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1.
Rev. Ciênc. Plur ; 8(1): e24820, 2022. tab, graf
Article in Portuguese | LILACS, BBO | ID: biblio-1348511

ABSTRACT

Introdução:O carcinoma de células escamosas de cavidade oral e orofaringe é uma neoplasia epitelial maligna comum, respondendo pela maioria dos casos de tumores de cabeça e pescoço. Ele está relacionado a hábitos comportamentais, como tabagismo e etilismo de longa duração, e à infecção pelo Papilomavírus humano. Objetivos:Esse estudo objetivou descrever o perfil epidemiológico dos pacientes diagnosticados com essa neoplasia na Liga Mossoroense de Estudos e Combate ao Câncer. Metodologia: Foi realizado um estudo observacional com delineamento transversal a partir de dados presentes nos prontuários clínicos e laudos anatomopatológicos e no Sistema de Informações sobre Mortalidade no período entre 2006 a 2018. Os dados foram analisados a partir do Software R, utilizandoo teste de Wilcoxon-Mann-Whitney para as análises inferenciais e o método de Kaplan-Meier para análise da sobrevida. Resultados:225 prontuários foram analisados, sendo 70,22% de homens, 65,33% na faixa etária entre 46-70 anos e cor branca (51,57%). Destes, 25,78% eram tabagistas e 39,11% tabagistas e etilistas. O principal tratamento identificado foi a associação de cirurgia, quimioterapia e radioterapia. Observou-se que 49,10% dos óbitos foram em decorrência dessa neoplasia. O principal estádio patológico encontrado foi o quatro A (34,22%). Foi identificada maior sobrevida nos pacientes acima de 70 anos, cujo tratamento foi exclusivamente cirúrgico. Menor sobrevida foi identificada em indivíduos que tinham associação de hábitos (etilismo e tabagismo). Conclusões:Nossos resultados sugerem que a evolução à óbito foi o principal desfecho clínico e, isso pode estar relacionado aos hábitos comportamentais que influenciam diretamente o curso e prognóstico da doença. Ademais, destaca-se a importância do diagnóstico precoce a fim de reduzir óbitos e melhorar a qualidade de vida dos indivíduos, assim como a necessidade de implementar políticas educativas sobre os principais fatores de risco associados ao desenvolvimento dessa neoplasia (AU).


Introduction: Squamous cell carcinoma of the oral cavity and oropharynx is a common malignant epithelial neoplasm, accounting for most cases of head and neck tumors. It is related to behavioral habits, such as long-standing smoking and alcoholism, as well as to the human Papillomavirus infection. Objectives: This study aimed at describing the epidemiological profile of the patients diagnosed with this neoplasm in the Mossoró League for Studying and Combating Cancer. Methodology:An observational study with a cross-sectional design was carried out based on data present in the medical records and anatomopathological reports and in the Mortality Information System during the 2006-2018 period. The data were analyzed using the R Software, resorting to the Wilcoxon-Mann-Whitneytest for the inferential analyses and to the Kaplan-Meier method for survival analysis. Results: 225 medical records were analyzed: 70.22% belonging to men, 65.33% aged between 46 and 70 years old and white-skinned (51.57%). Of these, 25.78% were smokers and 39.11% were smokers and alcoholics. The main treatment identified was the association of surgery, chemotherapy and radiotherapy. It was observed that 49.10% of the deaths were due to this neoplasm. The main pathological stage found wasfour A(34.22%).Longer survival was identified in patients over 70 years of age, whose treatment was exclusively surgical. Shorter survival was identified in individuals who had associated habits (alcoholism and smoking). Conclusions:Our results suggest that evolution to death was the main clinical outcome; this can be related to the behavioral habits that exert a direct influence on the course and prognosis of the disease. Furthermore, the importance of early diagnosis is highlighted in order to reduce the number of deaths and improve the individuals' quality of life, as well as the need to implement educational policies on the main risk factors associated with the development of this neoplasm (AU).


Introducción: El carcinoma de células escamosas de la cavidad oral y la orofaringe es una neoplasia epitelial maligna común, que representa la mayoría de los casos de tumores de cabeza y cuello. Se relaciona con hábitos de comportamiento, como el tabaquismo y el alcoholismo, y la infección por el virus papiloma humano. Objetivos:Este estudio tuvo como objetivo describir el perfil epidemiológico de los pacientes diagnosticados con esta neoplasiaen la Liga Mossoroense de Estudios y Combate al Cáncer. Metodología: Se realizó un estudio observacional, transversal a partir de los datos presentes en las historias clínicas e informes patológicos y en el Sistema de Información de Mortalidad en el período 2006-2018. Los datos se analizaron mediante el Software R, con utilización de la Prueba de Wilcoxon-Mann-Whitney para análisis inferencial y el método de Kaplan-Meier para análisis de supervivencia. Resultados:Se analizaron 225 historias clínicas, 70,22% en hombres, 65,33% con edades entre 46-70 años y blancos (51,57%). De estos, 25,78% eran fumadores y 39,11% eran fumadores y alcohólicos. El principal tratamiento identificado fue la asociación de cirugía, quimioterapia y radioterapia. 49,10% de las muertes se debieron a esta neoplasia. El principal estadio patológico encontrado fue cuatro A (34,22%). Se identificó mayor sobrevida en pacientes mayores de 70 años, cuyo tratamiento fue exclusivamente quirúrgico. Se identificó una menor sobrevida en personas que tenían hábitos asociados. Conclusiones:Nuestros resultados sugieren que la evolución hacia la muerte fue el principal resultado clínico y esto puede estar relacionado con hábitos de comportamiento que influyen directamente en el curso y pronóstico de la enfermedad. Además, se destaca la importancia del diagnóstico precoz para reducir las muertes y mejorar la calidad de vida, así como la necesidad de implementar políticas educativas sobre los principales factores de riesgo asociados al desarrollo de esta neoplasia (AU).


