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1.
Rev. Hosp. Ital. B. Aires (2004) ; 41(1): 26-30, mar. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1178336

ABSTRACT

El pioderma gangrenoso ampollar es una variedad infrecuente de pioderma gangrenoso, que se asocia en el 50-70% de los casos con trastornos oncohematológicos. Se comunica el caso de una paciente de 59 años, que consultó por fiebre y ampollas purpúricas de rápida progresión, con compromiso cutáneo mucoso. Con sospecha de una enfermedad neutrofílica, ampollar, o infección por gérmenes oportunistas, se realizó biopsia de piel para estudio histopatológico, inmunofluorescencia directa y cultivo. Los cultivos y la inmunofluorescencia directa fueron negativos, y la anatomía patológica reveló un denso infiltrado inflamatorio con predominio neutrofílico en dermis. Ante el diagnóstico de pioderma gangrenoso ampollar, se realizó una punción-aspiración de médula ósea cuyo resultado fue compatible con leucemia mieloide aguda. Se instauró tratamiento con corticosteroides sistémicos, a pesar de lo cual la paciente evolucionó desfavorablemente y falleció a los 15 días de su ingreso hospitalario. Este caso ilustra la asociación de esta enfermedad cutánea con trastornos oncohematológicos y el mal pronóstico que esto implica a corto plazo. (AU)


Bullous pyoderma gangrenosum is an infrequent type of pyoderma gangrenosum, associated with onco hematological diseases in 50-70% of cases. We present the case of a 59-year-old patient with fever and mucocutaneous hemorrhagic bullous of rapid progression. A biopsy for histopathology, direct immunofluorescence (DIF) and skin culture was made, considering the possibility of neutrophilic dermatoses, bullous dermatosis or an opportunistic infection. The results of both the culture and the DIF were negative. The histopathological examination of the specimen revealed a dense dermal polymorphic infiltrate composed primarily of neutrophils. Considering bullous pyoderma gangrenosum as a potential diagnosis, a bone-marrow biopsy was performed. This study revealed an acute myeloid leukemia. Although systemic corticosteroid therapy was begun, the patient presented an unfavorable evolution that led to her death 15 days after her admission at the hospital. This case shows the association between bullous pyoderma gangrenosum and onco hematological diseases. In addition, it highlights the poor prognosis related to these diseases in the short term. (AU)


Subject(s)
Humans , Female , Middle Aged , Leukemia, Myeloid, Acute/pathology , Pyoderma Gangrenosum/diagnosis , Paraneoplastic Syndromes/pathology , Respiration, Artificial , Azacitidine/therapeutic use , Myelodysplastic Syndromes/pathology , Acyclovir/administration & dosage , Methylprednisolone/administration & dosage , Vancomycin/administration & dosage , Cardiotonic Agents/therapeutic use , Ceftazidime/administration & dosage , Amphotericin B/administration & dosage , Imipenem/administration & dosage , Sweet Syndrome/etiology , Pyoderma Gangrenosum/etiology , Pyoderma Gangrenosum/pathology , Pyoderma Gangrenosum/drug therapy , Adrenal Cortex Hormones/therapeutic use , Meropenem/administration & dosage
2.
Rev. colomb. reumatol ; 27(3): 224-229, jul.-set. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1251663

ABSTRACT

RESUMEN Los síndromes paraneoplásicos neurológicos se presentan en menos del 1% de los tumores sólidos y son infrecuentes en linfomas. Se asocian a tumores con alta actividad biológica y condicionan deterioro funcional y discapacidad. La dermatomiositis se asocia a cáncer, por tanto obliga al estudio de neoplasias ocultas; su diagnóstico como síndrome paraneoplásico se establece con criterios específicos. El pronóstico funcional depende del diagnóstico oportuno, control del cáncer y de la regulación de la respuesta inmunológica. Se presenta el caso de una mujer de 65 años con dermatomiositis en el curso de un linfoma B marginal variante convencional de primario cutáneo.


