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1.
ABCS health sci ; 46: e021224, 09 fev. 2021. ilus, tab
Article in English | LILACS | ID: biblio-1349379

ABSTRACT

INTRODUCTION: Perineal trauma is an important complication for women after giving birth. OBJECTIVE: To evaluate the prevalence of perineal trauma and its associated factors in nulliparous. METHODS: A retrospective cohort study was carried out, through the analysis of the medical records of women with singleton pregnancy who achieved vaginal birth of a live infant, in 2017, in a maternity hospital. Data collection involved information about demographic, obstetric, and clinical data from nulliparous women, and infant birthweight. Univariate and multivariate logistic analyses were performed to verify the association of perineal trauma with the variables assessed, with significant variables remaining in the model (p<0.05), through a stepwise strategy. RESULTS: A total of 326 medical records were analyzed. The percentage of perineal trauma was 60%. In the multivariate analysis, the use of oxytocin increased the chance of perineal trauma by 730%. In addition, the adoption of squatting position and hands and knees decreased the chances of perineal trauma by 81% and 97%, respectively, in comparison with those who adopted the lithotomy position, during the second stage labor. CONCLUSION: The rate of perineal laceration was high, but the severity was low. The use of oxytocin is associated with the presence of trauma and the squatting position and hands and knees, especially, have contributed to the protection of the perineum.


INTRODUÇÃO: Laceração perineal é uma complicação importante para mulheres pós-parto. OBJETIVO: Avaliar a prevalência de laceração perineal e seus fatores associados em primíparas. MÉTODOS: Foi realizado um estudo de coorte retrospectivo, através da análise dos prontuários de mulheres que pariram no ano de 2017, em uma maternidade da cidade. Durante a coleta de dados foi utilizada uma lista de checagem e um formulário para retirar informações sobre dados obstétricos, sociodemográficos e clínicos das mulheres e o peso do recém-nascido. Em seguida foram formuladas tabelas para determinação da associação entre as variáveis independentes e a presença de laceração. Logo após, foi feita a análise de regressão logística múltipla para identificar as variáveis mais fortemente associadas à laceração perineal. RESULTADOS: Um total de 326 prontuários foram analisados. O percentual de laceração perineal foi de 60%. Na análise multivariada, o uso de oxitocina aumentou a chance de laceração perineal em 730%. Além disso, a posição de cócoras e de quatro apoios diminuíram a chance de laceração perineal em 80% e 97%, respectivamente, em comparação com as mulheres que adotaram a posição de litotomia, durante o segundo período do parto. CONCLUSÃO: A taxa de laceração perineal encontrada foi alta, mas a gravidade foi baixa. O uso de ocitocina está associado com a presença de laceração perineal e a posição de cócoras e de quatro apoios contribuem para a proteção do períneo.


Subject(s)
Humans , Female , Pregnancy , Adolescent , Adult , Young Adult , Perineum/injuries , Puerperal Disorders , Women's Health , Parturition , Parity , Oxytocin , Episiotomy
2.
Rev. Bras. Saúde Mater. Infant. (Online) ; 20(4): 1081-1090, Oct-Dec. 2020. tab
Article in English | LILACS | ID: biblio-1155291

ABSTRACT

Abstract Objectives: to identify the prevalence and factors associated with obstetric interventions in parturients assisted in public maternity hospitals. Methods: a cross-sectional study with 344 puerperal women, from two public maternity hospitals, referring to childbirth by Sistema Único de Saúde (SUS) (Public Health Service System) in Londrina City, Paraná, Brazil, between January and June 2017. The medical records were the data source. The following obstetric interventions were considered: oxytocin use, artificial rupture of the membranes, instrumental childbirth and episiotomy. Multivariate Poisson regression was used to analyze associated factors, with p<5% being significant. Results: the prevalence of obstetric intervention was 55.5%, the maximum number of interventions in the same parturient woman was three. The most frequent interventions were the use of oxytocin (50.0%) and artificial rupture of membranes (29.7%). The variables associated on maternal disease (p=0.005) and intrapartum meconium (p=0.022) independently increased, the risk of obstetric intervention, while dilation was equal to or greater than 5 cm at admission, there was a protective factor against this outcome (p=0.030). Conclusion: the prevalence of obstetric interventions was high. In the case of maternal disease and intrapartum meconium, special attention should be given to the parturient woman, in order to avoid unnecessary interventions. Thus, the maternity hospitals need to review their protocols, seeking good practices in childbirth care.


Resumo Objetivos: identificar a prevalência e os fatores associados a intervenções obstétricas em parturientes atendidas em maternidades públicas. Métodos: estudo transversal, com 344 puérperas, de duas maternidades públicas, referência ao parto pelo Sistema Único de Saúde no município de Londrina, Paraná, Brasil, entre janeiro e junho de 2017. Constituíram fonte de dados os prontuários hospitalares. As seguintes intervenções obstétricas foram consideradas: uso de ocitocina, rotura artificial das membranas, parto instrumental e realização de episiotomia. Para análise dos fatores associados utilizou-se a regressão multivariada de Poisson, sendo significativo p<5%. Resultados: a prevalência de intervenção obstétrica foi de 55,5%, o número máximo de intervenções em uma mesma parturiente foi três. As intervenções mais frequentes foram o uso de ocitocina (50,0%) e a rotura artificial das membranas (29,7%). As variáveis doença materna associada (p=0,005) e mecônio intraparto (p=0,022) aumentaram, de maneira independente, o risco de intervenção obstétrica, enquanto que a dilatação igual ou superior a 5 cm na internação constituiu fator de proteção a esse desfecho (p= 0,030). Conclusão: a prevalência de intervenções obstétricas foi elevada. Na vigência de doença materna e de mecônio intraparto, especial atenção deve ser dedicada à parturiente, para que sejam evitadas intervenções desnecessárias, assim as maternidades precisam rever seus protocolos, buscando as boas práticas de atenção ao parto.


