.
Thesis in Portuguese | LILACS | ID: biblio-1362004

ABSTRACT

A tecnologia de nanobolhas é capaz de transformar uma simples gota em milhões de pequenas bolhas, com isso, aumentando a superfície de contato e resultando na destruição de contaminantes por meio de uma rápida reação química. O sistema de nanobolhas, quando aplicado, tem grande poder de penetração, agindo rapidamente sobre a contaminação de solos ou da água graças ao seu minúsculo tamanho e à sua enorme superfície de contato. O objetivo geral do presente trabalho foi o de estudar e analisar a redução do odor após a aplicação da tecnologia das nanobolhas em um canal do rio Pinheiros. Dentre os objetivos específicos, destacaram-se a análise da eficiência do sistema de NB na remoção de odor e os benefícios secundários da aplicação dessa tecnologia e seu potencial tecnológico. A iniciativa de estudar o processo de nanobolhas é atribuída, principalmente, a importantes peculiaridades nas suas propriedades físicas, químicas e físico-químicas, bem como ao potencial tecnológico de utilização nas mais distintas áreas, entre as quais se incluem a flotação avançada de poluentes aquosos e aplicações na medicina, na limpeza de superfícies, na indústria da mineração, em sistemas de geração de energia, na agricultura, na aceleração do metabolismo em espécies animais e vegetais, entre outras práticas. Os métodos de geração, caracterização e aplicações das nanobolhas se constituem em áreas de pesquisas emergentes e em acelerado crescimento, especialmente nas últimas duas décadas. Os resultados obtidos com esta linha de pesquisa contribuirão para estudos que busquem uma tecnologia adicional às já estudadas e testadas para a limpeza do rio Pinheiros, pois a utilização dessa tecnologia, nos testes realizados no canal do rio Pinheiros, mostrou resultados bastante promissores, apresentando facilidades operacionais e controle dos parâmetros que influenciam na geração de gases odoríferos com baixo custo, quando comparado com o das tecnologias convencionais utilizando apenas energia, e não produtos químicos e sem geração de lodo. Mediante a aplicação da tecnologia de nanobolhas em águas poluídas, foi analisado o potencial dessas bolhas para reduzir odores, assim como a viabilização de uma diferente rota de tratamento de águas superficiais poluídas para sistemas com altas vazões, velocidades e altas concentrações de sólidos.


Nanobubbles (NB) technology can transform a single drop into millions of small bubbles, increasing the contact surface and resulting in the destruction of contaminants through a fast-chemical reaction. Due to nanobubbles tiny size, the nanobubble system has a great penetrating power and its huge contact surface acts quickly on soil or water contamination. The general objective of the present work will be to study and to analyze the smell reduction after the application of nanobubble technology in a channel of the Pinheiro River. Among the specific objectives, we would like to highlight the NB system efficiency analysis related to smell removal, as well as the secondary benefits of applying this technology and its technological potential. The initiative to study the nanobubble process is mainly attributed to important peculiarities in its physical, chemical and physicochemical properties, as well as related to the technological potential of its use in different areas, including aqueous pollutants advanced flotation, applications in medicine, surface cleaning, in the mining industry, in energy generation systems, in agriculture, in the acceleration of metabolism in animal and plant species, among others. The methods of generation, characterization, and application of nanobubbles have emerged and is growing rapidly in the research areas, mainly in the last two decades. The results obtained with this study will contribute with researchers that seek additional technologies, among those already been studied, to be tested for cleaning the Pinheiros River. The use of this technology has already been tested in the Pinheiros River Channel, showing very promising results, presenting operational facilities and control of parameters that influence the generation of odoriferous gases with low cost when compared to conventional technologies based only on energy, without the use of chemicals and without generating sludge. Through the application of nanobubble technology in polluted water, the potential of these bubbles to reduce smell will be analyzed to enable a different route of polluted surface water treatment for systems with high flow rates and high concentrations of solids.


Subject(s)
Surface Waters , Water Purification , Odorants/prevention & control , Environment and Public Health
3.
Article in Chinese | WPRIM | ID: wpr-921706

ABSTRACT

This study adopted headspace-gas chromatography-mass spectrometry(HS-GC-MS) and electronic nose to detect volatile components from Myristicae Semen samples with varying degrees of mildew, aiming at rapidly identifying odor changes and substance basis of Myristicae Semen mildew. The experimental data were analyzed by electronic nose and principal component analysis(PCA). The results showed that Myristicae Semen samples were divided into the following three categories by electronic nose and PCA: mildew-free samples, slightly mildewy samples, and mildewy samples. Myristicae Semen samples with different degrees of mildew greatly varied in volatile components. The volatile components in the samples were qualitatively and quantitatively detected by HS-GC-MS, and 59 compounds were obtained. There were significant differences in the composition and content in Myristicae Semen samples with different degrees of mildew. The PCA results were the same as those by electronic nose. Among them, 3-crene, D-limonene, and other terpenes were important indicators for the identification of mildew. Bicyclo[3.1.0]hexane, 4-methylene-1-(1-methylethyl)-, terpinen-4-ol, and other alcohols were key substances to distinguish the degree of mildew. In the later stage of mildew, Myristicae Semen produced a small amount of hydroxyl and aldehyde compounds such as acetaldehyde, 2-methyl-propionaldehyde, 2-methyl-butyraldehyde, and formic acid, which were deduced as the material basis of the mildew. The results are expected to provide a basis for the rapid identification of Myristicae Semen with different degrees of mildew, odor changes, and the substance basis of mildew.


