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Int. braz. j. urol ; 47(6): 1279-1280, Nov.-Dec. 2021.
Article in English | LILACS | ID: biblio-1340031


ABSTRACT Introduction: Salvage Radical Prostatectomy after radiation therapy is challenging and associated with high rates of serious complications (1, 2). The novel Retzius-Sparing RARP (RS-RARP) approach has shown excellent continence outcomes (3, 4). Purpose: To describe step-by-step our Salvage Retzius-Sparing RARP (sRS-RARP) operative technique and report feasibility, safety and the preliminary oncological and continence outcomes in the post-radiation scenario. Materials and Methods: Twelve males presenting local prostate cancer recurrence after radiotherapy that underwent sRS-RARP were included. All patients performed preoperative multiparametric MRI and PSMA-PET. Surgical technique: 7cm peritoneum opening at Douglas pouch, Recto-prostatic space development, Seminal vesicles and vas deferens isolation and section, Extra-fascial dissection through peri-prostatic fat, Neurovascular bundle control, Bladder neck total preservation and opening, Anterior dissection at Santorini plexus plane, Apex dissection with urethra preservation and section, Prostate release, Vesicouretral modified Van Velthoveen anastomosis, Rocco Stitch, Oncological and continence outcomes reported with minimum 1-year follow-up. Results: Ten patients had previously received external beam radiation (EBR) whereas two received previous brachytherapy plus EBR. At 1, 3 and 12 months after surgery, 25%, 75% and 91.6% of the men used one safety pad or less, respectively. No major complications or blood transfusions were reported. Final pathology reported pT2b 41.6%, pT2c 33.3% and pT3a 25%, positive surgical margins 25%, positive lymph nodes were not found, biochemical recurrence 16.6%. Conclusion: Salvage Retzius-Sparing Robotic Assisted Radical Prostatectomy approach appears to be technically feasible and oncologically safe with potential to provide better continence outcomes.

Humans , Male , Prostatic Neoplasms/surgery , Robotic Surgical Procedures , Prostate , Prostatectomy , Brazil , Treatment Outcome , Organ Sparing Treatments
Int. braz. j. urol ; 46(2): 169-184, Mar.-Apr. 2020. tab, graf
Article in English | LILACS | ID: biblio-1090578


ABSTRACT Background Standard management of muscle-invasive bladder cancer involves radical cystectomy with pelvic lymph node dissection. However, patients may be ineligible for surgery or may wish to avoid the morbidity of cystectomy due to quality of life concerns. Bladder preservation therapies have emerged as alternatives treatment options that can provide comparable oncologic outcomes while maintaining patients' quality of life. Objective To review bladder preservation therapies, patient selection criteria, and functional and oncologic outcomes for BPT in muscle-invasive bladder cancer. Materials and Methods We conducted a comprehensive literature review of bladder preservation therapies in Pubmed and Embase. Discussion The ideal patient for BPT has low-volume T2 disease, absence of CIS, absence of hydronephrosis, and a maximal TURBT with regular surveillance. Technological advancements involving cancer staging, TURBT technique, and chemotherapy and radiation therapy regimens have improved BPT outcomes, with oncologic outcomes now comparable to those of radical cystectomy. Advancements in BPT also includes a heightened focus on improving quality of life for patients undergoing bladder preservation. Preservation strategies with most evidence for use include trimodality therapy and partial cystectomy with pelvic lymph node dissection. Conclusions This review highlights the breadth of strategies that aim to preserve a patient's bladder while still optimizing local tumor control and overall survival. Future areas for innovation include the use of predictive biomarkers and implementation of immunotherapy, moving the field towards patient-tailored care.

Humans , Urinary Bladder Neoplasms/surgery , Cystectomy/methods , Urinary Bladder Neoplasms/pathology , Combined Modality Therapy , Organ Sparing Treatments , Neoplasm Invasiveness , Neoplasm Staging
Chinese Journal of Traumatology ; (6): 149-151, 2020.
Article in English | WPRIM | ID: wpr-827841


Adrenal gland trauma is a rare phenomenon, due to the small size and retroperitoneal location of the organ. The majority of adrenal gland trauma is due to blunt force injury and is only rarely encountered due to the penetrating mechanisms. A 20-year-old male sustained a gunshot wound to the left abdomen. Upon exploration, he was found to have a through and through injury to the left adrenal gland, among other injuries. Injury to the adrenal gland due to penetrating trauma is exceptionally rare. The principles of management are to control bleeding from the gland with debridement and hemostasis rather than attempt to resect the entire organ. The management of a penetrating injury to the adrenal gland is straightforward and should not be a contributor to a patient's morbidity or mortality.

Adrenal Glands , Diagnostic Imaging , Wounds and Injuries , Adult , Debridement , Hemorrhage , Therapeutics , Hemostasis, Surgical , Humans , Laparotomy , Male , Multiple Trauma , Therapeutics , Organ Sparing Treatments , Methods , Tomography, X-Ray Computed , Treatment Outcome , Wounds, Gunshot , Diagnostic Imaging , Therapeutics , Young Adult
Rev. bras. ginecol. obstet ; 41(11): 673-678, Nov. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057880


Abstract Objective To evaluate whether the use of intraoperative ultrasound leads to more conservative surgeries for benign ovarian tumors. Methods Women who underwent surgery between 2007 and 2017 for benign ovarian tumors were retrospectively analyzed. The women were classified into two groups: those who underwent intraoperative ultrasound (group A) and those who did not (group B). In group A, minimally-invasive surgery was performed for most patients (a specific laparoscopic ultrasound probe was used), and four patients were submitted to laparotomy (a linear ultrasound probe was used). The primary endpoint was ovarian sparing surgery (oophoroplasty). Results Among the 82 cases identified, only 36 met the inclusion criteria for the present study. Out of these cases, 25 underwent intraoperative ultrasound, and 11 did not. There were no significant differences in arterial hypertension, diabetes, smoking history, and body mass index for the two groups (p=0.450). Tumor diameter was also similar for both groups, ranging from 1 cm to 11 cm in group A and from 1.3 cm to 10 cm in group B (p=0.594). Tumor histology confirmed mature teratomas for all of the cases in group B and for 68.0% of the cases in group A. When the intraoperative ultrasound was performed, a more conservative surgery was performed (p<0.001). Conclusion The use of intraoperative ultrasound resulted in more conservative surgeries for the resection of benign ovarian tumors at our center.

