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1.
Rev. Ciênc. Plur ; 7(2): 287-298, maio 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1284583

ABSTRACT

Introdução: Devido à crescente demanda estética, a odontologia restauradora se renova na intenção de alcançar melhores resultados na harmonia do sorriso. Entretanto, a atenção deve voltar-se também aos tecidos periodontais, visto que há uma integração entre material restaurador e os tecidos. Objetivo:Descrever e discutir as etapas clínicas para a confecção de laminados cerâmicos, atentando-se a preparos minimamente invasivos, contorno cervical e fatores que podem intervir na longevidade do procedimento.Relato de caso:Paciente do sexo masculino, 28 anos de idade, compareceu a Associação Brasileira de Odontologia, seção de Alagoas, relatando insatisfação em relação ao tamanho dos seus dentes. Os arcos superior e inferior foram moldados para a obtenção dos modelos de estudo e enceramento diagnóstico. Ao início do tratamento foi orientado ao paciente clareamento dental pela técnica combinada. O preparo dos dentes foi guiado por uma matriz de silicone, sendo estes uniformes e conservadores, seguido de moldagem, fase laboratorial e cimentação final. Finalizado o caso foi realizado o ajuste oclusal solicitando ao paciente que realizasse movimentos de lateralidade e protrusão. Conclusões:A técnica do preparo influência na longevidade dos laminados cerâmicos, por relacioanar-se à adesão e a saúde periodontal. O preparo deve ser mínino e limitado ao esmalte dental sempre que possível, determinando assim um maior e melhor prognóstico (AU).


Introduction:Due to the growing aesthetic demand, restorative dentistry is renewed to achieve better results in smile harmony. However, attention should also be turned to periodontal tissues since there is an integration between restorative material and tissues. Objective:To describe and discuss the clinical steps for the manufacture of laminate veneers, paying attention to minimally invasive preparations, cervical contour, and factors that can intervene in the procedure's longevity. Case report:A 28-year-old male patient attended the Brazilian Dental Association, the Alagoas section, reporting dissatisfaction with his teeth' size. The upper and lower arches were molded to obtain the study and diagnostic waxing models. At the beginning of treatment, the patient was instructed by the combined technique. After the case, the occlusal adjustment was performed, asking the patient to perform laterality and protrusion movements. Conclusions:The preparation technique influences the longevity of laminate veneers due to adherence and periodontal health. The preparation should be minimal and limited to dental enamel whenever possible, thus determining a higher and better prognosis (AU).


Introducción: Debido a la creciente demanda estética, la odontología restauradora se renueva para lograr mejores resultados en la armonía de la sonrisa. Sin embargo, también se debe prestar atención a los tejidos periodontales ya que existe una integraciónentre el material restaurador y los tejidos.Objetivo: Describir y discutir los pasos clínicos para la confección de carillas laminares, prestando atención a las preparaciones mínimamente invasivas, al contorno cervical y a los factores que pueden intervenir en la longevidad del procedimiento.Reporte del caso: Un paciente masculino de 28 años asistió a la Asociación Dental Brasileña, sección de Alagoas, reportando insatisfacción con el tamaño de sus dientes. Los arcos superior e inferior fueron moldeados para obtener los modelos de depilación de estudio y diagnóstico. Al comienzo del tratamiento, el paciente fue instruido por la técnica combinada. La preparación de los dientes fue guiada por una matriz de silicona, siendo estas uniformes y conservadoras, seguidas de moldeo, fase de laboratorio y cementación final. Después del caso, se realizó el ajuste oclusal, pidiendo al paciente que realizara movimientos de lateralidad y protuberancia. Conclusiones: La técnica de preparación influye en la longevidad de los laminados cerámicos, debido a la adherencia y la salud periodontal. La preparación debe ser mínima y limitada al esmalte dental siempre que sea posible, determinando así un pronóstico más alto y mejor (AU).


Subject(s)
Humans , Male , Adult , Tooth Bleaching , Periodontium , Tooth Preparation, Prosthodontic/instrumentation , Dental Veneers , Brazil/epidemiology , Radiography, Dental/instrumentation , Ceramics , Occlusal Adjustment , Dental Enamel , Research Report , Longevity , Models, Anatomic
2.
Article in English | LILACS, BBO | ID: biblio-1250459