Subject(s)
Electronic Nose , Gas Chromatography-Mass Spectrometry , Odorants/analysis , Semen/chemistry , Solid Phase Microextraction , Volatile Organic Compounds/analysis
4.
Chinese Journal of Biotechnology ; (12): 1998-2009, 2021.
Article in Chinese | WPRIM | ID: wpr-887777

ABSTRACT

Aromatic compounds make up a large part of fragrances and are traditionally produced by chemical synthesis and direct extraction from plants. Chemical synthesis depends on petroleum resources and has disadvantages such as causing environment pollutions and harsh reaction conditions. Due to the low content of aromatic compounds in plants and the low yield of direct extraction, plant extractions require large amounts of plant resources that occupy arable land. In recent years, with the development of metabolic engineering and synthetic biology, microbial synthesis of aromatic compounds from renewable resources has become a promising alternative approach to traditional methods. This review describes the research progress on the synthesis of aromatic fragrances by model microorganisms such as Escherichia coli or yeast, including the synthesis of vanillin through shikimic acid pathway and the synthesis of raspberry ketone through polyketide pathway. Moreover, this review highlights the elucidation of native biosynthesis pathways, the construction of synthetic pathways and metabolic regulation for the production of aromatic fragrances by microbial fermentation.


Subject(s)
Biosynthetic Pathways , Metabolic Engineering , Odorants , Shikimic Acid , Synthetic Biology
5.
Electron. j. biotechnol ; 46: 1-7, jul. 2020. ilus, graf, tab
Article in English | LILACS | ID: biblio-1223252

ABSTRACT

BACKGROUND: Fragrance is one of the most important quality traits in rice, and the phenotype is attributed to the loss-of-function betaine aldehyde dehydrogenase (BADH2) gene. At least 12 allelic variations of BADH2 have been identified, and some of these have been applied to rice fragrance breeding using traditional molecular markers and Sanger sequencing techniques. However, these traditional methods have several limitations, such as being very expensive, imprecise, inefficient, and having security issues. Thus, a new molecular marker technology must be developed to improve rice fragrance breeding. RESULTS: In this study, more than 95% of the cultivated fragrant rice varieties belonged to a 7-bp deletion in exon 2 (badh2-E2) or an 8-bp deletion and 3-bp variation in exon 7 (badh2-E7). Both allelic variations resulted in the loss of function of the badh2 gene. We developed two novel SNP molecular markers, SNP_badh2-E2 and SNP_badh2- E7, related to the alleles. Their genotype and phenotype were highly cosegregated in the natural variation of rice accessions, with 160 of the 164 fragrant rice varieties detected with the two markers. These markers cosegregated with the fragrance phenotype in the F2 population. CONCLUSIONS: Two functional SNP molecular markers of badh2-E2 and badh2-E7 allelic variations were developed. These functional SNP molecular markers can be used for genotype and genetic improvement of rice fragrance through marker-assisted selection and will significantly improve the efficiency of fragrant rice breeding and promote commercial molecular breeding of rice in the future.


Subject(s)
Oryza/enzymology , Oryza/genetics , Betaine-Aldehyde Dehydrogenase/metabolism , Genetic Markers , Alleles , Genotyping Techniques/methods , Genotype , Odorants
6.
Rev. Assoc. Med. Bras. (1992) ; 66(1): 18-24, Jan. 2020. tab, graf
Article in English | LILACS | ID: biblio-1091897

ABSTRACT

SUMMARY OBJECTIVE To compare two combinations of olfactory agents for olfactory training therapy of olfactory dysfunction after upper respiratory tract infection (URTI) and investigate the influencing factors on clinical effects. METHODS 125 patients with olfactory dysfunction were randomly divided into two groups: test and control. During the olfactory training, four odors were used in both groups. The olfactory training lasted for 24 weeks. Then, participants were tested using Sniffin' Sticks and threshold-discrimination-identification (TDI) composite scoring before treatment and at 1, 3, and 6 months after treatment. The TDI scores were compared at different time points between the groups and within them, and influence factors were analyzed. RESULTS There was no significant difference in TDI scores between both groups. Furthermore, TDI scores did not significantly change after one month of treatment in either of the groups. After 3 and 6 months of treatment, TDI scores both significantly increased, and the odor discrimination and identification abilities significantly strengthened in both groups; however, the odor thresholds did not improve. The course of the disease was a significant influencing factor on the therapeutic effect of olfactory training for both groups. CONCLUSION The combination of essential balm, vinegar, alcohol, and rose perfume for olfactory training, which are scents commonly found in daily life, can effectively cure URTI-induced olfactory dysfunction, and significantly improve the odor discrimination and identification abilities. Furthermore, prolonging the treatment time can help with the recovery of olfactory functions, and earlier olfactory training can improve the therapeutic effect.


