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1.
Rev. Nac. (Itauguá) ; 13(2): 18-28, DICIEMBRE, 2021.
Article in Spanish | LILACS, BDNPAR | ID: biblio-1344187

ABSTRACT

RESUMEN Introducción: la pandemia de COVID-19 ha incrementado los casos de ansiedad y causado grandes modificaciones en la forma de prestar atención médica. Objetivo: describir las características epidemiológicas de los trastornos de ansiedad atendidos a través de telepsiquiatría en un Hospital Universitario. Metodología: estudio observacional, descriptivo, de corte transversal. Se realizó un muestreo no aleatorio intencional. Se utilizaron fichas electrónicas de pacientes tratados en el Servicio de Psiquiatría del Hospital de Clínicas, Paraguay, entre febrero y mayo de 2021. Se realizó estadística descriptiva de todas las variables. Se calcularon medidas de tendencia central y dispersión para las variables cuantitativas. Las cualitativas se resumieron en frecuencias y porcentajes. Resultados: el análisis incluyó 804 pacientes. El 71,5 % (575) de los pacientes procedían del ámbito rural. De todos los pacientes con diagnóstico de algún trastorno de ansiedad (20,49 % n = 165), el 69,1 % (114) correspondían a mujeres y el 49,7 % (82) presentaron trastorno de pánico (ansiedad paroxística episódica), 28,5 % (47) fueron diagnosticados con trastorno de ansiedad generalizada, y 21,8 % (36) tuvieron un trastorno de ansiedad no especificado. Conclusión: más del 20 % de los pacientes que consultaron a través de la modalidad de telepsiquiatría presentó algún cuadro del espectro ansioso. La presentación de casos se dio tanto en el ámbito rural como en el urbano y de preferencia en mujeres. El trastorno de pánico emergió como el trastorno de más alta frecuencia en la población accesible, representando casi la mitad de todos los casos de ansiedad diagnosticados.


ABSTRACT Introduction: the COVID-19 pandemic has increased anxiety cases and caused big modifications in the way medical care is provided. Objective: to describe the epidemiological characteristics of anxiety disorders treated through telepsychiatry in a University Hospital. Methodology: observational, descriptive, cross-sectional study. A non-random purposive sampling was performed. Electronic records of patients treated in the Psychiatry Department of the "Hospital de Clínicas", Paraguay, between February and May 2021 were used. Descriptive statistics were performed for all variables. Measures of central tendency and dispersion were calculated for quantitative variables. Qualitative variables were summarized in frequencies and percentages. Results: the analysis included 804 patients. Out of the patients, 71,5 % (575) were from rural areas. Out of all patients diagnosed with an anxiety disorder (20,49 % n = 165), 69,1 % (114) were female and 49,7 % (82) had panic disorder (episodic paroxysmal anxiety), 28,5 % (47) were diagnosed with generalized anxiety disorder, and 21,8 % (36) had an unspecified anxiety disorder. Conclusion: more than 20 % of the patients who consulted through the telepsychiatry modality presented with an anxiety spectrum disorder. Cases were presented in both rural and urban areas and preferably in females. Panic disorder emerged as the most frequent disorder in the accessible population, representing almost half of all diagnosed anxiety cases.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Anxiety/epidemiology , Anxiety Disorders/epidemiology , Pandemics , Telepsychiatry , Paraguay/epidemiology , Mental Health/trends , Panic Disorder/epidemiology , Remote Consultation/methods , Age and Sex Distribution , COVID-19
3.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 43(1): 6-11, Jan.-Feb. 2021. tab
Article in English | LILACS | ID: biblio-1153272