ABSTRACT

Abstract Objective: To measure the level of immunoglobulin G (IgG) in the gingival crevicular fluid (GCF). Material and Methods: A total of 158 patients aged >45 years were examined for periodontitis and interviewed regarding their menopausal status. The non-menopause group entailed female patients with periodontitis without menopause (n=23). The menopause group included females who stopped menstruating since >1 year, had a pocket depth of 4-5 mm, and did not have other systemic conditions (n=40). Samples were selected based on periodontal and menopausal status. In total, 63 samples of GCF were collected from the participants and tested using an enzyme-linked immunosorbent assay kit for IgG. Results: The median level of IgG in the menopause group was 39.50 (g/mL, whereas that of the non-menopause group was 41.08 (g/mL. There was a positive correlation between the plaque index and IgG level in both groups. In contrast, there was a negative correlation between age and IgG level. However, there was no correlation between plaque index and age regarding the IgG level in both groups (p>0.05). Conclusion: The IgG levels in the menopause group were lower than those in the non-menopause group. As such, menopausal females should take great care of their overall health, including the periodontium.


Subject(s)
Humans , Female , Adult , Middle Aged , Periodontal Diseases/pathology , Periodontitis/pathology , Periodontium , Immunoglobulin G , Menopause , Cross-Sectional Studies/methods , Gingival Crevicular Fluid , Statistics, Nonparametric , Indonesia/epidemiology
3.
Rev. Fundac. Juan Jose Carraro ; 24(44): 20-25, 2021.
Article in Spanish | LILACS | ID: biblio-1223204

ABSTRACT

La enfermedad periodontal (EP) es una patología que afecta principalmente los tejidos que rodean a la pieza dentaria (PD) y se caracteriza, en la mayoría de los casos, por una exposición bacteriana que favorece una respuesta destructiva e inflamatoria del huésped, que conduce a la pérdida de inserción periodontal de la PD, provocando una marcada reabsorción ósea y la posible pérdida de las PD. El diagnóstico de EP implica evaluaciones clínicas y radiográficas, en la actualidad se están realizando diversas investigaciones para evaluar posibles compuestos en los fluidos orales a través de lo cual puede ser posible evaluar la presencia y gravedad de estas enfermedades, como así también el riesgo en los pacientes. Hay evidencias de la interacción de macromoléculas salivales, como las mucinas, con microorganismos específicos. De esta manera las mucinas, junto con otros productos de la saliva, ayudan a modular tanto el número como el tipo de proliferación de ciertos organismos y provocar la disminución de otros. La revisión de la literatura actual concluye que las mucinas salivales pueden servir como un parámetro bioquímico de la inflamación del periodonto (AU)


Periodontal disease (PD) is a pathology that mainly affects the tissues surrounding the tooth (PD) and is characterized, in most cases, by a bacterial exposure that favors a destructive and inflammatory response of the host, which leads to the loss of periodontal insertion of the PD, causing a marked bone resorption and the possible loss of the PD. The diagnosis of PD involves clinical and radiographic evaluations, at present several investigations are being carried out to evaluate possible compounds in oral fluids through which it may be possible to evaluate the presence and severity of these diseases, as well as the risk in patients. There is evidence of the interaction of salivary macromolecules, such as mucins, with specific microorganisms. In this way, mucins, together with other saliva products, help modulate both the number and type of proliferation of certain organisms and cause the decrease of others. The review of the current literature concludes that salivary mucins can serve as a biochemical parameter of inflammation of the periodontium (AU)


Subject(s)
Humans , Periodontal Diseases , Biomarkers , Mucins/physiology , Saliva/immunology , Salivary Proteins and Peptides/physiology , Periodontium/physiopathology , Alveolar Bone Loss/etiology , Inflammation Mediators/physiology
4.
Rev. Fundac. Juan Jose Carraro ; 24(44): 48-53, 2021. ilus, tab, graf
Article in Spanish | LILACS | ID: biblio-1223615

ABSTRACT

La odontología estética no es una disciplina especial o área de la odontología en sí misma, pero con consideraciones funcionales y biológicas, representa uno de los objetivos de las intervenciones de tratamiento dental, que abarca todas las áreas de especialidad, desde la odontología preventiva y restaurativa hasta la prostodoncia, ortodoncia, periodoncia, como, así como la cirugía oral y maxilofacial. El cénit gingival es un importante componente de la sonrisa y su estudio sigue siendo muy relevante en la odontoestética internacional. En el presente trabajo se determinaron distancias del cenit al eje longitudinal y se correlacionaron con otros parámetros gingivales, se establecieron diferencias en las alturas de las papilas interdentales y se correlacionaron los datos métricos de las piezas dentarias anteriores de la población estudiada y los datos conocidos con el fin de obtener datos estadísticos relevantes. Los datos mesurables fueron obtenidos de pacientes de ambos sexos, (18 ­ 25) años, con piezas dentarias del grupo anterior y superior a saber: incisivos centrales, incisivos laterales y caninos superiores, normalmente implantados, libres de lesiones o restaruración, ausencia de enfermedad gingivoperiodontal y sin tratamientos ortodoncicos. El trabajo observacional, descriptivo y tranversal arrojó resultados basados en la estadística preponderante. Provee dimensiones y proporciones de dientes maxilares que pueden adaptarse a pacientes individuales en relación con parámetros establecidos en la odontoestética. Estos datos pueden ser pautas útiles para el diagnóstico y la planificación del tratamiento (especialmente cirugía periodontal) en la dentición maxilar (AU)