RESUMO OBJETIVO Comparar duas combinações de agentes olfativos para uso em terapia de treinamento olfativo no tratamento de disfunção olfatória após infecção do trato respiratório superior (ITRS) e investigar os fatores que influenciam os efeitos clínicos. METODOLOGIA 125 pacientes com disfunção olfativa foram divididos aleatoriamente em dois grupos: teste e controle. Durante o treinamento olfativo, quatro odores foram utilizados em ambos os grupos. O treinamento olfativo durou 24 semanas. Em seguida, os participantes foram testados usando Sniffin' Sticks e o escore de discriminação, limiar e identificação (TDI) antes do tratamento e 1, 3 e 6 meses após o ele. Os escores de TDI foram comparados em momentos diferentes, entre os grupos e dentro deles, e os fatores de influência foram analisados. RESULTADOS Não houve diferença significativa nos escores de TDI entre os dois grupos. Além disso, os escores de TDI não demonstração nenhuma alteração significa após um mês de tratamento em ambos os grupos. Após 3 e 6 meses de tratamento, ambos os escores de TDI aumentaram significativamente, e as habilidades de identificação e discriminação de odores melhoraram significativamente em ambos os grupos; contudo, os limiares de odor não demonstraram melhora. O curso da doença foi um importante fator de influência no efeito terapêutico do treinamento olfativo em ambos os grupos. CONCLUSÃO A combinação de bálsamo essencial, vinagre, álcool, e perfume de rosas no treinamento olfativo, todos aromas comumente encontrados na vida cotidiana, podem efetivamente curar disfunção olfativa induzida por ITRS e melhorar significativamente as habilidades de discriminação e identificação de odores. Além disso, a prolongamento do tempo de tratamento pode ajudar na recuperação das funções olfativas, e o início antecipado do treinamento olfativo pode melhorar o efeito terapêutico.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Respiratory Tract Infections/complications , Olfaction Disorders/etiology , Olfaction Disorders/therapy , Odorants , Reference Values , Sensory Thresholds , Time Factors , Logistic Models , Prospective Studies , Regression Analysis , Treatment Outcome , Recovery of Function/physiology , Olfactometry , Middle Aged
7.
Rev. latinoam. enferm. (Online) ; 28: e3248, 2020. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1058533

ABSTRACT

Objective: to compare the effect of exposure to unpleasant odors in a simulated clinical environment on the emotions of undergraduate nursing students. Method: quasi-experimental study. A total of 24 nursing students participated the study, divided into two groups, 12 in the intervention group with exposure to unpleasant odors, and 12 in the control group without exposure to unpleasant odors. To simulate the unpleasant vomiting odor in intervention group, fermented foods were used: boiled oats, curdled milk, spoiled Parmesan cheese, raw egg, pea soup, raisins and vinegar. Participants were filmed and the facial expression analysis was performed at six critical points: student approach; report of the complaint; clinical evaluation; and patient occurrence, intervention and reevaluation based on what was proposed by the Circumplex model of emotions recognition. Results: a total of 83,215 emotions related to the six critical points were verified. At the critical point of the proposed scenario with exposure to unpleasant odors, the intervention group presented the basic emotion of sadness and the Control Group, anger. Conclusion: it is inferred that the inclusion of unpleasant odors in the simulated scenarios can broaden the emotional development of health students.


Objetivo: comparar o efeito da exposição aos odores desagradáveis em ambiente clínico simulado nas emoções de estudantes de graduação de enfermagem. Método: estudo quase experimental. Participaram 24 estudantes de enfermagem, alocados em dois grupos, 12 no Grupo Intervenção com exposição aos odores desagradáveis e 12 no Grupo Controle sem exposição aos odores desagradáveis. Para simulação do odor desagradável de vômito, no Grupo Intervenção, foram utilizados alimentos fermentados: aveia cozida, leite coalhado, queijo parmesão estragado, ovo cru, sopa ervilha, uvas-passas e vinagre. Os participantes foram filmados e a análise das expressões faciais foi realizada em seis pontos críticos: abordagem pelo estudante; relato da queixa; avaliação clínica; e intercorrência, intervenção e reavaliação do paciente a partir do proposto pelo modelo Circumplex de reconhecimento de emoções. Resultados: verificou-se 83.215 emoções relacionadas aos seis pontos críticos. No ponto crítico do cenário proposto com exposição aos odores desagradáveis o grupo intervenção apresentou a emoção básica de tristeza e o grupo controle, raiva. Conclusão: infere-se que a inclusão de odores desagradáveis nos cenários simulados pode ampliar o desenvolvimento emocional de estudantes da área da saúde.


Objetivo: comparar el efecto de la exposición a los olores desagradables en ambiente clínico simulado en las emociones de estudiantes de grado de enfermería. Método: estudio cuasiexperimental. Participaron 24 estudiantes de enfermería, distribuidos en dos grupos, 12 en el Grupo Intervención con exposición a los olores desagradables y 12 en el Grupo Control sin exposición a los olores desagradables. Para simular el olor desagradable de vómito, en el grupo intervención, se utilizaron alimentos fermentados: avena cocida, leche cuajada, queso parmesano estropeado, huevo crudo, sopa de arvejas, uvas pasas y vinagre. Los participantes fueron filmados y las expresiones faciales se analizaron en relación con seis puntos críticos: abordaje por el estudiante; relato de la queja; evaluación clínica; e intercurrencia, intervención y reevaluación del paciente con base en lo propuesto por el modelo Circumplex de reconocimiento de emociones. Resultados: se verificaron 83.215 emociones relacionadas con los seis pontos críticos. En el punto crítico del escenario propuesto con exposición a los olores desagradables, el grupo intervención presentó la emoción básica tristeza; y el grupo control, rabia. Conclusión: se deduce que la inclusión de olores desagradables en los escenarios simulados puede ampliar el desarrollo emocional de estudiantes del área de la salud.