Subject(s)
Humans , Female , Pregnancy , Labor, Obstetric , Risk Factors , Medicalization , Midwifery , Natural Childbirth/statistics & numerical data , Prenatal Care , Brazil , Oxytocin , Poisson Distribution , Cross-Sectional Studies , Episiotomy , Amniotomy , Hospitals, Maternity
3.
Rev. chil. obstet. ginecol. (En línea) ; 85(supl.1): S28-S34, set. 2020. tab
Article in Spanish | LILACS | ID: biblio-1138646

ABSTRACT

INTRODUCCIÖN Y OBJETIVOS: Describir la experiencia de los partos en gestantes con diagnóstico confirmado de COVID 19 mediante RT-PCR asintomáticas o con sintomatología leve y aquellas sin la enfermedad, y determinar la tasa de éxito de parto vaginal en inducción de trabajo de parto. MÉTODOS: Análisis retrospectivo de pacientes que tuvieron su parto entre 15 de Abril y 03 de Julio del 2020 en el Hospital San Juan de Dios. Se incluyeron las pacientes inducidas con Dinoprostona, Oxitocina o ambas de manera secuencial y se dividieron según estatus COVID 19 mediante RT-PCR al ingreso. Se caracterizó demográficamente el grupo de pacientes positivas y se determinaron los datos de ambos grupos en relación a la necesidad de inducción de trabajo de parto y su éxito para parto vaginal. RESULTADOS: De un total de 657 nacimientos, hubo un 9.7% (n=64) de pacientes con COVID 19, de las cuales un 23.4% (n=15) requirió inducción de trabajo de parto, con una tasa de éxito para parto vaginal de un 66.7% (n=10). De estas pacientes, un 50% recibió Oxitocina, un 40% Dinosprostona y un 10% ambos medicamentos de forma secuencial. En las pacientes negativas, hubo un total de 568 nacimientos, con un 29.8% (n=169) de usuarias que requirieron inducción. La tasa de éxito para parto vaginal en este grupo fue de 72.2% (n=122), utilizando un 50% Oxitocina; un 27% Dinoprostona; un 14.8% ambas; y un 8.2% Balón de Cook. CONCLUSIONES: Sabemos que los resultados de este estudio están limitados por el bajo número de pacientes incluidas, sin embargo, podemos observar que, en nuestra experiencia con las pacientes que arrojaron PCR SARS-CoV-2 positivas, asintomáticas o con enfermedad leve, se logró realizar la inducción de trabajo de parto según protocolos habituales, obteniendo porcentajes de éxito para partos vaginales, similares a las pacientes sin la enfermedad.


INTRODUCTION AND OBJECTIVES: Describe the experience of deliveries in pregnant women with a confirmed diagnosis of COVID 19 by asymptomatic RT-PCR or with mild symptoms and those without the disease, and determine the success rate of vaginal delivery in the induction of labor. METHODS: Retrospective study of patients who had their delivery between 15th April and 03rd of July, 2020 in the San Juan de Dios Hospital. Patients induced with Dinoprostone, Oxytocin or both sequentially were included, and were divided according to COVID 19 status by RT-PCR on their admission process. The group of positive patients was demographically characterized and the data of both groups was determined in relation to the need for labor induction and its success for vaginal delivery. RESULTS: Of a total of 657 births, there were 9.7% (n = 64) of patients with COVID 19, of which 23.4% (n = 15) required labor induction, with a success rate for vaginal delivery of 66.7% (n = 10). Of these patients, 50% received Oxytocin, 40% Dinosprostone and 10% both drugs sequentially. In the negative patients, there were a total of 568 births, with 29.8% (n = 169) of users requiring labor induction. The success rate for vaginal delivery in this group was 72.2% (n = 122); 50% using Oxytocin; 27% Dinoprostone; 14.8% using both; and 8.2% using Cook's Catheter. CONCLUSIONS: We know that the results of this study are limited by the low number of patients included, however, in our experience, we can observe that, in patients with SARS-CoV-2 PCR positive, asymptomatic or with mild disease, it was possible to perform induction of labor according to standard protocols, achieving success rates for vaginal deliveries, similar to patients without the disease.


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Adolescent , Adult , Middle Aged , Young Adult , Pneumonia, Viral/complications , Pregnancy Complications, Infectious/therapy , Pregnancy Complications, Infectious/virology , Coronavirus Infections/complications , Labor, Induced/methods , Oxytocin/administration & dosage , Pregnancy Outcome , Dinoprostone/administration & dosage , Cesarean Section , Retrospective Studies , Delivery, Obstetric , Pandemics , Betacoronavirus
4.
San Salvador; MINSAL; sept.16, 2020. 12 p. ilus, graf.
Non-conventional in Spanish | LILACS, BIGG, BISSAL | ID: biblio-1121036

ABSTRACT

La presente guía se elaboró siguiendo los lineamientos del Manual para la elaboración de guías de la Organización Mundial de la Salud. De forma general, se creó un grupo desarrollador multidisciplinario, compuesto por expertos temáticos, epidemiólogos, metodólogos y pacientes. Con base en la evidencia proveniente de la guía para el uso de uterotónicos para la prevención de hemorragia posparto, se desarrolló una adaptación para el contexto del Sistema Nacional Integrado de Salud de El Salvador. Se incluyó de evidencia local y la contextualización de sus recomendaciones. Las recomendaciones fueron graduadas en un panel de expertos conformado por profesionales en estadística, enfermería, materno infantil y médicos generales y especialistas en las siguientes áreas: ginecología y obstetricia, perinatología, anestesiología, medicina familiar, economía de la salud, epidemiología, además se incluyó la participación de pacientes siguiendo el enfoque Grading of Recommendations, Assessment, Development and Evaluation (GRADE)


This guide was prepared following the guidelines of the Manual for the preparation of guidelines of the World Health Organization. In general, a multidisciplinary development group was created, composed of thematic experts, epidemiologists, methodologists, and patients. Based on the evidence from the guide for the use of uterotonics for the prevention of postpartum hemorrhage, an adaptation was developed for the context of the National Integrated Health System of El Salvador. Local evidence and the contextualization of their recommendations were included. The recommendations were graded by a panel of experts made up of professionals in statistics, nursing, maternal and child health, and general practitioners and specialists in the following areas: gynecology and obstetrics, perinatology, anesthesiology, family medicine, health economics, epidemiology, and it was also included patient participation following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE)


Subject(s)
Pregnancy , Oxytocics/therapeutic use , Postpartum Hemorrhage/prevention & control , Postpartum Hemorrhage/drug therapy , Postpartum Hemorrhage/therapy , Oxytocin/therapeutic use , Misoprostol/therapeutic use
5.
Actual. osteol ; 16(2): [132]-[140], mayo.-ago. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1129806