Subject(s)
Humans , Health Profile , Brazil/epidemiology , Mouth Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Oropharyngeal Neoplasms/pathology , Head and Neck Neoplasms/pathology , Tobacco Use Disorder , Survival Analysis , Epidemiology , Cross-Sectional Studies , Statistics, Nonparametric , Papillomavirus Infections , Research Report , Smokers
2.
Rev. Ciênc. Plur ; 8(1): e24554, 2022. tab
Article in Portuguese | LILACS, BBO | ID: biblio-1348513

ABSTRACT

Introdução:O câncer de cabeça e pescoço é um conjunto de neoplasias que atingem o trato aero digestivo superior. Essas neoplasias apresentam sintomatologia variada, que depende da localização do tumor, gravidade e tempo de ocorrência. Objetivo:Avaliar o nível de conhecimento da população, usuária da atenção básica, acerca da prevenção e tratamento dos Cânceres de Cabeça e Pescoço.Metodologia:Trata-se de um estudo de campo transversal descritivo, em que se coletou informações acerca do conhecimento sobre cânceres de cabeça e pescoço, informações sociodemográficas, histórico familiar, características clínicas e de tratamentos. A coleta foi realizada em julho de 2019, em três Estratégias de Saúde da Família da cidade de Piripiri,Piauí. A pesquisa foi submetida e aprovadapelo Comitê de Ética em Pesquisa com o Parecer nº 3.221.522.Resultadose discussão:A maioria dos entrevistados foram mulheres solteiras com idade média de 44,4 anos e de baixa renda. Dentre os questionamentos realizados, grande parte não soube responderquestões sobre conhecimentos gerais a respeito dessas enfermidades. Outro fator importante é a baixa procura por serviços de saúde. Conclusões:Observou-se que os entrevistados apresentam desinformação a respeito da prevenção e tratamento desse grupo de cânceres, sendo necessário o fortalecimento de ações de educação popular em saúde (AU).


Introduction:Head and neck cancer is a group of neoplasms that affect the upper aerodigestive tract. These neoplasms have varied symptoms, depending on the location of the tumor, severity and time of occurrence.Objective:To assess the level of knowledge of the population, users of primary care, about the prevention and treatment of Head and Neck Cancer. Methodology:This is a descriptive cross-sectional study, in which information about knowledge about head and neck cancers, sociodemographic information, family history, clinical and treatment characteristics was collected. The collection was carried out in July 2019, in three Family Health Strategies in the city of Piripiri, Piauí. The research was submitted and approved by theResearch Ethics Committee with Opinion No. 3,221,522. Resultsand discussion:Most of the interviewees were single women with an average age of 44.4 years and low income. Among the questions asked, most of them did not know how to answer questions about general knowledge about these diseases. Another important factor is the low demand for health services. Conclusions:It was observed that the interviewees have misinformation regarding the prevention and treatment of this group of cancers, and it is necessary to strengthen popular health education actions (AU).


Introducción:El cáncer de cabeza y cuello es un grupo de neoplasias que afectan el tracto aerodigestivo superior. Estas neoplasias tienen síntomas variados, que dependen de la ubicación del tumor, la gravedad y el momento de aparición. Objetivo:Evaluar el nivel de conocimiento de la población, usuarios de la atención primaria de salud, sobre la prevención y el tratamiento del Cáncer de Cabeza y Cuello. Metodología:Se trata de un estudio descriptivo transversal, en el que se recopiló información sobre conocimientos sobre cánceres de cabeza y cuello, información sociodemográfica, antecedentes familiares, características clínicas y de tratamiento. La recolección se realizó en julio de 2019, en tres Estrategias de Salud de la Familia en la ciudad de Piripiri, Piauí. La investigación fue sometida y aprobada por el Comité de Ética en Investigación con Opinión No. 3.221.522. Resultados y discusión:La mayoría de los encuestados eran mujeres solteras con una edad promedio de 44,4 años y bajos ingresos. Entre las preguntas formuladas, la mayoría de ellos no sabía cómo responder preguntas sobre conocimientos generales sobre estas enfermedades. Otro factor importante es la baja demanda de servicios de salud. Conclusiones:Se observó que los entrevistados tienen desinformación sobre la prevención y tratamiento de este grupo de cánceres, y es necesario fortalecer las acciones de educación popular en salud (AU).


Subject(s)
Humans , Male , Female , Adolescent , Adult , Primary Health Care , Primary Prevention , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Head and Neck Neoplasms/pathology , Brazil/epidemiology , Health Education , Epidemiology, Descriptive , Cross-Sectional Studies/methods , Surveys and Questionnaires , Disease Prevention
3.
Rev. Ciênc. Plur ; 7(2): 107-118, maio 2021. tab, graf
Article in Portuguese | LILACS, BBO | ID: biblio-1282976

