Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 3.324
Braz. j. oral sci ; 22: e238329, Jan.-Dec. 2023. il
Article in English | LILACS, BBO | ID: biblio-1434001


Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized". Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen "as needed," at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery

Humans , Male , Female , Pain, Postoperative , Periodontal Diseases , Acetaminophen/therapeutic use
Rev. bras. ortop ; 57(6): 924-929, Nov.-Dec. 2022. tab, graf
Article in English | LILACS | ID: biblio-1423646


Abstract Objective To evaluate the prevalence of persistent pain in the postoperative period of fractures of the distal extremity of the radius, as well as to detect early signs of neuropathic pain to develop protocols for the prevention of chronic postoperative pain. Methods Prospective study, carried out with 56 patients who underwent open reduction and internal fixation of fractures of the distal extremity of the radius with a volar locking plate from March to September 2020. The patients were submitted to assessment of neuropathic pain and functional capacity through the Douleur Neuropathique 4 questionnaire (DN4) and Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH) questionnaires. Qualitative variables were compared using the Mann-Whitney U test and their correlation was analyzed using the Spearman Correlation and Equality of Two Proportions tests. Results A total of 43 patients aged between 18 and 66 years old were included in the present study; 39.5% of the participants scored ≥ 4 on the DN4 questionnaire. In relation to Quick-DASH, the average was 38.6. There was no statistically significant difference between the gender of the patient and the DN4 value (p= 0.921). There was also no statistical correlation between the quantitative variables DN4 and Quick-DASH (p= 0.061). Conclusions The prevalence of neuropathic pain in analyzed postoperative patients was significant, and the presence of signs and symptoms of neuropathic pain was a positive predictive factor for pain persistence beyond 2 months in 100% of cases. Thus, with early diagnosis of the neuropathic component of pain, associated with the nociceptive component, adequate pain control can be achieved, preventing its chronicity, and ensuring better rehabilitation.

Resumo Objetivo Avaliar a prevalência de dor persistente no pós-operatório de fratura da extremidade distal do rádio, assim como detectar precocemente sinais de dor neuropática com o intuito de desenvolver protocolos de prevenção da dor crônica pós-operatória. Métodos Estudo prospectivo, realizado com 56 pacientes submetidos a redução aberta e fixação interna de fratura da extremidade distal do rádio com placa volar bloqueada no período de março a setembro de 2020. Os pacientes foram submetidos a avaliação de dor neuropática e capacidade funcional através dos questionários Douleur Neuropathique 4 questionnaire (DN4) e Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH, na sigla em inglês). As variáveis qualitativas foram comparadas pelo teste de Mann-Whitney e sua correlação foi analisada pelos testes de correlação de Spearman e de Igualdade de Duas Proporções. Resultados Foram incluídos no presente estudo 43 pacientes, com idades entre 18 e 66 anos; 39,5% dos participantes apresentaram pontuação ≥ 4 no questionário Douleur neuropathique 4 questionnaire (DN4). Em relação ao Quick-DASH, a média foi de 38,6. Não houve diferença estatística significante entre o sexo do paciente e o valor do DN4 (p= 0,921). Também não foi encontrada correlação estatística entre as variáveis quantitativas DN4 e Quick-DASH (p= 0,061). Conclusões A prevalência de dor neuropática nos pacientes pós-operatórios analisados foi significativa e a presença de sinais e sintomas de dor neuropática foi fator preditivo positivo para a persistência da dor além de 2 meses em 100% dos casos. Assim, com diagnóstico precoce do componente neuropático de dor, associado ao componente nociceptivo, é possível obter o controle adequado da dor, impedindo sua cronificação e garantindo uma melhor reabilitação.

Humans , Male , Female , Adult , Middle Aged , Pain, Postoperative/prevention & control , Pain Measurement , Surveys and Questionnaires , Radial Head and Neck Fractures/surgery , Radial Head and Neck Fractures/rehabilitation
Rev. otorrinolaringol. cir. cabeza cuello ; 82(2): 279-286, jun. 2022.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1389853


Resumen La palabra placebo ha sido usada, indistintamente, para referir a una sustancia o procedimiento que es "inerte" ("placebo") y al efecto que ocurre como consecuencia de la administración de un placebo ("efecto placebo"). El efecto placebo es un fenómeno psicobiológico que ha sido explicado desde el conductismo (condicionamiento clásico), desde fenómenos preconscientes (expectativas o "efecto placebo clásico"), desde el cognitivismo (disonancia cognitiva) y también a nivel neurobiológico. No obstante, los ensayos clínicos abiertos que verifican la respuesta a placebo desafían el mecanismo de la expectativa, dando lugar al análisis bayesiano, que integra sensaciones, experiencias, predicciones y claves del contexto; biológicamente, el efecto placebo no es inerte. Por tanto, el placebo ocupa un lugar relevante en la práctica clínica y en la investigación biomédica. Se realizó una búsqueda sistemática sobre placebo y otorrinolaringología en las bases de datos PubMed/Medline, SciELO y Cochrane Library. Se incluyeron estudios primarios y revisiones sistemáticas de la literatura. En cuanto a intervenciones placebo, la literatura publicada indica mejorías significativas en síntomas nasales y calidad de vida en rinitis alérgica (estacional y perenne) y disminución del dolor posoperatorio en amigdalectomía. En la enfermedad de Méniere, las intervenciones placebo son comparables a las de uso habitual, incluyendo las quirúrgicas. No se encontraron ensayos clínicos abiertos en otorrinolaringología ni evidencia sobre otras patologías del área. Las intervenciones y el efecto placebo abren un campo de investigación y desarrollo en otorrinolaringología que desafía la comprensión actual de las patologías, su funcionamiento, su tratamiento y la relación terapéutica.