ABSTRACT

La oxitocina (OXT) como la arginina-vasopresina (AVP) son dos hormonas primitivas secretadas por la hipófisis posterior. Sus receptores están mucho más ampliamente distribuidos en el organismo de lo que se pensaba originalmente, incluido el hueso. En los estudios preclínicos, la OXT ha mostrado ser anabólica para el hueso, promoviendo la osteogénesis sobre la adipogénesis y favoreciendo la actividad osteoblástica sobre la osteoclástica. Tanto los osteoblastos como los osteoclastos tienen receptores para la OXT, y los efectos de los estrógenos sobre la masa ósea en ratones está mediada por lo menos en parte por la OXT. El mecanismo preciso por el cual la activación de los receptores de oxitocina (OXTR) se traduce en un incremento de la formación ósea permanece poco claro. La AVP también podría afectar el esqueleto en forma directa. Dos de los receptores de la AVP, V1a y V2 están expresados en osteoblastos y osteoclastos. La inyección de AVP en ratones de tipo salvaje aumenta la formación osteoclastos que producen resorción y reduce los osteoblastos formadores de hueso. En forma opuesta, la exposición de precursores osteoblásticos a antagonistas de los receptores V1a o V2, incrementan la osteoblastogénesis, como también lo hace la deleción genética del receptor V1a. (AU)


Both oxytocin (OXT) and argininevasopressin (AVP) are primitive hormones secreted by the posterior pituitary gland. OXT receptors are much more widely distributed in the body than originally thought, including in bone. In preclinical studies, OXT has been shown to be anabolic for bone, promoting osteogenesis over adipogenesis and favoring osteoblastic over osteoclastic activity. Both osteoblasts and osteoclasts have receptors for OXT, and the effects of estrogen on bone mass in mice is mediated at least in part by OXT. The precise mechanism by which the activation of oxytocin receptors (OXTRs) results in an increase in bone formation remains unclear. AVP could also have direct actions on the skeleton. The two AVP receptors, V1a and V2, are expressed in osteoblasts and osteoclasts. Injection of AVP in wild-type mice increases the formation of osteoclasts increasing bone resorption, and reduces bone-forming osteoblasts. On the contrary, the exposure of osteoblastic precursors to V1a and V2 antagonists increase osteoblastogenesis, the same as the genetic deletion of the V1a receptor. (AU)


Subject(s)
Humans , Animals , Mice , Pituitary Hormones, Posterior/biosynthesis , Arginine Vasopressin/adverse effects , Oxytocin/therapeutic use , Osteoblasts/physiology , Osteoclasts/physiology , Osteogenesis , Osteoporosis/therapy , Pituitary Hormones, Posterior/physiology , Arginine Vasopressin/antagonists & inhibitors , Arginine Vasopressin/biosynthesis , Arginine Vasopressin/physiology , Arginine Vasopressin/therapeutic use , Oxytocin/biosynthesis , Oxytocin/adverse effects , Oxytocin/physiology , Signal Transduction , Bone Density , Bone Density/drug effects , Receptors, Oxytocin/biosynthesis , Receptors, Oxytocin/physiology , Estradiol/therapeutic use , Estrogens/physiology
6.
Interface (Botucatu, Online) ; 24: e180390, 2020.
Article in Portuguese | LILACS | ID: biblio-1056566

ABSTRACT

O Brasil é o campeão mundial no número de cesáreas, em especial no setor privado de saúde. Este número pode chegar a mais de 80% entre gestantes das classes média e alta em algumas regiões do país. Contrapondo-se a isso, o movimento do parto humanizado vem ganhando força, tendo como objetivos a denúncia da violência obstétrica e o retorno da a forma natural de parturição e cuidado com o bebê. Neste artigo, pretendemos discutir o modo como o ideário desse movimento implica na constituição de um novo sentido à maternidade a partir de uma concepção de natureza corporal e o papel da ocitocina nesse processo.(AU)


Brazil is the world champion in number of cesarean sections, especially in the private health sector. This figure can reach more than 80% among middle and upper class pregnant women in some regions of the country. Opposing this situation, the "humanized birth" movement has been gaining ground. Its objectives are the denouncement of "obstetric violence" and the return to a "natural" form of parturition and childbirth care. In this article we aim to discuss the way in which the ideas of this movement imply the constitution of a new meaning for maternity based on a conception of bodily nature, and the role played by oxytocin in this process.(AU)


Brasil es el campeón mundial en el número de cesáreas, en especial en el sector privado de la salud. este número puede llegar a más del 80% entre gestantes de clases medias y altas en algunas regiones del país. En contraposición a este estado de cosas, el movimiento del "parto humanizado" ha adquirido fuerza, teniendo como objetivos la denuncia de "violencia obstétrica" y el retorno de una forma "natural" de parto y cuidado del bebé. En este artículo pretendemos discutir la forma como el ideario de este movimiento implica en la constitución de un nuevo sentido para la maternidad a partir de una concepción de naturaleza corporal y el papel de la oxitocina en ese proceso.(AU)


Subject(s)
Humans , Female , Oxytocin/physiology , Parenting/trends , Humanizing Delivery , Gender-Based Violence
7.
Einstein (Säo Paulo) ; 18: eAO5029, 2020. tab
Article in English | LILACS | ID: biblio-1039733

ABSTRACT

ABSTRACT Objective To characterize the use of the drug misoprostol for treatment of postpartum hemorrhage in pregnant women. Methods A descriptive observational study was carried out with secondary data from pregnant women who used misoprostol to treat postpartum hemorrhage in a reference public maternity, from July 2015 to June 2017. Clinical and sociodemographic profiles of pregnant women, how misoprostol was used and success rate in controling postpartum hemorrhage were characterized. Results A total of 717 prescriptions of misoprostol were identified. Of these, 10% were for treatment of postpartum hemorrhage. The majority of pregnant women were young adults, married, with complete high school education, white, residing in urban areas, multiparous (68.1%) and 25% had previous cesarean sections. The mean gestational age was 39 weeks and 51.4% had a cesarean section. There was prophylactic use of oxytocin in 47.2% of women. Treatment of postpartum hemorrhage was successful in 84.7% of women. Of these, 79.2% also used oxytocin and 54.2% methylergonovine. Only 13.5% of pregnant women had less than five prenatal visits, and the main cause of postpartum hemorrhage was uterine atony. There were 13 complications after hemorrhage, 15.3% required blood transfusion and there was one case of maternal death. Conclusion Misoprostol showed to be effective and safe for treating postpartum hemorrhage.