A esthetic dentistry is not a special discipline or area of dentistry itself, but with functional and biological considerations, it represents one of the objectives of dental treatment interventions, which covers all areas of specialty, from preventive and restorative dentistry up to prosthodontics, orthodontics, periodontics, as well as oral and maxillofacial surgery. The gingival cenith is an important component of the smile and its study remains very relevant in international dentistry. In this work, distances from the cenith to the longitudinal axis were determined and correlated with other gingival parameters, differences in the heights of the interdental papillae were established and the metric data of the anterior teeth of the studied population were correlated and the known data with in order to obtain relevant statistical data. The measurable data were obtained from patients of both sexes, (18 - 25) years, with teeth of the anterior and superior group, namely: central incisors, lateral incisors and upper canines, normally implanted, free of lesions or restoration, absence of disease gingivoperiodontal and without orthodontic treatments. The observational, descriptive and transverse work produced results based on the preponderant statistics. It provides dimensions and proportions of maxillary teeth that can be adapted to individual patients in relation to parameters established in odontoesthetics. These data can be useful guidelines for diagnosis and treatment planning (especially periodontal surgery) in the maxillary dentition (AU)


Subject(s)
Humans , Male , Female , Adolescent , Adult , Smiling , Esthetics, Dental , Gingiva/anatomy & histology , Periodontium/anatomy & histology , Epidemiology, Descriptive , Cross-Sectional Studies , Data Interpretation, Statistical , Cuspid , Dental Papilla/anatomy & histology , Observational Study , Incisor
5.
Article in English | WPRIM | ID: wpr-888697

ABSTRACT

Nowadays, orthodontic treatment has become increasingly popular. However, the biological mechanisms of orthodontic tooth movement (OTM) have not been fully elucidated. We were aiming to summarize the evidences regarding the mechanisms of OTM. Firstly, we introduced the research models as a basis for further discussion of mechanisms. Secondly, we proposed a new hypothesis regarding the primary roles of periodontal ligament cells (PDLCs) and osteocytes involved in OTM mechanisms and summarized the biomechanical and biological responses of the periodontium in OTM through four steps, basically in OTM temporal sequences, as follows: (1) Extracellular mechanobiology of periodontium: biological, mechanical, and material changes of acellular components in periodontium under orthodontic forces were introduced. (2) Cell strain: the sensing, transduction, and regulation of mechanical stimuli in PDLCs and osteocytes. (3) Cell activation and differentiation: the activation and differentiation mechanisms of osteoblast and osteoclast, the force-induced sterile inflammation, and the communication networks consisting of sensors and effectors. (4) Tissue remodeling: the remodeling of bone and periodontal ligament (PDL) in the compression side and tension side responding to mechanical stimuli and root resorption. Lastly, we talked about the clinical implications of the updated OTM mechanisms, regarding optimal orthodontic force (OOF), acceleration of OTM, and prevention of root resorption.


Subject(s)
Humans , Osteoblasts , Osteoclasts , Periodontal Ligament , Periodontium , Root Resorption , Tooth Movement Techniques
6.
Article in English | WPRIM | ID: wpr-922470

ABSTRACT

Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, have hampered their clinical application. These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system. However, the potential function of MSC-exos produced by 3D culture (3D-exos) in periodontitis remains elusive. This study showed that compared with MSC-exos generated via 2D culture (2D-exos), 3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17 (Th17) cell/Treg balance in inflamed periodontal tissues. Mechanistically, 3D-exos exhibited greater enrichment of miR-1246, which can suppress the expression of Nfat5, a key factor that mediates Th17 cell polarization in a sequence-dependent manner. Furthermore, we found that recovery of the Th17 cell/Treg balance in the inflamed periodontium by the local injection of 3D-exos attenuated experimental colitis. Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium.


