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1.
Arch. argent. pediatr ; 120(3): e123-e127, junio 2022. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1368455

ABSTRACT

El síndrome de quilomicronemia familiar (SQF) es unaenfermedad autosómica recesiva rara, con una prevalencia1:200 000 - 1:1 000 000, y se caracteriza por quilomicronemiaen ayunas y niveles muy elevados de triglicéridos (> 880 mg/dl). LPL es el gen más frecuentemente afectado, luego APOC2,GPIHBP1, APOA5 y LMF1; todos ellos comprometen la función de la lipoproteinlipasa endotelial. El SQF suele presentarseen la infancia con dolor abdominal recurrente, xantomaseruptivos, retraso del crecimiento, pancreatitis y, en ocasiones,asintomático. El tratamiento convencional es la restriccióndietética de grasas. Se muestra el resultado clínico de 20 pacientes pediátricoscon SQF reclutados de 4 hospitales en Argentina.


Familial chylomicronemia syndrome (FCS) is a rare autosomalrecessive disease, prevalence 1:200,000 - 1:1,000,000, andis characterized by fasting chylomicrons and very hightriglycerides > 880 mg/dl. LPL is the most frequentlyaffected gene, then APOC2, GPIHBP1, APOA5, LMF1, all ofthem compromising the function of lipoproteinlipase. FCScommonly presents in childhood with recurrent abdominalpain, eruptive xanthomas, failure to thrive, pancreatitis, andsometimes asymptomatic. The conventional treatment isdietetic fat restriction. The clinical outcome of 20 pediatric patients with FCS recruited from 4 hospitals in Argentina is reported.


Subject(s)
Humans , Infant , Child, Preschool , Child , Pancreatitis/diagnosis , Pancreatitis/etiology , Pancreatitis/therapy , Hypertriglyceridemia/genetics , Hyperlipoproteinemia Type I/diagnosis , Hyperlipoproteinemia Type I/genetics , Hyperlipoproteinemia Type I/therapy
2.
Einstein (Säo Paulo) ; 20: eRW6667, 2022. tab, graf
Article in English | LILACS | ID: biblio-1360402

ABSTRACT

ABSTRACT This review aimed to investigate whether SARS-CoV-2 is capable of infecting the gland and causing acute pancreatitis, and the peculiarities in the management of these cases. The research was conducted through PubMed® database, and 62 articles were systematically selected for analysis. Differences were found in the literature; however, there are important warnings, such as the presence of hyperlipasemia, clinical and imaging findings suggestive of acute pancreatitis in the presence and even in the absence of respiratory symptoms. Attention should be paid to clinical and imaging findings during this virus infection, since it is possible to identify these two diseases early. Therefore, it is possible to detect and isolate these patients more quickly, providing the correct care and decreasing the morbidity and mortality of two potentially severe diseases.


Subject(s)
Humans , Pancreatitis/etiology , Pancreatitis/diagnostic imaging , COVID-19 , Acute Disease , SARS-CoV-2
3.
Arq. gastroenterol ; 58(3): 270-275, July-Sept. 2021. tab
Article in English | LILACS | ID: biblio-1345283

ABSTRACT

ABSTRACT BACKGROUND: Endoscopic retrograde cholangiopancreatography is a widely used therapeutic modality for the pancreaticobiliary tree. However, it is responsible for the highest rates of complications among the endoscopic procedures, especially post-endoscopic retrograde cholangiopancreatography pancreatitis. The preventive methods include mechanical and pharmacological approaches, such as the use of non-steroidal anti-inflammatory drugs. OBJECTIVE: To compare the efficacy of two different strategies using non-steroidal anti-inflammatory drugs for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis, and to clarify the uncertainty about the route of administration of non-steroidal anti-inflammatory drugs in the prevention of this complication. METHODS: This was a prospective trial. Two therapeutic groups were compared with a control group that was composed of patients who underwent endoscopic retrograde cholangiopancreatography, performed in the same service and by the same team in the period preceding the study (historical series), without the administration of any type of prophylaxis. The first group received 100 mg rectal diclofenac. The second group received 100 mg intravenous ketoprofen. Both groups were compared, separately and jointly, with the control group. RESULTS: Post-endoscopic retrograde cholangiopancreatography pancreatitis occurred in 4.39% (12/273) of the participants. In the group without prophylaxis, the incidence was 6.89% (10/145). Among those who received intravenous ketoprofen, the incidence was 2.56% (2/78). No cases of acute post-procedural pancreatitis were observed in the group that received rectal diclofenac (0/52). Although there was no statistical difference between the therapeutic groups when they were separately analyzed, a statistical difference in the prevention of post-procedural pancreatitis was observed when they were analyzed together (P=0.037). CONCLUSION: This study provides evidence for the efficacy of non-steroidal anti-inflammatory drugs in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis.


