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1.
Rev. ADM ; 78(2): 106-114, mar.-abr. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1247959

ABSTRACT

Las estrategias para el éxito en la rehabilitación bucal requieren de la interrelación de varias disciplinas que en conjunto logren resultados predecibles y duraderos. La visión individualizada de cada área de especialidad puede conllevar a no ofrecer la mejor alternativa de tratamiento, es por ello que la valoración, el diagnóstico y la planificación del caso clínico debe ser realizada por un equipo interdisciplinario para evitar esta situación y crear una sinergia en donde el «todo sea mayor que la suma de sus partes¼. El objetivo de este trabajo es presentar un caso clínico en el cual intervinieron varias áreas de especialidad: periodoncia, prostodoncia, cirugía oral y patología bucal, logrando devolver la función y la estética a través del manejo interdisciplinario (AU)


The strategies for success in oral rehabilitation require the interrelation of several disciplines, which together, achieve predictable and lasting results. The individualized view of each specialty area may lead to not offering the best treatment alternative, which is why the assessment, diagnosis, and planning of the clinical case must be carried out by an interdisciplinary team to avoid this situation and create a synergy in where the «whole is greater than the sum of its parts¼. The objective of this work is to present a clinical case where several areas of specialty intervened: periodontics, prosthodontics, oral surgery, and oral pathology, thus achieving the return of function and aesthetics through interdisciplinary management (AU)


Subject(s)
Humans , Female , Middle Aged , Patient Care Team , Oral Surgical Procedures, Preprosthetic/methods , Mouth Rehabilitation , Periodontitis/therapy , Schools, Dental , Patient Satisfaction , Photography, Dental , Advance Care Planning , Denture, Complete, Immediate , Esthetics, Dental , Alveolar Ridge Augmentation/methods , Labial Frenum/surgery , Mexico
2.
Article in English | WPRIM | ID: wpr-887756

ABSTRACT

OBJECTIVES@#To compare the treatment effects of periodontal endoscope-assisted and traditional subgingival scaling on residual pockets.@*METHODS@#A total of 13 patients with periodontitis from Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University were recruited. After 4-6 weeks of initial treatment, the residual pockets with a probing depth (PD) of ≥4 mm and attachment loss (AL) of ≥4 mm and bleeding on probing were examined with traditional (control group) and periodontal endoscope-assisted subgingival scaling (endoscopy group) in a randomly controlled split-mouth design. At baseline and 6 weeks and 3 months after treatment, plaque index (PLI), PD, AL, and bleeding index (BI) were measured. Differences in these clinical parameters within and between groups and patient-reported outcomes were compared.@*RESULTS@#A total of the 694 sites of 251 teeth were included in this trial. Both groups showed significant improvement in each periodontal parameters 6 weeks and 3 months after treatment (@*CONCLUSIONS@#Periodontal endoscope-assisted subgingival scaling resulted in better effects than traditional subgingival scaling when the residual pockets were in a single-rooted tooth, with a PD of ≥5 mm but without vertical alveolar bone resorption and furcation involvement.


Subject(s)
Dental Plaque Index , Dental Scaling , Endoscopes , Humans , Periodontitis/therapy
3.
Rev. Fac. Odontol. (B.Aires) ; 36(83): 57-66, 2021. ilus
Article in Spanish | LILACS | ID: biblio-1343658

ABSTRACT

El objetivo de este reporte de caso clínico es presentar una rehabilitación integral adhesiva resuelta por alumnos de grado de la Facultad de Odontología de la Universidad de Buenos Aires (FOUBA), bajo un protocolo de abordaje terapéutico que simplifica su realización. Esta sistematización hace foco en un abordaje completamente aditivo con la finalidad de devolver la salud, la función y la estética de manera predecible. Un paciente de 55 años concurrió a la consulta por motivos estéticos. En el diagnóstico se evidenciaron desgastes severos producto de la parafunción. Se realizó una rehabilitación oral adhesiva seleccionando a la cerámica vítrea como material restaurador. El diagnóstico y la comprensión de su etiología son fundamentales para realizar un tratamiento conservador con restauraciones adheridas y con alto grado de predictibilidad, que se prolongará en el tiempo, gracias a la utilización de una placa orgánica y a los controles de mantenimiento correspondientes (AU)


Subject(s)
Humans , Male , Middle Aged , Bruxism/rehabilitation , Ceramics , Dental Bonding , Esthetics, Dental , Patient Care Planning , Periodontitis/therapy , Argentina , Schools, Dental , Dental Cavity Preparation , Conservative Treatment , Inlays , Mouth Rehabilitation
4.
Article in English | WPRIM | ID: wpr-922470