Subject(s)
Humans , Male , Female , Students, Nursing , Emotions/physiology , Facial Expression , Simulation Training , Odorants
8.
Rev. latinoam. enferm. (Online) ; 28: e3248, 2020. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1094027

ABSTRACT

Objective: to compare the effect of exposure to unpleasant odors in a simulated clinical environment on the emotions of undergraduate nursing students. Method: quasi-experimental study. A total of 24 nursing students participated the study, divided into two groups, 12 in the intervention group with exposure to unpleasant odors, and 12 in the control group without exposure to unpleasant odors. To simulate the unpleasant vomiting odor in intervention group, fermented foods were used: boiled oats, curdled milk, spoiled Parmesan cheese, raw egg, pea soup, raisins and vinegar. Participants were filmed and the facial expression analysis was performed at six critical points: student approach; report of the complaint; clinical evaluation; and patient occurrence, intervention and reevaluation based on what was proposed by the Circumplex model of emotions recognition. Results: a total of 83,215 emotions related to the six critical points were verified. At the critical point of the proposed scenario with exposure to unpleasant odors, the intervention group presented the basic emotion of sadness and the Control Group, anger. Conclusion: it is inferred that the inclusion of unpleasant odors in the simulated scenarios can broaden the emotional development of health students.


Objetivo: comparar o efeito da exposição aos odores desagradáveis em ambiente clínico simulado nas emoções de estudantes de graduação de enfermagem. Método: estudo quase experimental. Participaram 24 estudantes de enfermagem, alocados em dois grupos, 12 no Grupo Intervenção com exposição aos odores desagradáveis e 12 no Grupo Controle sem exposição aos odores desagradáveis. Para simulação do odor desagradável de vômito, no Grupo Intervenção, foram utilizados alimentos fermentados: aveia cozida, leite coalhado, queijo parmesão estragado, ovo cru, sopa ervilha, uvas-passas e vinagre. Os participantes foram filmados e a análise das expressões faciais foi realizada em seis pontos críticos: abordagem pelo estudante; relato da queixa; avaliação clínica; e intercorrência, intervenção e reavaliação do paciente a partir do proposto pelo modelo Circumplex de reconhecimento de emoções. Resultados: verificou-se 83.215 emoções relacionadas aos seis pontos críticos. No ponto crítico do cenário proposto com exposição aos odores desagradáveis o grupo intervenção apresentou a emoção básica de tristeza e o grupo controle, raiva. Conclusão: infere-se que a inclusão de odores desagradáveis nos cenários simulados pode ampliar o desenvolvimento emocional de estudantes da área da saúde.


Objetivo: comparar el efecto de la exposición a los olores desagradables en ambiente clínico simulado en las emociones de estudiantes de grado de enfermería. Método: estudio cuasiexperimental. Participaron 24 estudiantes de enfermería, distribuidos en dos grupos, 12 en el Grupo Intervención con exposición a los olores desagradables y 12 en el Grupo Control sin exposición a los olores desagradables. Para simular el olor desagradable de vómito, en el grupo intervención, se utilizaron alimentos fermentados: avena cocida, leche cuajada, queso parmesano estropeado, huevo crudo, sopa de arvejas, uvas pasas y vinagre. Los participantes fueron filmados y las expresiones faciales se analizaron en relación con seis puntos críticos: abordaje por el estudiante; relato de la queja; evaluación clínica; e intercurrencia, intervención y reevaluación del paciente con base en lo propuesto por el modelo Circumplex de reconocimiento de emociones. Resultados: se verificaron 83.215 emociones relacionadas con los seis pontos críticos. En el punto crítico del escenario propuesto con exposición a los olores desagradables, el grupo intervención presentó la emoción básica tristeza; y el grupo control, rabia. Conclusión: se deduce que la inclusión de olores desagradables en los escenarios simulados puede ampliar el desarrollo emocional de estudiantes del área de la salud.


Subject(s)
Humans , Male , Female , Students, Nursing/psychology , Emotions , Facial Expression , Simulation Training , Odorants
9.
Rev. latinoam. enferm. (Online) ; 28: e3248, 2020. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1101745

ABSTRACT

Objective: to compare the effect of exposure to unpleasant odors in a simulated clinical environment on the emotions of undergraduate nursing students. Method: quasi-experimental study. A total of 24 nursing students participated the study, divided into two groups, 12 in the intervention group with exposure to unpleasant odors, and 12 in the control group without exposure to unpleasant odors. To simulate the unpleasant vomiting odor in intervention group, fermented foods were used: boiled oats, curdled milk, spoiled Parmesan cheese, raw egg, pea soup, raisins and vinegar. Participants were filmed and the facial expression analysis was performed at six critical points: student approach; report of the complaint; clinical evaluation; and patient occurrence, intervention and reevaluation based on what was proposed by the Circumplex model of emotions recognition. Results: a total of 83,215 emotions related to the six critical points were verified. At the critical point of the proposed scenario with exposure to unpleasant odors, the intervention group presented the basic emotion of sadness and the Control Group, anger. Conclusion: it is inferred that the inclusion of unpleasant odors in the simulated scenarios can broaden the emotional development of health students.


Objetivo: comparar o efeito da exposição aos odores desagradáveis em ambiente clínico simulado nas emoções de estudantes de graduação de enfermagem. Método: estudo quase experimental. Participaram 24 estudantes de enfermagem, alocados em dois grupos, 12 no Grupo Intervenção com exposição aos odores desagradáveis e 12 no Grupo Controle sem exposição aos odores desagradáveis. Para simulação do odor desagradável de vômito, no Grupo Intervenção, foram utilizados alimentos fermentados: aveia cozida, leite coalhado, queijo parmesão estragado, ovo cru, sopa ervilha, uvas-passas e vinagre. Os participantes foram filmados e a análise das expressões faciais foi realizada em seis pontos críticos: abordagem pelo estudante; relato da queixa; avaliação clínica; e intercorrência, intervenção e reavaliação do paciente a partir do proposto pelo modelo Circumplex de reconhecimento de emoções. Resultados: verificou-se 83.215 emoções relacionadas aos seis pontos críticos. No ponto crítico do cenário proposto com exposição aos odores desagradáveis o grupo intervenção apresentou a emoção básica de tristeza e o grupo controle, raiva. Conclusão: infere-se que a inclusão de odores desagradáveis nos cenários simulados pode ampliar o desenvolvimento emocional de estudantes da área da saúde.