ABSTRACT

Objective: To investigate the course of panic disorder and its demographic and clinical correlates during the postpartum period. Methods: Data were collected from 38 consecutive postpartum women diagnosed with panic disorder. Psychiatric assessments were carried out on the first day after delivery and at 6-8 weeks postpartum. During the first assessment, the Panic and Agoraphobia Scale (PAS), Hospital Anxiety and Depression Scale (HADS), Coping Orientation to Problems Experienced (COPE), Multidimensional Scale of Perceived Social Support (MSPSS), and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) were administered to the participants. PAS was also administered at the second assessment. Results: The mean PAS score reduced significantly from baseline to the second assessment. Logistic regression analysis indicated that a shorter duration of panic disorder independently predicted a ≥ 50-point decrease in the severity of panic symptoms during the postpartum period. Conclusion: These findings suggest that patients with a short duration of illness may experience significant alleviation in the severity of panic symptoms during the postpartum period.


Subject(s)
Humans , Female , Panic Disorder/epidemiology , Temperament , Agoraphobia , Postpartum Period
6.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 42(4): 420-430, July-Aug. 2020. tab
Article in English | LILACS | ID: biblio-1132104

ABSTRACT

Panic disorder (PD) pathophysiology is very heterogeneous, and the discrimination of distinct subtypes could be very useful. A subtype based on respiratory symptoms is known to constitute a specific subgroup. However, evidence to support the respiratory subtype (RS) as a distinct subgroup of PD with a well-defined phenotype remains controversial. Studies have focused on characterization of the RS based on symptoms and response to CO2. In this line, we described clinical and biological aspects focused on symptomatology and CO2 challenge tests in PD RS. The main symptoms that characterize RS are dyspnea (shortness of breath) and a choking sensation. Moreover, patients with the RS tended to be more responsive to CO2 challenge tests, which triggered more panic attacks in this subgroup. Future studies should focus on discriminating respiratory-related clusters and exploring psychophysiological and neuroimaging outcomes in order to provide robust evidence to confirm RS as a distinct subtype of PD.


Subject(s)
Humans , Carbon Dioxide/blood , Panic Disorder/physiopathology , Pulmonary Ventilation/physiology , Hyperventilation/physiopathology , Psychopathology , Psychophysiology , Panic Disorder/diagnosis , Panic Disorder/psychology , Dyspnea/etiology , Hyperventilation/diagnosis , Hyperventilation/psychology
7.
Arch. Clin. Psychiatry (Impr.) ; 47(1): 19-24, Jan.-Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1088743

ABSTRACT

Abstract Background Sleep disorders are common in psychiatric diseases. Panic disorder (PD) and generalized anxiety disorder (GAD) are two major anxiety disorders that are associated with sleep disorders. Objective We hypothesized that poor sleep quality continues in PD and GAD during remission. Therefore, in this study we aimed to compare the sleep quality of patients with PD and GAD to that of healthy controls. Methods The study included patients with PD (n = 42) and GAD (n = 40) who had been in remission for at least 3 months and healthy control volunteers (n = 45). The patients were administered the Pittsburgh Sleep Quality Index (PSQI), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). Results The total PSQI scores of the GAD group were significantly increased in comparison to those of the PD (p = 0.009) and control (p < 0.001) groups. The rate of poor sleep quality in GAD during remission (77.5%) was greater than that of the PD (47.6%) and control (51.1%) groups (p = 0.011). Discussion GAD is a chronic and recurrent disease. In this study, it was found that the deterioration in sleep quality of patients with GAD may continue during remission. In the follow-up and treatment of patients, it is appropriate to question about sleep symptoms and to plan interventions according to these symptoms.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Young Adult , Anxiety Disorders/complications , Panic Disorder/complications , Sleep Initiation and Maintenance Disorders/etiology , Anxiety Disorders/drug therapy , Anxiety Disorders/epidemiology , Tobacco Use Disorder/complications , Remission Induction , Case-Control Studies , Chronic Disease , Cross-Sectional Studies , Follow-Up Studies , Panic Disorder/drug therapy , Panic Disorder/epidemiology , Serotonin Uptake Inhibitors/therapeutic use , Disease-Free Survival , Serotonin and Noradrenaline Reuptake Inhibitors/therapeutic use , Sleep Initiation and Maintenance Disorders/epidemiology
9.
Trends psychiatry psychother. (Impr.) ; 41(4): 387-393, Oct.-Dez. 2019. tab
Article in English | LILACS | ID: biblio-1059178