ABSTRACT

Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, have hampered their clinical application. These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system. However, the potential function of MSC-exos produced by 3D culture (3D-exos) in periodontitis remains elusive. This study showed that compared with MSC-exos generated via 2D culture (2D-exos), 3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17 (Th17) cell/Treg balance in inflamed periodontal tissues. Mechanistically, 3D-exos exhibited greater enrichment of miR-1246, which can suppress the expression of Nfat5, a key factor that mediates Th17 cell polarization in a sequence-dependent manner. Furthermore, we found that recovery of the Th17 cell/Treg balance in the inflamed periodontium by the local injection of 3D-exos attenuated experimental colitis. Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium.


Subject(s)
Colitis , Exosomes , Humans , Periodontitis/therapy , Periodontium , T-Lymphocytes, Regulatory , Th17 Cells
5.
J. appl. oral sci ; 28: e20190694, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1134777

ABSTRACT

Abstract Objective Obesity is a chronic disease that negatively affects an individual's general and oral health. The present study aimed to compare the clinical and microbiological effects of non-surgical periodontal therapy with the full mouth disinfection (FMD) protocol on obese and non-obese individuals at 9 months post-therapy. Methodology This clinical study was first submitted and approved by the Ethics Committee. Fifty-five obese patients and 39 non-obese patients with periodontitis were evaluated. The full-mouth periodontal clinical parameters, clinical attachment level (CAL), probing depth (PD), gingival index (GI), and plaque index (PI), were monitored at baseline, 3, 6, and 9 months after periodontal treatment with full mouth disinfection (FMD) protocol. The mean count of Tannerella forsythia , Porphyromonas gingivalis , Treponema Denticola , and Aggregatibacter actinomycetemcomitans was determined by quantitative polymerase chain reaction on subgingival biofilm samples. Demographic data were assessed by Chi-square test. For clinical and microbiological parameters, two-factor repeated-measures ANOVA was used. Results In both groups, periodontal therapy using the one-stage full-mouth disinfection protocol significantly improved CAL, PD, GI, and PI (p<0.05). Obese and non-obese patients equally responded to non-surgical periodontal therapy (p>0.05). Microbial count found no major differences (p>0.05) between obese and non-obese individuals who had undergone non-surgical periodontal therapy. Conclusions Obesity did not affect the clinical and microbiological outcomes of non-surgical periodontal therapy.


Subject(s)
Humans , Male , Female , Adult , Periodontitis/microbiology , Periodontitis/therapy , Obesity/microbiology , Time Factors , Periodontal Index , Anthropometry , Dental Plaque Index , Prospective Studies , Risk Factors , Analysis of Variance , Longitudinal Studies , Treatment Outcome , Aggregatibacter actinomycetemcomitans/isolation & purification , Porphyromonas gingivalis/isolation & purification , Statistics, Nonparametric , Treponema denticola/isolation & purification , Tannerella forsythia/isolation & purification , Middle Aged , Obesity/physiopathology
6.
J. appl. oral sci ; 28: e20190248, 2020. graf
Article in English | LILACS, BBO | ID: biblio-1056591

ABSTRACT

Abstract The evidence is inconclusive regarding the effect of periodontal treatment on glycemic control and systemic inflammation in patients with type 2 diabetes (T2D) and periodontitis Objective: To evaluate the effect of scaling and root planing (SRP) on the metabolic control and systemic inflammation of patients with type 2 diabetes (T2D). Methodology: A literature search was conducted using the MEDLINE database via PubMed and the Cochrane Central Register of Controlled Trials, from their oldest records up to July 2018. Only randomized clinical trials (RCT) were considered eligible for evaluating the effect of periodontal treatment on markers of metabolic control [glycated hemoglobin (HbA1C)] and systemic inflammation [C-reactive protein (CRP)] in patients with T2D. The quality of the studies was evaluated using the Cochrane Collaboration risk assessment tool. Meta-analyses were performed for HbA1c and CRP using random effects models. The size of the overall intervention effect was estimated by calculating the weighted average of the differences in means (DM) between the groups in each study. Heterogeneity was assessed using the Q-statistic method (x2 and I²). The level of significance was established at p<0.05. Results: Nine RCT were included. SRP was effective in reducing HbA1c [DM=0.56 (0.36-0.75); p<0.01] and CRP [DM=1.89 (1.70-2.08); p<0.01]. No heterogeneity was detected (I2=0%, p>0.05). Conclusions: SRP has an impact on metabolic control and reduction of systemic inflammation of patients with T2D.