ABSTRACT Neurological paraneoplastic syndromes occur in less than 1% of solid tumours and are uncommon in lymphomas. They are related to tumours with high biological activity and cause functional impairment and disability. Dermatomyositis is associated with cancer, and requires the study of hidden neoplasms. Its diagnosis as a paraneoplastic syndrome is established with specific criteria. Functional prognosis depends on early diagnosis, cancer control, and regulation of the immune response. The case is presented of a 65 year-old woman with dermatomyositis during the course of a conventional variant of a primary cutaneous B marginal lymphoma.


Subject(s)
Humans , Female , Middle Aged , Dermatomyositis , Lymphoma , Paraneoplastic Syndromes , Diagnosis , Neoplasms
3.
Rev. colomb. reumatol ; 27(2): 130-134, ene.-jun. 2020. tab
Article in Spanish | LILACS | ID: biblio-1251647

ABSTRACT

RESUMEN El síndrome de persona rígida afecta el sistema nervioso central. Los signos clínicos relevantes son la rigidez, los espasmos musculares y sensibilidad incrementada a los estímulos externos, que inducen las contracciones musculares. Las mujeres son afectadas de 2 a 3 veces más con relación a los hombres. Hay marcadores de tipo clínico y electrofisiológico característicos. La etiología se asocia con la mediación por anticuerpos y puede ser la expresión de un síndrome paraneoplásico. El tratamiento farmacológico se realiza con medicamentos relajantes musculares y medicamentos con mecanismo inmunomodulador o inmunosupresor. Adicionalmente, se requiere un plan complementario de rehabilitación. El propósito del grupo es hacer una descripción del caso clínico, que consideramos es relevante por su baja frecuencia de presentación y realizar una actualización sobre el tema.


A B S T R A C T Stiff person syndrome affects the central nervous system. Relevant clinical signs are stiffness, muscle spasms, increased sensitivity with external stimuli that increase muscle contractions. Women are affected twice to three times more, in comparation with the men. There are characteristic clinical and electrophysiological type markers. The etiology is associated with mediation by antibodies and may be the expression of a paraneoplastic syndrome. Pharmacological treatment is focused on muscle relaxant-type medications, drugs with immunomodulatory or immunosuppressive mechanism. In adition, complementary rehabilitation treatment is required. The purpose of the group is to make the description of the clinical case that is relevant due to the low frequency of presentation and to carry out an update of the topic.


Subject(s)
Humans , Female , Therapeutics , Central Nervous System , Stiff-Person Syndrome , Paraneoplastic Syndromes , Signs and Symptoms , Women , Sensitivity and Specificity , Muscle Contraction
4.
An. bras. dermatol ; 94(4): 388-398, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1038294

ABSTRACT

Abstract: Paraneoplastic pemphigus is a rare and severe autoimmune blistering disease characterized by mucocutaneous lesions associated with benign and malignant neoplasms. Diagnostic criteria include the presence of chronic mucositis and polymorphic cutaneous lesions with occult or confirmed neoplasia; histopathological analysis exhibiting intraepidermal acantholysis, necrotic keratinocytes, and vacuolar interface dermatitis; direct immunofluorescence with intercellular deposits (IgG and C3) and at the basement membrane zone (IgG); indirect immunofluorescence with intercellular deposition of IgG (substrates: monkey esophagus and simple, columnar, and transitional epithelium); and, autoreactivity to desmogleins 1 and 3, desmocollins 1, 2, and 3, desmoplakins I and II, envoplakin, periplakin, epiplakin, plectin, BP230, and α-2-macroglobulin-like protein 1. Neoplasias frequently related to paraneoplastic pemphigus include chronic lymphocytic leukemia, non-Hodgkin lymphoma, carcinomas, Castleman disease, thymoma, and others. Currently, there is no standardized treatment for paraneoplastic pemphigus. Systemic corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine, rituximab, cyclophosphamide, plasmapheresis, and intravenous immunoglobulin have been used, with variable outcomes. Reported survival rates in 1, 2, and 5 years are 49%, 41%, and 38%, respectively.