Abstract The word placebo has been used interchangeably to refer to a substance or procedure that is "inert" ("placebo") and the effect that occurs as a consequence of its administration ("placebo effect"). The placebo effect corresponds to a psychobiological phenomenon that has been explained from behaviorism (classical conditioning), from preconscious phenomena (expectations or "classical placebo effect"), from cognitivism (cognitive dissonance) and at the neurobiological level as well. Nevertheless, some open-label trials that verify the response to placebo challenge the expectation mechanism, giving rise to Bayesian analysis, which integrates sensations, experiences, predictions and context clues; therefore, biologically, the placebo effect is not inert. The placebo has a relevant place both in clinical practice and in biomedical research. We conducted a systematic search on placebo and otolaryngology in PubMed/Medline, SciELO and Cochrane Library databases. We included primary studies and systematic reviews. Regarding placebo interventions, the available literature points out significant improvements in nasal symptoms and quality of life in allergic rhinitis (seasonal and perennial) and a decrease in post-tonsillectomy pain. In Méniére's disease, placebo interventions have demonstrated to be comparable to treatment-as-usual, including surgical interventions. No open-label clinical trials were found in otolaryngology, as well as no evidence on other diseases in the area. Placebo interventions and their effects open a field of research and development in otolaryngology, challenging the current understanding of pathologies, their functioning, their treatment and the therapeutic relationship.

Humans , Otolaryngology , Placebo Effect , Pain, Postoperative , Tonsillectomy , Rhinitis, Allergic , Meniere Disease
J. coloproctol. (Rio J., Impr.) ; 42(2): 167-172, Apr.-June 2022. tab
Article in English | LILACS | ID: biblio-1394410


ABSTRACT Background Anal fissure is a common surgical disease that is usually treated conservatively. The golden surgical treatment for anal fissure is lateral internal sphincterotomy, but it may result in multiple complications. Therefore, other treatment methods have recently been introduced, and one of them is the injection of botulinum toxin A (BTA) and fissurectomy. In the present study, we aim to evaluate the effectiveness of the combination of fissurectomy and BTA injection in the treatment of chronic anal fissure by single surgeon. Materials and Methods The present is a non-randomized prospective cohort study conducted by a single surgeon in Saudi Arabia. Our sample was composed of 116 female patients, with mean age of 36.57 ± 11.52 years, who presented to our Surgical Outpatient Clinic with chronic anal fissure between October 2015 and July 2020, and were treated with BTA injection combined with fissurectomy. They were followed up for 1, 2, 3, 4, and 8 weeks, and after one year to evaluate the efficacy and safety of the treatment. The main outcomes analyzed were symptomatic relief, complications, recurrence, and the need for further surgical intervention. Results The treatment with BTA injection combined with fissurectomy was effective and safe in 115 patients (99.1%) at 1 year of follow-up. A total of 5 patients experienced recurrence at 8 weeks, which resolved completely with pharmacological sphincterotomy, and 12 patients experienced minor incontinence, which disappeared later. Conclusion In total, 70 units of BTA injection combined with fissurectomy is a suitable second-line treatment of choice for chronic anal fissure, with a high degree of success and a low rate of major morbidity. (AU)

Humans , Female , Adult , Middle Aged , Aged , Botulinum Toxins, Type A/therapeutic use , Dose-Response Relationship, Drug , Pain, Postoperative , Fecal Incontinence , Fissure in Ano/surgery
Prensa méd. argent ; 108(3): 120-125, 20220000. graf, tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1373050


Introducción: El manejo inmediato del dolor postoperatorio es esencial para una comodidad y rehabilitación temprana del paciente Este estudio busca evaluar el efecto analgésico postoperatorio inmediato en cirugías de columna lumbosacra por vía posterior, como los efectos adversos con la administración de analgesia intratecal, usando Clonidina contra Morfina. Material y métodos: Es un estudio analítico de intervención, cuasi experimental, prospectivo, longitudinal, comparativo, doble ciego. Para comparar la eficacia de la analgesia intratecal post operatoria inmediata en cirugías de columna lumbosacra primarias por vía posterior y los efectos adversos. Los pacientes se distribuyeron en dos grupos previamente designados, a un grupo se le administro Clonidina 0.5 microgramos/kg/peso y a otro grupo Morfina 5 microgramos/Kg/Peso. intratecal, intraoperatorio. Resultados: Existió diferencia estadísticamente significativa con mejor manejo del dolor postoperatorio en las primeras horas y menor presencia de vómitos en el grupo de pacientes que se utilizó Clonidina intratecal. No existió diferencia estadísticamente significativa de ambas medicaciones intratecales en la valoración de otros efectos adversos. Discusión: El uso de la analgesia intratecal ha ido ganando relevancia en el tiempo y se fueron sumando estudios para ver la eficacia de diferentes medicamentos, diferentes dosis, menor presencia de efectos adversos. El estudio analiza estas variables buscando una mejor opción terapéutica. Tenemos a favor una muestra representativa a pesar de no ser aleatoria, estricto seguimiento, y análisis estadístico adecuado. Conclusión: La Clonidina intratecal es más efectiva para manejo del dolor post operatorio inmediato de cirugías de columna lumbosacra por vía posterior y con menor presencia de efectos adversos

Introduction: Immediate postoperative pain management is essential for the patient's greater comfort and early rehabilitation. Te goal of this study is to evaluate the immediate analgesic postoperative effect in posterior lumbosacral spine surgery, as well as the adverse effects of the administration of intrathecal analgesia, using Clonidine versus Morphine. Material and methods: An analytical, quasi-experimental, prospective, longitudinal, comparative, double-blinded intervention study was conducted to compare the efficacy of immediate postoperative intrathecal analgesia in primary posterior lumbosacral spine surgery, and the adverse effects. Te patients were divided into two previously designated groups. One group received Clonidine 0.5 microgramos/kg and the other group received Morphine 5 microgramos/kg. Intrathecal, intraoperative. Results: Tere was a statistically significant difference with better postoperative pain management in the first hours and less vomiting in the group of patients who received intrathecal Clonidine. Tere was no statistically significant difference between both intrathecal medications in the evaluation of other adverse effects. Discussion: Te use of intrathecal analgesia, has been on the rise over time and more studies have been conducted to see the efficacy of different drugs, different doses, with fewer adverse effects. Tis study to analyze these variables with a view to finding a better therapeutic option. Te advantage is having a representative if not random sample, strict follow-up, and appropriate statistical analysis Conclusion: Intrathecal Clonidine proved to be more effective in immediate postoperative pain management after posterior lumbosacral spine surgery and with fewer adverse effects

