Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 103
Filter
1.
Int. j. morphol ; 41(2): 660-667, abr. 2023. ilus, tab
Article in English | LILACS | ID: biblio-1440325

ABSTRACT

SUMMARY: The aim of this systematic review was to assess the histological effects of platelet-rich plasma (PRP) on temporomandibular joint osteoarthritis (TMJ-OA) in animal models. A systematic search was performed using PubMed, WoS, EMBASE, Science Direct and SCOPUS databases. The inclusion criteria were experimental studies in animal models that evaluated the use of PRP as a treatment for TMJ-OA with or without arthrocentesis/arthroscopy. Comparison was made to a healthy control group or to other treatment. The variables evaluated were the histological effects of the treatments, characteristics of the primary articles, characteristics of the sample studied and the risk of bias. The systematic search identified 120 studies. Eventually 5 studies were included in the analysis. Four of the studies showed a statistically significant repair in joint tissues and improvement of cartilage thickness in animals treated with PRP. The global risk of bias was unclear. The results of this systematic review suggest that PRP treatment in TMJ-OA has benefits at the histological level in cartilage, articular disc and articular bone tissue in animal models. However, due to the low number of studies and the risk of bias, further research is needed to recommend its use.


El objetivo de esta revisión sistemática fue evaluar los efectos histológicos del plasma rico en plaquetas (PRP) en la osteoartritis de la articulación temporomandibular (ATM-OA) en modelos animales. Se realizó una búsqueda sistemática en las bases de datos PubMed, WoS, EMBASE, Science Direct y SCOPUS. Los criterios de inclusión fueron estudios experimentales en modelos animales que evaluaran el uso de PRP como tratamiento para la ATM-OA con o sin artrocentesis/ artroscopia. La comparación se realizó con un grupo de control sano o con otro tratamiento. Las variables evaluadas fueron los efectos histológicos de los tratamientos, las características de los artículos primarios, las características de la muestra estudiada y el riesgo de sesgo. La búsqueda sistemática identificó 120 estudios. Finalmente se incluyeron 5 estudios en el análisis. Cuatro de los estudios mostraron una reparación estadísticamente significativa en los tejidos articulares y una mejora del grosor del cartílago en los animales tratados con PRP. El riesgo global de sesgo fue incierto. Los resultados de esta revisión sistemática sugieren que el tratamiento con PRP en la ATM-OA tiene beneficios a nivel histológico en el cartílago, el disco articular y el tejido óseo articular en modelos animales. Sin embargo, debido al escaso número de estudios y al riesgo de sesgo, se necesitan investigaciones adicionales para recomendar su uso.


Subject(s)
Animals , Osteoarthritis/therapy , Temporomandibular Joint/anatomy & histology , Temporomandibular Joint Disorders/therapy , Platelet-Rich Plasma/physiology , Disease Models, Animal
2.
Chinese journal of integrative medicine ; (12): 368-376, 2023.
Article in English | WPRIM | ID: wpr-982271

ABSTRACT

Lower limb osteoarthritis (OA) is a chronic, multifactorial disease characterized by impaired physical function, chronic pain, compromised psychological health and decreased social functioning. Chronic inflammation plays a critical role in the pathophysiology of OA. Tai Chi is a type of classical mind-body exercise derived from ancient Chinese martial arts. Evidence supports that Tai Chi has significant benefits for relieving lower limb OA symptoms. Using a biopsychosocial framework, this review aims to elucidate the beneficial effects of Tai Chi in lower limb OA and disentangle its potential mechanisms from the perspective of biology, psychology, and social factors. Complex biomechanical, biochemical, neurological, psychological, and social mechanisms, including strengthening of muscles, proprioception improvement, joint mechanical stress reduction, change of brain activation and sensitization, attenuation of inflammation, emotion modulation and social support, are discussed.


Subject(s)
Humans , Tai Ji , Osteoarthritis/therapy , Exercise Therapy , Lower Extremity , Chronic Disease , Inflammation
3.
Rev. bras. ortop ; 57(4): 540-545, Jul.-Aug. 2022. graf
Article in English | LILACS | ID: biblio-1394866

ABSTRACT

Abstract The indication of shoulder arthroplasties has increased progressively. Accurate positioning of the components may have significant implications for clinical results. The navigation used to aid in the performance of anatomical and reverse total arthroplasties has provided greater precision in implant placement, especially on the glenoid. The development of the technique, material, and prosthesis design have shown encouraging results and led to a trend toward its expansion. In this way, we estimate a higher survival of the arthroplasties resulting from lower rates of dislocation and early loosening. We aim to describe the current technique and to present the results of the literature with navigation. However, comparative clinical studies with long term follow-up are necessary to prove the efficacy in the final results of total shoulder arthroplasties.


Resumo A indicação de artroplastias do ombro aumentou progressivamente. O posicionamento preciso dos componentes pode ter implicações significativas para os resultados clínicos. A navegação utilizada para auxiliar no desempenho de artroplastias totais anatômicas e reversas tem proporcionado maior precisão na colocação do implante, especialmente do componente glenoidal. O desenvolvimento da técnica, do material e do desenho da prótese têm mostrado resultados encorajadores e levado a uma tendência de expansão da sua utilização. Dessa forma, estimamos uma maior sobrevida das artroplastias resultantes de menores taxas de instabilidade e soltura precoce. Nosso objetivo é descrever a técnica atual e apresentar os resultados da literatura com navegação. No entanto, estudos clínicos comparativos com acompanhamento de longo prazo são necessários para comprovar a eficácia nos resultados finais das artroplastias totais do ombro.