Subject(s)
Humans , Paraneoplastic Syndromes/pathology , Paraneoplastic Syndromes/therapy , Pemphigus/immunology , Pemphigus/pathology , Pemphigus/therapy , Paraneoplastic Syndromes/immunology , Skin/pathology , Autoantibodies/immunology , Pemphigus/diagnosis , Erythema/diagnosis , Erythema/pathology , Mouth Diseases/diagnosis , Mouth Diseases/pathology
5.
Rev. Eugenio Espejo ; 13(1): 53-61, Ene-Jul. 2019.
Article in Spanish | LILACS | ID: biblio-1006782

ABSTRACT

Caso clínico: paciente masculino de 81 años de edad, con cuadro de 24 horas de evolución secundario a caída, caracterizado por somnolencia, desorientación en persona, tiempo y espacio, incontinencia urinaria y dificultad para la deambulación, motivo por el cual se le efectúa una tomografía simple de cráneo encontrándose hematomas subdurales bilaterales, presenta episodios de sangrado recurrente y leucocitosis sostenida , en frotis de sangre periférica se observó 28% de blastos por lo que se realiza una biopsia de medula ósea descubriéndose un cariotipo medular compatible con leucemia mieloide aguda, debido a sus características clínicas y a su mala evolución fue catalogado como paciente paliativo. Conclusiones: la leucemia mieloide aguda es una patología hematológica cuya evolución al no ser detectada genera un alto grado de mortalidad, sobre todo en el adulto mayor comórbido.


It was presented a clinical case of a male patient of 81 years of age, with a 24-hour of secondary evolution to a fall. It was characterized by drowsiness, disorientation in person, time and space, urinary incontinence and difficulty in walking, that was why a simple skull tomography was performed, in which bilateral subdural hematomas were found. The patient presented episodes of recurrent bleeding and sustained leukocytosis. Peripheral blood smear showed 28% of blasts, so a bone marrow biopsy was performed, revealing a medullary karyotype compatible with acute myeloid leukemia. The patient was classified as palliative due to its clinical characteristics and evolution. The hematological pathology above was potentially fatal. If this one was not detected early, it would generate an accelerated unfavorable evolution, especially in the elderly comorbid, as occurred in the case presented.


Subject(s)
Humans , Male , Aged, 80 and over , Hematologic Neoplasms , Hematologic Diseases , Hemic and Lymphatic Diseases , Paraneoplastic Syndromes , Neoplasms , Neoplastic Processes
6.
J. oral res. (Impresa) ; 8(3): 249-253, jul. 31, 2019. ilus
Article in English | LILACS | ID: biblio-1145343

ABSTRACT

Malignant-or-paraneoplastic acanthosis nigricans is a verrucous and hyperpigmented tumor affecting the mucosa and skin. In most cases malignant acanthosis nigricans is a distant manifestation of an intra-abdominal primary cancer. While the diagnosis of malignant acanthosis nigricans is challenging, some specific clinical and histopathological findings could lead to an accurate diagnosis. A rare clinical case of a 59-year-old female, who was referred to the maxillofacial surgery service due to a painful oral lesion in the palatine region, is presented. Upon examination, papillomatous lesions were observed on the hard palate, that were later diagnosed as intraoral malignant acanthosis nigricans secondary to gastric cancer. Both local and systemic evaluations are discussed, highlighting the relevance of a multidisciplinary approach consistent with the fact that these manifestations, although infrequent, should generate suspicion among clinicians and therefore motivation to perform a diligent and complete study since it can reveal the presence of a malignant pathology.


La acantosis nigricans maligna o paraneoplásica es un tumor verrugoso e hiperpigmentado que afecta la mucosa y la piel. En la mayoría de los casos, la acantosis nigricans maligna es una manifestación distante de un cáncer primario intraabdominal. Si bien el diagnóstico de acantosis nigricans maligna es desafiante, algunos hallazgos clínicos e histopatológicos específicos podrían conducir a un diagnóstico preciso. Se presenta un caso clínico raro de una mujer de 59 años, que fue derivada al servicio de cirugía maxilofacial debido a una lesión oral dolorosa en la región palatina. En el examen, se observaron lesiones papilomatosas en el paladar duro, que posteriormente se diagnosticaron como acantosis nigricans maligna intraoral secundaria a cáncer gástrico. Se discuten tanto las evaluaciones locales como las sistémicas, destacando la relevancia de un enfoque multidisciplinario consistente con el hecho de que estas manifestaciones, aunque poco frecuentes, deberían generar sospecha entre los clínicos y, por lo tanto, motivación para un estudio diligente y completo, ya que puede revelar la presencia de una patología maligna.