RESUMO CONTEXTO: A colangiopancreatografia retrógrada endoscópica (CPRE) é uma modalidade terapêutica amplamente utilizada para vias biliopancreáticas, responsável pelas taxas mais elevadas de complicações entre os procedimentos endoscópicos, especialmente a pancreatite pós-CPRE (PPC). Os métodos preventivos incluem abordagens mecânicas e farmacológicas, entre elas, a utilização de antinflamatórios não esteroidais (AINEs). OBJETIVO: Comparar a eficácia de duas estratégias diferentes utilizando AINEs para a prevenção de PPC. Elucidar o cenário incerto sobre a via de administração do AINEs na prevenção da PPC. MÉTODOS - Ensaio clínico prospectivo. Duas estratégias terapêuticas foram comparadas a um grupo controle, composto por pacientes submetidos a CPRE no mesmo serviço e com a mesma equipe no período anterior ao estudo (série histórica), que não recebeu qualquer tipo de profilaxia. O primeiro grupo experimental recebeu 100 mg de diclofenaco via retal, o segundo grupo recebeu 100 mg de cetoprofeno endovenoso. Ambos os grupos foram comparados separadamente e em associação com o grupo de controle. RESULTADOS: A PPC ocorreu em 4,39% (12/273) dos participantes. No grupo sem profilaxia, esta incidência foi de 6,89% (10/145); entre os que receberam cetoprofeno endovenoso foi de 2,56% (2/78). Não houve casos de pancreatite aguda após o procedimento no grupo que recebeu diclofenaco via retal (0/52). Apesar de não haver diferença estatística entre estes grupos analisados separadamente, quando os dois grupos terapêuticos são analisados em conjunto estes apresentam diferenças estatísticas na prevenção da PPC (P=0,037). CONCLUSÃO: Este estudo foi capaz de corroborar a eficácia da utilização de AINEs para a profilaxia de pancreatite pós-CPRE.


Subject(s)
Humans , Pancreatitis/etiology , Pancreatitis/prevention & control , Cholangiopancreatography, Endoscopic Retrograde/adverse effects , Anti-Inflammatory Agents, Non-Steroidal , Diclofenac , Prospective Studies
4.
Rev. Soc. Bras. Clín. Méd ; 18(4): 227-230, DEZ 2020.
Article in Portuguese | LILACS | ID: biblio-1361636

ABSTRACT

A ansa pancreática é uma variação anatômica rara dos ductos pancreáticos. Consiste numa comunicação entre o ducto pancreático principal (Wirsung) e o ducto pancreático acessório (Santorini). Recentemente, estudos têm demonstrado estar essa variação anatômica implicada como fator predisponente e significativamente associada a episódios recorrentes de pancreatite aguda. A pancreatite é uma entidade clínica pouco frequente na infância. Diferente dos adultos, as causas mais comuns incluem infecções virais, por ascaris, medicamentosas, traumas e anomalias estruturais. O objetivo deste estudo foi relatar um caso de pancreatite aguda grave não alcoólica e não biliar, em um paciente jovem de 15 anos, em cuja propedêutica imagenológica evidenciou-se alça, comunicando com os ductos pancreáticos ventral e dorsal, compatível com ansa pancreática.


Ansa pancreatica is a rare anatomical variation of the pancreatic ducts. It consists of communication between the main pancreatic duct (Wirsung) and the accessory pancreatic duct (Santorini). Recently, studies have shown that this anatomical variation is implicated as a predisposing factor and significantly associated with recurrent episodes of acute pancreatitis. Pancreatitis is a rare clinical entity in childhood. Different from that in the adults, the most common causes include viral and ascaris infections, drugs, traumas, and structural abnormalities. The objective of this study was to report a case of a severe non-alcoholic and non-biliary acute pancreatitis in a 15-year-old patient, whose propedeutic imaging showed a loop communicating with the ventral and dorsal pancreatic ducts, consistent with ansa pancreatica.


Subject(s)
Humans , Male , Adolescent , Pancreatic Ducts/abnormalities , Pancreatic Ducts/diagnostic imaging , Pancreatitis/etiology , Pancreatitis/diagnostic imaging , Pancreatic Pseudocyst/diagnostic imaging , Pancreatitis/complications , Pancreatitis/blood , C-Reactive Protein/analysis , Magnetic Resonance Spectroscopy , Tomography, X-Ray Computed , Ichthyosis Vulgaris/diagnosis , Ultrasonography , Bile Ducts, Extrahepatic/pathology , Pancreatitis, Acute Necrotizing/etiology , Pancreatitis, Acute Necrotizing/diagnostic imaging , Amylases/blood , Lipase/blood
5.
Revista Digital de Postgrado ; 9(2): 207, ago. 2020. graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1102940

ABSTRACT

La pancreatitis es una de las consecuencias principales del envenenamiento escorpiónico producido por el género Tityus. El manejo farmacológico mediante el uso de agonistas y antagonistas α adrenérgicos en modelos experimentales in vivo e in vitro, permiten establecer una aproximación del papel del Sistema Nervioso Simpático (SNS) en el desarrollo de la pancreatitis. Objetivo: determinar el papel del SNS en el desarrollo de la pancreatitis aguda inducida por el veneno de escorpión Tityus zulianus (TzV), por medio del uso de simpaticolíticos como la clonidina y el prazosin. Métodos: La Extravasación de Proteínas Plasmáticas (EPP) en el páncreas se evaluó mediante el método de Azul de Evans (AE), modificado de Saria y Lundberg (1983) a 620 nm; n=3 ratones NIH en cada grupo experimental. Las comparaciones se hicieron por ANOVA de una vía y las pruebas post HOC por Tukey-Kramer. Resultados: Ambos fármacos (1mg/Kg), disminuyeron significativamente p< 0,01 (**) la EPP en el páncreas inducida por el TzV, en comparación con los animales inoculados solo con TzV. No hubo diferencias significativas entre los animales del grupo control y los grupos tratados con los fármacos más el TzV. Conclusiones: El efecto pancreatotóxico del TzV en ratones podría tener un componente autonómico dado que drogas simpaticolíticas al disminuir la actividad noradrenérgica reducen la magnitud del edema. Esto sugiere que ambos fármacos pueden usarse como estrategia terapéutica en estos casos(AU)