Subject(s)
Humans , Osteoarthritis/therapy , Prosthesis Design , Shoulder/surgery , Arthroplasty, Replacement, Shoulder/methods
4.
Rev. bras. ortop ; 57(3): 402-408, May-June 2022. tab, graf
Article in English | LILACS | ID: biblio-1388020

ABSTRACT

Abstract Objective The present study aimed to compare the effects of intraarticular infiltration of platelet-rich plasma with those of hyaluronic acid infiltration in the treatment of patients with primary knee osteoarthritis. Methods A randomized clinical trial was conducted with 29 patients who received an intraarticular infiltration with hyaluronic acid (control group) or platelet-rich plasma. Clinical outcomes were assessed using the visual analog scale for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire before and after the intervention. In addition, the posttreatment adverse effects were recorded. Categorical variables were analyzed using the chi-square and Fisher exact tests, whereas continuous variables were analyzed using the Student t test, analysis of variance, and the Wilcoxon test; all calculations were performed with the Stats package of the R software. Results An independent analysis of each group revealed a statistical difference within the first months, with improvement in the pain and function scores, but worsening on the 6th month after the procedure. There was no difference in the outcomes between the groups receiving hyaluronic acid or platelet-rich plasma. There was no serious adverse effect or allergic reaction during the entire follow-up period. Conclusion Intraarticular infiltration with hyaluronic acid or platelet-rich plasma in patients with primary knee gonarthrosis resulted in temporary improvement of functional symptoms and pain. There was no difference between interventions.


Resumo Objetivo Comparar o efeito da infiltração intraarticular do plasma rico em plaqueta com a do ácido hialurônico no tratamento de pacientes com osteoartrose primária de joelho. Métodos Realizou-se um ensaio clínico randomizado com 29 pacientes, sendo um grupo submetido à infiltração com ácido hialurônico (controle) e o outro com plasma rico em plaquetas. Os desfechos clínicos avaliados foram a escala visual analógica da dor; o questionário Western Ontario and McMaster Universities Arthritis Index (WOMAC), antes e depois da intervenção; e os efeitos adversos após as aplicações. Utilizou-se os testes do qui-quadrado e exato de Fisher para as variáveis categóricas, e o teste t de Student, análise de variância, e Wilcoxon para as variáveis contínuas, através do software R. Resultados A análise independente de cada grupo revelou uma diferença estatística nos meses iniciais, com melhora dos escores de dor e função; porém, com piora no 6° mês após o procedimento. Não houve diferença dos desfechos avaliados entre os grupos que foram submetidos à infiltração com ácido hialurônico ou com plasma rico em plaquetas. Não houve efeito adverso grave ou reação alérgica durante todo o seguimento. Conclusão A infiltração intraarticular com ácido hialurônico ou plasma rico em plaquetas nos joelhos dos pacientes com gonartrose primária apresentou melhora temporária dos sintomas de função e dor. Não houve diferença entre as duas intervenções.


Subject(s)
Humans , Osteoarthritis/therapy , Benchmarking , Platelet-Rich Plasma/drug effects , Hyaluronic Acid/therapeutic use , Anesthesia, Local , Knee/pathology
5.
Rev. bras. ortop ; 57(2): 345-347, Mar.-Apr. 2022. graf
Article in English | LILACS | ID: biblio-1387985

ABSTRACT

Abstract The differential diagnosis of dorsal thoracic pain can be a challange due to the proximity of the dorsal column to vital organs as well as to its unique anatomy, innervation, and rib joint. The patterns of referred visceral pain require, in most cases, extensive complementary diagnostic tests in order to exclude severe conditions. Referred pain patterns often result in numerous and expensive visceral workups in order to exclude serious conditions, and costovertebral joint osteoarthritis is usually only considered when the origin of the pain remains unexplained. The authors present the case of a 40-year-old man with disabling dorsal pain due to isolated costovertebral osteoarthrosis. The symptomatology was controlled after injection of methylprednisolone guided by computed tomography. This clinical case aims to describe the clinical presentation of a rare entity that should be considered in the differential diagnosis of back pain.


Resumo O diagnóstico diferencial de dorsalgia revela-se um desafio pela proximidade da coluna dorsal a órgãos vitais assim como por sua anatomia única, inervação e articulação com as costelas. Os padrões de dor referida visceral obrigam, na maioria das vezes, a extensivos exames complementares de diagnóstico de forma a excluir condições graves. A osteoartrose da articulação costovertebral é um diagnóstico pouco reconhecido, e habitualmente é somente considerado quando a fonte de dor continua sem explicação após extensa investigação. Os autores apresentam o caso de um homem de 40 anos de idade com dor dorsal incapacitante devido a osteoartrose costovertebral isolada. A sintomatologia foi controlada após a injeção de metilprednisolona guiada por tomografia computadorizada. Este caso clínico tem como objetivo descrever a apresentação clínica de uma entidade rara que deverá ser considerada no diagnóstico diferencial de dorsalgia.


Subject(s)
Humans , Male , Adult , Osteoarthritis/therapy , Thoracic Vertebrae/pathology , Back Pain , Diagnosis, Differential , Lumbar Vertebrae/pathology
6.
Rev. bras. ortop ; 57(2): 348-350, Mar.-Apr. 2022. graf
Article in English | LILACS | ID: biblio-1387998

ABSTRACT

Abstract Arthroscopy-assisted partial wrist-fusion techniques are becoming more popular nowadays. It became clearer that avoiding the violation of important ligament and tendinous structures - which is impossible when using the classic open techniques - enables a more biological approach, which is essential for faster healing and improvement in function. We describe the use of the triquetrum-hamate (TH) portal, which is seldomly applied in routine arthroscopic techniques for hand and wrist surgery, as an accessory portal to better perform anterior midcarpal debridement in four-corner fusion. This trick enables an almost complete anterior resection of the capitate and hamate chondral surfaces, increasing the subchondral osseous contact in the midcarpal joint after fixation, thus leading to higher consolidation rates.