Objetivo: comparar el efecto de la exposición a los olores desagradables en ambiente clínico simulado en las emociones de estudiantes de grado de enfermería. Método: estudio cuasiexperimental. Participaron 24 estudiantes de enfermería, distribuidos en dos grupos, 12 en el Grupo Intervención con exposición a los olores desagradables y 12 en el Grupo Control sin exposición a los olores desagradables. Para simular el olor desagradable de vómito, en el grupo intervención, se utilizaron alimentos fermentados: avena cocida, leche cuajada, queso parmesano estropeado, huevo crudo, sopa de arvejas, uvas pasas y vinagre. Los participantes fueron filmados y las expresiones faciales se analizaron en relación con seis puntos críticos: abordaje por el estudiante; relato de la queja; evaluación clínica; e intercurrencia, intervención y reevaluación del paciente con base en lo propuesto por el modelo Circumplex de reconocimiento de emociones. Resultados: se verificaron 83.215 emociones relacionadas con los seis pontos críticos. En el punto crítico del escenario propuesto con exposición a los olores desagradables, el grupo intervención presentó la emoción básica tristeza; y el grupo control, rabia. Conclusión: se deduce que la inclusión de olores desagradables en los escenarios simulados puede ampliar el desarrollo emocional de estudiantes del área de la salud.


Subject(s)
Patient Simulation , Simulation Exercise , Education, Higher , Education, Nursing , Odorants
10.
Electron. j. biotechnol ; 38: 10-18, Mar. 2019. tab
Article in English | LILACS | ID: biblio-1051447

ABSTRACT

Malolactic fermentation (MLF) is a process in winemaking responsible for the conversion of L-malic acid to L-lactic acid and CO2, which reduces the total acidity, improves the biological stability, and modifies the aroma profile of wine. MLF takes place during or after alcoholic fermentation and is carried out by one or more species of lactic acid bacteria (LAB), which are either present in grapes and cellars or inoculated with malolactic starters during the winemaking process. Although the main bacterium among LAB used in commercial starter cultures for MLF has traditionally been Oenococcus oeni, in the last decade, Lactobacillus plantarum has also been reported as a malolactic starter, and many works have shown that this species can survive and even grow under harsh conditions of wine (i.e., high ethanol content and low pH values). Furthermore, it has been proved that some strains of L. plantarum are able to conduct MLF just as efficiently as O. oeni. In addition, L. plantarum exhibits a more diverse enzymatic profile than O. oeni, which could play an important role in the modification of the wine aroma profile. This enzymatic diversity allows obtaining several starter cultures composed of different L. plantarum biotypes, which could result in distinctive wines. In this context, this review focuses on showing the relevance of L. plantarum as a MLF starter culture in winemaking.


Subject(s)
Wine/microbiology , Lactobacillus plantarum/metabolism , Fermentation , Malates/metabolism , Vitis/microbiology , Odorants
11.
Cogit. Enferm. (Online) ; 24: e57906, 2019. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1019752

ABSTRACT

RESUMO Objetivo verificar os aspectos relacionados à prescrição, preparo e administração do metronidazol para controle do odor em feridas neoplásicas. Metodologia estudo transversal, com 80 profissionais de saúde de cinco hospitais referência em oncologia em Recife-PE, entre agosto e outubro de 2017. Foram analisadas as variáveis: caracterização profissional, critérios para prescrição, apresentação, diluição, aplicação, frequência e cuidados na aplicação. Calculou-se média e desvio padrão para as variáveis racionais discretas, e para categóricas dicotômicas, teste qui-quadrado com correção de Yates. Resultados os enfermeiros caracterizaram-se pelo pouco tempo de experiência (1-3 anos), menor frequência de especialização comparados aos médicos, porém maior frequência de atualização em cuidados paliativos. Quanto à prescrição e utilização do produto, observou-se prescrições alternativas e empíricas, com maceração de comprimidos 14 (53,8%) ou solução injetável em cinco (19,3%). Conclusão resultados evidenciam a escassa literatura sobre a temática e levantam a necessidade de construção de protocolos fundamentados em evidências científicas.


RESUMEN Objetivo verificar los aspectos asociados a la prescripción, preparación y administración del metronidazol para control del olor en heridas neoplásicas. Metodología estudio transversal, con 80 profesionales de salud de cinco hospitales referencia en oncología en Recife, PE, entre agosto y octubre de 2017. Se analizaron las variables: caracterización profesional, criterios para prescripción, presentación, dilución, aplicación, frecuencia y cuidados en la aplicación. Se calcularon el promedio y la desviación típica para las variables racionales discretas, y para categóricas dicotómicas, test chi cuadrado con corrección de Yates. Resultados los enfermeros se caracterizaron por el poco tiempo de experiencia (1-3 años), menor frecuencia de especialización en comparación con los médicos, pero con más frecuencia de actualización en cuidados paliativos. Acerca de la prescripción y uso del producto, se observaron prescripciones alternativas y empíricas, con maceración de pastillas 14 (53,8%) o solución inyectable en cinco (19,3%). Conclusión resultados evidencian la escasa literatura sobre la temática y apuntan a la necesidad de construcción de protocolos basados en evidencias científicas.