Subject(s)
Colitis , Exosomes , Humans , Periodontitis/therapy , Periodontium , T-Lymphocytes, Regulatory , Th17 Cells
7.
Article in English | WPRIM | ID: wpr-887757

ABSTRACT

OBJECTIVES@#The safety of root canal filling with 200 °C hot gutta-percha was investigated to study the effect of continuous wave technique combined with high-temperature injectable gutta-percha condensation technique on the surface temperature of periodontal tissue.@*METHODS@#CT technique and Mimics, Geomagic, and Solidworks software were utilized to build the entity models of alveolar bone, dentin and root canal, periodontal ligament, and blood flow, respectively, which were then assembled in Solidworks into a finite element model of tooth with blood flow. By utilizing ABAQUS collaborative simulation platform, fluid-structure coupling was analyzed on the whole process of root canal filling. Consequently, the surface temperature of the periodontal tissue was obtained.@*RESULTS@#In the absence of blood flow, the temperature of the periodontal ligament surface reached 50.048 ℃ during root canal filling with 200 ℃ gutta-percha. Considering blood flow, the temperature of periodontal ligament surface was 39.570 ℃.@*CONCLUSIONS@#The temperature of the periodontal ligament surface increased when the continuous wave root canal was filled with 200 ℃ gutta-percha, and the periodontal tissue was not damaged.


Subject(s)
Dental Pulp Cavity , Finite Element Analysis , Gutta-Percha , Hot Temperature , Humans , Periodontium , Root Canal Filling Materials , Root Canal Obturation , Temperature
8.
Article in English | WPRIM | ID: wpr-878455

ABSTRACT

Eosinophilic granuloma, a rare disease, has various clinical manifestations and no specific X-rays features and is thus easily misdiagnosed. This paper reports a case of multifocal eosinophilic granuloma of jaw with long-term follow-up. The patient initially presented with periodontal tissue destruction.The diagnosis, treatment and prognosis of multifocal eosinophilic granuloma of jaw were discussed in combination with the literature to alert this disease in clinical practice.


Subject(s)
Diagnosis, Differential , Eosinophilic Granuloma/diagnostic imaging , Humans , Jaw , Periodontium , Radiography
9.
J. appl. oral sci ; 28: e20190766, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1134790

ABSTRACT

Abstract Objective To compare two corticotomy surgical protocols in rats to verify whether they alter conventional orthodontic movement. Methodology Sixty Wistar rats were divided into three groups - orthodontic movement (CG), orthodontic movement and corticotomy (G1) and orthodontic movement with corticotomy and decortication (G2) - and euthanized after 7 and 14 days. Tooth movement (mm), bone volume fraction and bone volume ratio to total volume (BV/TV), and bone mineral density (BMD) were evaluated by micro-CT. The total amount of bone was measured in square millimeters and expressed as the percentage of bone area in the histomorphometry. The number of positive TRAP cells and RANK/RANKL/OPG interaction were also investigated. Results Day 14 showed a statistically significant difference in orthodontic tooth movement in CG compared with G1 (7.52 mm; p=0.009) and G2 (7.36 mm; p=0.016). A micro-CT analysis revealed a difference between CG, G1 and G2 regarding BV/TV, with G1 and G2 presenting a lower BV/TV ratio at 14 days (0.77 and 0.73 respectively); we found no statistically significant differences regarding BMD. There was a difference in the total amount of bone in the CG group between 7 and 14 days. At 14 days, CG presented a significantly higher bone percentage than G1 and G2. Regarding TRAP, G2 had more positive cells at 7 and 14 days compared with CG and G1. Conclusion Corticotomy accelerates orthodontic movement. Decortication does not improve corticotomy efficiency.


Subject(s)
Animals , Rats , Tooth Movement Techniques , Alveolar Process , Periodontium , Rats, Wistar , X-Ray Microtomography
10.
Odontol. vital ; (31): 45-52, jul.-dic. 2019.
Article in Spanish | LILACS | ID: biblio-1091427

ABSTRACT

Resumen El objetivo primordial en la terapia de la regeneración ósea guiada viene a ser la restauración de los componentes del periodonto. La racionalidad de esta terapia es dar la preferencia a tipos celulares específicos para repoblar la zona de la herida a formar un nuevo aparato de inserción. De manera clínica esto se logra al colocar una barrera física sobre el defecto periodontal, dejando de lado los tejidos gingivales en las etapas tempranas de reparación. Este trabajo analiza la evidencia científica que existe de los resultados alcanzados mediante la ROG, los factores que influyen con el tipo de materiales utilizados, sus indicaciones, sus componentes, sus contraindicaciones, los mecanismos de evaluación, así como las propiedades de distintas barreras utilizadas desde un punto de vista del biomaterial.