Resumo As técnicas de fusão parcial do punho assistidas por artroscopia estão se tornando mais populares. Ficou claro que evitar a violação de importantes estruturas ligamentares e tendíneas, o que é imposssível com as técnicas abertas clássicas, permite uma abordagem mais biológica, essencial para a cicatrização mais rápida e melhora da função. Descrevemos o uso do portal piramidal-hamato (PH), raramente aplicado em técnicas artroscópicas de rotina para cirurgia de mão e punho, como portal acessório para melhor execução do desbridamento carpal medial anterior na fusão de quatro cantos. Esse truque possibilita a ressecção anterior quase completa das superfícies condrais do capitato e do hamato, o que aumenta o contato ósseo subcondral na articulação mesocárpica após a fixação e eleva as taxas de consolidação.


Subject(s)
Humans , Osteoarthritis/therapy , Arthroscopy/methods , Wrist Injuries/surgery , Wrist Joint/surgery
7.
Rev. bras. ortop ; 56(6): 689-696, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1357130

ABSTRACT

Abstract Osteoarthritis (OA) is characterized by a chronic, progressive and irreversible degradation of the joint surface associated with joint inflammation. The main etiology of ankle OA is post-traumatic and its prevalence is higher among young and obese people. Despite advances in the treatment of fractures around the ankle, the overall risk of developing posttraumatic ankle OA after 20 years is almost 40%, especially in Weber type B and C bimalleolar fractures and in fractures involving the posterior tibial border. In talus fractures, this prevalence approaches 100%, depending on the severity of the lesion and the time of follow-up. In this context, the current understanding of the molecular signaling pathways involved in senescence and chondrocyte apoptosis is fundamental. The treatment of ankle OA is staged and guided by the classification systems and local and patient conditions. The main problems are the limited ability to regenerate articular cartilage, low blood supply, and a shortage of progenitor stem cells. The present update summarizes recent scientific evidence of post-traumatic ankle OA with a major focus on changes of the synovia, cartilage and synovial fluid; as well as the epidemiology, pathophysiology, clinical implications, treatment options and potential targets for therapeutic agents.


Resumo A osteoartrite (OA) é caracterizada por uma degradação crônica, progressiva e irreversível da superfície articular, associada a inflamação articular. A principal etiologia da OA do tornozelo é pós-traumática e sua prevalência é maior entre os jovens e obesos. Apesar dos avanços no tratamento das fraturas ao redor do tornozelo, o risco geral de desenvolver OA pós-traumática do tornozelo após 20 anos do trauma é de quase 40%; especialmente nas fraturas bimaleolares de Weber tipo B e C e fraturas envolvendo a borda tibial posterior. Nas fraturas do tálus, essa prevalência se aproxima de 100%, dependendo da gravidade da lesão e do tempo de seguimento. Nesse cenário, é fundamental a compreensão atual das vias de sinalização moleculares envolvidas na senescência e apoptose dos condrócitos. O tratamento da OA do tornozelo é estagiado e guiado pelos sistemas de classificação, condições locais e do paciente. Os principais problemas são a limitada capacidade de regeneração da cartilagem articular, o baixo suprimento de sangue e a escassez de células-tronco progenitoras. A presente atualização resume evidências científicas básicas recentes da OA póstraumática do tornozelo, com foco principal nas alterações metabólicas da sinóvia, da cartilagem e do líquido sinovial. Epidemiologia, fisiopatologia, implicações clínicas, e opções de tratamento são também discutidas.


Subject(s)
Humans , Osteoarthritis/diagnosis , Osteoarthritis/therapy , Synovial Fluid , Cartilage , Cartilage, Articular , Prevalence , Fractures, Bone , Ankle Fractures , Ankle/physiopathology
8.
Rev. bras. ortop ; 56(2): 133-137, Apr.-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1251352

ABSTRACT

Abstract Medial arthrosis of the knee is an evolutionary pathology that occurs due to progressive muscle imbalance. The muscles of the knee region have a large imbalance caused by the difference of power and lever arm. With the progression of life, this imbalance manifests itself more importantly, especially due to the loss of muscle strength due to aging. Pathological postures begin to occur and determine areas of support and pressure harmful to the joint. Meniscal injury is typical in the evolution of this pathology, as well as cartilage injury. The recognition of this pathology enables good results with less aggressive treatments, such as correction of muscle imbalance and consequent reeducation of joint support. Economic and partial meniscectomy brings good results in the early stages of the degenerative process. Progressive evolution leads to knee degeneration and the consequent need for broader surgeries.


Resumo A artrose medial do joelho é uma patologia evolutiva que ocorre em decorrência de desequilíbrio muscular progressivo. Os músculos da região do joelho têm um grande desequilíbrio, provocado pela diferença de potência e braço de alavanca. Com a progressão da vida, este desequilíbrio se manifesta de forma mais importante, especialmente em decorrência da perda de força muscular em função do envelhecimento. Posturas patológicas passam a ocorrer e determinar zonas de apoio e pressão lesivas para a articulação. A lesão meniscal é típica na evolução desta patologia, assim como a lesão da cartilagem. O reconhecimento desta patologia possibilita resultados bons com tratamentos menos agressivos, como a correção do desequilíbrio muscular e consequente reeducação do apoio da articulação. A meniscectomia econômica e parcial traz bons resultados nas fases iniciais do processo degenerativo. A evolução progressiva leva à degeneração do joelho e à consequente necessidade de cirurgias mais amplas.


