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1.
Rev. bras. ciênc. vet ; 28(4): 190-197, out./dez. 2021. il.
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1363199

ABSTRACT

As lesões decorrentes de atropelamento são as principais causas de fraturas e luxações vertebrais, ocasionando graus variáveis de injúrias vertebrais e medulares. O presente trabalho tem como objetivo relatar a ocorrência de lesão traumática em coluna vertebral de cão sem raça definida, com quatro anos de idade, resultando em luxação T11-12, com exposição de T11 e secção medular, estando o paciente paraplégico, com sinais de lesão em neurônio motor superior e ausência de nocicepção profunda em membros pélvicos. O tratamento de escolha foi a vertebrectomia de T11, associada ao alinhamento de T10-12 com introdução de pinos e fixação com polimetilmetacrilato (PMMA) associado à ceftriaxona. Em decorrência de lesão na pleura parietal no trans-cirúrgico, optou-se pela toracostomia para introdução de tubo torácico, o qual permaneceu no paciente por quatro dias. No pós-operatório, o paciente apresentou recuperação satisfatória, sendo recomendado aos tutores a confecção de cadeira de rodas a fim de facilitar sua locomoção. A técnica mostrou-se satisfatória para minimizar as infecções passíveis de ocorrência em fraturas expostas, bem como melhorar a qualidade de vida do paciente, evitando-se dores crônicas.


Injuries resulting from being run over are the leading causes of vertebral fractures and dislocations, causing varying vertebral and spinal injuries. The present study aims to report the occurrence of traumatic injury to the spine of a mixed breed dog, aged four years, resulting in a T11-12 dislocation, with T11 exposure and spinal section, with the patient showing paraplegia, signs of an upper motor neuron lesion and absence of deep nociception in pelvic limbs. The treatment of choice was T11 vertebrectomy, associated with the alignment of T10-12 with the introduction of pins and fixation with polymethylmethacrylate (PMMA) associated with ceftriaxone. Due to a lesion in the parietal pleura during the surgery, thoracostomy was chosen to introduce a chest tube, which remained in the patient for four days. In the postoperative period, the patient presented a satisfactory recovery, and it was recommended that tutors make a wheelchair to facilitate their mobility. The technique proved to be satisfactory for minimizing infections that could occur in open fractures and improving the patient's quality of life, avoiding chronic pain.


Subject(s)
Animals , Spinal Cord Injuries/veterinary , Surgery, Veterinary , Spinal Fractures/veterinary , Paraplegia/veterinary , Thoracostomy/veterinary , Fracture Dislocation/veterinary
2.
Rev. cuba. invest. bioméd ; 40(2): e941, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347453

ABSTRACT

Introducción: La paraplejia es una condición de salud ocasionada por lesiones lumbares que conlleva a las personas a permanecer la mayor parte de su tiempo postradas, ocasionando problemas de respiración, variaciones en la presión arterial y la aparición de úlceras en sus partes de apoyo. Objetivo: Desarrollar un sistema mecatrónico que permita la bipedestación de personas con condición de paraplejias. Métodos: La investigación se realizó en dos etapas, el desarrollo de un sistema mecatrónico y una fase de validación de uso por usuarios con discapacidad motora. Resultados: Las pruebas de funcionamiento muestran que los atractivos más importantes del equipo son su capacidad de ajuste (permitiendo su uso a personas con diferencias antropométricas) y su operatividad. Conclusiones: El bipedestador diseñado cumplió las condiciones requeridas para realizar la transición a condición bípeda, con las medidas de seguridad en las partes críticas que garantizan la estabilidad del usuario. Además, el bipedestador posee mecanismos sencillos de operar, acorde con sus capacidades. La validación del implemento demostró que es de un tamaño adecuado y de fácil utilización, además al ser reajustable para su uso independientemente de la condición morfométrica.(AU)


Introduction: Paraplegia is an impairment in motor functioning of the lower extremities. Caused by lumbar lesions, it deprives its sufferers from their ability to move about, which results in breathing problems, arterial pressure variations and the appearance of ulcers in pressure areas. Objective: Develop a mechatronic system permitting the bipedal locomotion of paraplegics. Methods: The study was structured into two stages: development of a mechatronic system and validation of its use by people with motor disability. Results: Function tests show that the most attractive features of the device are its adjustability (allowing use by anthropometrically different people) and its operability. Conclusions: The standing frame designed met the conditions required for the transition to bipedal condition, with safety measures in its critical parts which ensure user stability. Additionally, its mechanisms are easy to operate, in keeping with its capabilities. Validation of the device showed that its size is appropriate, its operation simple, and it may be readjusted for use in different morphometric conditions(AU)


Subject(s)
Humans , Male , Female , Paraplegia , Security Measures , Equipment and Supplies , Standing Position
3.
Rev. bras. ortop ; 55(1): 70-74, Jan.-Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1092675

ABSTRACT

Abstract Objective The aim of the present study is to evaluate the artery of Adamkiewicz by multidetector computed tomography angiography (MCTA) in a Brazilian population. Methods Two independent observers evaluated 86 coronary MCTA examinations. The variables studied included the identification of the artery of Adamkiewicz at its origin level, and its entry side in the spine. Results The artery of Adamkiewicz was detected in 71 (82.5%) examinations. The origin level was identified between the 9th and 11th thoracic vertebrae (T9 and T11) in 56 (79.2%) patients. In 65 (91.5%) patients, the artery was on the left side. The identification of the artery of Adamkiewicz using MCTA showed high reproducibility. Conclusions Our results were consistent with the literature regarding the identification of the artery of Adamkiewicz using MCTA, suggesting that this technique should be considered as an option to recognize this structure. In addition, we found that the distribution of the artery of Adamkiewicz in the Brazilian population is similar to that of other populations, that is, its most common origin is at the left side, between the 8th and 12th thoracic vertebrae (T8-T12).