ABSTRACT

Abstract Objective To identify which clinical features and personality traits are associated with quality of life (QoL) in panic disorder (PD) patients. Methods This was a cross-sectional study with PD patients. The brief version of the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF) and the Big Five Inventory (BFI) were used to assess QoL and personality traits respectively. The strength of correlations was measured with Pearson's, Spearman's, and point-biserial correlation coefficients. We also performed multiple linear regressions, considering sociodemographic data and scores from clinical scales as independent variables and QoL scores as dependent variables. Results A total of 98 patients were evaluated. Depressive symptoms had a strong negative correlation with QoL and, to a lesser extent, panic and anxiety symptoms were also negatively correlated with QoL. While consciousness, extraversion, and agreeableness had mild positive correlations with QoL, neuroticism had a strong negative correlation. Conclusion Symptoms of depression, anxiety, and panic seem to have a negative impact on the QoL of PD patients. Personality traits, especially neuroticism, may also influence QoL in these patients.


Resumo Objetivo Identificar quais características clínicas e traços de personalidade são mais associados à qualidade de vida (QdV) em pacientes com transtorno de pânico (TP). Métodos Este foi um estudo transversal, realizado em pacientes com TP. A versão breve do Questionário de Qualidade de Vida da Associação Mundial de Saúde (World Health Organization Quality of Life Questionnaire - WHOQOL-BREF) e o Inventário dos Cinco Grande Fatores (Big Five Inventory - BFI) foram utilizados para avaliar QdV e traços de personalidade, respectivamente. A força de associação foi medida através da correlação de Pearson, de Spearman ou ponto bisserial. Foram também realizadas regressões lineares múltiplas, considerando os dados sociodemográficos e escores obtidos nas escalas clínicas como variáveis independentes, e os escores de QdV como variáveis dependentes. Resultados Um total de 98 pacientes foram avaliados. Sintomas depressivos apresentaram uma forte relação negativa com QdV; em menor intensidade, sintomas de TP e ansiosos também se correlacionaram com QdV. Nos domínios de personalidade, enquanto conscienciosidade, extroversão e amabilidade apresentaram uma leve correlação positiva com QdV, neuroticismo apresentou forte correlação negativa. Conclusão Sintomas depressivos, ansiosos e de TP parecem ter forte impacto negativo na QdV dos pacientes com TP. Traços de personalidade, principalmente neuroticismo, podem influenciar QdV nesses pacientes.


Subject(s)
Humans , Male , Female , Adult , Personality , Quality of Life/psychology , Panic Disorder/psychology , Personality Inventory , Psychiatric Status Rating Scales , Cross-Sectional Studies , Surveys and Questionnaires
10.
Article in English | WPRIM | ID: wpr-765014

ABSTRACT

BACKGROUND: Panic disorder (PD) and major depressive disorder (MDD) can occur concurrently, despite different clinical manifestations. Because MDD and PD patients tend to have more complicated conditions, understanding the co-occurrence and pattern of these conditions is important. Here, we investigated the influence of PD and MDD on each other, with respect to time interval. METHODS: Data from three national representative surveys were pooled (total 18,807 respondents), and the age of onset (AOO) of PD and MDD was analyzed. We performed Kaplan-Meier analysis to estimate separate survival functions, using the AOO of MDD and PD as the outcome. To understand the temporal effect of other disorders, we used a Cox proportional hazard model to estimate the hazard ratios for the onset of MDD/PD with other comorbidities as time-dependent covariates. RESULTS: PD elevated the risk of subsequent MDD by 1.5-fold, whereas MDD elevated the risk of subsequent PD by 3.8-fold. The effect of such an elevation risk was significant for up to 2 years. CONCLUSION: The results revealed a bidirectional relationship between MDD and PD. Each disease represents a risk of a subsequent occurrence of the other, which lasts for a considerable duration.