Subject(s)
Osteoarthritis/diagnosis , Osteoarthritis/therapy , Osteonecrosis , Meniscus/injuries
9.
China Journal of Orthopaedics and Traumatology ; (12): 1171-1178, 2021.
Article in Chinese | WPRIM | ID: wpr-921944

ABSTRACT

OBJECTIVE@#To investigate the effect of the exosomes from bone marrow mesenchymal stem cells (BMSCs) transfected with silence plasmid of Piezol small interference RNA (siRNA)on osteoarthritis (OA) animal model.@*METHODS@#Twenty male SD rats with specific pathogen free (SPF) were selected, ranging in age from 5.46 to 6.96 months, with a mean of (6.21± 0.75) months;and ranging in weight from 385.76 g to 428.66 g, with a mean of (407.21±21.45) g. BMSCs were extracted. The siRNA silencing plasmid of piezo1 was constructed by siRNA technology. After lentivirus was transfected into BMSCs, the exosomes were extracted. At the cellular level, BMSCs were divided into blank plasmid group and siRNA silencing plasmid group according to whether siRNA-Piezo1 was transfected or not. The osteogenic induction ability of siRNA-Piezo1 on BMSCs was detected by RT-PCR and Western blot. At the animal model level, the OA model was established by surgical resection of cruciate ligament of knee joint.According to different treatment schemes, SD rats were divided into 4 groups:blank control group, model group, BMSCs group and exosome group. SD rats in the blank control group were not treated. In the model group, the cruciate ligaments of rats were excised and OA animal model was established. In BMSCs group, BMSCs were injected into knee joint under CT guidance after OA model establishment, and the cell volume was 5×10@*RESULTS@#The lentivirus transfection efficiency was(92.11±4.22)%. RT-PCR showed that the relative expression of Piezo1 mRNA in blank plasmid group was 1.07±0.06, which was significantly different from that of 0.31±0.01 in siRNA silencing plasmid group (@*CONCLUSION@#Piezo1 siRNA silencing vector can promote the differentiation of BMSCs into chondrocytes and effectively inhibit the progression of OA, so as to delay the disease of OA.


Subject(s)
Animals , Male , Rats , Chondrocytes , Disease Models, Animal , Exosomes/genetics , Mesenchymal Stem Cells , Osteoarthritis/therapy , RNA, Small Interfering/genetics , Rats, Sprague-Dawley , Tomography, X-Ray Computed
10.
Medisan ; 24(5) tab
Article in Spanish | LILACS, CUMED | ID: biblio-1135201

ABSTRACT

Introducción: La artrosis vertebral es frecuente. Las causas y procesos fisiopatológicos que contribuyen a su avance son variados. Se plantea que 80 % de las personas mayores de 55 años de edad presentan alteraciones en la columna cervical. Objetivo: Evaluar la efectividad de la ozonopuntura para el alivio de síntomas y signos en pacientes con artrosis cervical. Métodos: Se realizó un estudio de intervención terapéutica en 80 pacientes con artrosis cervical, atendidos en la Consulta de Ortopedia y remitidos al Servicio de Medicina Tradicional y Natural del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, desde mayo del 2017 hasta marzo del 2019. Se dividieron aleatoriamente en 2 grupos: de estudio y de control, con 40 integrantes cada uno. Resultados: La enfermedad prevaleció en los pacientes de 50-59 años de edad, tanto del grupo de estudio como de control (35,0 y 30,0 %, respectivamente) y en el sexo femenino (85,0 % en el primero y 82,5 % en el segundo). La evolución fue buena y excelente en casi la totalidad de los integrantes del grupo de estudio. Conclusiones: La ozonopuntura fue efectiva en los pacientes con artrosis cervical y no se presentaron reacciones secundarias relacionadas con su aplicación. La evolución resultó satisfactoria y se observó una respuesta mayor en la desaparición de los síntomas y signos clínicos con la terapéutica acupuntural que con la convencional.


Introduction: The vertebral osteoarthritis is frequent. The pathophysiological causes and processes that contribute to its advance are varied. It is said that the 80 % of people over 55 years present cervical spine disorders. Objective: To evaluate the effectiveness of the ozonepuncture for the relief of symptoms and signs in patients with cervical osteoarthritis. Methods: A study of therapeutic intervention in 80 patients with cervical osteoarthritis was carried out, they were assisted in the Orthopedics Service and referred to the Traditional and Natural Medicine Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, from May, 2017 to March, 2019. They were divided at random in 2 groups: study and control groups, with 40 members each one. Results: The disease prevailed in the 50-59 age group, in both groups (35.0 and 30.0 %, respectively) and in the female sex (85.0 % in the first one and 82.5 % in the second). The clinical course was good and excellent in almost all the members of the study group. Conclusions: The ozonepuncture was effective in the patients with cervical osteoarthritis and adverse reactions related to its application were not presented. The clinical course was satisfactory and a higher response was observed in the disappearance of the symptoms and clinical signs with the acupuntural therapeutic than with the conventional one.


Subject(s)
Osteoarthritis/therapy , Ozone/therapeutic use , Cervical Vertebrae/injuries , Acupuncture
11.
Rev. cuba. med ; 59(1): e1323, ene.-mar. 2020. tab
Article in Spanish | CUMED, LILACS | ID: biblio-1139039

ABSTRACT

Introducción: La osteoartritis es una de las principales causas de dolor y discapacidad en el mundo. La ozonoterapia actúa como medio terapéutico, mejora la calidad del cartílago articular, disminuye la inflamación producida y presenta propiedades moduladoras del sistema inmune. Objetivo: Evaluar los resultados de la ozonoterapia rectal en pacientes con osteoartritis. Método: Se realizó un estudio descriptivo prospectivo, en el Servicio de Reumatología del Hospital Clínico Quirúrgico Lucía Iñiguez Landín, de Holguín en el período comprendido de julio de 2017 a febrero de 2019. La población del estudio quedó conformada por 101 pacientes. La muestra fue de 60 pacientes, seleccionada según un muestreo aleatorio simple. Resultados: La articulación más afectada fue la rodilla en 100 por ciento de los pacientes estudiados. El mayor número de pacientes presentaba discapacidad física moderada (53,3 por ciento) al inicio del tratamiento y a los 3 meses predominó la discapacidad ligera (26,6 (por ciento). Se logra reducir el uso de analgésicos de forma ocasional al concluir tratamiento. Conclusiones: En los pacientes con discapacidad funcional por osteoartritis tratados con ozonoterapia transrectal el efecto terapéutico fue muy bueno(AU)