Pancreatitis is one of the main consequences of scorpionic poisoning produced by the genus Tityus. The pharmacological management through the use of agonists and α adrenergic antagonists in experimental models in vivo and in vitro, allow us to establish an approximation of the role of the Sympathetic Nervous System (SNS) in the development of pancreatitis. Objective: to determine the role of SNS in the development of acute pancreatitis induced by the scorpion venom Tityus zulianus (TzV), through the use of sympatholytics such as clonidine and prazosin. Methods: Plasma Protein Extravasation (PPE) in the pancreas was evaluated by the method of Evans Blue (EA), modified by Saria and Lundberg (1983) at 620 nm; n = 3 NIH mice in each experimental group. Comparisons were made by one-way ANOVA and post-HOC tests by Tukey-Kramer. Results: Both drugs (1mg / Kg) significantly decreased p <0.01 (**) the EPP in the pancreas induced by TzV, compared to animals inoculated only with TzV. There were no significant differences between the animals in the control group and the groups treated with drugs plus TzV. Conclusions: The pancreatotoxic effect of TzV in mice could have an autonomic component since sympatholytic drugs by decreasing noradrenergic activity reduce the magnitude of edema. This suggests that both drugs can be used as a therapeutic strategy in these cases(AU)


Subject(s)
Animals , Mice , Pancreatitis/etiology , Scorpion Venoms , Sympathetic Nervous System/drug effects , Pharmacology, Clinical , Prazosin/therapeutic use , Clonidine/therapeutic use
6.
Rev. colomb. cancerol ; 24(2): 88-91, abr.-jun. 2020. graf
Article in Spanish | LILACS | ID: biblio-1144325

ABSTRACT

Resumen El carcinoma de célula pequeña (CPCP) o microcítico de pulmón es un subtipo de cáncer de pulmón que típicamente se ha asociado al tabaquismo y que se caracteriza por su agresividad y mal pronóstico a corto plazo. Como entidad, puede metastatizar en cualquier órgano, siendo las metástasis pancreáticas raras y la mayoría de las veces asintomáticas. Por ello, la presencia de una pancreatitis neoplásica, como en el caso presentado, es excepcional, y aún más cuando presenta refractariedad al tratamiento médico convencional y responde al tratamiento citotóxico sistémico. Por todo ello, se expone esta experiencia clínica y se debate la presencia de esta rara entidad y su manejo.


Abstract Small-cell lung carcinoma is a subtype of neoplasm that has been typically associated with smoking; it is characterized by its aggressiveness and poor prognosis in the short term. As an entity, it can metastasize in any organ, but pancreatic metastases are rare and most of the time asymptomatic. Therefore, the presence of neoplastic pancreatitis as in our case is exceptional; even more when it presents refractoriness to conventional medical treatment, responding instead to systemic cytotoxic treatment. Therefore, we expose our clinical experience and discuss the presence of this rare entity and its management.


Subject(s)
Humans , Male , Middle Aged , Pancreatic Neoplasms/secondary , Pancreatitis/etiology , Small Cell Lung Carcinoma/pathology , Lung Neoplasms/pathology , Pancreatic Neoplasms/drug therapy , Pancreatic Neoplasms/diagnostic imaging , Tobacco Use Disorder/complications , Acute Disease , Cisplatin/therapeutic use , Etoposide/therapeutic use , Small Cell Lung Carcinoma/drug therapy , Small Cell Lung Carcinoma/diagnostic imaging , Lung Neoplasms/drug therapy , Lung Neoplasms/diagnostic imaging , Antineoplastic Agents/therapeutic use
7.
J. pediatr. (Rio J.) ; 95(6): 713-719, Nov.-Dec. 2019. tab
Article in English | LILACS | ID: biblio-1056665

ABSTRACT

ABSTRACT Objective: To describe the epidemiology and clinical features of acute pancreatitis and recurrent acute pancreatitis in children. Methods: Observational and retrospective study with an analytical component. Patients were classified into two groups: Acute pancreatitis and recurrent pancreatitis. The relationship with each parameter obtained was analyzed using the chi-squared test, Student's t-test, or the Mann-Whitney U test. Results: There were 130 patients with acute pancreatitis; recurrent pancreatitis was diagnosed in 23.8% of the cases. The most frequent causes were anatomical (29.6%), pharmacological (19.2%), and biliary (14.6%), although in 29.2% etiology was not identified. Fasting lasted 3.5 ± 3.8 days and parenteral nutrition was indicated in 26.9% of the cases for 10.8 ± 11.3 days. A statistical association with anatomical (p = 0.02) and pharmacological causes (p = 0.01) was found in the recurrent pancreatitis group; no other differences between acute pancreatitis and recurrent pancreatitis groups were observed. The mortality rate was 3.1%, it was not attributable to acute pancreatitis in any cases. Conclusion: Acute pancreatitis is associated with a high frequency of acute recurrent pancreatitis. Severity and complications did not show statistically significant differences in this investigation. Anatomical etiologies were the most relevant cause in this cohort. Fasting time and parenteral nutrition use were relevant. Genetics testing is required in this population.