Resumo Objetivo Avaliar a artéria de Adamkiewicz por angiotomografia computadorizada por multidetectores (ATCM) em uma população brasileira. Métodos Dois observadores independentes avaliaram 86 exames de ACTM. As variáveis estudadas incluíram a identificação da artéria de Adamkiewicz no nível de origem e o lado de entrada da artéria na coluna vertebral. Resultados A artéria de Adamkiewicz foi identificada em 71 (82,5%) exames. O nível de origem foi identificado entre a 9a e a 11a vértebras torácicas (T9 e T11) em 56 (79,2%) pacientes. Em 65 (91,5%) pacientes, a artéria foi identificada no lado esquerdo. A identificação da artéria de Adamkiewicz usando ACTM mostrou elevada reprodutibilidade. Conclusões Obtivemos resultados consistentes com os da literatura prévia quanto à identificação da artéria de Adamkiewicz utilizando angiotomografia computadorizada por multidetectores. Nossos resultados sugerem que a ATCM pode ser considerada como uma opção para identificar a artéria de Adamkiewicz. Além disso, encontramos uma distribuição da artéria de Adamkiewicz na população brasileira semelhante à de outras populações, com a artéria de Adamkiewicz originando-se mais comumente no lado esquerdo, entre a 8a e a 12a vértebras torácicas (T8-T12).


Subject(s)
Humans , Male , Female , Paraplegia , Arteries/pathology , Spinal Cord , Angiography/methods , Multidetector Computed Tomography
4.
Fisioter. Mov. (Online) ; 33: e003336, 2020. tab, graf
Article in English | LILACS | ID: biblio-1133908

ABSTRACT

Abstract Introduction: Due to motivation and immediate feedback during activities, exergame-based physical therapy may improve trunk balance and functionality in individuals with spinal cord injury (SCI). Objective: evaluate the effects of exergames on the trunk control of paraplegics with spinal cord injury or meningomyelocele. Method: case series involving four paraplegic patients, with SCI or meningomyelocele. Participants underwent a rehabilitation protocol using the exergame Nintendo Wii®, attending one weekly session for 4 weeks. Patients were encouraged to perform trunk movements in the sitting position using the Swordplay and Canoeing games. Data were collected before and after the intervention by applying the functional reach test adapted for trunk control evaluation, and transfer time and propulsion tests for functional assessment. Results: The intervention increased trunk control in 75% of the patients, with improvement varying between 6.4 and 25%. In the propulsion test, the intervention led to a decrease in half of the patients. For the cadence variable, in the same test, there was a reduction in the number of propulsions in 75% of the cases. In the transfer test, the intervention led to reduced chair-to-bed transfer time in all patients. Conclusion: Rehabilitation of paraplegics with the use of exergames can be considered viable, innovative and effective. However, future research with greater methodological rigor should be conducted in order to analyze the clinical applicability of this approach.


Resumo Introdução: Em virtude da motivação e do feedback imediato durante as atividades, os exergames durante a Fisioterapia podem favorecer o equilíbrio de tronco e a funcionalidade em lesados medulares. Objetivo: Avaliar os efeitos dos exergames no controle de tronco de paraplégicos. Método: Série de casos com quatro pacientes paraplégicos, portadores de lesão medular ou mielomeningocele. Os participantes foram submetidos a um protocolo de reabilitação com o uso do exergame Nintendo Wii®, com frequência de uma sessão semanal durante 4 semanas. O paciente foi estimulado a realizar movimentos de tronco na posição sentada através dos jogos esgrima e canoagem. Os instrumentos utilizados para a coleta de dados antes e depois da intervenção foram o Teste de Alcance Funcional adaptado para avaliação do controle de tronco, e o Tempo de Transferência e o Teste de Propulsão para a avaliação funcional. Resultados: A intervenção gerou um aumento absoluto do controle de tronco em 75% dos pacientes, com a melhora variando entre 6,4 e 25%. No Teste de Propulsão, a intervenção levou à redução absoluta do tempo em metade dos pacientes. Para a variável cadência, no mesmo teste, houve redução do número de propulsões em 75% dos casos. No Teste de Transferências, a intervenção gerou redução do tempo entre a cadeira e a cama em todos os pacientes. Conclusão: A reabilitação de paraplégicos com o uso de exergames pode ser considerada viável, inovadora e efetiva. No entanto, pesquisas futuras com maior rigor metodológico devem ser realizadas com vistas à aplicabilidade clínica desta abordagem.


Subject(s)
Humans , Male , Female , Paraplegia , Spinal Cord Injuries , Video Games , Postural Balance , Meningomyelocele , Physical Therapy Specialty , Movement
5.
Article in Chinese | WPRIM | ID: wpr-879481

ABSTRACT

OBJECTIVE@#To explore the genetic basis for a pedigree affected with hereditary spastic paraplegia type 4 (HSP4).@*METHODS@#Peripheral venous blood samples were taken from members of the four-generation pedigree and 50 healthy controls for the extraction of genomic DNA. Genes associated with peripheral neuropathy and hereditary spastic paraplegia were captured and subjected to targeted capture and next-generation sequencing. The results were confirmed by Sanger sequencing.@*RESULTS@#DNA sequencing suggested that the proband has carried a heterozygous c.1196C>G variant in exon 9 of the SPAST gene, which can cause substitution of serine by threonine at position 399 (p.Ser399Trp) and lead to change in the protein function. The same variant was also detected in other patients from the pedigree but not among unaffected individuals or the 50 healthy controls. Based on the ACMG 2015 guidelines, the variant was predicted to be possibly pathogenic.@*CONCLUSION@#The c.1196C>G variant of the SPAST gene probably underlay the HSP4 in this pedigree.