ABSTRACT

Introdução:Os tumores de cabeça e pescoço têm expressiva incidência e mortalidade, assim comoalta letalidade, e constituem um relevante problema de saúde pública, particularmente nos países em desenvolvimento. Dentre as neoplasias malignas diagnosticadas no mundo, aproximadamente 10% estão localizadas na boca, sendo esse o sexto tipo de câncer mais incidente. Objetivo:Avaliar o perfil epidemiológico de pacientes diagnosticados com câncer de boca e faringe da Liga Mossoroense de Estudos e Combate ao Câncer do município de Mossoró, Rio Grande do Norte,Brasil,entre janeiro 2013 e junho de 2018.Metodologia:Estudo transversal, fundamentado na análise retrospectiva e descritiva de prontuários médicos.Resultados:Dos221 prontuáriosanalisados, a cor branca (56,6%) e o gênero masculino (70,6%) foram os mais prevalentes, com média de idade entre 55 e65 anos. A maioria (61,9%) apresentava ensino fundamental incompleto, sendo residentes de área urbana (59,6%) com histórico de uso de tabaco (64,6%) e/ou bebidas alcoólicas (53,9%). Osítio mais prevalente de câncer em boca foi a base da língua (12,7%).Conclusões:Conhecer o perfil dos pacientes com câncer de boca e orofaringe é um importante passo para melhor traçar e direcionar ações de saúde pública visando tanto àprevenção quanto o diagnóstico precoce (AU).


Introduction:Head and neck tumors have a significant incidence and mortality, as well as high lethality, and are a relevant public health problem, particularly in developing countries. Among the malignant neoplasms diagnosed in the world, approximately 10% are located in the mouth, this being the sixth most frequent type of cancer. Objective:To evaluate the epidemiological profile of patients diagnosed with oral and pharyngeal cancer of the Mossoroense League of Studies and Cancer Fighting in the municipality of Mossoró, Rio Grande do Norte, Brazil,between January 2013 and June 2018.Methodology:Cross-sectional study, based on retrospective and descriptive analysis of medical records.Results:Of the 221 records analyzed, white (56.6%) and male (70.6%) were the most prevalent, with a mean age between 55 and 65 years. Most (61.9%) had incomplete primary education, being residents of an urban area (59.6%) with a history of tobacco use (64.6%) and / or alcoholic beverages (53.9%).The most prevalent site of cancer in the mouth was the base of the tongue (12.7%). Conclusions:Knowing the profile of patients with oral and oropharyngeal cancer is an important step to better outline and direct public health actions aimed at both prevention and early diagnosis (AU).


Introducción: Los tumores de cabeza y cuello tienen una expresiva incidencia y mortalidad, así como alta letalidad, y constituyen un relevante problema de salud pública, especialmente en los países en desarrollo. Entre las neoplasias malignas diagnosticadas en el mundo,aproximadamente el 10% están localizadas en la boca, siendo este el sexto tipo de cáncer más común.Objetivo: Evaluar el perfil epidemiológico de pacientes diagnosticados con cáncer de boca y faringe de la Liga Mossoroense de Estudos e Combate ao Câncer del municipio de Mossoró, Rio Grande do Norte, Brasil,entre enero de 2013 y junio de 2018.Metodologia: Estudio transversal, basado en el análisis retrospectivo y descriptivo de los registros médicos.Resultados: De los 221 registros analizados, blancos (56,6%) y varones (70,6%) han sido los más prevalentes, con una media de edad entre 55 y 65 años. La mayoría (61,9%) presentaba educación primaria incompleta, siendo residentes de área urbana (59,6%) con antecedentes de uso de tabaco (64,6%) y/o bebidas alcohólicas (53,9%). El sitio más prevalente de cáncer en boca fuelabase de la lengua (12,7%). Conclusiones: Conocer el perfil de los pacientes con cáncer de boca y orofaringe es un importante paso para mejor delinear y dirigir acciones de salud pública objetivando tanto la prevención como el diagnóstico precoz (AU).


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Health Profile , Brazil/epidemiology , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Early Diagnosis , Medical Records , Cross-Sectional Studies/methods , Data Interpretation, Statistical , Qualitative Research
4.
Einstein (Säo Paulo) ; 18: eRC5409, 2020. graf
Article in English | LILACS | ID: biblio-1133733

ABSTRACT

ABSTRACT Percutaneous endoscopic gastrostomy is used to provide enteral nutritional support for patients with obstructive oropharyngeal or esophageal neoplasms. The placement of the catheter is considered safe, with few complications. Despite this, a specific complication that is considered rare, has been increasingly described in the literature, i.e., metastasis of head and neck cancer in the gastrostomy stoma. In this report, we described a case of metastasis of squamous cell carcinoma of the larynx in the gastrostomy site, and discussed the possible etiologies and alternatives, seeking to reduce the incidence of this complication.


RESUMO A gastrostomia endoscópica percutânea é utilizada para oferecer suporte nutricional enteral para pacientes com neoplasias obstrutivas de orofaringe ou esôfago. A colocação da sonda é considerada segura, com poucas complicações. Apesar disso, uma complicação em particular, considerada rara, está sendo cada vez mais descrita na literatura: a metástase de neoplasia de cabeça e pescoço para o estoma da gastrostomia. Neste relato, descrevemos um caso de metástase de carcinoma espinocelular de laringe para o sítio da gastrostomia, e discutimos as possíveis etiologias e alternativas, buscando diminuir a incidência desta complicação.