Humans , Adult , Middle Aged , Aged , Pain, Postoperative/therapy , Pain Measurement , Analgesia, Epidural/methods , Double-Blind Method , Prospective Studies , Longitudinal Studies , Clonidine/administration & dosage , Aftercare , Non-Randomized Controlled Trials as Topic , Lumbosacral Region/surgery , Morphine/administration & dosage
Rev. bras. ortop ; 57(2): 257-266, Mar.-Apr. 2022. tab, graf
Article in English | LILACS | ID: biblio-1388000


Abstract Objective To evaluate postoperative pain, using the visual analog scale (VAS), in patients undergoing anterior cruciate ligament reconstruction (ACLR) and receiving intra-articular anesthetic solutions. Methods The present is a randomized clinical trial with a sample of 48 patients divided into 4 groups: Group I (n » 12) - 20 mL of saline solution (control); Group II (n » 12) - 20 mL of 0.5% bupivacaine; Group III (n » 12) - 20 mL of 0.5% bupivacaine þ 0.1 mg of epinephrine; and Group IV (n » 12) - 20 mL of saline solution þ 0.1 mg of epinephrine. These solutions were injected into the knee at the end of the surgery. Pain was assessed using the VAS immediately and 6, 12, 24 and 48 hours after the procedure. Results The VAS scores were highly variable among the groups. A Kruskal-Wallis analysis of variance (ANOVA), considering a level of significance of 5%, revealed that all intra-articular anesthetic solutions influenced the assessment of pain (p » 0.003), and that Group-III subjects presented less postoperative pain. There was no evidence of a higher or lower use of supplemental analgesic agents, or of adverse effects resulting from these anesthetic solutions. Conclusion Bupivacaine combined with epinephrine was the most effective solution for pain control in patients undergoing ACLR, but with no statistically significant differences when compared to Group II (p » 0.547). There was no decrease or increase in the use of supplemental analgesics or in the occurrence of adverse systemic effects (p > 0.05).

Resumo Objetivo Avaliar primariamente a dor pós-operatória, por meio da escala visual analógica (EVA), nos pacientes submetidos a reconstrução do ligamento cruzado anterior (RLCA) que receberam soluções anestésicas intra-articulares (IAs). Métodos Ensaio clínico randomizado com uma amostra de 48 pacientes, divididos em 4 grupos: Grupo I (n » 12) - 20 ml de solução fisiológica (controle); Grupo II (n » 12) - 20 ml de bupivacaína a 0,5%; Grupo III (n » 12) - 20 ml de bupivacaína a 0,5% þ 0,1 mg de epinefrina; e Grupo IV (n » 12) - 20 ml de solução fisiológica þ 0,1 mg de epinefrina, injetados no joelho ao término da cirurgia. A dor foi avaliada pela EVA imediatamente e 6, 12, 24 e 48 horas após o procedimento. Resultados Observou-se grande variabilidade nos resultados da EVA entre os pacientes avaliados em cada grupo. Verificou-se, pela análise de variância (analysis of variance, ANOVA) de Kruskal-Wallis, considerando um nível de 5% de significância, que as soluções anestésicas IAs de cada grupo influenciaram na avaliação da dor desses pacientes (p » 0,003), sendo os do Grupo III os que apresentaram menor dor pósoperatória. Não se evidenciou um maior ou menor consumo de drogas analgésicas suplementares, ou efeitos adversos das decorrentes das soluções empregadas. Conclusão A solução combinada de bupivacaína e epinefrina foi a mais eficaz no controle da dor nos pacientes submetidos a RLCA, mas sem diferenças estatisticamente significativas com relação ao grupo II (p » 0,547). Não se observou diminuição ou aumento no consumo de analgésicos suplementares, ou o aparecimento de efeitos sistêmicos adversos (p > 0,05).

Humans , Pain, Postoperative/therapy , Pain Measurement , Bupivacaine/therapeutic use , Epinephrine/therapeutic use , Anterior Cruciate Ligament/surgery
Rev. cuba. enferm ; 38(1)mar. 2022.
Article in Spanish | LILACS-Express | LILACS, BDENF, CUMED | ID: biblio-1408313


ntroducción: El control apropiado del dolor es un desafío crucial y necesario de abordar en el campo quirúrgico, al producir un gran impacto en la recuperación del paciente. Objetivo: Evaluar el efecto de una intervención de enfermería aplicada en el periodo perioperatorio para el control del dolor del paciente adulto en el posoperatorio inmediato. Métodos: Estudio cuantitativo, cuasi experimental, con grupo experimental y control de adultos intervenidos en el quirófano de una institución de salud en Bucaramanga - Colombia en el primer semestre de 2017, con un universo de 3240 pacientes y muestra calculada de 120. La intervención constó de tres fases, enmarcada en la teoría de síntomas desagradables. Para evaluar el dolor se utilizó la Escala Visual Análoga. Se realizó análisis descriptivo, bivariado y múltiple, se calcularon Betas con modelos de regresión lineal con los puntajes de la escala de dolor a los 10-20 y 30 minutos, 1- 1,5 y 2 horas. Resultados: Los grupos presentaron características similares, en el grupo experimental disminuyeron los puntajes en la escala de dolor a los 10 minutos en -0,98 (IC 95 por ciento: -2,0; 0,02), a la hora de -0,77(IC 95 por ciento: -1,60; 0,05), a las 1,5 horas de -0,71(IC 95 por ciento: -1,13; -0,12) y las 2 horas de -0,60(IC 95 por ciento: -1,09; -0,10). Conclusiones: La intervención de enfermería en perioperatorio, más allá de la administración de analgésicos, es fundamental para modificar las respuestas, como lo refiere la teoría de Swanson, se mejora o controlan los síntomas desagradables y sus efectos negativos, en este caso el dolor posoperatorio(AU)