Subject(s)
Base Sequence , Humans , Mutation , Paraplegia/genetics , Pedigree , Sequence Analysis, DNA , Spastic Paraplegia, Hereditary/genetics , Spastin/genetics
6.
Rev. cub. inf. cienc. salud ; 30(3): e1382, jul.-set. 2019.
Article in Spanish | LILACS, CUMED | ID: biblio-1093077

ABSTRACT

Encontrar estrategias costo-efectivas para la rehabilitación y la educación del paciente con paraplejia, basado en sus necesidades, es menester para su abordaje integral, así como para la disminución de costos directos e indirectos. La telemedicina podría ser una herramienta adecuada. Este trabajo se propuso realizar una revisión crítica de la literatura sobre la utilidad de la telemedicina para la rehabilitación y el manejo del paciente con paraplejia, en el contexto de la Atención Primaria de Salud. Se realizó una búsqueda en las bases de datos PubMed, Medline y EMBASE, con descriptores tipo MeSH y DeCS. No se aplicó ningún filtro de temporalidad, idioma o grupo etario. Se reunieron 134 artículos. El criterio de búsqueda y de selección se basó en los elementos PICO. Luego del análisis de contenido de cada uno, se escogieron 29 artículos. El análisis crítico de la literatura se realizó por medio de los elementos PRISMA. La telemedicina y la telerrehabilitación son herramientas que pudieran ser útiles para pacientes parapléjicos o cuadripléjicos; sin embargo, no existe literatura ni evidencia sobre este tipo de intervenciones en esta población. Intervenciones en pacientes con enfermedades neurológicas diferentes a la paraplejia muestran que potencialmente la telemedicina podría tener beneficios y reducir costos en la rehabilitación. Las herramientas tecnológicas y de telemedicina en pacientes parapléjicos podrían favorecer potencialmente su rehabilitación y el uso eficiente de los recursos; no obstante, es necesaria la realización de estudios en el área, para determinar el beneficio real de la telemedicina como estrategia de Atención Primaria de Salud en el paciente con paraplejia y cuadriplejia(AU)


Finding cost-effective strategies for the rehabilitation and education of patients with paraplegia, based on their needs, is necessary for their comprehensive approach, as well as for the reduction of direct and indirect costs. The objective of this work was to perform a critical review of the literature on the usefulness of telemedicine for the rehabilitation and management of patients with paraplegia, in the context of Primary Health Care. A review of the literature in the PubMed, Medline and EMBASE databases was performed with MeSH and DeCS type descriptors. No filter of temporality, language or age group was applied. 134 articles were collected. The searching and selection criteria were based on the PICO elements; after the content analysis of each one, 29 articles were chosen. The critical analysis of the literature was carried out through the PRISMA elements. Telemedicine and telerehabilitation are tools that could be useful for paraplegic or quadriplegic patients; however, there is no literature or evidence on this type of interventions in this population. Interventions in patients with neurological diseases other than paraplegia show that telemedicine could potentially have benefits and reduce rehabilitation costs. The technological and telemedicine tools in paraplegic patients could potentially favor their rehabilitation and efficient use of resources; however, studies in the area are necessary to determine the real benefit of telemedicine as a care strategy primary health in the patient with paraplegia and quadriplegia(AU)


Subject(s)
Humans , Paraplegia , Primary Health Care , Quadriplegia , Disease , Health Strategies , Telemedicine
7.
Ciênc. Saúde Colet ; 24(6): 2341-2350, jun. 2019. tab
Article in Portuguese | LILACS | ID: biblio-1011811

ABSTRACT

Resumo Pesquisa objetivou investigar os fatores que interferem no retorno ao trabalho em indivíduos com paraplegia traumática e caracterizar o trabalho posterior à lesão, por meio de estudo epidemiológico do tipo transversal, sem inferência estatística. Participaram da pesquisa pacientes internados no Programa de Lesão Medular do Hospital Sarah de Reabilitação, Salvador. A análise descritiva usou média e desvio-padrão para variáveis contínuas e proporções para variáveis categóricas. Houve predomínio de homens entre os 42 pacientes entrevistados; a idade média foi de 36 anos. A escolaridade média foi de 9 anos. Retornaram ao trabalho 22 entrevistados, 21 deles inseridos no mercado de trabalho informal. A média de tempo para voltar a trabalhar foi de 3 anos. Principais motivos para voltar a trabalhar: necessidade de dinheiro, satisfação pessoal e contato com outras pessoas. O retorno ao trabalho mostra-se, neste estudo, relevante para o adulto com lesão medular, proporcionando-lhe maior rendimento e melhor qualidade de vida. Evidenciamos a importância de maior grau de escolaridade para o retorno ao trabalho bem sucedido. Portanto, é preciso aprimorar o processo de retorno ao trabalho, a qualificação e a reabilitação profissional desse trabalhador.


Abstract This research aimed to investigate the factors that affect the return to work of individuals with traumatic paraplegia and to characterize post-injury work by means of a cross-sectional epidemiological study without statistical inference. The participants were patients at the Spinal Cord Injury Program of the Sarah Rehabilitation Hospital, Salvador, Brazil. The descriptive analysis used mean and standard deviation for continuous variables and proportions for categorical variables. Male predominated among the 42 respondents, with a mean age of 36 years. Mean schooling years was 9 years. Twenty-two respondents returned to work, 21 of which were in the informal labor market. Mean time to return to work was 3 years. The main reasons for returning to work were need for money, personal satisfaction and contact with other people. In this study, returning to work is relevant for adults with spinal cord injury, providing them with higher income and better quality of life. We also noted the importance of higher education level for the successful return to work. Therefore, it is necessary to improve the return to work process, the qualification and professional rehabilitation of these workers.


Subject(s)
Humans , Male , Female , Adult , Paraplegia/rehabilitation , Spinal Cord Injuries/rehabilitation , Employment/statistics & numerical data , Return to Work/statistics & numerical data , Personal Satisfaction , Quality of Life , Brazil , Cross-Sectional Studies , Educational Status , Hospitals, Rehabilitation , Income , Middle Aged
8.
Int. j. morphol ; 37(2): 428-437, June 2019. tab, graf
Article in English | LILACS | ID: biblio-1002239

ABSTRACT

Oxidative stress and inflammation are the key players in the development of motor dysfunction post-spinal cord ischemic reperfusion injury (SC-IRI). This study investigated the protective effect of concomitant pre-administration of melatonin and alpha-tocopherol on the early complications (after 48 hours) of spinal cord IRI injury in rats. Melatonin or α-tocopherol were preadministered either individually or in combination for 2 weeks, then rats were exposed SC-IRI. Neurological examinations of the hind limbs and various biochemical markers of oxidative stress and inflammation in the SC tissue were assessed. Solely pre-administration of either melanin or α-tocopherol significantly but partially improved motor and sensory function of the hind limbs mediated by partial decreases in SC levels of MDA, AOPP and PGE2 levels and activities of SOD, partial significant decreases in plasma levels of total nitrate/nitrite and significant increases in AC activity of GSH-Px. However, combination therapy of both drugs resulted in the maximum improvements in all neurological assessments tested and biochemical endpoints. In conclusion, by their synergistic antioxidant and antiinflammatory actions, the combination therapy of melatonin and α-tocopherol alleviates SC-IRI induced paraplegia.