Subject(s)
Age of Onset , Comorbidity , Depressive Disorder, Major , Humans , Kaplan-Meier Estimate , Korea , Panic Disorder , Panic , Proportional Hazards Models
11.
Article in English | WPRIM | ID: wpr-763542

ABSTRACT

Panic disorder (PD) being one of the most intensively investigated anxiety disorders is considered a heterogeneous psychiatric disease which has difficulties with early diagnosis. The disorder is recurrent and usually associated with low remission rates and high rates of relapse which may exacerbated social and quality of life, causes unnecessary cost and increased risk for complication and suicide. Current pharmacotherapy for PD are available but these drugs have slow therapeutic onset, several side effects and most patients do not fully respond to these standard pharmacological treatments. Ongoing investigations indicate the need for new and promising agents for the treatment of PD. This article will cover the importance of immediate and proper treatment, the gap in the current management of PD with special emphasis on pharmacotherapy, and evidence regarding the novel anti-panic drugs including the drugs in developments such as metabotropic glutamate (mGlu 2/3) agonist and levetiracetam. Preliminary results suggest the anti-panic properties and the efficacy of duloxetine, reboxetine, mirtazapine, nefazodone, risperidone and inositol as a monotherapy drug. Apart for their effectiveness, the aforementioned compounds were generally well tolerated compared to the standard available pharmacotherapy drugs, indicating their potential therapeutic usefulness for ambivalent and hypervigilance patient. Further strong clinical trials will provide an ample support to these novel compounds as an alternative monotherapy for PD treatment-resistant patient.


Subject(s)
Antidepressive Agents , Antipsychotic Agents , Anxiety , Anxiety Disorders , Drug Therapy , Duloxetine Hydrochloride , Early Diagnosis , Glutamic Acid , Humans , Inositol , Panic Disorder , Panic , Quality of Life , Recurrence , Risperidone , Suicide
12.
Article in English | WPRIM | ID: wpr-741924

ABSTRACT

No abstract available.


Subject(s)
Panic Disorder , Panic
13.
Article in English | WPRIM | ID: wpr-741923

ABSTRACT

To conceptualize a novel bio-psychosocial-behavioral treatment model of panic disorder (PD), it is necessary to completely integrate behavioral, psychophysiological, neurobiological, and genetic data. Molecular genetic research on PD is specifically focused on neurotransmitters, including serotonin, neuropeptides, glucocorticoids, and neurotrophins. Although pharmacological interventions for PD are currently available, the need for more effective, faster-acting, and more tolerable pharmacological interventions is unmet. Thus, glutamatergic receptor modulators, orexin receptor antagonists, corticotrophin-releasing factor 1 receptor antagonists, and other novel mechanism-based anti-panic therapeutics have been proposed. Research on the neural correlates of PD is focused on the dysfunctional “cross-talk” between emotional drive (limbic structure) and cognitive inhibition (prefrontal cortex) and the fear circuit, which includes the amygdala-hippocampus-prefrontal axis. The neural perspective regarding PD supports the idea that cognitive-behavioral therapy normalizes alterations in top-down cognitive processing, including increased threat expectancy and attention to threat. Consistent with the concept of “personalized medicine,” it is speculated that Research Domain Criteria can enlighten further treatments targeting dysfunctions underlying PD more precisely and provide us with better definitions of moderators used to identify subgroups according to different responses to treatment. Structuring of the “negative valence systems” domain, which includes fear/anxiety, is required to define PD. Therefore, targeting glutamate- and orexin-related molecular mechanisms associated with the fear circuit, which includes the amygdala-hippocampus-prefrontal cortex axis, is required to define a novel bio-psychosocial-behavioral treatment model of PD.