Subject(s)
Humans , Male , Stomach Neoplasms/secondary , Esophageal Neoplasms/pathology , Gastrostomy/adverse effects , Carcinoma, Squamous Cell/secondary , Oropharyngeal Neoplasms/pathology , Laryngeal Neoplasms/pathology , Head and Neck Neoplasms/pathology , Stomach Neoplasms/surgery , Carcinoma, Squamous Cell/therapy , Carcinoma, Squamous Cell/diagnostic imaging , Enteral Nutrition/adverse effects , Head and Neck Neoplasms/therapy , Middle Aged , Neoplasm Metastasis
5.
J. appl. oral sci ; 28: e20190166, 2020. tab
Article in English | LILACS, BBO, BNUY | ID: biblio-1056589

ABSTRACT

Abstract Oral and oropharyngeal cancer is considered a public health problem in several countries due to its high incidence and mortality rate. Objective: This study aimed to analyze oral and oropharyngeal cancer mortality in Uruguay from 1997 to 2014 by age, sex and country region. Methodology: A time series ecological study using secondary data was performed. Data on mortality due to oral and oropharyngeal cancers were obtained from the Vital Statistics Department of Uruguay's Ministry of Public Health. Results: The cumulative mortality rate due to oral and oropharyngeal cancer over the study period was of 19.26/100,000 persons in women and 83.61/100.000 in men, with a mean annual rate of 1.75/100,000 in women and 7.60/100,000 in men. Mortality rate from both sites during the study period was 4.34 times higher in men than in women. Malignant neoplasms of other parts of the tongue and base of tongue showed the highest mortality rate. The means of the annual coefficients of deaths were higher for the age groups between 50 and 69 years. Higher mortality rates of oral and oropharyngeal cancer were observed in Artigas (4.63) and Cerro Largo (3.75). Conclusions: Our study described a high mortality rate for oral and oropharyngeal cancer in Uruguay from 1997 to 2014. According to the country's health department, men, tongue cancer, and oral cavity had higher mortality rates, with some variation. Prevention strategies with control of risk factors and early diagnosis are necessary to improve survival in the Uruguayan population.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Oropharyngeal Neoplasms/mortality , Squamous Cell Carcinoma of Head and Neck/mortality , Time Factors , Uruguay/epidemiology , Tongue Neoplasms/mortality , Tongue Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Incidence , Risk Factors , Sex Distribution , Age Distribution , Squamous Cell Carcinoma of Head and Neck/pathology
6.
Clinics ; 75: e1507, 2020. tab, graf
Article in English | LILACS | ID: biblio-1101092

ABSTRACT

OBJECTIVE: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS: The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models. RESULTS: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year. CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Mouth Neoplasms/mortality , Carcinoma, Squamous Cell/mortality , Oropharyngeal Neoplasms/mortality , Prognosis , Brazil/epidemiology , Mouth Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Oropharyngeal Neoplasms/pathology , Proportional Hazards Models , Survival Analysis , Retrospective Studies , Kaplan-Meier Estimate , Neoplasm Staging
7.
J. oral res. (Impresa) ; 7(1): 20-23, ene. 22, 2018. tab
Article in English | LILACS | ID: biblio-1119248

ABSTRACT

To determine mortality rates for oropharyngeal cancer according to the Human Development Index (HDI) per district in the Metropolitan Region (RM), Santiago, Chile, between 2002 and 2014. Materials and Methods: an ecological study was carried out. The sample corresponded to individuals over 45 years, from the Metropolitan Region, with oropharyngeal cancer as cause of death, as registered in the Chilean National Institute of Statistics (INE). The HDI was classified into three categories: "medium" (8 districts), "high" (18 districts) and "very high" (25 districts). The crude and adjusted mortality rates were calculated for each year and period. Results: the oropharyngeal cancer adjusted mortality rate for the chosen period was 3.98 deaths per 100,000 inhabitants. The specific mortality rate from oropharyngeal cancer in the "medium" HDI category was 4.01; in the "high" DHI category, 4.42; and in the "very high" HDI category, 3.79. Conclusion: mortality from oropharyngeal cancer was higher in the "medium" HDI category between 2002 and 2014.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Oropharyngeal Neoplasms/mortality , Oropharyngeal Neoplasms/pathology , Chile/epidemiology , Incidence , Sex Distribution , Age Distribution , Ecological Studies
9.
Odonto (Säo Bernardo do Campo) ; 24(48): 55-60, jul.-dez. 2016. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-909484

ABSTRACT

Racional ­ Tumor maligno pode comprometer a cavidade oral e promover alterações sistêmicas muito graves que podem levar à morte. Objetivo ­ Descrever como um tumor pode atingir a cavidade oral de um indivíduo de forma a modificar sua qualidade de vida até culminar com seu óbito. Material e Métodos ­ Adulto do sexo masculino, desempregado, usuário de drogas como: maconha, cocaína, crack, álcool e tabaco, apresentou, durante a fase aguda, pequeno nódulo em região de hemiarco superior esquerdo, na altura dos pré-molares. No exame físico, apresentava dor à palpação com pequeno nódulo não flutuante, localizada em região cervical esquerda. A biópsia evidenciou células tumorais malignas. Resultados ­ Observado progressão rápida, com debilidade adstrita do paciente; resultando em óbito. Conclusão ­ Conclui-se com base no caso acima relatado e tendo a literatura como aliada, que os tumores avançados de orofaringe podem progredir de forma rápida e devastadora, sendo sua taxa de sobrevida muito baixa, além de causar ao paciente constrangimento sócio emocional.(AU)


Subject(s)
Humans , Male , Middle Aged , Carcinoma, Squamous Cell/pathology , Mouth Diseases/pathology , Oropharyngeal Neoplasms/pathology , Biopsy , Disease Progression , Fatal Outcome , Risk Factors , Substance-Related Disorders/complications
10.
Natal; s.n; fev. 2016. 105 p. ilus, tab, graf. (BR).
Thesis in Portuguese | LILACS, BBO | ID: biblio-867988