Resumo Objetivo Avaliar se o uso do ultrassom intraoperatório leva a cirurgias mais conservadoras para tumores ovarianos benignos. Métodos Mulheres que foram submetidas a cirurgia entre 2007 e 2017 por tumores ovarianos benignos foram analisadas retrospectivamente. As mulheres foram classificadas em dois grupos: aquelas que foram submetidas ao ultrassom intraoperatório (grupo A), e aquelas que não o foram (grupo B). No grupo A, foi realizada cirurgia minimamente invasiva na maioria das pacientes (foi usada sonda ultrassonográfica laparoscópica específica), e quatro pacientes foram submetidas a laparotomia (foi usada sonda ultrassonográfica linear). O desfecho primário foi a cirurgia preservadora do ovário (ooforoplastia). Resultados Entre os 82 casos identificados, somente 36 atenderam aos critérios de inclusão para este estudo. Destes, 25 pacientes foram submetidas ao ultrassom intraoperatório, e 11 não o foram. Não houve diferenças significantes em relação à pressão arterial, diabetes, tabagismo e índice de massa corporal entre os dois grupos (p=0.450). O diâmetro do tumor também foi similar entre os dois grupos, variando de 1cm a 11cm no grupo A, e de 1,3cma 10cm no grupo B (p=0.594). A histologia dos tumores confirmou teratoma maduro para todos os casos do grupo B, e para 68,0% dos casos do grupo A. Mais cirurgias conservadoras foram realizadas quando o ultrassom intraoperatório foi realizado (p<0.001). Conclusão O uso do ultrassom intraoperatório resultou em mais cirurgias conservadoras na ressecção de tumores benignos do ovário em nossa instituição.

Humans , Female , Adolescent , Adult , Young Adult , Ovarian Neoplasms/surgery , Ovarian Neoplasms/diagnostic imaging , Intraoperative Care/methods , Ovarian Neoplasms/pathology , Ovary/surgery , Retrospective Studies , Ultrasonography , Laparoscopy , Organ Sparing Treatments , Conservative Treatment
Rev. bras. ginecol. obstet ; 41(3): 176-182, Mar. 2019. tab
Article in English | LILACS | ID: biblio-1003547


Abstract Objective The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym). Methods The present retrospective study analyzed data obtained from clinical and histopathological reports of women with BOTs treated in a single cancer center between 2010 and 2018. Results A total of 57 women were included, with a mean age of 48.42 years old (15.43- 80.77), of which 30 (52.63%) were postmenopausal, and 18 (31.58%) were < 40 years old. All of the women underwent surgery. A total of 37 women (64.91%) were submitted to complete surgical staging for BOT, and none (0/57) were submitted to pelvic or paraortic lymphadenectomy. Chemotherapy was administered for two patients who recurred. The final histological diagnoses were: serous in 20 (35.09%) cases, mucinous in 26 (45.61%), seromucinous in 10 (17.54%), and endometrioid in 1 (1.75%) case. Intraoperative analyses of frozen sections were obtained in 42 (73.68%) women, of which 28 (66.67%) matched with the final diagnosis. The mean follow-up was of 42.79 months (range: 2.03-104.87 months). Regard ingthe current status of the women, 45(78.95%) are alive without disease, 2(3.51%) arealive with disease, 9 (15.79%) had their last follow-up visit > 1 year beforethe performanceof the present study but arealive, and 1 patient(1.75%) died of another cause. Conclusion Women in the present study were treated according to the current guidelines and only two patients recurred.

Resumo Objetivo O objetivo do presente estudo foi descrever uma série de 57 mulheres com tumores borderline de ovário (TBO) em relação às características histológicas, clínicas, e ao manejo do tratamento realizado no Departamento de Obstetrícia e Ginecologia da Universidade Estadual de Campinas (Unicamp). Métodos O presente estudo retrospectivo analisou dados obtidos dos registros clínicos e histopatológicos de mulheres com TBO tratadas em um único centro oncológico de 2010 a 2018. Resultados Um total de 57 mulheres foram incluídas, com uma média de idade de 48,42 anos (15,43-80,77), das quais 30 (52,63%) eram menopausadas, e 18 (31,58%) tinham < 40 anos. Todas as mulheres foram operadas. Um total de 37 mulheres (64,91%) foram submetidas a cirurgia de estadiamento completo para TBO, e nenhuma foi submetida a linfadenectomia pélvica ou paraórtica. O tratamento com quimioterapia foi administrado em duas pacientes que recidivaram. Os diagnósticos histológicos finais foram: seroso em 20 mulheres (35,09%), mucinoso em 26 (45,61%), seromucinoso em 10 (17,54%) e endometrióide em 1 (1,75%). A avaliação histológica intraoperatória foi realizada em 42 (73,68%) das mulheres, das quais 28 (66,67%) foram compatíveis com os diagnósticos finais. O tempo médio de seguimento foi de 42,79 meses (variando de 2,03 a 104,87 meses). Em relação ao status atual das mulheres, 45 (78.95%) estão vivas sem doença, 2 (3,51%) estão vivas com doença, 9 (15.79%) tiveram a última consulta de seguimento há > 1 ano antes da realização do presente estudo, mas estão vivas, e 1 paciente faleceu por outra causa. Conclusão As mulheres do presente estudo foram tratadas de acordo com as recomendações atuais e apenas duas mulheres apresentaram recorrência.