El estrés oxidativo y la inflamación son claves en el desarrollo de la disfunción motora posterior a lesión isquémica de la médula espinal (SC-IRI). Este estudio investigó acerca del efecto protector de la administración previa concomitante de la melatonina y alfa-tocoferol en las complicaciones tempranas (después de 48 horas) de la lesión de IRI de la médula espinal en ratas. La melatonina o el α-tocoferol se administraron individualmente o en combinación durante 2 semanas, luego las ratas fueron expuestas a SC-IRI. Se evaluaron los exámenes neurológicos de las miembros pélvicos y diversos marcadores bioquímicos de estrés oxidativo e inflamación en el tejido subcutáneo. Solo la administración previa de melatonina o α-tocoferol mejoró parcial y significativamente la función motora y sensorial de los miembros pélvicos mediadas por disminuciones parciales en los niveles de SC de los niveles de MDA, AOPP y PGE2 y las actividades de la SOD, disminuciones significativas parciales en los niveles plasmáticos del total nitrato / nitrito y aumentos significativos en la actividad de AC de GSH-Px. Sin embargo, se observaron los mejores resultados durante la combinación de ambos fármacos en todas las evaluaciones neurológicas y en los puntos finales bioquímicos. En conclusión, debido a sus acciones antioxidantes y antiinflamatorias sinérgicas, la terapia de melatonina y α-tocoferol alivia la paraplejía inducida por SC-IRI.


Subject(s)
Animals , Rats , Reperfusion Injury/drug therapy , Spinal Cord Ischemia/drug therapy , Melatonin/administration & dosage , Antioxidants/administration & dosage , Paraplegia , Spinal Cord/drug effects , Spinal Cord/pathology , Dinoprostone/blood , Rats, Sprague-Dawley , Oxidative Stress/drug effects , Tocopherols/pharmacology , Melatonin/pharmacology , Nitrites/blood , Antioxidants/pharmacology
9.
Psicol. ciênc. prof ; 39: e175434, jan.-mar.2019.
Article in Portuguese | LILACS-Express | LILACS, INDEXPSI | ID: biblio-1098511

ABSTRACT

Resumo A aquisição de uma deficiência pode ter extenso impacto na vida de uma pessoa, pois ocorre, muitas vezes, sob condições traumáticas e obriga tanto a ressignificações subjetivas quanto a adaptações práticas no cotidiano. O principal objetivo do trabalho aqui descrito consistiu em compreender aspectos psicossociais do processo de aquisição de uma deficiência, considerando diversos fatores que podem interferir nestas experiências. Para a realização da pesquisa, foram entrevistadas, de forma semiestruturada, 13 pessoas que adquiriram uma deficiência física, auditiva ou visual na idade adulta, sendo os relatos analisados pelo método de análise de conteúdo. Ao se discutir as falas dos pesquisados, são traçadas algumas semelhanças e distinções entre as experiências dos participantes, buscando também tecer considerações com base na literatura acadêmico-científica sobre o tema. Observou-se que os processos psicossociais de aquisição da deficiência foram permeados tanto por sentimentos negativos, relacionados à angústia e à depressão, bem como por reações mais harmônicas e de valorização da vida, em que se relativiza a perda do membro ou da capacidade sensorial. Representando um momento marcante na vida de quem a adquire, a deficiência pode levar à aprendizagem e ao amadurecimento, à medida que o tempo após a aquisição aumenta. Entende-se que os estudos acerca da deficiência, em especial a adquirida, devem ser ampliados e aprofundados, tendo em vista que o campo de estudos sobre esta temática ainda precisa de mais contribuições a respeito.


Abstract Becoming disabled may cause a considerable impact in someone's life, because, in most of the cases, it happens under traumatic conditions and it results in subjective resignification and practical adaptations. The main objective of this study is to understand the psychosocial aspects involved in becoming disabled, considering several factors which may interfere these experiences. For this research, 13 people who got a physical disability, a hearing or visual impairment in adulthood were interviewed in a semi-structured way and the results were evaluated using the content analysis method of Bardin (2011). When the speeches of the interviewed people are evaluated, some comparisons and distinctions among experiences of the participants are made for establishing relations with academic-scientific literature on this theme. It was noticed that the psychosocial processes involved in becoming disabled were permeated by negative feelings related to anguish and depression, as well as more harmonic reactions and valorization of life, in which the loss of a member or of a sensorial capability is relativized. As a defining moment in the lives of those who acquired it, the disability may result in learning and maturating over the years after the event. It is recommended that the studies concerning disability, especially the acquired ones, get broadened and deepened because there is a need for more contributions about this subject.


Resumen La adquisición de una discapacidad puede tener un amplio impacto en la vida de una persona, pues ocurre, muchas veces, bajo condiciones traumáticas y requiere tanto la reinterpretación subjetiva como las adaptaciones prácticas en la vida cotidiana. El principal objetivo del trabajo que se describe aquí fue entender los aspectos psicosociales del proceso de adquisición de una discapacidad, teniendo en cuenta diversos factores que pueden interferir en estas experiencias. Para la investigación, fueron entrevistadas de manera semiestructurada, 13 personas que adquirieron una discapacidad física, auditiva o visual en la edad adulta, siendo los relatos analizados por el método de análisis de contenido. En la discusión de los relatos de los entrevistados, son trazadas algunas similitudes y diferencias entre las experiencias de los participantes, buscando también tejer consideraciones con base en la literatura académica y científica sobre el tema. Se observó que los procesos psicosociales de adquisición de la discapacidad fueron permeados tanto por sentimientos negativos relacionados con la angustia y la depresión, así como por las reacciones más armónicas y de valorización de la vida, en que se relativiza la pérdida de un miembro o la capacidad sensorial. Representando un momento decisivo en la vida de quién la adquiere, la discapacidad puede llevar al aprendizaje y al crecimiento, a medida que el tiempo después de la adquisición aumenta. Se entiende que los estudios acerca de la discapacidad, en especial la adquirida, deben ser ampliados y profundizados, teniendo en cuenta que el campo de los estudios sobre este tema aún necesita más contribuciones al respecto.