ABSTRACT

Falhas nos genes responsáveis por reparos no DNA podem influenciar no surgimento de câncer ou afetar a resposta aos tratamentos. Estudos têm demonstrado que a variação na capacidade de reparo do DNA pode ser resultado de polimorfismos funcionais nestes genes, e alguns destes experimentos sugerem que a presença de polimorfismos de nucleotídeos simples (SNPs), em genes de reparo, está relacionada ao desenvolvimento e resposta ao tratamento de vários cânceres, incluindo o Carcinoma Epidermoide Oral (CEO) e o Carcinoma Epidermoide de Orofaringe (CEOR). Nesta pesquisa avaliou-se a frequência de três SNPs em dois genes de reparo do DNA RAD51 172G>T (c.-61 G>T, rs1801321), RAD51 135G>C (c.-98 G>C, rs1801320) e XRCC3 T241M (c. 722 C>T, rs861539) em indivíduos saudáveis (n=130) e indivíduos com CEO e CEOR (n=126) e investigou-se possíveis relações de tais achados com os desfechos clínicos: resposta tumoral ao tratamento com radioterapia e quimioterapia, recidiva, e sobrevida global. Constatou-se frequência alélica e genotípica em equilíbrio. A presença dos SNPs analisados não revelou ser um fator de risco para o desenvolvimento de CEO ou CEOR; contudo, quando associado ao hábito de fumar ou beber, aumentou o risco de desenvolver o câncer de três a cento e cinquenta vezes (p<000,1). A resposta tumoral ao tratamento de radioterapia e quimioterapia foi semelhante nos pacientes com ou sem SNPs. Nenhum polimorfismo demonstrou significância estatística em relação à sobrevida livre de recidiva ou sobrevida global. Os genótipos AA e AC do SNP rs861539 no gene XRCC3, os genótipos CC e CG do SNP rs1801320 e GG e GT do SNP 1801321 no gene RAD51, aumentam o risco do desenvolvimento de carcinoma epidermoide oral e de orofaringe, quando associados ao hábito de beber ou fumar. Os polimorfismos estudados nos genes XRCC3 e RAD51 não estão associados à resposta à radioterapia, sobrevida livre de recidiva ou sobrevida global


Faults in the genes responsible for repairs to the DNA can influence the onset of cancer or affect the response to treatment. This research evaluated the frequency of three single nucleotide polymorphisms (SNPs) in two repair genes DNA RAD51 172g> T (rs1801321), RAD51 135G> C (rs1801320) and XRCC3 T241M (rs861539) in individuals without cancer (n = 130) and patients with oral squamous cell carcinoma (OSC) and carcinoma oropharyngeal squamous (ORSC) (n = 126) and investigated possible relationships of these findings with clinical and pathological data and clinical outcomes: tumor response to radiotherapy and chemotherapy, disease-free survival, and overall survival. It was found that the allele and genotype frequencies were in equilibrium Hard-Weinberg equilibrium. The presence of at least one polymorphic allele in XRCC3 (rs861539) gene is associated with histological grade (WHO) higher (p = 0.007). We observed a higher recurrence rate trend (p = 0.08) and more advanced stage (p = 0.08) in the group that had at least one polymorphic allele of RAD51 gene (rs1801321). The presence of the analyzed SNPs not proved to be a risk factor for the development of CEO or CEOR; however, when combined with smoking or drinking, increased the risk of developing cancer from three to one hundred and fifty times. The tumor response to radiotherapy and chemotherapy was similar in patients with and without SNPs. No polymorphism showed statistical significance in relation to recurrence-free survival or overall survival. We conclude that the presence of at least one polymorphic allele of the SNPs rs861539 in XRCC3 gene, rs1801320 and rs1801321 in the RAD51 gene increase the risk of development of OSC and ORSC, when associated with the habit of drinking or smoking. Polymorphisms studied in XRCC3 and RAD51 genes are not associated with response to radiation therapy, relapse-free survival or overall survival


Subject(s)
Humans , Male , Female , Carcinoma, Squamous Cell/surgery , Carcinoma, Squamous Cell/radiotherapy , DNA Repair , Oropharyngeal Neoplasms/pathology , Prognosis , Polymorphism, Single Nucleotide/immunology , Brazil , Chi-Square Distribution , Logistic Models , Longitudinal Studies , Survival Analysis
12.
Rev. chil. cir ; 63(3): 250-256, jun. 2011. tab
Article in Spanish | LILACS | ID: lil-597512

ABSTRACT

Introduction: Oral cancer is a common disease in many parts of the world, in Chile only accounts for 1.6 percent of all cancers. The majority is squamous cell carcinoma with important clinical, epidemiological and pathological differences between lip, oral and orofaringeal locations. Objective: To analyze clinical and pathological characteristics of oral and oropharingeal squamous cell carcinoma in Temuco, Chile. Materials and Methods: A descriptive, retrospective study of all diagnosed cases in 15 years (1994 and 2008). The patients were analyzed according to gender, age; and the tumors were classified based on anatomic location, size, macroscopical findings and degree of differentiation. Results: We found 93 carcinomas, with male to female ratio of 5:1, average age 67 years. Patients under 50 years accounted for only 8 percent of cases. The most common sites were lower lip, tongue and gingiva, with an average size of 28 mm, which increased towards orofarinx and more than half were moderately differentiated. Conclusions: In our region, this carcinoma most often affects the seventh decade of life and male population and has similar characteristics to those in other countries which is predominantly. The size at diagnosis is significant. The detection of some differences in the group with mapuche surnames warrants a study with a larger number of cases.