Introduction: Appropriate pain control is a crucial and necessary challenge to address in the surgical field, since it would produce a great impact patient recovery. Objective: To assess the effect of a nursing intervention applied during the perioperative period for pain control in the adult patient in the immediate postoperative period. Methods: Quantitative and quasiexperimental study carried out with two groups, an experimental and a control group, of adults operated on in the surgical room of a health institution in Bucaramanga, Colombia, in the first semester of 2017. The universe consisted of 3240 patients, while the calculated sample was 120. The intervention consisted in three phases, framed within the theory of unpleasant symptoms. The visual analog scale was used to assess pain. Descriptive, bivariate and multiple analyses were performed. Betas were calculated with linear regression models and using the scores of the pain scale at ten to twenty and thirty minutes; as well as at one to one and half hours, and two hours. Results: The groups presented similar characteristics: in the experimental group, the scores of the pain scale decreased at ten minutes by 0.98 (95 percent CI: -2.0; 0.02); at one hour, by 0.77 (95 percent CI: -1.60; 0.05; at one and a half hours, by 0.71 (95 percent CI: -1.13; -0.12); and at two hours, by 0.60 (95 percent CI: -1.09; -0.10). Conclusions: The nursing intervention in the perioperative period, beyond the administration of analgesics, is fundamental to modify responses, as referred by Swanson's theory, unpleasant symptoms and their negative effects are improved or controlled; in this case, postoperative pain(AU)

Humans , Adult , Pain, Postoperative , Perioperative Nursing/methods , Standardized Nursing Terminology , Visual Analog Scale , Analgesics/therapeutic use
Rev. cuba. cir ; 61(1)mar. 2022.
Article in Spanish | LILACS-Express | LILACS, CUMED | ID: biblio-1408223


Introducción: La fisura anal crónica es una entidad frecuente que produce molestias durante y después de la defecación, su fisiopatología no es clara y su manejo es variado. La esfinterotomia lateral interna es una de las técnicas más utilizadas, aunque su elevado porcentaje de incontinencia no es aceptado y la inyección de toxina botulínica es una alternativa tentadora. Objetivo: Comparar los resultados de la inyección de toxina botulínica tipo A con la esfinterotomia lateral interna para tratamiento de la fisura anal en cuanto a dolor postoperatorio, recurrencia, curabilidad e incontinencia. Métodos: Se realizó un estudio tipo cohorte. A un grupo de 40 pacientes se trató con inyección de 50 UI de Toxina Botulínica tipo A y el otro grupo de 42 pacientes se le realizó esfinterotomia lateral interna. Los resultados se comparan estadísticamente para CI95 y error de 0,05. Resultados: La esfinterotomia vs toxina botulínica, resultó en cuanto a curabilidad en un 85,4 por ciento de los casos contra un 77,5 por ciento. Las recidivas se presentaron en 4,8 por ciento / 12,5 por ciento, la incontinencia ocurrió en 9,5 por ciento / 2,5 por ciento y el dolor posoperatorio estuvo presente en el 14,8 por ciento / 5,0 por ciento. Conclusiones: La esfinterotomia resultó mejor en cuanto a curabilidad y recidivas, mientras la aplicación de la toxina botulínica presentó mejores resultados en la incontinencia fecal y el dolor posoperatorio(AU)

Introduction: Chronic anal fissure is a frequent entity that produces discomfort during and after defecation. Its pathophysiology is not clear and its management is varied. Lateral internal sphincterotomy is one of the most used techniques, although its high percentage of incontinence is not accepted; botulinum toxin injection is therefore a tempting alternative. Objective: To compare the results of botulinum toxin type A injection or lateral internal sphincterotomy for treatment of anal fissure in terms of postoperative pain, recurrence, healing and incontinence. Methods: A cohort study was carried out. One group of 40 patients were treated with injection of 50 IU of botulinum toxin type A and another group of 42 patients underwent lateral internal sphincterotomy. The results were statistically compared with a confidence interval of 95 percent and error of 0.05. Results: Sphincterotomy and botulinum toxin were effective in terms of healing in 85.4 percent and 77.5 percent of cases, respectively. Recurrences occurred in 4.8 percent and 12.5 percent of cases, respectively. Incontinence occurred in 9.5 percent and 2.5 percent of cases, respectively. Postoperative pain was present in 14.8 percent and 5.0 percent of cases, respectively. Conclusions: Sphincterotomy was better in terms of healing and recurrence, while botulinum toxin application showed better results regarding fecal incontinence and postoperative pain(AU)

Humans , Pain, Postoperative , Botulinum Toxins, Type A/therapeutic use , Fissure in Ano/etiology , Lateral Internal Sphincterotomy/methods , Cohort Studies
Rev. ADM ; 79(1): 38-47, ene.-feb. 2022. tab
Article in Spanish | LILACS | ID: biblio-1361906


Las urgencias odontológicas son, quizá, las razones principales de atención en el consultorio, muchas veces el significado de dolor se encuentra acompañado por inflamación; el uso de antiinflamatorios no esteroideos (AINES) es común en el ejercicio de la odontología por la excelente respuesta analgésica y antiinflamatoria que tiene, por lo que es importante conocer la fisiopatología de la inflamación y el dolor y cómo actúan los AINES, ya que algunos de estos fármacos tienen respuestas adversas y sitios de acción importantes. Los factores de riesgo por inflamación y dolor nos obligan a conocer la variedad de fármacos que no entran en la clasificación de AINES y que tenemos a disposición, hay más opciones para la elección ante la presencia de inflamación por un factor en particular, cada uno de éstos tienen indicaciones y contraindicaciones que conoceremos, lo cual nos ampliará el conocimiento para dar una prescripción ante la presencia de eventos inflamatorios. Se realizó un estudio detallado de artículos bibliográficos de cada tema, los fármacos más usados en odontología son los AINES, hay poco uso y conocimiento de antiinflamatorios que podemos usar en urgencias, el porcentaje de uso de los AINES derivados del ácido propiónico es alto por la excelente respuesta en pacientes y otras veces por el desconocimiento de más opciones (AU)