Humans , Female , Adolescent , Adult , Aged , Aged, 80 and over , Young Adult , Ovarian Neoplasms/pathology , Precancerous Conditions/pathology , Ovarian Neoplasms/surgery , Ovarian Neoplasms/drug therapy , Precancerous Conditions/surgery , Precancerous Conditions/drug therapy , Brazil , Cancer Care Facilities/statistics & numerical data , Menopause/physiology , Retrospective Studies , Treatment Outcome , Age Distribution , Organ Sparing Treatments/statistics & numerical data , Salpingo-oophorectomy/statistics & numerical data , Hysterectomy/statistics & numerical data , Middle Aged , Neoplasm Recurrence, Local/etiology , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/drug therapy , Antineoplastic Agents/therapeutic use
Rev. chil. cir ; 71(1): 42-46, feb. 2019. tab
Article in Spanish | LILACS | ID: biblio-985377


Resumen Introducción: Las técnicas quirúrgicas para la fístula perianal compleja han tenido altas tasas de recidiva asociado al riesgo de incontinencia fecal. La técnica de LIFT (Ligadura Interesfintérica del trayecto fistuloso) ha logrado menores tasas de recidiva con casi nulo riesgo de incontinencia según reportes inter-nacionales. Sin embargo, aún no está consolidada como técnica estándar para esta patología. Objetivo: Presentar los resultados (éxito clínico e incontinencia según escala de Wexner) de nuestros pacientes con fístula perianal compleja operados con técnica de LIFT. Materiales y Método: Estudio descriptivo de cohorte prospectiva no aleatoria, con pacientes operados por fístula perianal compleja en el Hospital del Salvador, entre los años 2015 al 2017. Resultados: Se incluyen 22 pacientes operados. En un 77% se obtiene éxito terapéutico en la primera cirugía y hasta un 90% con una segunda cirugía más simple. Ninguno de los pacientes modificó su Wexner preoperatorio. Conclusiones: En pacientes con fístula perianal compleja la técnica de LIFT es una alternativa que ofrece igual o mejores tasas de curación clínica con bajo riesgo de incontinencia fecal.

Introduction: Surgical techniques for complex perianal fistula have high recurrence and fecal incontinence rates. The technique of LIFT (ligation of the intersphincteric fistula tract) has achieved lower rates of recurrence with almost no risk of incontinence according to international reports. However, it is not yet consolidated as a standard technique for this pathology. Objective: To present the results (clinical success and incontinence according to the Wexner scale) of our patients with complex perianal fistula operated with the LIFT technique. Materials and Method: Descriptive study of a non-randomized prospective cohort, with patients operated for complex perianal fistula at the Hospital del Salvador, between 2015 and 2017. Results: 22 operated patients are included. In 77%, therapeutic success is obtained in the first surgery and up to 90% with a second surgery. None of this patients modified their preoperative Wexner. Conclusions: In patients with complex perianal fistula, the LIFT technique is an alternative that offers high cure rates with low risk of fecal incontinence.

Humans , Male , Female , Adult , Middle Aged , Aged , Rectal Fistula/surgery , Ligation/adverse effects , Ligation/methods , Anal Canal/surgery , Postoperative Complications/etiology , Reoperation , Treatment Outcome , Organ Sparing Treatments/methods
Article in English | WPRIM | ID: wpr-764522


OBJECTIVE: This study aims to evaluate the effects and pregnancy outcomes of gonadotropin-releasing hormone agonist (GnRH agonist) combined with aromatase inhibitor (AI) in preserving the fertility of obese women with grade 1 endometrial cancer (EC). METHODS: This study recruited obese EC patients who wished to preserve their fertility. The treatment regimen consisted of intramuscular GnRH agonist 3.75 mg every 4 weeks and oral AI 2.5 mg daily. The maintenance regimen was the same as the initial treatment regimen. Primary outcomes included response rate, time to complete response (CR), and time to recurrence; pregnancy outcomes included the time to pregnancy, pregnancy rate and live birth rate. RESULTS: Six obese patients with EC were included in this study, with the age (mean±standard deviation [SD]) of 30.5±3.3 years and body mass index (mean±SD) of 35.0±1.4 kg/m2. CR rate was 100%, and time to CR was 3–6 months. None of the patients had recurrence after a median follow-up of 4.0 years (range, 1.3–7.0 years). The most common side effects were menopause-like symptoms. Among these patients, no weight gain was observed during treatment. The pregnancy rate and live birth rate was 50.0% and 75.0%, respectively, with a median time to pregnancy of 2.4 years (range, 1.0–5.5 years). CONCLUSION: The combination of GnRH agonist and AI demonstrated promising long-term effect in young obese EC patients who wished to preserve their fertility. No weight gain side effects were observed. Further studies with a larger sample size are needed to fully evaluate this novel treatment regimen.

Aromatase Inhibitors , Aromatase , Body Mass Index , Endometrial Neoplasms , Female , Fertility , Follow-Up Studies , Gonadotropin-Releasing Hormone , Humans , Live Birth , Obesity , Organ Sparing Treatments , Pilot Projects , Pregnancy , Pregnancy Outcome , Pregnancy Rate , Recurrence , Sample Size , Time-to-Pregnancy , Weight Gain
Rev. bras. ginecol. obstet ; 40(10): 642-646, Oct. 2018. graf
Article in English | LILACS | ID: biblio-977780


Abstract Transverse vaginal septum is a rare female genital tract anomaly, and little is described about its surgical treatment. We report the case of a patient who wished to preserve hymenal integrity due to social and cultural beliefs. We performed a vaginoscopic resection of the septum under laparoscopic view, followed by the introduction of a Foley catheter in the vagina, thus preserving the hymen. After 12 months of follow-up, no septal closure was present, and the menstrual flow was effective. Vaginoscopic hysteroscopy is an effectivemethod of vaginal septum resection, even in cases in which hymenal integrity must be preserved due to social and cultural beliefs.

Resumo Septo vaginal transverso é uma anomalia rara do trato genital feminino, e pouco é descrito sobre o tratamento cirúrgico. Relatamos o caso de uma paciente que desejava preservar a integridade do hímen devido a crenças sociais e culturais. Realizamos ressecção vaginoscópica do septo sob visão laparoscópica, seguida da introdução de um cateter de Foley na vagina, preservando assim o hímen. Após 12 meses de acompanhamento, não havia fechamento do septo, e o fluxo menstrual era eficaz. A histeroscopia vaginoscópica é um método eficaz de ressecção dos septos vaginais, incluindo os casosemque a integridade do hímen deve ser mantida devido a crenças sociais e culturais.