Abstract The primary goal in the therapy of guided bone regeneration is to restore the components of the periodontium. The rationale of this therapy is to give preference to specific cell types to repopulate the wounded area to form a new insertion apparatus. Clinically this is achieved by placing a physical barrier on the periodontal defect, leaving the gingival tissues aside in the early stages of repair. This work analyzes the scientific evidence that exists about the results achieved by the ROG, the factors that influence the type of materials used, their indications, their components, their contraindications, the evaluation mechanisms, as well as the properties of different barriers used since a biomaterial point of view.


Subject(s)
Bone Regeneration , Periodontium/physiopathology , Alveolar Bone Loss
11.
Prensa méd. argent ; 105(9 especial): 571-575, oct 2019. fig, tab
Article in English | LILACS, BINACIS | ID: biblio-1046618

ABSTRACT

The mobility of teeth in terms of periotestometry and hydration of periodontal tissues in terms of bioimpedance spectrometry were studied in healthy volunteers without dental and concomitant somatic diseases. It was found that teeth of these subjects have both low and pathological mobility. It was also revealed as increased hydration (edema), indicating the presence of inflammation, and reduced hydration, indicating atrophic processes in periodontal tissues. A comparison of the data of periotestometry and bioimpedance spectrometry showed that the indicators of mobility of the teeth and hydration of the periodontal tissues reflect different characteristics of the functional state of dentoalveolar system, and can be used as complementary in the diagnostic studies.


Subject(s)
Periodontal Diseases/diagnosis , Spectrum Analysis , Tooth Mobility/diagnosis , Periodontium/anatomy & histology , Organism Hydration Status
12.
Int. j. odontostomatol. (Print) ; 13(1): 23-30, mar. 2019. tab, graf
Article in English | LILACS | ID: biblio-990060

ABSTRACT

ABSTRACT: Periodontium can submit changes that lead to loss of integrity, such as periodontal disease, immune disorders or traumatic brushing. One of the most common consequences resulting from these events is the apical migration of gingival marginal tissue. Among biomaterials used for periodontal tissue regeneration, fibrin matrices have received significant attention to correct gingival recessions. Five oral mucosa biopsies were extracted, fibroblasts were in vitro cultured and frozen in liquid nitrogen. Three 10 mL glass sterile tubes were filled with patient blood and centrifuged immediately; clots were extracted and compressed to obtain L-PRF membranes. Autologous oral mucosa fibroblasts were added to the membranes and surgical procedures were performed in five patients. L-PRF fibrin network pore size was too small to allow human fibroblasts penetration but they were firmly attached to membrane surface. Gingival fibroblasts from fresh cell culture and recently thawed were used to attach on the L-PRF membranes. It was possible to establish a protocol for blood collection, centrifugation, fibrin clot compression, fibroblast adhesion to the membrane surface and patient application in a relatively short time (1 hour-1 hour and 30 minutes). Two patients expressed pain symptoms and the other ones presented light swelling without pain. In the first week, adjacent tissue showed few inflammation signs. Research efforts are being conducted to develop more conservative surgical techniques and new biomaterials that can promote cellular proliferation. Because of its properties, L-PRF membranes represent a tempting alternative. A combined technique to treat adjacent recession defects with L-PRF membranes and autologous oral mucosa fibroblasts in a coronal displaced flap did not show initial advantage compared with a gold standard surgery that includes an autologous soft tissue graft. Nevertheless, it could be an alternative for clinical application as a new functional cell biomaterial. More clinical evidence is needed.


RESUMEN: El periodonto puede presentar cambios que conducen a la pérdida de integridad, como la enfermedad periodontal, los trastornos inmunes o el cepillado traumático. Una de las consecuencias más comunes que resultan de estos eventos es la migración apical del tejido marginal gingival. Entre los biomateriales utilizados para la regeneración del tejido periodontal, las matrices de fibrina han recibido una atención significativa para corregir las recesiones gingivales. Se extrajeron cinco biopsias de mucosa oral, los fibroblastos se cultivaron in vitro y se congelaron en nitrógeno líquido. Tres tubos de vidrio estériles de 10 ml se llenaron con sangre del paciente y se centrifugaron inmediatamente. Los coágulos fueron extraídos y comprimidos para obtener membranas de L-PRF. Se agregaron fibroblastos autólogos de mucosa oral a las membranas y se realizaron procedimientos quirúrgicos en cinco pacientes. El tamaño de poro de la red de fibrina L-PRF era demasiado pequeño para permitir la penetración de los fibroblastos humanos, pero estaban firmemente unidos a la superficie de la membrana. Se usaron fibroblastos gingivales de cultivos de células frescas y recientemente descongelados para unirlos a las membranas L-PRF. Fue posible establecer un protocolo para la extracción de sangre, centrifugación, compresión de coágulos de fibrina, adhesión de fibroblastos a la superficie de la membrana y aplicación al paciente en un tiempo relativamente corto (1 hora, 1 hora y 30 minutos). Dos pacientes expresaron síntomas de dolor y los otros presentaron hinchazón leve sin dolor. En la primera semana, el tejido adyacente mostró pocos signos de inflamación. Se están realizando esfuerzos de investigación para desarrollar técnicas quirúrgicas más conservadoras y nuevos biomateriales que puedan promover la proliferación celular. Debido a sus propiedades, las membranas L-PRF representan una alternativa tentadora. Una técnica combinada para tratar los defectos de recesión adyacentes con membranas de L-PRF y fibroblastos de mucosa oral autóloga en un colgajo coronal desplazado no mostró una ventaja inicial en comparación con una cirugía estándar que incluye un injerto de tejido blando autólogo. Sin embargo, podría ser una alternativa para la aplicación clínica como un nuevo biomaterial de células funcionales. Se necesita más evidencia clínica.