ABSTRACT Objective To check aspects related to the prescription, preparation and administration of metronidazole for the control of odor in neoplastic wounds. Methodology Cross-sectional study with 80 health professionals from five reference hospitals in oncology in Recife-PE, between August and October 2017. The following variables were analyzed: professional characterization, criteria for prescription, presentation, dilution, application, frequency and care in the application. Mean and standard deviation were calculated for obtaining the discrete rational variables, and chi-square test with Yates correction was used for dichotomous categorical variables. Results The nurses had little professional experience (1-3 years), less specialization compared to physicians, but had greater expertise in palliative care. Regarding the prescription and use of the product, 14 (53.8%) professionals used alternative and empirical prescriptions, with maceration of tablets, and five (19.3%) used injectable solution. Conclusion According to the results obtained, there are few studies on the subject and protocols based on scientific evidence should be constructed.


Subject(s)
Humans , Oncology Nursing , Wounds and Injuries , Metronidazole , Anti-Infective Agents , Odorants
12.
São Paulo; s.n; s.n; 2019. 50 p. ilus, graf, tab.
Thesis in Portuguese | LILACS | ID: biblio-1007412

ABSTRACT

O uso de óleos essenciais na indústria de fragrância tem crescido a cada ano. A indústria de cosméticos, em geral, tem buscado este tipo de ingrediente com o objetivo de agregar atributos únicos e melhores aos seus produtos e assim entregar, ao consumidor final, diferenciais que poderão valorizar suas formulações, além de simplesmente perfumar. O benefício de usar óleos naturais ou acordes de seus principais componentes em formulações de fragrâncias é que estes se tornam composições mais ricas, e em muitos casos, capazes de proporcionar perfumação prolongada ao produto, quando comparados àqueles sintetizados. A presença de compostos variados nos óleos, como terpenos e resinas, ajudam a promover singularidades à fragrância e até mesmo servem como inspiração às criações de produtos com descrições olfativas de produtos naturais. Croton tricolor (Euphorbiaceae), segundo avaliação inicial de um perfumista, apresentou excelentes características olfativas, o que facilitou seu uso nos estudos. A análise do óleo essencial de C. tricolor por cromatografia à gás com detector de ionização de chamas (CG/DIC) e cromatografia à gás acoplada à espectrometria de massas (CG/EM) permitiu quantificar e identificar seus principais marcadores, bem como utilizar estas informações para construção de acorde olfativo, reproduzindo o odor do produto natural. O óleo essencial de C. tricolor apresentou como principais componentes o biciclogermacreno (15,4%), espatulenol (10,5%) e o alfa-pineno (6,8%). A partir destes dados foi construído um acorde aromático que reproduziu o odor original, contendo alfa-pineno (7%), álcool fenetílico (5%), óleo de cedro (5%), óleo de laranja (0,5%), limoneno (1%), eucaliptol (0,5%) e nerolidol (0,3%). Os compostos majoritários, biciclogermacreno e espatulenol, não foram adicionados por não serem disponíveis comercialmente, por isso, usaram-se outras matérias-primas semelhantes em perfil olfativo e ofertadas no mercado, como foi o caso do uso de álcool fenetílico, óleo de cedro e óleo de laranja na criação do acorde. Os resultados evidenciaram que a criação de acordes é um método economicamente viável para a reprodução de odores naturais que podem ser utilizados em formulações de fragrâncias, além de ajudar a resolver problemas na produção e comercialização de óleos essenciais como, sazonalidade e reprodutibilidade


The use of essential oils in the fragrance industry has grown every year. The cosmetics industry has generally sought this type of ingredient, with the aim of providing its products with differentiated benefits (unique and better attributes), and thus delivering to the final consumer a differential that can enhance their formulations, besides simply perfuming their products (theirs). The benefit of using natural oils or accords of their major components in fragrance formulations makes them richer, and in many cases capable of providing prolonged perfuming to the final product when compared to synthesized products. The presence of varied compounds in the oils, such as terpenes or (and) resins, helps to promote differentiated fragrance characteristics (singularities/peculiarities to the fragrance), or (and) even to serve as inspiration for product creations with olfactory descriptions of natural products. Croton tricolor (Euphorbiaceae), accordingly to an initial evaluation of a perfumer, presented excellent olfactory characteristics, which facilitated its use in the studies. The analysis of the C. tricolor essential oil by gas chromatography with flame ionization detector (GC/FID) and gas chromatography coupled to mass spectrometry (GC/MS) allowed to quantify and identify their main markers, as well as to use this information to construct an olfactory accord that reproduces the odor of natural products. The C. tricolor essential oil had as main components bicyclogermacrene (15.4%), spathulenol (10.5%) and alpha pinene (6.8%). From these data, an aromatic accord was created reproducing the original odor containing alpha pinene (7%), phenethyl alcohol (5%), cedar oil (5%), orange oil (0.5%), limonene (1%), eucalyptol (0.5%) and nerolidol (0.3%). Some of the major compounds, bicyclogermacrene and spatulenol, could not be added because they were not commercially available. In these cases (therefore), other products (raw materials) with similar olfactory characteristics (olfactory profile) and commercially viable (offered on the market) were used, such as the use of phenethyl alcohol, cedar oil and orange oil in the accord creation. The results showed that accord creation is an economically viable method for the reproduction of natural odors that can be used in fragrance formulations and may help to solve problems that exist in the production and commercialization of essential oils such as production seasonality and reproducibility