Subject(s)
Humans , Periodontitis/physiopathology , Periodontitis/therapy , Dental Scaling/methods , Root Planing/methods , Diabetes Mellitus, Type 2/physiopathology , Diabetes Mellitus, Type 2/prevention & control , C-Reactive Protein/analysis , Glycated Hemoglobin A/analysis , Treatment Outcome , Publication Bias
7.
Braz. oral res. (Online) ; 34: e030, 2020. tab, graf
Article in English | LILACS | ID: biblio-1089389

ABSTRACT

Abstract: The abnormal increase in proliferation rate of human periodontal ligament stem cells (PDLSCs) is considered to be involved in the pathogenesis of periodontitis, a disease in which the IL-10-mediated anti-inflammatory pathway plays a critical role. This study aimed to investigate the involvement of microRNA-466l in periodontitis and to explore the possible interaction between IL-10 and microRNA-466l. PDLSCs were obtained from periodontitis-affected teeth and healthy control teeth. The expression of microRNA-466l and IL-10 mRNA was measured in PDLSCs using RT-qPCR. The proliferation ability of PDLSCs was analyzed using CCK-8 assays. Overexpression of microRNA-466l in a PDLSC cell line was established using two different types of PDLSCs, and the effect of microRNA-466l overexpression on IL-10 expression and cell proliferation were detected by western blot and CCK-8 assays, respectively. We found that expression levels of microRNA-466l and IL-10 mRNA were significantly lower (P < 0.05) in PDLSCs derived from periodontitis-affected teeth compared to those derived from healthy teeth. However, the cell proliferation ability was significantly higher in the PDLSCs derived from periodontitis-affected teeth. Meanwhile microRNA-466l overexpression decreased cell proliferation rates of both types of PDLSCs and upregulated IL-10 expression. Together, these data suggest that microRNA-466l can upregulate IL-10 and reduce the proliferation rate of PDLSCs.


Subject(s)
Humans , Adult , Periodontitis/genetics , Stem Cells/metabolism , Up-Regulation , Interleukin-10/therapeutic use , MicroRNAs/metabolism , Cell Proliferation/physiology , Periodontitis/metabolism , Periodontitis/therapy , Cell Differentiation , Blotting, Western , Interleukin-10/metabolism
8.
Braz. oral res. (Online) ; 34(supl.1): e027, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1098124

ABSTRACT

Abstract: Periodontal diseases are considered a worldwide public health problem, owing to their high prevalence in developed and developing countries. Periodontitis may lead to tooth loss, which can impact oral health-related quality of life. Gingivitis and periodontitis have been extensively studied regarding their etiopathogenesis, epidemiology, prevention and treatment outcomes. However, most of these aspects are studied and discussed globally, which may hamper a clear interpretation of the findings and the design of effective plans of action for specific regions or populations. For example, in Latin America, epidemiological data about the distribution of periodontal diseases is still scarce, mainly when it comes to nationwide representative samples. This Consensus aimed to address the following topics related to periodontal diseases in Latin America: a) The impact of the global burden of periodontal diseases on health: a global reality; b) Periodontal diseases in Latin America; c) Strategies for the prevention of periodontal diseases in Latin America; d) Problems associated with diagnosis of periodontal conditions and possible solutions for Latin America; e) Treatment of Periodontitis. This consensus will help to increase awareness about diagnosis, prevention and treatment of periodontal diseases, in the context of Latin American countries.


Subject(s)
Humans , Male , Female , Periodontal Diseases/therapy , Consensus Development Conferences as Topic , Periodontal Diseases/diagnosis , Periodontal Diseases/epidemiology , Periodontitis/diagnosis , Periodontitis/therapy , Periodontitis/epidemiology , Quality of Life , Oral Health , Global Burden of Disease , Gingivitis , Gingivitis/diagnosis , Gingivitis/epidemiology , Latin America/epidemiology
9.
Braz. oral res. (Online) ; 34(supl.1): e026, 2020.
Article in English | LILACS, BBO | ID: biblio-1098123

ABSTRACT

Abstract: Gingivitis and periodontitis are associated with a negative impact on Oral Health Related Quality of Life (OHRQoL), exerting a significant influence on aspects related to the patients' function and esthetics. Periodontitis has been associated with several systemic conditions, including adverse pregnancy outcomes, cardiovascular diseases, type 2 diabetes mellitus (DM), respiratory disorders, fatal pneumonia in hemodialysis patients, chronic renal disease and metabolic syndrome. The aim of this paper was to review the results of different periodontal treatments and their impacts on patients' OHRQoL and systemic health. Non-surgical and surgical periodontal treatments are predictable procedures in terms of controlling infection, reducing probing pocket depth and gaining clinical attachment. In addition, the treatment of periodontitis may significantly improve OHRQoL and promote a reduction in the levels of systemic markers of inflammation, including some cytokines associated with cardiovascular diseases. Studies have also suggested that periodontal treatment may improve glycemic control in patients with DM. Strategies and actions for preventing the onset and recurrence of periodontitis, and the challenges facing the field of periodontology in the XXI century are presented in this review.