RESUMO Objetivo Caracterizar o uso do medicamento misoprostol para o tratamento da hemorragia pós-parto em gestantes. Métodos Estudo observacional descritivo realizado por meio de dados secundários de gestantes que fizeram uso do misoprostol para tratamento da hemorragia pós-parto em maternidade pública de referência, no período de julho de 2015 a junho de 2017. Caracterizaram-se os perfis clínico e sociodemográfico das gestantes, o padrão de utilização do misoprostol e sua taxa de sucesso no controle da hemorragia pós-parto. Resultados Foram identificadas 717 prescrições do misoprostol. Destas, 10% foram para tratamento da hemorragia pós-parto. Predominaram gestantes adultas jovens, casadas, com Ensino Médio completo, raça branca, da região urbana, multíparas (68,1%) e 25% apresentavam cesáreas prévias. A idade gestacional média foi 39 semanas e 51,4% das gestantes tiveram parto cesárea. Houve uso profilático de ocitocina em 47,2% das mulheres. O tratamento da hemorragia pós-parto eve sucesso em 84,7% das gestantes que usaram misoprostol. Destas, 79,2% também usaram ocitocina e 54,2% metilergometrina. Apenas 13,5% das gestantes tiveram menos de cinco consultas de pré-natal, e a principal causa da hemorragia pós-parto foi atonia uterina. Foram registrados 13 casos de complicações após a hemorragia, 15,3% necessitaram de hemotransfusão e houve um caso de óbito materno. Conclusão O misoprostol demonstrou ser efetivo e seguro para o tratamento da hemorragia pós-parto.


Subject(s)
Humans , Pregnancy , Adult , Young Adult , Oxytocics/therapeutic use , Misoprostol/therapeutic use , Postpartum Hemorrhage/drug therapy , Oxytocin/therapeutic use , Cross-Sectional Studies , Gestational Age , Methylergonovine/therapeutic use
8.
Psico (Porto Alegre) ; 51(2): 30291, 2020.
Article in English | LILACS | ID: biblio-1123422

ABSTRACT

Context: The term "Well-being" [WB] has many different meanings in scientific literature. Objectives: To search specific situations and related semantics for feelings of well-being [WB] associated to oxytocin [OT] release. Data sources: A systematic review using PRISMA guidelines in PubMed, BVS Virtual (Medline, Lilacs) and SIBI-USP Portal de Busca Integrada (1970-1999 & 2014-2018). Study selection: Reviews and clinical trials (PICOS) on OT, & WB and similar concepts in humans. Data extraction: Independent selection of articles by two reviewers; selection of articles by one reviewer, using predefined criteria. Data synthesis: 46 articles were selected out of 339, with 26 additional articles. Main data referred to social situations, sensorial stimuli, trust and psychiatric and health studies. Conclusions: The identified variables involved brain-body-mind interactions, and health/disease; translational neuroscience seems to be the best theoretical reference to investigate it.


Contexto: O termo "Bem-estar" [WB] apresenta muitos significados diferentes na literatura. Objetivos: Buscar situações específicas e semânticas relacionadas a sentimentos de bem-estar [WB] ligados à ocitocina [OT]. Fontes de dados: Revisão sistemática a partir das Referências PRISMA nas bases de dados PubMed, BVS Virtual (Medline, Lilacs) and SIBI-USP Portal de Busca Integrada (1970-1999 & 2014-2018). Seleção do estudo: revisões e ensaios clínicos (PICOS) sobre OT, & WB e sinônimos, em humanos. Extração de dados: seleção independente de artigos por dois revisores. Um revisor selecionou os textos utilizando critérios pré-definidos. Síntese dos dados: Dentre 339 artigos, 46 foram selecionados, e mais 26 posteriormente adicionados. Os principais dados obtidos referiam-se a situações sociais, estímulos sensoriais, confiança e estudos psiquiátricos e de saúde. Conclusões: As variáveis identificadas envolveram interações cérebro-corpo-mente e saúde; A neurociência translacional parece ser o melhor referencial teórico para investigá-la.


Contexto: El termo "Bienestar" [WB] abarca muchos significados diferentes en la literatura científica. Objetivos: buscar situaciones y semánticas sobre sentimientos de bienestar [WB] asociados con la produccion de oxitocina [OT]. Fuentes de datos: Revisión sistemática en PubMed, BVS Virtual (Medline, Lilacs) y SIBI-USP Portal de Busca Integrada (1970-1999; 2014-2018). Selección de estudios: revisiones y ensayos clínicos (PICOS) en OT, & WB y sinónimos, en humanos. Extracción de datos: Extracion independiente de artículos por dos revisores; selección de artículos por un revisor, utilizando criterios predefinidos. Síntesis de datos: se seleccionaron 46 artículos dentre 339, y mas 26 adicionales. Los datos principales se referían a situaciones sociales, estímulos sensoriales, confianza y estudios psiquiátricos y de salud. Conclusiones: Las variables identificadas involucraron interacciones cerebro-cuerpo-mente y salud; La neurociencia traslacional parece ser el mejor marco teórico para investigarlo.


Subject(s)
Humans , Oxytocin/physiology , Happiness , Homeostasis/physiology , Psychophysiology
9.
Article in English | WPRIM | ID: wpr-876621

ABSTRACT

@#Background: Acupressure may stimulate oxytocin release from the pituitary gland, which in turn regulates uterine contractions to improve the progress of labor; hence, studies have shown that acupressure on the Spleen 6 (SP6) point may be a complementary strategy for augmenting labor and/or shortening the first stage of labor without causing adverse effects to the mother or the newborn. Objective: To compare contractions produced by acupuncture technique from the contractions produced by conventional method using oxytocin in terms of: intensity, duration and interval of the uterine contractions and to determine if acupuncture technique at Sanyinjiao (spleen 6) and Hegu (Large Intestine 4) can be used as alternative method in establishing uterine contractions in Contraction Stress Test (CST) as a means of fetal surveillance. Methodology: This is a Randomized Controlled Trial done in University of Santo Tomas Hospital. This included 54 term pregnant patients who met the inclusion criteria and were randomized into two groups: 27 patients in Acupuncture group and 27 patients in Oxytocin group (control group). All recruited patients were hooked to electronic fetal monitor to obtain baseline strips for 20 minutes. Acupuncture needles were applied bilaterally at Sanyinjiao (spleen 6) and Hegu (Large Intestine 4) for 20 minutes to the study subjects. Results: Subjects who received acupuncture had greater intensity (p=0.551) and significant longer duration (p=0.001) of uterine contractions than the oxytocin group. However, there was significant shorter interval of uterine contractions after oxytocin treatment (p=0.013) than acupuncture. Furthermore, subjects who were in the acupuncture group obtained initial uterine contractions and achieved desirable uterine contractions faster than oxytocin. Conclusion: Application of acupuncture in Spleen 6 (Sanyinjiao SP6) and Large Intestine 4 (Hegu LI4) can initiate and induce uterine contractions faster. Acupuncture technique when compared to the conventional method using oxytocin, produces stronger and longer contractions. Furthermore, there is shorter mean time to achieve initial and adequate contractions thru acupuncture technique. Contractions also disappear in a much shorter time in acupuncture technique than in oxytocin group hence ideal for outpatient setting.