Subject(s)
Glucocorticoids , Molecular Biology , Nerve Growth Factors , Neuropeptides , Neurotransmitter Agents , Orexin Receptor Antagonists , Panic Disorder , Panic , Serotonin
14.
Article in English | WPRIM | ID: wpr-741922

ABSTRACT

The core concept for pathophysiology in panic disorder (PD) is the fear network model (FNM). The alterations in FNM might be linked with disturbances in the autonomic nervous system (ANS), which is a common phenomenon in PD. The traditional FNM included the frontal and limbic regions, which were dysregulated in the feedback mechanism for cognitive control of frontal lobe over the primitive response of limbic system. The exaggerated responses of limbic system are also associated with dysregulation in the neurotransmitter system. The neuroimaging studies also corresponded to FNM concept. However, more extended areas of FNM have been discovered in recent imaging studies, such as sensory regions of occipital, parietal cortex and temporal cortex and insula. The insula might integrate the filtered sensory information via thalamus from the visuospatial and other sensory modalities related to occipital, parietal and temporal lobes. In this review article, the traditional and advanced FNM would be discussed. I would also focus on the current evidences of insula, temporal, parietal and occipital lobes in the pathophysiology. In addition, the white matter and functional connectome studies would be reviewed to support the concept of advanced FNM. An emerging dysregulation model of fronto-limbic-insula and temporooccipito-parietal areas might be revealed according to the combined results of recent neuroimaging studies. The future delineation of advanced FNM model can be beneficial from more extensive and advanced studies focusing on the additional sensory regions of occipital, parietal and temporal cortex to confirm the role of advanced FNM in the pathophysiology of PD.


Subject(s)
Autonomic Nervous System , Connectome , Frontal Lobe , Limbic System , Neuroimaging , Neurotransmitter Agents , Occipital Lobe , Panic Disorder , Panic , Parietal Lobe , Rabeprazole , Temporal Lobe , Thalamus , White Matter
15.
Article in English | WPRIM | ID: wpr-741921

ABSTRACT

OBJECTIVE: Classifying mental disorders on the basis of objective makers might clarify their aetiology, help in making the diagnosis, identify “at risk” individuals, determine the severity of mental illness, and predict the course of the disorder. This study aims to review biological and clinical markers of panic disorder (PD). METHODS: A computerized search was carried out in PubMed and Science Direct using the key words: “marker/biomarker/clinical marker/neurobiology/staging” combined using Boolean AND operator with “panic.” In addition, the reference lists from existing reviews and from the articles retrieved were inspected. Only English language papers published in peer-reviewed journals were included. RESULTS: Structural changes in the amygdala, hippocampus, cerebral blood level in the left occipital cortex, serotonin 5-TH and noradrenergic systems activation, aberrant respiratory regulation, hearth rate variability, blood cells and peripheral blood stem cells, hypothalamic–pituitary–adrenal axis dysregulation were identified as potential candidate biomarkers of PD. Staging was identified as clinical marker of PD. According to the staging model, PD is described as follows: prodromal phase (stage 1); acute phase (stage 2); panic attacks (stage 3); chronic phase (stage 4). CONCLUSION: The clinical utility, sensitivity, specificity, and the predictive value of biomarkers for PD is still questionable. The staging model of PD might be a valid susceptibility, diagnostic, prognostic, and predictive marker of PD. A possible longitudinal model of biological and clinical markers of PD is proposed.


Subject(s)
Amygdala , Biomarkers , Blood Cells , Diagnosis , Hippocampus , Mental Disorders , Occipital Lobe , Panic Disorder , Panic , Prodromal Symptoms , Sensitivity and Specificity , Serotonin , Stem Cells
16.
Article in English | WPRIM | ID: wpr-741920