Subject(s)
Humans , Periodontitis/physiopathology , Periodontitis/therapy , Periodontics/trends , Quality of Life , Cardiovascular Diseases/physiopathology , Cardiovascular Diseases/prevention & control , Oral Health , Diabetes Mellitus, Type 2/physiopathology , Diabetes Mellitus, Type 2/prevention & control , Latin America
10.
Int. j. odontostomatol. (Print) ; 13(4): 442-445, dic. 2019. tab, graf
Article in English | LILACS | ID: biblio-1056482

ABSTRACT

ABSTRACT: The objective of this study was to determine the effect of the subgingival irrigation of chlorhexidine 0.12 % of the total anaerobic microbiota. Microbial sampling to 30 subjects with periodontitis stage II Grade B, in pockets with a periodontal probing depth > 4 mm. The subgingival irrigation was made with 5 mL of chlorhexidine in the test group and with 5 mL of distilled water in the control group. 24 hours after the procedure was obtained a second sample to compare. It was found that the subgingival irrigation with chlorhexidine at 0.12 % achieved a statistically significant decrease in anaerobic microbiota (p< 0.05).


RESUMEN: El objetivo del presente estudio fue determinar el efecto de la irrigación subgingival de la clorhexidina 0,12 % sobre la microbiota anaeróbica total. Se tomaron muestras microbiológicas a 30 sujetos con periodontitis estadio II grado B, en sacos periodontales con una profundidad de sondaje > 4 mm. Se realizó la irrigación subgingival con 5 mL. de clorhexidina en el grupo test y con 5 mL. de agua destilada en el grupo control. 24 horas después del procedimiento se obtuvo una segunda muestra a comparar. Se detectó que la irrigación subgingival con clorhexidina al 0,12 % logra disminuir en forma estadísticamente significativa la microbiota anaeróbica total (p< 0,05).


Subject(s)
Humans , Periodontitis/epidemiology , Bacteria, Anaerobic/classification , Bacterial Infections/chemically induced , Dental Prophylaxis , Periodontitis/therapy , Bacterial Infections/microbiology , Chile , Chlorhexidine/administration & dosage , Epidemiology, Experimental , Statistical Analysis , Demographic Data , Sample Size , Therapeutic Irrigation
11.
Rev. ADM ; 76(4): 214-218, jul.-ago 2019. ilus
Article in Spanish | LILACS | ID: biblio-1023643

ABSTRACT

Introducción: El uso de agentes químicos en la superficie radicular durante la fase higiénica periodontal tiene como ventajas eliminar factores irritantes, prevenir la acumulación bacteriana y fomentar la cicatrización de la herida. El objetivo del presente estudio fue evaluar la superficie radicular de órganos dentales con periodontitis crónica avanzada, tratados mediante terapia periodontal no quirúrgica con EDTA y láser CO2. Material y métodos: Se evaluaron 40 órganos dentarios de pacientes con periodontitis crónica avanzada indicados para extracción, a los cuales se les realizó raspado y alisado radicular, con el uso de EDTA al 24%, láser CO2 a energía de 1, 1.5 y 2 Watt, para posteriormente evaluar la superficie radicular mediante un microscopio electrónico de barrido. Resultados: El tratamiento de raspado y alisado radicular mostró una superficie regular, pero con marcas de estrías con una cubierta de escombro dentinario, las muestras tratadas con EDTA al 24% muestran apertura de los túbulos dentinarios, con bordes definidos y un diámetro aparentemente amplio y los órganos dentarios tratados con láser CO2 con diferentes poderes de energía mostraron múltiples cambios en su superficie, con una apertura de túbulos dentinarios en su mayoría. Conclusión: La apertura de los túbulos dentinarios se presentó en los grupos experimentales tratados con biomodificador radicular (AU)