Humans , Female , Adolescent , Vagina/abnormalities , Vagina/surgery , Hysteroscopy/methods , Organ Sparing Treatments/methods , Hymen
Acta cir. bras ; 33(9): 834-841, Sept. 2018. graf
Article in English | LILACS | ID: biblio-973495


Abstract Purpose: To evaluate the outcome of transhiatal esophagectomy without thoracotomy and with preservation of the vagal trunks for the treatment of advanced megaesophagus. Methods: Between March 2006 and September 2017, it was performed 136 transhiatal esophagectomies without thoracotomy by laparoscopy, with preservation of the vagus nerves. All patients were evaluated pre and postoperatively for respiratory and nutritional aspects Post operatively, some surgical aspects were evaluated like radiology and endoscopy of the digestive tract. Results: Follow-up for 7 months to 12 years by clinical, radiologic, endoscopic and pH monitoring revealed satisfactory and encouraging outcomes of the procedure. Conclusion: The laparoscopic transhiatal esophagectomy is a feasible and safe technique with good postoperative outcomes.

Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Vagus Nerve , Esophageal Achalasia/surgery , Laparoscopy/methods , Organ Sparing Treatments , Severity of Illness Index , Follow-Up Studies , Treatment Outcome , Esophagectomy/methods
Arq. gastroenterol ; 55(2): 154-159, Apr.-June 2018. tab
Article in English | LILACS | ID: biblio-950514


ABSTRACT BACKGROUND: The treatment of median and distal rectal cancer has evolved a lot in the last decades due to the dissemination of the technique of total mesortal excision and the use of neoadjuvant chemotherapy and radiotherapy. However, this multidisciplinary approach can affect patients' quality of life in a number of ways that deserve to be adequately assessed. OBJECTIVE: To evaluate immediate and late health related quality of life in patients with rectal cancer treated with curative intent. METHODS: Prospective study including patients with non-metastatic mid or low rectal cancer. EORTC QLQ-C30 and EORTC-CR38 questionnaires were applied before, 3 months and 12 months after treatment. The mean scores of the questionnaires were stratified into 4 categories for the purpose of comparing the results at different moments. RESULTS: Twenty nine patients completed the 1st and 2nd questionnaires and 12 completed the three questionaries. Patient´s mean age was 50.8 years and 62% were female. Sphincter preservation was possible in 89.6%. Overall health scores and quality of life improved after three months after 12 months. After three months, sexual satisfaction, female sexual problems and future perspective were worsen, but gastrointestinal symptoms, sphincter problems, and weight loss were improved. After 12 months the Future Perspective deteriorated, but there was improvement of the problems related to stoma, sphincter problems and body image. CONCLUSION: Despite the complexity of the treatment of rectal cancer within a specialized service, quality of life was preserved and was satisfactory in most of the studied aspects.

RESUMO CONTEXTO: O tratamento do câncer de reto médio e distal evoluiu muito nas últimas décadas devido à disseminação da técnica de excisão total do mesorretal e ao uso de quimioterapia e radioterapia neoadjuvantes. No entanto, essa abordagem multidisciplinar pode afetar a qualidade de vida dos pacientes de várias maneiras que merecem ser adequadamente avaliadas. OBJETIVO: Avaliar a qualidade de vida imediata e tardia relacionada à saúde em pacientes tratados de câncer retal com intenção curativa. MÉTODOS: Estudo prospectivo que incluiu pacientes com câncer primário de reto médio ou baixo não metastático. Foram aplicados os questionários EORTC QLQ-C30 e EORTC-CR38 antes, 3 meses e 12 meses após o tratamento. As médias dos escores dos questionários foram estratificadas em quatro categorias para fins de comparação dos resultados nos diferentes momentos. RESULTADOS: Vinte e nove pacientes responderam aos 1º e 2º questionários e 12 responderam os três questionários. A idade média foi de 50,8 anos e 62% do sexo feminino. Preservação esfincteriana foi possível em 89,6%. As médias de escores globais de saúde e qualidade de vida melhoraram tanto após 3 meses quanto após 12 meses. Função cognitiva, dor, insônia, constipação, sintomas gastrointestinais, problemas esfincterianos, perda de peso melhoraram tanto no período imediato quanto tardio. Problemas sexuais masculinos e femininos e perspectiva futura pioraram tanto no período precoce quanto tardio. As demais funções ou sintomas ou itens não se alteraram. CONCLUSÃO: Apesar da complexidade do tratamento do câncer de reto dentro de um serviço especializado, a qualidade de vida ficou preservada ou melhor na maioria das características estudadas.

Humans , Male , Female , Adolescent , Adult , Young Adult , Quality of Life/psychology , Rectal Neoplasms/surgery , Anal Canal , Rectal Neoplasms/psychology , Health Status , Interviews as Topic , Prospective Studies , Surveys and Questionnaires , Treatment Outcome , Organ Sparing Treatments , Middle Aged
Int. braz. j. urol ; 44(3): 475-482, May-June 2018. tab, graf
Article in English | LILACS | ID: biblio-954049


ABSTRACT Objectives: The clinical significance of positive surgical margin (PSM) after a Nephron Sparing Surgery (NSS) is controversial. The aim of this study is to evaluate the association between PSM and the risk of disease recurrence in patients with pT1 kidney tumors who underwent NSS. Materials and Methods: Retrospective cohort study. A total of 314 patients submitted to a NSS due to stage pT1 renal tumor between January 2010 and June 2015 were included. Recurrence-free survival was estimated. The Cox model was used to adjust the tumor size, histological grade, pathological stage, age, surgical margins and type of approach. Results: Overall PSM was 6.3% (n=22). Recurrence was evidenced in 9.1% (n=2) of patients with PSM and 3.5% (n=10) for the group of negative surgical margin (NSM). The estimated local recurrence-free survival rate at 3 years was 96.4% (95% CI 91.9 to 100) for the NSM group and 87.8% (95% CI 71.9 to 100) for PSM group (p=0.02) with no difference in metastasis-free survival. The PSM and pathological high grade (Fuhrman grade III or IV) were independent predictors of local recurrence in the multivariate analysis (HR 12.9, 95%CI 1.8-94, p=0.011 / HR 38.3, 95%CI 3.1-467, p=0.004 respectively). Fuhrman grade proved to be predictor of distant recurrence (HR 8.1, 95%CI 1.6-39.7, p=0.011). Conclusions: The PSM in pT1 renal tumors showed to have higher risk of local recurrence and thus, worse oncological prognosis.