Subject(s)
Humans , Adult , Paraplegia , Stereotyping , Vision Disorders , Wounds and Injuries , Disabled Persons , Adult , Deafness , Hearing , Hearing Loss , Personal Satisfaction , Rejection, Psychology , Psychological Distance , Social Isolation , Chronic Disease , Interpersonal Relations , Life Style , Motor Activity
10.
Rev. argent. cir. plást ; 25(1): 33-36, 20190000. fig
Article in Spanish | LILACS, BINACIS | ID: biblio-1358053

ABSTRACT

Introducción. La úlcera trocantérea es una de las lesiones por presión más frecuente y está asociada generalmente a bursitis, por lo que su tratamiento es complejo. Materiales y Métodos. Se presenta el caso de un paciente masculino de 29 años, con antecedente de lesión medular asociada a paraplejía fláccida con desarrollo de úlcera trocantérea derecha elíptica vertical. Fue abordado de forma multidisciplinaria y resuelto con resección de la patología y reconstrucción con colgajo musculocutáneo de fascia lata. Resultado. El paciente fue dado de alta al 21 día posoperatorio. No presentó dehiscencias, infecciones de la herida ni recidiva al cumplirse 6 meses de la cirugía y el resultado estético y funcional fue satisfactorio. Conclusión. El colgajo musculocutáneo de fascia lata ascendido y con cierre de V en Y es una opción segura, versátil y reproducible para la resolución de úlceras trocantéreas. Sin embargo, deben respetarse todos los pasos de la técnica para evitar así complicaciones y recidivas.


Background. Trochanteric ulcer is one of the most frequent pressure sore and is usually related with bursitis, therefore its treatment is complex. Material and Methods. We present a case of a 29 year-old male patient with medical history of spinalcord injury (SCI) related to flaccid paraplegia and the development of right trochanteric vertical elliptical sore. He was treated by a multidisciplinary team and solved by the resection of the pathology and immediate reconstruction with tensor fascia lata (TFL) musculo cutaneous flap. Results. The patient was discharged from the institution on the 21st postoperative day. With a follow-up of a 6 months period, complications such as wound infection, suture dehiscense or recurrence were not observed. Aesthetic and functional results were satisfactory. Conclusion. Ascended TFL flap with a V-Y closure is a reproducible, reliable and versatile procedure for the coverage of trochanteric pressure sore defects. However all surgical techniques tages must be considered in order to avoid complications and recurrence of the disease


Subject(s)
Humans , Male , Adult , Paraplegia/surgery , Bursitis/therapy , Reconstructive Surgical Procedures/methods , Pressure Ulcer/therapy , Fascia Lata/transplantation , Femur/injuries , Free Tissue Flaps/transplantation , Wound Closure Techniques
11.
Rev. argent. cir. plást ; 25(1): 16-20, 20190000. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1358037

ABSTRACT

Propósito y objetivo. Demostrar una de las opciones más empleadas para la cobertura de úlceras isquiáticas en paciente parapléjico. El colgajo glúteo mayor sería de primera elección en el caso presentado de una paciente con diagnóstico de escaras isquiáticas bilateral Grado IV. Introducción. El colgajo glúteo mayor, colgajo musculocutáneo, es un procedimiento muy utilizado y de primera línea para el tratamiento de úlceras isquiáticas. Debemos tener en cuenta que para el éxito y buena evolución de la cirugía es necesario la conformación de un equipo multidisciplinario, para su seguimiento y control. Las opciones de cobertura dependen de la topografía de la lesión. Algunas de las opciones de cobertura son: colgajo glúteo inferior de rotación, colgajo glúteo inferior de avance en V-Y, colgajo de isquiotibiales en V-Y, colgajo de cara posterior de muslo y colgajo extendido de fascia lata, entre otros. Material y método. Se presenta el caso clínico de una paciente femenina con diagnóstico patológico de cavernoma intramedular D9, que padece paraplejía de un año de evolución, presentando escara isquiática bilateral grado IV acompañadas de osteomielitis. Se trató quirúrgicamente con colgajo glúteo mayor bilateral Resultados. En esta paciente se alcanzó una adecuada cobertura del defecto, que permitió su pronta rehabilitación, y un minucioso control posoperatorio que no mostró complicaciones ni recidiva, hasta la fecha. Discusión. Las úlceras isquiáticas profundas ubicadas cerca del tracto genitourinario presentan mayor dificultad para su reconstrucción. El colgajo musculocutáneo de glúteo mayor a pedículo inferior permite el cierre de cualquier úlcera isquiática y el cierre primario del sitio donador asegurando un cierre sin tensión; otras opciones quirúrgicas, como los colgajos basados en la pelvis o el tronco, son menos susceptibles a la tensión que aquellos ubicados en la porción móvil de la extremidad inferior, por lo que los colgajos de glúteo mayor, inferior y de cara posterior al muslo tienen mayor porcentaje de éxito que los colgajos de tensor de fascia lata e isquiotibiales. Conclusión. El colgajo glúteo mayor es un tratamiento de primera elección para la cobertura de úlceras isquiáticas de alta morbilidad en pacientes parapléjicos, tratado por un equipo multidisciplinario, cuya técnica quirúrgica presentó buena cobertura con un control estricto del posoperatorio con excelente evolución y sin ninguna complicación esperada


Subject(s)
Humans , Female , Adult , Paraplegia/drug therapy , Sciatica/pathology , Surgical Flaps/blood supply , Buttocks/surgery , Aftercare , Reconstructive Surgical Procedures/methods , Pressure Ulcer/surgery , Ischemia/therapy
12.
Article in Chinese | WPRIM | ID: wpr-771964

ABSTRACT

OBJECTIVE@#To detect pathogenic variation in a pedigree affected with hereditary spastic paraplegia type 31 and explore its molecular pathogenesis.@*METHODS@#Customized Roche NimbleGen capture probes were used to capture all exons of the target genes in relation with hereditary spastic paraplegia. The DNA samples were also assayed with fluorescent quantitative PCR as well as chromosomal microarray analysis using CytoScan HD chip.@*RESULTS@#The proband and her father and grandfather were found to carry a deletion for position 85 992 693-86 842 693 on chromosome 2, which spanned approximately 900 kb and encompassed the REEP1 gene. The latter has been specifically associated with hereditary spastic paraplegia type 31. The same deletion was not found in her mother who is phenotypically normal.@*CONCLUSION@#The deletional variation of the REEP1 gene probably underlies the disease in this pedigree.