Subject(s)
Humans , Female , Middle Aged , Stomach Neoplasms/complications , Acanthosis Nigricans/therapy , Paraneoplastic Syndromes , Surgery, Oral , Palate, Hard/injuries , Acanthosis Nigricans/diagnosis
7.
Rev. bras. neurol ; 55(2): 36-40, abr.-jun. 2019. ilus
Article in English | LILACS | ID: biblio-1010062

ABSTRACT

Hermann Oppenheim (1858-1919) was a leading fgure of the modern German neurology. In spite of the antisemitic ofcial policy, besides his complex personality, he had achieved widespread recognition of his professional qualifcation that attracted neurologists from all around the world to his private clinic. However, he did not held prominent positions at University milieu, in spite of being the main assistant to Karl Westphal (1833­1890) at the Charité-Hospital, in Berlin. Oppenheim was the author of an encyclopedic book of neurology titled "Lehrbuch der Nervenkrankheiten für Ärzte und Studierende" ("Textbook of Nervous Diseases for Doctors and Students"), frst ed., 1894. He also published signifcant works on several disorders, including "traumatic neurosis" (1889) that was criticized by Jean-Martin Charcot (1825­1893), among others. He was clinically responsible for the frst successful removal of brain tumors, including pineal tumor. He coined the term "dystonia musculorum deformans", and he led to several other achievements such as amyotonia congenita ("Oppenheim's disease"), besides Oppenheim's reflex.


Hermann Oppenheim (1858-1919) foi uma fgura importante da moderna neurologia alemã. Apesar da política ofcial anti-semita, além de sua personalidade complexa, ele alcançou amplo reconhecimento de sua qualifcação profssional que atraiu neurologistas de todo o mundo para sua clínica particular. No entanto, ele não ocupou posições de destaque no meio universitário, apesar de ser o principal assistente de Karl Westphal (1833-1890) no Charité-Hospital, em Berlim. Oppenheim foi o autor de um livro enciclopédico de neurologia intitulado "Lehrbuch der Nervenkrankheiten für Ärzte und Studierende" ("Livro Didático de Doenças Nervosas para Médicos e Alunos"), editado em 1894. Ele também publicou trabalhos signifcativos sobre vários distúrbios, incluindo "neurose traumática" ( 1889) que foi criticado por Jean-Martin Charcot (1825­1893), entre outros. Ele foi clinicamente responsável pela primeira remoção bem sucedida de tumores cerebrais, incluindo o tumor pineal. Ele cunhou o termo "distonia musculorumdeformans" e levou a outras várias conquistas como a amiotonia congênita ("doença de Oppenheim"), além do reflexo de Oppenheim.


Subject(s)
Humans , History, 19th Century , Paraneoplastic Syndromes/history , Combat Disorders , Nervous System Diseases/history , Neurology/history , Neuromuscular Diseases/history , Stress Disorders, Post-Traumatic , Neuropsychiatry , Germany
8.
Article in Korean | WPRIM | ID: wpr-759764

ABSTRACT

Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by typical cutaneous manifestation and inflammation of the skeletal muscles. However, this progressive symmetric proximal muscle weakness may be minimal or absent in clinically amyopathic DM (CADM). Importantly, DM has been associated with malignancy, which is related to poor prognosis. Therefore, every newly diagnosed patient with DM should undergo thorough screening investigations for hidden internal malignancy. We report a case of CADM, with severe intractable itching, which was finally diagnosed as paraneoplastic dermatomyositis associated with gastric cancer in a 77-year-old woman. The patient had typical cutaneous features of DM and mild elevation of muscle enzymes without muscle weakness.