Introduction: The use of chemical agents in the root surface during the periodontal hygienic phase has the advantages of eliminating irritating factors, preventing bacterial accumulation and promoting wound healing. The objective of the present study was to evaluate the radicular surface of dental organs with advanced chronic periodontitis treated by non-surgical periodontal therapy with EDTA and CO2 laser. Material and methods: Forty dental organs of patients with advanced chronic periodontitis indicated for extraction were evaluated, which were performed scraping and root planing, with the use of 24% EDTA, CO2 laser with energy of 1, 1.5 and 2 Watt, to later evaluate the radicular surface by means of a scanning electron microscope. Results: The treatment of scaling and root planing showed a regular surface, but with marks of striae with a covering of dentine rubble, the samples treated with 24% EDTA show opening of the dentinal tubules, with defined edges and a seemingly wide diameter and, the dental organs treated with CO2 laser with different power powers showed multiple changes in their surface, with an opening of dentinal tubules in their majority. Conclusion: The opening of the dentinal tubules was presented in the experimental groups treated with a root biomodifier (AU)


Subject(s)
Humans , Periodontitis/therapy , Tooth Root/drug effects , Dental Scaling , Edetic Acid , In Vitro Techniques , Microscopy, Electron, Scanning , Epidemiology, Descriptive , Cross-Sectional Studies , Prospective Studies , Lasers, Gas
13.
J. appl. oral sci ; 27: e20180671, 2019. tab, graf
Article in English | LILACS, BBO | ID: biblio-1019970

ABSTRACT

Abstract Objective: To monitor early periodontal disease progression and to investigate clinical and molecular profile of inflamed sites by means of crevicular fluid and gingival biopsy analysis. Methodology: Eighty-one samples of twenty-seven periodontitis subjects and periodontally healthy individuals were collected for the study. Measurements of clinical parameters were recorded at day −15, baseline and 2 months after basic periodontal treatment aiming at monitoring early variations ofthe clinical attachment level. Saliva, crevicular fluid and gingival biopsies were harvested from clinically inflamed and non-inflamed sites from periodontal patients and from control sites of healthy patients for the assessment of IL-10, MMP-8, VEGF, RANKL, OPG and TGF-β1 protein and gene expression levels. Results: Baseline IL-10 protein levels from inflamed sites were higher in comparison to both non-inflamed and control sites (p<0.05). Higher expression of mRNA for IL-10, RANK-L, OPG, e TGF-β1 were also observed in inflamed sites at day −15 prior treatment (p<0.05). After the periodontal treatment and the resolution of inflammation, seventeen percent of evaluated sites still showed clinically detectable attachment loss without significant differences in the molecular profile. Conclusions: Clinical attachment loss is a negative event that may occur even after successful basic periodontal therapy, but it is small and limited to a small percentage of sites. Elevated inflammation markers of inflamed sites from disease patients reduced to the mean levels of those observed in healthy subjects after successful basic periodontal therapy. Significantly elevated both gene and protein levels of IL-10 in inflamed sites prior treatment confirms its modulatory role in the disease status.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Periodontal Attachment Loss/pathology , Periodontitis/therapy , Saliva/chemistry , Time Factors , Biopsy , Biomarkers/analysis , Case-Control Studies , Cytokines/analysis , Gingival Crevicular Fluid/chemistry , Statistics, Nonparametric , Matrix Metalloproteinase 8/analysis , Vascular Endothelial Growth Factor A/analysis , Osteoprotegerin/analysis , Real-Time Polymerase Chain Reaction , Gingiva/pathology
14.
Braz. oral res. (Online) ; 33: e033, 2019. tab, graf
Article in English | LILACS | ID: biblio-1011662

ABSTRACT

Abstract The aim of this study was to evaluate the effect of periodontal treatment on the salivary cytokine levels and clinical parameters of individuals with cerebral palsy (CP) with gingivitis. A non-randomized, clinical trial was conducted in individuals diagnosed with spastic CP. Thirty-eight individuals were enrolled in the study and were categorized according to gingival index scores between 0-1 or 2-3, assigned to groups G2 or G1, respectively. Periodontal treatment comprised oral hygiene instructions, conventional mechanical treatment and 0.12% chlorhexidine applied as an adjunct. Clinical parameters and saliva samples were collected at baseline and at the 15-day follow-up visit. Bleeding on probing and periodontal screening and recording were determined. Non-stimulated saliva samples were obtained, and the salivary flow rate, the osmolality and the levels of cytokines IL-1β, IL-6, IL-8, IL-10, TNF-α and IL-12p70 were evaluated by a cytometric bead array. The Wilcoxon test, the Mann-Whitney test, Spearman correlation analysis, Poisson regression analysis and an adjusted analysis were performed (α = 0.05). The groups differed significantly in periodontal clinical parameters at baseline and at follow-up. Salivary flow rate and osmolality were similar in both groups at both timepoints. However, TNF-α and IL-1β levels were higher in G1 than in G2 at baseline. Mechanical treatment resulted in improved clinical parameters for both groups. Furthermore, mechanical treatment resulted in a significant reduction in salivary IL-1β and IL-8 levels for both groups after treatment. Periodontal treatment performed in individuals with CP and gingivitis reduces the levels of TNF-α, IL-1β, IL-6 and IL-8.