Introducción: El cáncer oral es una enfermedad frecuente en muchas partes del mundo, en Chile corresponde al 1,6 por ciento del total de cánceres. La gran mayoría corresponde a carcinoma epidermoide, con importantes diferencias clínicas, epidemiológicas y patológicas entre las localizaciones labial, intraoral y orofaríngea. Objetivo: Analizar las características clínicas y patológicas del carcinoma epidermoide oral y orofaríngeo en Temuco, Chile. Material y Método: Estudio descriptivo, retrospectivo de todos los casos diagnosticados en 15 años (1994 y 2008), en el Hospital Regional de Temuco. Los pacientes fueron analizados de acuerdo a género, edad, y los tumores fueron clasificados basados en su localización anatómica, tamaño, características macroscópicas y grado de diferenciación. Resultados: Se encontraron 93 carcinomas, con relación hombre:mujer de 5:1, edad promedio 67 años. Pacientes menores a 50 años correspondían sólo al 8 por ciento de los casos. Las localizaciones más frecuentes fueron labio inferior, lengua y encía, con un tamaño promedio de 28 mm, el que aumentó hacia la orofarinx, más de la mitad eran moderadamente diferenciados. Conclusiones: En nuestra región, este carcinoma afecta con mayor frecuencia a la séptima década de la vida y a población masculina y posee características similares a las descritas en otros países donde predomina la raza blanca. El tamaño al diagnóstico es considerable. La detección de algunas diferencias en el grupo con apellidos mapuches amerita un estudio con un mayor número de casos.


Subject(s)
Humans , Male , Adult , Female , Middle Aged , Aged, 80 and over , Carcinoma, Squamous Cell/pathology , Oropharyngeal Neoplasms/pathology , Mouth Neoplasms/pathology , Age and Sex Distribution , Chile , Carcinoma, Squamous Cell/epidemiology , Oropharyngeal Neoplasms/epidemiology , Mouth Neoplasms/epidemiology , Retrospective Studies
13.
Mem. Inst. Oswaldo Cruz ; 106(2): 166-169, Mar. 2011. ilus, tab
Article in English | LILACS | ID: lil-583940

ABSTRACT

The purpose of this study was to compare the histopathological analysis with polymerase chain reaction (PCR) methods to predict the presence of human papillomavirus (HPV) infection in oral squamous cell carcinoma biopsies. Eighty-three paraffin-embedded tissue specimens from patients with oropharynx and mouth floor squamous cell carcinoma were submitted to histopathological analysis under light microscopy, specifically for the determination of the presence of koilocytes. Subsequently, DNA was purified from the same paraffin-embedded specimens and submitted to PCR. Fisher's exact test showed no statistically significant correlation between the two methods. The results suggest that the presence of koilocytes is unreliable for the detection of HPV presence in oral and oropharynx squamous cell carcinoma.


Subject(s)
Humans , Carcinoma, Squamous Cell , Mouth Neoplasms , Oropharyngeal Neoplasms , Papillomaviridae , Papillomavirus Infections , Biopsy , Carcinoma, Squamous Cell/pathology , DNA, Viral , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Polymerase Chain Reaction , Papillomaviridae , Papillomavirus Infections/pathology
14.
Asunción; s.e; 20100214. 52 p.
Monography in Spanish | LILACS, BDNPAR | ID: biblio-1018796

ABSTRACT

El cáncer es una enfermedad neooplásica, originadas por mutaciones genéticas que conduce a una proliferación celular descontrolada y a la formación de un tumor, que puede extenderse, evadiendo otros órganos y tejidos causando daños sestémicos. Esta enfermedad constituye una de las principales causa de muerte a nivel mundial, y su incidencia ha ido aumentando progresivamente en las últimas décadas, debido a numerosos factores; entre la cuales la dieta es uno de los más importantes. Existen fuertes evidencias epidemiológicas y experimentales, del efecto protector contra el cáncer que ejercen los alimentos de origen vegetal como hortalizas, frutas, legumbres y granos enteros de cereales. Los mismos constituyen fuentes de fibra, vitaminas y antioxidantes. Por otro lado, una dieta rica en carne roja, grasas de origen animal y embutidos, así como alimentos cocidos a muy alta temperatura(Asado y Fritura) y el alcohol han demostrado aumentar el riesgo de desarrollar la enfermedad. El cáncer oro faríngeo constituye el tercer tipo de neoplasia más frecuente en países en vías de desarrollo y es uno de los más influenciados por el hábito alimenticio del individuo. Se estima que un 35% de todos los casos de cáncer podrían ser evitados gracias a una buena alimentación. por lo que resulta evidente la necesidad de impulsar campañas de educación de la población destinada a mejorar los hábitos alimentarios fin de disminuir su incidencia en nuestro país.