Dental emergencies are perhaps the main reasons for care in the office, many times the meaning of pain is accompanied by inflammation, the use of non-steroidal anti-inflammatory drugs is common in the practice of dentistry due to the excellent analgesic and anti-inflammatory response it has, important is knowing the pathophysiology of inflammation and pain, how NSAIDs act, some of these drugs have adverse responses and important sites of action, risk factors for inflammation and pain require us to know the variety of drugs that do not enter the classification of NSAIDs and we have at our disposal, there are more options for choosing in the presence of inflammation due to a particular factor, each of these have indications and contraindications that we will know, it expands our knowledge to give a prescription in the presence of inflammatory events. A detailed study of bibliographic articles on each topic was carried out, the drugs most used in dentistry are NSAIDs, there is little use and knowledge of anti-inflammatories that we can use in the emergency room, the percentage of use of NSAIDs derived from propionic acid is high, due to the excellent response in patients and others due to lack of knowledge of more options (AU)

Humans , Male , Female , Toothache , Pharmaceutical Preparations , Anti-Inflammatory Agents, Non-Steroidal , Inflammation , Pain/pathology , Pain, Postoperative , Propionates , Prostaglandins/physiology , Data Interpretation, Statistical , Drug Interactions , Cyclooxygenase 1/pharmacology , Cyclooxygenase 2 , Cyclooxygenase 2 Inhibitors , Narcotics
Säo Paulo med. j ; 140(1): 144-152, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1357465


ABSTRACT BACKGROUND: There is still a debate about what constitutes effective and safe postoperative analgesia in hepatectomy surgery. Erector spinae plane (ESP) block may be an important part of multimodal analgesia application in hepatectomy surgery. OBJECTIVES: To compare the effects of ultrasound-guided bilateral erector spinae plane block combined with intravenous (iv) patient-controlled analgesia (iv PCA), in comparison with iv PCA alone, in hepatectomy surgery. DESIGN AND SETTINGS: Randomized prospective single-blinded study in a tertiary university hospital. METHODS: Fifty patients scheduled for elective hepatectomy surgery were included in the study. Patients were randomized into the ESP group or the control group. In the ESP group, bilateral ESP block was performed preoperatively and iv PCA was used. In the control group, only iv PCA was used. Numerical rating scale (NRS) scores at rest and coughing, analgesic requirements and occurrences of nausea and vomiting were recorded. RESULTS: Intraoperative and postoperative opioid consumption, rescue analgesia requirement and resting and dynamic NRS scores were significantly lower in the ESP group (P < 0.05). There was no significant difference between two groups in terms of the presence of dynamic pain after the first postoperative hour. While all patients in the control group had nausea and vomiting, 24% of the patients in the ESP group did not have nausea and vomiting. CONCLUSION: This study showed that ESP block can be used as a part of multimodal analgesia, with the benefit of reducing opioid consumption and postoperative nausea and vomiting in hepatectomy surgery. CLINICAL TRIAL REGISTRATION: ACTRN12620000466943.

Humans , Analgesics, Opioid , Nerve Block , Pain, Postoperative/prevention & control , Pain, Postoperative/drug therapy , Prospective Studies , Analgesia, Patient-Controlled , Ultrasonography , Hepatectomy/adverse effects
Rev. bras. ginecol. obstet ; 44(1): 55-66, Jan. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365664


Abstract Objective To summarize the available evidence of TAP Block in efficacy in laparoscopic or robotic hysterectomy. Data Sources We searched databases and gray literature for randomized controlled trials in which transversus abdominis plane (TAP) block was compared with placebo or with no treatment in patients who underwent laparoscopic or robot-assisted hysterectomy. Method of Study Selection Two researchers independently evaluated the eligibility of the selected articles. Tabulation, Integration, and Results Seven studies were selected, involving 518 patients. Early postoperative pain showed a difference in the mean mean difference (MD): - 1.17 (95% confidence interval [CI]: - 1.87-0.46) in pain scale scores (I2=68%), which was statistically significant in favor of using TAP block, but without clinical relevance; late postoperative pain: DM 0.001 (95%CI: - 0.43-0.44; I2=69%); opioid requirement: DM 0.36 (95%CI: - 0.94-1.68; I2=80%); and incidence of nausea and vomiting with a difference of 95%CI=- 0.11 (- 0.215-0.006) in favor of TAP. Conclusion With moderate strength of evidence, due to the high heterogeneity and imbalance in baseline characteristics among studies, the results indicate that TAP block should not be considered as a clinically relevant analgesic technique to improve postoperative pain in laparoscopic or robotic hysterectomy, despite statistical significance in early postoperative pain scale scores. Clinical Trial Number and Registry: PROSPERO ID - CRD42018103573.