RESUMO Objetivo: Descrever a epidemiologia e as características clínicas da pancreatite aguda e da pancreatite aguda recorrente em crianças. Métodos: Estudo observacional e retrospectivo com um componente analítico. Os pacientes foram classificados em dois grupos: pancreatite aguda e pancreatite recorrente. A relação com cada parâmetro obtido foi analisada com o teste de qui-quadrado, teste t de Student ou teste U de Mann-Whitney. Resultados: Foram analisados 130 pacientes com pancreatite aguda; pancreatite recorrente foi diagnosticada em 23,8% dos casos. As causas mais frequentes foram anatômicas (29,6%), farmacológicas (19,2%) e biliares (14,6%), embora em 29,2% a etiologia não tenha sido identificada. O jejum durou 3,5 ± 3,8 dias e a nutrição parenteral foi indicada em 26,9% dos casos por 10,8 ± 11,3 dias. Uma associação estatística com causas anatômicas (p = 0,02) e farmacológicas (p = 0,01) foi encontrada no grupo com pancreatite recorrente; não foram observadas outras diferenças entre os grupos pancreatite aguda e pancreatite recorrente. A taxa de mortalidade foi de 3,1% e nenhum caso foi atribuível à pancreatite aguda. Conclusão: A pancreatite aguda está associada à alta frequência de pancreatite aguda recorrente. A gravidade e as complicações não apresentaram diferenças estatísticas nesta investigação. Etiologias anatômicas foram a causa mais relevante nesta coorte. O tempo de jejum e o uso de nutrição parenteral foram relevantes. Testes genéticos são necessários em nossas populações.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Pancreatitis/etiology , Pancreatitis/epidemiology , Pancreatitis/diagnosis , Pancreatitis/therapy , Recurrence , Comorbidity , Acute Disease , Cross-Sectional Studies , Retrospective Studies , Fasting , Parenteral Nutrition , Colombia/epidemiology
8.
Rev. méd. Chile ; 147(8): 1078-1081, ago. 2019. graf
Article in Spanish | LILACS | ID: biblio-1058646

ABSTRACT

Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution.


Subject(s)
Humans , Female , Pregnancy , Young Adult , Pancreatitis/etiology , Pregnancy Complications/etiology , Hypercalcemia/complications , Pancreatitis/surgery , Pancreatitis/diagnostic imaging , Parathyroid Neoplasms/diagnostic imaging , Pregnancy Complications/surgery , Adenoma/diagnostic imaging , Abdominal Pain/etiology , Parathyroidectomy/methods , Treatment Outcome , Cholangiopancreatography, Magnetic Resonance/methods
9.
Rev. Assoc. Med. Bras. (1992) ; 65(7): 965-970, July 2019. tab, graf
Article in English | LILACS | ID: biblio-1013017

ABSTRACT

SUMMARY OBJECTIVE Acute pancreatitis (AP) is an important clinical event with an increased frequency due to increased life expectancy, obesity, and alcohol use. There are some data about the elevation of carbohydrate antigen (CA) 19-9 levels in benign and malignant pancreaticobiliary events in the literature, but in AP they are limited. The aim of this study was to evaluate the CA 19-9 level in patients with AP and determine its relationship according to the cause. METHODS Between 2010-2018, 173 patients evaluated with CA 19-9 levels as well as by standard laboratory tests were included in the study. CA 1 9-9 levels and laboratory findings were compared in patients with pancreatitis due to gallstone (group 1) and metabolic/toxic reasons such as hyperlipidemia, alcohol, or drug use (group 2). RESULTS There were 114 (66%) patients in the group 1 and 59 (34%) patients in the group 2. The majority of patients with high CA 19-9 level were in group 1 (92.1% vs 6.8%). CA 19-9 level, as well as amylase, lipase, AST, ALT and bilirubin levels were found to be statistically higher in patients with AP due to gallstone compared to patients with metabolic/toxic AP. CONCLUSIONS Patients with AP due to gallstone, were found to have a high level of CA 19-9 at admission. Early stage CA 19-9 levels may contribute to standard laboratory tests in the etiology of the disease in patients diagnosed with AP.