Subject(s)
Humans , Neoplasms , Oropharyngeal Neoplasms , Oropharyngeal Neoplasms/pathology , Dentistry , Chemistry, Physical
15.
Acta cir. bras ; 23(4): 337-342, July-Aug. 2008. graf, tab
Article in English | LILACS | ID: lil-486170

ABSTRACT

PURPOSE: To investigate the carcinogenic action of hydrochloric acid, pepsin and sodium nitrate on the oropharyngeal mucosa of rats, simulating the reflux of gastric contents. METHODS: Eighty-two Wistar rats were divided in seven groups and submitted to 2 or 3 weekly applications of hydrochloric acid, pepsin and sodium nitrate on the pharyngeal mucosa during six months. Study groups comprised 12 animals each. Rats in groups I and II were submitted to 2 (GI) or 3 (GII) weekly applications of 0.1N hydrochloric acid. Groups III and IV were submitted to 2 (GIII) or 3 (GIV) weekly applications of 0.1N hydrochloric acid solution with pepsin. Groups V and VI were submitted to 2 (GV) or 3 (GVI) weekly applications of 0.1N hydrochloric acid and treated with daily nitrate diluted in water. Group VII consisted of 10 animals submitted to 2 weekly applications of filtered water. RESULTS: No dysplasia, intra-epithelial neoplasia or invasive carcinomas were detected. Inflammatory changes were observed in varying degrees and mast cells were more common in Groups V and VI (p=0.006). CONCLUSION: The data of the current study could not corroborate the hypothesis that gastroesophageal and pharyngolaryngeal refluxes are carcinogenic factors to the laryngopharyngeal mucosa, and more studies are necessary in the future.


OBJETIVO: Investigar a ação carcinogênica do ácido clorídrico, pepsina e nitrato de sódio na mucosa orofaríngea de ratos, simulando o refluxo do conteúdo gástrico à mucosa do faringo-laringea. MÉTODOS: Oitenta e dois ratos Wistar foram divididos em 7 grupos e submetidos a 2 ou 3 aplicações semanais de ácido clorídrico, pepsina e nitrato de sódio na mucosa orofaríngea durante 6 meses. Os grupos de estudo envolveram 12 animais cada. Os ratos nos grupos I e II foram submetidos à 2 (GI) ou 3 (GII) aplicações semanais de ácido clorídrico 0,1N. Nos grupos III e IV foram 2 (GIII) ou 3 (GIV) aplicações semanais de ácido clorídrico e pepsina. Nos grupos V e VI foram 2 (GV) ou 3 (GVI) aplicações semanais de ácido clorídrico além da oferta de nitrato diluído em água diariamente. Grupo VII era composto por 10 animais submetidos a 2 aplicações semanais de água filtrada. RESULTADOS: Não se observou displasia, neoplasia intra-epitelial ou neoplasia invasora. Alterações inflamatórias em graus variados foram observadas, com infiltrado mastocitário mais intenso nos grupos V e VI. (p=0,006). CONCLUSÃO: Os dados do presente estudo não confirmam a hipótese que o refluxo gastro-esofágico e faringo-laringeo são fatores carcinogênicos para a mucosa laringo-faringea e mais estudos são necessários no futuro.


Subject(s)
Animals , Male , Rats , Carcinogens/toxicity , Carcinoma, Squamous Cell/chemically induced , Gastrointestinal Agents/toxicity , Hydrochloric Acid/toxicity , Nitrates/toxicity , Oropharyngeal Neoplasms/chemically induced , Carcinogenicity Tests , Carcinoma, Squamous Cell/pathology , Drug Evaluation, Preclinical , Mouth Mucosa/pathology , Oropharyngeal Neoplasms/pathology , Pepsin A/toxicity , Random Allocation , Rats, Wistar
16.
ACM arq. catarin. med ; 37(2): 32-41, mar.-jun. 2008. tab
Article in Portuguese | LILACS | ID: lil-499747

ABSTRACT

Objetivo: Definir o perfil clínico e epidemiológico dos pacientes com diagnóstico de câncer de boca e orofaringe, atendidos em clínica de cirurgia de Cabeça e Pescoço. Métodos: Foram avaliados os prontuários dos pacientes com diagnóstico de carcinoma de boca e orofaringe atendidos no período de 2002 a 2006, em clínica decirurgia de Cabeça e Pescoço. Foram incluídos no estudo os prontuários de pacientes que foram submetidos, após o estadiamento da doença, a alguma modalidade de tratamento. Resultados: Entre os 28 casos incluídos no estudo,88,8% eram do gênero masculino, 85,7% eram caucasianos e a faixa etária mais acometida foi entre 51 e 60anos. A queixa de “ferida na boca” esteve presente em 88,8% dos casos de carcinoma de boca e odinofagia em80% dos casos de carcinoma de orofaringe. O tabagismo esteve presente em 92,8% e o etilismo em 85,7% dos pacientes. O sítio mais acometido na cavidade oral foi a língua (50%) e, na orofaringe, a amigdala e o palato mole (ambos com 40%). A maior parte dos pacientes foi submetida a tratamento cirúrgico radical (77,7%) com ou sem radioterapia adjuvante. O diagnóstico histopatológico, em aproximadamente 96% dos casos, indicou carcinoma espinocelular. Conclusões: Especial atenção dos profissionais de saúde, principalmente médicos e odontólogos, deve serdirecionada aos pacientes com idade maior que 50 anos, tabagistas e etilistas, com queixa de lesão na cavidade oral ou odinofagia persistente, com o objetivo de diagnósticosprecoces e maiores índices de tratamentos curativos, com menores taxas de morbidade e mortalidade.