Resumo Objetivo Resumir as evidências disponíveis sobre a eficácia do bloqueio TAP em histerectomia laparoscópica ou robótica. Fontes de Dados Pesquisamos bancos de dados e literatura cinza por ensaios clínicos randomizados nos quais o bloqueio do plano transverso do abdome (TAP na sigla em inglês) foi comparado com placebo ou com nenhum tratamento em pacientes que foram submetidos a histerectomia laparoscópica ou assistida por robô. Métodos de Seleção de Estudos Dois pesquisadores avaliaram independentemente a elegibilidade dos artigos selecionados. Tabulação, Integração e Resultados Sete estudos foram selecionados envolvendo 518 pacientes. A dor pós-operatória precoce apresentou diferença nasmédias (DM) de: -1 17 (intervalo de confiança [IC] de 95%: - 1 87-0 46) nos escores da escala de dor (I2=68%) o que foi estatisticamente significativo a favor do uso do bloqueio TAP mas sem relevância clínica; dor pós-operatória tardia: DM 0001 (IC95%: - 043-044; I2=69%); necessidade de opioides: DM0 36 (95%CI: - 0 94-168; I2=80%); e incidência de náuseas e vômitos com diferença de 95% CI=- 011 (- 0215-0006) a favor do TAP. Conclusão Com moderada força de evidência devido à alta heterogeneidade e ao desequilíbrio nas características basais entre os estudos os resultados indicam que o bloqueio do TAP não deve ser considerado como uma técnica analgésica clinicamente relevante para melhorar a dor pós-operatória em histerectomia laparoscópica ou robótica apesar da significância estatística nas pontuações da escala de dor pósoperatória inicial. Número e Registro do Ensaio Clínico: PROSPERO ID - CRD42018103573.

Pain, Postoperative/prevention & control , Laparoscopy/methods , Robotic Surgical Procedures/methods , Analgesics, Opioid/therapeutic use , Pain, Postoperative/drug therapy , Robotics , Abdominal Muscles , Hysterectomy/methods
Rev. bras. ortop ; 57(1): 150-158, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365739


Abstract Objective To compare the techniques for the osteosynthesis of intertrochanteric fractures with dynamic hip screws (DHSs) through the Hardinge and minimally-invasive access routes of the hip, evaluating the operative time, the degree of pain in the immediate postoperative period, the hematimetric loss, and the functional aspects of active mobility. Methods A randomized, double-blinded clinical trial in which 66 patients with intertrochanteric fractures were submitted to osteosynthesis by DHS. The patients were divided into a test group, submitted to the minimally-invasive access, and a control group, in whom the surgery was performed through the Hardinge route. Results Patients submitted to the minimally-invasive treatment presented a lower degree of postoperative pain compared to the group treated by the Hardinge lateral route (p< 0.001), as well as lower hematimetric loss (p< 0.001), shorter operative time (p< 0.001), and improvement in immediate postoperative active mobility tests (p <0.05). Conclusion The study demonstrated the clinical superiority of the minimally-invasive access route parameters analyzed in relation to the Hardinge access for the fixation of intertrochanteric fractures when DHS is the choice osteosynthesis method. Level of evidence I.

Resumo Objetivo Comparar as técnicas de osteossíntese de fraturas intertrocantéricas com o parafuso dinâmico de quadril (dynamic hip screw, DHS, em inglês) pelas vias de acesso de Hardinge e minimamente invasiva do quadril, avaliando o tempo cirúrgico, o grau de dor no pós-operatório imediato, a perda hematimétrica, e os aspectos funcionais de mobilidade ativa. Métodos Estudo clínico randomizado e duplo-cego, em que 66 pacientes com fratura intertrocantérica foram submetidos a osteossíntese com DHS. Os pacientes foram divididos em um grupo teste, submetidos ao acesso minimamente invasivo, e um controle, em que a cirurgia foi realizada pela via de Hardinge. Resultados Os pacientes submetidos ao tratamento pela via minimamente invasiva apresentaram um grau de dor pós-operatória inferior em comparação ao grupo tratado pela via lateral de Hardinge (p< 0,001), assim como menor perda hematimétrica (p< 0,001), menor tempo operatório (p< 0,001), e melhora nos testes de mobilidade ativa pós-operatória imediata (p< 0,05). Conclusão O estudo demonstrou a superioridade clínica nos parâmetros analisados da via de acesso minimamente invasiva em relação ao acesso de Hardinge para a fixação de fraturas intertrocantéricas, quando o DHS for a opção de osteossíntese escolhida. Nível de evidência I.

Humans , Male , Female , Aged , Aged, 80 and over , Pain, Postoperative , Postoperative Period , Control Groups , Clinical Trial , Minimally Invasive Surgical Procedures , Fracture Fixation, Internal , Hip Fractures
Braz. dent. sci ; 25(3): 1-9, 2022. tab, ilus
Article in English | LILACS, BBO | ID: biblio-1382182


Objective: To evaluate incidence and intensity of postoperative pain in patients treated in the Residency Program in Endodontics at the State University of Maringá. The influence of factors inherent to the patient and treatment on preoperative pain was also the focus of our study. Material and Methods: 99 patients participated in this study and underwent non-surgical endodontic treatment. Initially, palpation, vertical and horizontal percussion were performed on the tooth to be treated. After the root canals filling, patients received a printed Numerical Rating Scale and were instructed to record the level of pain in the postoperative periods of 24, 48 and 72 hours. For each postoperative period, the patient recorded the values. A descriptive analysis of the data and a model of generalized estimation equations were performed to verify the relationship between the variables and postoperative pain, at a significance level of 5%. Results: During the follow-up period, the pain rates found were low represented by 16%, 11% and 7% in the periods of 24, 48, and 72h, respectively. In addition, the rates significantly decreased after 72h. Only one case of flare-up was recorded. Presence of pain on palpation, use of reciprocating file and use of 2.5% sodium hypochlorite influenced the results (p<0.05), increasing the changes of post-operative pain by 3.36, 0.4 and 0.2 times, respectively. Conclusion: Incidence and intensity of postoperative pain monitored in the residency program reduced significantly after 72 hours. Postoperative pain was associated with pain on palpation, use of reciprocating files and irrigation with 2.5% hypochlorite.(AU)