Subject(s)
Aged , Dermatomyositis , Female , Humans , Inflammation , Mass Screening , Muscle Weakness , Muscle, Skeletal , Myositis , Paraneoplastic Syndromes , Prognosis , Pruritus , Stomach Neoplasms
9.
Article in English | WPRIM | ID: wpr-764565

ABSTRACT

OBJECTIVE: To analyze the clinical characteristics, prognosis and parallel clinical course of ovarian cancer (OC) and dermatomyositis (DM). METHODS: The medical records of 23 consecutive patients who were diagnosed with OC and DM and were treated at Peking Union Medical College Hospital (PUMCH) between 2002 and 2017 were reviewed. Propensity score matching method was used to match control group (OC patients without DM) at a ratio of 1:5. The correlation between OC and DM was measured using the Pearson correlation scatter plot and Pearson's r. Kaplan-Meier survival analysis and Cox proportional hazard regression analysis were performed to evaluate the prognostic factors. RESULTS: After matching, 23 patients who have the concurrence of OC and DM (DM group) and 115 patients diagnosed with OC alone (No DM group) were included. The 5-year overall survival rates (71.6% vs. 51.8%, p=0.020) and 5-year progression-free survival (30.5% vs. 0%, p=0.018) were poorer in DM group. Correlation between serum cancer antigen 125 (CA 125) and creatine kinase (CK) level was observed in 12 patients. The time between OC and DM diagnosis is significant through univariable analysis (p=0.021) but not in multivariable analysis in patients who have the concurrence of OC and DM. CONCLUSION: The concurrence of OC and DM as a paraneoplastic syndrome is rare and has a poor prognosis. The risk for patients diagnosed with DM is highest within 3 years before or after OC diagnosis. A correlation and a parallel clinical course exist between these 2 diseases.


Subject(s)
Beijing , Creatine Kinase , Dermatomyositis , Diagnosis , Disease-Free Survival , Humans , Medical Records , Methods , Ovarian Neoplasms , Paraneoplastic Syndromes , Prognosis , Propensity Score , Survival Rate , Treatment Outcome
10.
Article in Korean | WPRIM | ID: wpr-766766

ABSTRACT

Anti-Ma2-associated encephalitis is one of the paraneoplastic limbic and brainstem encephalitis characterized by decreased consciousness, parkinsonism and the limitation of vertical eye movement. It is usually associated with non-small cell lung cancer in male and female or germ cell tumor in male. Herein, we report a case of atypical anti-Ma2-associated encephalitis which presented with axonal sensorimotor polyneuropathy.


Subject(s)
Autoantibodies , Axons , Brain Stem , Carcinoma, Non-Small-Cell Lung , Consciousness , Encephalitis , Eye Movements , Female , Humans , Limbic Encephalitis , Male , Neoplasms, Germ Cell and Embryonal , Paraneoplastic Syndromes , Parkinsonian Disorders , Polyneuropathies
13.
Article in English | WPRIM | ID: wpr-762438

ABSTRACT

POEMS syndrome is a rare paraneoplastic syndrome, which includes polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes due to plasma cell (PC) neoplasm. Diagnosis of this disease is challenging because of its rarity and complex clinical manifestations. We attempted to identify the key clinical features and characteristic bone marrow (BM) findings of POEMS syndrome, by reviewing the medical records and BM analyses of 24 Korean patients. Frequent clinical manifestations included polyneuropathy (100%), monoclonal gammopathy (100%), organomegaly (92%), extravascular volume overload (79%), and endocrinopathy (63%). The BM analyses revealed mild PC hyperplasia (median PCs: 5.5%) and frequent megakaryocytic hyperplasia (88%), megakaryocyte clusters (88%), and hyperlobation (100%). Flow cytometry of BM aspirates using CD138/CD38/CD45/CD19/CD56 showed normal (67%, 4/6) or neoplastic PC immunophenotypes (33%, 2/6). A diagnosis of POEMS syndrome must be considered when a patient suspected of having PC dyscrasia shows the above clinical presentation and BM findings.


Subject(s)
Bone Marrow , Diagnosis , Flow Cytometry , Humans , Hyperplasia , Medical Records , Megakaryocytes , Paraneoplastic Syndromes , Paraproteinemias , Plasma Cells , POEMS Syndrome , Polyneuropathies , Skin
14.
Annals of Dermatology ; : 678-680, 2019.
Article in English | WPRIM | ID: wpr-762386

ABSTRACT

Orofacial granulomatosis is a rare granulomatous inflammatory disease, characterized by recurrent orofacial swelling. Infectious, genetic, and immunologic etiologies are suggested, but not fully understood. Herein, we report a case of synchronous orofacial granulomatosis with brain cavernous hemangioma in a 44-year-old female patient, which may be considered paraneoplastic syndrome.