Subject(s)
Humans , Male , Female , Child , Adolescent , Periodontitis/therapy , Saliva/chemistry , Biomarkers/analysis , Cerebral Palsy/complications , Gingivitis/complications , Gingivitis/rehabilitation , Osmolar Concentration , Saliva/immunology , Saliva/microbiology , Poisson Distribution , Periodontal Index , Cytokines/analysis , Interleukin-6/analysis , Tumor Necrosis Factor-alpha/analysis , Interleukin-10 , Dental Prophylaxis/methods , Interleukin-1beta/analysis , Gingivitis/microbiology
15.
J. appl. oral sci ; 27: e20180205, 2019. tab, graf
Article in English | LILACS, BBO | ID: biblio-1002408

ABSTRACT

Abstract Porphyromonas gingivalis is one of the most important Gram-negative anaerobe bacteria involved in the pathogenesis of periodontitis. P. gingivalis has an arsenal of specialized virulence factors that contribute to its pathogenicity. Among them, fimbriae play a role in the initial attachment and organization of biofilms. Different genotypes of fimA have been related to length of fimbriae and pathogenicity of the bacterium. Objectives The aim of this study was to identify 5 types of fimA genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy. Material and Methods Thirty-one patients with periodontitis harboring P. gingivalis were selected: 16 nonsmokers (NS) and 15 smokers (SM). Clinical and microbiological parameters were evaluated at baseline and 3 months after periodontal treatment, namely: plaque index, bleeding on probe, probing depth, gingival recession and clinical attachment level. The frequency of P. gingivalis and fimA genotype strains were determined by polymerase chain reaction. Results Type I fimA was detected in the majority of SM and NS at baseline, and the frequency did not diminish after 3 months of treatment. The frequency of type II genotype was higher in SM than NS at baseline. After 3 months, statistical reduction was observed only for types II and V fimA genotypes in SM. The highest association was found between types I and II at baseline for NS (37.5%) and SM (53.3%). Conclusion The most prevalent P. gingivalis fimA genotypes detected in periodontal and smoker patients were genotypes I and II. However, the presence of fimA genotype II was higher in SM. Periodontal treatment was effective in controlling periodontal disease and reducing type II and V P. gingivalis fimA.


Subject(s)
Humans , Male , Female , Adult , Aged , Periodontitis/microbiology , Periodontitis/therapy , Smoking/adverse effects , Porphyromonas gingivalis/isolation & purification , Fimbriae Proteins/isolation & purification , Periodontitis/pathology , Time Factors , DNA, Bacterial , Periodontal Index , Polymerase Chain Reaction , Porphyromonas gingivalis/genetics , Statistics, Nonparametric , Fimbriae Proteins/genetics , Genotype , Middle Aged
16.
Rev. cuba. hematol. inmunol. hemoter ; 34(3): 1-9, jul.-set. 2018. tab
Article in Spanish | LILACS, CUMED | ID: biblio-985533

ABSTRACT

Introducción: la periodontitis crónica es un proceso inflamatorio de origen bacteriano que afecta a los tejidos del periodonto y provoca la destrucción de los tejidos de soporte del diente. La terapia celular con células mononucleares autólogas constituye una nueva opción terapéutica para lograr la regeneración ósea. Objetivo: evaluar la efectividad del tratamiento con células mononucleares autólogas implantadas en defectos óseos provocados por la periodontitis crónica. Método: estudio cuasiexperimental que se realizó en la Clínica Provincial Docente Antonio Briones Montoto de Pinar del Río, en el periodo comprendido entre enero de 2012 hasta agosto de 2015. A los nueve pacientes del grupo de estudio, se le realizó la perfusión de células mononucleares siete días después de ser intervenidos quirúrgicamente (colgajo periodontal). La movilización a sangre periférica de células mononucleares autólogas se realizó con factor estimulante del crecimiento granulocítico Leukocim (FEC-G). Variables del estudio: dientes afectados, presencia de sangrado al sondeo, bolsas periodontales, movilidad dentaria, pérdida de inserción y evidencia radiográfica. Resultados: posterior a la terapia celular se constató que las encías presentaron características de normalidad a los 7 días de implantados, a los 12 meses se observó hueso de neoformación y aumento de la densidad ósea. Conclusiones: la terapia mostró ser un método factible, simple y seguro en la reparación de defectos óseos provocados por la enfermedad, evidenciando mejoría de los parámetros clínicos y radiográficos(AU)