Objetivo: Avaliar a incidência e intensidade da dor pós-operatória em pacientes atendidos no Programa de Residência em Endodontia da Universidade Estadual de Maringá. A dor do paciente foi monitorada após 24, 48 e 72 horas após a obturação do canal radicular. A influência de fatores inerentes ao paciente e ao tratamento na dor pré-operatória também foi foco de nosso estudo. Material e Métodos: 99 pacientes participaram deste estudo e foram submetidos a tratamento endodôntico não cirúrgico. Inicialmente, foram realizadas palpação, percussão vertical e horizontal no dente a ser tratado. A presença de dor foi classificada em uma Escala Numérica de Avaliação (NRS). Após a obturação dos canais radiculares, os pacientes receberam a NRS impressa e foram orientados a registrar o nível de dor nos pós-operatórios de 24, 48 e 72 horas. A cada pós-operatório, um pesquisador entrava em contato com o paciente e registrava os valores. Foi realizada uma análise descritiva dos dados e um modelo de equações de estimativa generalizada (GEE) para verificar a relação entre as variáveis e a dor pós-operatória, ao nível de significância de 5%. Resultados: Durante o período de acompanhamento, os índices de dor encontrados foram baixos representados por 16%, 11% e 7% nos períodos de 24, 48 e 72h, respectivamente. Além disso, as taxas diminuíram significativamente após 72h. Apenas um caso de reagudecimento foi registrado. Presença de dor à palpação, uso de lima reciprocante e uso de hipoclorito de sódio 2,5% influenciaram os resultados (p<0,05) aumentando as alterações da dor pós-operatória em 3,36, 0,4 e 0,2 vezes, respectivamente. O tempo médio de encaminhamento foi de 6,28 meses, o que não influenciou nos resultados. Conclusão: A incidência e intensidade da dor pós-operatória monitorada no programa de residência reduziram significativamente após 72 horas. A dor pós-operatória foi associada à dor à palpação, uso de limas reciprocantes e irrigação com hipoclorito a 2,5%. (AU)

Humans , Pain, Postoperative , Pain Measurement , Endodontics
Rev. Hosp. Clin. Univ. Chile ; 33(3): 211-225, 2022. ilus.
Article in Spanish | LILACS | ID: biblio-1417200


Osteoarthrosis of the knee is one of the most important causes of disability around the world, being total knee arthroplasty (TKA) a cost-effective surgical procedure for treating its severe stage when all knee compartments are compromised. Despite the good functional results and good survival of the implants and of the patients, still, 15 to 20% of the patients are dissatisfied after surgery. One of the causes of dissatisfaction is persistent pain located in the anterior part of the knee, which leads to controversy over whether to perform the patellar replacement. Advantages and complications are described in both scenarios, and neither is superior to the other in pain and implant survival. In the case of TKA without patellar replacement, the position of the femoral component plays a crucial role in achieving normal patellar tracking. The current challenge is to determine those clinical and radiological variables that allow us to predict the absence of long-term anterior pain in patients who require TKA and who do not undergo patellar replacement. (AU)

Humans , Male , Female , Middle Aged , Aged , Pain, Postoperative/complications , Arthroplasty, Replacement, Knee/adverse effects , Osteoarthritis, Knee/surgery , Postoperative Complications , Arthroplasty, Replacement, Knee/methods
Article in Spanish | LILACS, BINACIS | ID: biblio-1367128


Introducción: Las fracturas diafisarias y distales de tibia son lesiones frecuentes en personas jóvenes que sufren un trauma de alta energía y en ancianos por un trauma de baja energía. El objetivo de este estudio fue comparar el tiempo quirúrgico, el uso de radioscopia, la evaluación funcional y el dolor en el tratamiento de fracturas diafisarias y distales de tibia mediante una técnica suprarrotuliana y una infrarrotuliana. Materiales y métodos: Se realizó un estudio retrospectivo entre marzo de 2018 y octubre de 2019. La información de los pacientes se obtuvo de la historia clínica electrónica. Se incluyó a pacientes con fracturas diafisarias y distales de tibia. Se estudiaron y compararon los tiempos de radioscopia y de cirugía. El dolor posoperatorio se evaluó mediante la escala analógica visual y la función, con el puntaje de Lysholm. Resultados:Ochenta pacientes cumplían con los criterios de inclusión. Sus datos sociodemográficos fueron pareados en dos grupos similares. Treinta y seis pacientes fueron tratados con la técnica infrarrotuliana y 44, con la técnica suprarrotuliana. Se obtuvieron diferencias estadísticamente significativas en el tiempo de cirugía, el tiempo de radioscopia y en el puntaje de la escala analógica visual para dolor al año. Conclusiones: Los resultados mostraron un menor tiempo de cirugía y de radioscopia, y mejores resultados en la escala analógica visual para dolor con la técnica suprarrotuliana para el tratamiento de las fracturas mediodiafisarias y distales de tibia. Nivel de Evidencia: III

Introduction: Fractures of the medial and distal tibial segment often occur in young patients with high-energy trauma and older patients with low-energy trauma. The objective of this study is to compare the time of surgery, time of use of fluoroscopy, functional outcomes, and postoperative pain in patients treated with the suprapatellar vs. infrapatellar technique for tibial nailing. materials and methods: We carried out a retrospective study between March 2018 and October 2019. All the data was collected from the electronic clinical record (ECR). We included patients with diaphyseal and distal tibial fractures. The variables analyzed were: fluoroscopy and surgery time, pain evaluation, and functional outcomes of the patients using the Lysholm score. Results: 80 patients met all the inclusion criteria. Sociodemographic data were divided into 2 similar groups. The suprapatellar approach was used in 44 patients and the infrapatellar in 36 of them. A statistical difference was obtained in the analysis for the time of surgery, use of fluoroscopy, and pain evaluation in favor of the suprapatellar technique. Conclusions: The results of our study showed shorter surgery and fluoroscopy times with the use of the suprapatellar technique compared with the infrapatellar technique. The suprapatellar technique also yielded better pain results in the visual analog scale. Level of Evidence: III

Adult , Middle Aged , Pain, Postoperative , Tibial Fractures/surgery , Pain Measurement , Retrospective Studies , Treatment Outcome , Fracture Fixation, Intramedullary
Journal of Integrative Medicine ; (12): 329-337, 2022.
Article in English | WPRIM | ID: wpr-939891