Subject(s)
Humans , Platelet-Rich Fibrin , Gingiva/transplantation , Gingival Recession/surgery , Transplantation, Autologous , Wound Healing/physiology , Biocompatible Materials , Biopsy , In Vitro Techniques , Periodontium , Guided Tissue Regeneration, Periodontal , Fibroblasts , Gingiva/cytology , Leukocytes
13.
Braz. dent. j ; 30(2): 77-95, Mar.-Apr. 2019. tab, graf
Article in English | LILACS, BNUY, BNUY-Odon | ID: biblio-1001438

ABSTRACT

Abstract The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O'Malley's modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods.


Resumo O objetivo da presente Scoping review foi investigar as possibilidades clínicas atuais e futuras das terapias regenerativas e sua capacidade de regenerar tecido ósseo, periodontal e polpar em humanos com confirmação histológica da natureza do tecido formado. Uma busca eletrônica foi realizada utilizando uma combinação entre as palavras-chave e termos MeSH nos bancos de dados PubMed, Scopus, ISI-web of Science e Cochrane library até janeiro de 2016. Dois revisores realizaram de forma independente o julgamento dos documentos. Os estudos selecionados foram lidos seguindo os critérios de inclusão predeterminados. Os estudos incluídos foram avaliados de acordo com a estrutura modificada de Arksey e O'Malley. Dos 1349 artigos, 168 preencheram os critérios de inclusão. Várias células caracterizadas e não caracterizadas promoveram regeneração óssea utilizada em terapias celulares, demonstrando ganho ósseo em quantidade e qualidade, de forma rápida para regeneração óssea e periodontal. Os scaffolds sintéticos e naturais apresentaram boa manutenção celular, no entanto o poliglicol-polilácido apresentou uma reabsorção rápida e, consequentemente, pequeno ganho ósseo. A terapia mediada por fatores de crescimento foi capaz de regenerar tecido ósseo e todas as características de um tecido periodontal. Dentes submetidos à revascularização apresentaram aumento do comprimento e largura do canal radicular. No entanto, os tecidos formados não foram capazes de depositar dentina, caracterizando um tecido reparado. Tanto o PRP quanto o PRF parecem apresentar benefícios quando aplicados em terapias regenerativas sendo um bom scaffold natural. Portanto, a maioria dos estudos que aplicaram terapias regenerativas forneceram resultados promissores sendo possível regenerar tecido ósseo e periodontal com confirmação histológica. No entanto, não foi observada regeneração de polpa dental. Estes resultados devem ser interpretados com cautela.


Subject(s)
Root Canal Therapy , Dental Pulp , Bone Regeneration , Periodontium , Dentin
14.
Braz. dent. sci ; 22(2): 155-162, 2019. tab
Article in English | LILACS, BBO | ID: biblio-996296

ABSTRACT

Objective: To systematically review the data and results of case reports of autosomal recessive syndromes associated with periodontitis. Material and Methods: An internet search using Google and PubMed search engine and keywords- autosomal recessive, periodontitis, syndromes, periodontium and gingiva was carried out. Full-text articles in the English language of all the case reports and reviews that were published in journals from the year 1966 to 2016 were obtained and evaluated and presented in tabular form. Abstracts and articles published in other languages were not included in the review. Results: The data available from the clinical trials were analyzed and presented under broad headings of, systemic features, dental features, periodontal features and laboratory findings presented in tabular form. Conclusion: Many autosomal recessive syndromes with dental component also present with changes or alteration in the periodontium thus stressing the fact that thorough periodontal examination is important during the medical evaluation of patients with syndromes (AU)