Introduction: Osteoarthritis is one of the main causes of pain and disability worldwide. Ozone therapy acts as a therapeutic means, improves the quality of articular cartilage, reduces the resulting inflammation and has modulating properties of the immune system. Objective: To evaluate the results of rectal ozone therapy in patients with osteoarthritis. Method: A prospective descriptive study was carried out in the Rheumatology Service of Lucía Iñiguez Landín Surgical Clinical Hospital, in Holguín from July 2017 to February 2019. One hundred one patients consisted the study population. Sixty patients formed the sample, selected according to a simple random sampling. Results: The most affected joint was the knee in 100 percent of the studied patients. The highest number of patients had moderate physical disability (53.3 percent) at the start of treatment and at 3 months later, mild disability predominated (26.6 percent). It was possible to reduce the use of pain relievers occasionally at the end of treatment. Conclusions: The therapeutic effect of transrectal ozone therapy was very good in patients with functional disability due to osteoarthritis(AU)


Subject(s)
Humans , Male , Female , Osteoarthritis/diagnosis , Osteoarthritis/therapy , Ozone/therapeutic use , Epidemiology, Descriptive , Prospective Studies
12.
Rev. cuba. reumatol ; 22(supl.1): e857,
Article in Spanish | LILACS, CUMED | ID: biblio-1280388

ABSTRACT

La osteoartritis se considera una de las principales causas de discapacidad funcional. Es una enfermedad crónica y degenerativa que presenta un pico de incidencia en personas mayores de 60 años. El propósito de este trabajo es mostrar los avances en la terapia de pacientes con osteoartritis basada en ácido hialurónico para pacientes con osteoartritis. El ácido hialurónico posee funciones en la articulación que abarcan la lubricación, servir como relleno de espacio para permitir que la articulación permanezca abierta y la regulación de actividades celulares como la unión de proteínas. Cada vez hay más pruebas de que, dentro del espectro de derivados disponibles del ácido hialurónico, la eficacia de los productos de ácido hialurónico con un alto peso molecular es superior a la eficacia de los derivados con un bajo peso molecular. Aprovechando el control espacial de ciertos tipos de hidrogeles de ácido hialurónico, se están desarrollando sistemas de microdispositivos que pueden encapsular células madre embrionarias viables y luego recuperarlas mediante interrupción mecánica. Estas células madre podrían usarse para el tratamiento de enfermedades como la osteoartritis. El ácido hialurónico es un fármaco que puede para ayudar a reducir los efectos secundarios de la osteoartritis(AU)


Osteoarthritis is considered one of the main causes of functional disability. Osteoarthritis conceptualized as a chronic and degenerative disease that presents a peak incidence in people older than 60 years. To show advances in hyaluronic acid-based therapy for patients with osteoarthritis. Hyaluronic acid has functions in the joint that include lubrication, which serves as a filling of space to allow the joint to remain open and the regulation of cellular activities such as protein binding. Hyaluronic acid is a potential drug to help reduce the side effects of osteoarthritis(AU)


Subject(s)
Humans , Middle Aged , Aged , Osteoarthritis/therapy , Hydrogels , Hyaluronic Acid/therapeutic use , Ecuador
13.
Brasília; Fiocruz Brasília;Instituto de Saúde de São Paulo; dez. 3, 2019. 34 p.
Non-conventional in Portuguese | LILACS, ColecionaSUS, PIE, MTYCI | ID: biblio-1118203

ABSTRACT

O yoga caracteriza-se como uma prática integrativa de origem oriental que combina posições corporais, técnicas de respiração, meditação e relaxamento. É indicada no tratamento de sistemas musculoesquelético, endócrino, respiratório, além de outros agravos à saúde, e estimula as funções cognitivas. Qual a eficácia/efetividade e a segurança do yoga para tratamento da dor aguda ou crônica em população adulta? As buscas foram realizadas nas bases de dados Pubmed, HSE-Health Systems Evidence, Epistemonikos, Portal Regional da BVS, HE-Health Evidence e Embase, em 27 de setembro de2019. Foram incluídas revisões sistemáticas (RS), com ou sem metanálises, publicadas em inglês, espanhol e português, e que que avaliavam o yoga no tratamento de dor crônica e aguda na população adulta e/ou idosa. Não houve restrição em relação ao ano de publicação. As estratégias de busca foram utilizadas com base na combinação de palavras-chave estruturadas a partir do acrônimo PICOS, usando os termos MeSH no Pubmed e DeCS na BVS, adaptando-os ao HSE, Epistemonikos, HE e Embase. A qualidade metodológica das revisões sistemáticas selecionadas foi avaliada segundo a ferramenta Assessing the Methodological Quality of Systematic Reviews(AMSTAR 2). De 693 artigos identificados, dez revisões sistemáticas foram selecionadas, oito delas com meta-análises. Com relação à qualidade metodológica, três revisões foram consideradas de qualidade moderada, duas de baixa qualidade e cinco de qualidade criticamente baixa. Na lombalgia crônica, a prática de yoga, quando comparada a atividades passivas, cuidado habitual, educação, atendimento médico padrão, controle de atenção, lista de espera, sem exercícios físicos, mostrou ser eficaz na diminuição da dor em curto, médio e longo prazos. Os resultados são mais consistentes com relação aos efeitos em curto e médio prazos. Na comparação de yoga com exercícios físicos as evidências resultam de poucos estudos e são controversas, mostrando benefício em curto e médio prazos no controle de lombalgia ou diferenças estatisticamente não significantes. Yoga, em comparação a intervenções passivas, sem exercícios físicos, mostrou ser benéfico também para melhorar quadros de incapacidade específica relacionada à lombalgia, em curto, médio e longo prazos. Além disso, houve melhora clínica dos casos de lombalgia a favor de yoga em curto e médio prazos. Na dor cervical crônica, as revisões mostraram evidências de efeitos benéficos de yoga para redução da dor quando comparado a cuidados habituais ou exercícios, entretanto não houve diferença com pilates ou medicina complementar e alternativa Da mesma forma, yoga mostrou-se superior a cuidados habituais e exercícios na redução da incapacidade relacionada dor cervical. A qualidade de vida e o humor melhoraram com yoga em relação a cuidados habituais. Yoga parece trazer benefícios também para pessoas com quadros de dor relacionados a osteoartrite e artrite reumatoide, fibromialgia, síndromes do túnel do carpo e do intestino irritável. No entanto, os resultados são menos consistentes. Com relação à segurança da prática de yoga, as evidências mostraram eventos adversos em geral sem gravidade. E quando comparado a exercícios não houve diferença no relato de eventos adversos. As revisões sistemáticas apresentaram resultados favoráveis à prática de yoga em relação aos cuidados habituais, particularmente nos casos de dor lombar e cervical. Há menos evidências acerca da superioridade do yoga em comparação a intervenções ativas. Em outras situações estudadas, como a dor associada a fibromialgia, osteoartrite, artrite reumatoide, síndromes do túnel do carpo e do intestino irritável, as evidências são menos consistentes. É importante ressaltar que as revisões sistemáticas incluídas nesta revisão rápida foram consideradas de baixa confiança na avaliação com a ferramenta AMSTAR 2. Além disso, os resultados têm como base estudos primários com amostras pequenas, com heterogeneidade na aplicação das intervenções, e considerável risco de viés. Isso remete à necessidade de se realizar ensaios clínicos, bem como revisões sistemáticas, com melhor qualidade metodológica