OBJECTIVE@#This study evaluated the effectiveness of acupuncture treatment on postoperative pain in patients with degenerative lumbar spine disease, and explored the relationship between the postoperative analgesic effect of acupuncture and the sensation of acupuncture experienced by the patients.@*METHODS@#This retrospective study analyzed the medical records of 97 patients who had undergone an operation by the same surgeon due to degenerative lumbar disease. These patients were divided into acupuncture group (n = 32), patient-controlled analgesia (PCA) group (n = 27), and oral analgesia group (n = 38) according to the different postoperative analgesic methods. During their hospitalization, patients completed daily evaluations of their pain using a visual analogue scale (VAS), and injection times of supplemental meperidine were recorded. Also, the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale (C-MASS) was used in the acupuncture group.@*RESULTS@#Each of the three treatment groups showed significant reductions in postoperative pain, as shown by reduced VAS scores. The acupuncture group, however, had less rebound pain (P < 0.05) than the other two groups. Both the acupuncture and PCA groups experienced acute analgesic effects that were superior to those in the oral analgesia group. In addition, the higher the C-MASS index on the second day after surgery, the lower the VAS score on the fourth day after surgery. There was also a significant difference in the "dull pain" in the acupuncture sensation.@*CONCLUSION@#The results demonstrated that acupuncture was beneficial for postoperative pain and discomfort after simple surgery for degenerative spinal disease. It is worth noting that there was a disproportionate relevance between the patient's acupuncture sensation and the improvement of pain VAS score.

Acupuncture Points , Acupuncture Therapy , Analgesia/methods , Analgesics/therapeutic use , Consensus , Humans , Pain, Postoperative/drug therapy , Prospective Studies , Retrospective Studies , Sensation
Journal of Integrative Medicine ; (12): 321-328, 2022.
Article in English | WPRIM | ID: wpr-939890


BACKGROUND@#Patients commonly develop postoperative pain after total knee arthroplasty (TKA). Acupuncture-related techniques and low-level laser therapy could be beneficial for pain management for older individuals.@*OBJECTIVE@#To examine the effect of low-level laser acupuncture (LA) in reducing postoperative pain, pain-related interference in daily life, morphine consumption, and morphine-related side effects in older patients with knee osteoarthritis who underwent TKA.@*DESIGN, SETTING, PARTICIPANTS AND INTERVENTION@#A single-blind randomized placebo-controlled trial was conducted. Patients (N = 82) were recruited and randomly assigned via a computer-generated list to the LA group or a placebo group. The LA group received low-level laser therapy at Sanyinjiao (SP6), Taixi (KI3), Kunlun (BL60), Fengshi (GB31), Futu (ST32) and Neiguan (PC6) after TKA, while the placebo acupuncture group received the same treatment procedure without laser energy output.@*MAIN OUTCOME MEASURES@#The primary outcome was postoperative pain intensity, and it was measured at baseline and hours 2, 6, 10, 24, 48 and 72 after TKA. The secondary outcomes, including relative pain, postoperative pain-related interference in daily life and morphine consumption, were measured at hours 24, 48 and 72 after TKA.@*RESULTS@#Generalized estimating equations revealed significant between-group differences in pain intensity (P = 0.01), and trend differences in pain intensity for the LA group starting at hours 10 to 72 (P < 0.05) and morphine consumption at hours 48 and 72 (P < 0.05). The changes in pain-related interference in daily life were significant (P < 0.05) at 72 h, with the exception of the parameters for worst pain, mood, and sleep. Nausea and vomiting side effects from morphine had significant between-group differences at hours 10 and 24 (P < 0.05).@*CONCLUSION@#Low-level LA gradually reduced older patients' postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis. Low-level LA may have benefits as an adjuvant pain management technique for clinical care.@*TRIAL registration number NCT03995446.

Acupuncture Therapy , Aged , Analgesics, Opioid/therapeutic use , Arthroplasty, Replacement, Knee/adverse effects , Double-Blind Method , Humans , Morphine/therapeutic use , Pain, Postoperative/drug therapy , Single-Blind Method
Article in English | WPRIM | ID: wpr-928244


Background Ultrasound-guided continuous thoracic paravertebral block can provide pain-relieving and opioid-sparing effects in patients receiving open hepatectomy. We hypothesize that these effects may improve the quality of recovery (QoR) after open hepatectomy. Methods Seventy-six patients undergoing open hepatectomy were randomized to receive a continuous thoracic paravertebral block with ropivacaine (CTPVB group) or normal saline (control group). All patients received patient-controlled intravenous analgesia with morphine postoperatively for 48 hours. The primary outcome was the global Chinese 15-item Quality of Recovery score on postoperative day 7, which was statistically analyzed using Student's t-test. Results Thirty-six patients in the CTPVB group and 37 in the control group completed the study. Compared to the control group, the CTPVB group had significantly increased global Chinese 15-item Quality of Recovery scores (133.14 ± 12.97 vs. 122.62 ± 14.89, P = 0.002) on postoperative day 7. Postoperative pain scores and cumulative morphine consumption were significantly lower for up to 8 and 48 hours (P < 0.05; P = 0.002), respectively, in the CTPVB group. Conclusion Perioperative CTPVB markably promotes patient's QoR after open hepatectomy with a profound analgesic effect in the early postoperative period.

Anesthetics, Local/therapeutic use , Double-Blind Method , Hepatectomy/adverse effects , Humans , Morphine/therapeutic use , Pain Measurement , Pain, Postoperative/etiology , Ultrasonography, Interventional
In. Graña, Andrea; Calvelo, Estela; Fagúndez, Yohana. Abordaje integral del paciente con cáncer: atención desde la medicina y especialidades. Montevideo, Cuadrado, 2022. p.428-433, ilus.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1418097
In. Graña, Andrea; Calvelo, Estela; Fagúndez, Yohana. Abordaje integral del paciente con cáncer: atención desde la medicina y especialidades. Montevideo, Cuadrado, 2022. p.467-488, tab.
Monography in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1418101