Subject(s)
Female , Humans , Membrane Transport Proteins , Paraplegia , Pedigree , Sequence Deletion , Spastic Paraplegia, Hereditary , Genetics
13.
Asian Spine Journal ; : 577-583, 2019.
Article in English | WPRIM | ID: wpr-762971

ABSTRACT

STUDY DESIGN: A quasi-experimental single-blinded study. PURPOSE: To investigate the effects of ‘graded exercise integrated with education’ on physical fitness, exercise self-efficacy (ESE), and physical activity (PA) levels among subacute and chronic wheelchair-dependent paraplegia patients. OVERVIEW OF LITERATURE: Most of the chronic spinal cord injury (SCI) patients had low physical fitness due to a sedentary lifestyle and lack of ESE after discharge from a rehabilitation program. Education may encourage them to engage with exercise to regain and maintain their physical fitness. However, there is a lack of research to support the effects of exercise integrated with education after an SCI. METHODS: A total of 44 participants will be assigned to either the experimental group (graded exercise integrated with education) or active control (conventional physical therapy). The experimental group will receive graded strength and aerobic exercise training according to their progression criteria. They will attend an education program during and after the rehabilitation program. The control group will only receive conventional physical therapy during their in-rehabilitation program. This study will be conducted during a period of 16 weeks, consisting of 8 weeks of in-rehabilitation and 8 weeks post-rehabilitation. Statistical analysis will be performed using the IBM SPSS ver. 21.0 (IBM Corp., Armonk, NY, USA) at a significance level of p≤0.05. RESULTS: The primary outcome measures will be upper-limb isokinetic strength, isometric grip strength, and cardiorespiratory fitness. The secondary outcomes will be ESE and PA levels. CONCLUSIONS: An intervention that combines exercise training and education may be warranted to enhance the physical fitness, ESE, and PA levels in SCI patients. This trial was registered with ClinicalTrials.gov (NCT03420170).


Subject(s)
Education , Exercise , Hand Strength , Health Education , Humans , Motor Activity , Non-Randomized Controlled Trials as Topic , Outcome Assessment, Health Care , Paraplegia , Physical Fitness , Rehabilitation , Sedentary Behavior , Self Efficacy , Spinal Cord Injuries , Spinal Cord , Spine
14.
Article in English | WPRIM | ID: wpr-719398

ABSTRACT

A 65-year-old male patient underwent C-arm fluoroscopy-guided bilateral celiac plexus neurolysis to relieve peritoneal seeding-related pain associated with pancreatic cancer. Following confirmation of spreading, and no intravascular injection of contrast media, 7.5 ml of 0.25% chirocaine was injected in each side. The pain subsided after the block, with no motor or sensory deficits. Subsequently, celiac plexus neurolysis with 99.8% alcohol was performed using a posterolateral approach under fluoroscopic guidance. The patient was instructed to maintain a prone position for 2 hours while the procedure was performed. Approximately 4 hours later, the patient experienced paralysis of both lower extremities and hypoesthesia. Emergent magnetic resonance imaging of the thoracic and lumbar spine revealed gray matter signal change in the cord and conus medullaris at the T10-L1 level, and decreased perfusion at the T11-T12 vertebral bodies, suggesting spinal cord infarction. The patient remained paraplegic until his death 24 days later.


Subject(s)
Aged , Celiac Plexus , Contrast Media , Gray Matter , Humans , Hypesthesia , Infarction , Lower Extremity , Magnetic Resonance Imaging , Male , Pancreatic Neoplasms , Paralysis , Paraplegia , Perfusion , Prone Position , Spinal Cord , Spine
15.
Article in English | WPRIM | ID: wpr-719396

ABSTRACT

BACKGROUND: The clinical outcomes and safety of thoracic epidural catheterization in anesthetized adult patients has not yet been established. The purpose of this study was to compare clinical differences between epidural catheterization performed before and after anesthesia for postoperative pain control. METHODS: The medical records of 549 patients who received thoracic epidural catheterization before (awake group, n = 303) or after (anesthetized group, n = 246) induction of anesthesia for major abdominal surgery were reviewed retrospectively. RESULTS: The catheter insertion time (1.6 ± 1.5 vs. 1.1 ± 1.2 min; 95% confidence interval [95% CI], 0.3–0.8; effect size, 0.368; P < 0.001) and number of attempts required for successful epidural catheterization (1 [1, 3] vs. 1 [1, 2], P = 0.003) were increased in the awake group. The incidence rates of dural puncture, vascular injury and postoperative paresthesia were similar between the two groups. The median surgical site numerical rating scale pain score (0 = no pain, 10 = worst pain imaginable) was lower in the awake group than in the anesthetized group (3 vs. 4 on postoperative day 1, P < 0.001; and 2 vs. 3 on postoperative day 3, P = 0.002). Serious complications, including meningitis, epidural abscess, epidural hematoma, spinal cord injury, and paraplegia, were not observed in either group. CONCLUSIONS: Successful epidural catheterization before induction of anesthesia required more attempts versus after anesthesia. Overall complication rates of thoracic epidural catheterization were similar regardless of the timing of the procedure.