Subject(s)
Pregnancy , Female , Uterine Contraction , Oxytocin , Acupuncture Therapy
10.
Article in English | WPRIM | ID: wpr-876619

ABSTRACT

@#Background: A prolonged interval from prelabor rupture of membranes to delivery is associated with an increase in the incidence of maternal and neonatal morbidities and mortality. Various agents have been tested to improve the cervical Bishop score to expedite the delivery of the fetus and lessen the maternal and neonatal complications. Objective: To compare two protocols for labor induction in pregnant women with prelabor rupture of membranes (PROM). Population: Subjects were recruited from the University of Santo Tomas Hospital (Private Division and Clinical Division). Pregnant women with a live, term, singleton fetus, cephalic presentation, a reactive Non stress test, who presented with PROM and a Bishop score of ?5, with no previous Cesarean section, or other uterine surgery. Methodology: This is a two-arm superiority, open label, randomized controlled trial. Pregnant women with a live, term, singleton fetus, cephalic presentation, a reactive Non stress test, who presented with PROM and a Bishop score of ?5, and with no previous Cesarean section or other uterine surgery were randomly assigned to receive either intravenous (IV) oxytocin infusion or intracervical dinoprostone 0.5 mg gel followed 6 hours later by IV oxytocin infusion. Results: Vaginal delivery within 24 hours of labor induction increased significantly with intracervical dinoprostone gel followed by IV oxytocin infusion (87% versus 61%; RR: 1.43; 95% CI: 0.99 – 2.06; P<0.044). Comparable result was observed for nulliparous women included in the study population. The time interval from labor induction to active phase was significantly shorter in the dinoprostone-oxytocin group than in the oxytocin alone group (2.4 ± 2.1 versus 6.3 ± 1.4 hours; p<0.001). The time interval from labor induction to delivery was also significantly shorter in the dinoprostoneoxytocin group (6.3 ± 1.5 versus 10.4 ± 1.4 hours; p<0.000). Cesarean delivery rates were statistically similar in the dinoprostone-oxytocin and oxytocin alone groups (17% versus 40%; p=0.102). The neonatal outcomes were comparable in both groups, except for birth weight. Conclusion: Intracervical dinoprostone 0.5 mg gel followed 6 hours later by an oxytocin infusion in term women presenting with PROM and an unfavorable cervix (Bishop Score of 5 or less) was associated with a higher rate of vaginal delivery within 24 hours, shorter time interval from labor induction to active phase of labor, and shorter time interval from labor induction to delivery, and no difference in maternal and neonatal complications was observed compared with oxytocin infusion alone.


Subject(s)
Dinoprostone , Oxytocin , Labor, Obstetric
11.
Rev. chil. obstet. ginecol. (En línea) ; 84(3): 196-207, jun. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1020637

ABSTRACT

RESUMEN Una complicación frecuente del postparto es la depresión, con una prevalencia del 10 al 20% a nivel mundial. La oxitocina ha sido reconocida como un potente neuromodulador presente en la respuesta materna y la vinculación con su recién nacido. El uso de oxitocina sintética intraparto es una práctica frecuente. Objetivo: Relacionar la exposición a oxitocina sintética intraparto con el riesgo de depresión postparto en mujeres atendidas en un hospital público del sur de Chile, durante los años 2014-2015. Material y método: Estudio cuantitativo de cohorte, analítico, prospectivo. Muestreo no probabilístico, consecutivo a 58 mujeres desde el último trimestre de la gestación hasta las doce semanas postparto, midiendo el riesgo de depresión mediante la escala de Edimburgo. Se relacionaron variables bio-psicosociales y perinatales, con un nivel de significación <0,05. Aprobado por comité de ética. Resultados: La edad promedio fue 26,07 años, la mayoría había cursado enseñanza media, desempeñándose en quehaceres domésticos, con atención sanitaria gratuita y poseían una percepción de buen apoyo social. En los aspectos perinatales el 63,7 % se expusieron a oxitocina sintética. El riesgo de depresión se observó en un 12,07%. Las dosis y tiempo de exposición, al igual que el tipo de parto no resultaron estadísticamente significativos para el riesgo de depresión. Factores protectores y de riesgo psicosociales como perinatales, tampoco demostraron diferencias. Conclusiones: En este grupo, no se encontró asociación estadística entre la exposición a oxitocina intraparto con la sintomatología de depresión en el periodo de posparto, medida a través de la escala de Edimburgo.


ABSTRACT Depression is a frequently-seen postpartum complication, with 10-20% prevalence worldwide. Oxytocin has been recognized as a powerful neuromodulator and is present in the mothers' response and bonding with their newborn. Use of intrapartum synthetic oxytocin is a common practice. Objective. To study potential connections between administration of intrapartum synthetic oxytocin and risk of postpartum depression in women from a public hospital in southern Chile, from 2014 to 2015. Material and method. Analytical, prospective cohort study with a consecutive sampling of 58 women, since their third trimester of pregnancy to twelve weeks after birth, using the Edinburgh Postnatal Depression Scale (EPDS). Biopsychosocial and perinatal variables were analyzed (significance level < 0.05). This study was approved by the hospital ethics committee. Results. Average age was 26.07 years. Most of them had attended high school and were homemakers, had free health care and reported a good social support network. 63.7% received synthetic oxytocin. Risk of postpartum depression was 12.07%. Protective factors, and psychosocial and perinatal risk factors, as well as dosage and exposure time, were not statistically significant. Conclusion. According to EPDS, this group showed no statistical relationship between administration of intrapartum oxytocin and postpartum depression symptoms.