Subject(s)
Adult , Brain , Female , Granulomatosis, Orofacial , Hemangioma, Cavernous , Hemangioma, Cavernous, Central Nervous System , Humans , Paraneoplastic Syndromes
15.
Clinical Pain ; (2): 88-91, 2019.
Article in English | WPRIM | ID: wpr-811489

ABSTRACT

Unexplained pain and weakness, i.e., without obvious predisposing factors, are often encountered by physiatrists and efforts should be made to determine the cause. A 63-year-old male presented with radiating pain in his right arm and mild weakness of the right hand. An electrodiagnostic examination revealed distal symmetric sensory polyneuropathy in the upper and lower extremities, and denervation potentials in the forearm muscles, which were inconsistent with the cervical spine MRI images and symptoms. A predisposing undiscovered disease was revealed, i.e., squamous cell carcinoma in the lung; brain metastasis affecting the left primary motor cortex was also detected. Therefore, we concluded that the pain and weakness were related to paraneoplastic syndrome and brain metastases of the hand knob. The observed denervation potentials were characterized as trans-synaptic changes in the brain metastasis. This case highlights the importance of unexplainable focal pain and weakness in the increasing prevalence of cancer.


Subject(s)
Arm , Brain , Carcinoma, Non-Small-Cell Lung , Carcinoma, Squamous Cell , Causality , Denervation , Forearm , Hand , Humans , Lower Extremity , Lung , Lung Neoplasms , Magnetic Resonance Imaging , Male , Middle Aged , Motor Cortex , Muscles , Neoplasm Metastasis , Paraneoplastic Syndromes , Polyneuropathies , Prevalence , Spine
16.
Rev. méd. panacea ; 7(3): 112-115, sept.-dic. 2018. ilus, tab
Article in Spanish | LILACS | ID: biblio-1021212

ABSTRACT

Se presenta el caso de paciente mujer de 79 años que presenta fiebre, placas eritemato-violáceas y ampollas de contenido seroso, dolorosas en el antebrazo y dorso de la mano izquierda.Los hemogramas seriados revelaron la presencia de anemia, leucocitosis marcada con neutrofilia, trombocitopenia y linfopenia. Se realiza lámina periférica donde se observa blastos (79%) y cuerpos de Auer. La biopsia de la lesión cutánea señala un infiltrado denso perivascular de neutrófilos maduros en la dermis superficial sin vasculitis asociada. Se diagnosticó Síndrome de Sweet asociado a Leucemia mieloide aguda, iniciando terapia de acuerdo a protocolo.El síndrome de Sweet es una afección cutánea poco frecuente de causa desconocida que se caracteriza por aparición brusca de fiebre, afectación del estado general y lesiones tipo placas o nódulos eritematosos muy dolorosos, con o sin pseudovesículas, de predominio en el hemicuerpo superior. Además, es frecuente leucocitosis, neutrofilia y PCR elevado. (AU)


We present the case of a 79-year-old female patient with fever, erythematous-violaceous plaques and blisters of serous content, painful on the forearm and back of the left hand.Serial blood tests revealed the presence of anemia, leukocytosis marked with neutrophilia, thrombocytopenia and lymphopenia. Peripheral lamina is where blastos (79%) and Auer bodies are observed. The biopsy of the skin lesion indicates a dense perivascular infiltrate of mature neutrophils in the superficial dermis without associated vasculitis. Sweet syndrome associated with acute myeloid leukemia was diagnosed, initiating therapy according to protocol.Sweet syndrome is a rare skin condition of unknown cause that is characterized by sudden onset of fever, general condition impairment and very painful plaque or erythematous nodule lesions, with or without pseudovesicles, predominantly in the upper hemibody. Also, leukocytosis, neutrophilia and elevated CRP are frequent. (AU)


Subject(s)
Humans , Female , Aged , Leukemia, Myeloid, Acute , Sweet Syndrome , Paraneoplastic Syndromes
18.
An. bras. dermatol ; 93(4): 576-578, July-Aug. 2018. graf
Article in English | LILACS | ID: biblio-949934

ABSTRACT

Abstract: Sweet's syndrome is a rare dermatosis with little-known pathogenesis, associated with some clinical conditions such as infections, autoimmune diseases, inflammatory bowel diseases, vaccination, medications and neoplasms. Hematologic malignancies are the diseases most related to paraneoplastic Sweet's syndrome, but this clinical entity can also be found occasionally in some solid tumors, including genitourinary tract tumors. We report a rare case of paraneoplastic Sweet's syndrome associated with the diagnosis of cervical cancer.