ABSTRACT

BACKGROUND: Internet-delivered psychological treatments have been suggested as a chance to expand the access to professional help. However, little is known about the usefulness of different support formats and approaches of digital treatments for panic disorder among clinicians. OBJECTIVE: This narrative review aimed to explore the recent evidence base on the efficacy and acceptability of different internet-delivered treatments for adults with panic disorder. METHODS: A systematic search in electronic databases (Pubmed/Medline, PSYNDEX) and a hand search were performed to identify articles on randomized controlled trials published within the past five years (2012/12/10–2017/12/12) in English peer-reviewed journals. RESULTS: Eight studies (1,013 participants) involving 10 interventions met the inclusion criteria. Nine interventions were primarly based on Cognitive Behavioral Therapy principles. Most interventions were effective, when compared to a control condition (6 of 8 comparisons). Minimal guidance was associated with improved outcomes in one study and adherence in two studies (3 comparisons). Furthermore, no differences were found based on treatment approach (2 comparisons). Regarding acceptability, the attrition rates were moderate to high, ranging from 9.8% to 42.1% of randomized participants. Adherence rates also varied largely (7.8–75%), whereas participant satisfaction of program completers was assessed overall high (5 studies). CONCLUSION: Diverse effective internet-delivered treatments are available for the self-management of panic symptoms. Especially selfguided and transdiagnostic Cognitive Behavioral Therapy approaches appear being efficient options for the dissemination in routine care. However, due to the limited evidence base, further efforts are required to improve the actual uptake of internet-delivered treatments and identify moderators of outcomes.


Subject(s)
Adult , Anxiety Disorders , Cognitive Behavioral Therapy , Hand , Humans , Internet , Panic Disorder , Panic , Self Care , Telemedicine
17.
Article in English | WPRIM | ID: wpr-741919

ABSTRACT

OBJECTIVE: Treatment for panic disorder (PD) have evolved, although there is still a strong unmet need for more effective and tolerable options. The present study summarizes and discusses recent evidence regarding the pharmacological and neuromodulatory treatment of PD. METHODS: MEDLINE, Cochrane Library, PsycINFO and Thomson Reuters’s Web of Science were searched for clinical trials published between 2010 and 2018. We included all prospective experimental studies including randomized controlled trials (RCT) and other clinical trials with more than 10 patients. RESULTS: Only 11 articles met the inclusion criteria, including 4 RCT, 3 open clinical trials and 5 comparative clinical trials. RCT demonstrated efficacy of transcranial magnetic stimulation (TMS) in only one of two trials. Neither pindolol nor d-fenfluramine were effective in blocking flumazenil-induced panic attacks. Augmentation with quetiapine was not superior to placebo. Open trials indicated that escitalopram, vortioxetine and TMS may be effective. Comparative trials did not demonstrate superiority from any drug, but confirmed tranylcypromine, paroxetine, clonazepam and alprazolam as effective options. CONCLUSION: The current study confirmed the efficacy of tranylcypromine, paroxetine, clonazepam, alprazolam and escitalopram. Vortioxetine and TMS, with duration of 4 or more weeks, also seems to be effective. Quetiapine, pindolol and d-fenfluramine were not considered effective compounds.


Subject(s)
Alprazolam , Citalopram , Clonazepam , Humans , Panic Disorder , Panic , Paroxetine , Pindolol , Prospective Studies , Quetiapine Fumarate , Transcranial Magnetic Stimulation , Tranylcypromine
18.
Article in Korean | WPRIM | ID: wpr-786251

ABSTRACT

OBJECTIVES: The objective of this study is to investigate differences in clinical characteristics between female panic disorder (PD) patients with abortion history (PD+A) and without abortion history (PD−A).METHODS: We examined data from 341 female patients diagnosed with PD. We divided the patients with PD into PD+A (82 patients) and PD−A (259 patients) to compare demographic and clinical characteristics. The following instruments were applied : stress coping strategies, NEO-neuroticism, the Anxiety Sensitivity Index-Revised (ASI-R), the Albany Panic and Phobia Questionnaire (APPQ), the Beck Depression Inventory, the Beck Anxiety Inventory (BAI) and the Sheehan Disability Scale.RESULTS: Compared to the PD−A, the PD+A group showed no significant difference in coping strategies. However, significantly higher scores in neuroticism, the ASI-R, the APPQ and the BAI were observed. In terms of health-related disability, the PD+A group did not show significant difference.CONCLUSIONS: Our results suggest that the PD+A group may differ from the PD−A group in trait markers such as neuroticism and anxiety sensitivity, and abortion history may be associated with panic-related symptom severity. Our study suggests that further consideration is needed on such clinical characteristics in PD patients with abortion history.