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Adolescent , Adult , Oxytocin/adverse effects , Depression, Postpartum , Oxytocin/therapeutic use , Chile , Depression, Postpartum/complications , Parturition
12.
Rev. bras. ginecol. obstet ; 41(3): 147-154, Mar. 2019. tab, graf
Article in English | LILACS | ID: biblio-1003541

ABSTRACT

Abstract Objective The objective of the present study was to explore obstetric management in relation to clinical, maternal and child health outcomes by using the Robson classification system. Methods Data was collected from obstetrics registries in tertiary care hospitals in Dubai, United Arab Emirates (UAE). Results The analysis of > 5,400 deliveries (60% of all the deliveries in 2016) in major maternity hospitals in Dubai showed that groups 5, 8 and 9 of Robson's classification were the largest contributors to the overall cesarean section (CS) rate and accounted for 30% of the total CS rate. The results indicate that labor was spontaneous in 2,221 (45%) of the women and was augmented or induced in almost 1,634 cases (33%). The birth indication rate was of 64% for normal vaginal delivery, of 24% for emergency CS, and of 9% for elective CS.The rate of vaginal birth after cesarean was 261(6%), the rate of external cephalic version was 28 (0.7%), and the rate of induction was 1,168 (21.4%). The prevalence of the overall Cesarean section was 33%; with majority (53.5%) of it being repeated Cesarean section. Conclusion The CS rate in the United Arab Emirates (UAE) is higher than the global average rate and than the average rate in Asia, which highlights the need for more education of pregnant women and of their physicians in order to promote vaginal birth. A proper planning is needed to reduce the number of CSs in nulliparous women in order to prevent repeated CSs in the future. Monitoring both CS rates and outcomes is essential to ensure that policies, practices, and actions for the optimization of the utilization of CS lead to improved maternal and infant outcomes.


Subject(s)
Humans , Female , Pregnancy , Adult , Young Adult , Prenatal Care/statistics & numerical data , Delivery, Obstetric/statistics & numerical data , Tertiary Care Centers/statistics & numerical data , Oxytocics , Pregnancy, Multiple/statistics & numerical data , United Arab Emirates , Oxytocin , Pregnancy Outcome , Cesarean Section/statistics & numerical data , Child Health/statistics & numerical data , Prospective Studies , Analgesia, Obstetrical/statistics & numerical data , Unnecessary Procedures/statistics & numerical data , Term Birth , Anesthesia, Epidural/statistics & numerical data , Labor, Induced/statistics & numerical data , Obstetrical Forceps/statistics & numerical data
13.
Clin. biomed. res ; 39(4): 333-340, 2019.
Article in Portuguese | LILACS | ID: biblio-1087419

ABSTRACT

O cuidado materno negligente, a falta de afeto e a dificuldade de interagir socialmente estão relacionadas com o desequilíbrio neurofisiológico da ocitocina, neurormônio com papel importante de modulação dos comportamentos sociais. Em seres humanos existem ligações conhecidas entre o estresse pré-natal e perinatal e transtornos psiquiátricos e de desenvolvimento. O objetivo deste estudo foi revisar o conceito de epigenética com foco no efeito a longo prazo do cuidado materno negligente e sua relação com alterações do sistema ocitocinérgico baseado em estudos com animais e humanos. Uma revisão narrativa da literatura foi realizada entre junho de 2017 e janeiro de 2019 através da busca de estudos na base PUBMED, com foco nos resultados qualitativos das relações epigenéticas com a negligência infantil, doenças psiquiátricas e sistema ocitocinérgico. Os estudos referidos demonstram que o cuidado materno negligente é um fator de risco para o desenvolvimento de transtornos mentais, principalmente os que incluem sintomas de desordem social. A ocitocina, por agir como uma potente mediadora das interações sociais, confiança e controle da ansiedade, parece ter papel fundamental neste contexto. A notória transgeracionalidade dos transtornos encontrados em proles de mães negligentes parece estar envolvida com mecanismos epigenéticos que inativam genes específicos do sistema ocitocinérgico no sistema nervoso central. (AU)


Negligent maternal care, lack of affection and difficulty in social interaction are related to a neurophysiological imbalance in oxytocin levels, an important modulator of social behaviors. In humans there are known links between prenatal and perinatal stress and psychiatric and developmental disorders. This study aimed to review the concept of epigenetics with a focus on the long-term effect of negligent maternal care and its relationship to changes in the oxytocinergic system, based on animal and human studies. A narrative review of the literature was conducted using studies from June 2017 to January 2019 available in the PUBMED database, focusing on qualitative results of epigenetic relationships with child neglect, psychiatric diseases and oxytocinergic system. These studies demonstrate that negligent maternal care is a risk factor for the development of mental disorders, especially those that include symptoms of social disorder. Oxytocin, as a neurohormone that acts as a potent mediator of social interactions, confidence and anxiety control, seems to play a fundamental role in this context. The notorious transgenerationality of the disorders found in the offspring of negligent mothers seems to be due to epigenetic mechanisms that inactivate specific genes of the oxytocinergic system in the central nervous system.


Subject(s)
Social Behavior Disorders/genetics , Child Care , DNA Methylation/genetics , Maternal Behavior/psychology , Mental Disorders/genetics , Oxytocin/deficiency , Oxytocin/genetics , Child Abuse/psychology , Mental Disorders/psychology
14.
Esc. Anna Nery Rev. Enferm ; 23(4): e20190112, 2019. tab
Article in English | LILACS, BDENF | ID: biblio-1012108

ABSTRACT

Abstract Objectives: To characterize the practices used by nurse-midwives in a Natural Birth Center (NBC) and to verify the maternal and neonatal outcomes. Method: This was a cross-sectional, documentary, retrospective study with a quantitative approach in which the medical records of 300 parturients who gave birth in a state hospital in the city of São Paulo were analyzed. The categories of the World Health Organization (WHO) composed the criteria adopted for the analysis of the obstetric practices. Fisher's exact test or the likelihood ratio and Student t-test were used. Results: The nurse-midwives mostly used category A practices of the WHO. There were no statistically significant associations between practices and perineal outcomes. There was a statistically significant association between the weight of the newborn and the number of neonatal complications, as well as between the delivery position of the primiparous women and clavicle fractures of the newborns. Conclusion and Implications for the practice: Evidence-based practices were followed by the nurse-midwives in the NBC analyzed. The maternal and neonatal outcomes were adequate. There is a need to improve care in the second stage of the delivery in order to avoid behaviors that reflect in neonatal complications. The study makes it possible to reflect on the importance of the continuous evaluation of the care provided.