Objetivo: Analisar sistematicamente os dados e resultados de relatos de caso de síndromes autossômicas recessivas associadas à periodontite. Material e Métodos: realizou-se uma pesquisa na internet usando os sites Google e PubMed com as palavras-chave: autossômica recessiva, periodontite, síndromes, periodonto e gengiva. Os critérios de inclusão foram restritos aos artigos em texto completo em língua inglesa, relatos de casos e revisões publicados em periódicos de 1966 a 2016. Resumos e artigos publicados em outras línguas não foram incluídos na revisão. Resultados: Os dados extraídos de cada estudo foram agrupados da seguinte forma: as síndromes associadas a características sistêmicas, aos achados dentários e aos achados periodontais, apresentados no formato de tabelas. Conclusões: Diversas síndromes autossômicas recessivas que apresentam alterações dentárias também podem apresentar alterações no periodonto, ressaltando assim, o fato de que o exame periodontal completo é importante durante a avaliação médica de pacientes com síndromes (AU)


Subject(s)
Periodontitis , Syndrome , Periodontium , Gingiva , Job Syndrome
15.
Rev. Salusvita (Online) ; 38(3): 755-766, 2019.
Article in Portuguese | LILACS | ID: biblio-1052048

ABSTRACT

Introdução: Na odontologia, a oclusão é a relação dos dentes superiores situados na maxila com os dentes inferiores situados na mandíbula quando se encontram em atividade normal e fisiológica, sem ocasionar desconfortos e dores para o paciente durante a mastigação. De forma contrária, temos uma alteração patológica ou adaptativa que pode lesionar o periodonto devido a forças excessivas, estas podem resultar no trauma oclusal. Objetivos: Sintetizar informações de bases científicas que abordem o trauma oclusal em busca de evidenciar a importância do conhecimento sobre a sua etiologia, diagnóstico e possíveis tratamentos para essa patologia. Métodos: Foi realizada uma revisão de literatura sistematizada nas bases de dados eletrônicas, Pubmed e Medline, limitando-se a busca ao período de 2011 a 2018. Conclusão: Diante das informações apresentadas, o cirurgião-dentista precisa estar apto para obter o diagnóstico correto do trauma dentário. Dessa forma, uma análise criteriosa feita a partir de exames complementares é indispensável para obter êxito no diagnóstico final.


Introduction: In dentistry, occlusion is the relationship of the upper teeth located in the maxilla with the lower teeth located in the mandible when they are in normal and physiological activity, without causing discomforts and pain to the patient during chewing. Conversely, we have a pathological or adaptive alteration that damages the periodontium due to excessive forces resulting in occlusal trauma. Objectives: This paper aims to synthesize scientifically based information that addresses occlusal trauma in order to highlight the importance of knowledge about its etiology, diagnosis and possible treatments for this pathology. Methods: A literature review systematized in the electronic databases, Pubmed and Medline, was limited to the search for the period from 2011 to 2018. Conclusion: Given the information presented, the dental surgeon must be able to obtain the correct diagnosis of dental trauma. Thus, a careful analysis made from complementary tests is indispensable to be successful in the final diagnosis.


Subject(s)
Dental Occlusion , Periodontium
16.
Article in Chinese | WPRIM | ID: wpr-772653

ABSTRACT

Periodontal disease is a common oral disease that can cause irreversible damage of periodontal support tissue. Studies on the relationship between periodontal disease and malignancies have also increased. In this review, the relationship between periodontal disease and gastrointestinal malignancies (e.g., stomach cancer, colorectal cancer, and pancreatic cancer), lung cancer, and breast cancer are discussed. The related mechanisms are summarized in terms of four aspects, namely, immu-nity, inflammation, gene, and microbiota and its products, to provide novel methods for the prevention and early diagnosis of malignancies.


Subject(s)
Humans , Microbiota , Neoplasms , Periodontal Diseases , Periodontium , Research
17.
Article in Chinese | WPRIM | ID: wpr-772649

ABSTRACT

Periodontal tissue, especially the alveolar bone, are closely associated with the progress and efficacy of orthodontic treatment. Prior to and during orthodontic treatment, dentists should fully evaluate the status of periodontal hard tissues to prevent clinical problems. This article aims to discuss bone issues associated with orthodontic treatment, including gingival papilla absence, alveolar bone insufficiency, excessive cortical resistance, and altered passive eruption, etc. The mechanism and prevention methods of these problems are also described.