Subject(s)
Abortion, Induced , Anxiety , Depression , Female , Humans , Panic Disorder , Panic , Phobic Disorders
19.
Psychiatry Investigation ; : 249-253, 2019.
Article in English | WPRIM | ID: wpr-760911

ABSTRACT

“Comfort women” are survivors of sexual slavery by the Imperial Japanese Army during World War II, who endured extensive trauma including massive rape and physical torture. While previous studies have been focused on the trauma of the survivors themselves, the effects of the trauma on the offspring has never been evaluated before. In this article, we reviewed the first study on the offspring of former “comfort women” and aimed to detect the evidence of transgenerational transmission of trauma. In-depth psychiatric interviews and the Structured Clinical Interview for DSM-5 Axis I Disorders were conducted with six offspring of former “comfort women.” Among the six participants, five suffered from at least one psychiatric disorder including major depressive disorder, panic disorder, posttraumatic stress disorder, adjustment disorder, insomnia disorder, somatic symptom disorder, and alcohol use disorder. Participants showed similar shame and hyperarousal symptoms as their mothers regarding stimuli related to the “comfort woman” issue. Increased irritability, problems with aggression control, negative worldview, and low self-esteem were evident in the children of mothers with posttraumatic stress disorder. Finding evidence of transgenerational transmission of trauma in offspring of “comfort women” is important. Future studies should include more samples and adopt a more objective method.


Subject(s)
Adjustment Disorders , Aggression , Asians , Child , Depressive Disorder, Major , Humans , Methods , Military Personnel , Mothers , Panic Disorder , Rape , Shame , Enslavement , Sleep Initiation and Maintenance Disorders , Stress Disorders, Post-Traumatic , Survivors , Torture , World War II
20.
Rio de Janeiro; s.n; 2019. 105 f p. tab.
Thesis in Portuguese | LILACS | ID: biblio-1048639

ABSTRACT

O papel das reações vivenciadas durante experiências traumáticas tem sido alvo de interesse nos estudos sobre etiologia e prognóstico do transtorno de estresse pós-traumático. Essa tese avaliou a estrutura dimensional do instrumento mais utilizado para mensurar a dissociação peritraumática, o Peritraumatic Dissociative Experience Questionnaire (PDEQ). Adicionalmente, desenvolveu-se e avaliou-se as propriedades psicométricas do instrumento Peritraumatic Reactions Questionnaire (PTRQ), proposto para mensurar as três principais reações peritraumáticas (RP) no contexto do TEPT: dissociação peritraumática (DP), imobilidade tônica peritraumática (ITP) e reações físicas peritraumáticas (RFP). Os dados utilizados são originários de um estudo transversal realizado entre junho de 2007 e julho 2008 com amostras representativas da população acima de 15 anos das duas maiores cidades brasileiras. A amostra foi de 1.074 participantes no Rio de Janeiro e 2.145 em São Paulo que reportaram ao menos um evento traumático durante a vida. O primeiro artigo investigou a validade estrutural da versão brasileira do PDEQ. Análises de componentes principais indicaram a solução unidimensional corroborada por análises fatoriais confirmatórias (AFC) e de tipo exploratórias realizadas no Mplus. A adequação de ajuste dos modelos foi aceita para valores de CFI, TLI maiores que 0,95 e de RMSEA abaixo de 0,06. Os índices de modificação indicaram uma alta correlação residual entre os itens 9 ('dificuldade para entender o que estava acontecendo') e o item 10 ('desorientação') que foi corroborada nas duas amostras por AFC e sugere redundância de conteúdo. Análises de escalabilidade utilizando H de Loevinger e a hipóstese de dupla monotonicidade indicaram boas propriedades escalares. A versão reduzida com exclusão do item 9 foi proposta para utilização em estudos epidemiológicos. O segundo artigo reportou o processo de desenvolvimento de um instrumento integrado para avaliar RP. A etapa qualitativa avaliou a validade de conteúdo de 36 itens, sendo 30 provenientes das principais escalas utilizadas para mensurar as três principais RP e mais 6 itens elaborados por especialistas. O conjunto de 34 itens resultantes do processo qualitativo teve sua estrutura configural e métrica avaliadas a partir de AFC e de tipo exploratória para as duas amostras no Mplus. Modelos com CFI e TLI acima de 0,95 e de RMSEA menores que 0,06 foram considerados com ajuste satisfatório. A versão proposta do PTRQ conta com 29 itens distribuídos nas três dimensões (DP, ITP e RFP) mostrou boa estrutura fatorial e métrica, sendo recomendado para uso em estudos epidemiológicos. Espera-se que os resultados desta tese contribuam para o refinamento do processo de mensuração das RP, necessário para se avançar o conhecimento sobre o seu papel no desenvolvimento do TEPT, assim como nas propostas de intervenção precoce em indivíduos sob maior risco de desenvolvimento desse transtorno mental