Humans , Male , Female , Adult , Aged , Carcinoma, Renal Cell/surgery , Organ Sparing Treatments/methods , Margins of Excision , Kidney Neoplasms/surgery , Neoplasm Recurrence, Local/diagnosis , Time Factors , Carcinoma, Renal Cell/pathology , Predictive Value of Tests , Reproducibility of Results , Retrospective Studies , Treatment Outcome , Risk Assessment/methods , Disease-Free Survival , Tumor Burden , Neoplasm Grading , Kidney Neoplasms/pathology , Middle Aged , Neoplasm Recurrence, Local/pathology , Neoplasm Staging , Nephrectomy/methods
Rev. chil. cir ; 70(2): 178-184, 2018. tab, ilus
Article in Spanish | LILACS | ID: biblio-959368


Resumen Tras múltiples intentos para lograr resultados apropiados en una resección quirúrgica por cáncer de recto, Sir William Ernest Miles desarrolla la técnica que posteriormente llevará su nombre, y que se conoce actualmente, sin muchas modificaciones, como resección abdominoperineal. Esta técnica, considerada el gold standard para tumores de recto por muchos años, fue progresivamente reemplazada por las técnicas de preservación de esfínter. La resección anterior baja permitió preservar el esfínter a paciente con tumores de recto a más de 5 cm del margen anal. El desarrollo técnico (suturas grapadas), mejor entendimiento de principios oncológicos (resección total del mesorrecto) y la introducción de la neoadyuvancia con quimioradioterapia, permitió bajar el margen de sección distal considerado adecuado y realizar anastomosis colorrectales ultrabajas y coloanales. La resección ultrabaja interesfintérica reseca el esfínter anal interno (en forma total, subtotal o parcial) logrando evitar la colostomía permanente en un grupo de pacientes. Esta técnica, ha sido ampliamente estudiada con resultados oncológicos publicados que resultan mejores o similares que los de la resección abdominoperineal. Actualmente la evaluación de respuesta a neoadyuvancia, ha llevado a algunos grupos de trabajo a plantear la preservación del órgano; ya sea mediante el seguimiento estricto tras respuesta clínica completa, como técnicas de resección local en respuesta incompleta.

After multiple attempts to achieve appropriate results in the surgical resection for rectal cancer, Sir William Ernest Miles develops the technique that would carry his name, and is, without modifications, currently referred as abdominoperineal resection. This technique, considered gold standard for rectal tumors for many years, has been gradually replaced by sphincter preserving surgery. Low anterior resection allowed sphincter-preservation in patients with low rectal tumors within 5 cm from the anal verge. Technical developments (double stapling technique), better understanding of oncological principles (total mesorectal excision) and the introduction of neoadyuvant treatment with chemoradiotherapy, allowed further lowering of the adequate distal resection margin and to carry out ultralow colorectal and coloanal anastomoses. Ultralow intersphincteric resection removes the internal anal sphincter (partial, subtotal or total resection) avoiding permanent colostomy in a subset of patients. This technique has been broadly studied with published oncological outcomes that are better or similar to those of abdominoperineal resection. Currently, evaluation of response after neoadyuvant therapy has led some working groups to propose organ preservation; either by strict follow up for complete clinical response, or by local excision techniques for incomplete clinical response.

Humans , Anal Canal/surgery , Rectal Neoplasms/surgery , Organ Sparing Treatments/methods
ABCD arq. bras. cir. dig ; 31(3): e1395, 2018. tab, graf
Article in English | LILACS | ID: biblio-949249


ABSTRACT Background: Laparoscopic distal pancreatectomy has been the choice for resection of distal pancreas lesions due many advantages over open approach. Spleen preservation technique seems minimizes infectious complications in long-term outcome. Aim: To present the results of laparoscopic distal pancreatectomies with spleen preservation by Kimura´s technique (preservation of spleen blood vessels) performed by single surgical team. Methods: Retrospective case series aiming to evaluate both short and long-term outcomes of laparoscopic distal pancreatectomies with spleen preservation. Results: A total of 54 laparoscopic distal pancreatectomies were performed, in which 26 were laparoscopic distal pancreatectomies with spleen preservation by Kimura´s technique. Mean age was 47.9 years-old (21-75) where 61.5% were female. Mean BMI was 28.5 kg/m² (18-38.8). Mean diameter of lesion was 4.3 cm (1.8-7.5). Mean operative time was 144.1 min (90-200). Intraoperative bleeding was 119.2 ml (50-600). Conversion to laparotomy 3% (n=1). Postoperative morbidity was 11.5%. Postoperative mortality was null. Mean of hospital stay was 4.8 days (2-14). Mean time of follow-up period was 19.7 months (2-60). There was no neoplasm recurrence or mortality on evaluated period. There was no infectious complication. Conclusion: Laparoscopic distal pancreatectomy with spleen and splenic vessels preservation is feasible, safe, and effective procedure. This technique presented both low morbidity and null mortality on this sample. There were neither infectious complications nor neoplasm recurrence on long-term follow-up period.