Subject(s)
Gingiva , Periodontium
18.
Article in Chinese | WPRIM | ID: wpr-772634

ABSTRACT

Periodontitis is a chronic inflammatory disease of periodontal tissues initiated by oral biofilm. Cellular autophagy is an effective weapon against bacterial infection. Recent studies have shown that autophagy not only promotes the removal of bacteria and toxins from infected cells, but also helps to suppress the inflammatory response to maintain the homeostasis of intracellular environment, which is closely related to the development of periodontitis. Here, we reviewed the relationship between autophagy and periodontitis from three aspects: the interactions between autophagy and periodontal pathogen infection, the regulation of autophagy and immune inflammatory responses, and the relationship between autophagy and alveolar bone metabolism. We aim to provide ideas for further study on the mechanisms of autophagy and periodontitis, and ultimately contribute to a better prevention and treatment of periodontitis.


Subject(s)
Autophagy , Bacteria , Biofilms , Humans , Periodontitis , Periodontium
19.
Article in English | WPRIM | ID: wpr-740000

ABSTRACT

Periodontal procedures require adequate anesthesia not only to ensure the patient's comfort but also to enhance the operator's performance and minimize chair time. In the maxilla, anesthesia is often achieved using highly traumatic nerve blocks, apart from multiple local infiltrations through the buccal vestibule. In recent years, anterior middle superior alveolar (AMSA) field block has been claimed to be a less traumatic alternative to several of these conventional injections, and it has many other advantages. This critical review of the existing literature aimed to discuss the rationale, mechanism, effectiveness, extent, and duration of AMSA injections for periodontal surgical and non-surgical procedures in the maxilla. It also focused on future prospects, particularly in relation to computer-controlled local anesthetic delivery systems, which aim to achieve the goal of pain-free anesthesia. A literature search of different databases was performed to retrieve relevant articles related to AMSA injections. After analyzing the existing data, it can be concluded that this anesthetic technique may be used as a predictable method of effective palatal anesthesia with adequate duration for different periodontal procedures. It has additional advantages of being less traumatic, requiring lesser amounts of local anesthetics and vasoconstrictors, as well as achieving good hemostasis. However, its effect on the buccal periodontium appears highly unpredictable.


Subject(s)
Amsacrine , Anesthesia , Anesthetics, Local , Hemostasis , Maxilla , Methods , Nerve Block , Palate , Periodontal Debridement , Periodontium , Vasoconstrictor Agents
20.
Article in English | WPRIM | ID: wpr-766119

ABSTRACT

PURPOSE: Despite the well-known anti-inflammatory effects of vitamin D in periodontal health, its mechanism has not been fully elucidated. In the present study, the effect of vitamin D on strengthening E-cadherin junctions (ECJs) was explored in human gingival keratinocytes (HGKs). ECJs are the major type of intercellular junction within the junctional epithelium, where loose intercellular junctions develop and microbial invasion primarily occurs. METHODS: HOK-16B cells, an immortalized normal human gingival cell line, were used for the study. To mimic the inflammatory environment, cells were treated with tumor necrosis factor-alpha (TNF-α). Matrix metalloproteinases (MMPs) in the culture medium were assessed by an MMP antibody microarray and gelatin zymography. The expression of various molecules was investigated using western blotting. The extent of ECJ development was evaluated by comparing the average relative extent of the ECJs around the periphery of each cell after immunocytochemical E-cadherin staining. Vitamin D receptor (VDR) expression was examined via immunohistochemical analysis. RESULTS: TNF-α downregulated the development of the ECJs of the HGKs. Dissociation of the ECJs by TNF-α was accompanied by the upregulation of MMP-9 production and suppressed by a specific MMP-9 inhibitor, Bay 11-7082. Exogenous MMP-9 decreased the development of ECJs. Vitamin D reduced the production of MMP-9 and attenuated the breakdown of ECJs in the HGKs treated with TNF-α. In addition, vitamin D downregulated TNF-α-induced nuclear factor kappa B (NF-κB) signaling in the HGKs. VDR was expressed in the gingival epithelium, including the junctional epithelium. CONCLUSIONS: These results suggest that vitamin D may avert TNF-α-induced downregulation of the development of ECJs in HGKs by decreasing the production of MMP-9, which was upregulated by TNF-α. Vitamin D may reinforce ECJs by downregulating NF-κB signaling, which is upregulated by TNF-α. Strengthening the epithelial barrier may be a way for vitamin D to protect the periodontium from bacterial invasion.


Subject(s)
Bays , Blotting, Western , Cadherins , Cell Line , Down-Regulation , Epithelial Attachment , Epithelium , Gelatin , Humans , Intercellular Junctions , Keratinocytes , Matrix Metalloproteinase 9 , Matrix Metalloproteinases , NF-kappa B , Periodontium , Receptors, Calcitriol , Tumor Necrosis Factor-alpha , Up-Regulation , Vitamin D , Vitamins
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