Objective: It mains evaluate clinical and epidemiological factors of patients with oral cavity and oropharynx cancer that were trated in a head and neck surgeryclinic. Methods: The patients’ records that were taken care from 2002 to 2006 in head and neck surgery clinic andpatients with mouth and oropharynx carcinoma were evaluated. Results: Among 28 patients, 88,8% were men, 85,7% were caucasian, the average age was from 51 to 60, the complain about hurt in mouth was in 88,8% of the patients with oral cavity cancer and the odinofagia in 80% of the patients with oropharynx cancer.92,8% used tosmoke and 85,7% used to drink alcoholic drinks. The tongue was the most stricken part in oral cavity (50%), tonsil and soft palate (both 40%) in oropharynx. In the diagnose most of the patients were in advanced clinicalstaging cancer (III and IV) and infiltrating ulcer in both situations. Most of the patients were submitted to a radical the surgery treatment (77.7%) with or without adjuvant radiation therapy or chemotherapy. In almost 96% of the cases the histopathology diagnosis indicated squamous cell carcinoma. Conclusion: Special attention from the health professionals, mainly physicians and dentists, must be givento patients older than 50 years, smokers and alcoholic drunker, that complain about persistent oral hurt or odinofagiain an appointment to have a precocious diagnoses and higher ways of curative treatments, with lesser evidence of morbidity and mortality.


Subject(s)
Middle Aged , Mouth/injuries , Oropharyngeal Neoplasms/diagnosis , Oropharyngeal Neoplasms/pathology , Risk Factors , Mouth/physiology , Mouth/pathology , Epidemiologic Measurements , Oropharyngeal Neoplasms/surgery , Oropharyngeal Neoplasms/radiotherapy
17.
Rev. bras. otorrinolaringol ; 71(4): 510-519, jul.-ago. 2005. ilus, tab
Article in Portuguese | LILACS | ID: lil-419337

ABSTRACT

O papilomavírus humano (HPV) é universalmente aceito como agente causal do câncer de colo uterino e, recentemente, vem se especulando sobre sua possível relação com câncer oral e de orofaringe. O carcinoma espinocelular (CEC) oral representa 90 por cento de todos os tumores malignos que afetam a cavidade bucal. Estudos sobre a prevalência de HPV em pacientes com CEC variam de 0 a 100 por cento. O efeito citopático viral mais conhecido é a coilocitose, considerado "critério maior" na infecção pelo HPV do ponto de vista histopatológico. OBJETIVO: O objetivo deste estudo foi verificar a prevalência de achados sugestivos de HPV - coilocitose - em CEC oral e de orofaringe. FORMA DE ESTUDO: coorte transversal. MATERIAL E MÉTODO: Foram examinadas no microscópio 20 lâminas com o diagnóstico de CEC de cavidade oral ou orofaringe sendo que em 15 delas foi encontrada coilocitose, correspondendo a 75 por cento. RESULTADO: Apesar de termos conhecimento que o método com maior sensibilidade atual para pesquisa de HPV ser a reação de polimerase em cadeia (PCR), iniciamos esta pesquisa com a investigação de coilocitose, o que é muito sugestivo de infecção por HPV. CONCLUSÃO: O estudo em questão trata-se de um projeto-piloto pois será dada continuidade a esta pesquisa através da realização de PCR a fim de confirmar a alta prevalência de infecção por HPV em CEC oral e de orofaringe.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged, 80 and over , Carcinoma, Squamous Cell/pathology , Papillomavirus Infections/pathology , Mouth Neoplasms/pathology , Oropharyngeal Neoplasms/pathology , Papillomaviridae , Biopsy , Carcinoma, Squamous Cell/virology , Papillomavirus Infections/complications , Oropharyngeal Neoplasms/virology
18.
Article in English | IMSEAR | ID: sea-64658

ABSTRACT

Intestinal metastases are uncommon. Lungs and skin are the common sites of primary tumor. We report two men (52- and 67-year-old) with small bowel metastases from esophageal and oropharyngeal carcinomas.


Subject(s)
Aged , Carcinoma, Squamous Cell/secondary , Esophageal Neoplasms/pathology , Humans , Ileal Neoplasms/secondary , Male , Middle Aged , Oropharyngeal Neoplasms/pathology
19.
Medicina (B.Aires) ; 64(6): 521-524, 2005. ilus, tab
Article in Spanish | LILACS | ID: lil-444260

ABSTRACT

Signet ring cell lymphoma is a rare neoplasm characterized by large, vacuolated and clear cells mimicking mucin-producing adenocarcinoma. It is localized in nodal and extranodal sites. A case of a 59 years old male, with a diffuse lymphoma signet ring cell type localized on oropharyngeal mucosa is reported. The histopathology study showed signet ring cells and the immunophenotype was: vimentine(+), CD45(+), CD20(+), Ig M(+), Kappa chain(+) and high index proliferative activity of neoplastic cells (Ki 67:70%). After a review of the literature and previous reports, we could not find a similar case in this anatomic site. The patient had a unfavourable clinical course and died two months after the diagnosis without receiving any treatment.


El linfoma de células en anillo de sello es una neoplasia poco frecuente, caracterizada por la presensenciade grandes células de citoplasma vacuolado, claro, similar a los encontrados en adenocarcinomasmucosecretantes. Se ha descripto en ganglios linfáticos y tejidos extralinfáticos. Se presenta el casode un paciente varón de 59 años con linfoma de células en anillo de sello localizado en pared lateral de orofaringe.Esta localización creemos que no ha sido descripta anteriormente. La histología mostró células en anillo de sello y el inmunofenotipo tumoral fue: vimentina, CD45, CD20, Ig M y cadenas kappa positivos, siendo la fracción de crecimiento tumoral alta (Ki 67:70%). El paciente evolucionó desfavorablemente y falleció a los dosmeses del diagnóstico sin recibir tratamiento.


Subject(s)
Humans , Male , Middle Aged , Adenocarcinoma, Mucinous/pathology , Carcinoma, Signet Ring Cell/pathology , Lymphoma, B-Cell/pathology , Oropharyngeal Neoplasms/pathology , Diagnosis, Differential , Treatment Outcome
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