Subject(s)
Adult , Analgesia, Epidural , Anesthesia , Catheterization , Catheters , Epidural Abscess , Hematoma, Epidural, Spinal , Humans , Incidence , Medical Records , Meningitis , Pain, Postoperative , Paraplegia , Paresthesia , Postoperative Complications , Punctures , Retrospective Studies , Vascular System Injuries
16.
Experimental Neurobiology ; : 679-696, 2019.
Article in English | WPRIM | ID: wpr-785789

ABSTRACT

Spinal cord injury (SCI) causes axonal damage and demyelination, neural cell death, and comprehensive tissue loss, resulting in devastating neurological dysfunction. Neural stem/progenitor cell (NSPCs) transplantation provides therapeutic benefits for neural repair in SCI, and glial cell line-derived neurotrophic factor (GDNF) has been uncovered to have capability of stimulating axonal regeneration and remyelination after SCI. In this study, to evaluate whether GDNF would augment therapeutic effects of NSPCs for SCI, GDNF-encoding or mock adenoviral vector-transduced human NSPCs (GDNF-or Mock-hNSPCs) were transplanted into the injured thoracic spinal cords of rats at 7 days after SCI. Grafted GDNF-hNSPCs showed robust engraftment, long-term survival, an extensive distribution, and increased differentiation into neurons and oligodendroglial cells. Compared with Mock-hNSPC- and vehicle-injected groups, transplantation of GDNF-hNSPCs significantly reduced lesion volume and glial scar formation, promoted neurite outgrowth, axonal regeneration and myelination, increased Schwann cell migration that contributed to the myelin repair, and improved locomotor recovery. In addition, tract tracing demonstrated that transplantation of GDNF-hNSPCs reduced significantly axonal dieback of the dorsal corticospinal tract (dCST), and increased the levels of dCST collaterals, propriospinal neurons (PSNs), and contacts between dCST collaterals and PSNs in the cervical enlargement over that of the controls. Finally grafted GDNF-hNSPCs substantially reversed the increased expression of voltage-gated sodium channels and neuropeptide Y, and elevated expression of GABA in the injured spinal cord, which are involved in the attenuation of neuropathic pain after SCI. These findings suggest that implantation of GDNF-hNSPCs enhances therapeutic efficiency of hNSPCs-based cell therapy for SCI.


Subject(s)
Animals , Axons , Cell Death , Cell Movement , Cell- and Tissue-Based Therapy , Cicatrix , Demyelinating Diseases , gamma-Aminobutyric Acid , Glial Cell Line-Derived Neurotrophic Factor , Humans , Hyperalgesia , Myelin Sheath , Neuralgia , Neurites , Neuroglia , Neurons , Neuropeptide Y , Paraplegia , Pyramidal Tracts , Rats , Regeneration , Spinal Cord Injuries , Spinal Cord , Therapeutic Uses , Transplants , Voltage-Gated Sodium Channels
17.
Article in English | WPRIM | ID: wpr-741208

ABSTRACT

Primary central nervous system lymphoma of T-cell origin (T-PCNSL) is rare, and its clinicopathological features remain unclear. Peripheral T-cell lymphoma of γδ T-cell origin is an aggressive lymphoma mainly involving extranodal sites. Here, we report a case of γδ T-PCNSL involving the intramedullary spinal cord and presenting with paraplegia. A 75-year-old Korean woman visited the hospital complaining of back pain and lower extremity weakness. Magnetic resonance imaging revealed multifocal enhancing intramedullary nodular lesions in the thoracic and lumbar spinal cord. An enhancing nodular lesion was observed in the periventricular white matter of the lateral ventricle in the brain. There were no other abnormalities in systemic organs or skin. Laminectomy and tumor removal were performed. The tumor consisted of monomorphic, medium-to-large atypical lymphocytes with pale-to-eosinophilic cytoplasm. Immunohistochemically, the tumor cells were CD3(+), TCRβF1(-), TCRγ(+), CD30(-), CD4(-), CD8(-), CD56(+), TIA1(+), granzyme B(+), and CD103(+). Epstein-Barr virus in situ was negative. This case represents a unique T-PCNSL of γδ T-cell origin involving the spinal cord.


Subject(s)
Aged , Back Pain , Brain , Central Nervous System , Cytoplasm , Female , Granzymes , Herpesvirus 4, Human , Humans , Laminectomy , Lateral Ventricles , Lower Extremity , Lymphocytes , Lymphoma , Lymphoma, T-Cell , Lymphoma, T-Cell, Peripheral , Magnetic Resonance Imaging , Paraplegia , Skin , Spinal Cord Diseases , Spinal Cord , T-Lymphocytes , White Matter
18.
Rev. bras. cir. plást ; 33(4): 595-598, out.-dez. 2018. ilus
Article in Portuguese | LILACS | ID: biblio-980169

ABSTRACT

Úlceras de pressão são alterações da integridade da pele e tecidos subjacentes, causadas por pressão, mais usualmente sobre proeminências ósseas, especialmente em áreas desprovidas de sensibilidade, levando à necrose e ulceração. Dados da literatura internacional estimam que 3 a 14% dos pacientes hospitalizados desenvolvem úlceras de pressão. Descrevemos a correção simultânea de úlceras sacral e isquiática extensas em paciente paraplégico jovem utilizando retalho fasciomiocutâneo de glúteo máximo e de face posterior da coxa.


Pressure ulcers are alterations of the integrity of the skin and underlying tissues, caused by pressure, more commonly on bony prominences, especially in areas devoid of sensitivity, which lead to necrosis and ulceration. Data from the international literature estimate that 3­14% of hospitalized patients develop pressure ulcers. We herein describe the simultaneous correction of extensive sacral and ischial ulcers in a young paraplegic patient, using a gluteus maximus fasciomyocutaneous flap from the posterior aspect of the thigh.