Subject(s)
Humans , Adult , Middle Aged , Aged , Yoga , Acute Pain/therapy , Chronic Pain/therapy , Osteoarthritis/therapy , Arthritis, Rheumatoid/therapy , Carpal Tunnel Syndrome/therapy , Fibromyalgia/therapy , Treatment Outcome , Low Back Pain/therapy , Neck Pain/therapy , Irritable Bowel Syndrome/therapy
14.
Rev. cuba. reumatol ; 21(2): e91, mayo.-ago. 2019.
Article in Spanish | LILACS, CUMED | ID: biblio-1093817

ABSTRACT

Introducción: la osteoartrosis es la más frecuente de las enfermedades articulares. Objetivo: exponer los referentes bibliográficos que actualmente se refieren a la osteoartrosis en el marco de la revisión de literatura realizada. Desarrollo: como síndrome anatomoclínico se identifica por dolor mecánico que usualmente se relaciona con rigidez y que provoca poco a poco una pérdida o mengua de la función articular. Diversos factores de riesgo se relacionan con el progreso de esta enfermedad entre los que destacan, además de la edad y el sexo femenino, la obesidad, los microtraumas repetitivos en la práctica de determinados deportes y el cumplimiento de actividades profesionales específicas. Conclusiones: el tratamiento de la osteoartrosis debería ejecutarse a nivel de medicina familiar, tanto en el componente preventivo, como en el del control y manejo conservador, instruyendo al paciente en sus cuidados y acciones diarias y operando esquemas de medicamentos, ejercicios, apoyos funcionales como rodilleras, bastones y andadores. La educación médica debe asumir este paradigma, y no solicitar acto seguido la interconsulta a la especialidad cuando el paciente no responde, sin tener en cuenta que el manejo del paciente con artrosis se encuentra distante de la prescripción farmacológica(AU)


Introduction: osteoarthrosis is the most frequent joint disease. Objective: to expose the bibliographic references that currently refer to osteoarthrosis in the framework of the literature review carried out. Development: as anatomoclinic syndrome is identified by mechanical pain that is usually related to stiffness and that gradually causes a loss or decline of joint function. Several risk factors are related to the progress of this disease, among which stand out, in addition to age and female sex, obesity, repetitive microtrauma in the practice of certain sports and compliance with specific professional activities. Conclusions: treatment of osteoarthrosis should be carried out at the level of family medicine, both in the preventive component, as well as in the control and conservative management, instructing the patient in his daily care and actions and operating medication schemes, exercises, functional supports such as knee pads, canes and walkers. The medical education must assume this paradigm, and not immediately request the interconsultation to the specialty when the patient does not respond, without taking into account that the management of the patient with osteoarthritis is distant from the pharmacological prescription(AU)


Subject(s)
Humans , Male , Female , Osteoarthritis/prevention & control , Exercise , Osteoarthritis/therapy , Education, Medical , Conservative Treatment/methods
15.
Rev. cient. odontol ; 7(1): 121-131, ene.-jun. 2019.
Article in Spanish | LILACS, LIPECS | ID: biblio-1005981

ABSTRACT

Este artículo involucra una revisión de los factores etiológicos asociados a la osteoartritis (OA) de la articulación temporomandibular (ATM), así como los hallazgos imagenológicos, los cuales son indispensables para el diagnóstico y la determinación de la etapa de evolución de esta patología. Además, se discuten los métodos de tratamiento invasivos y no invasivos. Los objetivos del presente artículo fueron describir los métodos de diagnóstico y tratamiento más actuales y eficientes para la osteoartritis de la articulación temporomandibular, y determinar la existencia de la correlación clínica e imagenológica en las diferentes etapas de esta patología. A partir de una revisión de la literatura, se encontró que el método de diagnóstico más relevante para la OA de la ATM es la tomografía computarizada de haz cónico (TCHC), por sus múltiples ventajas. El método de tratamiento más eficiente durante la etapa sintomatológica de la enfermedad es la artrocentesis sinergizada con ácido hialurónico o plasma rico en plaquetas. Cabe resaltar que no se encontraron correlaciones directas suficientes entre los cambios óseos y la sintomatología clínica de la OA de ATM empleando la TCHC. (AU)