RESUMO OBJETIVO A pancreatite aguda (PA) é um evento clínico importante e cada vez mais frequente devido ao aumento da expectativa de vida, obesidade e do consumo de álcool. Existem alguns dados na literatura sobre a elevação dos níveis do antígeno carboidrato (CA) 19-9 em eventos pancreato-biliares benignos e malignos, mas eles são limitados em relação à PA. O objetivo deste estudo foi avaliar o nível de CA 19-9 em pacientes com PA e determinar sua relação com a causa da doença. PACIENTES E MÉTODOS Entre 2010 e 2018, 173 pacientes submetidos a uma avaliação dos níveis de CA 19-9, bem como testes laboratoriais padrão, foram incluídos no estudo. Os níveis de CA 19-9 e os achados laboratoriais foram comparados em pacientes com pancreatite devido a cálculos biliares (grupo 1) e razões metabólicas/tóxicas, como hiperlipidemia, álcool, ou uso de drogas (grupo 2). RESULTADOS Um total de 114 (66%) pacientes foi incluído no grupo 1 e 59 (34%) no grupo 2. A maioria dos pacientes com alto nível de CA 19-9 estavam no grupo 1 (92,1% versus 6,8%). O CA 19-9, bem como os níveis de amilase, lipase, AST, ALT e bilirrubina foram estatisticamente mais altos em pacientes com PA devido a cálculos biliares em comparação àqueles com PA devido a alterações metabólicas/tóxicas. CONCLUSÃO Pacientes com PA devido a cálculos biliares apresentaram um alto nível de CA 19-9 no momento da internação. O nível de CA 19-9 na fase inicial pode contribuir para testes laboratoriais padrão na etiologia da doença em pacientes com diagnóstico de PA.


Subject(s)
Humans , Male , Female , Adult , Aged , Aged, 80 and over , Young Adult , Pancreatitis/etiology , Pancreatitis/metabolism , Gallstones/complications , Gallstones/metabolism , CA-19-9 Antigen/blood , Reference Values , Predictive Value of Tests , Retrospective Studies , ROC Curve , Statistics, Nonparametric , Middle Aged
10.
Medicentro (Villa Clara) ; 23(2): 94-104, abr.-jun. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1002572

ABSTRACT

RESUMEN Introducción: la pancreatitis aguda es una enfermedad muy frecuente que se define como un proceso inflamatorio reversible del tejido pancreático, producido por la activación intraparenquimatosa de enzimas digestivas. Objetivo: determinar los factores pronósticos tempranos en la pancreatitis aguda, de causa biliar y no biliar, asociados a evolución desfavorable. Métodos: se realizó un estudio observacional analítico en pacientes con pancreatitis aguda, atendidos en el Hospital Universitario Clínico-Quirúrgico «Arnaldo Milián Castro¼ (2013 - 2017). Se empleó un muestreo no probabilístico intencional, por criterios de inclusión y exclusión. Resultados: la edad media de los pacientes egresados y con pancreatitis aguda no biliar, fue significativamente menor que la de los fallecidos. Se identificaron como factores de riesgo en la ocurrencia de mortalidad: la edad mayor de 65 años (OR=3,813-IC: 1,451-10,025), el sexo femenino (OR=2,700-IC: 1,044-6,981), la pancreatitis de origen biliar (OR=1,279-IC: 0,321-5,102), la pancreatitis aguda necrótica (OR=7,822-IC: 1,772-34,526), la presencia de derrame pleural (OR=5,929-IC: 1,912-18,386) y un índice de gravedad tomográfica (IGT)> D (OR=2,800-IC: 0,381-20,579). Los resultados de los valores de sensibilidad, especificidad, valor predictivo positivo y negativo de la TGO, y la TGP, en relación a la pancreatitis aguda necrótica hemorrágica, fueron de (37,5 %, 69,7 %, 23,1 % y 82,1%) y (60 %, 83,3 %, 42,9 % y 90,9 %), respectivamente. El área bajo la curva de la TGP fue de 0,790. Conclusiones: se identificaron como factores negativos: la edad mayor de 65, el origen biliar, la pancreatitis aguda necrótica, el derrame pleural y la gravedad tomográfica.


ABSTRACT Introduction: acute pancreatitis is a very common disease that is defined as a reversible inflammatory process of pancreatic tissue, produced by the intraparenchymal activation of digestive enzymes. Objective: to determine the early prognostic factors in acute biliary and non-biliary pancreatitis associated with an unfavorable evolution. Methods: an analytical observational study was performed in patients with acute pancreatitis seen at "Arnaldo Milián Castro" Clinico-Surgical University Hospital from 2013 to 2017. Intentional non-probabilistic sampling was used following inclusion and exclusion criteria. Results: the average age of the discharged patients and patients with acute non-biliary pancreatitis was significantly lower than the average age of the deceased ones. We identified as risk factors in the occurrence of mortality: age over 65 years (OR = 3.813-CI: 1.451-10.025), female gender (OR = 2.700-CI: 1.044-6.981), biliary pancreatitis (OR = 1.279-CI: 0.321-5.102), acute necrotizing pancreatitis (OR = 7.822-CI: 1.772-34.526), the presence of pleural effusion (OR = 5.929-CI: 1.912-18.386) and a computed tomographic severity index (CTSI)> D (OR = 2.800-CI: 0.381-20.579). The results of the values of sensitivity, specificity, positive and negative predictive value of AST and ALT, in relation to acute necrotizing hemorrhagic pancreatitis, were (37.5%, 69.7%, 23.1% and 82.1%) and (60%, 83.3%, 42.9% and 90.9%), respectively. The area under the curve for ALT was 0.790. Conclusions: we identified as negative factors: age over 65, biliary origin, acute necrotizing pancreatitis, pleural effusion and tomographic severity.