The role of reactions occurring in the course of traumatic experiences has been of interest in studies regarding the etiology and prognosis of the posttraumatic stress disorder (PTSD). This thesis evaluated the dimensional structure of the most used instrument for measuring peritraumatic dissociation (PD) - the Peritraumatic Dissociative Experience Questionnaire (PDEQ). Additionally, we developed and evaluated the psychometric properties of the instrument denominated Peritraumatic Reaction Questionnaire (PTRQ), proposed for evaluating the three main peritraumatic reactions (PR) in the context of PTSD: dissociation (PD), tonic immobility (TIP) and physical panic reaction (PPR). Data were obtained from a cross-sectional study developed between June 2007 and July 2008, including a representative sample of people aged 15 or more from the two largest Brazilian cities. A sample of 3,229 participants reported at least one traumatic event during their lifetime, 1,074 in Rio de Janeiro and 2,145 in São Paulo. The first article investigated the structural validity of the Brazilian version of the PDEQ. Principal component analyzes indicated the one-dimensional solution corroborated by confirmatory and exploratory factor analysis (CFA) performed in Mplus. The models were fit if CFI, TLI values greater than 0.95 and RMSEA values below 0.06. Modification indices indicated a high residual correlation between item 9 ('difficulty understanding what was happening') and item 10 ('disorientation') which was corroborated in both samples by AFC and suggests content redundancy. Scalability analyzes using Loevinger H and double monotonicity hypothesis indicated good scalar properties. The shortened version excluding item 9 has been proposed for use in epidemiological studies. The second article reported on the process of developing an integrated instrument to assess PR. The qualitative stage evaluated the content validity of 36 items, 30 of them from the main scales used to measure the three main PR and 6 more items prepared by experts. The set of 34 items resulting from the qualitative process had their configuration and metric structure evaluated from CFA and exploratory type for both samples in Mplus. Models with CFI and TLI above 0.95 and RMSEA less than 0.06 were considered with satisfactory fit. The proposed version of the PTRQ has 29 items distributed in the three dimensions (PD, ITP and RFP) presented good factorial and metric structure, and is recommended for use in epidemiological studies. We expect that the findings from this thesis may contribute to the refinement of PR measurement necessary to advance the knowledge about its role in PTSD development, as well as proposals for early intervention in individuals at higher risk of developing this mental disorder


Subject(s)
Humans , Psychometrics , Factor Analysis, Statistical , Panic Disorder , Immobility Response, Tonic , Dissociative Disorders , Psychological Trauma
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