Resumen Objetivos: Caracterizar las prácticas utilizadas por las enfermeras obstetras en un Centro de Parto Normal (CPN) y verificar los resultados maternos y neonatales. Método: Estudio transversal, documental, retrospectivo, con abordaje cuantitativo, en el cual fueron analizados prontuarios de 300 parturientas que dieron a luz en hospital público de la ciudad de São Paulo. Los criterios adoptados para el análisis de las prácticas obstétricas fueron las categorías de la Organización Mundial de la Salud (OMS). Fueron utilizadas las pruebas, exacto de Fisher o razón de verosimilitud (Likelihood Ratio) y t-Student. Resultados: Las enfermeras obstetras utilizaron mayoritariamente las prácticas de la categoría A de la OMS. No hubo diferencia estadísticamente significativa en las asociaciones entre las prácticas y los resultados perineales. Se observó una diferencia estadísticamente significativa entre el peso del recién nacido y el número de intercurrencias neonatales, así como entre las posiciones de parto de las primíparas con la fractura de clavícula de los recién nacidos. Conclusión e Implicaciones para la práctica: Las prácticas basadas en evidencias son seguidas por las enfermeras obstetras en el CPN analizado. Los resultados maternos y neonatales se mostraron adecuados. Es necesario mejorar la asistencia en el segundo período del parto para evitar conductas que reflejen en las interacciones neonatales. El estudio posibilita la reflexión sobre la importancia de la evaluación continuada de la asistencia prestada.


Resumo Objetivos: Caracterizar as práticas utilizadas pelas enfermeiras obstetras em um Centro de Parto Normal (CPN) e verificar os desfechos maternos e neonatais. Método: Estudo transversal, documental, retrospectivo, com abordagem quantitativa. Analisaram-se prontuários de 300 parturientes que deram à luz em hospital estadual da cidade de São Paulo. Os critérios adotados para a análise das práticas obstétricas foram as categorias da Organização Mundial da Saúde (OMS). Utilizaram-se os testes exatos de Fisher ou razão de verossimilhança (Likelihood Ratio) e t-Student. Resultados: As enfermeiras obstetras utilizaram majoritariamente as práticas da categoria A da OMS. Não houve diferença estatisticamente significativa nas associações entre as práticas e os desfechos perineais. Houve diferença estatisticamente significativa entre o peso do recém-nascido e o número de intercorrências neonatais e entre as posições de parto das primíparas com a fratura de clavícula dos recém-nascidos. Conclusão e Implicações para a prática: As práticas baseadas em evidências são seguidas pelas enfermeiras obstetras no CPN analisado. Os desfechos maternos e neonatais mostraram-se adequados. Há necessidade de melhorar a assistência no segundo período do parto, evitando condutas que reflitam em intercorrências neonatais. O estudo possibilita a reflexão sobre a importância da avaliação continuada da assistência prestada.


Subject(s)
Humans , Female , Pregnancy , Adolescent , Adult , Midwifery/statistics & numerical data , Natural Childbirth/nursing , Nurse Midwives , Obstetric Nursing/statistics & numerical data , Perineum/injuries , Breast Feeding , Oxytocin/therapeutic use , Cardiotocography , Medical Records , Cross-Sectional Studies , Retrospective Studies , Walking , Clavicle/injuries , Episiotomy , Evidence-Based Nursing/statistics & numerical data , Amniotomy , Natural Childbirth/statistics & numerical data
15.
Acta Physiologica Sinica ; (6): 905-916, 2019.
Article in Chinese | WPRIM | ID: wpr-781384

ABSTRACT

One of the core symptoms in anxiety disorders is dysregulated fear response. It is crucial for psychologists and neuroscientists to understand how fear responses are enhanced and inhibited. Although oxytocin (OXT) was initially conceived as a prosocial molecule and mammalian neuropeptide that enhances cooperation and trust, later studies showed that it produces modulatory influence on fear responses. Therefore, OXT is now regarded as a promising pharmacological agent to boost treatment response in anxiety disorders. However, the effect of OXT on fear responses have been somewhat complex, and there are some contradictions among animal experiments and human studies. In this article, we summarize recent studies that employed animal models, brain region-specific manipulations and preclinical studies to explore the role of OXT in the acquisition and processing of fear response. We also discuss the methodological differences among these studies and review the potential factors that may contribute to the complicated effect of OXT on fear response. This review will help to promote the potential clinical application of OXT.


Subject(s)
Animals , Brain , Fear , Humans , Oxytocics , Pharmacology , Oxytocin , Pharmacology
16.
Article in English | WPRIM | ID: wpr-785365

ABSTRACT

BACKGROUND: Nicardipine, a calcium channel blocker, is used to treat hypertension in pregnancy or preterm labor. The current study was conducted to investigate the relaxant effects of nicardipine on the isolated uterine smooth muscle of the pregnant rat.METHODS: We obtained uterine smooth muscle strips from pregnant female SD rats. After uterine contraction with oxytocin 10 mU/ml, we added nicardipine (10⁻¹² to 10⁻⁸ M) accumulatively every 20 min. We recorded active tension and frequency of contraction, and calculated EC₅ (effective concentration of 5% reduction), EC₂₅, EC₅₀, EC₇₅, and EC₉₅ of active tension and frequency of contraction using a probit model.RESULTS: Nicardipine (10⁻¹² to 10⁻⁸ M) decreased active tension and frequency of contraction in a concentration-dependent manner. The EC₅₀ and EC₉₅ of nicardipine in the inhibition of active tension of the uterine smooth muscle were 2.41 × 10⁻¹⁰ M and 3.06 × 10⁻⁷ M, respectively. The EC₅₀ and EC₉₅ of nicardipine in the inhibition of frequency of contraction of the uterine smooth muscle were 9.04 × 10⁻¹¹ and 4.18 × 10⁻⁷ M, respectively.CONCLUSIONS: Nicardipine relaxed and decreased the frequency of contraction of the uterine smooth muscle in a concentration-dependent pattern. It might be possible to adjust the clinical dosage of nicardipine in the obstetric field based on our results, but further clinical studies are needed to confirm them.