Subject(s)
Pancreatitis/etiology , Predictive Value of Tests
11.
J. vasc. bras ; 17(3)jul.-set. 2018. ilus
Article in Portuguese | LILACS | ID: biblio-915990

ABSTRACT

O pseudoaneurisma da artéria esplênica é uma entidade rara, com pouco mais de 150 casos descritos na literatura. A pancreatite é a etiologia mais comum, seguida do trauma. Em contraposição ao aneurisma verdadeiro, esse pseudoaneurisma é frequentemente sintomático, com risco de ruptura de 47% e mortalidade de 90%, quando não tratado. Descrevemos o caso de uma paciente de 48 anos que apresentou hemorragia gastrointestinal associada a pancreatite crônica agudizada. Durante investigação, a endoscopia evidenciou sinais de sangramento recente, e a angiorressonância de abdome observou volumoso pseudoaneurisma da artéria esplênica. Foi submetida a tratamento endovascular com embolização com micromolas, não apresentando novos episódios de sangramento. Atualmente, o tratamento endovascular é efetivo com baixa morbimortalidade e taxas de sucesso de 79-100%, sendo uma técnica viável para pacientes com processo inflamatório abdominal em franca atividade. Realizamos uma revisão das técnicas endovasculares e agentes embolizantes usados para o tratamento dessa patologia


Pseudoaneurysm of the splenic artery is a rare entity, with little more than 150 cases described in the literature. Pancreatitis is the most common etiology, followed by trauma. In contrast with true aneurysms, pseudoaneurysms are frequently symptomatic, with a 47% risk of rupture and 90% mortality if left untreated. We describe the case of a 48-year-old female patient who suffered a gastrointestinal hemorrhage associated with acute-on-chronic pancreatitis. During workup, endoscopy revealed signs of recent bleeding and magnetic resonance angiography of the abdomen showed a large pseudoaneurysm of the splenic artery. The patient underwent endovascular treatment with microcoil embolization and no further bleeding episodes occurred. Endovascular treatment is now an effective option with low morbidity and mortality and success rates in the range of 79-100%, making it a viable technique for patients with active abdominal inflammation. We conducted a review of endovascular techniques and embolization agents used to treat this pathology


Subject(s)
Humans , Female , Middle Aged , Aneurysm, False/surgery , Endovascular Procedures/methods , Hemorrhage , Splenic Artery/surgery , Abdomen , Angiography/methods , Arteriovenous Fistula/surgery , Diagnostic Imaging/methods , Echocardiography/methods , Embolization, Therapeutic/methods , Endoscopy/methods , Magnetic Resonance Spectroscopy/methods , Pancreas/surgery , Pancreatitis/etiology
12.
Arch. argent. pediatr ; 116(2): 308-311, abr. 2018. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-887475

ABSTRACT

La pancreatitis consiste en la inflamación aguda del páncreas, que se caracteriza, clínicamente, por dolor abdominal. Para realizar el diagnóstico, es necesario que se presente la elevación de marcadores bioquímicos, como amilasa o lipasa pancreáticas. Esta afección es la enfermedad pancreática más frecuente tanto en niños como en adultos. Su presentación en la población pediátrica está en aumento y tiene varias etiologías, como infecciones, trauma, intoxicación y enfermedades metabólicas. Entre los mecanismos de trauma, se han descrito maltrato infantil, caídas, trauma con el manubrio de la bicicleta y accidentes de tránsito. En este artículo, se presenta un caso de pancreatitis secundaria a un trauma abdominal con el manubrio de una bicicleta en una paciente de 7 años.


Pancreatitis consists in acute inflammation of the pancreas that is clinically characterized by abdominal pain. To make the diagnosis it is necessary the elevation of biochemical markers like pancreatic amylase or lipase. It is the most frequent pancreatic disease in both children and adults. Its presentation in the pediatric population is increasing and has several etiologies such as: infections, trauma, intoxication and metabolic diseases. Trauma mechanisms have been described: child maltreatment, falls, trauma with the bicycle handle and traffic accidents. In this article, we present a case of pancreatitis secondary to an abdominal trauma with the handle of a bicycle in a patient of 7 years.


Subject(s)
Humans , Female , Child , Pancreas/injuries , Pancreatitis/etiology , Abdominal Injuries/complications , Acute Disease
15.
Rev. chil. cir ; 69(6): 459-466, dic. 2017. tab, graf, ilus
Article in Spanish | LILACS | ID: biblio-899637

ABSTRACT

Resumen Objetivo: Las anomalías pancreáticas del desarrollo son un espectro de variaciones anatómicas, entre las que se destaca el páncreas divisum; su asociación con la pancreatitis aguda continúa siendo controversial. Materiales y métodos: En primer término se realizó una investigación no experimental de corte transversal sobre 100 piezas duodenopancreáticas cadavéricas y en segunda instancia se analizó el reporte de caso de un paciente con colestasis extrahepática y pancreatitis aguda asociadas a la portación de páncreas divisum. El objetivo fue determinar la prevalencia del sistema descompresivo pancreático. Resultados: Existe diferencia estadísticamente significativa entre las dimensiones del conducto pancreático accesorio y su relación con la permeabilidad. En cuanto a la volumetría pancreática, la sección correspondiente al tercio superior cefálico, cuello, cuerpo y cola del órgano registró una dimensión media de 21,99 cm3, mientras que la sección de los dos tercios cefálicos restantes fue de 8,17 cm3. Simultáneamente, el paciente reportado presentó cuadro clínico de pancreatitis con amilasa de 280 UI/l y lipasa de 173 UI/l asociado a colestasis. Al segundo día de internación se realizó colangiopancreatografía retrógrada endoscópica con papilotomía duodenal mayor y extracción de múltiples cálculos coledocianos, evidenciando un páncreas divisum completo. Discusión: El caso expuesto exhibe que la pancreatitis, en presencia de páncreas divisum, tendría la denominación de una pancreatitis ventral subclínica. Conclusión: El páncreas divisum sería un predictor determinante de pancreatitis aguda al perder el mecanismo descompresivo protector pancreático.