Subject(s)
Perfume/chemistry , Oils, Volatile/analysis , Euphorbiaceae/anatomy & histology , Cosmetic Industry , Gas Chromatography-Mass Spectrometry/methods , Odorants
13.
Article in Korean | WPRIM | ID: wpr-786286

ABSTRACT

BACKGROUND: The purpose of this study was to determine the degree of oral care, perceived halitosis, halitosis, interpersonal relationships and oral health-related quality of life and to examine the relationships among these variables.METHODS: The participants were 94 elderly people. The questionnaire included questions on oral care, perceived halitosis, interpersonal relationships, and oral health-related quality of life. Halitosis was measured using odor breath tester.RESULTS: A total of 63.8% of the elderly did not receive regular oral care. The halitosis score was 1.59, thus indicating moderate halitosis. The current perceived halitosis figure was 1.54, participants responded that they feel slight. There was no significant correlation between halitosis and perceived halitosis. Furthermore, there was no significant difference in halitosis and perceived halitosis according to the oral care. Perceived halitosis was negatively correlated with oral health-related quality of life. Interpersonal relationships were correlated with oral health-related quality of life.CONCLUSIONS: It is necessary to actively promote the need for oral care among the elderly. Moreover, older people need regular oral care to prevent halitosis and improve their oral health-related quality of life.


Subject(s)
Aged , Breath Tests , Halitosis , Humans , Odorants , Oral Hygiene , Quality of Life
14.
Article in Korean | WPRIM | ID: wpr-764031

ABSTRACT

Halitosis is a very common disease that affects the majority of the population and is characterized by unpleasant odor during expiration. Anaerobic bacteria produce a range of malodorous substances including volatile sulfur compounds. To reduce oral malodor, the amount of oral microorganisms should be managed through brushing, scraping, and use of antibacterial agents. In this study, a mouthwash containing 0.05% cetylpyridinium chloride was tested on 22 candidates with oral malodor for two weeks to confirm oral malodor reduction through the use of antibacterial mouthwashes. Volatile sulfur compound measurements were significantly lower after using the mouthwash than before using it; thus, the mouthwash effectively reduced oral malodor.


Subject(s)
Anti-Bacterial Agents , Bacteria , Bacteria, Anaerobic , Cetylpyridinium , Halitosis , Mouth , Mouthwashes , Odorants , Sterilization , Sulfur , Sulfur Compounds
15.
Article in English | WPRIM | ID: wpr-758892

ABSTRACT

We prepared a polymorphic form of valnemulin hydrogen tartrate (Form I) to overcome the instability and irritating odor of valnemulin hydrochloride that affect its use in the production and application of veterinary drugs. The physicochemical properties of Form I were characterized by scanning electron microscopy, X-ray powder diffraction, infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. The results showed the crystal structure and thermal properties of Form I were very different from those of a commercially available form of valnemulin hydrogen tartrate (Form II). Form I and Form II were more stable than valnemulin hydrochloride after storage under irradiation and high humidity conditions, respectively. The solubility of Form I was 2.6 times that of Form II, and Form I was selected for use in pharmaceutical kinetics experiments in vivo. Compared to valnemulin hydrochloride, after oral administration at a dose of 10 mg/kg in pigs, Form I had similar pharmaceutical kinetic behavior but a slightly higher area under the concentration–time curve from time zero to the last measurable concentration. Consequently, Form I should be suitable for the development of simple formulations and be effective in the clinical application of veterinary drugs.


Subject(s)
Administration, Oral , Calorimetry, Differential Scanning , Humidity , Hydrogen , Kinetics , Microscopy, Electron, Scanning , Odorants , Pharmacokinetics , Powder Diffraction , Solubility , Spectrum Analysis , Swine , Veterinary Drugs
16.
Safety and Health at Work ; : 362-369, 2019.
Article in English | WPRIM | ID: wpr-761364

ABSTRACT

BACKGROUND: Chronic nonspecific symptoms attributed to indoor nonindustrial work environments are common and may cause disability, but the medical nature of this disability is unclear. The aim was to medically characterize the disability manifested by chronic, recurrent symptoms and restrictions to work participation attributed to low-level indoor pollutants at workplace and whether the condition shares features with idiopathic environmental intolerance. METHODS: We investigated 12 patients with indoor air–related work disability. The examinations included somatic, psychological, and psychiatric evaluations as well as investigations of the autonomic nervous system, cortisol measurements, lung function, and allergy tests. We evaluated well-being, health, disability, insomnia, pain, anxiety, depression, and burnout via questionnaires. RESULTS: The mean symptom history was 10.5 years; for disabling symptoms, 2.7 years. Eleven patients reported reactions triggered mainly by indoor molds, one by fragrances only. Ten reported sensitivity to odorous chemicals, and three, electric devices. Nearly all had co-occurrent somatic and psychiatric diagnoses and signs of pain, insomnia, burnout, and/or elevated sympathetic responses. Avoiding certain environments had led to restrictions in several life areas. On self-assessment scales, disability showed higher severity and anxiety showed lower severity than in physician assessments. CONCLUSION: No medical cause was found to explain the disability. Findings support that the condition is a form of idiopathic environmental intolerance and belongs to functional somatic syndromes. Instead of endless avoidance, rehabilitation approaches of functional somatic syndromes are applicable.