Subject(s)
Humans , Male , Adult , Paraplegia/surgery , Paraplegia/complications , Pressure Ulcer/surgery , Pressure Ulcer/complications , Myocutaneous Flap/surgery , Myocutaneous Flap/adverse effects , Necrosis/surgery , Risk Factors , Muscle Spasticity
19.
Psicol. ciênc. prof ; 38(4): 730-743, out.-dez. 2018.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-976562

ABSTRACT

Resumo: Os sujeitos com paraplegia adquirida são submergidos a diversas limitações presentes em um corpo até então representado como íntegro em suas funções, demonstrando o desamparo e a ruptura que a nova condição repercute. Diante disso, buscou-se compreender como ocorre a reconstrução da imagem corporal pelos sujeitos na paraplegia adquirida, bem como, os significados atribuídos a esta vivência. Foi realizada a pesquisa descritiva e exploratória, de cunho qualitativo, desenvolvida com oito pessoas que adquiriram a paraplegia na fase adulta, com base em entrevistas semiestruturadas e análise de conteúdo. Compreendeu-se que os entrevistados se defrontam com o desconhecido, perpassando conflitivas na vivência com o corpo antigo e atual. Dessa forma, sentimentos de revolta e angústia frente à nova condição figuram o difícil processo de luto na paraplegia e suas implicações psíquicas. Frente a isso, perpassa-se, em muitos casos, a reintegração da nova imagem, podendo construir sentidos e nova identidade ao sujeito, contudo, em alguns casos, esse processo é dificultado. Assim, entende-se que a vivência da paraplegia é singular e complexa, sentida como um abalo à identidade, sendo importante como auxiliador da reconstrução da imagem corporal, o amparo dos profissionais de saúde na criação de estratégias para lidar com os abalos e as angústias ante a nova condição....(AU)


Abstract: Subjects with acquired paraplegia face different limitations in a body that, until then, was expressed intact in its functions, demonstrating the helplessness and the rupture that the new condition reverberates. Therefore, we sought to understand how subjects with acquired paraplegia reconstruct their body image, as well as to understand the meanings they attribute to this experience. This is a descriptive and exploratory qualitative study with eight people who acquired paraplegia in the adult phase, based on semi-structured interviews and content analysis. Interviewees are confronted with the unknown, passing through conflicts related to the experience with the previous and the current body. In this way, feelings of revolt and anguish in the face of the new condition include the difficult process of mourning in paraplegia and its psychic implications. Facing this, in many cases, the reintegration of the new image can build senses and new identity to the subject; however, in some cases, this process is difficult. Thus, the experience of paraplegia is singular and complex, felt as a shock to the identity, being important, as a helper for the reconstruction of the body image, the support of healthcare professionals in building strategies to deal with the shocks and anguish associated with facing this new condition....(AU)


Resumen: Los sujetos con paraplejia adquirida se sumergen a diferentes limitaciones en un cuerpo, hasta entonces, representado como íntegro en sus funciones, demostrando el desamparo y la rotura que la nueva condición repercute. Ante ello, se buscó comprender cómo ocurre la reconstrucción de la imagen corporal por sujetos en paraplejia adquirida, así como los significados atribuidos a esa vivencia. Se realizó una investigación descriptiva y exploratoria, de cuño cualitativo, desarrollada con ocho personas que adquirieron la paraplejia en la fase adulta, con base en entrevistas semiestructuradas y análisis de contenido. Se comprendió que los entrevistados se enfrentan a lo desconocido, atravesando conflictos en la experiencia con el cuerpo antiguo y el actual. De esa forma, sentimientos de revuelta y angustia frente esta nueva condición figuran el difícil proceso de luto en la paraplejia y sus implicaciones psíquicas. Frente a eso, se pasa, en muchos casos, a la reintegración de la nueva imagen, pudiendo construir sentidos y nueva identidad al sujeto, sin embargo, en algunos casos, ese proceso es dificultado. Así, se entiende que la vivencia de la paraplejia es singular y compleja, sentida como un golpe a la identidad, siendo importante como auxiliador de la reconstrucción de la imagen corporal, el amparo de los profesionales de salud en la creación de estrategias para lidiar con los sacudones y las angustias frente a la nueva condición....(AU)


Subject(s)
Humans , Male , Female , Paraplegia , Body Image , Post Disaster Reconstruction , Bereavement
20.
Pesqui. vet. bras ; 38(8): 1656-1663, Aug. 2018. tab, graf
Article in Portuguese | LILACS, VETINDEX | ID: biblio-976468

ABSTRACT

Este estudo retrospectivo incluiu cães paraplégicos com ausência de percepção a dor profunda secundário a doença do disco intervertebral toracolombar e submetidos à cirurgia descompressiva. Teve como objetivo comparar a recuperação funcional e a qualidade de vida (QV) quando submetidos a um protocolo em um centro especializado ou a domicílio realizado pelo tutor. Vinte e oito cães foram distribuídos no grupo A (GA) e submetidos ao protocolo domiciliar e 38 denominados grupo B (GB) em um centro especializado. Recuperaram a habilidade de caminhar 43% dos cães em uma média de 40 dias de pós-operatório (PO) no GA e 42% em uma média de 36 dias no GB. Em 53% dos casos (35/66) os cães permaneceram paraplégicos sem percepção a dor profunda ao final do período de 90 dias de PO. Vinte e cinco tutores do GA e 26 do GB responderam um questionário sobre a QV, com no mínimo seis meses de PO. A avaliação do tempo de sobrevida dos animais, realização de eutanásia e nota atribuída a QV demonstraram que os cães do GB provavelmente foram beneficiados pelo estreito acompanhamento e orientação aos tutores até 90 dias PO.(AU)


The retrospective study included paraplegic dogs affected by thoracolumbar intervertebral disc disease with absence of deep pain perception and submitted to a decompressive surgical technique. The aim was to compare functional recovery and quality of life (QOL) of dogs that underwent a home physiotherapy protocol to dogs that were cared in a specialized center. Twenty-eight dogs were placed in group A (GA, home physiotherapy protocol) and other 38 patients were placed in group B (GB, physiotherapy protocol in a specialized center). Forty three percent (43%) of the patients recovered the ability to walk in an average of 40 postoperative (PO) days in GA and 42% in an average of 36 days in GB. In 53% of the cases (35/66) the dogs remained paraplegic without deep pain perception at the end of physiotherapeutic protocols. Twenty-five owners from GA and 26 from GB answered a questionnaire about QOL, with a minimum of six PO months. The evaluation of the animals survival time, euthanasia and the QOL score demonstrated that dogs that underwent a physiotherapeutic treatment in a specialized center probably were benefited by the close monitoring and orientation to owners until 90 days of PO.(AU)


Subject(s)
Animals , Dogs , Paraplegia/veterinary , Physical Therapy Specialty , Dogs/abnormalities , Dogs/surgery
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