Abstract Purpose: Pancreatic developmental anomalies are a spectrum of anatomical variations, including the pancreas divisum, where its association with acute pancreatitis continues being controversial. Materials and methods: Firstly, a non-experimental cross-sectional study was carried out on one hundred cadaveric duodenpancreatic pieces, and secondly was analyzed the case report of a patient with extrahepatic cholestasis and acute pancreatitis associated with pancreas divisum. The objective was to determinate the prevalence of the decompressive pancreatic system. Results: There is a statistically significant difference between the dimensions of the accessory pancreatic duct and its relation with the permeability. In terms of pancreatic volumetry, the section corresponding to the upper third cephalic, neck, body and tail of the organ registers an average dimension of 21.99 cm3, while the section of the last two thirds cephalic was 8.17 cm3. Simultaneously, the patient reported presented a pancreatitis with amylase 280 UI/l, lipase 173 UI/l, associated with cholestasis. On the second day of hospitalization, endoscopic retrograde cholangiopancreatography was performed with a greater duodenal papillotomy and extraction of multiple common bile duct stones, evidencing a complete pancreas divisum. Discussion: The exposed case shows that pancreatitis, in presence of pancreas divisum, would have the denomination of a subclinical ventral pancreatitis. Conclusion: The pancreas divisum would be a predictor of acute pancreatitis by losing the decompressive pancreatic protective mechanism.


Subject(s)
Humans , Pancreas/abnormalities , Pancreatitis/etiology , Cadaver , Acute Disease , Cross-Sectional Studies
16.
Medicina (B.Aires) ; 77(6): 506-508, dic. 2017. ilus
Article in Spanish | LILACS | ID: biblio-894530

ABSTRACT

La malformación arterio-venosa (MAV) en el páncreas es una anomalía anatómica poco frecuente que puede ser causa de pancreatitis aguda. Presentamos el caso de un paciente de 46 años cuyo diagnóstico se sospechó por los hallazgos de la tomografía computarizada con contraste endovenoso y por resonancia magnética y se confirmó mediante una arteriografía del tronco celíaco y de la arteria mesentérica superior. El tratamiento recibido fue por vía endovascular, aunque la otra opción válida para el tratamiento de esta enfermedad es la resección quirúrgica. El objetivo de esta comunicación es presentar un caso de pancreatitis aguda por MAV tratada por vía endovascular.


Arteriovenous malformation in the pancreas is a rare anatomic abnormality that may produce acute pancreatitis. The diagnosis was suspected by computed tomography with intravenous contrast and by magnetic resonance imaging and it was confirmed by arteriography of the celiac trunk and superior mesenteric artery. The treatment received was endovascular, although the other valid option for the treatment of this disease is the surgical resection. The objective of this communication is to present a case of acute pancreatitis due to arteriovenous malformation treated by endovascular approach.


Subject(s)
Humans , Male , Middle Aged , Pancreas/blood supply , Pancreatitis/etiology , Arteriovenous Malformations/complications , Pancreatitis/surgery , Pancreatitis/diagnostic imaging , Arteriovenous Malformations/diagnostic imaging , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Acute Disease , Treatment Outcome , Endovascular Procedures
17.
Rev. chil. cir ; 69(3): 259-263, jun. 2017. ilus
Article in Spanish | LILACS | ID: biblio-844370

ABSTRACT

Introducción: Los pólipos gástricos adenomatosos son poco frecuentes y generalmente se encuentran en el examen endoscópico de rutina. La intususcepción gastroduodenal es una complicación poco frecuente de los pólipos gástricos y ha sido raramente descrita como una causa de pancreatitis aguda. Caso clínico: Presentamos el caso de un varón de 68 años el cual ingresa de urgencia con dolor abdominal, náuseas y vómitos catalogados en un inicio como pancreatitis aguda de etiología biliar; incidentalmente se descubre un pólipo gástrico pediculado intususceptado a duodeno como causa de la pancreatitis aguda. Se realizó tratamiento endoscópico de urgencia y tratamiento definitivo con cirugía abierta.


Introduction: Adenomatous gastric polyps are uncommon and are usually found in the routine endoscopic examination. Gastroduodenal intussusception is a rare complication of those gastric polyps and has rarely been described as a cause of acute pancreatitis. Case report: We present the case of a 68 year old man who admitted to emergency with abdominal pain, nausea and vomiting initially classified as acute biliary pancreatitis etiology; a pedunculated gastric polyp intussuscepted into duodenum as a cause of acute pancreatitis was incidentally discovered, emergency endoscopic treatment and definitive treatment with open surgery was performed.