Subject(s)
Humans , Female , Middle Aged , Paraneoplastic Syndromes/pathology , Uterine Cervical Neoplasms/pathology , Sweet Syndrome/pathology , Paraneoplastic Syndromes/complications , Uterine Cervical Neoplasms/complications , Sweet Syndrome/complications , Diagnosis, Differential , Neoplasm Recurrence, Local
19.
Med. UIS ; 31(2): 41-47, mayo-ago. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-1002509

ABSTRACT

Resumen El cáncer de mama es un importante problema de salud pública. Aunque es infrecuente, uno de los síndromes paraneoplásicos del cáncer de seno es la dermatomiositis. Es necesario que el clínico tenga conocimientos sobre cómo diagnosticarla y tratarla adecuadamente. El objetivo de este artículo es realizar una revisión de la literatura sobre la clínica, complicaciones y tratamiento de la dermatomiositis en el cáncer de mama. Se realizó una búsqueda en diferentes bases de datos electrónicas, incluyendo un total de 34 artículos, abarcando ensayos clínicos aleatorizados, metaanálisis, artículos originales descriptivos y analíticos y reportes de caso. La dermatomiositis puede presentarse antes, durante, o después del cáncer de mama. Son frecuentes las complicaciones pulmonares, que pueden llegar a ser letales. La dermatomiositis aumenta las complicaciones por radioterapia y la mortalidad en los pacientes con cáncer de seno. El tratamiento farmacológico consiste en la aplicación de glucocorticoides a dosis según necesidad del paciente. MÉD.UIS. 2018;31(2):41-7.


Abstract Breast cancer is an important public health problem. Dermatomyositis is an infrequent paraneoplastic syndrome of breast cancer. It is necessary that the clinician has knowledge on how to diagnose and treat it properly. The aim of this article is to review the literature on the clinical, complications and treatment of dermatomyositis in breast cancer. A search was made in electronic databases, including a total of 34 articles, covering randomized clinical trials, meta-analyzes, original descriptive and analytical articles and case reports. Dermatomyositis can occur before, during, or after breast cancer. Pulmonary complications are frequent, and they can be lethal. Dermatomyositis increases the complications of radiotherapy and mortality in patients with breast cancer. The pharmacological treatment consists of glucocorticoid application at doses according to the patient's need. MÉD.UIS. 2018;31(2):41-7.


Subject(s)
Humans , Female , Dermatomyositis , Paraneoplastic Syndromes , Breast Neoplasms
20.
Rev. méd. Chile ; 146(4): 534-537, abr. 2018. graf
Article in Spanish | LILACS | ID: biblio-961426

ABSTRACT

An assortment of clinical and laboratory abnormalities may occur as paraneoplastic syndromes in lymphomas. Rheumatological and dermatological manifestations such as paraneoplastic arthritis and pyoderma gangrenosum must be underscored. We report a 28 years old woman who developed pyoderma gangrenosum and two years later presented with arthritis of knees and ankles associated with panniculitis interpreted as erythema induratum that was pathologically confirmed. She developed a reactivation of pyoderma gangrenosum, that was refractory to treatment. Complementary studies showed a pulmonary nodule and a right paravertebral mass with involvement of the psoas muscle. Biopsies of both masses and a new pathological skin study demonstrated a large B-cell non-Hodgkin's lymphoma.


Subject(s)
Humans , Female , Adult , Paraneoplastic Syndromes/complications , Arthritis/etiology , Lymphoma, Non-Hodgkin/complications , Panniculitis/etiology , Pyoderma Gangrenosum/etiology , Paraneoplastic Syndromes/diagnosis , Paraneoplastic Syndromes/drug therapy , Arthritis/diagnosis , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/drug therapy , Panniculitis/diagnosis , Pyoderma Gangrenosum/drug therapy
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