The objectives of this article were to describe the most current and efficient diagnostic and treatment methods for osteoarthritis of the temporomandibular joint (TMJ) and to determine the correlation of clinical and imaging in the different stages of this pathology. We review the etiological factors associated with osteoarthritis (OA) of the TMJ as well as the imaging findings, which are essential for the diagnosis and determination of the stage of evolution of this pathology. In addition, invasive and noninvasive treatment methods are discussed. Based on review of the literature, the most relevant diagnostic method for OA of the TMJ is conic beam computed tomography (CBCT), due to its multiple advantages. The most efficient treatment method during the symptomatic stage of the disease is arthrocentesis synergized with hyaluronic acid or plateletrich plasma. It was of note that no direct correlation was found between bone changes and the clinical symptomatology of TMJ OA using CBCT. (AU)


Subject(s)
Humans , Osteoarthritis/therapy , Osteoarthritis/diagnostic imaging , Temporomandibular Joint , Magnetic Resonance Spectroscopy , Cone-Beam Computed Tomography , Arthrocentesis
16.
Clinics ; 74: e722, 2019. tab, graf
Article in English | LILACS | ID: biblio-1001822

ABSTRACT

OBJECTIVES: This study aimed to provide evidence for understanding how to treat osteoarthritis (OA) in our country. Therefore, it was necessary to match information and investigations related to the treatment of the disease from the three main types of specialists involved: physiatrists, orthopedists and rheumatologists. METHODS: The authors acted as a scientific advisory committee. From the initial discussions, a structured questionnaire was developed for use with a group of specialists on OA using the Delphi technique. The questionnaire was sent to 21 experts appointed by the authors, and the results obtained were critically analyzed and validated. RESULTS: The prevalence of OA was 33% in Brazil, corresponding to one-third of the individuals in the reference population, which included individuals over 25 years of age. Another significant finding was that most patients did not receive any form of treatment in the early stages of OA. CONCLUSION: The committee pointed to the need for early intervention and that the available medicinal resources can fulfil this important role, as is the case with SYSADOA treatments. Glucosamine-based medicinal products with or without chondroitin could also fulfill this need for early treatment. The other generated evidence and included investigations were then grouped together and are the subject of this publication.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Osteoarthritis/therapy , Delphi Technique , Clinical Competence/standards , Evidence-Based Medicine/standards , Orthopedics/standards , Osteoarthritis/drug therapy , Physical and Rehabilitation Medicine/standards , Severity of Illness Index , Brazil , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Chondroitin Sulfates/therapeutic use , Treatment Outcome , Osteoarthritis, Knee/therapy , Consensus , Drug Therapy, Combination , Glucosamine/therapeutic use
17.
ABCS health sci ; 43(1): 55-60, maio 18, 2018. ilus, tab
Article in Portuguese | LILACS | ID: biblio-884002

ABSTRACT

A osteoartrite é uma doença que pode interferir no equilíbrio postural por meio de alterações neuromusculares diversas e a fisioterapia possui meios que buscam a manutenção ou reabilitação deste problema. O objetivo desta revisão foi identificar, na literatura, meios reabilitativos sobre o equilíbrio postural de indivíduos com osteoartrite. Realizou-se uma revisão sistemática nas bases de dados SciELO, Medline e LILACS, entre os meses de janeiro à março de 2016, a partir do descritor primário "Osteoartrite" (Osteoarthritis) em cruzamento com os descritores secundários "Equilíbrio Postural" (Postural Balance), "Fisioterapia" (Physical Therapy Specialty) e "Reabilitação" (Rehabilitation), nas línguas portuguesa e inglesa. Inicialmente encontraram-se 275, dos quais 29 foram recrutados para uma análise qualitativa criteriosa. Ao fim, quatro artigos foram eleitos mediante os critérios estabelecidos pela revisão: um artigo abordou a cinesioterapia em solo, dois a hidrocinesioterapia e um a prática de exercícios domiciliares. Conclui-se que a manutenção ou reabilitação do equilíbrio postural, tanto estático quanto dinâmico, constitui um fenômeno de grande complexidade nos indivíduos acometidos pela osteoartrite. As técnicas fisioterapêuticas abordadas (cinesioterapia em solo, hidrocinesioterapia e a prática de exercícios físicos domiciliares) demonstraram efeitos positivos no manejo do equilíbrio postural em indivíduos com osteoartrite de quadril ou de joelho.


Osteoarthritis is a disease that can interfere with postural balance through various neuromuscular changes and physiotherapy has means that seek to maintain or rehabilitate this problem. The objective of this review was to identify, in the literature, rehabilitative means on the postural balance of individuals with osteoarthritis. A systematic review was performed between the months of January and March 2016 in the databases SciElo, Medline and LILACS, from the primary descriptor "Osteoartrite" (Osteoarthritis) in junction with the secondary keywords "Equilíbrio Postural" (Postural Balance), "Fisioterapia" (Physical Therapy Specialty) and "Reabilitação" (Rehabilitation) in Portuguese and English. Initially, 275 were found, of whom 29 were recruited for a qualitative analysis. Finally, four articles were chosen according to the criteria established by the review: one article addressed kinesiotherapy in soil, two to hydrokinesiotherapy and one to practice home exercises. It is concluded that the maintenance or rehabilitation of postural balance, both static and dynamic, is a phenomenon of great complexity in the individuals affected by osteoarthritis. The physiotherapeutic techniques (soil kinesiotherapy, hydrokinesiotherapy and physical exercises at home) showed positive effects on the management of postural balance in individuals with hip or knee osteoarthritis.