RESUMO Racional: A pancreatectomia distal laparoscópica tem sido a abordagem de escolha para ressecção de tumores em pâncreas distal devido a muitas vantagens sobre a abordagem laparotômica. A técnica com preservação esplênica parece minimizar complicações infecciosas em longo prazo. Objetivo: Analisar os resultados das pancreatectomias distais laparoscópicas com preservação esplênica e dos vasos esplênicos. Método: Série de casos com 26 doentes operados para avaliar os resultados em curto e longo prazo. Resultados: Cinquenta e quatro pancreatectomias distais laparoscópicas foram realizadas nesse período, onde 26 foram pancreatectomias distais laparoscópicas com preservação esplênica pela técnica de Kimura. A média de idade foi 47,9 anos (21-75), onde 61,5% eram mulheres. A média do IMC foi 28,5 kg/m² (18-38,8). O diâmetro médio das lesões foi 4,3 cm (1,8-7,5). O tempo cirúrgico médio foi 144,1 min (90-200). A média de sangramento intra-operatório foi 119,2 ml (50-600). O índice de conversão foi 3% (n=1). A morbidade pós-operatória foi 11,5%, e a mortalidade nula. A média de internação hospitalar foi 4,8 dias (2-14). A média de seguimento foi 19,7 meses (2-60). Não houve recorrência de neoplasias e nem mortalidade durante esse período e também não houve complicações infecciosas em longo prazo. Conclusão: A pancreatectomia distal laparoscópica com preservação esplênica e dos vasos esplênicos é procedimento factível, seguro e eficaz no tratamento de neoplasias pancreáticas. Esta técnica apresentou baixa morbidade e mortalidade. Não houve complicações infecciosas e nem recidiva neoplásica em longo prazo.

Humans , Male , Female , Adult , Middle Aged , Aged , Young Adult , Pancreatectomy/methods , Spleen , Laparoscopy , Organ Sparing Treatments , Retrospective Studies
ABCD arq. bras. cir. dig ; 31(2): e1365, 2018. tab
Article in English | LILACS | ID: biblio-949218


ABSTRACT Background : The muscle-sparing thoracotomy (MST) has not yet been thoroughly studied and assessed in comparison to the traditional thoracotomy method in newborns. Aim : To compare the outcomes of MST and standard posterolateral thoracotomy (PLT) in newborns. Methods : Randomized, controlled, double-blind trial on 40 neonates with esophageal atresia, comparing the time of beginning a surgery until seeing the pleura, the duration of hospitalization in the neonatal intensive care unit, the time in ventilator, the time of returning the shoulder function, the time of returning the Moro reflex, and the mortality between the two techniques. Results : The data showed no differences between the two groups in basic information (weight, height, gender, numbers of prematurity neonates and caesarean). The results on the size of the scar in the MST group was significantly lower than in the PLT group. Also, the time of returning the shoulder function in MST group was earlier than in PLT group. There were no significant differences in the duration since the beginning the surgery to see the pleura, the time of being hospitalized in intensive unit, the time that the infant required ventilator, returning time of the Moro reflex in 1st and 3rd months after the operation, and the mortality rates between MST and PLT groups. Conclusion : It seems that the advantages of using MST over PLT procedure in neonates include the earlier shoulder function recovery and also superior cosmetic results.

RESUMO Racional : A técnica de toracotomia poupadora de músculo (MST) ainda não foi estudada e avaliada em relação ao método tradicional de toracotomia em recém-nascidos. Objetivo : Comparar os resultados da MST e toracotomia posterolateral padrão (PLT) em recém-nascidos. Métodos : Ensaio randomizado, controlado, duplamente cego em 40 neonatos com atresia esofágica, comparando o tempo de início da incisão até ver a pleura, a duração da hospitalização na unidade de terapia intensiva neonatal, o tempo em ventilador, o tempo da volta da função do ombro, tempo de retorno do reflexo Moro e mortalidade entre as duas técnicas. Resultados : Os dados não mostraram diferenças entre os dois grupos em informações básicas (peso, altura, gênero, número de neonatos de prematuridade e cesariana). Os resultados sobre o tamanho da cicatriz no grupo MST foram significativamente menores do que no grupo PLT. Além disso, o tempo de retorno da função do ombro no grupo MST foi mais precoce do que no grupo PLT. Não houve diferenças significativas na duração desde o início da operação até a pleura ser vista, o tempo de hospitalização em unidade intensiva, o tempo que a criança necessitou de ventilador, retorno do reflexo Moro nos 1º e 3º meses após a operação, e as taxas de mortalidade entre os grupos. Conclusão : As vantagens de usar o procedimento MST sobre PLT em neonatos incluem a recuperação da função do ombro e também resultados cosméticos superiores.

Humans , Male , Female , Infant, Newborn , Thoracotomy/methods , Esophageal Atresia/surgery , Organ Sparing Treatments , Pectoralis Muscles , Double-Blind Method , Superficial Back Muscles
National Journal of Andrology ; (12): 138-141, 2018.
Article in Chinese | WPRIM | ID: wpr-775206


Objective@#To explore the strategies of preserving urinary continence in transurethral plasmakinetic enucleation of the prostate (PKEP) for benign prostate hyperplasia (BPH).@*METHODS@#We treated 65 BPH patients by PKEP with preservation of urinary continence (UC-PKEP), which involved protection of the external urethral sphincter in the beginning of surgery, proper preservation of the anterior lobe of the prostate to protect the internal urethral sphincter in the middle, and preservation of the integrity of the bladder neck towards the end. We compared the postoperative status of urinary continence of the patients with that of the 54 BPH cases treated by complete plasmakinetic enucleation of the prostate (Com-PKEP).@*RESULTS@#All the operations were performed successfully with the urinary catheters removed at 5 days after surgery. In comparison with Com-PKEP, UC-PKEP achieved evidently lower incidence rates of urinary incontinence at 24 hours (31.49% vs 13.85%, P 0.05), and 3 months (3.70% vs 0%, P >0.05) after catheter removal. Compared with the baseline, the maximum urinary flow rate (Qmax) was significantly improved postoperatively in both the Com-PKEP ([7.43 ± 3.26] vs [20.58 ± 3.22] ml, P <0.05) and the UC-PKEP group ([8.04 ± 2.28] vs [20.66 ± 3.08] ml, P <0.05).@*CONCLUSIONS@#Transurethral PKEP is a safe and effective method for the management of BPH, during which the strategies of avoiding blunt or sharp damage to the external urethral sphincter in the beginning, properly preserving the anterior lobe of the prostate in the middle and preserving the integrity of the bladder neck towards the end may help to achieve rapid recovery of urinary continence.