Subject(s)
Animals , Calcium Channels , Female , Humans , Hypertension , Muscle, Smooth , Nicardipine , Obstetric Labor, Premature , Oxytocin , Pregnancy , Rats , Relaxation , Uterine Contraction , Uterus
17.
Article in Korean | WPRIM | ID: wpr-787417

ABSTRACT

Neuropeptide oxytocin serves as a neuromodulator in the brain and as a hormone in the body. Oxytocin as a hypothalamic hormone causes contractions during the second and third stages of labor and lets milk come out during breast feeding. As a neuromodulator, oxytocin that influences social affiliative behavior plays an important role in social cognition and emotional learning. Recent studies showed that oxytocin affects basic fear learning and fear extinction precess in a social context. Furthermore, oxytocin has anxiolytic and stress-dampening effects when combined with social support, i.e. a safety stimuli. Also, oxytocin enhances basic emotional learning precesses of both acquisition and extinction of an emotional content while simultaneously decreasing pain experiences. Oxytocin has involvement in attachment, and is shown to improve positive affective behavior in romantic relations. Social buffering effects that social touch and emotional and physical intimacy play crucial roles in coping with negative effects are assumed to be mediated through brain oxytocin mechanisms. Researches indicate that oxytocin significantly inhibits hypothalamic-pituitary-adrenal axis activity in response to stress, and consequently reduces cortisol levels. Conversely, exposure to stress triggers the release of intrahypothalamic and plasma oxytocin. These results suggest that oxytocin may be a new pavement in treating post-traumatic stress disorder and depression.


Subject(s)
Brain , Breast Feeding , Cognition , Depression , Hydrocortisone , Learning , Linear Energy Transfer , Milk , Neuropeptides , Neurotransmitter Agents , Oxytocin , Plasma , Stress Disorders, Post-Traumatic
18.
Article in English | WPRIM | ID: wpr-763710

ABSTRACT

BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell proliferation of corticotroph adenomas. This study aimed to examine whether OXT affects cell growth in pituitary tumor cell lines (AtT20 and GH3 cells) with a focus on corticotroph adenoma cells. METHODS: Reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay were conducted with AtT20 cells to confirm the effects of OXT on hormonal activity; flow cytometry was used to assess changes in the cell cycle after OXT treatment. Moreover, the impact of OXT on proliferating cell nuclear antigen (PCNA), nuclear factor κB, and mitogen-activated protein kinase signaling pathway was analyzed by Western blot. RESULTS: OXT treatment of 50 nM changed the gene expression of OXT receptor and pro-opiomelanocortin within a short time. In addition, OXT significantly reduced adrenocorticotropic hormone secretion within 1 hour. S and G2/M populations of AtT20 cells treated with OXT for 24 hours were significantly decreased compared to the control. Furthermore, OXT treatment decreased the protein levels of PCNA and phosphorylated extracellular-signal-regulated kinase (P-ERK) in AtT20 cells. CONCLUSION: Although the cytotoxic effect of OXT in AtT20 cells was not definite, OXT may blunt cell proliferation of corticotroph adenomas by altering the cell cycle or reducing PCNA and P-ERK levels. Further research is required to investigate the role of OXT as a potential therapeutic target in corticotroph adenomas.


Subject(s)
ACTH-Secreting Pituitary Adenoma , Adrenocorticotropic Hormone , Blotting, Western , Cell Cycle , Cell Line , Cell Proliferation , Corticotrophs , Enzyme-Linked Immunosorbent Assay , Flow Cytometry , Gene Expression , Oxytocin , Phosphotransferases , Pituitary Neoplasms , Polymerase Chain Reaction , Pro-Opiomelanocortin , Proliferating Cell Nuclear Antigen , Protein Kinases , Reverse Transcription
19.
Article in English | WPRIM | ID: wpr-763574

ABSTRACT

OBJECTIVE: Loneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness and hypothalamic-pituitary-adrenal (HPA)-axis activity in drug-naïve patients with major depressive disorder (MDD). METHODS: Twenty-six patients with MDD (male:female = 3:23; mean age, 45.54 ± 12.97 years) were recruited. The 17-item Hamilton Depression Rating Scale, UCLA Loneliness Scale and self-reported Measurement of Support Function Questionnaire were administered. Serum oxytocin and cortisol levels were assessed using a commercial immunoassay kits. RESULTS: In MDD patients, a negative association was found between degrees of social support and loneliness (β = −0.39, p = 0.04). The interaction between social support and serum oxytocin level was negatively associated with loneliness (β = −0.50, p = 0.017) and serum cortisol level (β = −0.55, p = 0.020) after adjusting for age. Follow-up analyses showed that the association between higher social support and lower loneliness was observed only in the higher-oxytocin group (r = −0.75, p = 0.003) but not in the lower group (r = −0.19, p = 0.53). The significance remained after further adjusting for sex and depression severity. CONCLUSION: Low oxytocin level is a vulnerability factor for the buffering effect of social support for loneliness and aberrant HPA-axis activity in MDD patients.


Subject(s)
Buffers , Depression , Depressive Disorder, Major , Follow-Up Studies , Humans , Hydrocortisone , Immunoassay , Loneliness , Oxytocin , Risk Factors
20.
Article in English | WPRIM | ID: wpr-765963

ABSTRACT

BACKGROUND/AIMS: Gastrointestinal (GI) symptoms may develop when we fail to adapt to various stressors of our daily life. Central oxytocin (OXT) can counteract the biological actions of corticotropin-releasing factor (CRF), and in turn attenuates stress responses. Administration (intracerebroventricular) of OXT significantly antagonized the inhibitory effects of chronic complicated stress (CCS) on GI dysmotility in rats. However, intracerebroventricular administration is an invasive pathway. Intranasal administration can rapidly deliver peptides to the brain avoiding stress response. The effects of intranasal OXT on hypothalamus-pituitary-adrenal axis and GI motility in CCS conditions have not been investigated. METHODS: A CCS rat model was set up, OXT 5, 10, or 20 μg were intranasal administered, 30 minutes prior to stress loading. Central CRF and OXT expression levels were analyzed, serum corticosterone and OXT concentrations were measured, and gastric and colonic motor functions were evaluated by gastric emptying, fecal pellet output, and motility recording system. RESULTS: Rats in CCS condition showed significantly increased CRF expression and corticosterone concentration, which resulted in delayed gastric emptying and increased fecal pellet output, attenuated gastric motility and enhanced colonic motility were also recorded. OXT 10 μg or 20 μg significantly reduced CRF mRNA expression and the corticosterone concentration, OXT 20 μg also helped to restore GI motor dysfunction induced by CCS. CONCLUSION: Intranasal administration of OXT has an anxiolytic effect and attenuates the hypothalamus-pituitary-adrenal axis in response to CCS, and gave effects which helped to restore GI dysmotility, and might be a new approach for the treatment of stress-induced GI motility disorders.


Subject(s)
Administration, Intranasal , Animals , Anti-Anxiety Agents , Brain , Colon , Corticosterone , Corticotropin-Releasing Hormone , Gastric Emptying , Gastrointestinal Motility , Models, Animal , Oxytocin , Peptides , Rats , RNA, Messenger
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