Introduction: Periodontitis is an inflammatory process of bacterial origin that affects the tissues of the periodontium and causes the destruction of the tissues supporting the tooth. Cell therapy could be an effective therapeutic option to achieve bone regeneration. Objective: To evaluate the effectiveness of treatment with implanted autologous mononuclear cells in bone defects caused by periodontal disease. Methods: A quasiexperimental study was carried out in the Provincial Teaching Clinic Antonio Briones Montoto, Pinar del Río, in the period from January 2012 to August 2015. The nine patients in the study group underwent perfusion of mononuclear cells seven days after surgery (periodontal flap). The mobilization to peripheral blood of autologous mononuclear cells was made with granulocytic leukocyte growth stimulating factor (FEC-G). Study variables: affected teeth, presence of bleeding on probing, periodontal pockets, tooth mobility, loss of insertion and radiographic evidence. Results: After the cell therapy, it was found that the gums showed normality characteristics after 7 days of implantation, after 12 months neoformation bone and increase in bone density was observed. Conclusions: The therapy showed to be a feasible, simple and safe method in the repair of bone defects caused by the disease, evidencing improvement of the clinical and radiographic parameters(AU)


Subject(s)
Humans , Periodontitis/drug therapy , Periodontitis/therapy , Alveolar Bone Loss/therapy , Cell- and Tissue-Based Therapy/methods , Leukocytes, Mononuclear , Non-Randomized Controlled Trials as Topic , Prolotherapy/methods
17.
J. oral res. (Impresa) ; 7(6): 263-270, ago. 1, 2018.
Article in English | LILACS | ID: biblio-1120993

ABSTRACT

Abstract: oral health is an integral part of an individual's general health, interfering with all dimensions of life: functional, aesthetic, psychological, social, physical, nutritional, and even psychosocial. hence oral health is directly related to quality of life. periodontitis is one of the most prevalent oral diseases and one of the major causes of tooth loss, impacting negatively on self-reported individuals' quality of life. periodontal maintenance therapy aims to effectively minimize the recurrence of periodontal disease, as well as the incidence of tooth loss. in periodontal literature, studies associated with quality of life indicators, presented in the form of questionnaires aimed at measuring the impact of periodontitis and tooth loss on self-reported individual's quality of life, highlight the "oral impacts on daily performance" (OIDP) and "oral health impact profile" (OHIP). as such, this study presents a critical review of the literature and describes the impact of periodontal disease and tooth loss on the quality of life of patients undergoing periodontal maintenance therapy.


Subject(s)
Humans , Periodontitis/therapy , Quality of Life , Oral Health , Tooth Loss/psychology , Periodontal Diseases , Patient Compliance
18.
Rev. inf. cient ; 97(supl.2): 439-447, 2018.
Article in Spanish | LILACS, CUMED | ID: biblio-999316

ABSTRACT

Se realizó un estudio cuasi experimental, longitudinal y prospectivo, con el objetivo de evaluar el tratamiento de los defectos óseos complejos con coralina y membrana de colágeno. El universo estuvo constituido por 18 pacientes de ambos sexos entre 25 y 54 años de edad atendidos en la Clínica "Lidia Doce Sánchez" de Guantánamo desde 2014 hasta 2017. Los pacientes se distribuyeron según grupos de edades, fueron evaluados luego del año de ser intervenidos. Se evidenció mayoritariamente el grupo de edades de 35-44 años, la ausencia de bolsas periodontales, la movilidad dentaria grado 0. La osteointegración grado III y una evaluación buena del tratamiento con coralina y membrana de colágeno en defectos óseos complejos, coincidieron en primacía(AU)


A quasi-experimental, longitudinal and prospective study was carried out, with the aim of evaluating the treatment of complex bone defects with coralina and collagen membrane. The universe consisted of 18 patients of both sexes between 25 and 54 years of age attended in the Clinic "Lidia Doce Sánchez" of Guantanamo from 2014 to 2017. The patients were distributed according to age groups, were evaluated after the being operated. The age group of 35-44 years, the absence of periodontal pockets, the grade 0 tooth mobility were evidenced. The osseo integration grade III and a good evaluation of the treatment with coralina and collagen membrane in complex bone defects coincided in primacy(AU)