Humans , Male , Organ Sparing Treatments , Methods , Postoperative Period , Prostatic Hyperplasia , General Surgery , Quality of Life , Transurethral Resection of Prostate , Methods , Treatment Outcome , Urethra , Urinary Bladder , Urinary Catheterization , Urinary Incontinence
Frontiers of Medicine ; (4): 509-517, 2018.
Article in English | WPRIM | ID: wpr-772737


This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P < 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.

Adolescent , Adult , Chemotherapy, Adjuvant , Child , China , Female , Humans , Infertility, Female , Neoplasm Staging , Organ Sparing Treatments , Ovarian Neoplasms , Drug Therapy , General Surgery , Pregnancy , Pregnancy Rate , Prognosis , Retrospective Studies , Survival Analysis , Young Adult
Rev. Assoc. Med. Bras. (1992) ; 63(12): 1082-1089, Dec. 2017. tab
Article in English | LILACS | ID: biblio-896324


Summary Introduction: Since the beginning of the 1990s, non-surgical radiochemotherapy treatment has become popular with the prospect of maintaining oncological results and preserving the organ in patients with advanced squamous cell carcinoma of the larynx and hypopharynx. However, subsequent studies demonstrated increased recurrence and mortality after the non-surgical treatment became popular. Objective: To compare the oncological results of surgical and non-surgical treatments of patients with larynx and hypopharynx cancer and to evaluate the variables associated with disease recurrence. Method: This is a retrospective cohort study of 134 patients undergoing surgical (total or partial laryngectomy) or non-surgical (isolated radiotherapy, chemotherapy or induction chemotherapy followed by radiotherapy and chemotherapy) treatment, with 62 patients in the surgical group and 72 in the non-surgical group. Results: Disease-free survival rates were higher in the surgical group (81.7% vs. 62.2%; p=0.028), especially in III/IV stages (p=0.018), locally advanced tumors T3 and T4a (p=0.021) and N0/N1 cases (p=0.005). The presence of cervical lymph nodes, especially N2/N3, was considered a risk factor for disease recurrence in both groups (HR=11.82; 95CI 3.42-40.88; p<0.0001). Patients not undergoing surgical treatment were 3.8 times more likely to develop recurrence (HR=3.76; 95CI 1.27-11.14; p=0.039). Conclusion: Patients with larynx or hypopharynx cancer non-surgically treated had a poorer disease-free survival, especially in cases with locally advanced tumors (T3 and T4a) and in which the neck was only slightly affected (N0/N1).

Resumo Introdução: A partir de estudos do início dos anos 1990, popularizou-se o tratamento não cirúrgico com radioquimioterapia, com a perspectiva de manutenção do resultado oncológico e preservação do órgão em pacientes com carcinoma espinocelular avançado de laringe e hipofaringe. Entretanto, estudos posteriores demonstraram aumento da recorrência e da mortalidade com a difusão do tratamento não cirúrgico. Objetivo: Comparar o resultado oncológico dos tratamentos cirúrgico e não cirúrgico de pacientes com câncer de laringe e hipofaringe e avaliar as variáveis associadas à recidiva de doença. Método: Estudo de coorte retrospectiva de pacientes submetidos ao tratamento cirúrgico (laringectomia total ou parcial) e não cirúrgico (radioterapia isolada, radioterapia concomitante a quimioterapia ou quimioterapia de indução seguida de radioterapia e quimioterapia) de 134 pacientes, sendo 62 no grupo cirúrgico e 72 no não cirúrgico. Resultados: As taxas de sobrevivência livre de doença foram maiores no grupo cirúrgico (81,7% vs. 62,2%; p=0,028), principalmente em estádios III/IV (p=0,018), tumores localmente avançados T3 e T4a (p=0,021) e casos N0/N1 (p=0,005). A presença de linfonodos cervicais, principalmente N2/N3, foi considerada fator de risco para recidiva de doença nos dois grupos (HR=11,82; IC95% 3,42-40,88; p<0,0001). Pacientes não submetidos ao tratamento cirúrgico apresentaram 3,8 vezes mais chance de desenvolvimento de recidiva (HR=3,76; IC95% 1,27-11,14; p=0,017). Conclusão: Pacientes com câncer de laringe ou hipofaringe tratados de forma não cirúrgica tiveram menor sobrevivência livre de doença, especialmente nos tumores localmente avançados (T3 e T4a) e com pescoço pouco comprometido (N0/N1).

Humans , Male , Female , Aged , Carcinoma, Squamous Cell/surgery , Hypopharyngeal Neoplasms/surgery , Laryngeal Neoplasms/surgery , Organ Sparing Treatments , Time Factors , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/radiotherapy , Hypopharyngeal Neoplasms/mortality , Hypopharyngeal Neoplasms/pathology , Hypopharyngeal Neoplasms/radiotherapy , Laryngeal Neoplasms/mortality , Laryngeal Neoplasms/pathology , Laryngeal Neoplasms/radiotherapy , Retrospective Studies , Disease-Free Survival , Hypopharynx/pathology , Laryngectomy , Larynx/pathology , Middle Aged , Neoplasm Staging
Int. braz. j. urol ; 43(6): 1043-1051, Nov.-Dec. 2017. tab, graf
Article in English | LILACS | ID: biblio-892926


ABSTRACT Purpose: To present modified RRP using the same method as RALP and compare its surgical outcomes with RALP. Materials and Methods: Demographics, perioperative and functional outcomes of the 322 patients that underwent RRP (N=99) or RALP (N=223) at our institution from January 2011 through June 2013 were evaluated retrospectively. Postoperative incontinence and erectile dysfunction are involved functional outcomes. During the modified procedure, the bladder neck was dissected first as for RALP. After dissection of vas deference and seminal vesicle, the prostate was dissected in an antegrade fashion with bilateral nerve saving. Finally, the urethra was cut at the prostate apex. After a Rocco suture was applied, and then urethrovesical anastomosis was performed with continuous suture as for RALP. Results: Perioperative characteristics and complication rates were similar in the RRP and RALP groups except for mean estimated blood loss (p<0.001) and operative time (p<0.001). Incontinence rates at 3 and 12 months after RRP decreased from 67.6% to 10.1 and after RALP decreased from 53.4% to 5.4%. Positive surgical margin rates were non-significantly different in the RRP and RALP groups (30.3% and 37.2%, respectively). Overall postoperative potency rate at 12 months was not significant different in RRP and RALP groups (34.3% and 43.0%). Conclusions: RRP reproducing RALP was found to have surgical outcomes comparable to RALP. This technique might be adopted by experienced urologic surgeons as a standard procedure.