Subject(s)
Humans , Male , Aged , Intussusception/complications , Pancreatitis/etiology , Acute Disease , Intestinal Polyps/complications , Intussusception/diagnostic imaging , Intussusception/surgery , Pancreatitis/diagnostic imaging , Stomach Neoplasms/complications
18.
Arch. endocrinol. metab. (Online) ; 61(2): 198-201, Mar.-Apr. 2017. tab
Article in English | LILACS | ID: biblio-838424

ABSTRACT

SUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Pancreatitis/etiology , Pancreatitis/drug therapy , Heparin/therapeutic use , Hypertriglyceridemia/complications , Hypoglycemic Agents/therapeutic use , Insulin/therapeutic use , Anticoagulants/therapeutic use , Fenofibrate/therapeutic use , Triglycerides/blood , Hypertriglyceridemia/drug therapy , Acute Disease , Reproducibility of Results , Treatment Outcome , Drug Therapy, Combination , Lipoprotein Lipase/therapeutic use , Hypolipidemic Agents/therapeutic use
19.
Egyptian Journal of Hospital Medicine [The]. 2017; 67 (2): 742-748
in English | IMEMR | ID: emr-188464

ABSTRACT

Background: Endoscopic sphincterotomy [EST] combined with balloon catheters and/or baskets are the routine endoscopic techniques for stone extraction in the great majority of patients. Whereas large common bile duct [CBD] stones are treated conventionally with mechanical lithotripsy, large balloon papillary dilation after endoscopic sphincterotomy [ELPBD] represents the onset of an era in large CBD stone extraction and the management of [impaction]. That is because it seems effective, inexpensive, less traumatic, safe and easy method that does not require sophisticated apparatus and can be performed widely by skillful endoscopists. Studies comparing the efficacy and safety of EPLBD with EST have reported mixed outcomes. The aim of the study to compare the success and complications rates between endoscopic papillary balloon dilation and endoscopic sphincterotomy for enlargement of papillary opening during endoscopic removal of common bile duct stones


Methods: Randomized prospective comparative study was conducted on seventy four patients with CBD stone[s], subjective to therapeutic ERCP procedures for endoscopic extraction of common CBD[s]


The enrolled patients were randomly divided into two groups according to the maneuver for dilate the papillary orifice into: Group I: Thirty one patients underwent EPLBD technique combined with balloon catheters and/or baskets for stone extraction. Group II: Forty three patients underwent EST combined with balloon catheters and/or baskets, which is considered as conventional endoscopic technique for stone extraction in the great majority of patients


Results: Complete extraction CBD stones among the patients of groupl; EPLBD was effective for clearance of [92.5%] of CBD stones in patients with the stone sized < 1cm and in [83%] of patients with stone size > 1cm, [overall clearance rate=87%]


Overall adverse effects of patients of groupl was [29%] as mild self-limiting post ERCP pain occurred in [9.6%] and mild intra- procedure bleeding occurred in [9.6%], whereas more serious complication as melena which occurred in [3.2%], and mild pancreatitis occurred in [6.4%]. Whereas complete CBD stones clearance among the patients of group 2; EST was effective in [96%] of patients with the stone sized < 1 cm, while stone clearance occurred in [56%] in patient with stone size> 1cm, [overall clearance rate=79%]. Overall adverse effects of patients of group 2 was [18.5%] as mild self-limiting post ERCP pain occurred in [7%] and mild intra-procedure bleeding occurred in [4.6%], whereas more serious complications as mild pancreatitis developed in [4.6%], and post ERCP cholangitis in [2.3%] The comparison between the two groups regarding the extraction of CBD stones revealed combination of papillary large balloon dilation after EST is not required in patients whose the CBD stone size < 1 cm. Whereas the clearance rate of CBD stones in the patients with stone size > 1cm among the group 1 was [83%] which better than among the group 2 which was [56%] with nearly statistical difference [P value=0.07]


Conclusion: Conventional EST is an effective method for removal of common bile duct stones < 1 cm in diameter whereas the use of large papillary balloon dilation after endoscopic sphincterotomy improve the clearance rate of bile duct stones> 1cm which is difficult to be extracted by conventional sphincterotomy and extraction devices. Endoscopic papillary large balloon dilation is an adjunctive tool to endoscopic sphincterotomy for removing large or difficult CBD stones


Subject(s)
Humans , Balloon Enteroscopy , Sphincterotomy, Endoscopic , Lithotripsy , Randomized Controlled Trials as Topic , Pancreatitis/etiology , Cholangiopancreatography, Endoscopic Retrograde , Egypt
20.
Rev. Soc. Bras. Med. Trop ; 49(5): 656-659, Sept.-Oct. 2016. tab, graf
Article in English | LILACS | ID: lil-798125

ABSTRACT

Abstract Dengue infection can have spectrum of manifestations, often with an unpredictable clinical progression and outcome. There have been increasing reports of atypical manifestations. Abdominal pain or tenderness and persistent vomiting (warning signs) are present in the majority of cases with severe dengue prior to clinical deterioration. We report a 10-year-old child who presented with fever, persistent vomiting, and abdominal pain. A diagnosis of acute pancreatitis was made. This is a very infrequently reported complication of dengue hemorrhagic fever.


Subject(s)
Humans , Female , Child , Pancreatitis/etiology , Severe Dengue/complications , Pancreatitis/diagnosis , Acute Disease , Severe Dengue/diagnosis
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