Subject(s)
Humans , Osteoarthritis/therapy , Rehabilitation , Physical Therapy Modalities , Postural Balance
18.
Rev. chil. reumatol ; 34(3): 122-127, 2018.
Article in Spanish | LILACS | ID: biblio-1254233

ABSTRACT

El manejo del dolor articular ofrece para la población afectada novedosos suplementos nutricionales que incluyen el colágeno, y cuya extracción es desde variadas fuentes de origen animal, no así de vegetales. Esta revisión tiene como objetivo aclarar qué es el colágeno, su constitución estructural molecular, el rol que cumple en nues-tro organismo y revisar las indicaciones propuestas por la literatura, tanto para la profilaxis como el tratamiento de cuadros reumatológicos de alta prevalencia o impacto funcional, como son Artrosis, Artritis Reumatoidea y Osteoporosis.


Novel nutritional supplements for the management of joint pain have been made available to the population, including collagen, which can not be extracted from plant products, but from a variety of animal sources. This review aims to clarify what it is collagen, the molecular structures that constitute it, the determined role they play in our body and review the indications that the literature proposes both in prophylaxis and treatment, for high prevalence rheumatologic or functional impact, such as osteoarthritis, rheumatoid arthritis and osteoporosis.


Subject(s)
Humans , Rheumatic Diseases/therapy , Collagen/therapeutic use , Osteoarthritis/therapy , Osteoporosis/therapy , Arthritis, Rheumatoid/therapy , Extracellular Matrix
19.
Medwave ; 18(3): e7216, 2018.
Article in English, Spanish | LILACS | ID: biblio-911673

ABSTRACT

INTRODUCCIÓN: El manejo no quirúrgico de la artrosis es variado y los pacientes que la padecen muchas veces persisten sintomáticos a pesar de intentar múltiples alternativas no quirúrgicas. En la última década, se ha planteado el uso de plasma rico en plaquetas intraarticular como alternativa, sin embargo, existe controversia sobre su eficacia clínica y seguridad. MÉTODOS: Para responder esta pregunta utilizamos Epistemonikos, la mayor base de datos de revisiones sistemáticas en salud, la cual es mantenida mediante búsquedas en múltiples fuentes de información, incluyendo MEDLINE, EMBASE, Cochrane, entre otras. Extrajimos los datos desde las revisiones identificadas, reanalizamos los datos de los estudios primarios, realizamos un metanálisis y preparamos una tabla de resumen de los resultados utilizando el método GRADE. RESULTADOS Y CONCLUSIONES: Identificamos doce revisiones sistemáticas que en conjunto incluyen cuatro estudios primarios, correspondientes a ensayos aleatorizados. Concluimos que la inyección intraarticular de plasma rico en plaquetas podría disminuir levemente el dolor articular, podría mejora la satisfacción del paciente, y no está claro si tiene algún efecto sobre la funcionalidad porque la certeza de la evidencia es muy baja. En cuanto a los efectos adversos, de existir, serían no severos y autolimitados.


INTRODUCTION: Despite varied non-surgical alternatives for the treatment of osteoarthritis, many patients remain symptomatic. In the last decade, the use of intra-articular platelet-rich plasma (PRP) has been proposed as an option. However, there is controversy about its clinical benefit and safety. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. CONCLUSIONS: We identified twelve systematic reviews including four studies overall, of which all corresponded to randomized trials. We concluded that intra-articular injection of platelet-rich plasma might slightly decrease joint pain and improve patient satisfaction,vut it is not clear whether it has any effect on functionality because the certainty of the evidence is very low. As for the adverse effects, if they exist, they would be non-severe and self-limited.


Subject(s)
Humans , Osteoarthritis/therapy , Platelet-Rich Plasma , Randomized Controlled Trials as Topic , Databases, Factual , Treatment Outcome , Injections, Intra-Articular
20.
Medisan ; 21(2)feb. 2017. tab
Article in Spanish | LILACS | ID: biblio-841652

ABSTRACT

Se realizó una intervención terapéutica en 118 pacientes con artrosis cervical, atendidos en el Servicio de Rehabilitación Integral del Hospital Clinicoquirúrgico Docente Dr Joaquín Castillo Duany de Santiago de Cuba, desde julio de 2013 hasta diciembre de 2014, para evaluar la efectividad de la reflexología podal como modalidad de tratamiento. La muestra fue dividida en 2 grupos (de estudio y control), de 54 integrantes cada uno, pareados por edad y sexo. En ambos grupos, el mayor número de afectados superó los 50 años de edad; asimismo, poco más de dos tercios de los individuos seleccionados mejoraron a los 7 días de evolución y en tan solo 3 sesiones de tratamiento, hasta la resolución definitiva a los 21 días (9 sesiones). Se registró una reacción adversa y se concluyó que esta terapia garantiza una mejoría significativa de los síntomas, de ahí su elevada efectividad, sin consumo excesivo de tiempo


A therapeutic intervention in 118 patients with cervical osteoarthritis was carried out. They were assisted in the Comprehensive Rehabilitation Service of Dr Joaquín Castillo Duany Teaching Clinical Surgical Hospital in Santiago de Cuba, from July, 2013 to December, 2014, to evaluate the effectiveness of podal reflexology as a treatment modality. The sample was divided in 2 groups (study group and control group), of 54 members each, paired by age and sex. In both groups, the highest number of affected patients were over 50 years; also, a little more than two thirds of the selected individuals improved at 7 days of the clinical course and with only 3 treatment sessions, until the definitive resolution at 21 days (9 sessions). An adverse effect was registered and it was concluded that this therapy guarantees a significant improvement of symptoms, so its high effectiveness, without excessive consumption of time


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Osteoarthritis/therapy , Complementary Therapies , Joint Diseases/therapy , Massage , Secondary Care , Evaluation of Results of Therapeutic Interventions , Evaluation of the Efficacy-Effectiveness of Interventions
SELECTION OF CITATIONS
SEARCH DETAIL