Humans , Male , Aged , Prostate/innervation , Prostatectomy/methods , Prostatic Neoplasms/surgery , Organ Sparing Treatments/methods , Robotic Surgical Procedures/adverse effects , Postoperative Complications , Prostate/surgery , Prostatectomy/adverse effects , Time Factors , Anastomosis, Surgical , Retrospective Studies , Treatment Outcome , Length of Stay
Int. braz. j. urol ; 43(6): 1033-1042, Nov.-Dec. 2017. tab, graf
Article in English | LILACS | ID: biblio-892923


ABSTRACT Introduction: A rectum balloon implant (RBI) is a new device to spare rectal structures during prostate cancer radiotherapy. The theoretical advantages of a RBI are to reduce the high radiation dose to the anterior rectum wall, the possibility of a post-implant correction, and their predetermined shape with consequent predictable position. Objective: To describe, step-by-step, our mini-invasive technique for hands-free transperineal implantation of a RBI before start of radiotherapy treatment. Materials and Methods: We provide step-by-step instructions for optimization of the transperineal implantation procedure performed by urologists and/or radiation oncologists experienced with prostate brachytherapy and the use of the real-time bi-plane transrectal ultrasonography (TRUS) probe. A RBI was performed in 15 patients with localised prostate cancer. Perioperative side-effects were reported. Results: We provide 'tips and tricks' for optimizing the procedure and proper positioning of the RBI. Please watch the animation, see video in The side-effects included mild discomfort to slight pain at the perineal region in 8 out of 15 patients. Seven patients (47%) had no complaints at all. Two patients developed redness of the skin, where prompt antibiotic regimen was started with no further sequelae. One patient revealed a temporary urine retention, which resolved in a few hours following conservative treatment. Further no perioperative complications occurred. Conclusion: This paper describes in detail the implantation procedure for an RBI. It is a feasible, safe and very well-tolerated procedure.

Humans , Male , Prostatic Neoplasms/radiotherapy , Radiation Injuries/prevention & control , Rectum/radiation effects , Absorbable Implants , Organ Sparing Treatments/instrumentation , Radiotherapy Planning, Computer-Assisted , Feasibility Studies
Rev. cuba. cir ; 56(4): 0-0, oct.-dic. 2017. tab
Article in Spanish | LILACS | ID: biblio-900996


Introducción: en la actualidad existe consenso en la importancia de categorizar a los pacientes por grupo de riesgo a la hora de determinar la selección del tratamiento quirúrgico adecuado en pacientes con carcinoma bien diferenciado. Objetivo: describir los resultados de la cirugía conservadora y la tiroidectomía total realizadas a los pacientes con cáncer tiroideo bien diferenciado. Método: se realizó una investigación descriptiva de corte longitudinal desde 1995 hasta 2016, en el servicio de cirugía general del Hospital Clínico Quirúrgico Hermanos Ameijeiras. Las principales variables fueron demográficas, relativas al tumor, tipo de intervención quirúrgica y de resultados. Resultados: se estudiaron 183 pacientes. La tiroidectomía total fue la intervención quirúrgica más realizada (79,2 por ciento). El grupo etario que predominó fue el de 41 a 50 años (30,6 por ciento). En los grupos de edades de 19 a 40 años se realizaron más técnicas conservadoras, y en mayores de 40 años fue más frecuente la tiroidectomía total. El sexo predominante fue el femenino (82,5 por ciento). El tamaño del tumor que predominó fue de 1cm a 2,9 cm. En el grupo de bajo riesgo se realizaron 38 técnicas conservadoras y 62 tiroidectomías totales. La cirugía conservadora no presentó complicaciones, recurrencia, ni mortalidad. Mientras que, en la tiroidectomía total, 3,3 por ciento presentó disfonía transitoria, hipoparatiroidismo transitorio en 2,2 por ciento y permanente 0,5 por ciento. La mortalidad fue de 2,2 por ciento y 3,8 por ciento presentó recurrencia local. Conclusiones: la cirugía conservadora no presentó complicaciones, recurrencia, ni mortalidad, mientras que la tiroidectomía total si la tuvo(AU)

Introduction: Currently there is agreement regarding the importance of categorizing patients by risk groups in order to choose the most accurate treatment for well-differentiated thyroid cancer. Objective: To describe the results of conservative surgery as well as of total thyroidectomy performed on patients with well-differentiated thyroid cancer. Methods: A descriptive research of longitudinal cohort was performed between 1995 and 2016 at the General Surgery Service of Hermanos Ameijeiras Hospital. The main variables used were demographic, related with tumor, surgery type and type of results. Results: 183 patients were studied. The most used surgery type was the total thyroidectomy (79.2 percent). Individuals aged 41-50 years were predominant (30.6 percent). Conservative technics were more frequently performed in the group of patients aged 19-40. For patients older than 40 years, the total thyroidectomy was the most frequent. The female sex was the biggest group (82.5 percent). The predominant tumor size was in the range from 1 to 2.9 cm. In the low-risk group, 30 conservative surgeries and 62 total thyroidectomies were performed. Conservative surgeries had no complications, relapse or mortality. Regarding total thyroidectomy, 3.3 percent of the patients suffered transitory dysphonia, 2.2 percent presented transitory hypoparathyroidism, and 0.5 percent presented permanent hypoparathyroidism. Local relapse after total thyroidectomy was suffered by 3.8 percent of patients and mortality was 2.2 percent. Conclusions: The conservative surgery had no complications, relapse or mortality, while total thyroidectomy did present them(AU)

Humans , Female , Adult , Middle Aged , Organ Sparing Treatments/statistics & numerical data , Prognosis , Thyroid Neoplasms/pathology , Thyroidectomy/methods , Risk Groups