Subject(s)
Anxiety , Autonomic Nervous System , Depression , Disability Evaluation , Fungi , Humans , Hydrocortisone , Hypersensitivity , Lung , Multiple Chemical Sensitivity , Odorants , Rehabilitation , Self-Assessment , Sleep Initiation and Maintenance Disorders , Weights and Measures
19.
Electron. j. biotechnol ; 36: 1-8, nov. 2018. ilus, graf
Article in English | LILACS | ID: biblio-1047976

ABSTRACT

Background: Osmanthus fragrans is an important ornamental tree and has been widely planted in China because of its pleasant aroma, which is mainly due to terpenes. The monoterpenoid and sesquiterpenoid metabolic pathways of sweet osmanthus have been well studied. However, these studies were mainly focused on volatile small molecule compounds. The molecular regulation mechanism of synthesis of large molecule compounds (triterpenoids) remains unclear. Squalene synthase (SQS), squalene epoxidase (SQE), and beta-amyrin synthase (BETA-AS) are three critical enzymes of the triterpenoid biosynthesis pathway. Results: In this study, the full-length cDNA and gDNA sequences of OfSQS, OfSQE, and OfBETA-AS were isolated from sweet osmanthus. Phylogenetic analysis suggested that OfSQS and OfSQE had the closest relationship with Sesamum indicum, and OfBETA-AS sequence shared the highest similarity of 99% with that of Olea europaea. The qRT-PCR analysis revealed that the three genes were highly expressed in flowers, especially OfSQE and OfBETA-AS, which were predominantly expressed in the flowers of both "Boye" and "Rixiang" cultivars, suggesting that they might play important roles in the accumulation of triterpenoids in flowers of O. fragrans. Furthermore, the expression of OfBETA-AS in the two cultivars was significantly different during all the five flowering stages; this suggested that OfBETA-AS may be the critical gene for the differences in the accumulation of triterpenoids. Conclusion: The evidence indicates that OfBETA-AS could be the key gene in the triterpenoid synthesis pathway, and it could also be used as a critical gene resource in the synthesis of essential oils by using bioengineered bacteria.


Subject(s)
Triterpenes/metabolism , Cloning, Molecular , Oleaceae/genetics , Farnesyl-Diphosphate Farnesyltransferase/metabolism , Oils, Volatile , Gene Expression , Polymerase Chain Reaction , Oleaceae/enzymology , Squalene Monooxygenase/metabolism , Odorants
20.
Rev. bras. enferm ; 71(5): 2552-2560, Sep.-Oct. 2018. tab, graf
Article in English | LILACS, BDENF | ID: biblio-958702

ABSTRACT

ABSTRACT Objective: Checking for the existence of assessment instruments for odor in neoplastic wounds. Method: Integrative review performed in the databases Lilacs, SCiELO, Ibecs and MedLine, including national and international publications. Results: 15 articles were analyzed, in its majority performed by nurses and being of the revision type. Nine scales were found, of which the majority assesses only the odor intensity. The scale most used to evaluate products and/or bandage covers for neoplastic injuries was the Odor Evaluation Guideline, of qualitative-quantitative nature, that establishes the symptom within four levels; only one of which being validated (Teler scale). Conclusion: The results of this study showed that, currently, there is only one scale that is validated for assessing odor in neoplastic wounds, pointing towards the need to develop new instruments that incorporate validated and reliable instruments in clinical practice.


RESUMEN Objetivo: Verificar la existencia de instrumentos de evaluación del olor en heridas neoplásicas. Método: Revisión integrativa realizada en las bases de datos Lilacs, SCiELO, Ibecs y MedLine, incluyendo las publicaciones nacionales e internacionales. Resultados: Se analizaron 15 artículos, en su mayoría realizados por enfermeros y del tipo revisión Se encontraron nueve escalas, de las cuales gran parte evalúa sólo la intensidad del olor. La escala más utilizada para evaluar productos y/o coberturas en los curativos de heridas neoplásicas fue la guía de evaluación del olor, de naturaleza cuali-cuantitativa, que puntualiza el síntoma en cuatro niveles; y sólo una era validada (escala de Teler). Conclusión: Los resultados mostraron que hasta el momento sólo existe una escala de evaluación del olor en heridas neoplásicas validada, apuntando a la necesidad de desarrollar nuevas herramientas que incorporen instrumentos validados y confiables en la práctica clínica.


RESUMO Objetivo: Verificar a existência de instrumentos de avaliação do odor em feridas neoplásicas. Método: Revisão integrativa realizada nas bases de dados Lilacs, SCiELO, Ibecs e MedLine, incluindo publicações nacionais e internacionais. Resultados: Foram analisados 15 artigos, em sua maioria realizados por enfermeiros e do tipo revisão. Foram encontradas nove escalas, das quais a maioria avalia apenas a intensidade do odor. A escala mais utilizada para avaliar produtos e/ou coberturas nos curativos de feridas neoplásicas foi o guia de avaliação do odor, de natureza quali-quantitativa, que pontua o sintoma em quatro níveis; e apenas uma delas era validada (escala de Teler). Conclusão: Os resultados deste estudo demonstraram que até o momento só existe uma escala de avaliação do odor em feridas neoplásicas validada, apontando para necessidade de desenvolvimento de novas ferramentas que incorporem na prática clínica instrumentos validados e confiáveis.


Subject(s)
Humans , Wound Healing , Neoplasms/complications , Odorants/analysis , Evaluation Studies as Topic , Neoplasms/physiopathology
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