Subject(s)
Humans , Adult , Periodontitis/diagnosis , Periodontitis/therapy , Biocompatible Materials/therapeutic use , Collagen/therapeutic use , Prospective Studies , Longitudinal Studies , Non-Randomized Controlled Trials as Topic
19.
J. appl. oral sci ; 26: e20170266, 2018. tab, graf
Article in English | LILACS, BBO | ID: biblio-954507

ABSTRACT

Abstract Objective In this study, we aimed to histologically and immunologically evaluate the effect of diode laser treatment when applied adjunctive to scaling and root planing (SRP) in an experimental periodontitis model. Materials and methods We used Wistar-Albino rats (n=60) with average weight of 230 g. Experimental periodontitis was induced by ligature at the right and left first mandibular molar teeth in all rats. After 11 days, the ligature was removed and rats were divided into two groups. The control group (n=30) received only SRP treatment, while the laser group (n=30) received a diode laser (GaAlAs, 810 nm, 1 W, 10 J, 20 s) treatment adjunctive to SRP. Ten rats in each group were sacrificed after 7, 15, and 30 days. Histopathological examination was performed in the left mandible of rats. Myeloperoxidase (MPO) was evaluated by western blot in the gingival specimens from the right mandible. Results MPO levels in the laser group were statistically significantly lower compared with the control group (p≤0.05). There was no statistically significance at any time between MPO levels in the control group (p>0.05). MPO levels in the laser group at the 7th day were statistically significantly higher compared to the 15th (p≤0.05) and the 30th day (p≤0.05). Inflammatory cell infiltration decreased over time in both groups and was statistically significantly lower in the laser group than in the control group at all times (p≤0.01). Conclusions Within the limits of this study, we suggest that diode laser application is an adjunctive treatment because it reduced inflammation and MPO when applied in addition to SRP. On the other hand, more studies are needed for the assessment of the effects of diode laser application to periodontal tissues.


Subject(s)
Animals , Periodontitis/pathology , Periodontitis/therapy , Dental Scaling/methods , Peroxidase/analysis , Low-Level Light Therapy/methods , Lasers, Semiconductor/therapeutic use , Periodontitis , Time Factors , Random Allocation , Blotting, Western , Reproducibility of Results , Treatment Outcome , Rats, Wistar , Combined Modality Therapy , Disease Models, Animal , Ligation
20.
J. appl. oral sci ; 25(4): 387-395, July-Aug. 2017. tab, graf
Article in English | LILACS, BBO | ID: biblio-893639

ABSTRACT

Abstract Low intensity laser can be used as a promising alternative in the treatment of periodontal disease. Objective The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvastatin-modified rats. Material and Methods A total of 180 rats were evenly divided into two groups: Veh - receiving oral administration of polyethylene glycol (vehicle); S - receiving oral administration of Simvastatin. Periodontal disease was induced in both groups at the first mandibular molar. After seven days, the ligature was removed and the animals were divided into subgroups according to the following local treatments: NT - no treatment; SRP - scaling and root planing and irrigation with saline solution; and LLLT ¬- SRP and laser irradiation (660 nm; 0.03 W; 4 J). Ten animals in each subgroup/local treatment were euthanized at 7, 15 and 30 days. Samples of gingival tissue were processed to analyze the tissue oxidative damage and radiographic analysis. Levels of oxidative stress were analyzed by the expressions of Tripeptideglutathione (TG), Malondialdehyde (MDA) and Carbonylated Proteins (CP). Results The animals in S group had higher levels of TG and lower levels of MDA and CP compared with Veh group (p<0.05). Radiographically, in the intragroup analysis Veh and S, LLLT showed lower bone loss (BL) compared with NT and SRP, in all experimental periods (p<0.01). In addition, a lower BL was observed for the animals of Veh group treated with LLLT compared with treatment SRP in the S group, in all experimental periods. Conclusion Within the limits of this study, we can conclude that LLLT was effective as adjuvant treatment for SRP protecting against the occurrence of oxidative tissue damages as well as for reducing alveolar bone loss in experimentally induced periodontitis simvastatin-modified rats.


Subject(s)
Animals , Male , Periodontitis/therapy , Dental Scaling/methods , Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology , Simvastatin/pharmacology , Low-Level Light Therapy/methods , Lasers, Semiconductor/therapeutic use , Periodontitis/diagnostic imaging , Reference Values , Time Factors , Random Allocation , Reproducibility of Results , Treatment Outcome , Rats, Wistar , Radiotherapy, Adjuvant , Protein Carbonylation , Gingiva/drug effects , Gingiva/chemistry , Glutathione/analysis , Malondialdehyde/analysis , Mandible/diagnostic imaging
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